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Network neighborhood for query Sequence : SORC2_MOUSE

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SORC2_MOUSE
SwissProt Accessions	Q9EPR5	Gene names	Sorcs2
Domain Architecture
Description	VPS10 domain-containing receptor SorCS2 precursor.
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

SORC1_HUMAN
θ value	0 (rank : 1)	NC score	0.984879 (rank : 3)
Query Neighborhood Hits	32	Target Neighborhood Hits	28	Shared Neighborhood Hits	11
SwissProt Accessions	Q8WY21, Q59GG7, Q5JVT7, Q5JVT8, Q5VY14, Q86WQ1, Q86WQ2, Q9H1Y1, Q9H1Y2	Gene names	SORCS1, SORCS
Domain Architecture
Description	VPS10 domain-containing receptor SorCS1 precursor (hSorCS).

SORC1_MOUSE
θ value	0 (rank : 2)	NC score	0.984273 (rank : 4)
Query Neighborhood Hits	32	Target Neighborhood Hits	41	Shared Neighborhood Hits	11
SwissProt Accessions	Q9JLC4, Q8VI45, Q922I1, Q9QY21	Gene names	Sorcs1, Sorcs
Domain Architecture
Description	VPS10 domain-containing receptor SorCS1 precursor (mSorCS).

SORC2_HUMAN
θ value	0 (rank : 3)	NC score	0.992881 (rank : 2)
Query Neighborhood Hits	32	Target Neighborhood Hits	66	Shared Neighborhood Hits	14
SwissProt Accessions	Q96PQ0, Q9P2L7	Gene names	SORCS2, KIAA1329
Domain Architecture
Description	VPS10 domain-containing receptor SorCS2 precursor.

SORC2_MOUSE
θ value	0 (rank : 4)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	32	Target Neighborhood Hits	32	Shared Neighborhood Hits	32
SwissProt Accessions	Q9EPR5	Gene names	Sorcs2
Domain Architecture
Description	VPS10 domain-containing receptor SorCS2 precursor.

SORC3_HUMAN
θ value	0 (rank : 5)	NC score	0.981484 (rank : 6)
Query Neighborhood Hits	32	Target Neighborhood Hits	57	Shared Neighborhood Hits	11
SwissProt Accessions	Q9UPU3, Q5VXF9, Q9NQJ2	Gene names	SORCS3, KIAA1059
Domain Architecture
Description	VPS10 domain-containing receptor SorCS3 precursor.

SORC3_MOUSE
θ value	0 (rank : 6)	NC score	0.982754 (rank : 5)
Query Neighborhood Hits	32	Target Neighborhood Hits	45	Shared Neighborhood Hits	13
SwissProt Accessions	Q8VI51, Q9CTR4	Gene names	Sorcs3
Domain Architecture
Description	VPS10 domain-containing receptor SorCS3 precursor.

SORL_HUMAN
θ value	4.22625e-74 (rank : 7)	NC score	0.465491 (rank : 10)
Query Neighborhood Hits	32	Target Neighborhood Hits	440	Shared Neighborhood Hits	13
SwissProt Accessions	Q92673, Q92856	Gene names	SORL1
Domain Architecture
Description	Sortilin-related receptor precursor (Sorting protein-related receptor containing LDLR class A repeats) (SorLA) (SorLA-1) (Low-density lipoprotein receptor relative with 11 ligand-binding repeats) (LDLR relative with 11 ligand-binding repeats) (LR11).

SORL_MOUSE
θ value	5.51964e-74 (rank : 8)	NC score	0.469170 (rank : 9)
Query Neighborhood Hits	32	Target Neighborhood Hits	439	Shared Neighborhood Hits	12
SwissProt Accessions	O88307, O54711, O70581	Gene names	Sorl1
Domain Architecture
Description	Sortilin-related receptor precursor (Sorting protein-related receptor containing LDLR class A repeats) (mSorLA) (SorLA-1) (Low-density lipoprotein receptor relative with 11 ligand-binding repeats) (LDLR relative with 11 ligand-binding repeats) (LR11) (Gp250).

SORT_HUMAN
θ value	2.03627e-60 (rank : 9)	NC score	0.875156 (rank : 8)
Query Neighborhood Hits	32	Target Neighborhood Hits	18	Shared Neighborhood Hits	10
SwissProt Accessions	Q99523, Q8IZ49	Gene names	SORT1
Domain Architecture
Description	Sortilin precursor (Neurotensin receptor 3) (NTR3) (NT3) (Glycoprotein 95) (Gp95) (100 kDa NT receptor).

SORT_MOUSE
θ value	3.47335e-60 (rank : 10)	NC score	0.875667 (rank : 7)
Query Neighborhood Hits	32	Target Neighborhood Hits	13	Shared Neighborhood Hits	10
SwissProt Accessions	Q6PHU5, Q3UHE2, Q8K043, Q9QXW6	Gene names	Sort1
Domain Architecture	No domain graphic available
Description	Sortilin precursor (Neurotensin receptor 3) (NTR3) (mNTR3).

PKD1_HUMAN
θ value	0.279714 (rank : 11)	NC score	0.051282 (rank : 31)
Query Neighborhood Hits	32	Target Neighborhood Hits	387	Shared Neighborhood Hits	7
SwissProt Accessions	P98161, Q15140, Q15141	Gene names	PKD1
Domain Architecture
Description	Polycystin-1 precursor (Autosomal dominant polycystic kidney disease protein 1).

CONA1_MOUSE
θ value	0.365318 (rank : 12)	NC score	0.009954 (rank : 41)
Query Neighborhood Hits	32	Target Neighborhood Hits	254	Shared Neighborhood Hits	3
SwissProt Accessions	Q8K4G2, Q5SUQ0	Gene names	Col23a1
Domain Architecture	No domain graphic available
Description	Collagen alpha-1(XXIII) chain.

ATS16_HUMAN
θ value	0.47712 (rank : 13)	NC score	0.007277 (rank : 45)
Query Neighborhood Hits	32	Target Neighborhood Hits	208	Shared Neighborhood Hits	2
SwissProt Accessions	Q8TE57, Q8IVE2	Gene names	ADAMTS16, KIAA2029
Domain Architecture
Description	ADAMTS-16 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase with thrombospondin motifs 16) (ADAM-TS 16) (ADAM-TS16).

MO4L2_HUMAN
θ value	1.38821 (rank : 14)	NC score	0.021337 (rank : 33)
Query Neighborhood Hits	32	Target Neighborhood Hits	90	Shared Neighborhood Hits	3
SwissProt Accessions	Q15014, Q567V0, Q8J026	Gene names	MORF4L2, KIAA0026, MRGX
Domain Architecture
Description	Mortality factor 4-like protein 2 (MORF-related gene X protein) (Transcription factor-like protein MRGX) (MSL3-2 protein).

MO4L2_MOUSE
θ value	1.81305 (rank : 15)	NC score	0.020631 (rank : 34)
Query Neighborhood Hits	32	Target Neighborhood Hits	86	Shared Neighborhood Hits	3
SwissProt Accessions	Q9R0Q4, Q3UL62, Q6DIB1, Q6ZQK7, Q8C201, Q8C6C2	Gene names	Morf4l2, Kiaa0026, Sid393
Domain Architecture	No domain graphic available
Description	Mortality factor 4-like protein 2 (MORF-related gene X protein) (Transcription factor-like protein MRGX) (Sid 393).

LY9_HUMAN
θ value	2.36792 (rank : 16)	NC score	0.013557 (rank : 36)
Query Neighborhood Hits	32	Target Neighborhood Hits	82	Shared Neighborhood Hits	4
SwissProt Accessions	Q9HBG7, Q14775, Q5VYI3, Q9H4N5, Q9NQ24	Gene names	LY9
Domain Architecture
Description	T-lymphocyte surface antigen Ly-9 precursor (Lymphocyte antigen 9) (Cell-surface molecule Ly-9) (CD229 antigen).

CUL7_HUMAN
θ value	4.03905 (rank : 17)	NC score	0.025437 (rank : 32)
Query Neighborhood Hits	32	Target Neighborhood Hits	41	Shared Neighborhood Hits	4
SwissProt Accessions	Q14999, Q5T654	Gene names	CUL7, KIAA0076
Domain Architecture
Description	Cullin-7 (CUL-7).

CXAR_HUMAN
θ value	4.03905 (rank : 18)	NC score	0.012314 (rank : 39)
Query Neighborhood Hits	32	Target Neighborhood Hits	245	Shared Neighborhood Hits	6
SwissProt Accessions	P78310, O00694, Q8WWT6, Q8WWT7, Q8WWT8, Q9UKV4	Gene names	CXADR, CAR
Domain Architecture
Description	Coxsackievirus and adenovirus receptor precursor (Coxsackievirus B- adenovirus receptor) (hCAR) (CVB3-binding protein) (HCVADR).

CXAR_MOUSE
θ value	4.03905 (rank : 19)	NC score	0.012405 (rank : 38)
Query Neighborhood Hits	32	Target Neighborhood Hits	250	Shared Neighborhood Hits	5
SwissProt Accessions	P97792, O09052, Q3ULD0, Q91W66, Q99KG0, Q9DBJ8	Gene names	Cxadr, Car
Domain Architecture
Description	Coxsackievirus and adenovirus receptor homolog precursor (CAR) (mCAR).

SPEG_MOUSE
θ value	4.03905 (rank : 20)	NC score	-0.000196 (rank : 51)
Query Neighborhood Hits	32	Target Neighborhood Hits	1959	Shared Neighborhood Hits	9
SwissProt Accessions	Q62407, Q3TPH8, Q6P5V1, Q80TF7, Q80ZN0, Q8BZF4, Q9EQJ5	Gene names	Speg, Apeg1, Kiaa1297
Domain Architecture
Description	Striated muscle-specific serine/threonine protein kinase (EC 2.7.11.1) (Aortic preferentially expressed protein 1) (APEG-1).

VLDLR_MOUSE
θ value	4.03905 (rank : 21)	NC score	0.058974 (rank : 13)
Query Neighborhood Hits	32	Target Neighborhood Hits	360	Shared Neighborhood Hits	4
SwissProt Accessions	P98156, Q64022	Gene names	Vldlr
Domain Architecture
Description	Very low-density lipoprotein receptor precursor (VLDL receptor) (VLDL- R).

DIDO1_HUMAN
θ value	5.27518 (rank : 22)	NC score	0.011791 (rank : 40)
Query Neighborhood Hits	32	Target Neighborhood Hits	960	Shared Neighborhood Hits	8
SwissProt Accessions	Q9BTC0, O15043, Q3ZTL7, Q3ZTL8, Q4VXS1, Q4VXS2, Q96D72, Q9BQW0, Q9BW03, Q9H4G6, Q9H4G7, Q9NTU8, Q9NUM8, Q9UFB6	Gene names	DIDO1, C20orf158, DATF1, KIAA0333
Domain Architecture
Description	Death-inducer obliterator 1 (DIO-1) (Death-associated transcription factor 1) (DATF-1) (hDido1).

EDN3_HUMAN
θ value	5.27518 (rank : 23)	NC score	0.012734 (rank : 37)
Query Neighborhood Hits	32	Target Neighborhood Hits	61	Shared Neighborhood Hits	2
SwissProt Accessions	P14138, Q03229	Gene names	EDN3
Domain Architecture
Description	Endothelin-3 precursor (ET-3) (Preproendothelin-3) (PPET3).

ZP1_HUMAN
θ value	5.27518 (rank : 24)	NC score	0.009616 (rank : 42)
Query Neighborhood Hits	32	Target Neighborhood Hits	39	Shared Neighborhood Hits	2
SwissProt Accessions	P60852	Gene names	ZP1
Domain Architecture	No domain graphic available
Description	Zona pellucida sperm-binding protein 1 precursor (Zona pellucida glycoprotein 1) (Zp-1).

CNTN3_MOUSE
θ value	6.88961 (rank : 25)	NC score	0.008037 (rank : 44)
Query Neighborhood Hits	32	Target Neighborhood Hits	447	Shared Neighborhood Hits	7
SwissProt Accessions	Q07409	Gene names	Cntn3, Pang, Pcs
Domain Architecture	No domain graphic available
Description	Contactin-3 precursor (Brain-derived immunoglobulin superfamily protein 1) (BIG-1) (Plasmacytoma-associated neuronal glycoprotein).

TNR16_MOUSE
θ value	6.88961 (rank : 26)	NC score	0.014598 (rank : 35)
Query Neighborhood Hits	32	Target Neighborhood Hits	178	Shared Neighborhood Hits	3
SwissProt Accessions	Q9Z0W1	Gene names	Ngfr, Tnfrsf16
Domain Architecture
Description	Tumor necrosis factor receptor superfamily member 16 precursor (Low- affinity nerve growth factor receptor) (NGF receptor) (Low affinity neurotrophin receptor p75NTR).

EP300_HUMAN
θ value	8.99809 (rank : 27)	NC score	0.003035 (rank : 48)
Query Neighborhood Hits	32	Target Neighborhood Hits	821	Shared Neighborhood Hits	6
SwissProt Accessions	Q09472	Gene names	EP300, P300
Domain Architecture
Description	E1A-associated protein p300 (EC 2.3.1.48).

MAGE1_HUMAN
θ value	8.99809 (rank : 28)	NC score	0.000441 (rank : 50)
Query Neighborhood Hits	32	Target Neighborhood Hits	1389	Shared Neighborhood Hits	6
SwissProt Accessions	Q9HCI5, Q86TG0, Q8TD92, Q9H216	Gene names	MAGEE1, HCA1, KIAA1587
Domain Architecture	No domain graphic available
Description	Melanoma-associated antigen E1 (MAGE-E1 antigen) (Hepatocellular carcinoma-associated protein 1).

MUCDL_HUMAN
θ value	8.99809 (rank : 29)	NC score	0.003241 (rank : 47)
Query Neighborhood Hits	32	Target Neighborhood Hits	777	Shared Neighborhood Hits	6
SwissProt Accessions	Q9HBB8, Q9H746, Q9HAU3, Q9HBB5, Q9HBB6, Q9HBB7, Q9NX86, Q9NXI9	Gene names	MUCDHL
Domain Architecture
Description	Mucin and cadherin-like protein precursor (Mu-protocadherin).

NRP2_HUMAN
θ value	8.99809 (rank : 30)	NC score	0.002241 (rank : 49)
Query Neighborhood Hits	32	Target Neighborhood Hits	120	Shared Neighborhood Hits	2
SwissProt Accessions	O60462, O14820, O14821	Gene names	NRP2, VEGF165R2
Domain Architecture
Description	Neuropilin-2 precursor (Vascular endothelial cell growth factor 165 receptor 2).

PLOD3_MOUSE
θ value	8.99809 (rank : 31)	NC score	0.009143 (rank : 43)
Query Neighborhood Hits	32	Target Neighborhood Hits	11	Shared Neighborhood Hits	3
SwissProt Accessions	Q9R0E1, Q542E0, Q9CYY9	Gene names	Plod3
Domain Architecture
Description	Procollagen-lysine,2-oxoglutarate 5-dioxygenase 3 precursor (EC 1.14.11.4) (Lysyl hydroxylase 3) (LH3).

TBC15_HUMAN
θ value	8.99809 (rank : 32)	NC score	0.005048 (rank : 46)
Query Neighborhood Hits	32	Target Neighborhood Hits	36	Shared Neighborhood Hits	2
SwissProt Accessions	Q8TC07	Gene names	TBC1D15
Domain Architecture	No domain graphic available
Description	TBC1 domain family member 15.

CD320_HUMAN
θ value	θ > 10 (rank : 33)	NC score	0.072077 (rank : 11)
Query Neighborhood Hits	32	Target Neighborhood Hits	103	Shared Neighborhood Hits	3
SwissProt Accessions	Q9NPF0, Q53HF7	Gene names	CD320, 8D6A
Domain Architecture	No domain graphic available
Description	CD320 antigen precursor (8D6 antigen) (FDC-signaling molecule 8D6) (FDC-SM-8D6).

LDLR_HUMAN
θ value	θ > 10 (rank : 34)	NC score	0.053556 (rank : 25)
Query Neighborhood Hits	32	Target Neighborhood Hits	375	Shared Neighborhood Hits	4
SwissProt Accessions	P01130, Q53ZD9	Gene names	LDLR
Domain Architecture
Description	Low-density lipoprotein receptor precursor (LDL receptor).

LDLR_MOUSE
θ value	θ > 10 (rank : 35)	NC score	0.055448 (rank : 19)
Query Neighborhood Hits	32	Target Neighborhood Hits	382	Shared Neighborhood Hits	3
SwissProt Accessions	P35951	Gene names	Ldlr
Domain Architecture
Description	Low-density lipoprotein receptor precursor (LDL receptor).

LRP12_HUMAN
θ value	θ > 10 (rank : 36)	NC score	0.052464 (rank : 28)
Query Neighborhood Hits	32	Target Neighborhood Hits	205	Shared Neighborhood Hits	4
SwissProt Accessions	Q9Y561	Gene names	LRP12, ST7
Domain Architecture
Description	Low-density lipoprotein receptor-related protein 12 precursor (Suppressor of tumorigenicity protein 7).

LRP12_MOUSE
θ value	θ > 10 (rank : 37)	NC score	0.055169 (rank : 22)
Query Neighborhood Hits	32	Target Neighborhood Hits	180	Shared Neighborhood Hits	5
SwissProt Accessions	Q8BUJ9, Q8BWM9	Gene names	Lrp12
Domain Architecture
Description	Low-density lipoprotein receptor-related protein 12 precursor.

LRP1B_HUMAN
θ value	θ > 10 (rank : 38)	NC score	0.052677 (rank : 27)
Query Neighborhood Hits	32	Target Neighborhood Hits	602	Shared Neighborhood Hits	3
SwissProt Accessions	Q9NZR2, Q8WY29, Q8WY30, Q8WY31	Gene names	LRP1B, LRPDIT
Domain Architecture
Description	Low-density lipoprotein receptor-related protein 1B precursor (Low- density lipoprotein receptor-related protein-deleted in tumor) (LRP- DIT).

LRP1B_MOUSE
θ value	θ > 10 (rank : 39)	NC score	0.053365 (rank : 26)
Query Neighborhood Hits	32	Target Neighborhood Hits	606	Shared Neighborhood Hits	4
SwissProt Accessions	Q9JI18, Q8BZD3, Q8BZM7	Gene names	Lrp1b, Lrpdit
Domain Architecture
Description	Low-density lipoprotein receptor-related protein 1B precursor (Low- density lipoprotein receptor-related protein-deleted in tumor) (LRP- DIT).

LRP1_HUMAN
θ value	θ > 10 (rank : 40)	NC score	0.055243 (rank : 21)
Query Neighborhood Hits	32	Target Neighborhood Hits	617	Shared Neighborhood Hits	5
SwissProt Accessions	Q07954, Q2PP12, Q8IVG8	Gene names	LRP1, A2MR
Domain Architecture
Description	Low-density lipoprotein receptor-related protein 1 precursor (LRP) (Alpha-2-macroglobulin receptor) (A2MR) (Apolipoprotein E receptor) (APOER) (CD91 antigen).

LRP2_HUMAN
θ value	θ > 10 (rank : 41)	NC score	0.059969 (rank : 12)
Query Neighborhood Hits	32	Target Neighborhood Hits	573	Shared Neighborhood Hits	3
SwissProt Accessions	P98164, O00711, Q16215	Gene names	LRP2
Domain Architecture
Description	Low-density lipoprotein receptor-related protein 2 precursor (Megalin) (Glycoprotein 330) (gp330).

LRP3_HUMAN
θ value	θ > 10 (rank : 42)	NC score	0.055642 (rank : 18)
Query Neighborhood Hits	32	Target Neighborhood Hits	280	Shared Neighborhood Hits	4
SwissProt Accessions	O75074	Gene names	LRP3
Domain Architecture
Description	Low-density lipoprotein receptor-related protein 3 precursor (hLRp105).

LRP4_HUMAN
θ value	θ > 10 (rank : 43)	NC score	0.052351 (rank : 29)
Query Neighborhood Hits	32	Target Neighborhood Hits	355	Shared Neighborhood Hits	3
SwissProt Accessions	O75096	Gene names	LRP4, KIAA0816, MEGF7
Domain Architecture
Description	Low-density lipoprotein receptor-related protein 4 precursor (Multiple epidermal growth factor-like domains 7).

LRP4_MOUSE
θ value	θ > 10 (rank : 44)	NC score	0.052157 (rank : 30)
Query Neighborhood Hits	32	Target Neighborhood Hits	351	Shared Neighborhood Hits	3
SwissProt Accessions	Q8VI56, Q8BPX5, Q8CBB3, Q8CCP5	Gene names	Lrp4, Kiaa0816
Domain Architecture
Description	Low-density lipoprotein receptor-related protein 4 precursor (LDLR dan).

LRP5_HUMAN
θ value	θ > 10 (rank : 45)	NC score	0.054808 (rank : 23)
Query Neighborhood Hits	32	Target Neighborhood Hits	224	Shared Neighborhood Hits	4
SwissProt Accessions	O75197, Q96TD6, Q9UP66	Gene names	LRP5, LRP7
Domain Architecture
Description	Low-density lipoprotein receptor-related protein 5 precursor.

LRP5_MOUSE
θ value	θ > 10 (rank : 46)	NC score	0.054601 (rank : 24)
Query Neighborhood Hits	32	Target Neighborhood Hits	236	Shared Neighborhood Hits	5
SwissProt Accessions	Q91VN0, O88883, Q9R208	Gene names	Lrp5, Lrp7
Domain Architecture
Description	Low-density lipoprotein receptor-related protein 5 precursor (LRP7) (Lr3).

LRP6_HUMAN
θ value	θ > 10 (rank : 47)	NC score	0.055263 (rank : 20)
Query Neighborhood Hits	32	Target Neighborhood Hits	235	Shared Neighborhood Hits	4
SwissProt Accessions	O75581	Gene names	LRP6
Domain Architecture
Description	Low-density lipoprotein receptor-related protein 6 precursor.

LRP6_MOUSE
θ value	θ > 10 (rank : 48)	NC score	0.055700 (rank : 17)
Query Neighborhood Hits	32	Target Neighborhood Hits	232	Shared Neighborhood Hits	4
SwissProt Accessions	O88572	Gene names	Lrp6
Domain Architecture
Description	Low-density lipoprotein receptor-related protein 6 precursor.

LRP8_HUMAN
θ value	θ > 10 (rank : 49)	NC score	0.055725 (rank : 16)
Query Neighborhood Hits	32	Target Neighborhood Hits	346	Shared Neighborhood Hits	3
SwissProt Accessions	Q14114, O14968, Q86V27, Q99876, Q9BR78	Gene names	LRP8, APOER2
Domain Architecture
Description	Low-density lipoprotein receptor-related protein 8 precursor (Apolipoprotein E receptor 2).

LRP8_MOUSE
θ value	θ > 10 (rank : 50)	NC score	0.056122 (rank : 15)
Query Neighborhood Hits	32	Target Neighborhood Hits	385	Shared Neighborhood Hits	3
SwissProt Accessions	Q924X6, Q8CAK9, Q8CDF5, Q921B6	Gene names	Lrp8, Apoer2
Domain Architecture
Description	Low-density lipoprotein receptor-related protein 8 precursor (Apolipoprotein E receptor 2).

VLDLR_HUMAN
θ value	θ > 10 (rank : 51)	NC score	0.056679 (rank : 14)
Query Neighborhood Hits	32	Target Neighborhood Hits	383	Shared Neighborhood Hits	4
SwissProt Accessions	P98155, Q5VVF6	Gene names	VLDLR
Domain Architecture
Description	Very low-density lipoprotein receptor precursor (VLDL receptor) (VLDL- R).

Hits sorted by NC score

SORC2_MOUSE
NC score	0.999962 (rank : 1)	θ value	0 (rank : 4)
Query Neighborhood Hits	32	Target Neighborhood Hits	32	Shared Neighborhood Hits	32
SwissProt Accessions	Q9EPR5	Gene names	Sorcs2
Domain Architecture
Description	VPS10 domain-containing receptor SorCS2 precursor.

SORC2_HUMAN
NC score	0.992881 (rank : 2)	θ value	0 (rank : 3)
Query Neighborhood Hits	32	Target Neighborhood Hits	66	Shared Neighborhood Hits	14
SwissProt Accessions	Q96PQ0, Q9P2L7	Gene names	SORCS2, KIAA1329
Domain Architecture
Description	VPS10 domain-containing receptor SorCS2 precursor.

SORC1_HUMAN
NC score	0.984879 (rank : 3)	θ value	0 (rank : 1)
Query Neighborhood Hits	32	Target Neighborhood Hits	28	Shared Neighborhood Hits	11
SwissProt Accessions	Q8WY21, Q59GG7, Q5JVT7, Q5JVT8, Q5VY14, Q86WQ1, Q86WQ2, Q9H1Y1, Q9H1Y2	Gene names	SORCS1, SORCS
Domain Architecture
Description	VPS10 domain-containing receptor SorCS1 precursor (hSorCS).

SORC1_MOUSE
NC score	0.984273 (rank : 4)	θ value	0 (rank : 2)
Query Neighborhood Hits	32	Target Neighborhood Hits	41	Shared Neighborhood Hits	11
SwissProt Accessions	Q9JLC4, Q8VI45, Q922I1, Q9QY21	Gene names	Sorcs1, Sorcs
Domain Architecture
Description	VPS10 domain-containing receptor SorCS1 precursor (mSorCS).

SORC3_MOUSE
NC score	0.982754 (rank : 5)	θ value	0 (rank : 6)
Query Neighborhood Hits	32	Target Neighborhood Hits	45	Shared Neighborhood Hits	13
SwissProt Accessions	Q8VI51, Q9CTR4	Gene names	Sorcs3
Domain Architecture
Description	VPS10 domain-containing receptor SorCS3 precursor.

SORC3_HUMAN
NC score	0.981484 (rank : 6)	θ value	0 (rank : 5)
Query Neighborhood Hits	32	Target Neighborhood Hits	57	Shared Neighborhood Hits	11
SwissProt Accessions	Q9UPU3, Q5VXF9, Q9NQJ2	Gene names	SORCS3, KIAA1059
Domain Architecture
Description	VPS10 domain-containing receptor SorCS3 precursor.

SORT_MOUSE
NC score	0.875667 (rank : 7)	θ value	3.47335e-60 (rank : 10)
Query Neighborhood Hits	32	Target Neighborhood Hits	13	Shared Neighborhood Hits	10
SwissProt Accessions	Q6PHU5, Q3UHE2, Q8K043, Q9QXW6	Gene names	Sort1
Domain Architecture	No domain graphic available
Description	Sortilin precursor (Neurotensin receptor 3) (NTR3) (mNTR3).

SORT_HUMAN
NC score	0.875156 (rank : 8)	θ value	2.03627e-60 (rank : 9)
Query Neighborhood Hits	32	Target Neighborhood Hits	18	Shared Neighborhood Hits	10
SwissProt Accessions	Q99523, Q8IZ49	Gene names	SORT1
Domain Architecture
Description	Sortilin precursor (Neurotensin receptor 3) (NTR3) (NT3) (Glycoprotein 95) (Gp95) (100 kDa NT receptor).

SORL_MOUSE
NC score	0.469170 (rank : 9)	θ value	5.51964e-74 (rank : 8)
Query Neighborhood Hits	32	Target Neighborhood Hits	439	Shared Neighborhood Hits	12
SwissProt Accessions	O88307, O54711, O70581	Gene names	Sorl1
Domain Architecture
Description	Sortilin-related receptor precursor (Sorting protein-related receptor containing LDLR class A repeats) (mSorLA) (SorLA-1) (Low-density lipoprotein receptor relative with 11 ligand-binding repeats) (LDLR relative with 11 ligand-binding repeats) (LR11) (Gp250).

SORL_HUMAN
NC score	0.465491 (rank : 10)	θ value	4.22625e-74 (rank : 7)
Query Neighborhood Hits	32	Target Neighborhood Hits	440	Shared Neighborhood Hits	13
SwissProt Accessions	Q92673, Q92856	Gene names	SORL1
Domain Architecture
Description	Sortilin-related receptor precursor (Sorting protein-related receptor containing LDLR class A repeats) (SorLA) (SorLA-1) (Low-density lipoprotein receptor relative with 11 ligand-binding repeats) (LDLR relative with 11 ligand-binding repeats) (LR11).

CD320_HUMAN
NC score	0.072077 (rank : 11)	θ value	θ > 10 (rank : 33)
Query Neighborhood Hits	32	Target Neighborhood Hits	103	Shared Neighborhood Hits	3
SwissProt Accessions	Q9NPF0, Q53HF7	Gene names	CD320, 8D6A
Domain Architecture	No domain graphic available
Description	CD320 antigen precursor (8D6 antigen) (FDC-signaling molecule 8D6) (FDC-SM-8D6).

LRP2_HUMAN
NC score	0.059969 (rank : 12)	θ value	θ > 10 (rank : 41)
Query Neighborhood Hits	32	Target Neighborhood Hits	573	Shared Neighborhood Hits	3
SwissProt Accessions	P98164, O00711, Q16215	Gene names	LRP2
Domain Architecture
Description	Low-density lipoprotein receptor-related protein 2 precursor (Megalin) (Glycoprotein 330) (gp330).

VLDLR_MOUSE
NC score	0.058974 (rank : 13)	θ value	4.03905 (rank : 21)
Query Neighborhood Hits	32	Target Neighborhood Hits	360	Shared Neighborhood Hits	4
SwissProt Accessions	P98156, Q64022	Gene names	Vldlr
Domain Architecture
Description	Very low-density lipoprotein receptor precursor (VLDL receptor) (VLDL- R).

VLDLR_HUMAN
NC score	0.056679 (rank : 14)	θ value	θ > 10 (rank : 51)
Query Neighborhood Hits	32	Target Neighborhood Hits	383	Shared Neighborhood Hits	4
SwissProt Accessions	P98155, Q5VVF6	Gene names	VLDLR
Domain Architecture
Description	Very low-density lipoprotein receptor precursor (VLDL receptor) (VLDL- R).

LRP8_MOUSE
NC score	0.056122 (rank : 15)	θ value	θ > 10 (rank : 50)
Query Neighborhood Hits	32	Target Neighborhood Hits	385	Shared Neighborhood Hits	3
SwissProt Accessions	Q924X6, Q8CAK9, Q8CDF5, Q921B6	Gene names	Lrp8, Apoer2
Domain Architecture
Description	Low-density lipoprotein receptor-related protein 8 precursor (Apolipoprotein E receptor 2).

LRP8_HUMAN
NC score	0.055725 (rank : 16)	θ value	θ > 10 (rank : 49)
Query Neighborhood Hits	32	Target Neighborhood Hits	346	Shared Neighborhood Hits	3
SwissProt Accessions	Q14114, O14968, Q86V27, Q99876, Q9BR78	Gene names	LRP8, APOER2
Domain Architecture
Description	Low-density lipoprotein receptor-related protein 8 precursor (Apolipoprotein E receptor 2).

LRP6_MOUSE
NC score	0.055700 (rank : 17)	θ value	θ > 10 (rank : 48)
Query Neighborhood Hits	32	Target Neighborhood Hits	232	Shared Neighborhood Hits	4
SwissProt Accessions	O88572	Gene names	Lrp6
Domain Architecture
Description	Low-density lipoprotein receptor-related protein 6 precursor.

LRP3_HUMAN
NC score	0.055642 (rank : 18)	θ value	θ > 10 (rank : 42)
Query Neighborhood Hits	32	Target Neighborhood Hits	280	Shared Neighborhood Hits	4
SwissProt Accessions	O75074	Gene names	LRP3
Domain Architecture
Description	Low-density lipoprotein receptor-related protein 3 precursor (hLRp105).

LDLR_MOUSE
NC score	0.055448 (rank : 19)	θ value	θ > 10 (rank : 35)
Query Neighborhood Hits	32	Target Neighborhood Hits	382	Shared Neighborhood Hits	3
SwissProt Accessions	P35951	Gene names	Ldlr
Domain Architecture
Description	Low-density lipoprotein receptor precursor (LDL receptor).

LRP6_HUMAN
NC score	0.055263 (rank : 20)	θ value	θ > 10 (rank : 47)
Query Neighborhood Hits	32	Target Neighborhood Hits	235	Shared Neighborhood Hits	4
SwissProt Accessions	O75581	Gene names	LRP6
Domain Architecture
Description	Low-density lipoprotein receptor-related protein 6 precursor.

LRP1_HUMAN
NC score	0.055243 (rank : 21)	θ value	θ > 10 (rank : 40)
Query Neighborhood Hits	32	Target Neighborhood Hits	617	Shared Neighborhood Hits	5
SwissProt Accessions	Q07954, Q2PP12, Q8IVG8	Gene names	LRP1, A2MR
Domain Architecture
Description	Low-density lipoprotein receptor-related protein 1 precursor (LRP) (Alpha-2-macroglobulin receptor) (A2MR) (Apolipoprotein E receptor) (APOER) (CD91 antigen).

LRP12_MOUSE
NC score	0.055169 (rank : 22)	θ value	θ > 10 (rank : 37)
Query Neighborhood Hits	32	Target Neighborhood Hits	180	Shared Neighborhood Hits	5
SwissProt Accessions	Q8BUJ9, Q8BWM9	Gene names	Lrp12
Domain Architecture
Description	Low-density lipoprotein receptor-related protein 12 precursor.

LRP5_HUMAN
NC score	0.054808 (rank : 23)	θ value	θ > 10 (rank : 45)
Query Neighborhood Hits	32	Target Neighborhood Hits	224	Shared Neighborhood Hits	4
SwissProt Accessions	O75197, Q96TD6, Q9UP66	Gene names	LRP5, LRP7
Domain Architecture
Description	Low-density lipoprotein receptor-related protein 5 precursor.

LRP5_MOUSE
NC score	0.054601 (rank : 24)	θ value	θ > 10 (rank : 46)
Query Neighborhood Hits	32	Target Neighborhood Hits	236	Shared Neighborhood Hits	5
SwissProt Accessions	Q91VN0, O88883, Q9R208	Gene names	Lrp5, Lrp7
Domain Architecture
Description	Low-density lipoprotein receptor-related protein 5 precursor (LRP7) (Lr3).

LDLR_HUMAN
NC score	0.053556 (rank : 25)	θ value	θ > 10 (rank : 34)
Query Neighborhood Hits	32	Target Neighborhood Hits	375	Shared Neighborhood Hits	4
SwissProt Accessions	P01130, Q53ZD9	Gene names	LDLR
Domain Architecture
Description	Low-density lipoprotein receptor precursor (LDL receptor).

LRP1B_MOUSE
NC score	0.053365 (rank : 26)	θ value	θ > 10 (rank : 39)
Query Neighborhood Hits	32	Target Neighborhood Hits	606	Shared Neighborhood Hits	4
SwissProt Accessions	Q9JI18, Q8BZD3, Q8BZM7	Gene names	Lrp1b, Lrpdit
Domain Architecture
Description	Low-density lipoprotein receptor-related protein 1B precursor (Low- density lipoprotein receptor-related protein-deleted in tumor) (LRP- DIT).

LRP1B_HUMAN
NC score	0.052677 (rank : 27)	θ value	θ > 10 (rank : 38)
Query Neighborhood Hits	32	Target Neighborhood Hits	602	Shared Neighborhood Hits	3
SwissProt Accessions	Q9NZR2, Q8WY29, Q8WY30, Q8WY31	Gene names	LRP1B, LRPDIT
Domain Architecture
Description	Low-density lipoprotein receptor-related protein 1B precursor (Low- density lipoprotein receptor-related protein-deleted in tumor) (LRP- DIT).

LRP12_HUMAN
NC score	0.052464 (rank : 28)	θ value	θ > 10 (rank : 36)
Query Neighborhood Hits	32	Target Neighborhood Hits	205	Shared Neighborhood Hits	4
SwissProt Accessions	Q9Y561	Gene names	LRP12, ST7
Domain Architecture
Description	Low-density lipoprotein receptor-related protein 12 precursor (Suppressor of tumorigenicity protein 7).

LRP4_HUMAN
NC score	0.052351 (rank : 29)	θ value	θ > 10 (rank : 43)
Query Neighborhood Hits	32	Target Neighborhood Hits	355	Shared Neighborhood Hits	3
SwissProt Accessions	O75096	Gene names	LRP4, KIAA0816, MEGF7
Domain Architecture
Description	Low-density lipoprotein receptor-related protein 4 precursor (Multiple epidermal growth factor-like domains 7).

LRP4_MOUSE
NC score	0.052157 (rank : 30)	θ value	θ > 10 (rank : 44)
Query Neighborhood Hits	32	Target Neighborhood Hits	351	Shared Neighborhood Hits	3
SwissProt Accessions	Q8VI56, Q8BPX5, Q8CBB3, Q8CCP5	Gene names	Lrp4, Kiaa0816
Domain Architecture
Description	Low-density lipoprotein receptor-related protein 4 precursor (LDLR dan).

PKD1_HUMAN
NC score	0.051282 (rank : 31)	θ value	0.279714 (rank : 11)
Query Neighborhood Hits	32	Target Neighborhood Hits	387	Shared Neighborhood Hits	7
SwissProt Accessions	P98161, Q15140, Q15141	Gene names	PKD1
Domain Architecture
Description	Polycystin-1 precursor (Autosomal dominant polycystic kidney disease protein 1).

CUL7_HUMAN
NC score	0.025437 (rank : 32)	θ value	4.03905 (rank : 17)
Query Neighborhood Hits	32	Target Neighborhood Hits	41	Shared Neighborhood Hits	4
SwissProt Accessions	Q14999, Q5T654	Gene names	CUL7, KIAA0076
Domain Architecture
Description	Cullin-7 (CUL-7).

MO4L2_HUMAN
NC score	0.021337 (rank : 33)	θ value	1.38821 (rank : 14)
Query Neighborhood Hits	32	Target Neighborhood Hits	90	Shared Neighborhood Hits	3
SwissProt Accessions	Q15014, Q567V0, Q8J026	Gene names	MORF4L2, KIAA0026, MRGX
Domain Architecture
Description	Mortality factor 4-like protein 2 (MORF-related gene X protein) (Transcription factor-like protein MRGX) (MSL3-2 protein).

MO4L2_MOUSE
NC score	0.020631 (rank : 34)	θ value	1.81305 (rank : 15)
Query Neighborhood Hits	32	Target Neighborhood Hits	86	Shared Neighborhood Hits	3
SwissProt Accessions	Q9R0Q4, Q3UL62, Q6DIB1, Q6ZQK7, Q8C201, Q8C6C2	Gene names	Morf4l2, Kiaa0026, Sid393
Domain Architecture	No domain graphic available
Description	Mortality factor 4-like protein 2 (MORF-related gene X protein) (Transcription factor-like protein MRGX) (Sid 393).

TNR16_MOUSE
NC score	0.014598 (rank : 35)	θ value	6.88961 (rank : 26)
Query Neighborhood Hits	32	Target Neighborhood Hits	178	Shared Neighborhood Hits	3
SwissProt Accessions	Q9Z0W1	Gene names	Ngfr, Tnfrsf16
Domain Architecture
Description	Tumor necrosis factor receptor superfamily member 16 precursor (Low- affinity nerve growth factor receptor) (NGF receptor) (Low affinity neurotrophin receptor p75NTR).

LY9_HUMAN
NC score	0.013557 (rank : 36)	θ value	2.36792 (rank : 16)
Query Neighborhood Hits	32	Target Neighborhood Hits	82	Shared Neighborhood Hits	4
SwissProt Accessions	Q9HBG7, Q14775, Q5VYI3, Q9H4N5, Q9NQ24	Gene names	LY9
Domain Architecture
Description	T-lymphocyte surface antigen Ly-9 precursor (Lymphocyte antigen 9) (Cell-surface molecule Ly-9) (CD229 antigen).

EDN3_HUMAN
NC score	0.012734 (rank : 37)	θ value	5.27518 (rank : 23)
Query Neighborhood Hits	32	Target Neighborhood Hits	61	Shared Neighborhood Hits	2
SwissProt Accessions	P14138, Q03229	Gene names	EDN3
Domain Architecture
Description	Endothelin-3 precursor (ET-3) (Preproendothelin-3) (PPET3).

CXAR_MOUSE
NC score	0.012405 (rank : 38)	θ value	4.03905 (rank : 19)
Query Neighborhood Hits	32	Target Neighborhood Hits	250	Shared Neighborhood Hits	5
SwissProt Accessions	P97792, O09052, Q3ULD0, Q91W66, Q99KG0, Q9DBJ8	Gene names	Cxadr, Car
Domain Architecture
Description	Coxsackievirus and adenovirus receptor homolog precursor (CAR) (mCAR).

CXAR_HUMAN
NC score	0.012314 (rank : 39)	θ value	4.03905 (rank : 18)
Query Neighborhood Hits	32	Target Neighborhood Hits	245	Shared Neighborhood Hits	6
SwissProt Accessions	P78310, O00694, Q8WWT6, Q8WWT7, Q8WWT8, Q9UKV4	Gene names	CXADR, CAR
Domain Architecture
Description	Coxsackievirus and adenovirus receptor precursor (Coxsackievirus B- adenovirus receptor) (hCAR) (CVB3-binding protein) (HCVADR).

DIDO1_HUMAN
NC score	0.011791 (rank : 40)	θ value	5.27518 (rank : 22)
Query Neighborhood Hits	32	Target Neighborhood Hits	960	Shared Neighborhood Hits	8
SwissProt Accessions	Q9BTC0, O15043, Q3ZTL7, Q3ZTL8, Q4VXS1, Q4VXS2, Q96D72, Q9BQW0, Q9BW03, Q9H4G6, Q9H4G7, Q9NTU8, Q9NUM8, Q9UFB6	Gene names	DIDO1, C20orf158, DATF1, KIAA0333
Domain Architecture
Description	Death-inducer obliterator 1 (DIO-1) (Death-associated transcription factor 1) (DATF-1) (hDido1).

CONA1_MOUSE
NC score	0.009954 (rank : 41)	θ value	0.365318 (rank : 12)
Query Neighborhood Hits	32	Target Neighborhood Hits	254	Shared Neighborhood Hits	3
SwissProt Accessions	Q8K4G2, Q5SUQ0	Gene names	Col23a1
Domain Architecture	No domain graphic available
Description	Collagen alpha-1(XXIII) chain.

ZP1_HUMAN
NC score	0.009616 (rank : 42)	θ value	5.27518 (rank : 24)
Query Neighborhood Hits	32	Target Neighborhood Hits	39	Shared Neighborhood Hits	2
SwissProt Accessions	P60852	Gene names	ZP1
Domain Architecture	No domain graphic available
Description	Zona pellucida sperm-binding protein 1 precursor (Zona pellucida glycoprotein 1) (Zp-1).

PLOD3_MOUSE
NC score	0.009143 (rank : 43)	θ value	8.99809 (rank : 31)
Query Neighborhood Hits	32	Target Neighborhood Hits	11	Shared Neighborhood Hits	3
SwissProt Accessions	Q9R0E1, Q542E0, Q9CYY9	Gene names	Plod3
Domain Architecture
Description	Procollagen-lysine,2-oxoglutarate 5-dioxygenase 3 precursor (EC 1.14.11.4) (Lysyl hydroxylase 3) (LH3).

CNTN3_MOUSE
NC score	0.008037 (rank : 44)	θ value	6.88961 (rank : 25)
Query Neighborhood Hits	32	Target Neighborhood Hits	447	Shared Neighborhood Hits	7
SwissProt Accessions	Q07409	Gene names	Cntn3, Pang, Pcs
Domain Architecture	No domain graphic available
Description	Contactin-3 precursor (Brain-derived immunoglobulin superfamily protein 1) (BIG-1) (Plasmacytoma-associated neuronal glycoprotein).

ATS16_HUMAN
NC score	0.007277 (rank : 45)	θ value	0.47712 (rank : 13)
Query Neighborhood Hits	32	Target Neighborhood Hits	208	Shared Neighborhood Hits	2
SwissProt Accessions	Q8TE57, Q8IVE2	Gene names	ADAMTS16, KIAA2029
Domain Architecture
Description	ADAMTS-16 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase with thrombospondin motifs 16) (ADAM-TS 16) (ADAM-TS16).

TBC15_HUMAN
NC score	0.005048 (rank : 46)	θ value	8.99809 (rank : 32)
Query Neighborhood Hits	32	Target Neighborhood Hits	36	Shared Neighborhood Hits	2
SwissProt Accessions	Q8TC07	Gene names	TBC1D15
Domain Architecture	No domain graphic available
Description	TBC1 domain family member 15.

MUCDL_HUMAN
NC score	0.003241 (rank : 47)	θ value	8.99809 (rank : 29)
Query Neighborhood Hits	32	Target Neighborhood Hits	777	Shared Neighborhood Hits	6
SwissProt Accessions	Q9HBB8, Q9H746, Q9HAU3, Q9HBB5, Q9HBB6, Q9HBB7, Q9NX86, Q9NXI9	Gene names	MUCDHL
Domain Architecture
Description	Mucin and cadherin-like protein precursor (Mu-protocadherin).

EP300_HUMAN
NC score	0.003035 (rank : 48)	θ value	8.99809 (rank : 27)
Query Neighborhood Hits	32	Target Neighborhood Hits	821	Shared Neighborhood Hits	6
SwissProt Accessions	Q09472	Gene names	EP300, P300
Domain Architecture
Description	E1A-associated protein p300 (EC 2.3.1.48).

NRP2_HUMAN
NC score	0.002241 (rank : 49)	θ value	8.99809 (rank : 30)
Query Neighborhood Hits	32	Target Neighborhood Hits	120	Shared Neighborhood Hits	2
SwissProt Accessions	O60462, O14820, O14821	Gene names	NRP2, VEGF165R2
Domain Architecture
Description	Neuropilin-2 precursor (Vascular endothelial cell growth factor 165 receptor 2).

MAGE1_HUMAN
NC score	0.000441 (rank : 50)	θ value	8.99809 (rank : 28)
Query Neighborhood Hits	32	Target Neighborhood Hits	1389	Shared Neighborhood Hits	6
SwissProt Accessions	Q9HCI5, Q86TG0, Q8TD92, Q9H216	Gene names	MAGEE1, HCA1, KIAA1587
Domain Architecture	No domain graphic available
Description	Melanoma-associated antigen E1 (MAGE-E1 antigen) (Hepatocellular carcinoma-associated protein 1).

SPEG_MOUSE
NC score	-0.000196 (rank : 51)	θ value	4.03905 (rank : 20)
Query Neighborhood Hits	32	Target Neighborhood Hits	1959	Shared Neighborhood Hits	9
SwissProt Accessions	Q62407, Q3TPH8, Q6P5V1, Q80TF7, Q80ZN0, Q8BZF4, Q9EQJ5	Gene names	Speg, Apeg1, Kiaa1297
Domain Architecture
Description	Striated muscle-specific serine/threonine protein kinase (EC 2.7.11.1) (Aortic preferentially expressed protein 1) (APEG-1).