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Network neighborhood for query Sequence : SORC1_HUMAN

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SORC1_HUMAN
SwissProt Accessions	Q8WY21, Q59GG7, Q5JVT7, Q5JVT8, Q5VY14, Q86WQ1, Q86WQ2, Q9H1Y1, Q9H1Y2	Gene names	SORCS1, SORCS
Domain Architecture
Description	VPS10 domain-containing receptor SorCS1 precursor (hSorCS).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

SORC1_HUMAN
θ value	0 (rank : 1)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	28	Target Neighborhood Hits	28	Shared Neighborhood Hits	28
SwissProt Accessions	Q8WY21, Q59GG7, Q5JVT7, Q5JVT8, Q5VY14, Q86WQ1, Q86WQ2, Q9H1Y1, Q9H1Y2	Gene names	SORCS1, SORCS
Domain Architecture
Description	VPS10 domain-containing receptor SorCS1 precursor (hSorCS).

SORC1_MOUSE
θ value	0 (rank : 2)	NC score	0.997661 (rank : 2)
Query Neighborhood Hits	28	Target Neighborhood Hits	41	Shared Neighborhood Hits	16
SwissProt Accessions	Q9JLC4, Q8VI45, Q922I1, Q9QY21	Gene names	Sorcs1, Sorcs
Domain Architecture
Description	VPS10 domain-containing receptor SorCS1 precursor (mSorCS).

SORC2_HUMAN
θ value	0 (rank : 3)	NC score	0.980588 (rank : 6)
Query Neighborhood Hits	28	Target Neighborhood Hits	66	Shared Neighborhood Hits	12
SwissProt Accessions	Q96PQ0, Q9P2L7	Gene names	SORCS2, KIAA1329
Domain Architecture
Description	VPS10 domain-containing receptor SorCS2 precursor.

SORC2_MOUSE
θ value	0 (rank : 4)	NC score	0.984879 (rank : 5)
Query Neighborhood Hits	28	Target Neighborhood Hits	32	Shared Neighborhood Hits	11
SwissProt Accessions	Q9EPR5	Gene names	Sorcs2
Domain Architecture
Description	VPS10 domain-containing receptor SorCS2 precursor.

SORC3_HUMAN
θ value	0 (rank : 5)	NC score	0.992303 (rank : 4)
Query Neighborhood Hits	28	Target Neighborhood Hits	57	Shared Neighborhood Hits	12
SwissProt Accessions	Q9UPU3, Q5VXF9, Q9NQJ2	Gene names	SORCS3, KIAA1059
Domain Architecture
Description	VPS10 domain-containing receptor SorCS3 precursor.

SORC3_MOUSE
θ value	0 (rank : 6)	NC score	0.993316 (rank : 3)
Query Neighborhood Hits	28	Target Neighborhood Hits	45	Shared Neighborhood Hits	12
SwissProt Accessions	Q8VI51, Q9CTR4	Gene names	Sorcs3
Domain Architecture
Description	VPS10 domain-containing receptor SorCS3 precursor.

SORL_HUMAN
θ value	3.24342e-66 (rank : 7)	NC score	0.457116 (rank : 10)
Query Neighborhood Hits	28	Target Neighborhood Hits	440	Shared Neighborhood Hits	13
SwissProt Accessions	Q92673, Q92856	Gene names	SORL1
Domain Architecture
Description	Sortilin-related receptor precursor (Sorting protein-related receptor containing LDLR class A repeats) (SorLA) (SorLA-1) (Low-density lipoprotein receptor relative with 11 ligand-binding repeats) (LDLR relative with 11 ligand-binding repeats) (LR11).

SORL_MOUSE
θ value	7.2256e-66 (rank : 8)	NC score	0.460659 (rank : 9)
Query Neighborhood Hits	28	Target Neighborhood Hits	439	Shared Neighborhood Hits	13
SwissProt Accessions	O88307, O54711, O70581	Gene names	Sorl1
Domain Architecture
Description	Sortilin-related receptor precursor (Sorting protein-related receptor containing LDLR class A repeats) (mSorLA) (SorLA-1) (Low-density lipoprotein receptor relative with 11 ligand-binding repeats) (LDLR relative with 11 ligand-binding repeats) (LR11) (Gp250).

SORT_MOUSE
θ value	7.24236e-58 (rank : 9)	NC score	0.864482 (rank : 7)
Query Neighborhood Hits	28	Target Neighborhood Hits	13	Shared Neighborhood Hits	10
SwissProt Accessions	Q6PHU5, Q3UHE2, Q8K043, Q9QXW6	Gene names	Sort1
Domain Architecture	No domain graphic available
Description	Sortilin precursor (Neurotensin receptor 3) (NTR3) (mNTR3).

SORT_HUMAN
θ value	1.61343e-57 (rank : 10)	NC score	0.863684 (rank : 8)
Query Neighborhood Hits	28	Target Neighborhood Hits	18	Shared Neighborhood Hits	10
SwissProt Accessions	Q99523, Q8IZ49	Gene names	SORT1
Domain Architecture
Description	Sortilin precursor (Neurotensin receptor 3) (NTR3) (NT3) (Glycoprotein 95) (Gp95) (100 kDa NT receptor).

FOXH1_HUMAN
θ value	0.163984 (rank : 11)	NC score	0.021178 (rank : 27)
Query Neighborhood Hits	28	Target Neighborhood Hits	258	Shared Neighborhood Hits	4
SwissProt Accessions	O75593	Gene names	FOXH1, FAST1, FAST2
Domain Architecture
Description	Forkhead box protein H1 (Forkhead activin signal transducer 1) (Fast- 1) (hFAST-1) (Forkhead activin signal transducer 2) (Fast-2).

PKD1_HUMAN
θ value	0.47712 (rank : 12)	NC score	0.049880 (rank : 23)
Query Neighborhood Hits	28	Target Neighborhood Hits	387	Shared Neighborhood Hits	7
SwissProt Accessions	P98161, Q15140, Q15141	Gene names	PKD1
Domain Architecture
Description	Polycystin-1 precursor (Autosomal dominant polycystic kidney disease protein 1).

TIP60_HUMAN
θ value	0.47712 (rank : 13)	NC score	0.022768 (rank : 25)
Query Neighborhood Hits	28	Target Neighborhood Hits	90	Shared Neighborhood Hits	3
SwissProt Accessions	Q92993, O95624, Q13430, Q6GSE8, Q9BWK7	Gene names	HTATIP, TIP60
Domain Architecture
Description	Histone acetyltransferase HTATIP (EC 2.3.1.48) (EC 2.3.1.-) (60 kDa Tat interactive protein) (Tip60) (HIV-1 Tat interactive protein) (cPLA(2)-interacting protein).

USH2A_HUMAN
θ value	0.47712 (rank : 14)	NC score	0.026195 (rank : 24)
Query Neighborhood Hits	28	Target Neighborhood Hits	600	Shared Neighborhood Hits	9
SwissProt Accessions	O75445, Q5VVM9, Q6S362, Q9NS27	Gene names	USH2A
Domain Architecture	No domain graphic available
Description	Usherin precursor (Usher syndrome type-2A protein) (Usher syndrome type IIa protein).

WHRN_MOUSE
θ value	0.62314 (rank : 15)	NC score	0.011978 (rank : 29)
Query Neighborhood Hits	28	Target Neighborhood Hits	412	Shared Neighborhood Hits	4
SwissProt Accessions	Q80VW5, Q80TC2, Q80VW4	Gene names	Whrn, Kiaa1526
Domain Architecture	No domain graphic available
Description	Whirlin.

TIP60_MOUSE
θ value	0.813845 (rank : 16)	NC score	0.021648 (rank : 26)
Query Neighborhood Hits	28	Target Neighborhood Hits	95	Shared Neighborhood Hits	3
SwissProt Accessions	Q8CHK4, Q8CGZ3, Q8CGZ4, Q8VIH0	Gene names	Htatip, Tip60
Domain Architecture
Description	Histone acetyltransferase HTATIP (EC 2.3.1.48) (EC 2.3.1.-) (60 kDa Tat interactive protein) (Tip60).

CAD15_HUMAN
θ value	1.06291 (rank : 17)	NC score	0.005197 (rank : 36)
Query Neighborhood Hits	28	Target Neighborhood Hits	173	Shared Neighborhood Hits	3
SwissProt Accessions	P55291	Gene names	CDH15, CDH14, CDH3
Domain Architecture
Description	Cadherin-15 precursor (Muscle-cadherin) (M-cadherin) (Cadherin-14).

CEAM5_HUMAN
θ value	3.0926 (rank : 18)	NC score	0.006176 (rank : 34)
Query Neighborhood Hits	28	Target Neighborhood Hits	343	Shared Neighborhood Hits	3
SwissProt Accessions	P06731	Gene names	CEACAM5, CEA
Domain Architecture
Description	Carcinoembryonic antigen-related cell adhesion molecule 5 precursor (Carcinoembryonic antigen) (CEA) (Meconium antigen 100) (CD66e antigen).

SRBS1_HUMAN
θ value	3.0926 (rank : 19)	NC score	0.008501 (rank : 32)
Query Neighborhood Hits	28	Target Neighborhood Hits	396	Shared Neighborhood Hits	3
SwissProt Accessions	Q9BX66, Q7LBE5, Q8IVK0, Q8IVQ4, Q96KF3, Q96KF4, Q9BX64, Q9BX65, Q9P2Q0, Q9UFT2, Q9UHN7, Q9Y338	Gene names	SORBS1, KIAA1296, SH3D5
Domain Architecture	No domain graphic available
Description	Sorbin and SH3 domain-containing protein 1 (Ponsin) (c-Cbl-associated protein) (CAP) (SH3 domain protein 5) (SH3P12).

GLI4_HUMAN
θ value	4.03905 (rank : 20)	NC score	-0.001636 (rank : 39)
Query Neighborhood Hits	28	Target Neighborhood Hits	735	Shared Neighborhood Hits	2
SwissProt Accessions	P10075, Q96CK9	Gene names	GLI4, HKR4
Domain Architecture
Description	Zinc finger protein GLI4 (Krueppel-related zinc finger protein 4) (Protein HKR4).

PAPPA_HUMAN
θ value	4.03905 (rank : 21)	NC score	0.019588 (rank : 28)
Query Neighborhood Hits	28	Target Neighborhood Hits	161	Shared Neighborhood Hits	5
SwissProt Accessions	Q13219, Q08371, Q68G52, Q9UDK7	Gene names	PAPPA
Domain Architecture
Description	Pappalysin-1 precursor (EC 3.4.24.79) (Pregnancy-associated plasma protein-A) (PAPP-A) (Insulin-like growth factor-dependent IGF-binding protein 4 protease) (IGF-dependent IGFBP-4 protease) (IGFBP-4ase).

ADAM8_HUMAN
θ value	6.88961 (rank : 22)	NC score	0.005531 (rank : 35)
Query Neighborhood Hits	28	Target Neighborhood Hits	327	Shared Neighborhood Hits	5
SwissProt Accessions	P78325	Gene names	ADAM8, MS2
Domain Architecture
Description	ADAM 8 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase domain 8) (Cell surface antigen MS2) (CD156a antigen) (CD156).

LRP12_MOUSE
θ value	6.88961 (rank : 23)	NC score	0.052784 (rank : 14)
Query Neighborhood Hits	28	Target Neighborhood Hits	180	Shared Neighborhood Hits	5
SwissProt Accessions	Q8BUJ9, Q8BWM9	Gene names	Lrp12
Domain Architecture
Description	Low-density lipoprotein receptor-related protein 12 precursor.

SYN1_MOUSE
θ value	6.88961 (rank : 24)	NC score	0.005141 (rank : 37)
Query Neighborhood Hits	28	Target Neighborhood Hits	363	Shared Neighborhood Hits	3
SwissProt Accessions	O88935, Q62279, Q8QZT8	Gene names	Syn1, Syn-1
Domain Architecture
Description	Synapsin-1 (Synapsin I).

TROAP_HUMAN
θ value	6.88961 (rank : 25)	NC score	0.010284 (rank : 30)
Query Neighborhood Hits	28	Target Neighborhood Hits	258	Shared Neighborhood Hits	2
SwissProt Accessions	Q12815	Gene names	TROAP
Domain Architecture	No domain graphic available
Description	Trophinin-associated protein (Tastin) (Trophinin-assisting protein).

HTRA3_HUMAN
θ value	8.99809 (rank : 26)	NC score	0.009326 (rank : 31)
Query Neighborhood Hits	28	Target Neighborhood Hits	152	Shared Neighborhood Hits	4
SwissProt Accessions	P83110, Q7Z7A2	Gene names	HTRA3, PRSP
Domain Architecture
Description	Probable serine protease HTRA3 precursor (EC 3.4.21.-) (High- temperature requirement factor A3) (Pregnancy-related serine protease).

STAC_HUMAN
θ value	8.99809 (rank : 27)	NC score	0.006596 (rank : 33)
Query Neighborhood Hits	28	Target Neighborhood Hits	276	Shared Neighborhood Hits	4
SwissProt Accessions	Q99469	Gene names	STAC
Domain Architecture
Description	SH3 and cysteine-rich domain-containing protein (SRC homology 3 and cysteine-rich domain protein).

TBX18_MOUSE
θ value	8.99809 (rank : 28)	NC score	0.002888 (rank : 38)
Query Neighborhood Hits	28	Target Neighborhood Hits	58	Shared Neighborhood Hits	4
SwissProt Accessions	Q9EPZ6	Gene names	Tbx18
Domain Architecture
Description	T-box transcription factor TBX18 (T-box protein 18).

CD320_HUMAN
θ value	θ > 10 (rank : 29)	NC score	0.065926 (rank : 11)
Query Neighborhood Hits	28	Target Neighborhood Hits	103	Shared Neighborhood Hits	3
SwissProt Accessions	Q9NPF0, Q53HF7	Gene names	CD320, 8D6A
Domain Architecture	No domain graphic available
Description	CD320 antigen precursor (8D6 antigen) (FDC-signaling molecule 8D6) (FDC-SM-8D6).

LDLR_MOUSE
θ value	θ > 10 (rank : 30)	NC score	0.050291 (rank : 22)
Query Neighborhood Hits	28	Target Neighborhood Hits	382	Shared Neighborhood Hits	4
SwissProt Accessions	P35951	Gene names	Ldlr
Domain Architecture
Description	Low-density lipoprotein receptor precursor (LDL receptor).

LRP1_HUMAN
θ value	θ > 10 (rank : 31)	NC score	0.051041 (rank : 18)
Query Neighborhood Hits	28	Target Neighborhood Hits	617	Shared Neighborhood Hits	7
SwissProt Accessions	Q07954, Q2PP12, Q8IVG8	Gene names	LRP1, A2MR
Domain Architecture
Description	Low-density lipoprotein receptor-related protein 1 precursor (LRP) (Alpha-2-macroglobulin receptor) (A2MR) (Apolipoprotein E receptor) (APOER) (CD91 antigen).

LRP2_HUMAN
θ value	θ > 10 (rank : 32)	NC score	0.055151 (rank : 12)
Query Neighborhood Hits	28	Target Neighborhood Hits	573	Shared Neighborhood Hits	6
SwissProt Accessions	P98164, O00711, Q16215	Gene names	LRP2
Domain Architecture
Description	Low-density lipoprotein receptor-related protein 2 precursor (Megalin) (Glycoprotein 330) (gp330).

LRP3_HUMAN
θ value	θ > 10 (rank : 33)	NC score	0.052209 (rank : 15)
Query Neighborhood Hits	28	Target Neighborhood Hits	280	Shared Neighborhood Hits	4
SwissProt Accessions	O75074	Gene names	LRP3
Domain Architecture
Description	Low-density lipoprotein receptor-related protein 3 precursor (hLRp105).

LRP6_HUMAN
θ value	θ > 10 (rank : 34)	NC score	0.050393 (rank : 21)
Query Neighborhood Hits	28	Target Neighborhood Hits	235	Shared Neighborhood Hits	4
SwissProt Accessions	O75581	Gene names	LRP6
Domain Architecture
Description	Low-density lipoprotein receptor-related protein 6 precursor.

LRP6_MOUSE
θ value	θ > 10 (rank : 35)	NC score	0.050669 (rank : 19)
Query Neighborhood Hits	28	Target Neighborhood Hits	232	Shared Neighborhood Hits	3
SwissProt Accessions	O88572	Gene names	Lrp6
Domain Architecture
Description	Low-density lipoprotein receptor-related protein 6 precursor.

LRP8_HUMAN
θ value	θ > 10 (rank : 36)	NC score	0.050462 (rank : 20)
Query Neighborhood Hits	28	Target Neighborhood Hits	346	Shared Neighborhood Hits	4
SwissProt Accessions	Q14114, O14968, Q86V27, Q99876, Q9BR78	Gene names	LRP8, APOER2
Domain Architecture
Description	Low-density lipoprotein receptor-related protein 8 precursor (Apolipoprotein E receptor 2).

LRP8_MOUSE
θ value	θ > 10 (rank : 37)	NC score	0.051324 (rank : 16)
Query Neighborhood Hits	28	Target Neighborhood Hits	385	Shared Neighborhood Hits	5
SwissProt Accessions	Q924X6, Q8CAK9, Q8CDF5, Q921B6	Gene names	Lrp8, Apoer2
Domain Architecture
Description	Low-density lipoprotein receptor-related protein 8 precursor (Apolipoprotein E receptor 2).

VLDLR_HUMAN
θ value	θ > 10 (rank : 38)	NC score	0.051122 (rank : 17)
Query Neighborhood Hits	28	Target Neighborhood Hits	383	Shared Neighborhood Hits	4
SwissProt Accessions	P98155, Q5VVF6	Gene names	VLDLR
Domain Architecture
Description	Very low-density lipoprotein receptor precursor (VLDL receptor) (VLDL- R).

VLDLR_MOUSE
θ value	θ > 10 (rank : 39)	NC score	0.053027 (rank : 13)
Query Neighborhood Hits	28	Target Neighborhood Hits	360	Shared Neighborhood Hits	5
SwissProt Accessions	P98156, Q64022	Gene names	Vldlr
Domain Architecture
Description	Very low-density lipoprotein receptor precursor (VLDL receptor) (VLDL- R).

Hits sorted by NC score

SORC1_HUMAN
NC score	0.999962 (rank : 1)	θ value	0 (rank : 1)
Query Neighborhood Hits	28	Target Neighborhood Hits	28	Shared Neighborhood Hits	28
SwissProt Accessions	Q8WY21, Q59GG7, Q5JVT7, Q5JVT8, Q5VY14, Q86WQ1, Q86WQ2, Q9H1Y1, Q9H1Y2	Gene names	SORCS1, SORCS
Domain Architecture
Description	VPS10 domain-containing receptor SorCS1 precursor (hSorCS).

SORC1_MOUSE
NC score	0.997661 (rank : 2)	θ value	0 (rank : 2)
Query Neighborhood Hits	28	Target Neighborhood Hits	41	Shared Neighborhood Hits	16
SwissProt Accessions	Q9JLC4, Q8VI45, Q922I1, Q9QY21	Gene names	Sorcs1, Sorcs
Domain Architecture
Description	VPS10 domain-containing receptor SorCS1 precursor (mSorCS).

SORC3_MOUSE
NC score	0.993316 (rank : 3)	θ value	0 (rank : 6)
Query Neighborhood Hits	28	Target Neighborhood Hits	45	Shared Neighborhood Hits	12
SwissProt Accessions	Q8VI51, Q9CTR4	Gene names	Sorcs3
Domain Architecture
Description	VPS10 domain-containing receptor SorCS3 precursor.

SORC3_HUMAN
NC score	0.992303 (rank : 4)	θ value	0 (rank : 5)
Query Neighborhood Hits	28	Target Neighborhood Hits	57	Shared Neighborhood Hits	12
SwissProt Accessions	Q9UPU3, Q5VXF9, Q9NQJ2	Gene names	SORCS3, KIAA1059
Domain Architecture
Description	VPS10 domain-containing receptor SorCS3 precursor.

SORC2_MOUSE
NC score	0.984879 (rank : 5)	θ value	0 (rank : 4)
Query Neighborhood Hits	28	Target Neighborhood Hits	32	Shared Neighborhood Hits	11
SwissProt Accessions	Q9EPR5	Gene names	Sorcs2
Domain Architecture
Description	VPS10 domain-containing receptor SorCS2 precursor.

SORC2_HUMAN
NC score	0.980588 (rank : 6)	θ value	0 (rank : 3)
Query Neighborhood Hits	28	Target Neighborhood Hits	66	Shared Neighborhood Hits	12
SwissProt Accessions	Q96PQ0, Q9P2L7	Gene names	SORCS2, KIAA1329
Domain Architecture
Description	VPS10 domain-containing receptor SorCS2 precursor.

SORT_MOUSE
NC score	0.864482 (rank : 7)	θ value	7.24236e-58 (rank : 9)
Query Neighborhood Hits	28	Target Neighborhood Hits	13	Shared Neighborhood Hits	10
SwissProt Accessions	Q6PHU5, Q3UHE2, Q8K043, Q9QXW6	Gene names	Sort1
Domain Architecture	No domain graphic available
Description	Sortilin precursor (Neurotensin receptor 3) (NTR3) (mNTR3).

SORT_HUMAN
NC score	0.863684 (rank : 8)	θ value	1.61343e-57 (rank : 10)
Query Neighborhood Hits	28	Target Neighborhood Hits	18	Shared Neighborhood Hits	10
SwissProt Accessions	Q99523, Q8IZ49	Gene names	SORT1
Domain Architecture
Description	Sortilin precursor (Neurotensin receptor 3) (NTR3) (NT3) (Glycoprotein 95) (Gp95) (100 kDa NT receptor).

SORL_MOUSE
NC score	0.460659 (rank : 9)	θ value	7.2256e-66 (rank : 8)
Query Neighborhood Hits	28	Target Neighborhood Hits	439	Shared Neighborhood Hits	13
SwissProt Accessions	O88307, O54711, O70581	Gene names	Sorl1
Domain Architecture
Description	Sortilin-related receptor precursor (Sorting protein-related receptor containing LDLR class A repeats) (mSorLA) (SorLA-1) (Low-density lipoprotein receptor relative with 11 ligand-binding repeats) (LDLR relative with 11 ligand-binding repeats) (LR11) (Gp250).

SORL_HUMAN
NC score	0.457116 (rank : 10)	θ value	3.24342e-66 (rank : 7)
Query Neighborhood Hits	28	Target Neighborhood Hits	440	Shared Neighborhood Hits	13
SwissProt Accessions	Q92673, Q92856	Gene names	SORL1
Domain Architecture
Description	Sortilin-related receptor precursor (Sorting protein-related receptor containing LDLR class A repeats) (SorLA) (SorLA-1) (Low-density lipoprotein receptor relative with 11 ligand-binding repeats) (LDLR relative with 11 ligand-binding repeats) (LR11).

CD320_HUMAN
NC score	0.065926 (rank : 11)	θ value	θ > 10 (rank : 29)
Query Neighborhood Hits	28	Target Neighborhood Hits	103	Shared Neighborhood Hits	3
SwissProt Accessions	Q9NPF0, Q53HF7	Gene names	CD320, 8D6A
Domain Architecture	No domain graphic available
Description	CD320 antigen precursor (8D6 antigen) (FDC-signaling molecule 8D6) (FDC-SM-8D6).

LRP2_HUMAN
NC score	0.055151 (rank : 12)	θ value	θ > 10 (rank : 32)
Query Neighborhood Hits	28	Target Neighborhood Hits	573	Shared Neighborhood Hits	6
SwissProt Accessions	P98164, O00711, Q16215	Gene names	LRP2
Domain Architecture
Description	Low-density lipoprotein receptor-related protein 2 precursor (Megalin) (Glycoprotein 330) (gp330).

VLDLR_MOUSE
NC score	0.053027 (rank : 13)	θ value	θ > 10 (rank : 39)
Query Neighborhood Hits	28	Target Neighborhood Hits	360	Shared Neighborhood Hits	5
SwissProt Accessions	P98156, Q64022	Gene names	Vldlr
Domain Architecture
Description	Very low-density lipoprotein receptor precursor (VLDL receptor) (VLDL- R).

LRP12_MOUSE
NC score	0.052784 (rank : 14)	θ value	6.88961 (rank : 23)
Query Neighborhood Hits	28	Target Neighborhood Hits	180	Shared Neighborhood Hits	5
SwissProt Accessions	Q8BUJ9, Q8BWM9	Gene names	Lrp12
Domain Architecture
Description	Low-density lipoprotein receptor-related protein 12 precursor.

LRP3_HUMAN
NC score	0.052209 (rank : 15)	θ value	θ > 10 (rank : 33)
Query Neighborhood Hits	28	Target Neighborhood Hits	280	Shared Neighborhood Hits	4
SwissProt Accessions	O75074	Gene names	LRP3
Domain Architecture
Description	Low-density lipoprotein receptor-related protein 3 precursor (hLRp105).

LRP8_MOUSE
NC score	0.051324 (rank : 16)	θ value	θ > 10 (rank : 37)
Query Neighborhood Hits	28	Target Neighborhood Hits	385	Shared Neighborhood Hits	5
SwissProt Accessions	Q924X6, Q8CAK9, Q8CDF5, Q921B6	Gene names	Lrp8, Apoer2
Domain Architecture
Description	Low-density lipoprotein receptor-related protein 8 precursor (Apolipoprotein E receptor 2).

VLDLR_HUMAN
NC score	0.051122 (rank : 17)	θ value	θ > 10 (rank : 38)
Query Neighborhood Hits	28	Target Neighborhood Hits	383	Shared Neighborhood Hits	4
SwissProt Accessions	P98155, Q5VVF6	Gene names	VLDLR
Domain Architecture
Description	Very low-density lipoprotein receptor precursor (VLDL receptor) (VLDL- R).

LRP1_HUMAN
NC score	0.051041 (rank : 18)	θ value	θ > 10 (rank : 31)
Query Neighborhood Hits	28	Target Neighborhood Hits	617	Shared Neighborhood Hits	7
SwissProt Accessions	Q07954, Q2PP12, Q8IVG8	Gene names	LRP1, A2MR
Domain Architecture
Description	Low-density lipoprotein receptor-related protein 1 precursor (LRP) (Alpha-2-macroglobulin receptor) (A2MR) (Apolipoprotein E receptor) (APOER) (CD91 antigen).

LRP6_MOUSE
NC score	0.050669 (rank : 19)	θ value	θ > 10 (rank : 35)
Query Neighborhood Hits	28	Target Neighborhood Hits	232	Shared Neighborhood Hits	3
SwissProt Accessions	O88572	Gene names	Lrp6
Domain Architecture
Description	Low-density lipoprotein receptor-related protein 6 precursor.

LRP8_HUMAN
NC score	0.050462 (rank : 20)	θ value	θ > 10 (rank : 36)
Query Neighborhood Hits	28	Target Neighborhood Hits	346	Shared Neighborhood Hits	4
SwissProt Accessions	Q14114, O14968, Q86V27, Q99876, Q9BR78	Gene names	LRP8, APOER2
Domain Architecture
Description	Low-density lipoprotein receptor-related protein 8 precursor (Apolipoprotein E receptor 2).

LRP6_HUMAN
NC score	0.050393 (rank : 21)	θ value	θ > 10 (rank : 34)
Query Neighborhood Hits	28	Target Neighborhood Hits	235	Shared Neighborhood Hits	4
SwissProt Accessions	O75581	Gene names	LRP6
Domain Architecture
Description	Low-density lipoprotein receptor-related protein 6 precursor.

LDLR_MOUSE
NC score	0.050291 (rank : 22)	θ value	θ > 10 (rank : 30)
Query Neighborhood Hits	28	Target Neighborhood Hits	382	Shared Neighborhood Hits	4
SwissProt Accessions	P35951	Gene names	Ldlr
Domain Architecture
Description	Low-density lipoprotein receptor precursor (LDL receptor).

PKD1_HUMAN
NC score	0.049880 (rank : 23)	θ value	0.47712 (rank : 12)
Query Neighborhood Hits	28	Target Neighborhood Hits	387	Shared Neighborhood Hits	7
SwissProt Accessions	P98161, Q15140, Q15141	Gene names	PKD1
Domain Architecture
Description	Polycystin-1 precursor (Autosomal dominant polycystic kidney disease protein 1).

USH2A_HUMAN
NC score	0.026195 (rank : 24)	θ value	0.47712 (rank : 14)
Query Neighborhood Hits	28	Target Neighborhood Hits	600	Shared Neighborhood Hits	9
SwissProt Accessions	O75445, Q5VVM9, Q6S362, Q9NS27	Gene names	USH2A
Domain Architecture	No domain graphic available
Description	Usherin precursor (Usher syndrome type-2A protein) (Usher syndrome type IIa protein).

TIP60_HUMAN
NC score	0.022768 (rank : 25)	θ value	0.47712 (rank : 13)
Query Neighborhood Hits	28	Target Neighborhood Hits	90	Shared Neighborhood Hits	3
SwissProt Accessions	Q92993, O95624, Q13430, Q6GSE8, Q9BWK7	Gene names	HTATIP, TIP60
Domain Architecture
Description	Histone acetyltransferase HTATIP (EC 2.3.1.48) (EC 2.3.1.-) (60 kDa Tat interactive protein) (Tip60) (HIV-1 Tat interactive protein) (cPLA(2)-interacting protein).

TIP60_MOUSE
NC score	0.021648 (rank : 26)	θ value	0.813845 (rank : 16)
Query Neighborhood Hits	28	Target Neighborhood Hits	95	Shared Neighborhood Hits	3
SwissProt Accessions	Q8CHK4, Q8CGZ3, Q8CGZ4, Q8VIH0	Gene names	Htatip, Tip60
Domain Architecture
Description	Histone acetyltransferase HTATIP (EC 2.3.1.48) (EC 2.3.1.-) (60 kDa Tat interactive protein) (Tip60).

FOXH1_HUMAN
NC score	0.021178 (rank : 27)	θ value	0.163984 (rank : 11)
Query Neighborhood Hits	28	Target Neighborhood Hits	258	Shared Neighborhood Hits	4
SwissProt Accessions	O75593	Gene names	FOXH1, FAST1, FAST2
Domain Architecture
Description	Forkhead box protein H1 (Forkhead activin signal transducer 1) (Fast- 1) (hFAST-1) (Forkhead activin signal transducer 2) (Fast-2).

PAPPA_HUMAN
NC score	0.019588 (rank : 28)	θ value	4.03905 (rank : 21)
Query Neighborhood Hits	28	Target Neighborhood Hits	161	Shared Neighborhood Hits	5
SwissProt Accessions	Q13219, Q08371, Q68G52, Q9UDK7	Gene names	PAPPA
Domain Architecture
Description	Pappalysin-1 precursor (EC 3.4.24.79) (Pregnancy-associated plasma protein-A) (PAPP-A) (Insulin-like growth factor-dependent IGF-binding protein 4 protease) (IGF-dependent IGFBP-4 protease) (IGFBP-4ase).

WHRN_MOUSE
NC score	0.011978 (rank : 29)	θ value	0.62314 (rank : 15)
Query Neighborhood Hits	28	Target Neighborhood Hits	412	Shared Neighborhood Hits	4
SwissProt Accessions	Q80VW5, Q80TC2, Q80VW4	Gene names	Whrn, Kiaa1526
Domain Architecture	No domain graphic available
Description	Whirlin.

TROAP_HUMAN
NC score	0.010284 (rank : 30)	θ value	6.88961 (rank : 25)
Query Neighborhood Hits	28	Target Neighborhood Hits	258	Shared Neighborhood Hits	2
SwissProt Accessions	Q12815	Gene names	TROAP
Domain Architecture	No domain graphic available
Description	Trophinin-associated protein (Tastin) (Trophinin-assisting protein).

HTRA3_HUMAN
NC score	0.009326 (rank : 31)	θ value	8.99809 (rank : 26)
Query Neighborhood Hits	28	Target Neighborhood Hits	152	Shared Neighborhood Hits	4
SwissProt Accessions	P83110, Q7Z7A2	Gene names	HTRA3, PRSP
Domain Architecture
Description	Probable serine protease HTRA3 precursor (EC 3.4.21.-) (High- temperature requirement factor A3) (Pregnancy-related serine protease).

SRBS1_HUMAN
NC score	0.008501 (rank : 32)	θ value	3.0926 (rank : 19)
Query Neighborhood Hits	28	Target Neighborhood Hits	396	Shared Neighborhood Hits	3
SwissProt Accessions	Q9BX66, Q7LBE5, Q8IVK0, Q8IVQ4, Q96KF3, Q96KF4, Q9BX64, Q9BX65, Q9P2Q0, Q9UFT2, Q9UHN7, Q9Y338	Gene names	SORBS1, KIAA1296, SH3D5
Domain Architecture	No domain graphic available
Description	Sorbin and SH3 domain-containing protein 1 (Ponsin) (c-Cbl-associated protein) (CAP) (SH3 domain protein 5) (SH3P12).

STAC_HUMAN
NC score	0.006596 (rank : 33)	θ value	8.99809 (rank : 27)
Query Neighborhood Hits	28	Target Neighborhood Hits	276	Shared Neighborhood Hits	4
SwissProt Accessions	Q99469	Gene names	STAC
Domain Architecture
Description	SH3 and cysteine-rich domain-containing protein (SRC homology 3 and cysteine-rich domain protein).

CEAM5_HUMAN
NC score	0.006176 (rank : 34)	θ value	3.0926 (rank : 18)
Query Neighborhood Hits	28	Target Neighborhood Hits	343	Shared Neighborhood Hits	3
SwissProt Accessions	P06731	Gene names	CEACAM5, CEA
Domain Architecture
Description	Carcinoembryonic antigen-related cell adhesion molecule 5 precursor (Carcinoembryonic antigen) (CEA) (Meconium antigen 100) (CD66e antigen).

ADAM8_HUMAN
NC score	0.005531 (rank : 35)	θ value	6.88961 (rank : 22)
Query Neighborhood Hits	28	Target Neighborhood Hits	327	Shared Neighborhood Hits	5
SwissProt Accessions	P78325	Gene names	ADAM8, MS2
Domain Architecture
Description	ADAM 8 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase domain 8) (Cell surface antigen MS2) (CD156a antigen) (CD156).

CAD15_HUMAN
NC score	0.005197 (rank : 36)	θ value	1.06291 (rank : 17)
Query Neighborhood Hits	28	Target Neighborhood Hits	173	Shared Neighborhood Hits	3
SwissProt Accessions	P55291	Gene names	CDH15, CDH14, CDH3
Domain Architecture
Description	Cadherin-15 precursor (Muscle-cadherin) (M-cadherin) (Cadherin-14).

SYN1_MOUSE
NC score	0.005141 (rank : 37)	θ value	6.88961 (rank : 24)
Query Neighborhood Hits	28	Target Neighborhood Hits	363	Shared Neighborhood Hits	3
SwissProt Accessions	O88935, Q62279, Q8QZT8	Gene names	Syn1, Syn-1
Domain Architecture
Description	Synapsin-1 (Synapsin I).

TBX18_MOUSE
NC score	0.002888 (rank : 38)	θ value	8.99809 (rank : 28)
Query Neighborhood Hits	28	Target Neighborhood Hits	58	Shared Neighborhood Hits	4
SwissProt Accessions	Q9EPZ6	Gene names	Tbx18
Domain Architecture
Description	T-box transcription factor TBX18 (T-box protein 18).

GLI4_HUMAN
NC score	-0.001636 (rank : 39)	θ value	4.03905 (rank : 20)
Query Neighborhood Hits	28	Target Neighborhood Hits	735	Shared Neighborhood Hits	2
SwissProt Accessions	P10075, Q96CK9	Gene names	GLI4, HKR4
Domain Architecture
Description	Zinc finger protein GLI4 (Krueppel-related zinc finger protein 4) (Protein HKR4).