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Network neighborhood for query Sequence : NPC1_MOUSE

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NPC1_MOUSE
SwissProt Accessions	O35604, O35605	Gene names	Npc1
Domain Architecture
Description	Niemann-Pick C1 protein precursor.
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

NPC1_HUMAN
θ value	0 (rank : 1)	NC score	0.998540 (rank : 2)
Query Neighborhood Hits	18	Target Neighborhood Hits	19	Shared Neighborhood Hits	12
SwissProt Accessions	O15118, Q9P130	Gene names	NPC1
Domain Architecture
Description	Niemann-Pick C1 protein precursor.

NPC1_MOUSE
θ value	0 (rank : 2)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	18	Target Neighborhood Hits	18	Shared Neighborhood Hits	18
SwissProt Accessions	O35604, O35605	Gene names	Npc1
Domain Architecture
Description	Niemann-Pick C1 protein precursor.

NPCL1_HUMAN
θ value	0 (rank : 3)	NC score	0.966119 (rank : 4)
Query Neighborhood Hits	18	Target Neighborhood Hits	25	Shared Neighborhood Hits	9
SwissProt Accessions	Q9UHC9, Q6R3Q4, Q9UHC8	Gene names	NPC1L1
Domain Architecture	No domain graphic available
Description	Niemann-Pick C1-like protein 1 precursor.

NPCL1_MOUSE
θ value	0 (rank : 4)	NC score	0.968062 (rank : 3)
Query Neighborhood Hits	18	Target Neighborhood Hits	21	Shared Neighborhood Hits	9
SwissProt Accessions	Q6T3U4, Q5SVX1	Gene names	Npc1l1
Domain Architecture	No domain graphic available
Description	Niemann-Pick C1-like protein 1 precursor.

PTC1_MOUSE
θ value	1.02001e-27 (rank : 5)	NC score	0.608759 (rank : 6)
Query Neighborhood Hits	18	Target Neighborhood Hits	43	Shared Neighborhood Hits	9
SwissProt Accessions	Q61115	Gene names	Ptch1, Ptch
Domain Architecture
Description	Protein patched homolog 1 (PTC1) (PTC).

PTC1_HUMAN
θ value	2.27234e-27 (rank : 6)	NC score	0.609426 (rank : 5)
Query Neighborhood Hits	18	Target Neighborhood Hits	37	Shared Neighborhood Hits	9
SwissProt Accessions	Q13635, Q13463, Q5VZC0	Gene names	PTCH1, PTCH
Domain Architecture
Description	Protein patched homolog 1 (PTC1) (PTC).

PTC2_HUMAN
θ value	5.23862e-24 (rank : 7)	NC score	0.602906 (rank : 8)
Query Neighborhood Hits	18	Target Neighborhood Hits	63	Shared Neighborhood Hits	9
SwissProt Accessions	Q9Y6C5, O95341, O95856, Q5QP87, Q6UX14	Gene names	PTCH2
Domain Architecture
Description	Protein patched homolog 2 (PTC2).

PTC2_MOUSE
θ value	1.99067e-23 (rank : 8)	NC score	0.607352 (rank : 7)
Query Neighborhood Hits	18	Target Neighborhood Hits	20	Shared Neighborhood Hits	9
SwissProt Accessions	O35595, Q546T0	Gene names	Ptch2
Domain Architecture
Description	Protein patched homolog 2 (PTC2).

SCAP_HUMAN
θ value	6.85773e-16 (rank : 9)	NC score	0.339689 (rank : 9)
Query Neighborhood Hits	18	Target Neighborhood Hits	368	Shared Neighborhood Hits	11
SwissProt Accessions	Q12770, Q8N2E0, Q8WUA1	Gene names	SCAP, KIAA0199
Domain Architecture
Description	Sterol regulatory element-binding protein cleavage-activating protein (SREBP cleavage-activating protein) (SCAP).

HMDH_HUMAN
θ value	4.92598e-06 (rank : 10)	NC score	0.211238 (rank : 10)
Query Neighborhood Hits	18	Target Neighborhood Hits	13	Shared Neighborhood Hits	5
SwissProt Accessions	P04035, Q8N190	Gene names	HMGCR
Domain Architecture
Description	3-hydroxy-3-methylglutaryl-coenzyme A reductase (EC 1.1.1.34) (HMG-CoA reductase).

HMDH_MOUSE
θ value	4.92598e-06 (rank : 11)	NC score	0.210414 (rank : 11)
Query Neighborhood Hits	18	Target Neighborhood Hits	13	Shared Neighborhood Hits	5
SwissProt Accessions	Q01237, Q5U4I2	Gene names	Hmgcr
Domain Architecture	No domain graphic available
Description	3-hydroxy-3-methylglutaryl-coenzyme A reductase (EC 1.1.1.34) (HMG-CoA reductase).

GP126_HUMAN
θ value	0.125558 (rank : 12)	NC score	0.021262 (rank : 15)
Query Neighborhood Hits	18	Target Neighborhood Hits	187	Shared Neighborhood Hits	3
SwissProt Accessions	Q86SQ4, Q6MZU7, Q8NC14, Q96JW0	Gene names	GPR126
Domain Architecture	No domain graphic available
Description	Probable G-protein coupled receptor 126 precursor.

K0690_HUMAN
θ value	1.06291 (rank : 13)	NC score	0.038433 (rank : 12)
Query Neighborhood Hits	18	Target Neighborhood Hits	44	Shared Neighborhood Hits	3
SwissProt Accessions	Q5JTH9, Q5JTH8, Q69YK4, Q96E87, Q9BUH3, Q9Y4C7	Gene names	KIAA0690
Domain Architecture	No domain graphic available
Description	Protein KIAA0690.

K0690_MOUSE
θ value	1.06291 (rank : 14)	NC score	0.038298 (rank : 13)
Query Neighborhood Hits	18	Target Neighborhood Hits	44	Shared Neighborhood Hits	3
SwissProt Accessions	Q6P5B0, Q7TMI5, Q80TU2	Gene names	Kiaa0690
Domain Architecture	No domain graphic available
Description	Protein KIAA0690.

K0174_MOUSE
θ value	3.0926 (rank : 15)	NC score	0.021595 (rank : 14)
Query Neighborhood Hits	18	Target Neighborhood Hits	41	Shared Neighborhood Hits	2
SwissProt Accessions	Q9CX00, Q80U68	Gene names	Kiaa0174
Domain Architecture	No domain graphic available
Description	Protein KIAA0174.

NPAL2_MOUSE
θ value	4.03905 (rank : 16)	NC score	0.013380 (rank : 16)
Query Neighborhood Hits	18	Target Neighborhood Hits	15	Shared Neighborhood Hits	2
SwissProt Accessions	Q91WC7, Q8CC43	Gene names	Npal2, Nipal2
Domain Architecture	No domain graphic available
Description	NIPA-like protein 2.

MDR2_MOUSE
θ value	6.88961 (rank : 17)	NC score	0.003362 (rank : 18)
Query Neighborhood Hits	18	Target Neighborhood Hits	108	Shared Neighborhood Hits	2
SwissProt Accessions	P21440, Q6LCL9	Gene names	Abcb4, Mdr2, Pgy-2, Pgy2
Domain Architecture
Description	Multidrug resistance protein 2 (EC 3.6.3.44) (ATP-binding cassette sub-family B member 4) (P-glycoprotein 2).

NAC2_HUMAN
θ value	8.99809 (rank : 18)	NC score	0.006408 (rank : 17)
Query Neighborhood Hits	18	Target Neighborhood Hits	33	Shared Neighborhood Hits	2
SwissProt Accessions	Q9UPR5	Gene names	SLC8A2, KIAA1087, NCX2
Domain Architecture
Description	Sodium/calcium exchanger 2 precursor (Na(+)/Ca(2+)-exchange protein 2).

Hits sorted by NC score

NPC1_MOUSE
NC score	0.999962 (rank : 1)	θ value	0 (rank : 2)
Query Neighborhood Hits	18	Target Neighborhood Hits	18	Shared Neighborhood Hits	18
SwissProt Accessions	O35604, O35605	Gene names	Npc1
Domain Architecture
Description	Niemann-Pick C1 protein precursor.

NPC1_HUMAN
NC score	0.998540 (rank : 2)	θ value	0 (rank : 1)
Query Neighborhood Hits	18	Target Neighborhood Hits	19	Shared Neighborhood Hits	12
SwissProt Accessions	O15118, Q9P130	Gene names	NPC1
Domain Architecture
Description	Niemann-Pick C1 protein precursor.

NPCL1_MOUSE
NC score	0.968062 (rank : 3)	θ value	0 (rank : 4)
Query Neighborhood Hits	18	Target Neighborhood Hits	21	Shared Neighborhood Hits	9
SwissProt Accessions	Q6T3U4, Q5SVX1	Gene names	Npc1l1
Domain Architecture	No domain graphic available
Description	Niemann-Pick C1-like protein 1 precursor.

NPCL1_HUMAN
NC score	0.966119 (rank : 4)	θ value	0 (rank : 3)
Query Neighborhood Hits	18	Target Neighborhood Hits	25	Shared Neighborhood Hits	9
SwissProt Accessions	Q9UHC9, Q6R3Q4, Q9UHC8	Gene names	NPC1L1
Domain Architecture	No domain graphic available
Description	Niemann-Pick C1-like protein 1 precursor.

PTC1_HUMAN
NC score	0.609426 (rank : 5)	θ value	2.27234e-27 (rank : 6)
Query Neighborhood Hits	18	Target Neighborhood Hits	37	Shared Neighborhood Hits	9
SwissProt Accessions	Q13635, Q13463, Q5VZC0	Gene names	PTCH1, PTCH
Domain Architecture
Description	Protein patched homolog 1 (PTC1) (PTC).

PTC1_MOUSE
NC score	0.608759 (rank : 6)	θ value	1.02001e-27 (rank : 5)
Query Neighborhood Hits	18	Target Neighborhood Hits	43	Shared Neighborhood Hits	9
SwissProt Accessions	Q61115	Gene names	Ptch1, Ptch
Domain Architecture
Description	Protein patched homolog 1 (PTC1) (PTC).

PTC2_MOUSE
NC score	0.607352 (rank : 7)	θ value	1.99067e-23 (rank : 8)
Query Neighborhood Hits	18	Target Neighborhood Hits	20	Shared Neighborhood Hits	9
SwissProt Accessions	O35595, Q546T0	Gene names	Ptch2
Domain Architecture
Description	Protein patched homolog 2 (PTC2).

PTC2_HUMAN
NC score	0.602906 (rank : 8)	θ value	5.23862e-24 (rank : 7)
Query Neighborhood Hits	18	Target Neighborhood Hits	63	Shared Neighborhood Hits	9
SwissProt Accessions	Q9Y6C5, O95341, O95856, Q5QP87, Q6UX14	Gene names	PTCH2
Domain Architecture
Description	Protein patched homolog 2 (PTC2).

SCAP_HUMAN
NC score	0.339689 (rank : 9)	θ value	6.85773e-16 (rank : 9)
Query Neighborhood Hits	18	Target Neighborhood Hits	368	Shared Neighborhood Hits	11
SwissProt Accessions	Q12770, Q8N2E0, Q8WUA1	Gene names	SCAP, KIAA0199
Domain Architecture
Description	Sterol regulatory element-binding protein cleavage-activating protein (SREBP cleavage-activating protein) (SCAP).

HMDH_HUMAN
NC score	0.211238 (rank : 10)	θ value	4.92598e-06 (rank : 10)
Query Neighborhood Hits	18	Target Neighborhood Hits	13	Shared Neighborhood Hits	5
SwissProt Accessions	P04035, Q8N190	Gene names	HMGCR
Domain Architecture
Description	3-hydroxy-3-methylglutaryl-coenzyme A reductase (EC 1.1.1.34) (HMG-CoA reductase).

HMDH_MOUSE
NC score	0.210414 (rank : 11)	θ value	4.92598e-06 (rank : 11)
Query Neighborhood Hits	18	Target Neighborhood Hits	13	Shared Neighborhood Hits	5
SwissProt Accessions	Q01237, Q5U4I2	Gene names	Hmgcr
Domain Architecture	No domain graphic available
Description	3-hydroxy-3-methylglutaryl-coenzyme A reductase (EC 1.1.1.34) (HMG-CoA reductase).

K0690_HUMAN
NC score	0.038433 (rank : 12)	θ value	1.06291 (rank : 13)
Query Neighborhood Hits	18	Target Neighborhood Hits	44	Shared Neighborhood Hits	3
SwissProt Accessions	Q5JTH9, Q5JTH8, Q69YK4, Q96E87, Q9BUH3, Q9Y4C7	Gene names	KIAA0690
Domain Architecture	No domain graphic available
Description	Protein KIAA0690.

K0690_MOUSE
NC score	0.038298 (rank : 13)	θ value	1.06291 (rank : 14)
Query Neighborhood Hits	18	Target Neighborhood Hits	44	Shared Neighborhood Hits	3
SwissProt Accessions	Q6P5B0, Q7TMI5, Q80TU2	Gene names	Kiaa0690
Domain Architecture	No domain graphic available
Description	Protein KIAA0690.

K0174_MOUSE
NC score	0.021595 (rank : 14)	θ value	3.0926 (rank : 15)
Query Neighborhood Hits	18	Target Neighborhood Hits	41	Shared Neighborhood Hits	2
SwissProt Accessions	Q9CX00, Q80U68	Gene names	Kiaa0174
Domain Architecture	No domain graphic available
Description	Protein KIAA0174.

GP126_HUMAN
NC score	0.021262 (rank : 15)	θ value	0.125558 (rank : 12)
Query Neighborhood Hits	18	Target Neighborhood Hits	187	Shared Neighborhood Hits	3
SwissProt Accessions	Q86SQ4, Q6MZU7, Q8NC14, Q96JW0	Gene names	GPR126
Domain Architecture	No domain graphic available
Description	Probable G-protein coupled receptor 126 precursor.

NPAL2_MOUSE
NC score	0.013380 (rank : 16)	θ value	4.03905 (rank : 16)
Query Neighborhood Hits	18	Target Neighborhood Hits	15	Shared Neighborhood Hits	2
SwissProt Accessions	Q91WC7, Q8CC43	Gene names	Npal2, Nipal2
Domain Architecture	No domain graphic available
Description	NIPA-like protein 2.

NAC2_HUMAN
NC score	0.006408 (rank : 17)	θ value	8.99809 (rank : 18)
Query Neighborhood Hits	18	Target Neighborhood Hits	33	Shared Neighborhood Hits	2
SwissProt Accessions	Q9UPR5	Gene names	SLC8A2, KIAA1087, NCX2
Domain Architecture
Description	Sodium/calcium exchanger 2 precursor (Na(+)/Ca(2+)-exchange protein 2).

MDR2_MOUSE
NC score	0.003362 (rank : 18)	θ value	6.88961 (rank : 17)
Query Neighborhood Hits	18	Target Neighborhood Hits	108	Shared Neighborhood Hits	2
SwissProt Accessions	P21440, Q6LCL9	Gene names	Abcb4, Mdr2, Pgy-2, Pgy2
Domain Architecture
Description	Multidrug resistance protein 2 (EC 3.6.3.44) (ATP-binding cassette sub-family B member 4) (P-glycoprotein 2).