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Network neighborhood for query Sequence : NPC1_HUMAN

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NPC1_HUMAN
SwissProt Accessions	O15118, Q9P130	Gene names	NPC1
Domain Architecture
Description	Niemann-Pick C1 protein precursor.
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

NPC1_HUMAN
θ value	0 (rank : 1)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	19	Target Neighborhood Hits	19	Shared Neighborhood Hits	19
SwissProt Accessions	O15118, Q9P130	Gene names	NPC1
Domain Architecture
Description	Niemann-Pick C1 protein precursor.

NPC1_MOUSE
θ value	0 (rank : 2)	NC score	0.998540 (rank : 2)
Query Neighborhood Hits	19	Target Neighborhood Hits	18	Shared Neighborhood Hits	12
SwissProt Accessions	O35604, O35605	Gene names	Npc1
Domain Architecture
Description	Niemann-Pick C1 protein precursor.

NPCL1_HUMAN
θ value	0 (rank : 3)	NC score	0.966225 (rank : 4)
Query Neighborhood Hits	19	Target Neighborhood Hits	25	Shared Neighborhood Hits	9
SwissProt Accessions	Q9UHC9, Q6R3Q4, Q9UHC8	Gene names	NPC1L1
Domain Architecture	No domain graphic available
Description	Niemann-Pick C1-like protein 1 precursor.

NPCL1_MOUSE
θ value	0 (rank : 4)	NC score	0.968164 (rank : 3)
Query Neighborhood Hits	19	Target Neighborhood Hits	21	Shared Neighborhood Hits	9
SwissProt Accessions	Q6T3U4, Q5SVX1	Gene names	Npc1l1
Domain Architecture	No domain graphic available
Description	Niemann-Pick C1-like protein 1 precursor.

PTC1_MOUSE
θ value	5.77852e-31 (rank : 5)	NC score	0.623651 (rank : 6)
Query Neighborhood Hits	19	Target Neighborhood Hits	43	Shared Neighborhood Hits	9
SwissProt Accessions	Q61115	Gene names	Ptch1, Ptch
Domain Architecture
Description	Protein patched homolog 1 (PTC1) (PTC).

PTC1_HUMAN
θ value	2.86786e-30 (rank : 6)	NC score	0.624358 (rank : 5)
Query Neighborhood Hits	19	Target Neighborhood Hits	37	Shared Neighborhood Hits	9
SwissProt Accessions	Q13635, Q13463, Q5VZC0	Gene names	PTCH1, PTCH
Domain Architecture
Description	Protein patched homolog 1 (PTC1) (PTC).

PTC2_HUMAN
θ value	2.96777e-27 (rank : 7)	NC score	0.617970 (rank : 8)
Query Neighborhood Hits	19	Target Neighborhood Hits	63	Shared Neighborhood Hits	9
SwissProt Accessions	Q9Y6C5, O95341, O95856, Q5QP87, Q6UX14	Gene names	PTCH2
Domain Architecture
Description	Protein patched homolog 2 (PTC2).

PTC2_MOUSE
θ value	3.28125e-26 (rank : 8)	NC score	0.622419 (rank : 7)
Query Neighborhood Hits	19	Target Neighborhood Hits	20	Shared Neighborhood Hits	9
SwissProt Accessions	O35595, Q546T0	Gene names	Ptch2
Domain Architecture
Description	Protein patched homolog 2 (PTC2).

SCAP_HUMAN
θ value	3.40345e-15 (rank : 9)	NC score	0.339414 (rank : 9)
Query Neighborhood Hits	19	Target Neighborhood Hits	368	Shared Neighborhood Hits	12
SwissProt Accessions	Q12770, Q8N2E0, Q8WUA1	Gene names	SCAP, KIAA0199
Domain Architecture
Description	Sterol regulatory element-binding protein cleavage-activating protein (SREBP cleavage-activating protein) (SCAP).

HMDH_HUMAN
θ value	1.43324e-05 (rank : 10)	NC score	0.204755 (rank : 10)
Query Neighborhood Hits	19	Target Neighborhood Hits	13	Shared Neighborhood Hits	5
SwissProt Accessions	P04035, Q8N190	Gene names	HMGCR
Domain Architecture
Description	3-hydroxy-3-methylglutaryl-coenzyme A reductase (EC 1.1.1.34) (HMG-CoA reductase).

HMDH_MOUSE
θ value	1.43324e-05 (rank : 11)	NC score	0.203940 (rank : 11)
Query Neighborhood Hits	19	Target Neighborhood Hits	13	Shared Neighborhood Hits	5
SwissProt Accessions	Q01237, Q5U4I2	Gene names	Hmgcr
Domain Architecture	No domain graphic available
Description	3-hydroxy-3-methylglutaryl-coenzyme A reductase (EC 1.1.1.34) (HMG-CoA reductase).

IF38_HUMAN
θ value	2.36792 (rank : 12)	NC score	0.026571 (rank : 12)
Query Neighborhood Hits	19	Target Neighborhood Hits	98	Shared Neighborhood Hits	2
SwissProt Accessions	Q99613, O00215	Gene names	EIF3S8
Domain Architecture
Description	Eukaryotic translation initiation factor 3 subunit 8 (eIF3 p110) (eIF3c).

WDR24_MOUSE
θ value	2.36792 (rank : 13)	NC score	0.019041 (rank : 13)
Query Neighborhood Hits	19	Target Neighborhood Hits	286	Shared Neighborhood Hits	4
SwissProt Accessions	Q8CFJ9	Gene names	Wdr24
Domain Architecture	No domain graphic available
Description	WD repeat protein 24.

KR410_HUMAN
θ value	3.0926 (rank : 14)	NC score	0.014501 (rank : 15)
Query Neighborhood Hits	19	Target Neighborhood Hits	156	Shared Neighborhood Hits	2
SwissProt Accessions	Q9BYQ7	Gene names	KRTAP4-10, KAP4.10, KRTAP4.10
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 4-10 (Keratin-associated protein 4.10) (Ultrahigh sulfur keratin-associated protein 4.10).

GP126_HUMAN
θ value	4.03905 (rank : 15)	NC score	0.015326 (rank : 14)
Query Neighborhood Hits	19	Target Neighborhood Hits	187	Shared Neighborhood Hits	3
SwissProt Accessions	Q86SQ4, Q6MZU7, Q8NC14, Q96JW0	Gene names	GPR126
Domain Architecture	No domain graphic available
Description	Probable G-protein coupled receptor 126 precursor.

ABCA3_HUMAN
θ value	8.99809 (rank : 16)	NC score	0.003053 (rank : 18)
Query Neighborhood Hits	19	Target Neighborhood Hits	107	Shared Neighborhood Hits	2
SwissProt Accessions	Q99758, Q54A95, Q92473	Gene names	ABCA3, ABC3
Domain Architecture
Description	ATP-binding cassette sub-family A member 3 (ATP-binding cassette transporter 3) (ATP-binding cassette 3) (ABC-C transporter).

SCN1A_HUMAN
θ value	8.99809 (rank : 17)	NC score	0.002736 (rank : 19)
Query Neighborhood Hits	19	Target Neighborhood Hits	148	Shared Neighborhood Hits	2
SwissProt Accessions	P35498, Q16172, Q96LA3, Q9C008	Gene names	SCN1A, NAC1, SCN1
Domain Architecture
Description	Sodium channel protein type 1 subunit alpha (Sodium channel protein type I subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.1) (Sodium channel protein, brain I subunit alpha).

TM16E_MOUSE
θ value	8.99809 (rank : 18)	NC score	0.006060 (rank : 17)
Query Neighborhood Hits	19	Target Neighborhood Hits	14	Shared Neighborhood Hits	2
SwissProt Accessions	Q75UR0, Q8CC04	Gene names	Tmem16e, Gdd1
Domain Architecture	No domain graphic available
Description	Transmembrane protein 16E (Gnathodiaphyseal dysplasia 1 protein homolog).

WDR24_HUMAN
θ value	8.99809 (rank : 19)	NC score	0.012928 (rank : 16)
Query Neighborhood Hits	19	Target Neighborhood Hits	247	Shared Neighborhood Hits	3
SwissProt Accessions	Q96S15, Q96GC7, Q9H0B7	Gene names	WDR24
Domain Architecture	No domain graphic available
Description	WD repeat protein 24.

Hits sorted by NC score

NPC1_HUMAN
NC score	0.999962 (rank : 1)	θ value	0 (rank : 1)
Query Neighborhood Hits	19	Target Neighborhood Hits	19	Shared Neighborhood Hits	19
SwissProt Accessions	O15118, Q9P130	Gene names	NPC1
Domain Architecture
Description	Niemann-Pick C1 protein precursor.

NPC1_MOUSE
NC score	0.998540 (rank : 2)	θ value	0 (rank : 2)
Query Neighborhood Hits	19	Target Neighborhood Hits	18	Shared Neighborhood Hits	12
SwissProt Accessions	O35604, O35605	Gene names	Npc1
Domain Architecture
Description	Niemann-Pick C1 protein precursor.

NPCL1_MOUSE
NC score	0.968164 (rank : 3)	θ value	0 (rank : 4)
Query Neighborhood Hits	19	Target Neighborhood Hits	21	Shared Neighborhood Hits	9
SwissProt Accessions	Q6T3U4, Q5SVX1	Gene names	Npc1l1
Domain Architecture	No domain graphic available
Description	Niemann-Pick C1-like protein 1 precursor.

NPCL1_HUMAN
NC score	0.966225 (rank : 4)	θ value	0 (rank : 3)
Query Neighborhood Hits	19	Target Neighborhood Hits	25	Shared Neighborhood Hits	9
SwissProt Accessions	Q9UHC9, Q6R3Q4, Q9UHC8	Gene names	NPC1L1
Domain Architecture	No domain graphic available
Description	Niemann-Pick C1-like protein 1 precursor.

PTC1_HUMAN
NC score	0.624358 (rank : 5)	θ value	2.86786e-30 (rank : 6)
Query Neighborhood Hits	19	Target Neighborhood Hits	37	Shared Neighborhood Hits	9
SwissProt Accessions	Q13635, Q13463, Q5VZC0	Gene names	PTCH1, PTCH
Domain Architecture
Description	Protein patched homolog 1 (PTC1) (PTC).

PTC1_MOUSE
NC score	0.623651 (rank : 6)	θ value	5.77852e-31 (rank : 5)
Query Neighborhood Hits	19	Target Neighborhood Hits	43	Shared Neighborhood Hits	9
SwissProt Accessions	Q61115	Gene names	Ptch1, Ptch
Domain Architecture
Description	Protein patched homolog 1 (PTC1) (PTC).

PTC2_MOUSE
NC score	0.622419 (rank : 7)	θ value	3.28125e-26 (rank : 8)
Query Neighborhood Hits	19	Target Neighborhood Hits	20	Shared Neighborhood Hits	9
SwissProt Accessions	O35595, Q546T0	Gene names	Ptch2
Domain Architecture
Description	Protein patched homolog 2 (PTC2).

PTC2_HUMAN
NC score	0.617970 (rank : 8)	θ value	2.96777e-27 (rank : 7)
Query Neighborhood Hits	19	Target Neighborhood Hits	63	Shared Neighborhood Hits	9
SwissProt Accessions	Q9Y6C5, O95341, O95856, Q5QP87, Q6UX14	Gene names	PTCH2
Domain Architecture
Description	Protein patched homolog 2 (PTC2).

SCAP_HUMAN
NC score	0.339414 (rank : 9)	θ value	3.40345e-15 (rank : 9)
Query Neighborhood Hits	19	Target Neighborhood Hits	368	Shared Neighborhood Hits	12
SwissProt Accessions	Q12770, Q8N2E0, Q8WUA1	Gene names	SCAP, KIAA0199
Domain Architecture
Description	Sterol regulatory element-binding protein cleavage-activating protein (SREBP cleavage-activating protein) (SCAP).

HMDH_HUMAN
NC score	0.204755 (rank : 10)	θ value	1.43324e-05 (rank : 10)
Query Neighborhood Hits	19	Target Neighborhood Hits	13	Shared Neighborhood Hits	5
SwissProt Accessions	P04035, Q8N190	Gene names	HMGCR
Domain Architecture
Description	3-hydroxy-3-methylglutaryl-coenzyme A reductase (EC 1.1.1.34) (HMG-CoA reductase).

HMDH_MOUSE
NC score	0.203940 (rank : 11)	θ value	1.43324e-05 (rank : 11)
Query Neighborhood Hits	19	Target Neighborhood Hits	13	Shared Neighborhood Hits	5
SwissProt Accessions	Q01237, Q5U4I2	Gene names	Hmgcr
Domain Architecture	No domain graphic available
Description	3-hydroxy-3-methylglutaryl-coenzyme A reductase (EC 1.1.1.34) (HMG-CoA reductase).

IF38_HUMAN
NC score	0.026571 (rank : 12)	θ value	2.36792 (rank : 12)
Query Neighborhood Hits	19	Target Neighborhood Hits	98	Shared Neighborhood Hits	2
SwissProt Accessions	Q99613, O00215	Gene names	EIF3S8
Domain Architecture
Description	Eukaryotic translation initiation factor 3 subunit 8 (eIF3 p110) (eIF3c).

WDR24_MOUSE
NC score	0.019041 (rank : 13)	θ value	2.36792 (rank : 13)
Query Neighborhood Hits	19	Target Neighborhood Hits	286	Shared Neighborhood Hits	4
SwissProt Accessions	Q8CFJ9	Gene names	Wdr24
Domain Architecture	No domain graphic available
Description	WD repeat protein 24.

GP126_HUMAN
NC score	0.015326 (rank : 14)	θ value	4.03905 (rank : 15)
Query Neighborhood Hits	19	Target Neighborhood Hits	187	Shared Neighborhood Hits	3
SwissProt Accessions	Q86SQ4, Q6MZU7, Q8NC14, Q96JW0	Gene names	GPR126
Domain Architecture	No domain graphic available
Description	Probable G-protein coupled receptor 126 precursor.

KR410_HUMAN
NC score	0.014501 (rank : 15)	θ value	3.0926 (rank : 14)
Query Neighborhood Hits	19	Target Neighborhood Hits	156	Shared Neighborhood Hits	2
SwissProt Accessions	Q9BYQ7	Gene names	KRTAP4-10, KAP4.10, KRTAP4.10
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 4-10 (Keratin-associated protein 4.10) (Ultrahigh sulfur keratin-associated protein 4.10).

WDR24_HUMAN
NC score	0.012928 (rank : 16)	θ value	8.99809 (rank : 19)
Query Neighborhood Hits	19	Target Neighborhood Hits	247	Shared Neighborhood Hits	3
SwissProt Accessions	Q96S15, Q96GC7, Q9H0B7	Gene names	WDR24
Domain Architecture	No domain graphic available
Description	WD repeat protein 24.

TM16E_MOUSE
NC score	0.006060 (rank : 17)	θ value	8.99809 (rank : 18)
Query Neighborhood Hits	19	Target Neighborhood Hits	14	Shared Neighborhood Hits	2
SwissProt Accessions	Q75UR0, Q8CC04	Gene names	Tmem16e, Gdd1
Domain Architecture	No domain graphic available
Description	Transmembrane protein 16E (Gnathodiaphyseal dysplasia 1 protein homolog).

ABCA3_HUMAN
NC score	0.003053 (rank : 18)	θ value	8.99809 (rank : 16)
Query Neighborhood Hits	19	Target Neighborhood Hits	107	Shared Neighborhood Hits	2
SwissProt Accessions	Q99758, Q54A95, Q92473	Gene names	ABCA3, ABC3
Domain Architecture
Description	ATP-binding cassette sub-family A member 3 (ATP-binding cassette transporter 3) (ATP-binding cassette 3) (ABC-C transporter).

SCN1A_HUMAN
NC score	0.002736 (rank : 19)	θ value	8.99809 (rank : 17)
Query Neighborhood Hits	19	Target Neighborhood Hits	148	Shared Neighborhood Hits	2
SwissProt Accessions	P35498, Q16172, Q96LA3, Q9C008	Gene names	SCN1A, NAC1, SCN1
Domain Architecture
Description	Sodium channel protein type 1 subunit alpha (Sodium channel protein type I subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.1) (Sodium channel protein, brain I subunit alpha).