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Network neighborhood for query Sequence : DHSA_HUMAN

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DHSA_HUMAN
SwissProt Accessions	P31040, Q16395, Q9UMY5	Gene names	SDHA, SDH2, SDHF
Domain Architecture
Description	Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial precursor (EC 1.3.5.1) (Fp) (Flavoprotein subunit of complex II).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

DHSA_HUMAN
θ value	0 (rank : 1)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	12	Target Neighborhood Hits	12	Shared Neighborhood Hits	12
SwissProt Accessions	P31040, Q16395, Q9UMY5	Gene names	SDHA, SDH2, SDHF
Domain Architecture
Description	Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial precursor (EC 1.3.5.1) (Fp) (Flavoprotein subunit of complex II).

DHSA_MOUSE
θ value	0 (rank : 2)	NC score	0.999470 (rank : 2)
Query Neighborhood Hits	12	Target Neighborhood Hits	12	Shared Neighborhood Hits	11
SwissProt Accessions	Q8K2B3, Q3UH25	Gene names	Sdha
Domain Architecture	No domain graphic available
Description	Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial precursor (EC 1.3.5.1) (Fp) (Flavoprotein subunit of complex II).

CJ033_HUMAN
θ value	0.813845 (rank : 3)	NC score	0.089408 (rank : 3)
Query Neighborhood Hits	12	Target Neighborhood Hits	26	Shared Neighborhood Hits	7
SwissProt Accessions	Q8N2H3, Q5TAA9, Q9BRQ1	Gene names	C10orf33
Domain Architecture	No domain graphic available
Description	Probable oxidoreductase C10orf33 (EC 1.-.-.-).

CJ033_MOUSE
θ value	0.813845 (rank : 4)	NC score	0.088126 (rank : 4)
Query Neighborhood Hits	12	Target Neighborhood Hits	33	Shared Neighborhood Hits	7
SwissProt Accessions	Q3U4I7, Q8CAN2, Q9D630	Gene names
Domain Architecture	No domain graphic available
Description	Probable oxidoreductase C10orf33 homolog (EC 1.-.-.-).

DLDH_MOUSE
θ value	1.38821 (rank : 5)	NC score	0.047267 (rank : 5)
Query Neighborhood Hits	12	Target Neighborhood Hits	35	Shared Neighborhood Hits	6
SwissProt Accessions	O08749	Gene names	Dld
Domain Architecture
Description	Dihydrolipoyl dehydrogenase, mitochondrial precursor (EC 1.8.1.4) (Dihydrolipoamide dehydrogenase).

ITCH_HUMAN
θ value	1.81305 (rank : 6)	NC score	0.022766 (rank : 10)
Query Neighborhood Hits	12	Target Neighborhood Hits	162	Shared Neighborhood Hits	4
SwissProt Accessions	Q96J02, O43584, Q5TEL0, Q96F66, Q9BY75, Q9H451, Q9H4U5	Gene names	ITCH
Domain Architecture
Description	Itchy homolog E3 ubiquitin protein ligase (EC 6.3.2.-) (Itch) (Atrophin-1-interacting protein 4) (AIP4) (NFE2-associated polypeptide 1) (NAPP1).

ACSL6_HUMAN
θ value	2.36792 (rank : 7)	NC score	0.030679 (rank : 7)
Query Neighborhood Hits	12	Target Neighborhood Hits	29	Shared Neighborhood Hits	4
SwissProt Accessions	Q9UKU0, O94924, O95829	Gene names	ACSL6, ACS2, FACL6, KIAA0837, LACS5
Domain Architecture
Description	Long-chain-fatty-acid--CoA ligase 6 (EC 6.2.1.3) (Long-chain acyl-CoA synthetase 6) (LACS 6).

MTRR_HUMAN
θ value	3.0926 (rank : 8)	NC score	0.022814 (rank : 9)
Query Neighborhood Hits	12	Target Neighborhood Hits	18	Shared Neighborhood Hits	2
SwissProt Accessions	Q9UBK8, O60471	Gene names	MTRR
Domain Architecture
Description	Methionine synthase reductase, mitochondrial precursor (EC 1.16.1.8) (MSR).

ITCH_MOUSE
θ value	4.03905 (rank : 9)	NC score	0.019350 (rank : 12)
Query Neighborhood Hits	12	Target Neighborhood Hits	127	Shared Neighborhood Hits	4
SwissProt Accessions	Q8C863, O54971	Gene names	Itch
Domain Architecture
Description	Itchy E3 ubiquitin protein ligase (EC 6.3.2.-).

ACSL6_MOUSE
θ value	5.27518 (rank : 10)	NC score	0.025517 (rank : 8)
Query Neighborhood Hits	12	Target Neighborhood Hits	29	Shared Neighborhood Hits	4
SwissProt Accessions	Q91WC3, Q80ZF1	Gene names	Acsl6, Facl6
Domain Architecture
Description	Long-chain-fatty-acid--CoA ligase 6 (EC 6.2.1.3) (Long-chain acyl-CoA synthetase 6) (LACS 6).

DLDH_HUMAN
θ value	5.27518 (rank : 11)	NC score	0.039332 (rank : 6)
Query Neighborhood Hits	12	Target Neighborhood Hits	34	Shared Neighborhood Hits	6
SwissProt Accessions	P09622, Q14131, Q14167	Gene names	DLD, GCSL, LAD, PHE3
Domain Architecture
Description	Dihydrolipoyl dehydrogenase, mitochondrial precursor (EC 1.8.1.4) (Dihydrolipoamide dehydrogenase) (Glycine cleavage system L protein).

AOFA_MOUSE
θ value	8.99809 (rank : 12)	NC score	0.020541 (rank : 11)
Query Neighborhood Hits	12	Target Neighborhood Hits	37	Shared Neighborhood Hits	5
SwissProt Accessions	Q64133, Q8K0Z8	Gene names	Maoa
Domain Architecture	No domain graphic available
Description	Amine oxidase [flavin-containing] A (EC 1.4.3.4) (Monoamine oxidase type A) (MAO-A).

Hits sorted by NC score

DHSA_HUMAN
NC score	0.999962 (rank : 1)	θ value	0 (rank : 1)
Query Neighborhood Hits	12	Target Neighborhood Hits	12	Shared Neighborhood Hits	12
SwissProt Accessions	P31040, Q16395, Q9UMY5	Gene names	SDHA, SDH2, SDHF
Domain Architecture
Description	Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial precursor (EC 1.3.5.1) (Fp) (Flavoprotein subunit of complex II).

DHSA_MOUSE
NC score	0.999470 (rank : 2)	θ value	0 (rank : 2)
Query Neighborhood Hits	12	Target Neighborhood Hits	12	Shared Neighborhood Hits	11
SwissProt Accessions	Q8K2B3, Q3UH25	Gene names	Sdha
Domain Architecture	No domain graphic available
Description	Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial precursor (EC 1.3.5.1) (Fp) (Flavoprotein subunit of complex II).

CJ033_HUMAN
NC score	0.089408 (rank : 3)	θ value	0.813845 (rank : 3)
Query Neighborhood Hits	12	Target Neighborhood Hits	26	Shared Neighborhood Hits	7
SwissProt Accessions	Q8N2H3, Q5TAA9, Q9BRQ1	Gene names	C10orf33
Domain Architecture	No domain graphic available
Description	Probable oxidoreductase C10orf33 (EC 1.-.-.-).

CJ033_MOUSE
NC score	0.088126 (rank : 4)	θ value	0.813845 (rank : 4)
Query Neighborhood Hits	12	Target Neighborhood Hits	33	Shared Neighborhood Hits	7
SwissProt Accessions	Q3U4I7, Q8CAN2, Q9D630	Gene names
Domain Architecture	No domain graphic available
Description	Probable oxidoreductase C10orf33 homolog (EC 1.-.-.-).

DLDH_MOUSE
NC score	0.047267 (rank : 5)	θ value	1.38821 (rank : 5)
Query Neighborhood Hits	12	Target Neighborhood Hits	35	Shared Neighborhood Hits	6
SwissProt Accessions	O08749	Gene names	Dld
Domain Architecture
Description	Dihydrolipoyl dehydrogenase, mitochondrial precursor (EC 1.8.1.4) (Dihydrolipoamide dehydrogenase).

DLDH_HUMAN
NC score	0.039332 (rank : 6)	θ value	5.27518 (rank : 11)
Query Neighborhood Hits	12	Target Neighborhood Hits	34	Shared Neighborhood Hits	6
SwissProt Accessions	P09622, Q14131, Q14167	Gene names	DLD, GCSL, LAD, PHE3
Domain Architecture
Description	Dihydrolipoyl dehydrogenase, mitochondrial precursor (EC 1.8.1.4) (Dihydrolipoamide dehydrogenase) (Glycine cleavage system L protein).

ACSL6_HUMAN
NC score	0.030679 (rank : 7)	θ value	2.36792 (rank : 7)
Query Neighborhood Hits	12	Target Neighborhood Hits	29	Shared Neighborhood Hits	4
SwissProt Accessions	Q9UKU0, O94924, O95829	Gene names	ACSL6, ACS2, FACL6, KIAA0837, LACS5
Domain Architecture
Description	Long-chain-fatty-acid--CoA ligase 6 (EC 6.2.1.3) (Long-chain acyl-CoA synthetase 6) (LACS 6).

ACSL6_MOUSE
NC score	0.025517 (rank : 8)	θ value	5.27518 (rank : 10)
Query Neighborhood Hits	12	Target Neighborhood Hits	29	Shared Neighborhood Hits	4
SwissProt Accessions	Q91WC3, Q80ZF1	Gene names	Acsl6, Facl6
Domain Architecture
Description	Long-chain-fatty-acid--CoA ligase 6 (EC 6.2.1.3) (Long-chain acyl-CoA synthetase 6) (LACS 6).

MTRR_HUMAN
NC score	0.022814 (rank : 9)	θ value	3.0926 (rank : 8)
Query Neighborhood Hits	12	Target Neighborhood Hits	18	Shared Neighborhood Hits	2
SwissProt Accessions	Q9UBK8, O60471	Gene names	MTRR
Domain Architecture
Description	Methionine synthase reductase, mitochondrial precursor (EC 1.16.1.8) (MSR).

ITCH_HUMAN
NC score	0.022766 (rank : 10)	θ value	1.81305 (rank : 6)
Query Neighborhood Hits	12	Target Neighborhood Hits	162	Shared Neighborhood Hits	4
SwissProt Accessions	Q96J02, O43584, Q5TEL0, Q96F66, Q9BY75, Q9H451, Q9H4U5	Gene names	ITCH
Domain Architecture
Description	Itchy homolog E3 ubiquitin protein ligase (EC 6.3.2.-) (Itch) (Atrophin-1-interacting protein 4) (AIP4) (NFE2-associated polypeptide 1) (NAPP1).

AOFA_MOUSE
NC score	0.020541 (rank : 11)	θ value	8.99809 (rank : 12)
Query Neighborhood Hits	12	Target Neighborhood Hits	37	Shared Neighborhood Hits	5
SwissProt Accessions	Q64133, Q8K0Z8	Gene names	Maoa
Domain Architecture	No domain graphic available
Description	Amine oxidase [flavin-containing] A (EC 1.4.3.4) (Monoamine oxidase type A) (MAO-A).

ITCH_MOUSE
NC score	0.019350 (rank : 12)	θ value	4.03905 (rank : 9)
Query Neighborhood Hits	12	Target Neighborhood Hits	127	Shared Neighborhood Hits	4
SwissProt Accessions	Q8C863, O54971	Gene names	Itch
Domain Architecture
Description	Itchy E3 ubiquitin protein ligase (EC 6.3.2.-).