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Network neighborhood for query Sequence : MIA_HUMAN

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MIA_HUMAN
SwissProt Accessions	Q16674	Gene names	MIA
Domain Architecture
Description	Melanoma-derived growth regulatory protein precursor (Melanoma inhibitory activity).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

MIA_HUMAN
θ value	1.22964e-73 (rank : 1)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	19	Target Neighborhood Hits	19	Shared Neighborhood Hits	19
SwissProt Accessions	Q16674	Gene names	MIA
Domain Architecture
Description	Melanoma-derived growth regulatory protein precursor (Melanoma inhibitory activity).

MIA_MOUSE
θ value	9.45883e-58 (rank : 2)	NC score	0.994854 (rank : 2)
Query Neighborhood Hits	19	Target Neighborhood Hits	17	Shared Neighborhood Hits	15
SwissProt Accessions	Q61865, O09086, P97495	Gene names	Mia, Cdrap, Mia1
Domain Architecture
Description	Melanoma-derived growth regulatory protein precursor (Melanoma inhibitory activity) (Cartilage-derived retinoic acid-sensitive protein) (CD-RAP).

OTOR_MOUSE
θ value	4.43474e-23 (rank : 3)	NC score	0.891046 (rank : 3)
Query Neighborhood Hits	19	Target Neighborhood Hits	15	Shared Neighborhood Hits	14
SwissProt Accessions	Q9JIE3	Gene names	Otor, Mial
Domain Architecture
Description	Otoraplin precursor (Melanoma inhibitory activity-like protein).

OTOR_HUMAN
θ value	3.17815e-21 (rank : 4)	NC score	0.871820 (rank : 4)
Query Neighborhood Hits	19	Target Neighborhood Hits	12	Shared Neighborhood Hits	12
SwissProt Accessions	Q9NRC9	Gene names	OTOR, FDP, MIAL
Domain Architecture
Description	Otoraplin precursor (Fibrocyte-derived protein) (Melanoma inhibitory activity-like protein).

MIA2_HUMAN
θ value	1.133e-10 (rank : 5)	NC score	0.584551 (rank : 5)
Query Neighborhood Hits	19	Target Neighborhood Hits	28	Shared Neighborhood Hits	6
SwissProt Accessions	Q96PC5, Q9H6C1	Gene names	MIA2
Domain Architecture	No domain graphic available
Description	Melanoma inhibitory activity protein 2 precursor.

MIA2_MOUSE
θ value	5.62301e-10 (rank : 6)	NC score	0.564074 (rank : 6)
Query Neighborhood Hits	19	Target Neighborhood Hits	109	Shared Neighborhood Hits	11
SwissProt Accessions	Q91ZV0	Gene names	Mia2
Domain Architecture	No domain graphic available
Description	Melanoma inhibitory activity protein 2 precursor.

VAV3_HUMAN
θ value	9.29e-05 (rank : 7)	NC score	0.207343 (rank : 7)
Query Neighborhood Hits	19	Target Neighborhood Hits	398	Shared Neighborhood Hits	17
SwissProt Accessions	Q9UKW4, O95230, Q9Y5X8	Gene names	VAV3
Domain Architecture
Description	Protein vav-3.

VAV3_MOUSE
θ value	0.00020696 (rank : 8)	NC score	0.204633 (rank : 8)
Query Neighborhood Hits	19	Target Neighborhood Hits	404	Shared Neighborhood Hits	17
SwissProt Accessions	Q9R0C8, Q7TS85	Gene names	Vav3
Domain Architecture
Description	Protein vav-3.

VAV2_HUMAN
θ value	0.00298849 (rank : 9)	NC score	0.190929 (rank : 10)
Query Neighborhood Hits	19	Target Neighborhood Hits	453	Shared Neighborhood Hits	17
SwissProt Accessions	P52735	Gene names	VAV2
Domain Architecture
Description	Protein vav-2.

VAV2_MOUSE
θ value	0.00298849 (rank : 10)	NC score	0.192257 (rank : 9)
Query Neighborhood Hits	19	Target Neighborhood Hits	456	Shared Neighborhood Hits	17
SwissProt Accessions	Q60992	Gene names	Vav2
Domain Architecture
Description	Protein vav-2.

AHI1_HUMAN
θ value	0.0563607 (rank : 11)	NC score	0.115380 (rank : 13)
Query Neighborhood Hits	19	Target Neighborhood Hits	537	Shared Neighborhood Hits	17
SwissProt Accessions	Q8N157, Q504T3, Q5TCP9, Q6P098, Q6PIT6, Q8NDX0, Q9H0H2	Gene names	AHI1
Domain Architecture	No domain graphic available
Description	Jouberin (Abelson helper integration site 1 protein homolog) (AHI-1).

AHI1_MOUSE
θ value	0.0563607 (rank : 12)	NC score	0.105405 (rank : 14)
Query Neighborhood Hits	19	Target Neighborhood Hits	496	Shared Neighborhood Hits	16
SwissProt Accessions	Q8K3E5, Q7TNV2, Q9CVY1	Gene names	Ahi1
Domain Architecture	No domain graphic available
Description	Jouberin (Abelson helper integration site 1 protein) (AHI-1).

VAV_MOUSE
θ value	0.21417 (rank : 13)	NC score	0.175658 (rank : 11)
Query Neighborhood Hits	19	Target Neighborhood Hits	430	Shared Neighborhood Hits	17
SwissProt Accessions	P27870, Q8BTV7	Gene names	Vav1, Vav
Domain Architecture
Description	Proto-oncogene vav (p95vav).

VAV_HUMAN
θ value	0.62314 (rank : 14)	NC score	0.169819 (rank : 12)
Query Neighborhood Hits	19	Target Neighborhood Hits	452	Shared Neighborhood Hits	17
SwissProt Accessions	P15498, Q15860	Gene names	VAV1, VAV
Domain Architecture
Description	Proto-oncogene vav.

SHAN1_HUMAN
θ value	1.06291 (rank : 15)	NC score	0.041887 (rank : 49)
Query Neighborhood Hits	19	Target Neighborhood Hits	1041	Shared Neighborhood Hits	13
SwissProt Accessions	Q9Y566, Q9NYW9	Gene names	SHANK1
Domain Architecture
Description	SH3 and multiple ankyrin repeat domains protein 1 (Shank1) (Somatostatin receptor-interacting protein) (SSTR-interacting protein) (SSTRIP).

ITSN2_HUMAN
θ value	5.27518 (rank : 16)	NC score	0.045846 (rank : 48)
Query Neighborhood Hits	19	Target Neighborhood Hits	1173	Shared Neighborhood Hits	16
SwissProt Accessions	Q9NZM3, O95062, Q15812, Q9HAK4, Q9NXE6, Q9NYG0, Q9NZM2, Q9ULG4	Gene names	ITSN2, KIAA1256, SH3D1B, SWAP
Domain Architecture
Description	Intersectin-2 (SH3 domain-containing protein 1B) (SH3P18) (SH3P18-like WASP-associated protein).

M3K9_HUMAN
θ value	5.27518 (rank : 17)	NC score	0.015892 (rank : 52)
Query Neighborhood Hits	19	Target Neighborhood Hits	1123	Shared Neighborhood Hits	14
SwissProt Accessions	P80192, Q6EH31, Q9H2N5	Gene names	MAP3K9, MLK1, PRKE1
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase 9 (EC 2.7.11.25) (Mixed lineage kinase 1).

ITSN1_HUMAN
θ value	8.99809 (rank : 18)	NC score	0.033871 (rank : 50)
Query Neighborhood Hits	19	Target Neighborhood Hits	1757	Shared Neighborhood Hits	14
SwissProt Accessions	Q15811, O95216, Q9UET5, Q9UK60, Q9UNK1, Q9UNK2, Q9UQ92	Gene names	ITSN1, ITSN, SH3D1A
Domain Architecture
Description	Intersectin-1 (SH3 domain-containing protein 1A) (SH3P17).

M3KL4_HUMAN
θ value	8.99809 (rank : 19)	NC score	0.016793 (rank : 51)
Query Neighborhood Hits	19	Target Neighborhood Hits	1087	Shared Neighborhood Hits	14
SwissProt Accessions	Q5TCX8, Q5TCX7, Q5TCX9, Q8WWN1, Q8WWN2, Q96JM1	Gene names	MLK4, KIAA1804
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase (EC 2.7.11.25) (Mixed lineage kinase 4).

ARHG1_HUMAN
θ value	θ > 10 (rank : 20)	NC score	0.054080 (rank : 37)
Query Neighborhood Hits	19	Target Neighborhood Hits	176	Shared Neighborhood Hits	8
SwissProt Accessions	Q92888, O00513, Q8N4J4, Q96BF4, Q96F17, Q9BSB1	Gene names	ARHGEF1
Domain Architecture
Description	Rho guanine nucleotide exchange factor 1 (p115-RhoGEF) (p115RhoGEF) (115 kDa guanine nucleotide exchange factor) (Sub1.5).

ARHG1_MOUSE
θ value	θ > 10 (rank : 21)	NC score	0.050410 (rank : 46)
Query Neighborhood Hits	19	Target Neighborhood Hits	266	Shared Neighborhood Hits	8
SwissProt Accessions	Q61210, O89074, Q80YE8, Q80YE9, Q91VL3	Gene names	Arhgef1, Lbcl2, Lsc
Domain Architecture
Description	Rho guanine nucleotide exchange factor 1 (Lymphoid blast crisis-like 2) (Lbc's second cousin).

ARHG3_HUMAN
θ value	θ > 10 (rank : 22)	NC score	0.056426 (rank : 32)
Query Neighborhood Hits	19	Target Neighborhood Hits	82	Shared Neighborhood Hits	8
SwissProt Accessions	Q9NR81, Q6NUN3, Q7Z4U2, Q7Z5T2, Q9H7T4	Gene names	ARHGEF3
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 3 (Exchange factor found in platelets and leukemic and neuronal tissues) (XPLN).

ARHG3_MOUSE
θ value	θ > 10 (rank : 23)	NC score	0.056207 (rank : 33)
Query Neighborhood Hits	19	Target Neighborhood Hits	85	Shared Neighborhood Hits	8
SwissProt Accessions	Q91X46, Q8CDM0, Q91VY4, Q99K14, Q9DC31	Gene names	Arhgef3
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 3.

ARHG4_HUMAN
θ value	θ > 10 (rank : 24)	NC score	0.066009 (rank : 21)
Query Neighborhood Hits	19	Target Neighborhood Hits	242	Shared Neighborhood Hits	13
SwissProt Accessions	Q9NR80, Q9HDC6, Q9UPP0	Gene names	ARHGEF4, KIAA1112
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 4 (APC-stimulated guanine nucleotide exchange factor) (Asef).

ARHG4_MOUSE
θ value	θ > 10 (rank : 25)	NC score	0.068629 (rank : 19)
Query Neighborhood Hits	19	Target Neighborhood Hits	185	Shared Neighborhood Hits	12
SwissProt Accessions	Q7TNR9, Q80TJ6	Gene names	Arhgef4, Kiaa1112
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 4 (APC-stimulated guanine nucleotide exchange factor) (Asef).

ARHG6_HUMAN
θ value	θ > 10 (rank : 26)	NC score	0.057662 (rank : 25)
Query Neighborhood Hits	19	Target Neighborhood Hits	376	Shared Neighborhood Hits	13
SwissProt Accessions	Q15052, Q15396, Q5JQ66, Q86XH0	Gene names	ARHGEF6, COOL2, KIAA0006, PIXA
Domain Architecture
Description	Rho guanine nucleotide exchange factor 6 (Rac/Cdc42 guanine nucleotide exchange factor 6) (PAK-interacting exchange factor alpha) (Alpha-Pix) (COOL-2).

ARHG6_MOUSE
θ value	θ > 10 (rank : 27)	NC score	0.052306 (rank : 41)
Query Neighborhood Hits	19	Target Neighborhood Hits	394	Shared Neighborhood Hits	13
SwissProt Accessions	Q8K4I3, Q8C9V4	Gene names	Arhgef6
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 6 (Rac/Cdc42 guanine nucleotide exchange factor 6).

ARHG8_HUMAN
θ value	θ > 10 (rank : 28)	NC score	0.052108 (rank : 42)
Query Neighborhood Hits	19	Target Neighborhood Hits	85	Shared Neighborhood Hits	8
SwissProt Accessions	Q7Z628, Q12773, Q96D82, Q99903, Q9UEN6	Gene names	NET1, ARHGEF8
Domain Architecture	No domain graphic available
Description	Neuroepithelial cell-transforming gene 1 protein (p65 Net1 proto- oncogene) (Rho guanine nucleotide exchange factor 8).

ARHG9_HUMAN
θ value	θ > 10 (rank : 29)	NC score	0.069159 (rank : 18)
Query Neighborhood Hits	19	Target Neighborhood Hits	235	Shared Neighborhood Hits	13
SwissProt Accessions	O43307, Q5JSL6	Gene names	ARHGEF9, KIAA0424
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 9 (Rac/Cdc42 guanine nucleotide exchange factor 9) (Collybistin) (PEM-2 homolog).

ARHG9_MOUSE
θ value	θ > 10 (rank : 30)	NC score	0.069437 (rank : 17)
Query Neighborhood Hits	19	Target Neighborhood Hits	234	Shared Neighborhood Hits	13
SwissProt Accessions	Q3UTH8, Q3TQ60, Q80U06, Q8CAF9	Gene names	Arhgef9, Kiaa0424
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 9 (Rac/Cdc42 guanine nucleotide exchange factor 9) (Collybistin).

ARHGC_MOUSE
θ value	θ > 10 (rank : 31)	NC score	0.050407 (rank : 47)
Query Neighborhood Hits	19	Target Neighborhood Hits	344	Shared Neighborhood Hits	9
SwissProt Accessions	Q8R4H2, Q80U18	Gene names	Arhgef12, Kiaa0382, Larg
Domain Architecture
Description	Rho guanine nucleotide exchange factor 12 (Leukemia-associated RhoGEF).

CRKL_HUMAN
θ value	θ > 10 (rank : 32)	NC score	0.055647 (rank : 35)
Query Neighborhood Hits	19	Target Neighborhood Hits	313	Shared Neighborhood Hits	13
SwissProt Accessions	P46109	Gene names	CRKL
Domain Architecture
Description	Crk-like protein.

CRKL_MOUSE
θ value	θ > 10 (rank : 33)	NC score	0.054862 (rank : 36)
Query Neighborhood Hits	19	Target Neighborhood Hits	307	Shared Neighborhood Hits	13
SwissProt Accessions	P47941, Q3TQ18, Q8BGC5	Gene names	Crkl, Crkol
Domain Architecture
Description	Crk-like protein.

DNMBP_HUMAN
θ value	θ > 10 (rank : 34)	NC score	0.050666 (rank : 44)
Query Neighborhood Hits	19	Target Neighborhood Hits	413	Shared Neighborhood Hits	13
SwissProt Accessions	Q6XZF7, Q8IVY3, Q9Y2L3	Gene names	DNMBP, KIAA1010
Domain Architecture	No domain graphic available
Description	Dynamin-binding protein (Scaffold protein Tuba).

DNMBP_MOUSE
θ value	θ > 10 (rank : 35)	NC score	0.055780 (rank : 34)
Query Neighborhood Hits	19	Target Neighborhood Hits	435	Shared Neighborhood Hits	13
SwissProt Accessions	Q6TXD4, Q6ZQ05, Q8CEW8, Q8R0Y2	Gene names	Dnmbp, Kiaa1010
Domain Architecture	No domain graphic available
Description	Dynamin-binding protein (Scaffold protein Tuba).

ECT2_HUMAN
θ value	θ > 10 (rank : 36)	NC score	0.058826 (rank : 24)
Query Neighborhood Hits	19	Target Neighborhood Hits	98	Shared Neighborhood Hits	8
SwissProt Accessions	Q9H8V3, Q9NSV8, Q9NVW9	Gene names	ECT2
Domain Architecture
Description	ECT2 protein (Epithelial cell-transforming sequence 2 oncogene).

ECT2_MOUSE
θ value	θ > 10 (rank : 37)	NC score	0.061089 (rank : 22)
Query Neighborhood Hits	19	Target Neighborhood Hits	98	Shared Neighborhood Hits	8
SwissProt Accessions	Q07139	Gene names	Ect2
Domain Architecture
Description	ECT2 protein (Epithelial cell-transforming sequence 2 oncogene).

GRAP_HUMAN
θ value	θ > 10 (rank : 38)	NC score	0.067936 (rank : 20)
Query Neighborhood Hits	19	Target Neighborhood Hits	307	Shared Neighborhood Hits	13
SwissProt Accessions	Q13588	Gene names	GRAP
Domain Architecture
Description	GRB2-related adapter protein.

GRAP_MOUSE
θ value	θ > 10 (rank : 39)	NC score	0.069615 (rank : 16)
Query Neighborhood Hits	19	Target Neighborhood Hits	309	Shared Neighborhood Hits	13
SwissProt Accessions	Q9CX99, Q3U545	Gene names	Grap
Domain Architecture	No domain graphic available
Description	GRB2-related adapter protein.

GRB2_HUMAN
θ value	θ > 10 (rank : 40)	NC score	0.056739 (rank : 28)
Query Neighborhood Hits	19	Target Neighborhood Hits	310	Shared Neighborhood Hits	13
SwissProt Accessions	P62993, P29354, Q14450, Q63057, Q63059	Gene names	GRB2, ASH
Domain Architecture	No domain graphic available
Description	Growth factor receptor-bound protein 2 (Adapter protein GRB2) (SH2/SH3 adapter GRB2) (Protein Ash).

GRB2_MOUSE
θ value	θ > 10 (rank : 41)	NC score	0.056648 (rank : 30)
Query Neighborhood Hits	19	Target Neighborhood Hits	312	Shared Neighborhood Hits	13
SwissProt Accessions	Q60631, Q61240	Gene names	Grb2
Domain Architecture
Description	Growth factor receptor-bound protein 2 (Adapter protein GRB2) (SH2/SH3 adapter GRB2).

MCF2L_MOUSE
θ value	θ > 10 (rank : 42)	NC score	0.056470 (rank : 31)
Query Neighborhood Hits	19	Target Neighborhood Hits	255	Shared Neighborhood Hits	9
SwissProt Accessions	Q64096	Gene names	Mcf2l, Dbs
Domain Architecture
Description	Guanine nucleotide exchange factor DBS (DBL's big sister) (MCF2- transforming sequence-like protein).

NGEF_MOUSE
θ value	θ > 10 (rank : 43)	NC score	0.051248 (rank : 43)
Query Neighborhood Hits	19	Target Neighborhood Hits	228	Shared Neighborhood Hits	11
SwissProt Accessions	Q8CHT1, Q8R204, Q923H2, Q9JHT9	Gene names	Ngef
Domain Architecture	No domain graphic available
Description	Ephexin-1 (Eph-interacting exchange protein) (Neuronal guanine nucleotide exchange factor).

PKHG1_HUMAN
θ value	θ > 10 (rank : 44)	NC score	0.070058 (rank : 15)
Query Neighborhood Hits	19	Target Neighborhood Hits	174	Shared Neighborhood Hits	8
SwissProt Accessions	Q9ULL1, Q5T1F2	Gene names	PLEKHG1, KIAA1209
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family G member 1.

PLCG1_HUMAN
θ value	θ > 10 (rank : 45)	NC score	0.052661 (rank : 38)
Query Neighborhood Hits	19	Target Neighborhood Hits	293	Shared Neighborhood Hits	13
SwissProt Accessions	P19174, Q2V575	Gene names	PLCG1, PLC1
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 1 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-1) (Phospholipase C-gamma-1) (PLC-II) (PLC-148).

PLCG1_MOUSE
θ value	θ > 10 (rank : 46)	NC score	0.052438 (rank : 40)
Query Neighborhood Hits	19	Target Neighborhood Hits	314	Shared Neighborhood Hits	13
SwissProt Accessions	Q62077, Q6P1G1	Gene names	Plcg1, Plcg-1
Domain Architecture	No domain graphic available
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 1 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-1) (Phospholipase C-gamma-1) (PLC-II) (PLC-148).

PLCG2_HUMAN
θ value	θ > 10 (rank : 47)	NC score	0.057532 (rank : 26)
Query Neighborhood Hits	19	Target Neighborhood Hits	280	Shared Neighborhood Hits	13
SwissProt Accessions	P16885, Q969T5	Gene names	PLCG2
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 2 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-2) (Phospholipase C-gamma-2) (PLC-IV).

PREX1_HUMAN
θ value	θ > 10 (rank : 48)	NC score	0.060346 (rank : 23)
Query Neighborhood Hits	19	Target Neighborhood Hits	177	Shared Neighborhood Hits	9
SwissProt Accessions	Q8TCU6, Q5JS95, Q5JS96, Q69YL2, Q7Z2L9, Q9BQH0, Q9BX55, Q9H4Q6, Q9P2D2, Q9UGQ4	Gene names	PREX1, KIAA1415
Domain Architecture
Description	Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein (P-Rex1 protein).

SRBS1_HUMAN
θ value	θ > 10 (rank : 49)	NC score	0.052540 (rank : 39)
Query Neighborhood Hits	19	Target Neighborhood Hits	396	Shared Neighborhood Hits	13
SwissProt Accessions	Q9BX66, Q7LBE5, Q8IVK0, Q8IVQ4, Q96KF3, Q96KF4, Q9BX64, Q9BX65, Q9P2Q0, Q9UFT2, Q9UHN7, Q9Y338	Gene names	SORBS1, KIAA1296, SH3D5
Domain Architecture	No domain graphic available
Description	Sorbin and SH3 domain-containing protein 1 (Ponsin) (c-Cbl-associated protein) (CAP) (SH3 domain protein 5) (SH3P12).

SRBS1_MOUSE
θ value	θ > 10 (rank : 50)	NC score	0.050591 (rank : 45)
Query Neighborhood Hits	19	Target Neighborhood Hits	409	Shared Neighborhood Hits	13
SwissProt Accessions	Q62417, Q80TF8, Q8BZI3, Q8K3Y2, Q921F8, Q9Z0Z8, Q9Z0Z9	Gene names	Sorbs1, Kiaa1296, Sh3d5
Domain Architecture	No domain graphic available
Description	Sorbin and SH3 domain-containing protein 1 (Ponsin) (c-Cbl-associated protein) (CAP) (SH3 domain protein 5) (SH3P12).

TIAM1_HUMAN
θ value	θ > 10 (rank : 51)	NC score	0.056663 (rank : 29)
Query Neighborhood Hits	19	Target Neighborhood Hits	225	Shared Neighborhood Hits	9
SwissProt Accessions	Q13009	Gene names	TIAM1
Domain Architecture
Description	T-lymphoma invasion and metastasis-inducing protein 1 (TIAM-1 protein).

TIAM1_MOUSE
θ value	θ > 10 (rank : 52)	NC score	0.057157 (rank : 27)
Query Neighborhood Hits	19	Target Neighborhood Hits	205	Shared Neighborhood Hits	9
SwissProt Accessions	Q60610	Gene names	Tiam1, Tiam-1
Domain Architecture
Description	T-lymphoma invasion and metastasis-inducing protein 1 (TIAM-1 protein).

Hits sorted by NC score

MIA_HUMAN
NC score	0.999962 (rank : 1)	θ value	1.22964e-73 (rank : 1)
Query Neighborhood Hits	19	Target Neighborhood Hits	19	Shared Neighborhood Hits	19
SwissProt Accessions	Q16674	Gene names	MIA
Domain Architecture
Description	Melanoma-derived growth regulatory protein precursor (Melanoma inhibitory activity).

MIA_MOUSE
NC score	0.994854 (rank : 2)	θ value	9.45883e-58 (rank : 2)
Query Neighborhood Hits	19	Target Neighborhood Hits	17	Shared Neighborhood Hits	15
SwissProt Accessions	Q61865, O09086, P97495	Gene names	Mia, Cdrap, Mia1
Domain Architecture
Description	Melanoma-derived growth regulatory protein precursor (Melanoma inhibitory activity) (Cartilage-derived retinoic acid-sensitive protein) (CD-RAP).

OTOR_MOUSE
NC score	0.891046 (rank : 3)	θ value	4.43474e-23 (rank : 3)
Query Neighborhood Hits	19	Target Neighborhood Hits	15	Shared Neighborhood Hits	14
SwissProt Accessions	Q9JIE3	Gene names	Otor, Mial
Domain Architecture
Description	Otoraplin precursor (Melanoma inhibitory activity-like protein).

OTOR_HUMAN
NC score	0.871820 (rank : 4)	θ value	3.17815e-21 (rank : 4)
Query Neighborhood Hits	19	Target Neighborhood Hits	12	Shared Neighborhood Hits	12
SwissProt Accessions	Q9NRC9	Gene names	OTOR, FDP, MIAL
Domain Architecture
Description	Otoraplin precursor (Fibrocyte-derived protein) (Melanoma inhibitory activity-like protein).

MIA2_HUMAN
NC score	0.584551 (rank : 5)	θ value	1.133e-10 (rank : 5)
Query Neighborhood Hits	19	Target Neighborhood Hits	28	Shared Neighborhood Hits	6
SwissProt Accessions	Q96PC5, Q9H6C1	Gene names	MIA2
Domain Architecture	No domain graphic available
Description	Melanoma inhibitory activity protein 2 precursor.

MIA2_MOUSE
NC score	0.564074 (rank : 6)	θ value	5.62301e-10 (rank : 6)
Query Neighborhood Hits	19	Target Neighborhood Hits	109	Shared Neighborhood Hits	11
SwissProt Accessions	Q91ZV0	Gene names	Mia2
Domain Architecture	No domain graphic available
Description	Melanoma inhibitory activity protein 2 precursor.

VAV3_HUMAN
NC score	0.207343 (rank : 7)	θ value	9.29e-05 (rank : 7)
Query Neighborhood Hits	19	Target Neighborhood Hits	398	Shared Neighborhood Hits	17
SwissProt Accessions	Q9UKW4, O95230, Q9Y5X8	Gene names	VAV3
Domain Architecture
Description	Protein vav-3.

VAV3_MOUSE
NC score	0.204633 (rank : 8)	θ value	0.00020696 (rank : 8)
Query Neighborhood Hits	19	Target Neighborhood Hits	404	Shared Neighborhood Hits	17
SwissProt Accessions	Q9R0C8, Q7TS85	Gene names	Vav3
Domain Architecture
Description	Protein vav-3.

VAV2_MOUSE
NC score	0.192257 (rank : 9)	θ value	0.00298849 (rank : 10)
Query Neighborhood Hits	19	Target Neighborhood Hits	456	Shared Neighborhood Hits	17
SwissProt Accessions	Q60992	Gene names	Vav2
Domain Architecture
Description	Protein vav-2.

VAV2_HUMAN
NC score	0.190929 (rank : 10)	θ value	0.00298849 (rank : 9)
Query Neighborhood Hits	19	Target Neighborhood Hits	453	Shared Neighborhood Hits	17
SwissProt Accessions	P52735	Gene names	VAV2
Domain Architecture
Description	Protein vav-2.

VAV_MOUSE
NC score	0.175658 (rank : 11)	θ value	0.21417 (rank : 13)
Query Neighborhood Hits	19	Target Neighborhood Hits	430	Shared Neighborhood Hits	17
SwissProt Accessions	P27870, Q8BTV7	Gene names	Vav1, Vav
Domain Architecture
Description	Proto-oncogene vav (p95vav).

VAV_HUMAN
NC score	0.169819 (rank : 12)	θ value	0.62314 (rank : 14)
Query Neighborhood Hits	19	Target Neighborhood Hits	452	Shared Neighborhood Hits	17
SwissProt Accessions	P15498, Q15860	Gene names	VAV1, VAV
Domain Architecture
Description	Proto-oncogene vav.

AHI1_HUMAN
NC score	0.115380 (rank : 13)	θ value	0.0563607 (rank : 11)
Query Neighborhood Hits	19	Target Neighborhood Hits	537	Shared Neighborhood Hits	17
SwissProt Accessions	Q8N157, Q504T3, Q5TCP9, Q6P098, Q6PIT6, Q8NDX0, Q9H0H2	Gene names	AHI1
Domain Architecture	No domain graphic available
Description	Jouberin (Abelson helper integration site 1 protein homolog) (AHI-1).

AHI1_MOUSE
NC score	0.105405 (rank : 14)	θ value	0.0563607 (rank : 12)
Query Neighborhood Hits	19	Target Neighborhood Hits	496	Shared Neighborhood Hits	16
SwissProt Accessions	Q8K3E5, Q7TNV2, Q9CVY1	Gene names	Ahi1
Domain Architecture	No domain graphic available
Description	Jouberin (Abelson helper integration site 1 protein) (AHI-1).

PKHG1_HUMAN
NC score	0.070058 (rank : 15)	θ value	θ > 10 (rank : 44)
Query Neighborhood Hits	19	Target Neighborhood Hits	174	Shared Neighborhood Hits	8
SwissProt Accessions	Q9ULL1, Q5T1F2	Gene names	PLEKHG1, KIAA1209
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family G member 1.

GRAP_MOUSE
NC score	0.069615 (rank : 16)	θ value	θ > 10 (rank : 39)
Query Neighborhood Hits	19	Target Neighborhood Hits	309	Shared Neighborhood Hits	13
SwissProt Accessions	Q9CX99, Q3U545	Gene names	Grap
Domain Architecture	No domain graphic available
Description	GRB2-related adapter protein.

ARHG9_MOUSE
NC score	0.069437 (rank : 17)	θ value	θ > 10 (rank : 30)
Query Neighborhood Hits	19	Target Neighborhood Hits	234	Shared Neighborhood Hits	13
SwissProt Accessions	Q3UTH8, Q3TQ60, Q80U06, Q8CAF9	Gene names	Arhgef9, Kiaa0424
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 9 (Rac/Cdc42 guanine nucleotide exchange factor 9) (Collybistin).

ARHG9_HUMAN
NC score	0.069159 (rank : 18)	θ value	θ > 10 (rank : 29)
Query Neighborhood Hits	19	Target Neighborhood Hits	235	Shared Neighborhood Hits	13
SwissProt Accessions	O43307, Q5JSL6	Gene names	ARHGEF9, KIAA0424
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 9 (Rac/Cdc42 guanine nucleotide exchange factor 9) (Collybistin) (PEM-2 homolog).

ARHG4_MOUSE
NC score	0.068629 (rank : 19)	θ value	θ > 10 (rank : 25)
Query Neighborhood Hits	19	Target Neighborhood Hits	185	Shared Neighborhood Hits	12
SwissProt Accessions	Q7TNR9, Q80TJ6	Gene names	Arhgef4, Kiaa1112
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 4 (APC-stimulated guanine nucleotide exchange factor) (Asef).

GRAP_HUMAN
NC score	0.067936 (rank : 20)	θ value	θ > 10 (rank : 38)
Query Neighborhood Hits	19	Target Neighborhood Hits	307	Shared Neighborhood Hits	13
SwissProt Accessions	Q13588	Gene names	GRAP
Domain Architecture
Description	GRB2-related adapter protein.

ARHG4_HUMAN
NC score	0.066009 (rank : 21)	θ value	θ > 10 (rank : 24)
Query Neighborhood Hits	19	Target Neighborhood Hits	242	Shared Neighborhood Hits	13
SwissProt Accessions	Q9NR80, Q9HDC6, Q9UPP0	Gene names	ARHGEF4, KIAA1112
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 4 (APC-stimulated guanine nucleotide exchange factor) (Asef).

ECT2_MOUSE
NC score	0.061089 (rank : 22)	θ value	θ > 10 (rank : 37)
Query Neighborhood Hits	19	Target Neighborhood Hits	98	Shared Neighborhood Hits	8
SwissProt Accessions	Q07139	Gene names	Ect2
Domain Architecture
Description	ECT2 protein (Epithelial cell-transforming sequence 2 oncogene).

PREX1_HUMAN
NC score	0.060346 (rank : 23)	θ value	θ > 10 (rank : 48)
Query Neighborhood Hits	19	Target Neighborhood Hits	177	Shared Neighborhood Hits	9
SwissProt Accessions	Q8TCU6, Q5JS95, Q5JS96, Q69YL2, Q7Z2L9, Q9BQH0, Q9BX55, Q9H4Q6, Q9P2D2, Q9UGQ4	Gene names	PREX1, KIAA1415
Domain Architecture
Description	Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein (P-Rex1 protein).

ECT2_HUMAN
NC score	0.058826 (rank : 24)	θ value	θ > 10 (rank : 36)
Query Neighborhood Hits	19	Target Neighborhood Hits	98	Shared Neighborhood Hits	8
SwissProt Accessions	Q9H8V3, Q9NSV8, Q9NVW9	Gene names	ECT2
Domain Architecture
Description	ECT2 protein (Epithelial cell-transforming sequence 2 oncogene).

ARHG6_HUMAN
NC score	0.057662 (rank : 25)	θ value	θ > 10 (rank : 26)
Query Neighborhood Hits	19	Target Neighborhood Hits	376	Shared Neighborhood Hits	13
SwissProt Accessions	Q15052, Q15396, Q5JQ66, Q86XH0	Gene names	ARHGEF6, COOL2, KIAA0006, PIXA
Domain Architecture
Description	Rho guanine nucleotide exchange factor 6 (Rac/Cdc42 guanine nucleotide exchange factor 6) (PAK-interacting exchange factor alpha) (Alpha-Pix) (COOL-2).

PLCG2_HUMAN
NC score	0.057532 (rank : 26)	θ value	θ > 10 (rank : 47)
Query Neighborhood Hits	19	Target Neighborhood Hits	280	Shared Neighborhood Hits	13
SwissProt Accessions	P16885, Q969T5	Gene names	PLCG2
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 2 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-2) (Phospholipase C-gamma-2) (PLC-IV).

TIAM1_MOUSE
NC score	0.057157 (rank : 27)	θ value	θ > 10 (rank : 52)
Query Neighborhood Hits	19	Target Neighborhood Hits	205	Shared Neighborhood Hits	9
SwissProt Accessions	Q60610	Gene names	Tiam1, Tiam-1
Domain Architecture
Description	T-lymphoma invasion and metastasis-inducing protein 1 (TIAM-1 protein).

GRB2_HUMAN
NC score	0.056739 (rank : 28)	θ value	θ > 10 (rank : 40)
Query Neighborhood Hits	19	Target Neighborhood Hits	310	Shared Neighborhood Hits	13
SwissProt Accessions	P62993, P29354, Q14450, Q63057, Q63059	Gene names	GRB2, ASH
Domain Architecture	No domain graphic available
Description	Growth factor receptor-bound protein 2 (Adapter protein GRB2) (SH2/SH3 adapter GRB2) (Protein Ash).

TIAM1_HUMAN
NC score	0.056663 (rank : 29)	θ value	θ > 10 (rank : 51)
Query Neighborhood Hits	19	Target Neighborhood Hits	225	Shared Neighborhood Hits	9
SwissProt Accessions	Q13009	Gene names	TIAM1
Domain Architecture
Description	T-lymphoma invasion and metastasis-inducing protein 1 (TIAM-1 protein).

GRB2_MOUSE
NC score	0.056648 (rank : 30)	θ value	θ > 10 (rank : 41)
Query Neighborhood Hits	19	Target Neighborhood Hits	312	Shared Neighborhood Hits	13
SwissProt Accessions	Q60631, Q61240	Gene names	Grb2
Domain Architecture
Description	Growth factor receptor-bound protein 2 (Adapter protein GRB2) (SH2/SH3 adapter GRB2).

MCF2L_MOUSE
NC score	0.056470 (rank : 31)	θ value	θ > 10 (rank : 42)
Query Neighborhood Hits	19	Target Neighborhood Hits	255	Shared Neighborhood Hits	9
SwissProt Accessions	Q64096	Gene names	Mcf2l, Dbs
Domain Architecture
Description	Guanine nucleotide exchange factor DBS (DBL's big sister) (MCF2- transforming sequence-like protein).

ARHG3_HUMAN
NC score	0.056426 (rank : 32)	θ value	θ > 10 (rank : 22)
Query Neighborhood Hits	19	Target Neighborhood Hits	82	Shared Neighborhood Hits	8
SwissProt Accessions	Q9NR81, Q6NUN3, Q7Z4U2, Q7Z5T2, Q9H7T4	Gene names	ARHGEF3
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 3 (Exchange factor found in platelets and leukemic and neuronal tissues) (XPLN).

ARHG3_MOUSE
NC score	0.056207 (rank : 33)	θ value	θ > 10 (rank : 23)
Query Neighborhood Hits	19	Target Neighborhood Hits	85	Shared Neighborhood Hits	8
SwissProt Accessions	Q91X46, Q8CDM0, Q91VY4, Q99K14, Q9DC31	Gene names	Arhgef3
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 3.

DNMBP_MOUSE
NC score	0.055780 (rank : 34)	θ value	θ > 10 (rank : 35)
Query Neighborhood Hits	19	Target Neighborhood Hits	435	Shared Neighborhood Hits	13
SwissProt Accessions	Q6TXD4, Q6ZQ05, Q8CEW8, Q8R0Y2	Gene names	Dnmbp, Kiaa1010
Domain Architecture	No domain graphic available
Description	Dynamin-binding protein (Scaffold protein Tuba).

CRKL_HUMAN
NC score	0.055647 (rank : 35)	θ value	θ > 10 (rank : 32)
Query Neighborhood Hits	19	Target Neighborhood Hits	313	Shared Neighborhood Hits	13
SwissProt Accessions	P46109	Gene names	CRKL
Domain Architecture
Description	Crk-like protein.

CRKL_MOUSE
NC score	0.054862 (rank : 36)	θ value	θ > 10 (rank : 33)
Query Neighborhood Hits	19	Target Neighborhood Hits	307	Shared Neighborhood Hits	13
SwissProt Accessions	P47941, Q3TQ18, Q8BGC5	Gene names	Crkl, Crkol
Domain Architecture
Description	Crk-like protein.

ARHG1_HUMAN
NC score	0.054080 (rank : 37)	θ value	θ > 10 (rank : 20)
Query Neighborhood Hits	19	Target Neighborhood Hits	176	Shared Neighborhood Hits	8
SwissProt Accessions	Q92888, O00513, Q8N4J4, Q96BF4, Q96F17, Q9BSB1	Gene names	ARHGEF1
Domain Architecture
Description	Rho guanine nucleotide exchange factor 1 (p115-RhoGEF) (p115RhoGEF) (115 kDa guanine nucleotide exchange factor) (Sub1.5).

PLCG1_HUMAN
NC score	0.052661 (rank : 38)	θ value	θ > 10 (rank : 45)
Query Neighborhood Hits	19	Target Neighborhood Hits	293	Shared Neighborhood Hits	13
SwissProt Accessions	P19174, Q2V575	Gene names	PLCG1, PLC1
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 1 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-1) (Phospholipase C-gamma-1) (PLC-II) (PLC-148).

SRBS1_HUMAN
NC score	0.052540 (rank : 39)	θ value	θ > 10 (rank : 49)
Query Neighborhood Hits	19	Target Neighborhood Hits	396	Shared Neighborhood Hits	13
SwissProt Accessions	Q9BX66, Q7LBE5, Q8IVK0, Q8IVQ4, Q96KF3, Q96KF4, Q9BX64, Q9BX65, Q9P2Q0, Q9UFT2, Q9UHN7, Q9Y338	Gene names	SORBS1, KIAA1296, SH3D5
Domain Architecture	No domain graphic available
Description	Sorbin and SH3 domain-containing protein 1 (Ponsin) (c-Cbl-associated protein) (CAP) (SH3 domain protein 5) (SH3P12).

PLCG1_MOUSE
NC score	0.052438 (rank : 40)	θ value	θ > 10 (rank : 46)
Query Neighborhood Hits	19	Target Neighborhood Hits	314	Shared Neighborhood Hits	13
SwissProt Accessions	Q62077, Q6P1G1	Gene names	Plcg1, Plcg-1
Domain Architecture	No domain graphic available
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 1 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-1) (Phospholipase C-gamma-1) (PLC-II) (PLC-148).

ARHG6_MOUSE
NC score	0.052306 (rank : 41)	θ value	θ > 10 (rank : 27)
Query Neighborhood Hits	19	Target Neighborhood Hits	394	Shared Neighborhood Hits	13
SwissProt Accessions	Q8K4I3, Q8C9V4	Gene names	Arhgef6
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 6 (Rac/Cdc42 guanine nucleotide exchange factor 6).

ARHG8_HUMAN
NC score	0.052108 (rank : 42)	θ value	θ > 10 (rank : 28)
Query Neighborhood Hits	19	Target Neighborhood Hits	85	Shared Neighborhood Hits	8
SwissProt Accessions	Q7Z628, Q12773, Q96D82, Q99903, Q9UEN6	Gene names	NET1, ARHGEF8
Domain Architecture	No domain graphic available
Description	Neuroepithelial cell-transforming gene 1 protein (p65 Net1 proto- oncogene) (Rho guanine nucleotide exchange factor 8).

NGEF_MOUSE
NC score	0.051248 (rank : 43)	θ value	θ > 10 (rank : 43)
Query Neighborhood Hits	19	Target Neighborhood Hits	228	Shared Neighborhood Hits	11
SwissProt Accessions	Q8CHT1, Q8R204, Q923H2, Q9JHT9	Gene names	Ngef
Domain Architecture	No domain graphic available
Description	Ephexin-1 (Eph-interacting exchange protein) (Neuronal guanine nucleotide exchange factor).

DNMBP_HUMAN
NC score	0.050666 (rank : 44)	θ value	θ > 10 (rank : 34)
Query Neighborhood Hits	19	Target Neighborhood Hits	413	Shared Neighborhood Hits	13
SwissProt Accessions	Q6XZF7, Q8IVY3, Q9Y2L3	Gene names	DNMBP, KIAA1010
Domain Architecture	No domain graphic available
Description	Dynamin-binding protein (Scaffold protein Tuba).

SRBS1_MOUSE
NC score	0.050591 (rank : 45)	θ value	θ > 10 (rank : 50)
Query Neighborhood Hits	19	Target Neighborhood Hits	409	Shared Neighborhood Hits	13
SwissProt Accessions	Q62417, Q80TF8, Q8BZI3, Q8K3Y2, Q921F8, Q9Z0Z8, Q9Z0Z9	Gene names	Sorbs1, Kiaa1296, Sh3d5
Domain Architecture	No domain graphic available
Description	Sorbin and SH3 domain-containing protein 1 (Ponsin) (c-Cbl-associated protein) (CAP) (SH3 domain protein 5) (SH3P12).

ARHG1_MOUSE
NC score	0.050410 (rank : 46)	θ value	θ > 10 (rank : 21)
Query Neighborhood Hits	19	Target Neighborhood Hits	266	Shared Neighborhood Hits	8
SwissProt Accessions	Q61210, O89074, Q80YE8, Q80YE9, Q91VL3	Gene names	Arhgef1, Lbcl2, Lsc
Domain Architecture
Description	Rho guanine nucleotide exchange factor 1 (Lymphoid blast crisis-like 2) (Lbc's second cousin).

ARHGC_MOUSE
NC score	0.050407 (rank : 47)	θ value	θ > 10 (rank : 31)
Query Neighborhood Hits	19	Target Neighborhood Hits	344	Shared Neighborhood Hits	9
SwissProt Accessions	Q8R4H2, Q80U18	Gene names	Arhgef12, Kiaa0382, Larg
Domain Architecture
Description	Rho guanine nucleotide exchange factor 12 (Leukemia-associated RhoGEF).

ITSN2_HUMAN
NC score	0.045846 (rank : 48)	θ value	5.27518 (rank : 16)
Query Neighborhood Hits	19	Target Neighborhood Hits	1173	Shared Neighborhood Hits	16
SwissProt Accessions	Q9NZM3, O95062, Q15812, Q9HAK4, Q9NXE6, Q9NYG0, Q9NZM2, Q9ULG4	Gene names	ITSN2, KIAA1256, SH3D1B, SWAP
Domain Architecture
Description	Intersectin-2 (SH3 domain-containing protein 1B) (SH3P18) (SH3P18-like WASP-associated protein).

SHAN1_HUMAN
NC score	0.041887 (rank : 49)	θ value	1.06291 (rank : 15)
Query Neighborhood Hits	19	Target Neighborhood Hits	1041	Shared Neighborhood Hits	13
SwissProt Accessions	Q9Y566, Q9NYW9	Gene names	SHANK1
Domain Architecture
Description	SH3 and multiple ankyrin repeat domains protein 1 (Shank1) (Somatostatin receptor-interacting protein) (SSTR-interacting protein) (SSTRIP).

ITSN1_HUMAN
NC score	0.033871 (rank : 50)	θ value	8.99809 (rank : 18)
Query Neighborhood Hits	19	Target Neighborhood Hits	1757	Shared Neighborhood Hits	14
SwissProt Accessions	Q15811, O95216, Q9UET5, Q9UK60, Q9UNK1, Q9UNK2, Q9UQ92	Gene names	ITSN1, ITSN, SH3D1A
Domain Architecture
Description	Intersectin-1 (SH3 domain-containing protein 1A) (SH3P17).

M3KL4_HUMAN
NC score	0.016793 (rank : 51)	θ value	8.99809 (rank : 19)
Query Neighborhood Hits	19	Target Neighborhood Hits	1087	Shared Neighborhood Hits	14
SwissProt Accessions	Q5TCX8, Q5TCX7, Q5TCX9, Q8WWN1, Q8WWN2, Q96JM1	Gene names	MLK4, KIAA1804
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase (EC 2.7.11.25) (Mixed lineage kinase 4).

M3K9_HUMAN
NC score	0.015892 (rank : 52)	θ value	5.27518 (rank : 17)
Query Neighborhood Hits	19	Target Neighborhood Hits	1123	Shared Neighborhood Hits	14
SwissProt Accessions	P80192, Q6EH31, Q9H2N5	Gene names	MAP3K9, MLK1, PRKE1
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase 9 (EC 2.7.11.25) (Mixed lineage kinase 1).