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Network neighborhood for query Sequence : MTRR_HUMAN

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MTRR_HUMAN
SwissProt Accessions	Q9UBK8, O60471	Gene names	MTRR
Domain Architecture
Description	Methionine synthase reductase, mitochondrial precursor (EC 1.16.1.8) (MSR).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

MTRR_HUMAN
θ value	0 (rank : 1)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	18	Target Neighborhood Hits	18	Shared Neighborhood Hits	18
SwissProt Accessions	Q9UBK8, O60471	Gene names	MTRR
Domain Architecture
Description	Methionine synthase reductase, mitochondrial precursor (EC 1.16.1.8) (MSR).

NCPR_MOUSE
θ value	4.39379e-55 (rank : 2)	NC score	0.911238 (rank : 2)
Query Neighborhood Hits	18	Target Neighborhood Hits	18	Shared Neighborhood Hits	9
SwissProt Accessions	P37040	Gene names	Por
Domain Architecture
Description	NADPH--cytochrome P450 reductase (EC 1.6.2.4) (CPR) (P450R).

NCPR_HUMAN
θ value	2.18062e-54 (rank : 3)	NC score	0.909836 (rank : 3)
Query Neighborhood Hits	18	Target Neighborhood Hits	16	Shared Neighborhood Hits	9
SwissProt Accessions	P16435, Q16455, Q8N181, Q9H3M8	Gene names	POR, CYPOR
Domain Architecture
Description	NADPH--cytochrome P450 reductase (EC 1.6.2.4) (CPR) (P450R).

NOS1_MOUSE
θ value	2.49495e-50 (rank : 4)	NC score	0.814631 (rank : 8)
Query Neighborhood Hits	18	Target Neighborhood Hits	155	Shared Neighborhood Hits	9
SwissProt Accessions	Q9Z0J4, Q64208	Gene names	Nos1
Domain Architecture
Description	Nitric-oxide synthase, brain (EC 1.14.13.39) (NOS type I) (Neuronal NOS) (N-NOS) (nNOS) (Constitutive NOS) (NC-NOS) (bNOS).

NOS1_HUMAN
θ value	2.75849e-49 (rank : 5)	NC score	0.797569 (rank : 9)
Query Neighborhood Hits	18	Target Neighborhood Hits	218	Shared Neighborhood Hits	9
SwissProt Accessions	P29475	Gene names	NOS1
Domain Architecture
Description	Nitric-oxide synthase, brain (EC 1.14.13.39) (NOS type I) (Neuronal NOS) (N-NOS) (nNOS) (Constitutive NOS) (NC-NOS) (bNOS).

NOS2_MOUSE
θ value	1.97686e-47 (rank : 6)	NC score	0.876674 (rank : 4)
Query Neighborhood Hits	18	Target Neighborhood Hits	24	Shared Neighborhood Hits	9
SwissProt Accessions	P29477, O70515, O70516, Q5SXT3, Q6P6A0, Q8R410	Gene names	Nos2, Inosl
Domain Architecture
Description	Nitric oxide synthase, inducible (EC 1.14.13.39) (NOS type II) (Inducible NO synthase) (Inducible NOS) (iNOS) (Macrophage NOS) (MAC- NOS).

NOS2A_HUMAN
θ value	1.41672e-45 (rank : 7)	NC score	0.875527 (rank : 5)
Query Neighborhood Hits	18	Target Neighborhood Hits	21	Shared Neighborhood Hits	9
SwissProt Accessions	P35228, O60757, O94994, Q16263, Q16692, Q4TTS5	Gene names	NOS2A, NOS2
Domain Architecture
Description	Nitric oxide synthase, inducible (EC 1.14.13.39) (NOS type II) (Inducible NO synthase) (Inducible NOS) (iNOS) (Hepatocyte NOS) (HEP- NOS).

NOS3_MOUSE
θ value	3.99248e-40 (rank : 8)	NC score	0.864994 (rank : 7)
Query Neighborhood Hits	18	Target Neighborhood Hits	63	Shared Neighborhood Hits	10
SwissProt Accessions	P70313, O55056	Gene names	Nos3, Ecnos
Domain Architecture
Description	Nitric-oxide synthase, endothelial (EC 1.14.13.39) (EC-NOS) (NOS type III) (NOSIII) (Endothelial NOS) (eNOS) (Constitutive NOS) (cNOS).

NOS3_HUMAN
θ value	1.16164e-39 (rank : 9)	NC score	0.865509 (rank : 6)
Query Neighborhood Hits	18	Target Neighborhood Hits	59	Shared Neighborhood Hits	9
SwissProt Accessions	P29474, Q13662, Q14251, Q14434	Gene names	NOS3
Domain Architecture
Description	Nitric-oxide synthase, endothelial (EC 1.14.13.39) (EC-NOS) (NOS type III) (NOSIII) (Endothelial NOS) (eNOS) (Constitutive NOS) (cNOS).

SETX_HUMAN
θ value	0.47712 (rank : 10)	NC score	0.035183 (rank : 12)
Query Neighborhood Hits	18	Target Neighborhood Hits	368	Shared Neighborhood Hits	3
SwissProt Accessions	Q7Z333, O75120, Q3KQX4, Q68DW5, Q6AZD7, Q7Z3J6, Q8WX33, Q9H9D1, Q9NVP9	Gene names	SETX, ALS4, KIAA0625, SCAR1
Domain Architecture
Description	Probable helicase senataxin (EC 3.6.1.-) (SEN1 homolog).

NEUA_HUMAN
θ value	2.36792 (rank : 11)	NC score	0.038472 (rank : 10)
Query Neighborhood Hits	18	Target Neighborhood Hits	8	Shared Neighborhood Hits	3
SwissProt Accessions	Q8NFW8, Q96AX5, Q9NQZ0	Gene names	CMAS
Domain Architecture	No domain graphic available
Description	N-acylneuraminate cytidylyltransferase (EC 2.7.7.43) (CMP-N- acetylneuraminic acid synthetase) (CMP-NeuNAc synthetase).

DHSA_HUMAN
θ value	3.0926 (rank : 12)	NC score	0.022814 (rank : 13)
Query Neighborhood Hits	18	Target Neighborhood Hits	12	Shared Neighborhood Hits	2
SwissProt Accessions	P31040, Q16395, Q9UMY5	Gene names	SDHA, SDH2, SDHF
Domain Architecture
Description	Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial precursor (EC 1.3.5.1) (Fp) (Flavoprotein subunit of complex II).

NEUA_MOUSE
θ value	3.0926 (rank : 13)	NC score	0.037064 (rank : 11)
Query Neighborhood Hits	18	Target Neighborhood Hits	7	Shared Neighborhood Hits	3
SwissProt Accessions	Q99KK2, O88719, Q8C330, Q8K2G7	Gene names	Cmas
Domain Architecture	No domain graphic available
Description	N-acylneuraminate cytidylyltransferase (EC 2.7.7.43) (CMP-N- acetylneuraminic acid synthetase) (CMP-NeuNAc synthetase).

SMBP2_HUMAN
θ value	4.03905 (rank : 14)	NC score	0.020591 (rank : 14)
Query Neighborhood Hits	18	Target Neighborhood Hits	107	Shared Neighborhood Hits	3
SwissProt Accessions	P38935, Q00443, Q14177	Gene names	IGHMBP2, SMBP2, SMUBP2
Domain Architecture
Description	DNA-binding protein SMUBP-2 (EC 3.6.1.-) (ATP-dependent helicase IGHMBP2) (Immunoglobulin mu-binding protein 2) (SMUBP-2) (Glial factor 1) (GF-1).

IF38_HUMAN
θ value	8.99809 (rank : 15)	NC score	0.014856 (rank : 17)
Query Neighborhood Hits	18	Target Neighborhood Hits	98	Shared Neighborhood Hits	2
SwissProt Accessions	Q99613, O00215	Gene names	EIF3S8
Domain Architecture
Description	Eukaryotic translation initiation factor 3 subunit 8 (eIF3 p110) (eIF3c).

MOB3_HUMAN
θ value	8.99809 (rank : 16)	NC score	0.018180 (rank : 15)
Query Neighborhood Hits	18	Target Neighborhood Hits	16	Shared Neighborhood Hits	3
SwissProt Accessions	Q9Y3A3, Q7Z4Y6, Q9H2P3, Q9H5J1, Q9Y4T8	Gene names	PREI3, MOB3
Domain Architecture	No domain graphic available
Description	Preimplantation protein 3 (Mps one binder kinase activator-like 3) (Mob1 homolog 3) (Mob3) (Class II mMOB1) (2C4D).

MOB3_MOUSE
θ value	8.99809 (rank : 17)	NC score	0.018180 (rank : 16)
Query Neighborhood Hits	18	Target Neighborhood Hits	16	Shared Neighborhood Hits	3
SwissProt Accessions	Q6PEB6, Q3TS21, Q8BSA3, Q9CX28	Gene names	Prei3, Mob3
Domain Architecture	No domain graphic available
Description	Preimplantation protein 3 (Mps one binder kinase activator-like 3) (Mob1 homolog 3) (Mob3) (Class II mMOB1).

TITIN_HUMAN
θ value	8.99809 (rank : 18)	NC score	-0.001025 (rank : 18)
Query Neighborhood Hits	18	Target Neighborhood Hits	2923	Shared Neighborhood Hits	3
SwissProt Accessions	Q8WZ42, Q10465, Q10466, Q15598, Q2XUS3, Q32Q60, Q4U1Z6, Q6NSG0, Q6PDB1, Q6PJP0, Q7KYM2, Q7KYN4, Q7KYN5, Q7LDM3, Q7Z2X3, Q8TCG8, Q8WZ51, Q8WZ52, Q8WZ53, Q8WZB3, Q92761, Q92762, Q9UD97, Q9UP84, Q9Y6L9	Gene names	TTN
Domain Architecture	No domain graphic available
Description	Titin (EC 2.7.11.1) (Connectin) (Rhabdomyosarcoma antigen MU-RMS- 40.14).

Hits sorted by NC score

MTRR_HUMAN
NC score	0.999962 (rank : 1)	θ value	0 (rank : 1)
Query Neighborhood Hits	18	Target Neighborhood Hits	18	Shared Neighborhood Hits	18
SwissProt Accessions	Q9UBK8, O60471	Gene names	MTRR
Domain Architecture
Description	Methionine synthase reductase, mitochondrial precursor (EC 1.16.1.8) (MSR).

NCPR_MOUSE
NC score	0.911238 (rank : 2)	θ value	4.39379e-55 (rank : 2)
Query Neighborhood Hits	18	Target Neighborhood Hits	18	Shared Neighborhood Hits	9
SwissProt Accessions	P37040	Gene names	Por
Domain Architecture
Description	NADPH--cytochrome P450 reductase (EC 1.6.2.4) (CPR) (P450R).

NCPR_HUMAN
NC score	0.909836 (rank : 3)	θ value	2.18062e-54 (rank : 3)
Query Neighborhood Hits	18	Target Neighborhood Hits	16	Shared Neighborhood Hits	9
SwissProt Accessions	P16435, Q16455, Q8N181, Q9H3M8	Gene names	POR, CYPOR
Domain Architecture
Description	NADPH--cytochrome P450 reductase (EC 1.6.2.4) (CPR) (P450R).

NOS2_MOUSE
NC score	0.876674 (rank : 4)	θ value	1.97686e-47 (rank : 6)
Query Neighborhood Hits	18	Target Neighborhood Hits	24	Shared Neighborhood Hits	9
SwissProt Accessions	P29477, O70515, O70516, Q5SXT3, Q6P6A0, Q8R410	Gene names	Nos2, Inosl
Domain Architecture
Description	Nitric oxide synthase, inducible (EC 1.14.13.39) (NOS type II) (Inducible NO synthase) (Inducible NOS) (iNOS) (Macrophage NOS) (MAC- NOS).

NOS2A_HUMAN
NC score	0.875527 (rank : 5)	θ value	1.41672e-45 (rank : 7)
Query Neighborhood Hits	18	Target Neighborhood Hits	21	Shared Neighborhood Hits	9
SwissProt Accessions	P35228, O60757, O94994, Q16263, Q16692, Q4TTS5	Gene names	NOS2A, NOS2
Domain Architecture
Description	Nitric oxide synthase, inducible (EC 1.14.13.39) (NOS type II) (Inducible NO synthase) (Inducible NOS) (iNOS) (Hepatocyte NOS) (HEP- NOS).

NOS3_HUMAN
NC score	0.865509 (rank : 6)	θ value	1.16164e-39 (rank : 9)
Query Neighborhood Hits	18	Target Neighborhood Hits	59	Shared Neighborhood Hits	9
SwissProt Accessions	P29474, Q13662, Q14251, Q14434	Gene names	NOS3
Domain Architecture
Description	Nitric-oxide synthase, endothelial (EC 1.14.13.39) (EC-NOS) (NOS type III) (NOSIII) (Endothelial NOS) (eNOS) (Constitutive NOS) (cNOS).

NOS3_MOUSE
NC score	0.864994 (rank : 7)	θ value	3.99248e-40 (rank : 8)
Query Neighborhood Hits	18	Target Neighborhood Hits	63	Shared Neighborhood Hits	10
SwissProt Accessions	P70313, O55056	Gene names	Nos3, Ecnos
Domain Architecture
Description	Nitric-oxide synthase, endothelial (EC 1.14.13.39) (EC-NOS) (NOS type III) (NOSIII) (Endothelial NOS) (eNOS) (Constitutive NOS) (cNOS).

NOS1_MOUSE
NC score	0.814631 (rank : 8)	θ value	2.49495e-50 (rank : 4)
Query Neighborhood Hits	18	Target Neighborhood Hits	155	Shared Neighborhood Hits	9
SwissProt Accessions	Q9Z0J4, Q64208	Gene names	Nos1
Domain Architecture
Description	Nitric-oxide synthase, brain (EC 1.14.13.39) (NOS type I) (Neuronal NOS) (N-NOS) (nNOS) (Constitutive NOS) (NC-NOS) (bNOS).

NOS1_HUMAN
NC score	0.797569 (rank : 9)	θ value	2.75849e-49 (rank : 5)
Query Neighborhood Hits	18	Target Neighborhood Hits	218	Shared Neighborhood Hits	9
SwissProt Accessions	P29475	Gene names	NOS1
Domain Architecture
Description	Nitric-oxide synthase, brain (EC 1.14.13.39) (NOS type I) (Neuronal NOS) (N-NOS) (nNOS) (Constitutive NOS) (NC-NOS) (bNOS).

NEUA_HUMAN
NC score	0.038472 (rank : 10)	θ value	2.36792 (rank : 11)
Query Neighborhood Hits	18	Target Neighborhood Hits	8	Shared Neighborhood Hits	3
SwissProt Accessions	Q8NFW8, Q96AX5, Q9NQZ0	Gene names	CMAS
Domain Architecture	No domain graphic available
Description	N-acylneuraminate cytidylyltransferase (EC 2.7.7.43) (CMP-N- acetylneuraminic acid synthetase) (CMP-NeuNAc synthetase).

NEUA_MOUSE
NC score	0.037064 (rank : 11)	θ value	3.0926 (rank : 13)
Query Neighborhood Hits	18	Target Neighborhood Hits	7	Shared Neighborhood Hits	3
SwissProt Accessions	Q99KK2, O88719, Q8C330, Q8K2G7	Gene names	Cmas
Domain Architecture	No domain graphic available
Description	N-acylneuraminate cytidylyltransferase (EC 2.7.7.43) (CMP-N- acetylneuraminic acid synthetase) (CMP-NeuNAc synthetase).

SETX_HUMAN
NC score	0.035183 (rank : 12)	θ value	0.47712 (rank : 10)
Query Neighborhood Hits	18	Target Neighborhood Hits	368	Shared Neighborhood Hits	3
SwissProt Accessions	Q7Z333, O75120, Q3KQX4, Q68DW5, Q6AZD7, Q7Z3J6, Q8WX33, Q9H9D1, Q9NVP9	Gene names	SETX, ALS4, KIAA0625, SCAR1
Domain Architecture
Description	Probable helicase senataxin (EC 3.6.1.-) (SEN1 homolog).

DHSA_HUMAN
NC score	0.022814 (rank : 13)	θ value	3.0926 (rank : 12)
Query Neighborhood Hits	18	Target Neighborhood Hits	12	Shared Neighborhood Hits	2
SwissProt Accessions	P31040, Q16395, Q9UMY5	Gene names	SDHA, SDH2, SDHF
Domain Architecture
Description	Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial precursor (EC 1.3.5.1) (Fp) (Flavoprotein subunit of complex II).

SMBP2_HUMAN
NC score	0.020591 (rank : 14)	θ value	4.03905 (rank : 14)
Query Neighborhood Hits	18	Target Neighborhood Hits	107	Shared Neighborhood Hits	3
SwissProt Accessions	P38935, Q00443, Q14177	Gene names	IGHMBP2, SMBP2, SMUBP2
Domain Architecture
Description	DNA-binding protein SMUBP-2 (EC 3.6.1.-) (ATP-dependent helicase IGHMBP2) (Immunoglobulin mu-binding protein 2) (SMUBP-2) (Glial factor 1) (GF-1).

MOB3_HUMAN
NC score	0.018180 (rank : 15)	θ value	8.99809 (rank : 16)
Query Neighborhood Hits	18	Target Neighborhood Hits	16	Shared Neighborhood Hits	3
SwissProt Accessions	Q9Y3A3, Q7Z4Y6, Q9H2P3, Q9H5J1, Q9Y4T8	Gene names	PREI3, MOB3
Domain Architecture	No domain graphic available
Description	Preimplantation protein 3 (Mps one binder kinase activator-like 3) (Mob1 homolog 3) (Mob3) (Class II mMOB1) (2C4D).

MOB3_MOUSE
NC score	0.018180 (rank : 16)	θ value	8.99809 (rank : 17)
Query Neighborhood Hits	18	Target Neighborhood Hits	16	Shared Neighborhood Hits	3
SwissProt Accessions	Q6PEB6, Q3TS21, Q8BSA3, Q9CX28	Gene names	Prei3, Mob3
Domain Architecture	No domain graphic available
Description	Preimplantation protein 3 (Mps one binder kinase activator-like 3) (Mob1 homolog 3) (Mob3) (Class II mMOB1).

IF38_HUMAN
NC score	0.014856 (rank : 17)	θ value	8.99809 (rank : 15)
Query Neighborhood Hits	18	Target Neighborhood Hits	98	Shared Neighborhood Hits	2
SwissProt Accessions	Q99613, O00215	Gene names	EIF3S8
Domain Architecture
Description	Eukaryotic translation initiation factor 3 subunit 8 (eIF3 p110) (eIF3c).

TITIN_HUMAN
NC score	-0.001025 (rank : 18)	θ value	8.99809 (rank : 18)
Query Neighborhood Hits	18	Target Neighborhood Hits	2923	Shared Neighborhood Hits	3
SwissProt Accessions	Q8WZ42, Q10465, Q10466, Q15598, Q2XUS3, Q32Q60, Q4U1Z6, Q6NSG0, Q6PDB1, Q6PJP0, Q7KYM2, Q7KYN4, Q7KYN5, Q7LDM3, Q7Z2X3, Q8TCG8, Q8WZ51, Q8WZ52, Q8WZ53, Q8WZB3, Q92761, Q92762, Q9UD97, Q9UP84, Q9Y6L9	Gene names	TTN
Domain Architecture	No domain graphic available
Description	Titin (EC 2.7.11.1) (Connectin) (Rhabdomyosarcoma antigen MU-RMS- 40.14).