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Network neighborhood for query Sequence : UBE1_HUMAN

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UBE1_HUMAN
SwissProt Accessions	P22314, Q96E13	Gene names	UBE1
Domain Architecture
Description	Ubiquitin-activating enzyme E1 (A1S9 protein).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

UBE1L_HUMAN
θ value	0 (rank : 1)	NC score	0.979326 (rank : 3)
Query Neighborhood Hits	19	Target Neighborhood Hits	26	Shared Neighborhood Hits	14
SwissProt Accessions	P41226	Gene names	UBE1L, UBE2
Domain Architecture
Description	Ubiquitin-activating enzyme E1 homolog (D8).

UBE1_HUMAN
θ value	0 (rank : 2)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	19	Target Neighborhood Hits	19	Shared Neighborhood Hits	19
SwissProt Accessions	P22314, Q96E13	Gene names	UBE1
Domain Architecture
Description	Ubiquitin-activating enzyme E1 (A1S9 protein).

UBE1_MOUSE
θ value	0 (rank : 3)	NC score	0.999046 (rank : 2)
Query Neighborhood Hits	19	Target Neighborhood Hits	21	Shared Neighborhood Hits	15
SwissProt Accessions	Q02053, Q542H8	Gene names	Ube1x, Uba1, Ube1
Domain Architecture
Description	Ubiquitin-activating enzyme E1 1.

ULE1B_MOUSE
θ value	2.86786e-30 (rank : 4)	NC score	0.722730 (rank : 7)
Query Neighborhood Hits	19	Target Neighborhood Hits	56	Shared Neighborhood Hits	14
SwissProt Accessions	Q9Z1F9, Q8BVX9	Gene names	Uble1b, Sae2, Uba2
Domain Architecture
Description	Ubiquitin-like 1-activating enzyme E1B (SUMO-1-activating enzyme subunit 2) (Anthracycline-associated resistance ARX).

ULE1B_HUMAN
θ value	2.42779e-29 (rank : 5)	NC score	0.720220 (rank : 9)
Query Neighborhood Hits	19	Target Neighborhood Hits	31	Shared Neighborhood Hits	14
SwissProt Accessions	Q9UBT2, O95605, Q9NTJ1, Q9UED2	Gene names	UBLE1B, SAE2, UBA2
Domain Architecture
Description	Ubiquitin-like 1-activating enzyme E1B (SUMO-1-activating enzyme subunit 2) (Anthracycline-associated resistance ARX).

ULE1A_HUMAN
θ value	2.27234e-27 (rank : 6)	NC score	0.742002 (rank : 4)
Query Neighborhood Hits	19	Target Neighborhood Hits	18	Shared Neighborhood Hits	14
SwissProt Accessions	Q9UBE0, O95717, Q9P020	Gene names	UBLE1A, AOS1, SAE1, SUA1
Domain Architecture
Description	Ubiquitin-like 1-activating enzyme E1A (SUMO-1-activating enzyme subunit 1).

UBA3_MOUSE
θ value	2.51237e-26 (rank : 7)	NC score	0.723078 (rank : 6)
Query Neighborhood Hits	19	Target Neighborhood Hits	22	Shared Neighborhood Hits	14
SwissProt Accessions	Q8C878, O88598, Q9D6B7	Gene names	Ube1c, Uba3
Domain Architecture	No domain graphic available
Description	NEDD8-activating enzyme E1 catalytic subunit (EC 6.3.2.-) (Ubiquitin- activating enzyme 3) (NEDD8-activating enzyme E1C) (Ubiquitin- activating enzyme E1C).

UBA3_HUMAN
θ value	3.28125e-26 (rank : 8)	NC score	0.722289 (rank : 8)
Query Neighborhood Hits	19	Target Neighborhood Hits	22	Shared Neighborhood Hits	14
SwissProt Accessions	Q8TBC4, O76088, Q9NTU3	Gene names	UBE1C, UBA3
Domain Architecture	No domain graphic available
Description	NEDD8-activating enzyme E1 catalytic subunit (EC 6.3.2.-) (Ubiquitin- activating enzyme 3) (NEDD8-activating enzyme E1C) (Ubiquitin- activating enzyme E1C).

ULE1A_MOUSE
θ value	9.54697e-26 (rank : 9)	NC score	0.737935 (rank : 5)
Query Neighborhood Hits	19	Target Neighborhood Hits	14	Shared Neighborhood Hits	14
SwissProt Accessions	Q9R1T2, Q3TWJ0, Q9CSW9	Gene names	Uble1a, Aos1, Sae1, Sua1, Ubl1a1
Domain Architecture
Description	Ubiquitin-like 1-activating enzyme E1A (SUMO-1-activating enzyme subunit 1).

ULA1_HUMAN
θ value	1.29331e-14 (rank : 10)	NC score	0.571579 (rank : 11)
Query Neighborhood Hits	19	Target Neighborhood Hits	18	Shared Neighborhood Hits	13
SwissProt Accessions	Q13564	Gene names	APPBP1
Domain Architecture	No domain graphic available
Description	NEDD8-activating enzyme E1 regulatory subunit (Amyloid protein-binding protein 1) (Amyloid beta precursor protein-binding protein 1, 59 kDa) (APP-BP1) (Protooncogene protein 1) (HPP1).

ULA1_MOUSE
θ value	7.09661e-13 (rank : 11)	NC score	0.560876 (rank : 12)
Query Neighborhood Hits	19	Target Neighborhood Hits	22	Shared Neighborhood Hits	13
SwissProt Accessions	Q8VBW6, Q8CFL6	Gene names	Appbp1
Domain Architecture	No domain graphic available
Description	NEDD8-activating enzyme E1 regulatory subunit (Amyloid protein-binding protein 1) (Amyloid beta precursor protein-binding protein 1, 59 kDa) (APP-BP1).

MOCS3_HUMAN
θ value	9.59137e-10 (rank : 12)	NC score	0.604913 (rank : 10)
Query Neighborhood Hits	19	Target Neighborhood Hits	20	Shared Neighborhood Hits	14
SwissProt Accessions	O95396	Gene names	MOCS3
Domain Architecture
Description	Molybdenum cofactor synthesis protein 3 (Molybdopterin synthase sulfurylase) (MPT synthase sulfurylase).

UE1D1_HUMAN
θ value	5.44631e-05 (rank : 13)	NC score	0.380825 (rank : 13)
Query Neighborhood Hits	19	Target Neighborhood Hits	19	Shared Neighborhood Hits	14
SwissProt Accessions	Q9GZZ9, Q96ST1	Gene names	UBE1DC1, UBA5
Domain Architecture	No domain graphic available
Description	Ubiquitin-activating enzyme E1 domain-containing protein 1 (UFM1- activating enzyme) (Ubiquitin-activating enzyme 5) (ThiFP1).

UE1D1_MOUSE
θ value	7.1131e-05 (rank : 14)	NC score	0.377395 (rank : 14)
Query Neighborhood Hits	19	Target Neighborhood Hits	16	Shared Neighborhood Hits	12
SwissProt Accessions	Q8VE47, Q9CYD6	Gene names	Ube1dc1
Domain Architecture	No domain graphic available
Description	Ubiquitin-activating enzyme E1 domain-containing protein 1 (UFM1- activating enzyme).

ZBT7A_HUMAN
θ value	0.47712 (rank : 15)	NC score	0.005053 (rank : 20)
Query Neighborhood Hits	19	Target Neighborhood Hits	823	Shared Neighborhood Hits	3
SwissProt Accessions	O95365, O00456	Gene names	ZBTB7A, FBI1, LRF, ZBTB7
Domain Architecture
Description	Zinc finger and BTB domain-containing protein 7A (Leukemia/lymphoma- related factor) (Factor that binds to inducer of short transcripts protein 1) (Factor binding IST protein 1) (FBI-1) (HIV-1 1st-binding protein 1) (TTF-I-interacting peptide 21) (TIP21).

GRB7_MOUSE
θ value	5.27518 (rank : 16)	NC score	0.007733 (rank : 19)
Query Neighborhood Hits	19	Target Neighborhood Hits	157	Shared Neighborhood Hits	2
SwissProt Accessions	Q03160	Gene names	Grb7
Domain Architecture
Description	Growth factor receptor-bound protein 7 (GRB7 adapter protein) (Epidermal growth factor receptor GRB-7).

FA35A_HUMAN
θ value	6.88961 (rank : 17)	NC score	0.013693 (rank : 17)
Query Neighborhood Hits	19	Target Neighborhood Hits	20	Shared Neighborhood Hits	2
SwissProt Accessions	Q86V20, O95885, Q9H991	Gene names	FAM35A
Domain Architecture	No domain graphic available
Description	Protein FAM35A.

PRI2_HUMAN
θ value	6.88961 (rank : 18)	NC score	0.013459 (rank : 18)
Query Neighborhood Hits	19	Target Neighborhood Hits	13	Shared Neighborhood Hits	2
SwissProt Accessions	P49643, Q53FJ8, Q6P1Q7, Q8WVL2, Q9H413	Gene names	PRIM2A, PRIM2
Domain Architecture
Description	DNA primase large subunit (EC 2.7.7.-) (DNA primase 58 kDa subunit) (p58).

REST_HUMAN
θ value	8.99809 (rank : 19)	NC score	-0.000832 (rank : 21)
Query Neighborhood Hits	19	Target Neighborhood Hits	1605	Shared Neighborhood Hits	2
SwissProt Accessions	P30622	Gene names	RSN, CYLN1
Domain Architecture
Description	Restin (Cytoplasmic linker protein 170 alpha-2) (CLIP-170) (Reed- Sternberg intermediate filament-associated protein) (Cytoplasmic linker protein 1).

ATG7_HUMAN
θ value	θ > 10 (rank : 20)	NC score	0.083319 (rank : 15)
Query Neighborhood Hits	19	Target Neighborhood Hits	14	Shared Neighborhood Hits	7
SwissProt Accessions	O95352, Q7L8L0, Q9BWP2, Q9UFH4	Gene names	ATG7, APG7L
Domain Architecture	No domain graphic available
Description	Autophagy-related protein 7 (APG7-like) (Ubiquitin-activating enzyme E1-like protein) (hAGP7).

ATG7_MOUSE
θ value	θ > 10 (rank : 21)	NC score	0.082796 (rank : 16)
Query Neighborhood Hits	19	Target Neighborhood Hits	16	Shared Neighborhood Hits	7
SwissProt Accessions	Q9D906, Q3TCD9, Q8K4Q5	Gene names	Atg7, Apg7l
Domain Architecture	No domain graphic available
Description	Autophagy-related protein 7 (APG7-like) (Ubiquitin-activating enzyme E1-like protein) (mAGP7).

Hits sorted by NC score

UBE1_HUMAN
NC score	0.999962 (rank : 1)	θ value	0 (rank : 2)
Query Neighborhood Hits	19	Target Neighborhood Hits	19	Shared Neighborhood Hits	19
SwissProt Accessions	P22314, Q96E13	Gene names	UBE1
Domain Architecture
Description	Ubiquitin-activating enzyme E1 (A1S9 protein).

UBE1_MOUSE
NC score	0.999046 (rank : 2)	θ value	0 (rank : 3)
Query Neighborhood Hits	19	Target Neighborhood Hits	21	Shared Neighborhood Hits	15
SwissProt Accessions	Q02053, Q542H8	Gene names	Ube1x, Uba1, Ube1
Domain Architecture
Description	Ubiquitin-activating enzyme E1 1.

UBE1L_HUMAN
NC score	0.979326 (rank : 3)	θ value	0 (rank : 1)
Query Neighborhood Hits	19	Target Neighborhood Hits	26	Shared Neighborhood Hits	14
SwissProt Accessions	P41226	Gene names	UBE1L, UBE2
Domain Architecture
Description	Ubiquitin-activating enzyme E1 homolog (D8).

ULE1A_HUMAN
NC score	0.742002 (rank : 4)	θ value	2.27234e-27 (rank : 6)
Query Neighborhood Hits	19	Target Neighborhood Hits	18	Shared Neighborhood Hits	14
SwissProt Accessions	Q9UBE0, O95717, Q9P020	Gene names	UBLE1A, AOS1, SAE1, SUA1
Domain Architecture
Description	Ubiquitin-like 1-activating enzyme E1A (SUMO-1-activating enzyme subunit 1).

ULE1A_MOUSE
NC score	0.737935 (rank : 5)	θ value	9.54697e-26 (rank : 9)
Query Neighborhood Hits	19	Target Neighborhood Hits	14	Shared Neighborhood Hits	14
SwissProt Accessions	Q9R1T2, Q3TWJ0, Q9CSW9	Gene names	Uble1a, Aos1, Sae1, Sua1, Ubl1a1
Domain Architecture
Description	Ubiquitin-like 1-activating enzyme E1A (SUMO-1-activating enzyme subunit 1).

UBA3_MOUSE
NC score	0.723078 (rank : 6)	θ value	2.51237e-26 (rank : 7)
Query Neighborhood Hits	19	Target Neighborhood Hits	22	Shared Neighborhood Hits	14
SwissProt Accessions	Q8C878, O88598, Q9D6B7	Gene names	Ube1c, Uba3
Domain Architecture	No domain graphic available
Description	NEDD8-activating enzyme E1 catalytic subunit (EC 6.3.2.-) (Ubiquitin- activating enzyme 3) (NEDD8-activating enzyme E1C) (Ubiquitin- activating enzyme E1C).

ULE1B_MOUSE
NC score	0.722730 (rank : 7)	θ value	2.86786e-30 (rank : 4)
Query Neighborhood Hits	19	Target Neighborhood Hits	56	Shared Neighborhood Hits	14
SwissProt Accessions	Q9Z1F9, Q8BVX9	Gene names	Uble1b, Sae2, Uba2
Domain Architecture
Description	Ubiquitin-like 1-activating enzyme E1B (SUMO-1-activating enzyme subunit 2) (Anthracycline-associated resistance ARX).

UBA3_HUMAN
NC score	0.722289 (rank : 8)	θ value	3.28125e-26 (rank : 8)
Query Neighborhood Hits	19	Target Neighborhood Hits	22	Shared Neighborhood Hits	14
SwissProt Accessions	Q8TBC4, O76088, Q9NTU3	Gene names	UBE1C, UBA3
Domain Architecture	No domain graphic available
Description	NEDD8-activating enzyme E1 catalytic subunit (EC 6.3.2.-) (Ubiquitin- activating enzyme 3) (NEDD8-activating enzyme E1C) (Ubiquitin- activating enzyme E1C).

ULE1B_HUMAN
NC score	0.720220 (rank : 9)	θ value	2.42779e-29 (rank : 5)
Query Neighborhood Hits	19	Target Neighborhood Hits	31	Shared Neighborhood Hits	14
SwissProt Accessions	Q9UBT2, O95605, Q9NTJ1, Q9UED2	Gene names	UBLE1B, SAE2, UBA2
Domain Architecture
Description	Ubiquitin-like 1-activating enzyme E1B (SUMO-1-activating enzyme subunit 2) (Anthracycline-associated resistance ARX).

MOCS3_HUMAN
NC score	0.604913 (rank : 10)	θ value	9.59137e-10 (rank : 12)
Query Neighborhood Hits	19	Target Neighborhood Hits	20	Shared Neighborhood Hits	14
SwissProt Accessions	O95396	Gene names	MOCS3
Domain Architecture
Description	Molybdenum cofactor synthesis protein 3 (Molybdopterin synthase sulfurylase) (MPT synthase sulfurylase).

ULA1_HUMAN
NC score	0.571579 (rank : 11)	θ value	1.29331e-14 (rank : 10)
Query Neighborhood Hits	19	Target Neighborhood Hits	18	Shared Neighborhood Hits	13
SwissProt Accessions	Q13564	Gene names	APPBP1
Domain Architecture	No domain graphic available
Description	NEDD8-activating enzyme E1 regulatory subunit (Amyloid protein-binding protein 1) (Amyloid beta precursor protein-binding protein 1, 59 kDa) (APP-BP1) (Protooncogene protein 1) (HPP1).

ULA1_MOUSE
NC score	0.560876 (rank : 12)	θ value	7.09661e-13 (rank : 11)
Query Neighborhood Hits	19	Target Neighborhood Hits	22	Shared Neighborhood Hits	13
SwissProt Accessions	Q8VBW6, Q8CFL6	Gene names	Appbp1
Domain Architecture	No domain graphic available
Description	NEDD8-activating enzyme E1 regulatory subunit (Amyloid protein-binding protein 1) (Amyloid beta precursor protein-binding protein 1, 59 kDa) (APP-BP1).

UE1D1_HUMAN
NC score	0.380825 (rank : 13)	θ value	5.44631e-05 (rank : 13)
Query Neighborhood Hits	19	Target Neighborhood Hits	19	Shared Neighborhood Hits	14
SwissProt Accessions	Q9GZZ9, Q96ST1	Gene names	UBE1DC1, UBA5
Domain Architecture	No domain graphic available
Description	Ubiquitin-activating enzyme E1 domain-containing protein 1 (UFM1- activating enzyme) (Ubiquitin-activating enzyme 5) (ThiFP1).

UE1D1_MOUSE
NC score	0.377395 (rank : 14)	θ value	7.1131e-05 (rank : 14)
Query Neighborhood Hits	19	Target Neighborhood Hits	16	Shared Neighborhood Hits	12
SwissProt Accessions	Q8VE47, Q9CYD6	Gene names	Ube1dc1
Domain Architecture	No domain graphic available
Description	Ubiquitin-activating enzyme E1 domain-containing protein 1 (UFM1- activating enzyme).

ATG7_HUMAN
NC score	0.083319 (rank : 15)	θ value	θ > 10 (rank : 20)
Query Neighborhood Hits	19	Target Neighborhood Hits	14	Shared Neighborhood Hits	7
SwissProt Accessions	O95352, Q7L8L0, Q9BWP2, Q9UFH4	Gene names	ATG7, APG7L
Domain Architecture	No domain graphic available
Description	Autophagy-related protein 7 (APG7-like) (Ubiquitin-activating enzyme E1-like protein) (hAGP7).

ATG7_MOUSE
NC score	0.082796 (rank : 16)	θ value	θ > 10 (rank : 21)
Query Neighborhood Hits	19	Target Neighborhood Hits	16	Shared Neighborhood Hits	7
SwissProt Accessions	Q9D906, Q3TCD9, Q8K4Q5	Gene names	Atg7, Apg7l
Domain Architecture	No domain graphic available
Description	Autophagy-related protein 7 (APG7-like) (Ubiquitin-activating enzyme E1-like protein) (mAGP7).

FA35A_HUMAN
NC score	0.013693 (rank : 17)	θ value	6.88961 (rank : 17)
Query Neighborhood Hits	19	Target Neighborhood Hits	20	Shared Neighborhood Hits	2
SwissProt Accessions	Q86V20, O95885, Q9H991	Gene names	FAM35A
Domain Architecture	No domain graphic available
Description	Protein FAM35A.

PRI2_HUMAN
NC score	0.013459 (rank : 18)	θ value	6.88961 (rank : 18)
Query Neighborhood Hits	19	Target Neighborhood Hits	13	Shared Neighborhood Hits	2
SwissProt Accessions	P49643, Q53FJ8, Q6P1Q7, Q8WVL2, Q9H413	Gene names	PRIM2A, PRIM2
Domain Architecture
Description	DNA primase large subunit (EC 2.7.7.-) (DNA primase 58 kDa subunit) (p58).

GRB7_MOUSE
NC score	0.007733 (rank : 19)	θ value	5.27518 (rank : 16)
Query Neighborhood Hits	19	Target Neighborhood Hits	157	Shared Neighborhood Hits	2
SwissProt Accessions	Q03160	Gene names	Grb7
Domain Architecture
Description	Growth factor receptor-bound protein 7 (GRB7 adapter protein) (Epidermal growth factor receptor GRB-7).

ZBT7A_HUMAN
NC score	0.005053 (rank : 20)	θ value	0.47712 (rank : 15)
Query Neighborhood Hits	19	Target Neighborhood Hits	823	Shared Neighborhood Hits	3
SwissProt Accessions	O95365, O00456	Gene names	ZBTB7A, FBI1, LRF, ZBTB7
Domain Architecture
Description	Zinc finger and BTB domain-containing protein 7A (Leukemia/lymphoma- related factor) (Factor that binds to inducer of short transcripts protein 1) (Factor binding IST protein 1) (FBI-1) (HIV-1 1st-binding protein 1) (TTF-I-interacting peptide 21) (TIP21).

REST_HUMAN
NC score	-0.000832 (rank : 21)	θ value	8.99809 (rank : 19)
Query Neighborhood Hits	19	Target Neighborhood Hits	1605	Shared Neighborhood Hits	2
SwissProt Accessions	P30622	Gene names	RSN, CYLN1
Domain Architecture
Description	Restin (Cytoplasmic linker protein 170 alpha-2) (CLIP-170) (Reed- Sternberg intermediate filament-associated protein) (Cytoplasmic linker protein 1).