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Network neighborhood for query Sequence : UBA3_HUMAN

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UBA3_HUMAN
SwissProt Accessions	Q8TBC4, O76088, Q9NTU3	Gene names	UBE1C, UBA3
Domain Architecture	No domain graphic available
Description	NEDD8-activating enzyme E1 catalytic subunit (EC 6.3.2.-) (Ubiquitin- activating enzyme 3) (NEDD8-activating enzyme E1C) (Ubiquitin- activating enzyme E1C).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

UBA3_HUMAN
θ value	0 (rank : 1)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	22	Target Neighborhood Hits	22	Shared Neighborhood Hits	22
SwissProt Accessions	Q8TBC4, O76088, Q9NTU3	Gene names	UBE1C, UBA3
Domain Architecture	No domain graphic available
Description	NEDD8-activating enzyme E1 catalytic subunit (EC 6.3.2.-) (Ubiquitin- activating enzyme 3) (NEDD8-activating enzyme E1C) (Ubiquitin- activating enzyme E1C).

UBA3_MOUSE
θ value	0 (rank : 2)	NC score	0.999956 (rank : 2)
Query Neighborhood Hits	22	Target Neighborhood Hits	22	Shared Neighborhood Hits	22
SwissProt Accessions	Q8C878, O88598, Q9D6B7	Gene names	Ube1c, Uba3
Domain Architecture	No domain graphic available
Description	NEDD8-activating enzyme E1 catalytic subunit (EC 6.3.2.-) (Ubiquitin- activating enzyme 3) (NEDD8-activating enzyme E1C) (Ubiquitin- activating enzyme E1C).

ULE1B_HUMAN
θ value	2.58786e-39 (rank : 3)	NC score	0.830515 (rank : 3)
Query Neighborhood Hits	22	Target Neighborhood Hits	31	Shared Neighborhood Hits	16
SwissProt Accessions	Q9UBT2, O95605, Q9NTJ1, Q9UED2	Gene names	UBLE1B, SAE2, UBA2
Domain Architecture
Description	Ubiquitin-like 1-activating enzyme E1B (SUMO-1-activating enzyme subunit 2) (Anthracycline-associated resistance ARX).

ULE1B_MOUSE
θ value	4.41421e-39 (rank : 4)	NC score	0.826839 (rank : 4)
Query Neighborhood Hits	22	Target Neighborhood Hits	56	Shared Neighborhood Hits	16
SwissProt Accessions	Q9Z1F9, Q8BVX9	Gene names	Uble1b, Sae2, Uba2
Domain Architecture
Description	Ubiquitin-like 1-activating enzyme E1B (SUMO-1-activating enzyme subunit 2) (Anthracycline-associated resistance ARX).

UBE1_HUMAN
θ value	3.28125e-26 (rank : 5)	NC score	0.722289 (rank : 6)
Query Neighborhood Hits	22	Target Neighborhood Hits	19	Shared Neighborhood Hits	14
SwissProt Accessions	P22314, Q96E13	Gene names	UBE1
Domain Architecture
Description	Ubiquitin-activating enzyme E1 (A1S9 protein).

UBE1_MOUSE
θ value	1.62847e-25 (rank : 6)	NC score	0.719818 (rank : 7)
Query Neighborhood Hits	22	Target Neighborhood Hits	21	Shared Neighborhood Hits	14
SwissProt Accessions	Q02053, Q542H8	Gene names	Ube1x, Uba1, Ube1
Domain Architecture
Description	Ubiquitin-activating enzyme E1 1.

UBE1L_HUMAN
θ value	5.79196e-23 (rank : 7)	NC score	0.723858 (rank : 5)
Query Neighborhood Hits	22	Target Neighborhood Hits	26	Shared Neighborhood Hits	16
SwissProt Accessions	P41226	Gene names	UBE1L, UBE2
Domain Architecture
Description	Ubiquitin-activating enzyme E1 homolog (D8).

MOCS3_HUMAN
θ value	5.26297e-08 (rank : 8)	NC score	0.609670 (rank : 8)
Query Neighborhood Hits	22	Target Neighborhood Hits	20	Shared Neighborhood Hits	16
SwissProt Accessions	O95396	Gene names	MOCS3
Domain Architecture
Description	Molybdenum cofactor synthesis protein 3 (Molybdopterin synthase sulfurylase) (MPT synthase sulfurylase).

ULE1A_HUMAN
θ value	1.17247e-07 (rank : 9)	NC score	0.565151 (rank : 9)
Query Neighborhood Hits	22	Target Neighborhood Hits	18	Shared Neighborhood Hits	16
SwissProt Accessions	Q9UBE0, O95717, Q9P020	Gene names	UBLE1A, AOS1, SAE1, SUA1
Domain Architecture
Description	Ubiquitin-like 1-activating enzyme E1A (SUMO-1-activating enzyme subunit 1).

ULE1A_MOUSE
θ value	4.45536e-07 (rank : 10)	NC score	0.552154 (rank : 10)
Query Neighborhood Hits	22	Target Neighborhood Hits	14	Shared Neighborhood Hits	14
SwissProt Accessions	Q9R1T2, Q3TWJ0, Q9CSW9	Gene names	Uble1a, Aos1, Sae1, Sua1, Ubl1a1
Domain Architecture
Description	Ubiquitin-like 1-activating enzyme E1A (SUMO-1-activating enzyme subunit 1).

ULA1_MOUSE
θ value	1.69304e-06 (rank : 11)	NC score	0.459511 (rank : 11)
Query Neighborhood Hits	22	Target Neighborhood Hits	22	Shared Neighborhood Hits	13
SwissProt Accessions	Q8VBW6, Q8CFL6	Gene names	Appbp1
Domain Architecture	No domain graphic available
Description	NEDD8-activating enzyme E1 regulatory subunit (Amyloid protein-binding protein 1) (Amyloid beta precursor protein-binding protein 1, 59 kDa) (APP-BP1).

ULA1_HUMAN
θ value	1.09739e-05 (rank : 12)	NC score	0.451422 (rank : 12)
Query Neighborhood Hits	22	Target Neighborhood Hits	18	Shared Neighborhood Hits	13
SwissProt Accessions	Q13564	Gene names	APPBP1
Domain Architecture	No domain graphic available
Description	NEDD8-activating enzyme E1 regulatory subunit (Amyloid protein-binding protein 1) (Amyloid beta precursor protein-binding protein 1, 59 kDa) (APP-BP1) (Protooncogene protein 1) (HPP1).

UE1D1_MOUSE
θ value	4.1701e-05 (rank : 13)	NC score	0.412251 (rank : 14)
Query Neighborhood Hits	22	Target Neighborhood Hits	16	Shared Neighborhood Hits	12
SwissProt Accessions	Q8VE47, Q9CYD6	Gene names	Ube1dc1
Domain Architecture	No domain graphic available
Description	Ubiquitin-activating enzyme E1 domain-containing protein 1 (UFM1- activating enzyme).

UE1D1_HUMAN
θ value	7.1131e-05 (rank : 14)	NC score	0.413505 (rank : 13)
Query Neighborhood Hits	22	Target Neighborhood Hits	19	Shared Neighborhood Hits	14
SwissProt Accessions	Q9GZZ9, Q96ST1	Gene names	UBE1DC1, UBA5
Domain Architecture	No domain graphic available
Description	Ubiquitin-activating enzyme E1 domain-containing protein 1 (UFM1- activating enzyme) (Ubiquitin-activating enzyme 5) (ThiFP1).

ATG7_MOUSE
θ value	0.000158464 (rank : 15)	NC score	0.256600 (rank : 15)
Query Neighborhood Hits	22	Target Neighborhood Hits	16	Shared Neighborhood Hits	9
SwissProt Accessions	Q9D906, Q3TCD9, Q8K4Q5	Gene names	Atg7, Apg7l
Domain Architecture	No domain graphic available
Description	Autophagy-related protein 7 (APG7-like) (Ubiquitin-activating enzyme E1-like protein) (mAGP7).

ATG7_HUMAN
θ value	0.000270298 (rank : 16)	NC score	0.253286 (rank : 16)
Query Neighborhood Hits	22	Target Neighborhood Hits	14	Shared Neighborhood Hits	9
SwissProt Accessions	O95352, Q7L8L0, Q9BWP2, Q9UFH4	Gene names	ATG7, APG7L
Domain Architecture	No domain graphic available
Description	Autophagy-related protein 7 (APG7-like) (Ubiquitin-activating enzyme E1-like protein) (hAGP7).

UBP16_HUMAN
θ value	2.36792 (rank : 17)	NC score	0.024124 (rank : 18)
Query Neighborhood Hits	22	Target Neighborhood Hits	126	Shared Neighborhood Hits	3
SwissProt Accessions	Q9Y5T5, Q8NEL3	Gene names	USP16
Domain Architecture
Description	Ubiquitin carboxyl-terminal hydrolase 16 (EC 3.1.2.15) (Ubiquitin thioesterase 16) (Ubiquitin-specific-processing protease 16) (Deubiquitinating enzyme 16) (Ubiquitin-processing protease UBP-M).

DPOG2_HUMAN
θ value	3.0926 (rank : 18)	NC score	0.037108 (rank : 17)
Query Neighborhood Hits	22	Target Neighborhood Hits	12	Shared Neighborhood Hits	3
SwissProt Accessions	Q9UHN1, O00419, Q9UK35, Q9UK94	Gene names	POLG2, MTPOLB
Domain Architecture
Description	DNA polymerase subunit gamma 2, mitochondrial precursor (EC 2.7.7.7) (Mitochondrial DNA polymerase accessory subunit) (PolG-beta) (MtPolB) (DNA polymerase gamma accessory 55 kDa subunit) (p55).

DMPK_MOUSE
θ value	5.27518 (rank : 19)	NC score	0.001355 (rank : 22)
Query Neighborhood Hits	22	Target Neighborhood Hits	908	Shared Neighborhood Hits	3
SwissProt Accessions	P54265	Gene names	Dmpk, Dm15, Mdpk
Domain Architecture
Description	Myotonin-protein kinase (EC 2.7.11.1) (Myotonic dystrophy protein kinase) (MDPK) (DM-kinase) (DMK) (DMPK) (MT-PK).

TOP1_MOUSE
θ value	5.27518 (rank : 20)	NC score	0.019742 (rank : 19)
Query Neighborhood Hits	22	Target Neighborhood Hits	213	Shared Neighborhood Hits	3
SwissProt Accessions	Q04750	Gene names	Top1, Top-1
Domain Architecture
Description	DNA topoisomerase 1 (EC 5.99.1.2) (DNA topoisomerase I).

SARDH_MOUSE
θ value	8.99809 (rank : 21)	NC score	0.013754 (rank : 21)
Query Neighborhood Hits	22	Target Neighborhood Hits	26	Shared Neighborhood Hits	3
SwissProt Accessions	Q99LB7	Gene names	Sardh
Domain Architecture	No domain graphic available
Description	Sarcosine dehydrogenase, mitochondrial precursor (EC 1.5.99.1) (SarDH).

TNAP3_HUMAN
θ value	8.99809 (rank : 22)	NC score	0.014170 (rank : 20)
Query Neighborhood Hits	22	Target Neighborhood Hits	58	Shared Neighborhood Hits	3
SwissProt Accessions	P21580, Q5VXQ7, Q9NSR6	Gene names	TNFAIP3
Domain Architecture
Description	Tumor necrosis factor, alpha-induced protein 3 (EC 3.-.-.-) (Putative DNA-binding protein A20) (Zinc finger protein A20).

Hits sorted by NC score

UBA3_HUMAN
NC score	0.999962 (rank : 1)	θ value	0 (rank : 1)
Query Neighborhood Hits	22	Target Neighborhood Hits	22	Shared Neighborhood Hits	22
SwissProt Accessions	Q8TBC4, O76088, Q9NTU3	Gene names	UBE1C, UBA3
Domain Architecture	No domain graphic available
Description	NEDD8-activating enzyme E1 catalytic subunit (EC 6.3.2.-) (Ubiquitin- activating enzyme 3) (NEDD8-activating enzyme E1C) (Ubiquitin- activating enzyme E1C).

UBA3_MOUSE
NC score	0.999956 (rank : 2)	θ value	0 (rank : 2)
Query Neighborhood Hits	22	Target Neighborhood Hits	22	Shared Neighborhood Hits	22
SwissProt Accessions	Q8C878, O88598, Q9D6B7	Gene names	Ube1c, Uba3
Domain Architecture	No domain graphic available
Description	NEDD8-activating enzyme E1 catalytic subunit (EC 6.3.2.-) (Ubiquitin- activating enzyme 3) (NEDD8-activating enzyme E1C) (Ubiquitin- activating enzyme E1C).

ULE1B_HUMAN
NC score	0.830515 (rank : 3)	θ value	2.58786e-39 (rank : 3)
Query Neighborhood Hits	22	Target Neighborhood Hits	31	Shared Neighborhood Hits	16
SwissProt Accessions	Q9UBT2, O95605, Q9NTJ1, Q9UED2	Gene names	UBLE1B, SAE2, UBA2
Domain Architecture
Description	Ubiquitin-like 1-activating enzyme E1B (SUMO-1-activating enzyme subunit 2) (Anthracycline-associated resistance ARX).

ULE1B_MOUSE
NC score	0.826839 (rank : 4)	θ value	4.41421e-39 (rank : 4)
Query Neighborhood Hits	22	Target Neighborhood Hits	56	Shared Neighborhood Hits	16
SwissProt Accessions	Q9Z1F9, Q8BVX9	Gene names	Uble1b, Sae2, Uba2
Domain Architecture
Description	Ubiquitin-like 1-activating enzyme E1B (SUMO-1-activating enzyme subunit 2) (Anthracycline-associated resistance ARX).

UBE1L_HUMAN
NC score	0.723858 (rank : 5)	θ value	5.79196e-23 (rank : 7)
Query Neighborhood Hits	22	Target Neighborhood Hits	26	Shared Neighborhood Hits	16
SwissProt Accessions	P41226	Gene names	UBE1L, UBE2
Domain Architecture
Description	Ubiquitin-activating enzyme E1 homolog (D8).

UBE1_HUMAN
NC score	0.722289 (rank : 6)	θ value	3.28125e-26 (rank : 5)
Query Neighborhood Hits	22	Target Neighborhood Hits	19	Shared Neighborhood Hits	14
SwissProt Accessions	P22314, Q96E13	Gene names	UBE1
Domain Architecture
Description	Ubiquitin-activating enzyme E1 (A1S9 protein).

UBE1_MOUSE
NC score	0.719818 (rank : 7)	θ value	1.62847e-25 (rank : 6)
Query Neighborhood Hits	22	Target Neighborhood Hits	21	Shared Neighborhood Hits	14
SwissProt Accessions	Q02053, Q542H8	Gene names	Ube1x, Uba1, Ube1
Domain Architecture
Description	Ubiquitin-activating enzyme E1 1.

MOCS3_HUMAN
NC score	0.609670 (rank : 8)	θ value	5.26297e-08 (rank : 8)
Query Neighborhood Hits	22	Target Neighborhood Hits	20	Shared Neighborhood Hits	16
SwissProt Accessions	O95396	Gene names	MOCS3
Domain Architecture
Description	Molybdenum cofactor synthesis protein 3 (Molybdopterin synthase sulfurylase) (MPT synthase sulfurylase).

ULE1A_HUMAN
NC score	0.565151 (rank : 9)	θ value	1.17247e-07 (rank : 9)
Query Neighborhood Hits	22	Target Neighborhood Hits	18	Shared Neighborhood Hits	16
SwissProt Accessions	Q9UBE0, O95717, Q9P020	Gene names	UBLE1A, AOS1, SAE1, SUA1
Domain Architecture
Description	Ubiquitin-like 1-activating enzyme E1A (SUMO-1-activating enzyme subunit 1).

ULE1A_MOUSE
NC score	0.552154 (rank : 10)	θ value	4.45536e-07 (rank : 10)
Query Neighborhood Hits	22	Target Neighborhood Hits	14	Shared Neighborhood Hits	14
SwissProt Accessions	Q9R1T2, Q3TWJ0, Q9CSW9	Gene names	Uble1a, Aos1, Sae1, Sua1, Ubl1a1
Domain Architecture
Description	Ubiquitin-like 1-activating enzyme E1A (SUMO-1-activating enzyme subunit 1).

ULA1_MOUSE
NC score	0.459511 (rank : 11)	θ value	1.69304e-06 (rank : 11)
Query Neighborhood Hits	22	Target Neighborhood Hits	22	Shared Neighborhood Hits	13
SwissProt Accessions	Q8VBW6, Q8CFL6	Gene names	Appbp1
Domain Architecture	No domain graphic available
Description	NEDD8-activating enzyme E1 regulatory subunit (Amyloid protein-binding protein 1) (Amyloid beta precursor protein-binding protein 1, 59 kDa) (APP-BP1).

ULA1_HUMAN
NC score	0.451422 (rank : 12)	θ value	1.09739e-05 (rank : 12)
Query Neighborhood Hits	22	Target Neighborhood Hits	18	Shared Neighborhood Hits	13
SwissProt Accessions	Q13564	Gene names	APPBP1
Domain Architecture	No domain graphic available
Description	NEDD8-activating enzyme E1 regulatory subunit (Amyloid protein-binding protein 1) (Amyloid beta precursor protein-binding protein 1, 59 kDa) (APP-BP1) (Protooncogene protein 1) (HPP1).

UE1D1_HUMAN
NC score	0.413505 (rank : 13)	θ value	7.1131e-05 (rank : 14)
Query Neighborhood Hits	22	Target Neighborhood Hits	19	Shared Neighborhood Hits	14
SwissProt Accessions	Q9GZZ9, Q96ST1	Gene names	UBE1DC1, UBA5
Domain Architecture	No domain graphic available
Description	Ubiquitin-activating enzyme E1 domain-containing protein 1 (UFM1- activating enzyme) (Ubiquitin-activating enzyme 5) (ThiFP1).

UE1D1_MOUSE
NC score	0.412251 (rank : 14)	θ value	4.1701e-05 (rank : 13)
Query Neighborhood Hits	22	Target Neighborhood Hits	16	Shared Neighborhood Hits	12
SwissProt Accessions	Q8VE47, Q9CYD6	Gene names	Ube1dc1
Domain Architecture	No domain graphic available
Description	Ubiquitin-activating enzyme E1 domain-containing protein 1 (UFM1- activating enzyme).

ATG7_MOUSE
NC score	0.256600 (rank : 15)	θ value	0.000158464 (rank : 15)
Query Neighborhood Hits	22	Target Neighborhood Hits	16	Shared Neighborhood Hits	9
SwissProt Accessions	Q9D906, Q3TCD9, Q8K4Q5	Gene names	Atg7, Apg7l
Domain Architecture	No domain graphic available
Description	Autophagy-related protein 7 (APG7-like) (Ubiquitin-activating enzyme E1-like protein) (mAGP7).

ATG7_HUMAN
NC score	0.253286 (rank : 16)	θ value	0.000270298 (rank : 16)
Query Neighborhood Hits	22	Target Neighborhood Hits	14	Shared Neighborhood Hits	9
SwissProt Accessions	O95352, Q7L8L0, Q9BWP2, Q9UFH4	Gene names	ATG7, APG7L
Domain Architecture	No domain graphic available
Description	Autophagy-related protein 7 (APG7-like) (Ubiquitin-activating enzyme E1-like protein) (hAGP7).

DPOG2_HUMAN
NC score	0.037108 (rank : 17)	θ value	3.0926 (rank : 18)
Query Neighborhood Hits	22	Target Neighborhood Hits	12	Shared Neighborhood Hits	3
SwissProt Accessions	Q9UHN1, O00419, Q9UK35, Q9UK94	Gene names	POLG2, MTPOLB
Domain Architecture
Description	DNA polymerase subunit gamma 2, mitochondrial precursor (EC 2.7.7.7) (Mitochondrial DNA polymerase accessory subunit) (PolG-beta) (MtPolB) (DNA polymerase gamma accessory 55 kDa subunit) (p55).

UBP16_HUMAN
NC score	0.024124 (rank : 18)	θ value	2.36792 (rank : 17)
Query Neighborhood Hits	22	Target Neighborhood Hits	126	Shared Neighborhood Hits	3
SwissProt Accessions	Q9Y5T5, Q8NEL3	Gene names	USP16
Domain Architecture
Description	Ubiquitin carboxyl-terminal hydrolase 16 (EC 3.1.2.15) (Ubiquitin thioesterase 16) (Ubiquitin-specific-processing protease 16) (Deubiquitinating enzyme 16) (Ubiquitin-processing protease UBP-M).

TOP1_MOUSE
NC score	0.019742 (rank : 19)	θ value	5.27518 (rank : 20)
Query Neighborhood Hits	22	Target Neighborhood Hits	213	Shared Neighborhood Hits	3
SwissProt Accessions	Q04750	Gene names	Top1, Top-1
Domain Architecture
Description	DNA topoisomerase 1 (EC 5.99.1.2) (DNA topoisomerase I).

TNAP3_HUMAN
NC score	0.014170 (rank : 20)	θ value	8.99809 (rank : 22)
Query Neighborhood Hits	22	Target Neighborhood Hits	58	Shared Neighborhood Hits	3
SwissProt Accessions	P21580, Q5VXQ7, Q9NSR6	Gene names	TNFAIP3
Domain Architecture
Description	Tumor necrosis factor, alpha-induced protein 3 (EC 3.-.-.-) (Putative DNA-binding protein A20) (Zinc finger protein A20).

SARDH_MOUSE
NC score	0.013754 (rank : 21)	θ value	8.99809 (rank : 21)
Query Neighborhood Hits	22	Target Neighborhood Hits	26	Shared Neighborhood Hits	3
SwissProt Accessions	Q99LB7	Gene names	Sardh
Domain Architecture	No domain graphic available
Description	Sarcosine dehydrogenase, mitochondrial precursor (EC 1.5.99.1) (SarDH).

DMPK_MOUSE
NC score	0.001355 (rank : 22)	θ value	5.27518 (rank : 19)
Query Neighborhood Hits	22	Target Neighborhood Hits	908	Shared Neighborhood Hits	3
SwissProt Accessions	P54265	Gene names	Dmpk, Dm15, Mdpk
Domain Architecture
Description	Myotonin-protein kinase (EC 2.7.11.1) (Myotonic dystrophy protein kinase) (MDPK) (DM-kinase) (DMK) (DMPK) (MT-PK).