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Network neighborhood for query Sequence : ULE1A_HUMAN

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ULE1A_HUMAN
SwissProt Accessions	Q9UBE0, O95717, Q9P020	Gene names	UBLE1A, AOS1, SAE1, SUA1
Domain Architecture
Description	Ubiquitin-like 1-activating enzyme E1A (SUMO-1-activating enzyme subunit 1).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

ULE1A_HUMAN
θ value	0 (rank : 1)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	18	Target Neighborhood Hits	18	Shared Neighborhood Hits	18
SwissProt Accessions	Q9UBE0, O95717, Q9P020	Gene names	UBLE1A, AOS1, SAE1, SUA1
Domain Architecture
Description	Ubiquitin-like 1-activating enzyme E1A (SUMO-1-activating enzyme subunit 1).

ULE1A_MOUSE
θ value	3.35459e-180 (rank : 2)	NC score	0.997267 (rank : 2)
Query Neighborhood Hits	18	Target Neighborhood Hits	14	Shared Neighborhood Hits	14
SwissProt Accessions	Q9R1T2, Q3TWJ0, Q9CSW9	Gene names	Uble1a, Aos1, Sae1, Sua1, Ubl1a1
Domain Architecture
Description	Ubiquitin-like 1-activating enzyme E1A (SUMO-1-activating enzyme subunit 1).

UBE1_HUMAN
θ value	2.27234e-27 (rank : 3)	NC score	0.742002 (rank : 4)
Query Neighborhood Hits	18	Target Neighborhood Hits	19	Shared Neighborhood Hits	14
SwissProt Accessions	P22314, Q96E13	Gene names	UBE1
Domain Architecture
Description	Ubiquitin-activating enzyme E1 (A1S9 protein).

UBE1_MOUSE
θ value	1.37858e-24 (rank : 4)	NC score	0.732750 (rank : 5)
Query Neighborhood Hits	18	Target Neighborhood Hits	21	Shared Neighborhood Hits	14
SwissProt Accessions	Q02053, Q542H8	Gene names	Ube1x, Uba1, Ube1
Domain Architecture
Description	Ubiquitin-activating enzyme E1 1.

UBE1L_HUMAN
θ value	2.35151e-24 (rank : 5)	NC score	0.749358 (rank : 3)
Query Neighborhood Hits	18	Target Neighborhood Hits	26	Shared Neighborhood Hits	16
SwissProt Accessions	P41226	Gene names	UBE1L, UBE2
Domain Architecture
Description	Ubiquitin-activating enzyme E1 homolog (D8).

ULA1_HUMAN
θ value	5.42112e-21 (rank : 6)	NC score	0.712213 (rank : 6)
Query Neighborhood Hits	18	Target Neighborhood Hits	18	Shared Neighborhood Hits	13
SwissProt Accessions	Q13564	Gene names	APPBP1
Domain Architecture	No domain graphic available
Description	NEDD8-activating enzyme E1 regulatory subunit (Amyloid protein-binding protein 1) (Amyloid beta precursor protein-binding protein 1, 59 kDa) (APP-BP1) (Protooncogene protein 1) (HPP1).

ULA1_MOUSE
θ value	2.69047e-20 (rank : 7)	NC score	0.705935 (rank : 7)
Query Neighborhood Hits	18	Target Neighborhood Hits	22	Shared Neighborhood Hits	13
SwissProt Accessions	Q8VBW6, Q8CFL6	Gene names	Appbp1
Domain Architecture	No domain graphic available
Description	NEDD8-activating enzyme E1 regulatory subunit (Amyloid protein-binding protein 1) (Amyloid beta precursor protein-binding protein 1, 59 kDa) (APP-BP1).

ULE1B_MOUSE
θ value	4.76016e-09 (rank : 8)	NC score	0.572730 (rank : 8)
Query Neighborhood Hits	18	Target Neighborhood Hits	56	Shared Neighborhood Hits	16
SwissProt Accessions	Q9Z1F9, Q8BVX9	Gene names	Uble1b, Sae2, Uba2
Domain Architecture
Description	Ubiquitin-like 1-activating enzyme E1B (SUMO-1-activating enzyme subunit 2) (Anthracycline-associated resistance ARX).

ULE1B_HUMAN
θ value	3.08544e-08 (rank : 9)	NC score	0.559723 (rank : 11)
Query Neighborhood Hits	18	Target Neighborhood Hits	31	Shared Neighborhood Hits	16
SwissProt Accessions	Q9UBT2, O95605, Q9NTJ1, Q9UED2	Gene names	UBLE1B, SAE2, UBA2
Domain Architecture
Description	Ubiquitin-like 1-activating enzyme E1B (SUMO-1-activating enzyme subunit 2) (Anthracycline-associated resistance ARX).

UBA3_MOUSE
θ value	8.97725e-08 (rank : 10)	NC score	0.566317 (rank : 9)
Query Neighborhood Hits	18	Target Neighborhood Hits	22	Shared Neighborhood Hits	16
SwissProt Accessions	Q8C878, O88598, Q9D6B7	Gene names	Ube1c, Uba3
Domain Architecture	No domain graphic available
Description	NEDD8-activating enzyme E1 catalytic subunit (EC 6.3.2.-) (Ubiquitin- activating enzyme 3) (NEDD8-activating enzyme E1C) (Ubiquitin- activating enzyme E1C).

UBA3_HUMAN
θ value	1.17247e-07 (rank : 11)	NC score	0.565151 (rank : 10)
Query Neighborhood Hits	18	Target Neighborhood Hits	22	Shared Neighborhood Hits	16
SwissProt Accessions	Q8TBC4, O76088, Q9NTU3	Gene names	UBE1C, UBA3
Domain Architecture	No domain graphic available
Description	NEDD8-activating enzyme E1 catalytic subunit (EC 6.3.2.-) (Ubiquitin- activating enzyme 3) (NEDD8-activating enzyme E1C) (Ubiquitin- activating enzyme E1C).

MOCS3_HUMAN
θ value	0.000461057 (rank : 12)	NC score	0.486844 (rank : 12)
Query Neighborhood Hits	18	Target Neighborhood Hits	20	Shared Neighborhood Hits	16
SwissProt Accessions	O95396	Gene names	MOCS3
Domain Architecture
Description	Molybdenum cofactor synthesis protein 3 (Molybdopterin synthase sulfurylase) (MPT synthase sulfurylase).

ATG7_HUMAN
θ value	0.0563607 (rank : 13)	NC score	0.140630 (rank : 15)
Query Neighborhood Hits	18	Target Neighborhood Hits	14	Shared Neighborhood Hits	9
SwissProt Accessions	O95352, Q7L8L0, Q9BWP2, Q9UFH4	Gene names	ATG7, APG7L
Domain Architecture	No domain graphic available
Description	Autophagy-related protein 7 (APG7-like) (Ubiquitin-activating enzyme E1-like protein) (hAGP7).

ATG7_MOUSE
θ value	0.21417 (rank : 14)	NC score	0.135933 (rank : 16)
Query Neighborhood Hits	18	Target Neighborhood Hits	16	Shared Neighborhood Hits	9
SwissProt Accessions	Q9D906, Q3TCD9, Q8K4Q5	Gene names	Atg7, Apg7l
Domain Architecture	No domain graphic available
Description	Autophagy-related protein 7 (APG7-like) (Ubiquitin-activating enzyme E1-like protein) (mAGP7).

UE1D1_MOUSE
θ value	0.21417 (rank : 15)	NC score	0.270224 (rank : 14)
Query Neighborhood Hits	18	Target Neighborhood Hits	16	Shared Neighborhood Hits	12
SwissProt Accessions	Q8VE47, Q9CYD6	Gene names	Ube1dc1
Domain Architecture	No domain graphic available
Description	Ubiquitin-activating enzyme E1 domain-containing protein 1 (UFM1- activating enzyme).

UE1D1_HUMAN
θ value	0.279714 (rank : 16)	NC score	0.275732 (rank : 13)
Query Neighborhood Hits	18	Target Neighborhood Hits	19	Shared Neighborhood Hits	14
SwissProt Accessions	Q9GZZ9, Q96ST1	Gene names	UBE1DC1, UBA5
Domain Architecture	No domain graphic available
Description	Ubiquitin-activating enzyme E1 domain-containing protein 1 (UFM1- activating enzyme) (Ubiquitin-activating enzyme 5) (ThiFP1).

RAE1_MOUSE
θ value	1.38821 (rank : 17)	NC score	0.022890 (rank : 17)
Query Neighborhood Hits	18	Target Neighborhood Hits	32	Shared Neighborhood Hits	2
SwissProt Accessions	Q9QXG2, Q80UV8	Gene names	Chm, Rep1
Domain Architecture
Description	Rab proteins geranylgeranyltransferase component A 1 (Rab escort protein 1) (REP-1) (Choroideraemia protein homolog).

BBX_MOUSE
θ value	6.88961 (rank : 18)	NC score	0.010580 (rank : 18)
Query Neighborhood Hits	18	Target Neighborhood Hits	152	Shared Neighborhood Hits	2
SwissProt Accessions	Q8VBW5, Q3TZK1, Q6NXY8, Q6PEU3, Q8BQJ7, Q8C7E0, Q8CDQ0, Q8CDV1, Q8VI48, Q8VI49, Q8VI50, Q9CS94	Gene names	Bbx, Hbp2
Domain Architecture	No domain graphic available
Description	HMG box transcription factor BBX (Bobby sox homolog) (HMG box- containing protein 2).

Hits sorted by NC score

ULE1A_HUMAN
NC score	0.999962 (rank : 1)	θ value	0 (rank : 1)
Query Neighborhood Hits	18	Target Neighborhood Hits	18	Shared Neighborhood Hits	18
SwissProt Accessions	Q9UBE0, O95717, Q9P020	Gene names	UBLE1A, AOS1, SAE1, SUA1
Domain Architecture
Description	Ubiquitin-like 1-activating enzyme E1A (SUMO-1-activating enzyme subunit 1).

ULE1A_MOUSE
NC score	0.997267 (rank : 2)	θ value	3.35459e-180 (rank : 2)
Query Neighborhood Hits	18	Target Neighborhood Hits	14	Shared Neighborhood Hits	14
SwissProt Accessions	Q9R1T2, Q3TWJ0, Q9CSW9	Gene names	Uble1a, Aos1, Sae1, Sua1, Ubl1a1
Domain Architecture
Description	Ubiquitin-like 1-activating enzyme E1A (SUMO-1-activating enzyme subunit 1).

UBE1L_HUMAN
NC score	0.749358 (rank : 3)	θ value	2.35151e-24 (rank : 5)
Query Neighborhood Hits	18	Target Neighborhood Hits	26	Shared Neighborhood Hits	16
SwissProt Accessions	P41226	Gene names	UBE1L, UBE2
Domain Architecture
Description	Ubiquitin-activating enzyme E1 homolog (D8).

UBE1_HUMAN
NC score	0.742002 (rank : 4)	θ value	2.27234e-27 (rank : 3)
Query Neighborhood Hits	18	Target Neighborhood Hits	19	Shared Neighborhood Hits	14
SwissProt Accessions	P22314, Q96E13	Gene names	UBE1
Domain Architecture
Description	Ubiquitin-activating enzyme E1 (A1S9 protein).

UBE1_MOUSE
NC score	0.732750 (rank : 5)	θ value	1.37858e-24 (rank : 4)
Query Neighborhood Hits	18	Target Neighborhood Hits	21	Shared Neighborhood Hits	14
SwissProt Accessions	Q02053, Q542H8	Gene names	Ube1x, Uba1, Ube1
Domain Architecture
Description	Ubiquitin-activating enzyme E1 1.

ULA1_HUMAN
NC score	0.712213 (rank : 6)	θ value	5.42112e-21 (rank : 6)
Query Neighborhood Hits	18	Target Neighborhood Hits	18	Shared Neighborhood Hits	13
SwissProt Accessions	Q13564	Gene names	APPBP1
Domain Architecture	No domain graphic available
Description	NEDD8-activating enzyme E1 regulatory subunit (Amyloid protein-binding protein 1) (Amyloid beta precursor protein-binding protein 1, 59 kDa) (APP-BP1) (Protooncogene protein 1) (HPP1).

ULA1_MOUSE
NC score	0.705935 (rank : 7)	θ value	2.69047e-20 (rank : 7)
Query Neighborhood Hits	18	Target Neighborhood Hits	22	Shared Neighborhood Hits	13
SwissProt Accessions	Q8VBW6, Q8CFL6	Gene names	Appbp1
Domain Architecture	No domain graphic available
Description	NEDD8-activating enzyme E1 regulatory subunit (Amyloid protein-binding protein 1) (Amyloid beta precursor protein-binding protein 1, 59 kDa) (APP-BP1).

ULE1B_MOUSE
NC score	0.572730 (rank : 8)	θ value	4.76016e-09 (rank : 8)
Query Neighborhood Hits	18	Target Neighborhood Hits	56	Shared Neighborhood Hits	16
SwissProt Accessions	Q9Z1F9, Q8BVX9	Gene names	Uble1b, Sae2, Uba2
Domain Architecture
Description	Ubiquitin-like 1-activating enzyme E1B (SUMO-1-activating enzyme subunit 2) (Anthracycline-associated resistance ARX).

UBA3_MOUSE
NC score	0.566317 (rank : 9)	θ value	8.97725e-08 (rank : 10)
Query Neighborhood Hits	18	Target Neighborhood Hits	22	Shared Neighborhood Hits	16
SwissProt Accessions	Q8C878, O88598, Q9D6B7	Gene names	Ube1c, Uba3
Domain Architecture	No domain graphic available
Description	NEDD8-activating enzyme E1 catalytic subunit (EC 6.3.2.-) (Ubiquitin- activating enzyme 3) (NEDD8-activating enzyme E1C) (Ubiquitin- activating enzyme E1C).

UBA3_HUMAN
NC score	0.565151 (rank : 10)	θ value	1.17247e-07 (rank : 11)
Query Neighborhood Hits	18	Target Neighborhood Hits	22	Shared Neighborhood Hits	16
SwissProt Accessions	Q8TBC4, O76088, Q9NTU3	Gene names	UBE1C, UBA3
Domain Architecture	No domain graphic available
Description	NEDD8-activating enzyme E1 catalytic subunit (EC 6.3.2.-) (Ubiquitin- activating enzyme 3) (NEDD8-activating enzyme E1C) (Ubiquitin- activating enzyme E1C).

ULE1B_HUMAN
NC score	0.559723 (rank : 11)	θ value	3.08544e-08 (rank : 9)
Query Neighborhood Hits	18	Target Neighborhood Hits	31	Shared Neighborhood Hits	16
SwissProt Accessions	Q9UBT2, O95605, Q9NTJ1, Q9UED2	Gene names	UBLE1B, SAE2, UBA2
Domain Architecture
Description	Ubiquitin-like 1-activating enzyme E1B (SUMO-1-activating enzyme subunit 2) (Anthracycline-associated resistance ARX).

MOCS3_HUMAN
NC score	0.486844 (rank : 12)	θ value	0.000461057 (rank : 12)
Query Neighborhood Hits	18	Target Neighborhood Hits	20	Shared Neighborhood Hits	16
SwissProt Accessions	O95396	Gene names	MOCS3
Domain Architecture
Description	Molybdenum cofactor synthesis protein 3 (Molybdopterin synthase sulfurylase) (MPT synthase sulfurylase).

UE1D1_HUMAN
NC score	0.275732 (rank : 13)	θ value	0.279714 (rank : 16)
Query Neighborhood Hits	18	Target Neighborhood Hits	19	Shared Neighborhood Hits	14
SwissProt Accessions	Q9GZZ9, Q96ST1	Gene names	UBE1DC1, UBA5
Domain Architecture	No domain graphic available
Description	Ubiquitin-activating enzyme E1 domain-containing protein 1 (UFM1- activating enzyme) (Ubiquitin-activating enzyme 5) (ThiFP1).

UE1D1_MOUSE
NC score	0.270224 (rank : 14)	θ value	0.21417 (rank : 15)
Query Neighborhood Hits	18	Target Neighborhood Hits	16	Shared Neighborhood Hits	12
SwissProt Accessions	Q8VE47, Q9CYD6	Gene names	Ube1dc1
Domain Architecture	No domain graphic available
Description	Ubiquitin-activating enzyme E1 domain-containing protein 1 (UFM1- activating enzyme).

ATG7_HUMAN
NC score	0.140630 (rank : 15)	θ value	0.0563607 (rank : 13)
Query Neighborhood Hits	18	Target Neighborhood Hits	14	Shared Neighborhood Hits	9
SwissProt Accessions	O95352, Q7L8L0, Q9BWP2, Q9UFH4	Gene names	ATG7, APG7L
Domain Architecture	No domain graphic available
Description	Autophagy-related protein 7 (APG7-like) (Ubiquitin-activating enzyme E1-like protein) (hAGP7).

ATG7_MOUSE
NC score	0.135933 (rank : 16)	θ value	0.21417 (rank : 14)
Query Neighborhood Hits	18	Target Neighborhood Hits	16	Shared Neighborhood Hits	9
SwissProt Accessions	Q9D906, Q3TCD9, Q8K4Q5	Gene names	Atg7, Apg7l
Domain Architecture	No domain graphic available
Description	Autophagy-related protein 7 (APG7-like) (Ubiquitin-activating enzyme E1-like protein) (mAGP7).

RAE1_MOUSE
NC score	0.022890 (rank : 17)	θ value	1.38821 (rank : 17)
Query Neighborhood Hits	18	Target Neighborhood Hits	32	Shared Neighborhood Hits	2
SwissProt Accessions	Q9QXG2, Q80UV8	Gene names	Chm, Rep1
Domain Architecture
Description	Rab proteins geranylgeranyltransferase component A 1 (Rab escort protein 1) (REP-1) (Choroideraemia protein homolog).

BBX_MOUSE
NC score	0.010580 (rank : 18)	θ value	6.88961 (rank : 18)
Query Neighborhood Hits	18	Target Neighborhood Hits	152	Shared Neighborhood Hits	2
SwissProt Accessions	Q8VBW5, Q3TZK1, Q6NXY8, Q6PEU3, Q8BQJ7, Q8C7E0, Q8CDQ0, Q8CDV1, Q8VI48, Q8VI49, Q8VI50, Q9CS94	Gene names	Bbx, Hbp2
Domain Architecture	No domain graphic available
Description	HMG box transcription factor BBX (Bobby sox homolog) (HMG box- containing protein 2).