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Network neighborhood for query Sequence : UBP16_HUMAN

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UBP16_HUMAN
SwissProt Accessions	Q9Y5T5, Q8NEL3	Gene names	USP16
Domain Architecture
Description	Ubiquitin carboxyl-terminal hydrolase 16 (EC 3.1.2.15) (Ubiquitin thioesterase 16) (Ubiquitin-specific-processing protease 16) (Deubiquitinating enzyme 16) (Ubiquitin-processing protease UBP-M).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

UBP16_HUMAN
θ value	0 (rank : 1)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	126	Target Neighborhood Hits	126	Shared Neighborhood Hits	126
SwissProt Accessions	Q9Y5T5, Q8NEL3	Gene names	USP16
Domain Architecture
Description	Ubiquitin carboxyl-terminal hydrolase 16 (EC 3.1.2.15) (Ubiquitin thioesterase 16) (Ubiquitin-specific-processing protease 16) (Deubiquitinating enzyme 16) (Ubiquitin-processing protease UBP-M).

UBP15_HUMAN
θ value	1.02238e-19 (rank : 2)	NC score	0.813309 (rank : 24)
Query Neighborhood Hits	126	Target Neighborhood Hits	92	Shared Neighborhood Hits	73
SwissProt Accessions	Q9Y4E8, Q9HCA6, Q9UNP0, Q9Y5B5	Gene names	USP15, KIAA0529
Domain Architecture
Description	Ubiquitin carboxyl-terminal hydrolase 15 (EC 3.1.2.15) (Ubiquitin thioesterase 15) (Ubiquitin-specific-processing protease 15) (Deubiquitinating enzyme 15) (Unph-2) (Unph4).

UBP15_MOUSE
θ value	1.02238e-19 (rank : 3)	NC score	0.813665 (rank : 22)
Query Neighborhood Hits	126	Target Neighborhood Hits	88	Shared Neighborhood Hits	73
SwissProt Accessions	Q8R5H1, Q3UL25	Gene names	Usp15
Domain Architecture
Description	Ubiquitin carboxyl-terminal hydrolase 15 (EC 3.1.2.15) (Ubiquitin thioesterase 15) (Ubiquitin-specific-processing protease 15) (Deubiquitinating enzyme 15).

UBP2_MOUSE
θ value	1.33526e-19 (rank : 4)	NC score	0.860029 (rank : 4)
Query Neighborhood Hits	126	Target Neighborhood Hits	86	Shared Neighborhood Hits	73
SwissProt Accessions	O88623, Q6X4T9, Q6X4U1, Q8VD74, Q9JJ87	Gene names	Usp2, Ubp41
Domain Architecture
Description	Ubiquitin carboxyl-terminal hydrolase 2 (EC 3.1.2.15) (Ubiquitin thioesterase 2) (Ubiquitin-specific-processing protease 2) (Deubiquitinating enzyme 2) (41 kDa ubiquitin-specific protease).

UBP3_MOUSE
θ value	3.88503e-19 (rank : 5)	NC score	0.872035 (rank : 2)
Query Neighborhood Hits	126	Target Neighborhood Hits	89	Shared Neighborhood Hits	77
SwissProt Accessions	Q91W36	Gene names	Usp3
Domain Architecture
Description	Ubiquitin carboxyl-terminal hydrolase 3 (EC 3.1.2.15) (Ubiquitin thioesterase 3) (Ubiquitin-specific-processing protease 3) (Deubiquitinating enzyme 3).

UBP4_HUMAN
θ value	5.60996e-18 (rank : 6)	NC score	0.808516 (rank : 26)
Query Neighborhood Hits	126	Target Neighborhood Hits	89	Shared Neighborhood Hits	73
SwissProt Accessions	Q13107, O43452, O43453	Gene names	USP4, UNP, UNPH
Domain Architecture
Description	Ubiquitin carboxyl-terminal hydrolase 4 (EC 3.1.2.15) (Ubiquitin thioesterase 4) (Ubiquitin-specific-processing protease 4) (Deubiquitinating enzyme 4) (Ubiquitous nuclear protein homolog).

UBP49_MOUSE
θ value	9.56915e-18 (rank : 7)	NC score	0.836122 (rank : 15)
Query Neighborhood Hits	126	Target Neighborhood Hits	91	Shared Neighborhood Hits	78
SwissProt Accessions	Q6P9L4	Gene names	Usp49
Domain Architecture	No domain graphic available
Description	Ubiquitin carboxyl-terminal hydrolase 49 (EC 3.1.2.15) (Ubiquitin thioesterase 49) (Ubiquitin-specific-processing protease 49) (Deubiquitinating enzyme 49).

UBP2_HUMAN
θ value	1.63225e-17 (rank : 8)	NC score	0.856254 (rank : 5)
Query Neighborhood Hits	126	Target Neighborhood Hits	84	Shared Neighborhood Hits	73
SwissProt Accessions	O75604, Q96MB9, Q9BQ21	Gene names	USP2, UBP41
Domain Architecture
Description	Ubiquitin carboxyl-terminal hydrolase 2 (EC 3.1.2.15) (Ubiquitin thioesterase 2) (Ubiquitin-specific-processing protease 2) (Deubiquitinating enzyme 2) (41 kDa ubiquitin-specific protease).

UBP49_HUMAN
θ value	2.13179e-17 (rank : 9)	NC score	0.833487 (rank : 16)
Query Neighborhood Hits	126	Target Neighborhood Hits	100	Shared Neighborhood Hits	77
SwissProt Accessions	Q70CQ1, Q96CK4	Gene names	USP49
Domain Architecture	No domain graphic available
Description	Ubiquitin carboxyl-terminal hydrolase 49 (EC 3.1.2.15) (Ubiquitin thioesterase 49) (Ubiquitin-specific-processing protease 49) (Deubiquitinating enzyme 49).

UBP22_MOUSE
θ value	2.7842e-17 (rank : 10)	NC score	0.845582 (rank : 8)
Query Neighborhood Hits	126	Target Neighborhood Hits	87	Shared Neighborhood Hits	75
SwissProt Accessions	Q5DU02, Q5SU81, Q66JV8	Gene names	Usp22, Kiaa1063
Domain Architecture	No domain graphic available
Description	Ubiquitin carboxyl-terminal hydrolase 22 (EC 3.1.2.15) (Ubiquitin thioesterase 22) (Ubiquitin-specific-processing protease 22) (Deubiquitinating enzyme 22).

UBP51_HUMAN
θ value	3.63628e-17 (rank : 11)	NC score	0.842914 (rank : 9)
Query Neighborhood Hits	126	Target Neighborhood Hits	162	Shared Neighborhood Hits	78
SwissProt Accessions	Q70EK9, Q8IWJ8	Gene names	USP51
Domain Architecture	No domain graphic available
Description	Ubiquitin carboxyl-terminal hydrolase 51 (EC 3.1.2.15) (Ubiquitin thioesterase 51) (Ubiquitin-specific-processing protease 51) (Deubiquitinating enzyme 51).

UBP22_HUMAN
θ value	6.20254e-17 (rank : 12)	NC score	0.847720 (rank : 7)
Query Neighborhood Hits	126	Target Neighborhood Hits	87	Shared Neighborhood Hits	77
SwissProt Accessions	Q9UPT9	Gene names	USP22, KIAA1063, USP3L
Domain Architecture	No domain graphic available
Description	Ubiquitin carboxyl-terminal hydrolase 22 (EC 3.1.2.15) (Ubiquitin thioesterase 22) (Ubiquitin-specific-processing protease 22) (Deubiquitinating enzyme 22).

UBP32_HUMAN
θ value	8.10077e-17 (rank : 13)	NC score	0.728526 (rank : 37)
Query Neighborhood Hits	126	Target Neighborhood Hits	170	Shared Neighborhood Hits	73
SwissProt Accessions	Q8NFA0, Q9BX85, Q9Y591	Gene names	USP32, USP10
Domain Architecture
Description	Ubiquitin carboxyl-terminal hydrolase 32 (EC 3.1.2.15) (Ubiquitin thioesterase 32) (Ubiquitin-specific-processing protease 32) (Deubiquitinating enzyme 32) (NY-REN-60 antigen).

UBP4_MOUSE
θ value	8.10077e-17 (rank : 14)	NC score	0.805704 (rank : 27)
Query Neighborhood Hits	126	Target Neighborhood Hits	90	Shared Neighborhood Hits	73
SwissProt Accessions	P35123, O54704	Gene names	Usp4, Unp
Domain Architecture
Description	Ubiquitin carboxyl-terminal hydrolase 4 (EC 3.1.2.15) (Ubiquitin thioesterase 4) (Ubiquitin-specific-processing protease 4) (Deubiquitinating enzyme 4) (Ubiquitous nuclear protein).

UBP6_HUMAN
θ value	8.10077e-17 (rank : 15)	NC score	0.688422 (rank : 43)
Query Neighborhood Hits	126	Target Neighborhood Hits	188	Shared Neighborhood Hits	73
SwissProt Accessions	P35125, Q15634, Q86WP6, Q8IWT4	Gene names	USP6, TRE2
Domain Architecture
Description	Ubiquitin carboxyl-terminal hydrolase 6 (EC 3.1.2.15) (Ubiquitin thioesterase 6) (Ubiquitin-specific-processing protease 6) (Deubiquitinating enzyme 6) (Proto-oncogene TRE-2).

UBP8_MOUSE
θ value	8.10077e-17 (rank : 16)	NC score	0.832721 (rank : 17)
Query Neighborhood Hits	126	Target Neighborhood Hits	362	Shared Neighborhood Hits	83
SwissProt Accessions	Q80U87, Q80YP2, Q8R0D3, Q9EQU1, Q9WVP5	Gene names	Usp8, Kiaa0055, Ubpy
Domain Architecture
Description	Ubiquitin carboxyl-terminal hydrolase 8 (EC 3.1.2.15) (Ubiquitin thioesterase 8) (Ubiquitin-specific-processing protease 8) (Deubiquitinating enzyme 8) (mUBPy).

UBP8_HUMAN
θ value	1.38178e-16 (rank : 17)	NC score	0.797811 (rank : 28)
Query Neighborhood Hits	126	Target Neighborhood Hits	751	Shared Neighborhood Hits	97
SwissProt Accessions	P40818, Q7Z3U2, Q86VA0, Q8IWI7	Gene names	USP8, KIAA0055, UBPY
Domain Architecture
Description	Ubiquitin carboxyl-terminal hydrolase 8 (EC 3.1.2.15) (Ubiquitin thioesterase 8) (Ubiquitin-specific-processing protease 8) (Deubiquitinating enzyme 8) (hUBPy).

UBP11_HUMAN
θ value	1.80466e-16 (rank : 18)	NC score	0.812088 (rank : 25)
Query Neighborhood Hits	126	Target Neighborhood Hits	88	Shared Neighborhood Hits	73
SwissProt Accessions	P51784, Q8IUG6, Q9BWE1	Gene names	USP11, UHX1
Domain Architecture
Description	Ubiquitin carboxyl-terminal hydrolase 11 (EC 3.1.2.15) (Ubiquitin thioesterase 11) (Ubiquitin-specific-processing protease 11) (Deubiquitinating enzyme 11).

UBP33_HUMAN
θ value	8.95645e-16 (rank : 19)	NC score	0.838691 (rank : 10)
Query Neighborhood Hits	126	Target Neighborhood Hits	157	Shared Neighborhood Hits	79
SwissProt Accessions	Q8TEY7, Q8TEY6, Q96AV6, Q9H9F0, Q9UPQ5	Gene names	USP33, KIAA1097, VDU1
Domain Architecture
Description	Ubiquitin carboxyl-terminal hydrolase 33 (EC 3.1.2.15) (Ubiquitin thioesterase 33) (Ubiquitin-specific-processing protease 33) (Deubiquitinating enzyme 33) (VHL-interacting deubiquitinating enzyme 1).

UBP44_HUMAN
θ value	1.16975e-15 (rank : 20)	NC score	0.838432 (rank : 11)
Query Neighborhood Hits	126	Target Neighborhood Hits	91	Shared Neighborhood Hits	77
SwissProt Accessions	Q9H0E7	Gene names	USP44
Domain Architecture
Description	Ubiquitin carboxyl-terminal hydrolase 44 (EC 3.1.2.15) (Ubiquitin thioesterase 44) (Ubiquitin-specific-processing protease 44) (Deubiquitinating enzyme 44).

UBP1_HUMAN
θ value	4.44505e-15 (rank : 21)	NC score	0.747740 (rank : 36)
Query Neighborhood Hits	126	Target Neighborhood Hits	259	Shared Neighborhood Hits	78
SwissProt Accessions	O94782, Q9UFR0, Q9UNJ3	Gene names	USP1
Domain Architecture
Description	Ubiquitin carboxyl-terminal hydrolase 1 (EC 3.1.2.15) (Ubiquitin thioesterase 1) (Ubiquitin-specific-processing protease 1) (Deubiquitinating enzyme 1) (hUBP).

UBP3_HUMAN
θ value	4.44505e-15 (rank : 22)	NC score	0.863062 (rank : 3)
Query Neighborhood Hits	126	Target Neighborhood Hits	88	Shared Neighborhood Hits	77
SwissProt Accessions	Q9Y6I4	Gene names	USP3
Domain Architecture
Description	Ubiquitin carboxyl-terminal hydrolase 3 (EC 3.1.2.15) (Ubiquitin thioesterase 3) (Ubiquitin-specific-processing protease 3) (Deubiquitinating enzyme 3).

UBP20_HUMAN
θ value	5.8054e-15 (rank : 23)	NC score	0.837957 (rank : 12)
Query Neighborhood Hits	126	Target Neighborhood Hits	113	Shared Neighborhood Hits	77
SwissProt Accessions	Q9Y2K6, Q96LG5, Q9UQN8, Q9UQP0	Gene names	USP20, KIAA1003, LSFR3A
Domain Architecture
Description	Ubiquitin carboxyl-terminal hydrolase 20 (EC 3.1.2.15) (Ubiquitin thioesterase 20) (Ubiquitin-specific-processing protease 20) (Deubiquitinating enzyme 20).

UBP50_MOUSE
θ value	2.20605e-14 (rank : 24)	NC score	0.849195 (rank : 6)
Query Neighborhood Hits	126	Target Neighborhood Hits	80	Shared Neighborhood Hits	73
SwissProt Accessions	Q6P8X6, Q9D558, Q9D9E7	Gene names	Usp50
Domain Architecture	No domain graphic available
Description	Putative ubiquitin carboxyl-terminal hydrolase 50 (EC 3.1.2.15) (Ubiquitin thioesterase 50) (Ubiquitin-specific-processing protease 50) (Deubiquitinating enzyme 50).

UBP36_HUMAN
θ value	1.42992e-13 (rank : 25)	NC score	0.792850 (rank : 30)
Query Neighborhood Hits	126	Target Neighborhood Hits	232	Shared Neighborhood Hits	73
SwissProt Accessions	Q9P275, Q8NDM8, Q9NVC8	Gene names	USP36, KIAA1453
Domain Architecture
Description	Ubiquitin carboxyl-terminal hydrolase 36 (EC 3.1.2.15) (Ubiquitin thioesterase 36) (Ubiquitin-specific-processing protease 36) (Deubiquitinating enzyme 36).

UBP12_HUMAN
θ value	1.86753e-13 (rank : 26)	NC score	0.818916 (rank : 19)
Query Neighborhood Hits	126	Target Neighborhood Hits	85	Shared Neighborhood Hits	73
SwissProt Accessions	O75317	Gene names	USP12, UBH1, USP12L1
Domain Architecture
Description	Ubiquitin carboxyl-terminal hydrolase 12 (EC 3.1.2.15) (Ubiquitin thioesterase 12) (Ubiquitin-specific-processing protease 12) (Deubiquitinating enzyme 12) (Ubiquitin-hydrolyzing enzyme 1).

UBP46_HUMAN
θ value	2.43908e-13 (rank : 27)	NC score	0.815524 (rank : 20)
Query Neighborhood Hits	126	Target Neighborhood Hits	81	Shared Neighborhood Hits	73
SwissProt Accessions	P62068, Q80V95, Q9H7U4, Q9H9T8	Gene names	USP46
Domain Architecture
Description	Ubiquitin carboxyl-terminal hydrolase 46 (EC 3.1.2.15) (Ubiquitin thioesterase 46) (Ubiquitin-specific-processing protease 46) (Deubiquitinating enzyme 46).

UBP46_MOUSE
θ value	2.43908e-13 (rank : 28)	NC score	0.815524 (rank : 21)
Query Neighborhood Hits	126	Target Neighborhood Hits	81	Shared Neighborhood Hits	73
SwissProt Accessions	P62069, Q80V95, Q9H7U4, Q9H9T8	Gene names	Usp46
Domain Architecture
Description	Ubiquitin carboxyl-terminal hydrolase 46 (EC 3.1.2.15) (Ubiquitin thioesterase 46) (Ubiquitin-specific-processing protease 46) (Deubiquitinating enzyme 46).

UBP31_HUMAN
θ value	5.43371e-13 (rank : 29)	NC score	0.769781 (rank : 33)
Query Neighborhood Hits	126	Target Neighborhood Hits	293	Shared Neighborhood Hits	75
SwissProt Accessions	Q70CQ4, Q6AW97, Q6ZTC0, Q6ZTN2, Q9ULL7	Gene names	USP31, KIAA1203
Domain Architecture	No domain graphic available
Description	Ubiquitin carboxyl-terminal hydrolase 31 (EC 3.1.2.15) (Ubiquitin thioesterase 31) (Ubiquitin-specific-processing protease 31) (Deubiquitinating enzyme 31).

UBP42_HUMAN
θ value	7.09661e-13 (rank : 30)	NC score	0.769132 (rank : 34)
Query Neighborhood Hits	126	Target Neighborhood Hits	445	Shared Neighborhood Hits	75
SwissProt Accessions	Q9H9J4, Q3C166, Q6P9B4	Gene names	USP42
Domain Architecture	No domain graphic available
Description	Ubiquitin carboxyl-terminal hydrolase 42 (EC 3.1.2.15) (Ubiquitin thioesterase 42) (Ubiquitin-specific-processing protease 42) (Deubiquitinating enzyme 42).

UBP21_HUMAN
θ value	2.69671e-12 (rank : 31)	NC score	0.836236 (rank : 14)
Query Neighborhood Hits	126	Target Neighborhood Hits	95	Shared Neighborhood Hits	73
SwissProt Accessions	Q9UK80, Q9BTV1, Q9NYN4	Gene names	USP21, USP23
Domain Architecture
Description	Ubiquitin carboxyl-terminal hydrolase 21 (EC 3.1.2.15) (Ubiquitin thioesterase 21) (Ubiquitin-specific-processing protease 21) (Deubiquitinating enzyme 21) (NEDD8-specific protease).

UBP21_MOUSE
θ value	2.69671e-12 (rank : 32)	NC score	0.836403 (rank : 13)
Query Neighborhood Hits	126	Target Neighborhood Hits	101	Shared Neighborhood Hits	73
SwissProt Accessions	Q9QZL6, Q9D0R1	Gene names	Usp21, Usp23
Domain Architecture
Description	Ubiquitin carboxyl-terminal hydrolase 21 (EC 3.1.2.15) (Ubiquitin thioesterase 21) (Ubiquitin-specific-processing protease 21) (Deubiquitinating enzyme 21).

UB17L_HUMAN
θ value	1.33837e-11 (rank : 33)	NC score	0.797400 (rank : 29)
Query Neighborhood Hits	126	Target Neighborhood Hits	83	Shared Neighborhood Hits	72
SwissProt Accessions	Q7RTZ2	Gene names	USP17L
Domain Architecture	No domain graphic available
Description	Ubiquitin carboxyl-terminal hydrolase 17-like protein (EC 3.1.2.15) (Ubiquitin thioesterase 17-like) (Ubiquitin-specific-processing protease 17-like) (Deubiquitinating enzyme 17-like).

UBP43_MOUSE
θ value	1.74796e-11 (rank : 34)	NC score	0.778304 (rank : 31)
Query Neighborhood Hits	126	Target Neighborhood Hits	130	Shared Neighborhood Hits	73
SwissProt Accessions	Q8BUM9, Q8VDP5	Gene names	Usp43
Domain Architecture	No domain graphic available
Description	Ubiquitin carboxyl-terminal hydrolase 43 (EC 3.1.2.15) (Ubiquitin thioesterase 43) (Ubiquitin-specific-processing protease 43) (Deubiquitinating enzyme 43).

UBPW_MOUSE
θ value	3.89403e-11 (rank : 35)	NC score	0.813511 (rank : 23)
Query Neighborhood Hits	126	Target Neighborhood Hits	89	Shared Neighborhood Hits	73
SwissProt Accessions	Q61068	Gene names	Dub1, Dub-1
Domain Architecture
Description	Ubiquitin carboxyl-terminal hydrolase DUB-1 (EC 3.1.2.15) (Ubiquitin thioesterase DUB-1) (Ubiquitin-specific-processing protease DUB-1) (Deubiquitinating enzyme 1).

UBP43_HUMAN
θ value	1.9326e-10 (rank : 36)	NC score	0.773659 (rank : 32)
Query Neighborhood Hits	126	Target Neighborhood Hits	144	Shared Neighborhood Hits	74
SwissProt Accessions	Q70EL4, Q8N2C5, Q96DQ6	Gene names	USP43
Domain Architecture	No domain graphic available
Description	Ubiquitin carboxyl-terminal hydrolase 43 (EC 3.1.2.15) (Ubiquitin thioesterase 43) (Ubiquitin-specific-processing protease 43) (Deubiquitinating enzyme 43).

UBP38_HUMAN
θ value	7.34386e-10 (rank : 37)	NC score	0.672197 (rank : 44)
Query Neighborhood Hits	126	Target Neighborhood Hits	97	Shared Neighborhood Hits	72
SwissProt Accessions	Q8NB14, Q8NDF5, Q96DK6, Q96PZ6, Q9BY55	Gene names	USP38, KIAA1891
Domain Architecture
Description	Ubiquitin carboxyl-terminal hydrolase 38 (EC 3.1.2.15) (Ubiquitin thioesterase 38) (Ubiquitin-specific-processing protease 38) (Deubiquitinating enzyme 38) (HP43.8KD).

UBP50_HUMAN
θ value	7.34386e-10 (rank : 38)	NC score	0.827187 (rank : 18)
Query Neighborhood Hits	126	Target Neighborhood Hits	75	Shared Neighborhood Hits	68
SwissProt Accessions	Q70EL3	Gene names	USP50
Domain Architecture	No domain graphic available
Description	Inactive ubiquitin carboxyl-terminal hydrolase 50 (Inactive ubiquitin- specific peptidase 50).

UBP38_MOUSE
θ value	8.11959e-09 (rank : 39)	NC score	0.669150 (rank : 45)
Query Neighborhood Hits	126	Target Neighborhood Hits	100	Shared Neighborhood Hits	71
SwissProt Accessions	Q8BW70, Q8BWL1, Q8BX03	Gene names	Usp38
Domain Architecture
Description	Ubiquitin carboxyl-terminal hydrolase 38 (EC 3.1.2.15) (Ubiquitin thioesterase 38) (Ubiquitin-specific-processing protease 38) (Deubiquitinating enzyme 38).

UBP18_HUMAN
θ value	1.06045e-08 (rank : 40)	NC score	0.754337 (rank : 35)
Query Neighborhood Hits	126	Target Neighborhood Hits	81	Shared Neighborhood Hits	72
SwissProt Accessions	Q9UMW8, Q9NY71	Gene names	USP18, ISG43
Domain Architecture
Description	Ubl carboxyl-terminal hydrolase 18 (EC 3.1.2.-) (Ubl thioesterase 18) (ISG15-specific-processing protease) (43 kDa ISG15-specific protease) (hUBP43).

UBP35_HUMAN
θ value	1.06045e-08 (rank : 41)	NC score	0.696790 (rank : 42)
Query Neighborhood Hits	126	Target Neighborhood Hits	223	Shared Neighborhood Hits	78
SwissProt Accessions	Q9P2H5	Gene names	USP35, KIAA1372, USP34
Domain Architecture
Description	Ubiquitin carboxyl-terminal hydrolase 35 (EC 3.1.2.15) (Ubiquitin thioesterase 35) (Ubiquitin-specific-processing protease 35) (Deubiquitinating enzyme 35).

BRAP_HUMAN
θ value	1.38499e-08 (rank : 42)	NC score	0.235171 (rank : 75)
Query Neighborhood Hits	126	Target Neighborhood Hits	560	Shared Neighborhood Hits	38
SwissProt Accessions	Q7Z569, O43238, O75341	Gene names	BRAP, RNF52
Domain Architecture	No domain graphic available
Description	BRCA1-associated protein (EC 6.3.2.-) (BRAP2) (Impedes mitogenic signal propagation) (IMP) (RING finger protein 52) (NY-REN-63 antigen).

BRAP_MOUSE
θ value	1.38499e-08 (rank : 43)	NC score	0.265285 (rank : 74)
Query Neighborhood Hits	126	Target Neighborhood Hits	409	Shared Neighborhood Hits	36
SwissProt Accessions	Q99MP8, Q8CC00, Q8CHX1, Q99MP7, Q9CXX8	Gene names	Brap
Domain Architecture	No domain graphic available
Description	BRCA1-associated protein (EC 6.3.2.-) (BRAP2) (Impedes mitogenic signal propagation) (IMP).

UBP37_HUMAN
θ value	5.26297e-08 (rank : 44)	NC score	0.635576 (rank : 51)
Query Neighborhood Hits	126	Target Neighborhood Hits	208	Shared Neighborhood Hits	75
SwissProt Accessions	Q86T82, Q9HCH8	Gene names	USP37, KIAA1594
Domain Architecture
Description	Ubiquitin carboxyl-terminal hydrolase 37 (EC 3.1.2.15) (Ubiquitin thioesterase 37) (Ubiquitin-specific-processing protease 37) (Deubiquitinating enzyme 37).

USP9X_HUMAN
θ value	1.17247e-07 (rank : 45)	NC score	0.595709 (rank : 57)
Query Neighborhood Hits	126	Target Neighborhood Hits	161	Shared Neighborhood Hits	74
SwissProt Accessions	Q93008, O75550, Q8WWT3, Q8WX12	Gene names	USP9X, DFFRX, USP9
Domain Architecture
Description	Probable ubiquitin carboxyl-terminal hydrolase FAF-X (EC 3.1.2.15) (Ubiquitin thioesterase FAF-X) (Ubiquitin-specific-processing protease FAF-X) (Deubiquitinating enzyme FAF-X) (Fat facets protein-related, X- linked) (Ubiquitin-specific protease 9, X chromosome).

UBP48_HUMAN
θ value	1.53129e-07 (rank : 46)	NC score	0.726955 (rank : 39)
Query Neighborhood Hits	126	Target Neighborhood Hits	101	Shared Neighborhood Hits	73
SwissProt Accessions	Q86UV5, Q2M3I4, Q5SZI4, Q5T3T5, Q6NX53, Q8N3F6, Q96F64, Q96IQ3, Q9H5N3, Q9H5T7, Q9NUJ6, Q9NXR0	Gene names	USP48
Domain Architecture	No domain graphic available
Description	Ubiquitin carboxyl-terminal hydrolase 48 (EC 3.1.2.15) (Ubiquitin thioesterase 48) (Ubiquitin-specific-processing protease 48) (Deubiquitinating enzyme 48).

USP9X_MOUSE
θ value	1.53129e-07 (rank : 47)	NC score	0.594202 (rank : 58)
Query Neighborhood Hits	126	Target Neighborhood Hits	171	Shared Neighborhood Hits	74
SwissProt Accessions	P70398, Q62497	Gene names	Usp9x, Fafl, Fam
Domain Architecture
Description	Probable ubiquitin carboxyl-terminal hydrolase FAF-X (EC 3.1.2.15) (Ubiquitin thioesterase FAF-X) (Ubiquitin-specific-processing protease FAF-X) (Deubiquitinating enzyme FAF-X) (Fat facets protein-related, X- linked) (Ubiquitin-specific protease 9, X chromosome) (Ubiquitin carboxyl-terminal hydrolase FAM) (Fat facets homolog).

UBP24_HUMAN
θ value	5.81887e-07 (rank : 48)	NC score	0.665476 (rank : 46)
Query Neighborhood Hits	126	Target Neighborhood Hits	96	Shared Neighborhood Hits	71
SwissProt Accessions	Q9UPU5, Q6ZSY2, Q8N2Y4, Q9NXD1	Gene names	USP24, KIAA1057
Domain Architecture	No domain graphic available
Description	Ubiquitin carboxyl-terminal hydrolase 24 (EC 3.1.2.15) (Ubiquitin thioesterase 24) (Ubiquitin-specific-processing protease 24) (Deubiquitinating enzyme 24).

UBP30_HUMAN
θ value	1.69304e-06 (rank : 49)	NC score	0.721366 (rank : 41)
Query Neighborhood Hits	126	Target Neighborhood Hits	94	Shared Neighborhood Hits	70
SwissProt Accessions	Q70CQ3, Q8WTU7, Q96JX4, Q9BSS3	Gene names	USP30
Domain Architecture	No domain graphic available
Description	Ubiquitin carboxyl-terminal hydrolase 30 (EC 3.1.2.15) (Ubiquitin thioesterase 30) (Ubiquitin-specific-processing protease 30) (Deubiquitinating enzyme 30).

UBP48_MOUSE
θ value	1.69304e-06 (rank : 50)	NC score	0.722098 (rank : 40)
Query Neighborhood Hits	126	Target Neighborhood Hits	124	Shared Neighborhood Hits	75
SwissProt Accessions	Q3V0C5, Q3TM39, Q571J9, Q8VDJ1	Gene names	Usp48, Kiaa4202
Domain Architecture	No domain graphic available
Description	Ubiquitin carboxyl-terminal hydrolase 48 (EC 3.1.2.15) (Ubiquitin thioesterase 48) (Ubiquitin-specific-processing protease 48) (Deubiquitinating enzyme 48).

USP9Y_HUMAN
θ value	3.77169e-06 (rank : 51)	NC score	0.591604 (rank : 59)
Query Neighborhood Hits	126	Target Neighborhood Hits	109	Shared Neighborhood Hits	74
SwissProt Accessions	O00507, O14601	Gene names	USP9Y, DFFRY, USP10
Domain Architecture
Description	Probable ubiquitin carboxyl-terminal hydrolase FAF-Y (EC 3.1.2.15) (Ubiquitin thioesterase FAF-Y) (Ubiquitin-specific-processing protease FAF-Y) (Deubiquitinating enzyme FAF-Y) (Fat facets protein-related, Y- linked) (Ubiquitin-specific protease 9, Y chromosome).

UBP18_MOUSE
θ value	4.92598e-06 (rank : 52)	NC score	0.727967 (rank : 38)
Query Neighborhood Hits	126	Target Neighborhood Hits	77	Shared Neighborhood Hits	69
SwissProt Accessions	Q9WTV6	Gene names	Usp18, Ubp43
Domain Architecture
Description	Ubl carboxyl-terminal hydrolase 18 (EC 3.1.2.-) (Ubl thioesterase 18) (ISG15-specific-processing protease) (43 kDa ISG15-specific protease).

UBP10_MOUSE
θ value	1.43324e-05 (rank : 53)	NC score	0.663391 (rank : 47)
Query Neighborhood Hits	126	Target Neighborhood Hits	150	Shared Neighborhood Hits	69
SwissProt Accessions	P52479, Q91VY7	Gene names	Usp10, Ode-1, Uchrp
Domain Architecture
Description	Ubiquitin carboxyl-terminal hydrolase 10 (EC 3.1.2.15) (Ubiquitin thioesterase 10) (Ubiquitin-specific-processing protease 10) (Deubiquitinating enzyme 10).

UBP10_HUMAN
θ value	1.87187e-05 (rank : 54)	NC score	0.656830 (rank : 49)
Query Neighborhood Hits	126	Target Neighborhood Hits	153	Shared Neighborhood Hits	70
SwissProt Accessions	Q14694, Q9BWG7, Q9NSL7	Gene names	USP10, KIAA0190
Domain Architecture
Description	Ubiquitin carboxyl-terminal hydrolase 10 (EC 3.1.2.15) (Ubiquitin thioesterase 10) (Ubiquitin-specific-processing protease 10) (Deubiquitinating enzyme 10).

UBP14_HUMAN
θ value	0.00020696 (rank : 55)	NC score	0.613969 (rank : 54)
Query Neighborhood Hits	126	Target Neighborhood Hits	89	Shared Neighborhood Hits	71
SwissProt Accessions	P54578	Gene names	USP14, TGT
Domain Architecture
Description	Ubiquitin carboxyl-terminal hydrolase 14 (EC 3.1.2.15) (Ubiquitin thioesterase 14) (Ubiquitin-specific-processing protease 14) (Deubiquitinating enzyme 14).

UBP25_HUMAN
θ value	0.000270298 (rank : 56)	NC score	0.408513 (rank : 73)
Query Neighborhood Hits	126	Target Neighborhood Hits	124	Shared Neighborhood Hits	72
SwissProt Accessions	Q9UHP3, Q9H9W1	Gene names	USP25, USP21
Domain Architecture
Description	Ubiquitin carboxyl-terminal hydrolase 25 (EC 3.1.2.15) (Ubiquitin thioesterase 25) (Ubiquitin-specific-processing protease 25) (Deubiquitinating enzyme 25) (USP on chromosome 21).

UBP25_MOUSE
θ value	0.00035302 (rank : 57)	NC score	0.410105 (rank : 72)
Query Neighborhood Hits	126	Target Neighborhood Hits	116	Shared Neighborhood Hits	72
SwissProt Accessions	P57080, Q80ZT9	Gene names	Usp25
Domain Architecture
Description	Ubiquitin carboxyl-terminal hydrolase 25 (EC 3.1.2.15) (Ubiquitin thioesterase 25) (Ubiquitin-specific-processing protease 25) (Deubiquitinating enzyme 25) (mUSP25).

UBP40_HUMAN
θ value	0.00035302 (rank : 58)	NC score	0.657566 (rank : 48)
Query Neighborhood Hits	126	Target Neighborhood Hits	81	Shared Neighborhood Hits	71
SwissProt Accessions	Q9NVE5, Q6NX38, Q70EL0	Gene names	USP40
Domain Architecture	No domain graphic available
Description	Ubiquitin carboxyl-terminal hydrolase 40 (EC 3.1.2.15) (Ubiquitin thioesterase 40) (Ubiquitin-specific-processing protease 40) (Deubiquitinating enzyme 40).

UBP28_HUMAN
θ value	0.000602161 (rank : 59)	NC score	0.427812 (rank : 70)
Query Neighborhood Hits	126	Target Neighborhood Hits	117	Shared Neighborhood Hits	74
SwissProt Accessions	Q96RU2, Q9P213	Gene names	USP28, KIAA1515
Domain Architecture
Description	Ubiquitin carboxyl-terminal hydrolase 28 (EC 3.1.2.15) (Ubiquitin thioesterase 28) (Ubiquitin-specific-processing protease 28) (Deubiquitinating enzyme 28).

UBP28_MOUSE
θ value	0.000602161 (rank : 60)	NC score	0.422964 (rank : 71)
Query Neighborhood Hits	126	Target Neighborhood Hits	178	Shared Neighborhood Hits	73
SwissProt Accessions	Q5I043, Q6NZP3, Q6ZPP1, Q8BWI1	Gene names	Usp28, Kiaa1515
Domain Architecture	No domain graphic available
Description	Ubiquitin carboxyl-terminal hydrolase 28 (EC 3.1.2.15) (Ubiquitin thioesterase 28) (Ubiquitin-specific-processing protease 28) (Deubiquitinating enzyme 28).

UBP29_HUMAN
θ value	0.000786445 (rank : 61)	NC score	0.551613 (rank : 63)
Query Neighborhood Hits	126	Target Neighborhood Hits	94	Shared Neighborhood Hits	71
SwissProt Accessions	Q9HBJ7	Gene names	USP29
Domain Architecture
Description	Ubiquitin carboxyl-terminal hydrolase 29 (EC 3.1.2.15) (Ubiquitin thioesterase 29) (Ubiquitin-specific-processing protease 29) (Deubiquitinating enzyme 29).

UBP7_HUMAN
θ value	0.000786445 (rank : 62)	NC score	0.655479 (rank : 50)
Query Neighborhood Hits	126	Target Neighborhood Hits	93	Shared Neighborhood Hits	70
SwissProt Accessions	Q93009	Gene names	USP7, HAUSP
Domain Architecture
Description	Ubiquitin carboxyl-terminal hydrolase 7 (EC 3.1.2.15) (Ubiquitin thioesterase 7) (Ubiquitin-specific-processing protease 7) (Deubiquitinating enzyme 7) (Herpesvirus-associated ubiquitin-specific protease).

UBP14_MOUSE
θ value	0.00102713 (rank : 63)	NC score	0.597521 (rank : 55)
Query Neighborhood Hits	126	Target Neighborhood Hits	87	Shared Neighborhood Hits	70
SwissProt Accessions	Q9JMA1, Q543U5, Q923F2, Q9D0L0	Gene names	Usp14
Domain Architecture
Description	Ubiquitin carboxyl-terminal hydrolase 14 (EC 3.1.2.15) (Ubiquitin thioesterase 14) (Ubiquitin-specific-processing protease 14) (Deubiquitinating enzyme 14).

UBP47_MOUSE
θ value	0.00102713 (rank : 64)	NC score	0.632051 (rank : 52)
Query Neighborhood Hits	126	Target Neighborhood Hits	135	Shared Neighborhood Hits	71
SwissProt Accessions	Q8BY87, Q5EBP2, Q6KAR9, Q80V06, Q8BHU1, Q8BI15, Q8BI16, Q8BUW4, Q91X25	Gene names	Usp47
Domain Architecture	No domain graphic available
Description	Ubiquitin carboxyl-terminal hydrolase 47 (EC 3.1.2.15) (Ubiquitin thioesterase 47) (Ubiquitin-specific-processing protease 47) (Deubiquitinating enzyme 47).

UBP26_HUMAN
θ value	0.00175202 (rank : 65)	NC score	0.537054 (rank : 64)
Query Neighborhood Hits	126	Target Neighborhood Hits	108	Shared Neighborhood Hits	71
SwissProt Accessions	Q9BXU7	Gene names	USP26
Domain Architecture
Description	Ubiquitin carboxyl-terminal hydrolase 26 (EC 3.1.2.15) (Ubiquitin thioesterase 26) (Ubiquitin-specific-processing protease 26) (Deubiquitinating enzyme 26).

UBP47_HUMAN
θ value	0.00175202 (rank : 66)	NC score	0.627468 (rank : 53)
Query Neighborhood Hits	126	Target Neighborhood Hits	149	Shared Neighborhood Hits	73
SwissProt Accessions	Q96K76, Q658U0, Q86Y73, Q8TEP6, Q9BWI0, Q9NWN1	Gene names	USP47
Domain Architecture	No domain graphic available
Description	Ubiquitin carboxyl-terminal hydrolase 47 (EC 3.1.2.15) (Ubiquitin thioesterase 47) (Ubiquitin-specific-processing protease 47) (Deubiquitinating enzyme 47).

UBP34_HUMAN
θ value	0.00509761 (rank : 67)	NC score	0.577032 (rank : 62)
Query Neighborhood Hits	126	Target Neighborhood Hits	210	Shared Neighborhood Hits	70
SwissProt Accessions	Q70CQ2, O60316, O94834, Q3B777, Q6P6C9, Q7L8P6, Q8N3T9, Q8TBW2, Q9UGA1	Gene names	USP34, KIAA0570, KIAA0729
Domain Architecture	No domain graphic available
Description	Ubiquitin carboxyl-terminal hydrolase 34 (EC 3.1.2.15) (Ubiquitin thioesterase 34) (Ubiquitin-specific-processing protease 34) (Deubiquitinating enzyme 34).

UBP34_MOUSE
θ value	0.00665767 (rank : 68)	NC score	0.577190 (rank : 61)
Query Neighborhood Hits	126	Target Neighborhood Hits	189	Shared Neighborhood Hits	71
SwissProt Accessions	Q6ZQ93, Q3UPN0, Q6P563, Q7TMJ6, Q8CCH0	Gene names	Usp34, Kiaa0570
Domain Architecture	No domain graphic available
Description	Ubiquitin carboxyl-terminal hydrolase 34 (EC 3.1.2.15) (Ubiquitin thioesterase 34) (Ubiquitin-specific-processing protease 34) (Deubiquitinating enzyme 34).

HDAC6_HUMAN
θ value	0.0113563 (rank : 69)	NC score	0.131199 (rank : 77)
Query Neighborhood Hits	126	Target Neighborhood Hits	145	Shared Neighborhood Hits	19
SwissProt Accessions	Q9UBN7	Gene names	HDAC6
Domain Architecture
Description	Histone deacetylase 6 (HD6).

HDAC6_MOUSE
θ value	0.0113563 (rank : 70)	NC score	0.138528 (rank : 76)
Query Neighborhood Hits	126	Target Neighborhood Hits	88	Shared Neighborhood Hits	17
SwissProt Accessions	Q9Z2V5	Gene names	Hdac6
Domain Architecture
Description	Histone deacetylase 6 (HD6) (Histone deacetylase mHDA2).

SNUT2_HUMAN
θ value	0.0113563 (rank : 71)	NC score	0.586553 (rank : 60)
Query Neighborhood Hits	126	Target Neighborhood Hits	79	Shared Neighborhood Hits	61
SwissProt Accessions	Q53GS9, Q6NX47, Q96RK9, Q9BV89, Q9H381, Q9P050, Q9Y310	Gene names	USP39
Domain Architecture	No domain graphic available
Description	U4/U6.U5 tri-snRNP-associated protein 2 (U4/U6.U5 tri-snRNP-associated 65 kDa protein) (65K) (Inactive ubiquitin-specific peptidase 39) (SAD1 homolog).

SNUT2_MOUSE
θ value	0.0113563 (rank : 72)	NC score	0.597035 (rank : 56)
Query Neighborhood Hits	126	Target Neighborhood Hits	80	Shared Neighborhood Hits	62
SwissProt Accessions	Q3TIX9, Q3TI55, Q8BLI5, Q8BZZ5, Q9CQR1	Gene names	Usp39
Domain Architecture	No domain graphic available
Description	U4/U6.U5 tri-snRNP-associated protein 2 (Inactive ubiquitin-specific peptidase 39).

UBP29_MOUSE
θ value	0.0193708 (rank : 73)	NC score	0.523597 (rank : 65)
Query Neighborhood Hits	126	Target Neighborhood Hits	95	Shared Neighborhood Hits	72
SwissProt Accessions	Q9ES63	Gene names	Usp29
Domain Architecture
Description	Ubiquitin carboxyl-terminal hydrolase 29 (EC 3.1.2.15) (Ubiquitin thioesterase 29) (Ubiquitin-specific-processing protease 29) (Deubiquitinating enzyme 29).

CCD21_MOUSE
θ value	0.0330416 (rank : 74)	NC score	0.044111 (rank : 83)
Query Neighborhood Hits	126	Target Neighborhood Hits	1135	Shared Neighborhood Hits	30
SwissProt Accessions	Q8BMK0, Q8BUF1, Q8K0E6	Gene names	Ccdc21
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 21.

UBP13_HUMAN
θ value	0.0330416 (rank : 75)	NC score	0.476034 (rank : 66)
Query Neighborhood Hits	126	Target Neighborhood Hits	99	Shared Neighborhood Hits	76
SwissProt Accessions	Q92995	Gene names	USP13, ISOT3
Domain Architecture
Description	Ubiquitin carboxyl-terminal hydrolase 13 (EC 3.1.2.15) (Ubiquitin thioesterase 13) (Ubiquitin-specific-processing protease 13) (Deubiquitinating enzyme 13) (Isopeptidase T-3) (ISOT-3).

REST_HUMAN
θ value	0.0431538 (rank : 76)	NC score	0.027381 (rank : 92)
Query Neighborhood Hits	126	Target Neighborhood Hits	1605	Shared Neighborhood Hits	34
SwissProt Accessions	P30622	Gene names	RSN, CYLN1
Domain Architecture
Description	Restin (Cytoplasmic linker protein 170 alpha-2) (CLIP-170) (Reed- Sternberg intermediate filament-associated protein) (Cytoplasmic linker protein 1).

CCD21_HUMAN
θ value	0.0563607 (rank : 77)	NC score	0.042928 (rank : 84)
Query Neighborhood Hits	126	Target Neighborhood Hits	1228	Shared Neighborhood Hits	35
SwissProt Accessions	Q6P2H3, Q5VY68, Q5VY70, Q9H6Q1, Q9H828, Q9UF52	Gene names	CCDC21
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 21.

CCD46_MOUSE
θ value	0.0961366 (rank : 78)	NC score	0.033407 (rank : 87)
Query Neighborhood Hits	126	Target Neighborhood Hits	1405	Shared Neighborhood Hits	32
SwissProt Accessions	Q5PR68, Q80ZN6, Q99JS4, Q9D9T1	Gene names	Ccdc46
Domain Architecture	No domain graphic available
Description	Coiled coil domain-containing protein 46.

UACA_HUMAN
θ value	0.125558 (rank : 79)	NC score	0.022882 (rank : 102)
Query Neighborhood Hits	126	Target Neighborhood Hits	1622	Shared Neighborhood Hits	26
SwissProt Accessions	Q9BZF9, Q8N3B8, Q9HCL1, Q9NWC6	Gene names	UACA, KIAA1561
Domain Architecture	No domain graphic available
Description	Uveal autoantigen with coiled-coil domains and ankyrin repeats protein.

NEB1_HUMAN
θ value	0.163984 (rank : 80)	NC score	0.034036 (rank : 86)
Query Neighborhood Hits	126	Target Neighborhood Hits	829	Shared Neighborhood Hits	29
SwissProt Accessions	Q9ULJ8, O76059, Q9NXT2	Gene names	PPP1R9A, KIAA1222
Domain Architecture	No domain graphic available
Description	Neurabin-1 (Neurabin-I) (Neural tissue-specific F-actin-binding protein I) (Protein phosphatase 1 regulatory subunit 9A).

ITPR2_HUMAN
θ value	0.279714 (rank : 81)	NC score	0.018489 (rank : 112)
Query Neighborhood Hits	126	Target Neighborhood Hits	74	Shared Neighborhood Hits	4
SwissProt Accessions	Q14571, O94773	Gene names	ITPR2
Domain Architecture
Description	Inositol 1,4,5-trisphosphate receptor type 2 (Type 2 inositol 1,4,5- trisphosphate receptor) (Type 2 InsP3 receptor) (IP3 receptor isoform 2) (InsP3R2).

NOL8_HUMAN
θ value	0.279714 (rank : 82)	NC score	0.039401 (rank : 85)
Query Neighborhood Hits	126	Target Neighborhood Hits	297	Shared Neighborhood Hits	8
SwissProt Accessions	Q76FK4, Q5TCC7, Q5TCC8, Q5TCD3, Q5TCD5, Q5TCD6, Q5TCD7, Q76D35, Q7L3E2, Q9H586, Q9H795, Q9H7W7, Q9H9J6, Q9NWA4, Q9NWM4	Gene names	NOL8, NOP132
Domain Architecture	No domain graphic available
Description	Nucleolar protein 8 (Nucleolar protein Nop132).

UBP26_MOUSE
θ value	0.279714 (rank : 83)	NC score	0.435478 (rank : 69)
Query Neighborhood Hits	126	Target Neighborhood Hits	107	Shared Neighborhood Hits	70
SwissProt Accessions	Q99MX1	Gene names	Usp26
Domain Architecture
Description	Ubiquitin carboxyl-terminal hydrolase 26 (EC 3.1.2.15) (Ubiquitin thioesterase 26) (Ubiquitin-specific-processing protease 26) (Deubiquitinating enzyme 26).

UBP5_HUMAN
θ value	0.279714 (rank : 84)	NC score	0.474273 (rank : 67)
Query Neighborhood Hits	126	Target Neighborhood Hits	109	Shared Neighborhood Hits	76
SwissProt Accessions	P45974, Q96J22	Gene names	USP5, ISOT
Domain Architecture
Description	Ubiquitin carboxyl-terminal hydrolase 5 (EC 3.1.2.15) (Ubiquitin thioesterase 5) (Ubiquitin-specific-processing protease 5) (Deubiquitinating enzyme 5) (Isopeptidase T).

UBP5_MOUSE
θ value	0.279714 (rank : 85)	NC score	0.470424 (rank : 68)
Query Neighborhood Hits	126	Target Neighborhood Hits	106	Shared Neighborhood Hits	76
SwissProt Accessions	P56399	Gene names	Usp5, Isot
Domain Architecture
Description	Ubiquitin carboxyl-terminal hydrolase 5 (EC 3.1.2.15) (Ubiquitin thioesterase 5) (Ubiquitin-specific-processing protease 5) (Deubiquitinating enzyme 5) (Isopeptidase T).

JPH1_MOUSE
θ value	0.365318 (rank : 86)	NC score	0.018983 (rank : 111)
Query Neighborhood Hits	126	Target Neighborhood Hits	120	Shared Neighborhood Hits	3
SwissProt Accessions	Q9ET80, Q9EQZ3	Gene names	Jph1, Jp1
Domain Architecture
Description	Junctophilin-1 (Junctophilin type 1) (JP-1).

MYH11_HUMAN
θ value	0.365318 (rank : 87)	NC score	0.021430 (rank : 106)
Query Neighborhood Hits	126	Target Neighborhood Hits	1806	Shared Neighborhood Hits	31
SwissProt Accessions	P35749, O00396, O94944, P78422	Gene names	MYH11, KIAA0866
Domain Architecture
Description	Myosin-11 (Myosin heavy chain, smooth muscle isoform) (SMMHC).

MYH11_MOUSE
θ value	0.365318 (rank : 88)	NC score	0.022322 (rank : 103)
Query Neighborhood Hits	126	Target Neighborhood Hits	1777	Shared Neighborhood Hits	34
SwissProt Accessions	O08638, O08639, Q62462, Q64195	Gene names	Myh11
Domain Architecture
Description	Myosin-11 (Myosin heavy chain, smooth muscle isoform) (SMMHC).

RTN4_MOUSE
θ value	0.365318 (rank : 89)	NC score	0.029396 (rank : 89)
Query Neighborhood Hits	126	Target Neighborhood Hits	341	Shared Neighborhood Hits	9
SwissProt Accessions	Q99P72, Q5DTK9, Q7TNB7, Q80W95, Q8BGK7, Q8BGM9, Q8K290, Q8K3G8, Q9CTE3	Gene names	Rtn4, Kiaa0886, Nogo
Domain Architecture
Description	Reticulon-4 (Neurite outgrowth inhibitor) (Nogo protein).

CCD41_MOUSE
θ value	0.47712 (rank : 90)	NC score	0.025774 (rank : 95)
Query Neighborhood Hits	126	Target Neighborhood Hits	1399	Shared Neighborhood Hits	30
SwissProt Accessions	Q9D5R3, Q3U7X7, Q3UX57, Q80VF0	Gene names	Ccdc41
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 41.

MINT_HUMAN
θ value	0.47712 (rank : 91)	NC score	0.025083 (rank : 96)
Query Neighborhood Hits	126	Target Neighborhood Hits	1291	Shared Neighborhood Hits	27
SwissProt Accessions	Q96T58, Q9H9A8, Q9NWH5, Q9UQ01, Q9Y556	Gene names	SPEN, KIAA0929, MINT, SHARP
Domain Architecture
Description	Msx2-interacting protein (SPEN homolog) (SMART/HDAC1-associated repressor protein).

RAI14_MOUSE
θ value	0.47712 (rank : 92)	NC score	0.017776 (rank : 115)
Query Neighborhood Hits	126	Target Neighborhood Hits	1505	Shared Neighborhood Hits	27
SwissProt Accessions	Q9EP71, Q3URT3, Q6ZPT6	Gene names	Rai14, Kiaa1334, Norpeg
Domain Architecture	No domain graphic available
Description	Ankycorbin (Ankyrin repeat and coiled-coil structure-containing protein) (Retinoic acid-induced protein 14) (Novel retinal pigment epithelial cell protein) (p125).

ZCHC6_HUMAN
θ value	0.47712 (rank : 93)	NC score	0.025792 (rank : 94)
Query Neighborhood Hits	126	Target Neighborhood Hits	142	Shared Neighborhood Hits	7
SwissProt Accessions	Q5VYS8, Q5H9T0, Q5VYS5, Q5VYS7, Q658Z9, Q659A2, Q6MZJ3, Q8N5F0, Q96N57, Q96NE8, Q9C0F2, Q9H8M6	Gene names	ZCCHC6, KIAA1711
Domain Architecture	No domain graphic available
Description	Zinc finger CCHC domain-containing protein 6.

CN145_HUMAN
θ value	0.62314 (rank : 94)	NC score	0.028823 (rank : 90)
Query Neighborhood Hits	126	Target Neighborhood Hits	1196	Shared Neighborhood Hits	27
SwissProt Accessions	Q6ZU80, Q96ML4	Gene names	C14orf145
Domain Architecture	No domain graphic available
Description	Protein C14orf145.

CO3_HUMAN
θ value	0.62314 (rank : 95)	NC score	0.016691 (rank : 119)
Query Neighborhood Hits	126	Target Neighborhood Hits	36	Shared Neighborhood Hits	3
SwissProt Accessions	P01024	Gene names	C3
Domain Architecture
Description	Complement C3 precursor [Contains: Complement C3 beta chain; Complement C3 alpha chain; C3a anaphylatoxin; Complement C3b alpha' chain; Complement C3c fragment; Complement C3dg fragment; Complement C3g fragment; Complement C3d fragment; Complement C3f fragment].

SMC2_HUMAN
θ value	0.62314 (rank : 96)	NC score	0.024742 (rank : 97)
Query Neighborhood Hits	126	Target Neighborhood Hits	1405	Shared Neighborhood Hits	33
SwissProt Accessions	O95347, Q9P1P2	Gene names	SMC2L1, CAPE, SMC2
Domain Architecture
Description	Structural maintenance of chromosome 2-like 1 protein (Chromosome- associated protein E) (hCAP-E) (XCAP-E homolog).

CCD46_HUMAN
θ value	1.06291 (rank : 97)	NC score	0.028673 (rank : 91)
Query Neighborhood Hits	126	Target Neighborhood Hits	1430	Shared Neighborhood Hits	28
SwissProt Accessions	Q8N8E3, Q6PIB5, Q8NCR4, Q8NFR4	Gene names	CCDC46
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 46.

RIOK1_HUMAN
θ value	1.06291 (rank : 98)	NC score	0.029800 (rank : 88)
Query Neighborhood Hits	126	Target Neighborhood Hits	86	Shared Neighborhood Hits	4
SwissProt Accessions	Q9BRS2, Q8NDC8, Q96NV9	Gene names	RIOK1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase RIO1 (EC 2.7.11.1) (RIO kinase 1).

GAS8_HUMAN
θ value	1.38821 (rank : 99)	NC score	0.025843 (rank : 93)
Query Neighborhood Hits	126	Target Neighborhood Hits	819	Shared Neighborhood Hits	25
SwissProt Accessions	O95995	Gene names	GAS8, GAS11
Domain Architecture	No domain graphic available
Description	Growth-arrest-specific protein 8 (Growth arrest-specific 11).

STX7_MOUSE
θ value	1.81305 (rank : 100)	NC score	0.017574 (rank : 117)
Query Neighborhood Hits	126	Target Neighborhood Hits	131	Shared Neighborhood Hits	10
SwissProt Accessions	O70439	Gene names	Stx7, Syn7
Domain Architecture
Description	Syntaxin-7.

SEC63_HUMAN
θ value	2.36792 (rank : 101)	NC score	0.024704 (rank : 98)
Query Neighborhood Hits	126	Target Neighborhood Hits	586	Shared Neighborhood Hits	13
SwissProt Accessions	Q9UGP8, O95380, Q86VS9, Q8IWL0, Q9NTE0	Gene names	SEC63, SEC63L
Domain Architecture
Description	Translocation protein SEC63 homolog.

UBA3_HUMAN
θ value	2.36792 (rank : 102)	NC score	0.024124 (rank : 99)
Query Neighborhood Hits	126	Target Neighborhood Hits	22	Shared Neighborhood Hits	3
SwissProt Accessions	Q8TBC4, O76088, Q9NTU3	Gene names	UBE1C, UBA3
Domain Architecture	No domain graphic available
Description	NEDD8-activating enzyme E1 catalytic subunit (EC 6.3.2.-) (Ubiquitin- activating enzyme 3) (NEDD8-activating enzyme E1C) (Ubiquitin- activating enzyme E1C).

UBA3_MOUSE
θ value	2.36792 (rank : 103)	NC score	0.024107 (rank : 100)
Query Neighborhood Hits	126	Target Neighborhood Hits	22	Shared Neighborhood Hits	3
SwissProt Accessions	Q8C878, O88598, Q9D6B7	Gene names	Ube1c, Uba3
Domain Architecture	No domain graphic available
Description	NEDD8-activating enzyme E1 catalytic subunit (EC 6.3.2.-) (Ubiquitin- activating enzyme 3) (NEDD8-activating enzyme E1C) (Ubiquitin- activating enzyme E1C).

CENPC_HUMAN
θ value	3.0926 (rank : 104)	NC score	0.017577 (rank : 116)
Query Neighborhood Hits	126	Target Neighborhood Hits	147	Shared Neighborhood Hits	4
SwissProt Accessions	Q03188, Q9P0M5	Gene names	CENPC1, CENPC, ICEN7
Domain Architecture	No domain graphic available
Description	Centromere protein C 1 (CENP-C) (Centromere autoantigen C) (Interphase centromere complex protein 7).

EPIPL_MOUSE
θ value	3.0926 (rank : 105)	NC score	0.011737 (rank : 121)
Query Neighborhood Hits	126	Target Neighborhood Hits	118	Shared Neighborhood Hits	3
SwissProt Accessions	Q8R0W0	Gene names	Eppk1
Domain Architecture
Description	Epiplakin.

PLCB3_MOUSE
θ value	3.0926 (rank : 106)	NC score	0.019325 (rank : 108)
Query Neighborhood Hits	126	Target Neighborhood Hits	344	Shared Neighborhood Hits	21
SwissProt Accessions	P51432	Gene names	Plcb3
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta 3 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (Phospholipase C- beta-3) (PLC-beta-3).

MY18A_HUMAN
θ value	4.03905 (rank : 107)	NC score	0.017820 (rank : 114)
Query Neighborhood Hits	126	Target Neighborhood Hits	1929	Shared Neighborhood Hits	31
SwissProt Accessions	Q92614, Q8IXP8	Gene names	MYO18A, KIAA0216, MYSPDZ
Domain Architecture
Description	Myosin-18A (Myosin XVIIIa) (Myosin containing PDZ domain) (Molecule associated with JAK3 N-terminus) (MAJN).

SEC63_MOUSE
θ value	4.03905 (rank : 108)	NC score	0.021518 (rank : 105)
Query Neighborhood Hits	126	Target Neighborhood Hits	601	Shared Neighborhood Hits	15
SwissProt Accessions	Q8VHE0, Q8VEB9	Gene names	Sec63, Sec63l
Domain Architecture
Description	Translocation protein SEC63 homolog.

2A5G_MOUSE
θ value	5.27518 (rank : 109)	NC score	0.007311 (rank : 124)
Query Neighborhood Hits	126	Target Neighborhood Hits	25	Shared Neighborhood Hits	2
SwissProt Accessions	Q60996, O35708, Q99KW8, Q99N67, Q99N68	Gene names	Ppp2r5c
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform (PP2A, B subunit, B' gamma isoform) (PP2A, B subunit, B56 gamma isoform) (PP2A, B subunit, PR61 gamma isoform) (PP2A, B subunit, R5 gamma isoform) (PP2A, B subunit, B'alpha3 isoform).

ANR26_HUMAN
θ value	5.27518 (rank : 110)	NC score	0.017358 (rank : 118)
Query Neighborhood Hits	126	Target Neighborhood Hits	1614	Shared Neighborhood Hits	28
SwissProt Accessions	Q9UPS8, Q2TAZ3, Q6ZR14, Q9H1Q1, Q9NSK9, Q9NTD5, Q9NW69	Gene names	ANKRD26, KIAA1074
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 26.

GOGA3_MOUSE
θ value	5.27518 (rank : 111)	NC score	0.018212 (rank : 113)
Query Neighborhood Hits	126	Target Neighborhood Hits	1437	Shared Neighborhood Hits	26
SwissProt Accessions	P55937, Q80VF5, Q8CCK4, Q9QYT2, Q9QYT3	Gene names	Golga3, Mea2
Domain Architecture
Description	Golgin subfamily A member 3 (Golgin-160) (Male-enhanced antigen 2) (MEA-2).

NUAK1_MOUSE
θ value	5.27518 (rank : 112)	NC score	-0.006541 (rank : 130)
Query Neighborhood Hits	126	Target Neighborhood Hits	881	Shared Neighborhood Hits	5
SwissProt Accessions	Q641K5, Q6I6D6, Q8CGE1	Gene names	Nuak1, Kiaa0537
Domain Architecture	No domain graphic available
Description	NUAK family SNF1-like kinase 1 (EC 2.7.11.1).

ASPD_MOUSE
θ value	6.88961 (rank : 113)	NC score	0.019143 (rank : 110)
Query Neighborhood Hits	126	Target Neighborhood Hits	4	Shared Neighborhood Hits	2
SwissProt Accessions	Q9DCQ2, Q8VCQ0	Gene names
Domain Architecture	No domain graphic available
Description	Putative L-aspartate dehydrogenase (EC 1.4.1.21).

JADE3_HUMAN
θ value	6.88961 (rank : 114)	NC score	0.004727 (rank : 128)
Query Neighborhood Hits	126	Target Neighborhood Hits	148	Shared Neighborhood Hits	4
SwissProt Accessions	Q92613, Q6IE79	Gene names	PHF16, JADE3, KIAA0215
Domain Architecture
Description	Protein Jade-3 (PHD finger protein 16).

RAD50_MOUSE
θ value	6.88961 (rank : 115)	NC score	0.019188 (rank : 109)
Query Neighborhood Hits	126	Target Neighborhood Hits	1366	Shared Neighborhood Hits	30
SwissProt Accessions	P70388, Q6PEB0, Q8C2T7, Q9CU59	Gene names	Rad50
Domain Architecture	No domain graphic available
Description	DNA repair protein RAD50 (EC 3.6.-.-) (mRad50).

TRIPB_HUMAN
θ value	6.88961 (rank : 116)	NC score	0.020166 (rank : 107)
Query Neighborhood Hits	126	Target Neighborhood Hits	1587	Shared Neighborhood Hits	31
SwissProt Accessions	Q15643, O14689, O15154, O95949	Gene names	TRIP11, CEV14
Domain Architecture	No domain graphic available
Description	Thyroid receptor-interacting protein 11 (TRIP-11) (Golgi-associated microtubule-binding protein 210) (GMAP-210) (Trip230) (Clonal evolution-related gene on chromosome 14).

ZN224_HUMAN
θ value	6.88961 (rank : 117)	NC score	-0.006677 (rank : 131)
Query Neighborhood Hits	126	Target Neighborhood Hits	808	Shared Neighborhood Hits	2
SwissProt Accessions	Q9NZL3, Q86V10, Q8IZC8, Q9UID9, Q9Y2P6	Gene names	ZNF224, BMZF2, ZNF255
Domain Architecture
Description	Zinc finger protein 224 (Zinc finger protein 255) (Bone marrow zinc finger 2) (BMZF-2).

ACOX1_MOUSE
θ value	8.99809 (rank : 118)	NC score	0.005901 (rank : 127)
Query Neighborhood Hits	126	Target Neighborhood Hits	27	Shared Neighborhood Hits	2
SwissProt Accessions	Q9R0H0, O35616, Q3TDG0	Gene names	Acox1, Acox, Paox
Domain Architecture
Description	Acyl-coenzyme A oxidase 1, peroxisomal (EC 1.3.3.6) (Palmitoyl-CoA oxidase) (AOX).

CAC1A_HUMAN
θ value	8.99809 (rank : 119)	NC score	0.000975 (rank : 129)
Query Neighborhood Hits	126	Target Neighborhood Hits	387	Shared Neighborhood Hits	2
SwissProt Accessions	O00555, P78510, P78511, Q16290, Q92690, Q99790, Q99791, Q99792, Q99793	Gene names	CACNA1A, CACH4, CACN3, CACNL1A4
Domain Architecture
Description	Voltage-dependent P/Q-type calcium channel subunit alpha-1A (Voltage- gated calcium channel subunit alpha Cav2.1) (Calcium channel, L type, alpha-1 polypeptide isoform 4) (Brain calcium channel I) (BI).

CCD96_MOUSE
θ value	8.99809 (rank : 120)	NC score	0.021844 (rank : 104)
Query Neighborhood Hits	126	Target Neighborhood Hits	704	Shared Neighborhood Hits	28
SwissProt Accessions	Q9CR92	Gene names	Ccdc96
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 96.

CI039_HUMAN
θ value	8.99809 (rank : 121)	NC score	0.023899 (rank : 101)
Query Neighborhood Hits	126	Target Neighborhood Hits	1171	Shared Neighborhood Hits	31
SwissProt Accessions	Q9NXG0, Q5VYJ0, Q9HAJ5	Gene names	C9orf39
Domain Architecture	No domain graphic available
Description	Protein C9orf39.

JHD1B_HUMAN
θ value	8.99809 (rank : 122)	NC score	0.006159 (rank : 125)
Query Neighborhood Hits	126	Target Neighborhood Hits	178	Shared Neighborhood Hits	4
SwissProt Accessions	Q8NHM5, Q8NCI2, Q96HC7, Q96SL0, Q96T03, Q9NS96, Q9UF75	Gene names	FBXL10, CXXC2, FBL10, JHDM1B, PCCX2
Domain Architecture	No domain graphic available
Description	JmjC domain-containing histone demethylation protein 1B (EC 1.14.11.-) (F-box/LRR-repeat protein 10) (F-box and leucine-rich repeat protein 10) (F-box protein FBL10) (Protein JEMMA) (Jumonji domain-containing EMSY-interactor methyltransferase motif protein) (CXXC-type zinc finger protein 2) (Protein-containing CXXC domain 2).

JHD1B_MOUSE
θ value	8.99809 (rank : 123)	NC score	0.006150 (rank : 126)
Query Neighborhood Hits	126	Target Neighborhood Hits	214	Shared Neighborhood Hits	6
SwissProt Accessions	Q6P1G2, Q3V396, Q6PFD0, Q6ZPE8, Q9CSF7, Q9QZN6	Gene names	Fbxl10, Fbl10, Jhdm1b, Kiaa3014
Domain Architecture	No domain graphic available
Description	JmjC domain-containing histone demethylation protein 1B (EC 1.14.11.-) (F-box/LRR-repeat protein 10) (F-box and leucine-rich repeat protein 10) (F-box protein FBL10).

LARP4_MOUSE
θ value	8.99809 (rank : 124)	NC score	0.007955 (rank : 123)
Query Neighborhood Hits	126	Target Neighborhood Hits	260	Shared Neighborhood Hits	4
SwissProt Accessions	Q8BWW4, Q3UR69	Gene names	Larp4
Domain Architecture	No domain graphic available
Description	La-related protein 4 (La ribonucleoprotein domain family member 4).

PARG_HUMAN
θ value	8.99809 (rank : 125)	NC score	0.012600 (rank : 120)
Query Neighborhood Hits	126	Target Neighborhood Hits	97	Shared Neighborhood Hits	5
SwissProt Accessions	Q86W56, Q6E4P6, Q6E4P7, Q7Z742, Q9Y4W7	Gene names	PARG
Domain Architecture	No domain graphic available
Description	Poly(ADP-ribose) glycohydrolase (EC 3.2.1.143).

TERF1_HUMAN
θ value	8.99809 (rank : 126)	NC score	0.009905 (rank : 122)
Query Neighborhood Hits	126	Target Neighborhood Hits	83	Shared Neighborhood Hits	5
SwissProt Accessions	P54274, Q15553, Q93029	Gene names	TERF1, PIN2, TRF, TRF1
Domain Architecture
Description	Telomeric repeat-binding factor 1 (TTAGGG repeat-binding factor 1) (NIMA-interacting protein 2) (Telomeric protein Pin2/TRF1).

GGNB1_HUMAN
θ value	θ > 10 (rank : 127)	NC score	0.084415 (rank : 79)
Query Neighborhood Hits	126	Target Neighborhood Hits	10	Shared Neighborhood Hits	5
SwissProt Accessions	Q5YKI7, Q5YKI8	Gene names	GGNBP1
Domain Architecture	No domain graphic available
Description	Gametogenetin-binding protein 1.

GGNB1_MOUSE
θ value	θ > 10 (rank : 128)	NC score	0.110995 (rank : 78)
Query Neighborhood Hits	126	Target Neighborhood Hits	23	Shared Neighborhood Hits	5
SwissProt Accessions	Q6K1E7, Q8C5T9	Gene names	Ggnbp1
Domain Architecture	No domain graphic available
Description	Gametogenetin-binding protein 1.

TBCD3_HUMAN
θ value	θ > 10 (rank : 129)	NC score	0.065221 (rank : 80)
Query Neighborhood Hits	126	Target Neighborhood Hits	51	Shared Neighborhood Hits	1
SwissProt Accessions	Q8IZP1, Q9H0B9, Q9UDD4	Gene names	TBC1D3, PRC17
Domain Architecture
Description	TBC1 domain family member 3 (Rab GTPase-activating protein PRC17) (Prostate cancer gene 17 protein) (TRE17 alpha protein).

UBP54_HUMAN
θ value	θ > 10 (rank : 130)	NC score	0.052727 (rank : 82)
Query Neighborhood Hits	126	Target Neighborhood Hits	21	Shared Neighborhood Hits	14
SwissProt Accessions	Q70EL1, Q5F2F4	Gene names	USP54, C10orf29
Domain Architecture	No domain graphic available
Description	Inactive ubiquitin carboxyl-terminal hydrolase 54 (Inactive ubiquitin- specific peptidase 54).

UBP54_MOUSE
θ value	θ > 10 (rank : 131)	NC score	0.053879 (rank : 81)
Query Neighborhood Hits	126	Target Neighborhood Hits	19	Shared Neighborhood Hits	13
SwissProt Accessions	Q8BL06, Q8BZ28	Gene names	Usp54
Domain Architecture	No domain graphic available
Description	Inactive ubiquitin carboxyl-terminal hydrolase 54 (Inactive ubiquitin- specific peptidase 54).

Hits sorted by NC score

UBP16_HUMAN
NC score	0.999962 (rank : 1)	θ value	0 (rank : 1)
Query Neighborhood Hits	126	Target Neighborhood Hits	126	Shared Neighborhood Hits	126
SwissProt Accessions	Q9Y5T5, Q8NEL3	Gene names	USP16
Domain Architecture
Description	Ubiquitin carboxyl-terminal hydrolase 16 (EC 3.1.2.15) (Ubiquitin thioesterase 16) (Ubiquitin-specific-processing protease 16) (Deubiquitinating enzyme 16) (Ubiquitin-processing protease UBP-M).

UBP3_MOUSE
NC score	0.872035 (rank : 2)	θ value	3.88503e-19 (rank : 5)
Query Neighborhood Hits	126	Target Neighborhood Hits	89	Shared Neighborhood Hits	77
SwissProt Accessions	Q91W36	Gene names	Usp3
Domain Architecture
Description	Ubiquitin carboxyl-terminal hydrolase 3 (EC 3.1.2.15) (Ubiquitin thioesterase 3) (Ubiquitin-specific-processing protease 3) (Deubiquitinating enzyme 3).

UBP3_HUMAN
NC score	0.863062 (rank : 3)	θ value	4.44505e-15 (rank : 22)
Query Neighborhood Hits	126	Target Neighborhood Hits	88	Shared Neighborhood Hits	77
SwissProt Accessions	Q9Y6I4	Gene names	USP3
Domain Architecture
Description	Ubiquitin carboxyl-terminal hydrolase 3 (EC 3.1.2.15) (Ubiquitin thioesterase 3) (Ubiquitin-specific-processing protease 3) (Deubiquitinating enzyme 3).

UBP2_MOUSE
NC score	0.860029 (rank : 4)	θ value	1.33526e-19 (rank : 4)
Query Neighborhood Hits	126	Target Neighborhood Hits	86	Shared Neighborhood Hits	73
SwissProt Accessions	O88623, Q6X4T9, Q6X4U1, Q8VD74, Q9JJ87	Gene names	Usp2, Ubp41
Domain Architecture
Description	Ubiquitin carboxyl-terminal hydrolase 2 (EC 3.1.2.15) (Ubiquitin thioesterase 2) (Ubiquitin-specific-processing protease 2) (Deubiquitinating enzyme 2) (41 kDa ubiquitin-specific protease).

UBP2_HUMAN
NC score	0.856254 (rank : 5)	θ value	1.63225e-17 (rank : 8)
Query Neighborhood Hits	126	Target Neighborhood Hits	84	Shared Neighborhood Hits	73
SwissProt Accessions	O75604, Q96MB9, Q9BQ21	Gene names	USP2, UBP41
Domain Architecture
Description	Ubiquitin carboxyl-terminal hydrolase 2 (EC 3.1.2.15) (Ubiquitin thioesterase 2) (Ubiquitin-specific-processing protease 2) (Deubiquitinating enzyme 2) (41 kDa ubiquitin-specific protease).

UBP50_MOUSE
NC score	0.849195 (rank : 6)	θ value	2.20605e-14 (rank : 24)
Query Neighborhood Hits	126	Target Neighborhood Hits	80	Shared Neighborhood Hits	73
SwissProt Accessions	Q6P8X6, Q9D558, Q9D9E7	Gene names	Usp50
Domain Architecture	No domain graphic available
Description	Putative ubiquitin carboxyl-terminal hydrolase 50 (EC 3.1.2.15) (Ubiquitin thioesterase 50) (Ubiquitin-specific-processing protease 50) (Deubiquitinating enzyme 50).

UBP22_HUMAN
NC score	0.847720 (rank : 7)	θ value	6.20254e-17 (rank : 12)
Query Neighborhood Hits	126	Target Neighborhood Hits	87	Shared Neighborhood Hits	77
SwissProt Accessions	Q9UPT9	Gene names	USP22, KIAA1063, USP3L
Domain Architecture	No domain graphic available
Description	Ubiquitin carboxyl-terminal hydrolase 22 (EC 3.1.2.15) (Ubiquitin thioesterase 22) (Ubiquitin-specific-processing protease 22) (Deubiquitinating enzyme 22).

UBP22_MOUSE
NC score	0.845582 (rank : 8)	θ value	2.7842e-17 (rank : 10)
Query Neighborhood Hits	126	Target Neighborhood Hits	87	Shared Neighborhood Hits	75
SwissProt Accessions	Q5DU02, Q5SU81, Q66JV8	Gene names	Usp22, Kiaa1063
Domain Architecture	No domain graphic available
Description	Ubiquitin carboxyl-terminal hydrolase 22 (EC 3.1.2.15) (Ubiquitin thioesterase 22) (Ubiquitin-specific-processing protease 22) (Deubiquitinating enzyme 22).

UBP51_HUMAN
NC score	0.842914 (rank : 9)	θ value	3.63628e-17 (rank : 11)
Query Neighborhood Hits	126	Target Neighborhood Hits	162	Shared Neighborhood Hits	78
SwissProt Accessions	Q70EK9, Q8IWJ8	Gene names	USP51
Domain Architecture	No domain graphic available
Description	Ubiquitin carboxyl-terminal hydrolase 51 (EC 3.1.2.15) (Ubiquitin thioesterase 51) (Ubiquitin-specific-processing protease 51) (Deubiquitinating enzyme 51).

UBP33_HUMAN
NC score	0.838691 (rank : 10)	θ value	8.95645e-16 (rank : 19)
Query Neighborhood Hits	126	Target Neighborhood Hits	157	Shared Neighborhood Hits	79
SwissProt Accessions	Q8TEY7, Q8TEY6, Q96AV6, Q9H9F0, Q9UPQ5	Gene names	USP33, KIAA1097, VDU1
Domain Architecture
Description	Ubiquitin carboxyl-terminal hydrolase 33 (EC 3.1.2.15) (Ubiquitin thioesterase 33) (Ubiquitin-specific-processing protease 33) (Deubiquitinating enzyme 33) (VHL-interacting deubiquitinating enzyme 1).

UBP44_HUMAN
NC score	0.838432 (rank : 11)	θ value	1.16975e-15 (rank : 20)
Query Neighborhood Hits	126	Target Neighborhood Hits	91	Shared Neighborhood Hits	77
SwissProt Accessions	Q9H0E7	Gene names	USP44
Domain Architecture
Description	Ubiquitin carboxyl-terminal hydrolase 44 (EC 3.1.2.15) (Ubiquitin thioesterase 44) (Ubiquitin-specific-processing protease 44) (Deubiquitinating enzyme 44).

UBP20_HUMAN
NC score	0.837957 (rank : 12)	θ value	5.8054e-15 (rank : 23)
Query Neighborhood Hits	126	Target Neighborhood Hits	113	Shared Neighborhood Hits	77
SwissProt Accessions	Q9Y2K6, Q96LG5, Q9UQN8, Q9UQP0	Gene names	USP20, KIAA1003, LSFR3A
Domain Architecture
Description	Ubiquitin carboxyl-terminal hydrolase 20 (EC 3.1.2.15) (Ubiquitin thioesterase 20) (Ubiquitin-specific-processing protease 20) (Deubiquitinating enzyme 20).

UBP21_MOUSE
NC score	0.836403 (rank : 13)	θ value	2.69671e-12 (rank : 32)
Query Neighborhood Hits	126	Target Neighborhood Hits	101	Shared Neighborhood Hits	73
SwissProt Accessions	Q9QZL6, Q9D0R1	Gene names	Usp21, Usp23
Domain Architecture
Description	Ubiquitin carboxyl-terminal hydrolase 21 (EC 3.1.2.15) (Ubiquitin thioesterase 21) (Ubiquitin-specific-processing protease 21) (Deubiquitinating enzyme 21).

UBP21_HUMAN
NC score	0.836236 (rank : 14)	θ value	2.69671e-12 (rank : 31)
Query Neighborhood Hits	126	Target Neighborhood Hits	95	Shared Neighborhood Hits	73
SwissProt Accessions	Q9UK80, Q9BTV1, Q9NYN4	Gene names	USP21, USP23
Domain Architecture
Description	Ubiquitin carboxyl-terminal hydrolase 21 (EC 3.1.2.15) (Ubiquitin thioesterase 21) (Ubiquitin-specific-processing protease 21) (Deubiquitinating enzyme 21) (NEDD8-specific protease).

UBP49_MOUSE
NC score	0.836122 (rank : 15)	θ value	9.56915e-18 (rank : 7)
Query Neighborhood Hits	126	Target Neighborhood Hits	91	Shared Neighborhood Hits	78
SwissProt Accessions	Q6P9L4	Gene names	Usp49
Domain Architecture	No domain graphic available
Description	Ubiquitin carboxyl-terminal hydrolase 49 (EC 3.1.2.15) (Ubiquitin thioesterase 49) (Ubiquitin-specific-processing protease 49) (Deubiquitinating enzyme 49).

UBP49_HUMAN
NC score	0.833487 (rank : 16)	θ value	2.13179e-17 (rank : 9)
Query Neighborhood Hits	126	Target Neighborhood Hits	100	Shared Neighborhood Hits	77
SwissProt Accessions	Q70CQ1, Q96CK4	Gene names	USP49
Domain Architecture	No domain graphic available
Description	Ubiquitin carboxyl-terminal hydrolase 49 (EC 3.1.2.15) (Ubiquitin thioesterase 49) (Ubiquitin-specific-processing protease 49) (Deubiquitinating enzyme 49).

UBP8_MOUSE
NC score	0.832721 (rank : 17)	θ value	8.10077e-17 (rank : 16)
Query Neighborhood Hits	126	Target Neighborhood Hits	362	Shared Neighborhood Hits	83
SwissProt Accessions	Q80U87, Q80YP2, Q8R0D3, Q9EQU1, Q9WVP5	Gene names	Usp8, Kiaa0055, Ubpy
Domain Architecture
Description	Ubiquitin carboxyl-terminal hydrolase 8 (EC 3.1.2.15) (Ubiquitin thioesterase 8) (Ubiquitin-specific-processing protease 8) (Deubiquitinating enzyme 8) (mUBPy).

UBP50_HUMAN
NC score	0.827187 (rank : 18)	θ value	7.34386e-10 (rank : 38)
Query Neighborhood Hits	126	Target Neighborhood Hits	75	Shared Neighborhood Hits	68
SwissProt Accessions	Q70EL3	Gene names	USP50
Domain Architecture	No domain graphic available
Description	Inactive ubiquitin carboxyl-terminal hydrolase 50 (Inactive ubiquitin- specific peptidase 50).

UBP12_HUMAN
NC score	0.818916 (rank : 19)	θ value	1.86753e-13 (rank : 26)
Query Neighborhood Hits	126	Target Neighborhood Hits	85	Shared Neighborhood Hits	73
SwissProt Accessions	O75317	Gene names	USP12, UBH1, USP12L1
Domain Architecture
Description	Ubiquitin carboxyl-terminal hydrolase 12 (EC 3.1.2.15) (Ubiquitin thioesterase 12) (Ubiquitin-specific-processing protease 12) (Deubiquitinating enzyme 12) (Ubiquitin-hydrolyzing enzyme 1).

UBP46_HUMAN
NC score	0.815524 (rank : 20)	θ value	2.43908e-13 (rank : 27)
Query Neighborhood Hits	126	Target Neighborhood Hits	81	Shared Neighborhood Hits	73
SwissProt Accessions	P62068, Q80V95, Q9H7U4, Q9H9T8	Gene names	USP46
Domain Architecture
Description	Ubiquitin carboxyl-terminal hydrolase 46 (EC 3.1.2.15) (Ubiquitin thioesterase 46) (Ubiquitin-specific-processing protease 46) (Deubiquitinating enzyme 46).

UBP46_MOUSE
NC score	0.815524 (rank : 21)	θ value	2.43908e-13 (rank : 28)
Query Neighborhood Hits	126	Target Neighborhood Hits	81	Shared Neighborhood Hits	73
SwissProt Accessions	P62069, Q80V95, Q9H7U4, Q9H9T8	Gene names	Usp46
Domain Architecture
Description	Ubiquitin carboxyl-terminal hydrolase 46 (EC 3.1.2.15) (Ubiquitin thioesterase 46) (Ubiquitin-specific-processing protease 46) (Deubiquitinating enzyme 46).

UBP15_MOUSE
NC score	0.813665 (rank : 22)	θ value	1.02238e-19 (rank : 3)
Query Neighborhood Hits	126	Target Neighborhood Hits	88	Shared Neighborhood Hits	73
SwissProt Accessions	Q8R5H1, Q3UL25	Gene names	Usp15
Domain Architecture
Description	Ubiquitin carboxyl-terminal hydrolase 15 (EC 3.1.2.15) (Ubiquitin thioesterase 15) (Ubiquitin-specific-processing protease 15) (Deubiquitinating enzyme 15).

UBPW_MOUSE
NC score	0.813511 (rank : 23)	θ value	3.89403e-11 (rank : 35)
Query Neighborhood Hits	126	Target Neighborhood Hits	89	Shared Neighborhood Hits	73
SwissProt Accessions	Q61068	Gene names	Dub1, Dub-1
Domain Architecture
Description	Ubiquitin carboxyl-terminal hydrolase DUB-1 (EC 3.1.2.15) (Ubiquitin thioesterase DUB-1) (Ubiquitin-specific-processing protease DUB-1) (Deubiquitinating enzyme 1).

UBP15_HUMAN
NC score	0.813309 (rank : 24)	θ value	1.02238e-19 (rank : 2)
Query Neighborhood Hits	126	Target Neighborhood Hits	92	Shared Neighborhood Hits	73
SwissProt Accessions	Q9Y4E8, Q9HCA6, Q9UNP0, Q9Y5B5	Gene names	USP15, KIAA0529
Domain Architecture
Description	Ubiquitin carboxyl-terminal hydrolase 15 (EC 3.1.2.15) (Ubiquitin thioesterase 15) (Ubiquitin-specific-processing protease 15) (Deubiquitinating enzyme 15) (Unph-2) (Unph4).

UBP11_HUMAN
NC score	0.812088 (rank : 25)	θ value	1.80466e-16 (rank : 18)
Query Neighborhood Hits	126	Target Neighborhood Hits	88	Shared Neighborhood Hits	73
SwissProt Accessions	P51784, Q8IUG6, Q9BWE1	Gene names	USP11, UHX1
Domain Architecture
Description	Ubiquitin carboxyl-terminal hydrolase 11 (EC 3.1.2.15) (Ubiquitin thioesterase 11) (Ubiquitin-specific-processing protease 11) (Deubiquitinating enzyme 11).

UBP4_HUMAN
NC score	0.808516 (rank : 26)	θ value	5.60996e-18 (rank : 6)
Query Neighborhood Hits	126	Target Neighborhood Hits	89	Shared Neighborhood Hits	73
SwissProt Accessions	Q13107, O43452, O43453	Gene names	USP4, UNP, UNPH
Domain Architecture
Description	Ubiquitin carboxyl-terminal hydrolase 4 (EC 3.1.2.15) (Ubiquitin thioesterase 4) (Ubiquitin-specific-processing protease 4) (Deubiquitinating enzyme 4) (Ubiquitous nuclear protein homolog).

UBP4_MOUSE
NC score	0.805704 (rank : 27)	θ value	8.10077e-17 (rank : 14)
Query Neighborhood Hits	126	Target Neighborhood Hits	90	Shared Neighborhood Hits	73
SwissProt Accessions	P35123, O54704	Gene names	Usp4, Unp
Domain Architecture
Description	Ubiquitin carboxyl-terminal hydrolase 4 (EC 3.1.2.15) (Ubiquitin thioesterase 4) (Ubiquitin-specific-processing protease 4) (Deubiquitinating enzyme 4) (Ubiquitous nuclear protein).

UBP8_HUMAN
NC score	0.797811 (rank : 28)	θ value	1.38178e-16 (rank : 17)
Query Neighborhood Hits	126	Target Neighborhood Hits	751	Shared Neighborhood Hits	97
SwissProt Accessions	P40818, Q7Z3U2, Q86VA0, Q8IWI7	Gene names	USP8, KIAA0055, UBPY
Domain Architecture
Description	Ubiquitin carboxyl-terminal hydrolase 8 (EC 3.1.2.15) (Ubiquitin thioesterase 8) (Ubiquitin-specific-processing protease 8) (Deubiquitinating enzyme 8) (hUBPy).

UB17L_HUMAN
NC score	0.797400 (rank : 29)	θ value	1.33837e-11 (rank : 33)
Query Neighborhood Hits	126	Target Neighborhood Hits	83	Shared Neighborhood Hits	72
SwissProt Accessions	Q7RTZ2	Gene names	USP17L
Domain Architecture	No domain graphic available
Description	Ubiquitin carboxyl-terminal hydrolase 17-like protein (EC 3.1.2.15) (Ubiquitin thioesterase 17-like) (Ubiquitin-specific-processing protease 17-like) (Deubiquitinating enzyme 17-like).

UBP36_HUMAN
NC score	0.792850 (rank : 30)	θ value	1.42992e-13 (rank : 25)
Query Neighborhood Hits	126	Target Neighborhood Hits	232	Shared Neighborhood Hits	73
SwissProt Accessions	Q9P275, Q8NDM8, Q9NVC8	Gene names	USP36, KIAA1453
Domain Architecture
Description	Ubiquitin carboxyl-terminal hydrolase 36 (EC 3.1.2.15) (Ubiquitin thioesterase 36) (Ubiquitin-specific-processing protease 36) (Deubiquitinating enzyme 36).

UBP43_MOUSE
NC score	0.778304 (rank : 31)	θ value	1.74796e-11 (rank : 34)
Query Neighborhood Hits	126	Target Neighborhood Hits	130	Shared Neighborhood Hits	73
SwissProt Accessions	Q8BUM9, Q8VDP5	Gene names	Usp43
Domain Architecture	No domain graphic available
Description	Ubiquitin carboxyl-terminal hydrolase 43 (EC 3.1.2.15) (Ubiquitin thioesterase 43) (Ubiquitin-specific-processing protease 43) (Deubiquitinating enzyme 43).

UBP43_HUMAN
NC score	0.773659 (rank : 32)	θ value	1.9326e-10 (rank : 36)
Query Neighborhood Hits	126	Target Neighborhood Hits	144	Shared Neighborhood Hits	74
SwissProt Accessions	Q70EL4, Q8N2C5, Q96DQ6	Gene names	USP43
Domain Architecture	No domain graphic available
Description	Ubiquitin carboxyl-terminal hydrolase 43 (EC 3.1.2.15) (Ubiquitin thioesterase 43) (Ubiquitin-specific-processing protease 43) (Deubiquitinating enzyme 43).

UBP31_HUMAN
NC score	0.769781 (rank : 33)	θ value	5.43371e-13 (rank : 29)
Query Neighborhood Hits	126	Target Neighborhood Hits	293	Shared Neighborhood Hits	75
SwissProt Accessions	Q70CQ4, Q6AW97, Q6ZTC0, Q6ZTN2, Q9ULL7	Gene names	USP31, KIAA1203
Domain Architecture	No domain graphic available
Description	Ubiquitin carboxyl-terminal hydrolase 31 (EC 3.1.2.15) (Ubiquitin thioesterase 31) (Ubiquitin-specific-processing protease 31) (Deubiquitinating enzyme 31).

UBP42_HUMAN
NC score	0.769132 (rank : 34)	θ value	7.09661e-13 (rank : 30)
Query Neighborhood Hits	126	Target Neighborhood Hits	445	Shared Neighborhood Hits	75
SwissProt Accessions	Q9H9J4, Q3C166, Q6P9B4	Gene names	USP42
Domain Architecture	No domain graphic available
Description	Ubiquitin carboxyl-terminal hydrolase 42 (EC 3.1.2.15) (Ubiquitin thioesterase 42) (Ubiquitin-specific-processing protease 42) (Deubiquitinating enzyme 42).

UBP18_HUMAN
NC score	0.754337 (rank : 35)	θ value	1.06045e-08 (rank : 40)
Query Neighborhood Hits	126	Target Neighborhood Hits	81	Shared Neighborhood Hits	72
SwissProt Accessions	Q9UMW8, Q9NY71	Gene names	USP18, ISG43
Domain Architecture
Description	Ubl carboxyl-terminal hydrolase 18 (EC 3.1.2.-) (Ubl thioesterase 18) (ISG15-specific-processing protease) (43 kDa ISG15-specific protease) (hUBP43).

UBP1_HUMAN
NC score	0.747740 (rank : 36)	θ value	4.44505e-15 (rank : 21)
Query Neighborhood Hits	126	Target Neighborhood Hits	259	Shared Neighborhood Hits	78
SwissProt Accessions	O94782, Q9UFR0, Q9UNJ3	Gene names	USP1
Domain Architecture
Description	Ubiquitin carboxyl-terminal hydrolase 1 (EC 3.1.2.15) (Ubiquitin thioesterase 1) (Ubiquitin-specific-processing protease 1) (Deubiquitinating enzyme 1) (hUBP).

UBP32_HUMAN
NC score	0.728526 (rank : 37)	θ value	8.10077e-17 (rank : 13)
Query Neighborhood Hits	126	Target Neighborhood Hits	170	Shared Neighborhood Hits	73
SwissProt Accessions	Q8NFA0, Q9BX85, Q9Y591	Gene names	USP32, USP10
Domain Architecture
Description	Ubiquitin carboxyl-terminal hydrolase 32 (EC 3.1.2.15) (Ubiquitin thioesterase 32) (Ubiquitin-specific-processing protease 32) (Deubiquitinating enzyme 32) (NY-REN-60 antigen).

UBP18_MOUSE
NC score	0.727967 (rank : 38)	θ value	4.92598e-06 (rank : 52)
Query Neighborhood Hits	126	Target Neighborhood Hits	77	Shared Neighborhood Hits	69
SwissProt Accessions	Q9WTV6	Gene names	Usp18, Ubp43
Domain Architecture
Description	Ubl carboxyl-terminal hydrolase 18 (EC 3.1.2.-) (Ubl thioesterase 18) (ISG15-specific-processing protease) (43 kDa ISG15-specific protease).

UBP48_HUMAN
NC score	0.726955 (rank : 39)	θ value	1.53129e-07 (rank : 46)
Query Neighborhood Hits	126	Target Neighborhood Hits	101	Shared Neighborhood Hits	73
SwissProt Accessions	Q86UV5, Q2M3I4, Q5SZI4, Q5T3T5, Q6NX53, Q8N3F6, Q96F64, Q96IQ3, Q9H5N3, Q9H5T7, Q9NUJ6, Q9NXR0	Gene names	USP48
Domain Architecture	No domain graphic available
Description	Ubiquitin carboxyl-terminal hydrolase 48 (EC 3.1.2.15) (Ubiquitin thioesterase 48) (Ubiquitin-specific-processing protease 48) (Deubiquitinating enzyme 48).

UBP48_MOUSE
NC score	0.722098 (rank : 40)	θ value	1.69304e-06 (rank : 50)
Query Neighborhood Hits	126	Target Neighborhood Hits	124	Shared Neighborhood Hits	75
SwissProt Accessions	Q3V0C5, Q3TM39, Q571J9, Q8VDJ1	Gene names	Usp48, Kiaa4202
Domain Architecture	No domain graphic available
Description	Ubiquitin carboxyl-terminal hydrolase 48 (EC 3.1.2.15) (Ubiquitin thioesterase 48) (Ubiquitin-specific-processing protease 48) (Deubiquitinating enzyme 48).

UBP30_HUMAN
NC score	0.721366 (rank : 41)	θ value	1.69304e-06 (rank : 49)
Query Neighborhood Hits	126	Target Neighborhood Hits	94	Shared Neighborhood Hits	70
SwissProt Accessions	Q70CQ3, Q8WTU7, Q96JX4, Q9BSS3	Gene names	USP30
Domain Architecture	No domain graphic available
Description	Ubiquitin carboxyl-terminal hydrolase 30 (EC 3.1.2.15) (Ubiquitin thioesterase 30) (Ubiquitin-specific-processing protease 30) (Deubiquitinating enzyme 30).

UBP35_HUMAN
NC score	0.696790 (rank : 42)	θ value	1.06045e-08 (rank : 41)
Query Neighborhood Hits	126	Target Neighborhood Hits	223	Shared Neighborhood Hits	78
SwissProt Accessions	Q9P2H5	Gene names	USP35, KIAA1372, USP34
Domain Architecture
Description	Ubiquitin carboxyl-terminal hydrolase 35 (EC 3.1.2.15) (Ubiquitin thioesterase 35) (Ubiquitin-specific-processing protease 35) (Deubiquitinating enzyme 35).

UBP6_HUMAN
NC score	0.688422 (rank : 43)	θ value	8.10077e-17 (rank : 15)
Query Neighborhood Hits	126	Target Neighborhood Hits	188	Shared Neighborhood Hits	73
SwissProt Accessions	P35125, Q15634, Q86WP6, Q8IWT4	Gene names	USP6, TRE2
Domain Architecture
Description	Ubiquitin carboxyl-terminal hydrolase 6 (EC 3.1.2.15) (Ubiquitin thioesterase 6) (Ubiquitin-specific-processing protease 6) (Deubiquitinating enzyme 6) (Proto-oncogene TRE-2).

UBP38_HUMAN
NC score	0.672197 (rank : 44)	θ value	7.34386e-10 (rank : 37)
Query Neighborhood Hits	126	Target Neighborhood Hits	97	Shared Neighborhood Hits	72
SwissProt Accessions	Q8NB14, Q8NDF5, Q96DK6, Q96PZ6, Q9BY55	Gene names	USP38, KIAA1891
Domain Architecture
Description	Ubiquitin carboxyl-terminal hydrolase 38 (EC 3.1.2.15) (Ubiquitin thioesterase 38) (Ubiquitin-specific-processing protease 38) (Deubiquitinating enzyme 38) (HP43.8KD).

UBP38_MOUSE
NC score	0.669150 (rank : 45)	θ value	8.11959e-09 (rank : 39)
Query Neighborhood Hits	126	Target Neighborhood Hits	100	Shared Neighborhood Hits	71
SwissProt Accessions	Q8BW70, Q8BWL1, Q8BX03	Gene names	Usp38
Domain Architecture
Description	Ubiquitin carboxyl-terminal hydrolase 38 (EC 3.1.2.15) (Ubiquitin thioesterase 38) (Ubiquitin-specific-processing protease 38) (Deubiquitinating enzyme 38).

UBP24_HUMAN
NC score	0.665476 (rank : 46)	θ value	5.81887e-07 (rank : 48)
Query Neighborhood Hits	126	Target Neighborhood Hits	96	Shared Neighborhood Hits	71
SwissProt Accessions	Q9UPU5, Q6ZSY2, Q8N2Y4, Q9NXD1	Gene names	USP24, KIAA1057
Domain Architecture	No domain graphic available
Description	Ubiquitin carboxyl-terminal hydrolase 24 (EC 3.1.2.15) (Ubiquitin thioesterase 24) (Ubiquitin-specific-processing protease 24) (Deubiquitinating enzyme 24).

UBP10_MOUSE
NC score	0.663391 (rank : 47)	θ value	1.43324e-05 (rank : 53)
Query Neighborhood Hits	126	Target Neighborhood Hits	150	Shared Neighborhood Hits	69
SwissProt Accessions	P52479, Q91VY7	Gene names	Usp10, Ode-1, Uchrp
Domain Architecture
Description	Ubiquitin carboxyl-terminal hydrolase 10 (EC 3.1.2.15) (Ubiquitin thioesterase 10) (Ubiquitin-specific-processing protease 10) (Deubiquitinating enzyme 10).

UBP40_HUMAN
NC score	0.657566 (rank : 48)	θ value	0.00035302 (rank : 58)
Query Neighborhood Hits	126	Target Neighborhood Hits	81	Shared Neighborhood Hits	71
SwissProt Accessions	Q9NVE5, Q6NX38, Q70EL0	Gene names	USP40
Domain Architecture	No domain graphic available
Description	Ubiquitin carboxyl-terminal hydrolase 40 (EC 3.1.2.15) (Ubiquitin thioesterase 40) (Ubiquitin-specific-processing protease 40) (Deubiquitinating enzyme 40).

UBP10_HUMAN
NC score	0.656830 (rank : 49)	θ value	1.87187e-05 (rank : 54)
Query Neighborhood Hits	126	Target Neighborhood Hits	153	Shared Neighborhood Hits	70
SwissProt Accessions	Q14694, Q9BWG7, Q9NSL7	Gene names	USP10, KIAA0190
Domain Architecture
Description	Ubiquitin carboxyl-terminal hydrolase 10 (EC 3.1.2.15) (Ubiquitin thioesterase 10) (Ubiquitin-specific-processing protease 10) (Deubiquitinating enzyme 10).

UBP7_HUMAN
NC score	0.655479 (rank : 50)	θ value	0.000786445 (rank : 62)
Query Neighborhood Hits	126	Target Neighborhood Hits	93	Shared Neighborhood Hits	70
SwissProt Accessions	Q93009	Gene names	USP7, HAUSP
Domain Architecture
Description	Ubiquitin carboxyl-terminal hydrolase 7 (EC 3.1.2.15) (Ubiquitin thioesterase 7) (Ubiquitin-specific-processing protease 7) (Deubiquitinating enzyme 7) (Herpesvirus-associated ubiquitin-specific protease).

UBP37_HUMAN
NC score	0.635576 (rank : 51)	θ value	5.26297e-08 (rank : 44)
Query Neighborhood Hits	126	Target Neighborhood Hits	208	Shared Neighborhood Hits	75
SwissProt Accessions	Q86T82, Q9HCH8	Gene names	USP37, KIAA1594
Domain Architecture
Description	Ubiquitin carboxyl-terminal hydrolase 37 (EC 3.1.2.15) (Ubiquitin thioesterase 37) (Ubiquitin-specific-processing protease 37) (Deubiquitinating enzyme 37).

UBP47_MOUSE
NC score	0.632051 (rank : 52)	θ value	0.00102713 (rank : 64)
Query Neighborhood Hits	126	Target Neighborhood Hits	135	Shared Neighborhood Hits	71
SwissProt Accessions	Q8BY87, Q5EBP2, Q6KAR9, Q80V06, Q8BHU1, Q8BI15, Q8BI16, Q8BUW4, Q91X25	Gene names	Usp47
Domain Architecture	No domain graphic available
Description	Ubiquitin carboxyl-terminal hydrolase 47 (EC 3.1.2.15) (Ubiquitin thioesterase 47) (Ubiquitin-specific-processing protease 47) (Deubiquitinating enzyme 47).

UBP47_HUMAN
NC score	0.627468 (rank : 53)	θ value	0.00175202 (rank : 66)
Query Neighborhood Hits	126	Target Neighborhood Hits	149	Shared Neighborhood Hits	73
SwissProt Accessions	Q96K76, Q658U0, Q86Y73, Q8TEP6, Q9BWI0, Q9NWN1	Gene names	USP47
Domain Architecture	No domain graphic available
Description	Ubiquitin carboxyl-terminal hydrolase 47 (EC 3.1.2.15) (Ubiquitin thioesterase 47) (Ubiquitin-specific-processing protease 47) (Deubiquitinating enzyme 47).

UBP14_HUMAN
NC score	0.613969 (rank : 54)	θ value	0.00020696 (rank : 55)
Query Neighborhood Hits	126	Target Neighborhood Hits	89	Shared Neighborhood Hits	71
SwissProt Accessions	P54578	Gene names	USP14, TGT
Domain Architecture
Description	Ubiquitin carboxyl-terminal hydrolase 14 (EC 3.1.2.15) (Ubiquitin thioesterase 14) (Ubiquitin-specific-processing protease 14) (Deubiquitinating enzyme 14).

UBP14_MOUSE
NC score	0.597521 (rank : 55)	θ value	0.00102713 (rank : 63)
Query Neighborhood Hits	126	Target Neighborhood Hits	87	Shared Neighborhood Hits	70
SwissProt Accessions	Q9JMA1, Q543U5, Q923F2, Q9D0L0	Gene names	Usp14
Domain Architecture
Description	Ubiquitin carboxyl-terminal hydrolase 14 (EC 3.1.2.15) (Ubiquitin thioesterase 14) (Ubiquitin-specific-processing protease 14) (Deubiquitinating enzyme 14).

SNUT2_MOUSE
NC score	0.597035 (rank : 56)	θ value	0.0113563 (rank : 72)
Query Neighborhood Hits	126	Target Neighborhood Hits	80	Shared Neighborhood Hits	62
SwissProt Accessions	Q3TIX9, Q3TI55, Q8BLI5, Q8BZZ5, Q9CQR1	Gene names	Usp39
Domain Architecture	No domain graphic available
Description	U4/U6.U5 tri-snRNP-associated protein 2 (Inactive ubiquitin-specific peptidase 39).

USP9X_HUMAN
NC score	0.595709 (rank : 57)	θ value	1.17247e-07 (rank : 45)
Query Neighborhood Hits	126	Target Neighborhood Hits	161	Shared Neighborhood Hits	74
SwissProt Accessions	Q93008, O75550, Q8WWT3, Q8WX12	Gene names	USP9X, DFFRX, USP9
Domain Architecture
Description	Probable ubiquitin carboxyl-terminal hydrolase FAF-X (EC 3.1.2.15) (Ubiquitin thioesterase FAF-X) (Ubiquitin-specific-processing protease FAF-X) (Deubiquitinating enzyme FAF-X) (Fat facets protein-related, X- linked) (Ubiquitin-specific protease 9, X chromosome).

USP9X_MOUSE
NC score	0.594202 (rank : 58)	θ value	1.53129e-07 (rank : 47)
Query Neighborhood Hits	126	Target Neighborhood Hits	171	Shared Neighborhood Hits	74
SwissProt Accessions	P70398, Q62497	Gene names	Usp9x, Fafl, Fam
Domain Architecture
Description	Probable ubiquitin carboxyl-terminal hydrolase FAF-X (EC 3.1.2.15) (Ubiquitin thioesterase FAF-X) (Ubiquitin-specific-processing protease FAF-X) (Deubiquitinating enzyme FAF-X) (Fat facets protein-related, X- linked) (Ubiquitin-specific protease 9, X chromosome) (Ubiquitin carboxyl-terminal hydrolase FAM) (Fat facets homolog).

USP9Y_HUMAN
NC score	0.591604 (rank : 59)	θ value	3.77169e-06 (rank : 51)
Query Neighborhood Hits	126	Target Neighborhood Hits	109	Shared Neighborhood Hits	74
SwissProt Accessions	O00507, O14601	Gene names	USP9Y, DFFRY, USP10
Domain Architecture
Description	Probable ubiquitin carboxyl-terminal hydrolase FAF-Y (EC 3.1.2.15) (Ubiquitin thioesterase FAF-Y) (Ubiquitin-specific-processing protease FAF-Y) (Deubiquitinating enzyme FAF-Y) (Fat facets protein-related, Y- linked) (Ubiquitin-specific protease 9, Y chromosome).

SNUT2_HUMAN
NC score	0.586553 (rank : 60)	θ value	0.0113563 (rank : 71)
Query Neighborhood Hits	126	Target Neighborhood Hits	79	Shared Neighborhood Hits	61
SwissProt Accessions	Q53GS9, Q6NX47, Q96RK9, Q9BV89, Q9H381, Q9P050, Q9Y310	Gene names	USP39
Domain Architecture	No domain graphic available
Description	U4/U6.U5 tri-snRNP-associated protein 2 (U4/U6.U5 tri-snRNP-associated 65 kDa protein) (65K) (Inactive ubiquitin-specific peptidase 39) (SAD1 homolog).

UBP34_MOUSE
NC score	0.577190 (rank : 61)	θ value	0.00665767 (rank : 68)
Query Neighborhood Hits	126	Target Neighborhood Hits	189	Shared Neighborhood Hits	71
SwissProt Accessions	Q6ZQ93, Q3UPN0, Q6P563, Q7TMJ6, Q8CCH0	Gene names	Usp34, Kiaa0570
Domain Architecture	No domain graphic available
Description	Ubiquitin carboxyl-terminal hydrolase 34 (EC 3.1.2.15) (Ubiquitin thioesterase 34) (Ubiquitin-specific-processing protease 34) (Deubiquitinating enzyme 34).

UBP34_HUMAN
NC score	0.577032 (rank : 62)	θ value	0.00509761 (rank : 67)
Query Neighborhood Hits	126	Target Neighborhood Hits	210	Shared Neighborhood Hits	70
SwissProt Accessions	Q70CQ2, O60316, O94834, Q3B777, Q6P6C9, Q7L8P6, Q8N3T9, Q8TBW2, Q9UGA1	Gene names	USP34, KIAA0570, KIAA0729
Domain Architecture	No domain graphic available
Description	Ubiquitin carboxyl-terminal hydrolase 34 (EC 3.1.2.15) (Ubiquitin thioesterase 34) (Ubiquitin-specific-processing protease 34) (Deubiquitinating enzyme 34).

UBP29_HUMAN
NC score	0.551613 (rank : 63)	θ value	0.000786445 (rank : 61)
Query Neighborhood Hits	126	Target Neighborhood Hits	94	Shared Neighborhood Hits	71
SwissProt Accessions	Q9HBJ7	Gene names	USP29
Domain Architecture
Description	Ubiquitin carboxyl-terminal hydrolase 29 (EC 3.1.2.15) (Ubiquitin thioesterase 29) (Ubiquitin-specific-processing protease 29) (Deubiquitinating enzyme 29).

UBP26_HUMAN
NC score	0.537054 (rank : 64)	θ value	0.00175202 (rank : 65)
Query Neighborhood Hits	126	Target Neighborhood Hits	108	Shared Neighborhood Hits	71
SwissProt Accessions	Q9BXU7	Gene names	USP26
Domain Architecture
Description	Ubiquitin carboxyl-terminal hydrolase 26 (EC 3.1.2.15) (Ubiquitin thioesterase 26) (Ubiquitin-specific-processing protease 26) (Deubiquitinating enzyme 26).

UBP29_MOUSE
NC score	0.523597 (rank : 65)	θ value	0.0193708 (rank : 73)
Query Neighborhood Hits	126	Target Neighborhood Hits	95	Shared Neighborhood Hits	72
SwissProt Accessions	Q9ES63	Gene names	Usp29
Domain Architecture
Description	Ubiquitin carboxyl-terminal hydrolase 29 (EC 3.1.2.15) (Ubiquitin thioesterase 29) (Ubiquitin-specific-processing protease 29) (Deubiquitinating enzyme 29).

UBP13_HUMAN
NC score	0.476034 (rank : 66)	θ value	0.0330416 (rank : 75)
Query Neighborhood Hits	126	Target Neighborhood Hits	99	Shared Neighborhood Hits	76
SwissProt Accessions	Q92995	Gene names	USP13, ISOT3
Domain Architecture
Description	Ubiquitin carboxyl-terminal hydrolase 13 (EC 3.1.2.15) (Ubiquitin thioesterase 13) (Ubiquitin-specific-processing protease 13) (Deubiquitinating enzyme 13) (Isopeptidase T-3) (ISOT-3).

UBP5_HUMAN
NC score	0.474273 (rank : 67)	θ value	0.279714 (rank : 84)
Query Neighborhood Hits	126	Target Neighborhood Hits	109	Shared Neighborhood Hits	76
SwissProt Accessions	P45974, Q96J22	Gene names	USP5, ISOT
Domain Architecture
Description	Ubiquitin carboxyl-terminal hydrolase 5 (EC 3.1.2.15) (Ubiquitin thioesterase 5) (Ubiquitin-specific-processing protease 5) (Deubiquitinating enzyme 5) (Isopeptidase T).

UBP5_MOUSE
NC score	0.470424 (rank : 68)	θ value	0.279714 (rank : 85)
Query Neighborhood Hits	126	Target Neighborhood Hits	106	Shared Neighborhood Hits	76
SwissProt Accessions	P56399	Gene names	Usp5, Isot
Domain Architecture
Description	Ubiquitin carboxyl-terminal hydrolase 5 (EC 3.1.2.15) (Ubiquitin thioesterase 5) (Ubiquitin-specific-processing protease 5) (Deubiquitinating enzyme 5) (Isopeptidase T).

UBP26_MOUSE
NC score	0.435478 (rank : 69)	θ value	0.279714 (rank : 83)
Query Neighborhood Hits	126	Target Neighborhood Hits	107	Shared Neighborhood Hits	70
SwissProt Accessions	Q99MX1	Gene names	Usp26
Domain Architecture
Description	Ubiquitin carboxyl-terminal hydrolase 26 (EC 3.1.2.15) (Ubiquitin thioesterase 26) (Ubiquitin-specific-processing protease 26) (Deubiquitinating enzyme 26).

UBP28_HUMAN
NC score	0.427812 (rank : 70)	θ value	0.000602161 (rank : 59)
Query Neighborhood Hits	126	Target Neighborhood Hits	117	Shared Neighborhood Hits	74
SwissProt Accessions	Q96RU2, Q9P213	Gene names	USP28, KIAA1515
Domain Architecture
Description	Ubiquitin carboxyl-terminal hydrolase 28 (EC 3.1.2.15) (Ubiquitin thioesterase 28) (Ubiquitin-specific-processing protease 28) (Deubiquitinating enzyme 28).

UBP28_MOUSE
NC score	0.422964 (rank : 71)	θ value	0.000602161 (rank : 60)
Query Neighborhood Hits	126	Target Neighborhood Hits	178	Shared Neighborhood Hits	73
SwissProt Accessions	Q5I043, Q6NZP3, Q6ZPP1, Q8BWI1	Gene names	Usp28, Kiaa1515
Domain Architecture	No domain graphic available
Description	Ubiquitin carboxyl-terminal hydrolase 28 (EC 3.1.2.15) (Ubiquitin thioesterase 28) (Ubiquitin-specific-processing protease 28) (Deubiquitinating enzyme 28).

UBP25_MOUSE
NC score	0.410105 (rank : 72)	θ value	0.00035302 (rank : 57)
Query Neighborhood Hits	126	Target Neighborhood Hits	116	Shared Neighborhood Hits	72
SwissProt Accessions	P57080, Q80ZT9	Gene names	Usp25
Domain Architecture
Description	Ubiquitin carboxyl-terminal hydrolase 25 (EC 3.1.2.15) (Ubiquitin thioesterase 25) (Ubiquitin-specific-processing protease 25) (Deubiquitinating enzyme 25) (mUSP25).

UBP25_HUMAN
NC score	0.408513 (rank : 73)	θ value	0.000270298 (rank : 56)
Query Neighborhood Hits	126	Target Neighborhood Hits	124	Shared Neighborhood Hits	72
SwissProt Accessions	Q9UHP3, Q9H9W1	Gene names	USP25, USP21
Domain Architecture
Description	Ubiquitin carboxyl-terminal hydrolase 25 (EC 3.1.2.15) (Ubiquitin thioesterase 25) (Ubiquitin-specific-processing protease 25) (Deubiquitinating enzyme 25) (USP on chromosome 21).

BRAP_MOUSE
NC score	0.265285 (rank : 74)	θ value	1.38499e-08 (rank : 43)
Query Neighborhood Hits	126	Target Neighborhood Hits	409	Shared Neighborhood Hits	36
SwissProt Accessions	Q99MP8, Q8CC00, Q8CHX1, Q99MP7, Q9CXX8	Gene names	Brap
Domain Architecture	No domain graphic available
Description	BRCA1-associated protein (EC 6.3.2.-) (BRAP2) (Impedes mitogenic signal propagation) (IMP).

BRAP_HUMAN
NC score	0.235171 (rank : 75)	θ value	1.38499e-08 (rank : 42)
Query Neighborhood Hits	126	Target Neighborhood Hits	560	Shared Neighborhood Hits	38
SwissProt Accessions	Q7Z569, O43238, O75341	Gene names	BRAP, RNF52
Domain Architecture	No domain graphic available
Description	BRCA1-associated protein (EC 6.3.2.-) (BRAP2) (Impedes mitogenic signal propagation) (IMP) (RING finger protein 52) (NY-REN-63 antigen).

HDAC6_MOUSE
NC score	0.138528 (rank : 76)	θ value	0.0113563 (rank : 70)
Query Neighborhood Hits	126	Target Neighborhood Hits	88	Shared Neighborhood Hits	17
SwissProt Accessions	Q9Z2V5	Gene names	Hdac6
Domain Architecture
Description	Histone deacetylase 6 (HD6) (Histone deacetylase mHDA2).

HDAC6_HUMAN
NC score	0.131199 (rank : 77)	θ value	0.0113563 (rank : 69)
Query Neighborhood Hits	126	Target Neighborhood Hits	145	Shared Neighborhood Hits	19
SwissProt Accessions	Q9UBN7	Gene names	HDAC6
Domain Architecture
Description	Histone deacetylase 6 (HD6).

GGNB1_MOUSE
NC score	0.110995 (rank : 78)	θ value	θ > 10 (rank : 128)
Query Neighborhood Hits	126	Target Neighborhood Hits	23	Shared Neighborhood Hits	5
SwissProt Accessions	Q6K1E7, Q8C5T9	Gene names	Ggnbp1
Domain Architecture	No domain graphic available
Description	Gametogenetin-binding protein 1.

GGNB1_HUMAN
NC score	0.084415 (rank : 79)	θ value	θ > 10 (rank : 127)
Query Neighborhood Hits	126	Target Neighborhood Hits	10	Shared Neighborhood Hits	5
SwissProt Accessions	Q5YKI7, Q5YKI8	Gene names	GGNBP1
Domain Architecture	No domain graphic available
Description	Gametogenetin-binding protein 1.

TBCD3_HUMAN
NC score	0.065221 (rank : 80)	θ value	θ > 10 (rank : 129)
Query Neighborhood Hits	126	Target Neighborhood Hits	51	Shared Neighborhood Hits	1
SwissProt Accessions	Q8IZP1, Q9H0B9, Q9UDD4	Gene names	TBC1D3, PRC17
Domain Architecture
Description	TBC1 domain family member 3 (Rab GTPase-activating protein PRC17) (Prostate cancer gene 17 protein) (TRE17 alpha protein).

UBP54_MOUSE
NC score	0.053879 (rank : 81)	θ value	θ > 10 (rank : 131)
Query Neighborhood Hits	126	Target Neighborhood Hits	19	Shared Neighborhood Hits	13
SwissProt Accessions	Q8BL06, Q8BZ28	Gene names	Usp54
Domain Architecture	No domain graphic available
Description	Inactive ubiquitin carboxyl-terminal hydrolase 54 (Inactive ubiquitin- specific peptidase 54).

UBP54_HUMAN
NC score	0.052727 (rank : 82)	θ value	θ > 10 (rank : 130)
Query Neighborhood Hits	126	Target Neighborhood Hits	21	Shared Neighborhood Hits	14
SwissProt Accessions	Q70EL1, Q5F2F4	Gene names	USP54, C10orf29
Domain Architecture	No domain graphic available
Description	Inactive ubiquitin carboxyl-terminal hydrolase 54 (Inactive ubiquitin- specific peptidase 54).

CCD21_MOUSE
NC score	0.044111 (rank : 83)	θ value	0.0330416 (rank : 74)
Query Neighborhood Hits	126	Target Neighborhood Hits	1135	Shared Neighborhood Hits	30
SwissProt Accessions	Q8BMK0, Q8BUF1, Q8K0E6	Gene names	Ccdc21
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 21.

CCD21_HUMAN
NC score	0.042928 (rank : 84)	θ value	0.0563607 (rank : 77)
Query Neighborhood Hits	126	Target Neighborhood Hits	1228	Shared Neighborhood Hits	35
SwissProt Accessions	Q6P2H3, Q5VY68, Q5VY70, Q9H6Q1, Q9H828, Q9UF52	Gene names	CCDC21
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 21.

NOL8_HUMAN
NC score	0.039401 (rank : 85)	θ value	0.279714 (rank : 82)
Query Neighborhood Hits	126	Target Neighborhood Hits	297	Shared Neighborhood Hits	8
SwissProt Accessions	Q76FK4, Q5TCC7, Q5TCC8, Q5TCD3, Q5TCD5, Q5TCD6, Q5TCD7, Q76D35, Q7L3E2, Q9H586, Q9H795, Q9H7W7, Q9H9J6, Q9NWA4, Q9NWM4	Gene names	NOL8, NOP132
Domain Architecture	No domain graphic available
Description	Nucleolar protein 8 (Nucleolar protein Nop132).

NEB1_HUMAN
NC score	0.034036 (rank : 86)	θ value	0.163984 (rank : 80)
Query Neighborhood Hits	126	Target Neighborhood Hits	829	Shared Neighborhood Hits	29
SwissProt Accessions	Q9ULJ8, O76059, Q9NXT2	Gene names	PPP1R9A, KIAA1222
Domain Architecture	No domain graphic available
Description	Neurabin-1 (Neurabin-I) (Neural tissue-specific F-actin-binding protein I) (Protein phosphatase 1 regulatory subunit 9A).

CCD46_MOUSE
NC score	0.033407 (rank : 87)	θ value	0.0961366 (rank : 78)
Query Neighborhood Hits	126	Target Neighborhood Hits	1405	Shared Neighborhood Hits	32
SwissProt Accessions	Q5PR68, Q80ZN6, Q99JS4, Q9D9T1	Gene names	Ccdc46
Domain Architecture	No domain graphic available
Description	Coiled coil domain-containing protein 46.

RIOK1_HUMAN
NC score	0.029800 (rank : 88)	θ value	1.06291 (rank : 98)
Query Neighborhood Hits	126	Target Neighborhood Hits	86	Shared Neighborhood Hits	4
SwissProt Accessions	Q9BRS2, Q8NDC8, Q96NV9	Gene names	RIOK1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase RIO1 (EC 2.7.11.1) (RIO kinase 1).

RTN4_MOUSE
NC score	0.029396 (rank : 89)	θ value	0.365318 (rank : 89)
Query Neighborhood Hits	126	Target Neighborhood Hits	341	Shared Neighborhood Hits	9
SwissProt Accessions	Q99P72, Q5DTK9, Q7TNB7, Q80W95, Q8BGK7, Q8BGM9, Q8K290, Q8K3G8, Q9CTE3	Gene names	Rtn4, Kiaa0886, Nogo
Domain Architecture
Description	Reticulon-4 (Neurite outgrowth inhibitor) (Nogo protein).

CN145_HUMAN
NC score	0.028823 (rank : 90)	θ value	0.62314 (rank : 94)
Query Neighborhood Hits	126	Target Neighborhood Hits	1196	Shared Neighborhood Hits	27
SwissProt Accessions	Q6ZU80, Q96ML4	Gene names	C14orf145
Domain Architecture	No domain graphic available
Description	Protein C14orf145.

CCD46_HUMAN
NC score	0.028673 (rank : 91)	θ value	1.06291 (rank : 97)
Query Neighborhood Hits	126	Target Neighborhood Hits	1430	Shared Neighborhood Hits	28
SwissProt Accessions	Q8N8E3, Q6PIB5, Q8NCR4, Q8NFR4	Gene names	CCDC46
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 46.

REST_HUMAN
NC score	0.027381 (rank : 92)	θ value	0.0431538 (rank : 76)
Query Neighborhood Hits	126	Target Neighborhood Hits	1605	Shared Neighborhood Hits	34
SwissProt Accessions	P30622	Gene names	RSN, CYLN1
Domain Architecture
Description	Restin (Cytoplasmic linker protein 170 alpha-2) (CLIP-170) (Reed- Sternberg intermediate filament-associated protein) (Cytoplasmic linker protein 1).

GAS8_HUMAN
NC score	0.025843 (rank : 93)	θ value	1.38821 (rank : 99)
Query Neighborhood Hits	126	Target Neighborhood Hits	819	Shared Neighborhood Hits	25
SwissProt Accessions	O95995	Gene names	GAS8, GAS11
Domain Architecture	No domain graphic available
Description	Growth-arrest-specific protein 8 (Growth arrest-specific 11).

ZCHC6_HUMAN
NC score	0.025792 (rank : 94)	θ value	0.47712 (rank : 93)
Query Neighborhood Hits	126	Target Neighborhood Hits	142	Shared Neighborhood Hits	7
SwissProt Accessions	Q5VYS8, Q5H9T0, Q5VYS5, Q5VYS7, Q658Z9, Q659A2, Q6MZJ3, Q8N5F0, Q96N57, Q96NE8, Q9C0F2, Q9H8M6	Gene names	ZCCHC6, KIAA1711
Domain Architecture	No domain graphic available
Description	Zinc finger CCHC domain-containing protein 6.

CCD41_MOUSE
NC score	0.025774 (rank : 95)	θ value	0.47712 (rank : 90)
Query Neighborhood Hits	126	Target Neighborhood Hits	1399	Shared Neighborhood Hits	30
SwissProt Accessions	Q9D5R3, Q3U7X7, Q3UX57, Q80VF0	Gene names	Ccdc41
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 41.

MINT_HUMAN
NC score	0.025083 (rank : 96)	θ value	0.47712 (rank : 91)
Query Neighborhood Hits	126	Target Neighborhood Hits	1291	Shared Neighborhood Hits	27
SwissProt Accessions	Q96T58, Q9H9A8, Q9NWH5, Q9UQ01, Q9Y556	Gene names	SPEN, KIAA0929, MINT, SHARP
Domain Architecture
Description	Msx2-interacting protein (SPEN homolog) (SMART/HDAC1-associated repressor protein).

SMC2_HUMAN
NC score	0.024742 (rank : 97)	θ value	0.62314 (rank : 96)
Query Neighborhood Hits	126	Target Neighborhood Hits	1405	Shared Neighborhood Hits	33
SwissProt Accessions	O95347, Q9P1P2	Gene names	SMC2L1, CAPE, SMC2
Domain Architecture
Description	Structural maintenance of chromosome 2-like 1 protein (Chromosome- associated protein E) (hCAP-E) (XCAP-E homolog).

SEC63_HUMAN
NC score	0.024704 (rank : 98)	θ value	2.36792 (rank : 101)
Query Neighborhood Hits	126	Target Neighborhood Hits	586	Shared Neighborhood Hits	13
SwissProt Accessions	Q9UGP8, O95380, Q86VS9, Q8IWL0, Q9NTE0	Gene names	SEC63, SEC63L
Domain Architecture
Description	Translocation protein SEC63 homolog.

UBA3_HUMAN
NC score	0.024124 (rank : 99)	θ value	2.36792 (rank : 102)
Query Neighborhood Hits	126	Target Neighborhood Hits	22	Shared Neighborhood Hits	3
SwissProt Accessions	Q8TBC4, O76088, Q9NTU3	Gene names	UBE1C, UBA3
Domain Architecture	No domain graphic available
Description	NEDD8-activating enzyme E1 catalytic subunit (EC 6.3.2.-) (Ubiquitin- activating enzyme 3) (NEDD8-activating enzyme E1C) (Ubiquitin- activating enzyme E1C).

UBA3_MOUSE
NC score	0.024107 (rank : 100)	θ value	2.36792 (rank : 103)
Query Neighborhood Hits	126	Target Neighborhood Hits	22	Shared Neighborhood Hits	3
SwissProt Accessions	Q8C878, O88598, Q9D6B7	Gene names	Ube1c, Uba3
Domain Architecture	No domain graphic available
Description	NEDD8-activating enzyme E1 catalytic subunit (EC 6.3.2.-) (Ubiquitin- activating enzyme 3) (NEDD8-activating enzyme E1C) (Ubiquitin- activating enzyme E1C).

CI039_HUMAN
NC score	0.023899 (rank : 101)	θ value	8.99809 (rank : 121)
Query Neighborhood Hits	126	Target Neighborhood Hits	1171	Shared Neighborhood Hits	31
SwissProt Accessions	Q9NXG0, Q5VYJ0, Q9HAJ5	Gene names	C9orf39
Domain Architecture	No domain graphic available
Description	Protein C9orf39.

UACA_HUMAN
NC score	0.022882 (rank : 102)	θ value	0.125558 (rank : 79)
Query Neighborhood Hits	126	Target Neighborhood Hits	1622	Shared Neighborhood Hits	26
SwissProt Accessions	Q9BZF9, Q8N3B8, Q9HCL1, Q9NWC6	Gene names	UACA, KIAA1561
Domain Architecture	No domain graphic available
Description	Uveal autoantigen with coiled-coil domains and ankyrin repeats protein.

MYH11_MOUSE
NC score	0.022322 (rank : 103)	θ value	0.365318 (rank : 88)
Query Neighborhood Hits	126	Target Neighborhood Hits	1777	Shared Neighborhood Hits	34
SwissProt Accessions	O08638, O08639, Q62462, Q64195	Gene names	Myh11
Domain Architecture
Description	Myosin-11 (Myosin heavy chain, smooth muscle isoform) (SMMHC).

CCD96_MOUSE
NC score	0.021844 (rank : 104)	θ value	8.99809 (rank : 120)
Query Neighborhood Hits	126	Target Neighborhood Hits	704	Shared Neighborhood Hits	28
SwissProt Accessions	Q9CR92	Gene names	Ccdc96
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 96.

SEC63_MOUSE
NC score	0.021518 (rank : 105)	θ value	4.03905 (rank : 108)
Query Neighborhood Hits	126	Target Neighborhood Hits	601	Shared Neighborhood Hits	15
SwissProt Accessions	Q8VHE0, Q8VEB9	Gene names	Sec63, Sec63l
Domain Architecture
Description	Translocation protein SEC63 homolog.

MYH11_HUMAN
NC score	0.021430 (rank : 106)	θ value	0.365318 (rank : 87)
Query Neighborhood Hits	126	Target Neighborhood Hits	1806	Shared Neighborhood Hits	31
SwissProt Accessions	P35749, O00396, O94944, P78422	Gene names	MYH11, KIAA0866
Domain Architecture
Description	Myosin-11 (Myosin heavy chain, smooth muscle isoform) (SMMHC).

TRIPB_HUMAN
NC score	0.020166 (rank : 107)	θ value	6.88961 (rank : 116)
Query Neighborhood Hits	126	Target Neighborhood Hits	1587	Shared Neighborhood Hits	31
SwissProt Accessions	Q15643, O14689, O15154, O95949	Gene names	TRIP11, CEV14
Domain Architecture	No domain graphic available
Description	Thyroid receptor-interacting protein 11 (TRIP-11) (Golgi-associated microtubule-binding protein 210) (GMAP-210) (Trip230) (Clonal evolution-related gene on chromosome 14).

PLCB3_MOUSE
NC score	0.019325 (rank : 108)	θ value	3.0926 (rank : 106)
Query Neighborhood Hits	126	Target Neighborhood Hits	344	Shared Neighborhood Hits	21
SwissProt Accessions	P51432	Gene names	Plcb3
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta 3 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (Phospholipase C- beta-3) (PLC-beta-3).

RAD50_MOUSE
NC score	0.019188 (rank : 109)	θ value	6.88961 (rank : 115)
Query Neighborhood Hits	126	Target Neighborhood Hits	1366	Shared Neighborhood Hits	30
SwissProt Accessions	P70388, Q6PEB0, Q8C2T7, Q9CU59	Gene names	Rad50
Domain Architecture	No domain graphic available
Description	DNA repair protein RAD50 (EC 3.6.-.-) (mRad50).

ASPD_MOUSE
NC score	0.019143 (rank : 110)	θ value	6.88961 (rank : 113)
Query Neighborhood Hits	126	Target Neighborhood Hits	4	Shared Neighborhood Hits	2
SwissProt Accessions	Q9DCQ2, Q8VCQ0	Gene names
Domain Architecture	No domain graphic available
Description	Putative L-aspartate dehydrogenase (EC 1.4.1.21).

JPH1_MOUSE
NC score	0.018983 (rank : 111)	θ value	0.365318 (rank : 86)
Query Neighborhood Hits	126	Target Neighborhood Hits	120	Shared Neighborhood Hits	3
SwissProt Accessions	Q9ET80, Q9EQZ3	Gene names	Jph1, Jp1
Domain Architecture
Description	Junctophilin-1 (Junctophilin type 1) (JP-1).

ITPR2_HUMAN
NC score	0.018489 (rank : 112)	θ value	0.279714 (rank : 81)
Query Neighborhood Hits	126	Target Neighborhood Hits	74	Shared Neighborhood Hits	4
SwissProt Accessions	Q14571, O94773	Gene names	ITPR2
Domain Architecture
Description	Inositol 1,4,5-trisphosphate receptor type 2 (Type 2 inositol 1,4,5- trisphosphate receptor) (Type 2 InsP3 receptor) (IP3 receptor isoform 2) (InsP3R2).

GOGA3_MOUSE
NC score	0.018212 (rank : 113)	θ value	5.27518 (rank : 111)
Query Neighborhood Hits	126	Target Neighborhood Hits	1437	Shared Neighborhood Hits	26
SwissProt Accessions	P55937, Q80VF5, Q8CCK4, Q9QYT2, Q9QYT3	Gene names	Golga3, Mea2
Domain Architecture
Description	Golgin subfamily A member 3 (Golgin-160) (Male-enhanced antigen 2) (MEA-2).

MY18A_HUMAN
NC score	0.017820 (rank : 114)	θ value	4.03905 (rank : 107)
Query Neighborhood Hits	126	Target Neighborhood Hits	1929	Shared Neighborhood Hits	31
SwissProt Accessions	Q92614, Q8IXP8	Gene names	MYO18A, KIAA0216, MYSPDZ
Domain Architecture
Description	Myosin-18A (Myosin XVIIIa) (Myosin containing PDZ domain) (Molecule associated with JAK3 N-terminus) (MAJN).

RAI14_MOUSE
NC score	0.017776 (rank : 115)	θ value	0.47712 (rank : 92)
Query Neighborhood Hits	126	Target Neighborhood Hits	1505	Shared Neighborhood Hits	27
SwissProt Accessions	Q9EP71, Q3URT3, Q6ZPT6	Gene names	Rai14, Kiaa1334, Norpeg
Domain Architecture	No domain graphic available
Description	Ankycorbin (Ankyrin repeat and coiled-coil structure-containing protein) (Retinoic acid-induced protein 14) (Novel retinal pigment epithelial cell protein) (p125).

CENPC_HUMAN
NC score	0.017577 (rank : 116)	θ value	3.0926 (rank : 104)
Query Neighborhood Hits	126	Target Neighborhood Hits	147	Shared Neighborhood Hits	4
SwissProt Accessions	Q03188, Q9P0M5	Gene names	CENPC1, CENPC, ICEN7
Domain Architecture	No domain graphic available
Description	Centromere protein C 1 (CENP-C) (Centromere autoantigen C) (Interphase centromere complex protein 7).

STX7_MOUSE
NC score	0.017574 (rank : 117)	θ value	1.81305 (rank : 100)
Query Neighborhood Hits	126	Target Neighborhood Hits	131	Shared Neighborhood Hits	10
SwissProt Accessions	O70439	Gene names	Stx7, Syn7
Domain Architecture
Description	Syntaxin-7.

ANR26_HUMAN
NC score	0.017358 (rank : 118)	θ value	5.27518 (rank : 110)
Query Neighborhood Hits	126	Target Neighborhood Hits	1614	Shared Neighborhood Hits	28
SwissProt Accessions	Q9UPS8, Q2TAZ3, Q6ZR14, Q9H1Q1, Q9NSK9, Q9NTD5, Q9NW69	Gene names	ANKRD26, KIAA1074
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 26.

CO3_HUMAN
NC score	0.016691 (rank : 119)	θ value	0.62314 (rank : 95)
Query Neighborhood Hits	126	Target Neighborhood Hits	36	Shared Neighborhood Hits	3
SwissProt Accessions	P01024	Gene names	C3
Domain Architecture
Description	Complement C3 precursor [Contains: Complement C3 beta chain; Complement C3 alpha chain; C3a anaphylatoxin; Complement C3b alpha' chain; Complement C3c fragment; Complement C3dg fragment; Complement C3g fragment; Complement C3d fragment; Complement C3f fragment].

PARG_HUMAN
NC score	0.012600 (rank : 120)	θ value	8.99809 (rank : 125)
Query Neighborhood Hits	126	Target Neighborhood Hits	97	Shared Neighborhood Hits	5
SwissProt Accessions	Q86W56, Q6E4P6, Q6E4P7, Q7Z742, Q9Y4W7	Gene names	PARG
Domain Architecture	No domain graphic available
Description	Poly(ADP-ribose) glycohydrolase (EC 3.2.1.143).

EPIPL_MOUSE
NC score	0.011737 (rank : 121)	θ value	3.0926 (rank : 105)
Query Neighborhood Hits	126	Target Neighborhood Hits	118	Shared Neighborhood Hits	3
SwissProt Accessions	Q8R0W0	Gene names	Eppk1
Domain Architecture
Description	Epiplakin.

TERF1_HUMAN
NC score	0.009905 (rank : 122)	θ value	8.99809 (rank : 126)
Query Neighborhood Hits	126	Target Neighborhood Hits	83	Shared Neighborhood Hits	5
SwissProt Accessions	P54274, Q15553, Q93029	Gene names	TERF1, PIN2, TRF, TRF1
Domain Architecture
Description	Telomeric repeat-binding factor 1 (TTAGGG repeat-binding factor 1) (NIMA-interacting protein 2) (Telomeric protein Pin2/TRF1).

LARP4_MOUSE
NC score	0.007955 (rank : 123)	θ value	8.99809 (rank : 124)
Query Neighborhood Hits	126	Target Neighborhood Hits	260	Shared Neighborhood Hits	4
SwissProt Accessions	Q8BWW4, Q3UR69	Gene names	Larp4
Domain Architecture	No domain graphic available
Description	La-related protein 4 (La ribonucleoprotein domain family member 4).

2A5G_MOUSE
NC score	0.007311 (rank : 124)	θ value	5.27518 (rank : 109)
Query Neighborhood Hits	126	Target Neighborhood Hits	25	Shared Neighborhood Hits	2
SwissProt Accessions	Q60996, O35708, Q99KW8, Q99N67, Q99N68	Gene names	Ppp2r5c
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform (PP2A, B subunit, B' gamma isoform) (PP2A, B subunit, B56 gamma isoform) (PP2A, B subunit, PR61 gamma isoform) (PP2A, B subunit, R5 gamma isoform) (PP2A, B subunit, B'alpha3 isoform).

JHD1B_HUMAN
NC score	0.006159 (rank : 125)	θ value	8.99809 (rank : 122)
Query Neighborhood Hits	126	Target Neighborhood Hits	178	Shared Neighborhood Hits	4
SwissProt Accessions	Q8NHM5, Q8NCI2, Q96HC7, Q96SL0, Q96T03, Q9NS96, Q9UF75	Gene names	FBXL10, CXXC2, FBL10, JHDM1B, PCCX2
Domain Architecture	No domain graphic available
Description	JmjC domain-containing histone demethylation protein 1B (EC 1.14.11.-) (F-box/LRR-repeat protein 10) (F-box and leucine-rich repeat protein 10) (F-box protein FBL10) (Protein JEMMA) (Jumonji domain-containing EMSY-interactor methyltransferase motif protein) (CXXC-type zinc finger protein 2) (Protein-containing CXXC domain 2).

JHD1B_MOUSE
NC score	0.006150 (rank : 126)	θ value	8.99809 (rank : 123)
Query Neighborhood Hits	126	Target Neighborhood Hits	214	Shared Neighborhood Hits	6
SwissProt Accessions	Q6P1G2, Q3V396, Q6PFD0, Q6ZPE8, Q9CSF7, Q9QZN6	Gene names	Fbxl10, Fbl10, Jhdm1b, Kiaa3014
Domain Architecture	No domain graphic available
Description	JmjC domain-containing histone demethylation protein 1B (EC 1.14.11.-) (F-box/LRR-repeat protein 10) (F-box and leucine-rich repeat protein 10) (F-box protein FBL10).

ACOX1_MOUSE
NC score	0.005901 (rank : 127)	θ value	8.99809 (rank : 118)
Query Neighborhood Hits	126	Target Neighborhood Hits	27	Shared Neighborhood Hits	2
SwissProt Accessions	Q9R0H0, O35616, Q3TDG0	Gene names	Acox1, Acox, Paox
Domain Architecture
Description	Acyl-coenzyme A oxidase 1, peroxisomal (EC 1.3.3.6) (Palmitoyl-CoA oxidase) (AOX).

JADE3_HUMAN
NC score	0.004727 (rank : 128)	θ value	6.88961 (rank : 114)
Query Neighborhood Hits	126	Target Neighborhood Hits	148	Shared Neighborhood Hits	4
SwissProt Accessions	Q92613, Q6IE79	Gene names	PHF16, JADE3, KIAA0215
Domain Architecture
Description	Protein Jade-3 (PHD finger protein 16).

CAC1A_HUMAN
NC score	0.000975 (rank : 129)	θ value	8.99809 (rank : 119)
Query Neighborhood Hits	126	Target Neighborhood Hits	387	Shared Neighborhood Hits	2
SwissProt Accessions	O00555, P78510, P78511, Q16290, Q92690, Q99790, Q99791, Q99792, Q99793	Gene names	CACNA1A, CACH4, CACN3, CACNL1A4
Domain Architecture
Description	Voltage-dependent P/Q-type calcium channel subunit alpha-1A (Voltage- gated calcium channel subunit alpha Cav2.1) (Calcium channel, L type, alpha-1 polypeptide isoform 4) (Brain calcium channel I) (BI).

NUAK1_MOUSE
NC score	-0.006541 (rank : 130)	θ value	5.27518 (rank : 112)
Query Neighborhood Hits	126	Target Neighborhood Hits	881	Shared Neighborhood Hits	5
SwissProt Accessions	Q641K5, Q6I6D6, Q8CGE1	Gene names	Nuak1, Kiaa0537
Domain Architecture	No domain graphic available
Description	NUAK family SNF1-like kinase 1 (EC 2.7.11.1).

ZN224_HUMAN
NC score	-0.006677 (rank : 131)	θ value	6.88961 (rank : 117)
Query Neighborhood Hits	126	Target Neighborhood Hits	808	Shared Neighborhood Hits	2
SwissProt Accessions	Q9NZL3, Q86V10, Q8IZC8, Q9UID9, Q9Y2P6	Gene names	ZNF224, BMZF2, ZNF255
Domain Architecture
Description	Zinc finger protein 224 (Zinc finger protein 255) (Bone marrow zinc finger 2) (BMZF-2).