Please be patient as the page loads

Stop Image Loading/Displaying

Network neighborhood for query Sequence : UBP21_MOUSE

For an explanation of this page, click here

UBP21_MOUSE
SwissProt Accessions	Q9QZL6, Q9D0R1	Gene names	Usp21, Usp23
Domain Architecture
Description	Ubiquitin carboxyl-terminal hydrolase 21 (EC 3.1.2.15) (Ubiquitin thioesterase 21) (Ubiquitin-specific-processing protease 21) (Deubiquitinating enzyme 21).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

UBP21_HUMAN
θ value	0 (rank : 1)	NC score	0.997941 (rank : 2)
Query Neighborhood Hits	101	Target Neighborhood Hits	95	Shared Neighborhood Hits	86
SwissProt Accessions	Q9UK80, Q9BTV1, Q9NYN4	Gene names	USP21, USP23
Domain Architecture
Description	Ubiquitin carboxyl-terminal hydrolase 21 (EC 3.1.2.15) (Ubiquitin thioesterase 21) (Ubiquitin-specific-processing protease 21) (Deubiquitinating enzyme 21) (NEDD8-specific protease).

UBP21_MOUSE
θ value	0 (rank : 2)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	101	Target Neighborhood Hits	101	Shared Neighborhood Hits	101
SwissProt Accessions	Q9QZL6, Q9D0R1	Gene names	Usp21, Usp23
Domain Architecture
Description	Ubiquitin carboxyl-terminal hydrolase 21 (EC 3.1.2.15) (Ubiquitin thioesterase 21) (Ubiquitin-specific-processing protease 21) (Deubiquitinating enzyme 21).

UBP2_HUMAN
θ value	4.49445e-92 (rank : 3)	NC score	0.975969 (rank : 3)
Query Neighborhood Hits	101	Target Neighborhood Hits	84	Shared Neighborhood Hits	74
SwissProt Accessions	O75604, Q96MB9, Q9BQ21	Gene names	USP2, UBP41
Domain Architecture
Description	Ubiquitin carboxyl-terminal hydrolase 2 (EC 3.1.2.15) (Ubiquitin thioesterase 2) (Ubiquitin-specific-processing protease 2) (Deubiquitinating enzyme 2) (41 kDa ubiquitin-specific protease).

UBP2_MOUSE
θ value	2.91321e-91 (rank : 4)	NC score	0.975454 (rank : 4)
Query Neighborhood Hits	101	Target Neighborhood Hits	86	Shared Neighborhood Hits	74
SwissProt Accessions	O88623, Q6X4T9, Q6X4U1, Q8VD74, Q9JJ87	Gene names	Usp2, Ubp41
Domain Architecture
Description	Ubiquitin carboxyl-terminal hydrolase 2 (EC 3.1.2.15) (Ubiquitin thioesterase 2) (Ubiquitin-specific-processing protease 2) (Deubiquitinating enzyme 2) (41 kDa ubiquitin-specific protease).

UBP8_HUMAN
θ value	1.66964e-54 (rank : 5)	NC score	0.883610 (rank : 14)
Query Neighborhood Hits	101	Target Neighborhood Hits	751	Shared Neighborhood Hits	75
SwissProt Accessions	P40818, Q7Z3U2, Q86VA0, Q8IWI7	Gene names	USP8, KIAA0055, UBPY
Domain Architecture
Description	Ubiquitin carboxyl-terminal hydrolase 8 (EC 3.1.2.15) (Ubiquitin thioesterase 8) (Ubiquitin-specific-processing protease 8) (Deubiquitinating enzyme 8) (hUBPy).

UBP8_MOUSE
θ value	4.85792e-54 (rank : 6)	NC score	0.927078 (rank : 8)
Query Neighborhood Hits	101	Target Neighborhood Hits	362	Shared Neighborhood Hits	75
SwissProt Accessions	Q80U87, Q80YP2, Q8R0D3, Q9EQU1, Q9WVP5	Gene names	Usp8, Kiaa0055, Ubpy
Domain Architecture
Description	Ubiquitin carboxyl-terminal hydrolase 8 (EC 3.1.2.15) (Ubiquitin thioesterase 8) (Ubiquitin-specific-processing protease 8) (Deubiquitinating enzyme 8) (mUBPy).

UBP50_MOUSE
θ value	1.73182e-43 (rank : 7)	NC score	0.949177 (rank : 5)
Query Neighborhood Hits	101	Target Neighborhood Hits	80	Shared Neighborhood Hits	73
SwissProt Accessions	Q6P8X6, Q9D558, Q9D9E7	Gene names	Usp50
Domain Architecture	No domain graphic available
Description	Putative ubiquitin carboxyl-terminal hydrolase 50 (EC 3.1.2.15) (Ubiquitin thioesterase 50) (Ubiquitin-specific-processing protease 50) (Deubiquitinating enzyme 50).

UBP3_MOUSE
θ value	5.57106e-42 (rank : 8)	NC score	0.931881 (rank : 7)
Query Neighborhood Hits	101	Target Neighborhood Hits	89	Shared Neighborhood Hits	73
SwissProt Accessions	Q91W36	Gene names	Usp3
Domain Architecture
Description	Ubiquitin carboxyl-terminal hydrolase 3 (EC 3.1.2.15) (Ubiquitin thioesterase 3) (Ubiquitin-specific-processing protease 3) (Deubiquitinating enzyme 3).

UBP3_HUMAN
θ value	7.04741e-37 (rank : 9)	NC score	0.924564 (rank : 9)
Query Neighborhood Hits	101	Target Neighborhood Hits	88	Shared Neighborhood Hits	73
SwissProt Accessions	Q9Y6I4	Gene names	USP3
Domain Architecture
Description	Ubiquitin carboxyl-terminal hydrolase 3 (EC 3.1.2.15) (Ubiquitin thioesterase 3) (Ubiquitin-specific-processing protease 3) (Deubiquitinating enzyme 3).

UBP50_HUMAN
θ value	2.77131e-33 (rank : 10)	NC score	0.935920 (rank : 6)
Query Neighborhood Hits	101	Target Neighborhood Hits	75	Shared Neighborhood Hits	68
SwissProt Accessions	Q70EL3	Gene names	USP50
Domain Architecture	No domain graphic available
Description	Inactive ubiquitin carboxyl-terminal hydrolase 50 (Inactive ubiquitin- specific peptidase 50).

UBPW_MOUSE
θ value	1.28732e-30 (rank : 11)	NC score	0.904230 (rank : 12)
Query Neighborhood Hits	101	Target Neighborhood Hits	89	Shared Neighborhood Hits	73
SwissProt Accessions	Q61068	Gene names	Dub1, Dub-1
Domain Architecture
Description	Ubiquitin carboxyl-terminal hydrolase DUB-1 (EC 3.1.2.15) (Ubiquitin thioesterase DUB-1) (Ubiquitin-specific-processing protease DUB-1) (Deubiquitinating enzyme 1).

UBP22_MOUSE
θ value	2.19584e-30 (rank : 12)	NC score	0.906563 (rank : 10)
Query Neighborhood Hits	101	Target Neighborhood Hits	87	Shared Neighborhood Hits	73
SwissProt Accessions	Q5DU02, Q5SU81, Q66JV8	Gene names	Usp22, Kiaa1063
Domain Architecture	No domain graphic available
Description	Ubiquitin carboxyl-terminal hydrolase 22 (EC 3.1.2.15) (Ubiquitin thioesterase 22) (Ubiquitin-specific-processing protease 22) (Deubiquitinating enzyme 22).

UBP36_HUMAN
θ value	2.19584e-30 (rank : 13)	NC score	0.872762 (rank : 20)
Query Neighborhood Hits	101	Target Neighborhood Hits	232	Shared Neighborhood Hits	82
SwissProt Accessions	Q9P275, Q8NDM8, Q9NVC8	Gene names	USP36, KIAA1453
Domain Architecture
Description	Ubiquitin carboxyl-terminal hydrolase 36 (EC 3.1.2.15) (Ubiquitin thioesterase 36) (Ubiquitin-specific-processing protease 36) (Deubiquitinating enzyme 36).

UBP22_HUMAN
θ value	6.38894e-30 (rank : 14)	NC score	0.905688 (rank : 11)
Query Neighborhood Hits	101	Target Neighborhood Hits	87	Shared Neighborhood Hits	73
SwissProt Accessions	Q9UPT9	Gene names	USP22, KIAA1063, USP3L
Domain Architecture	No domain graphic available
Description	Ubiquitin carboxyl-terminal hydrolase 22 (EC 3.1.2.15) (Ubiquitin thioesterase 22) (Ubiquitin-specific-processing protease 22) (Deubiquitinating enzyme 22).

UBP15_HUMAN
θ value	1.85889e-29 (rank : 15)	NC score	0.854493 (rank : 25)
Query Neighborhood Hits	101	Target Neighborhood Hits	92	Shared Neighborhood Hits	73
SwissProt Accessions	Q9Y4E8, Q9HCA6, Q9UNP0, Q9Y5B5	Gene names	USP15, KIAA0529
Domain Architecture
Description	Ubiquitin carboxyl-terminal hydrolase 15 (EC 3.1.2.15) (Ubiquitin thioesterase 15) (Ubiquitin-specific-processing protease 15) (Deubiquitinating enzyme 15) (Unph-2) (Unph4).

UBP15_MOUSE
θ value	1.85889e-29 (rank : 16)	NC score	0.854961 (rank : 24)
Query Neighborhood Hits	101	Target Neighborhood Hits	88	Shared Neighborhood Hits	73
SwissProt Accessions	Q8R5H1, Q3UL25	Gene names	Usp15
Domain Architecture
Description	Ubiquitin carboxyl-terminal hydrolase 15 (EC 3.1.2.15) (Ubiquitin thioesterase 15) (Ubiquitin-specific-processing protease 15) (Deubiquitinating enzyme 15).

UBP4_HUMAN
θ value	3.17079e-29 (rank : 17)	NC score	0.852706 (rank : 26)
Query Neighborhood Hits	101	Target Neighborhood Hits	89	Shared Neighborhood Hits	73
SwissProt Accessions	Q13107, O43452, O43453	Gene names	USP4, UNP, UNPH
Domain Architecture
Description	Ubiquitin carboxyl-terminal hydrolase 4 (EC 3.1.2.15) (Ubiquitin thioesterase 4) (Ubiquitin-specific-processing protease 4) (Deubiquitinating enzyme 4) (Ubiquitous nuclear protein homolog).

UBP42_HUMAN
θ value	1.57365e-28 (rank : 18)	NC score	0.847185 (rank : 29)
Query Neighborhood Hits	101	Target Neighborhood Hits	445	Shared Neighborhood Hits	76
SwissProt Accessions	Q9H9J4, Q3C166, Q6P9B4	Gene names	USP42
Domain Architecture	No domain graphic available
Description	Ubiquitin carboxyl-terminal hydrolase 42 (EC 3.1.2.15) (Ubiquitin thioesterase 42) (Ubiquitin-specific-processing protease 42) (Deubiquitinating enzyme 42).

UBP4_MOUSE
θ value	7.80994e-28 (rank : 19)	NC score	0.851403 (rank : 27)
Query Neighborhood Hits	101	Target Neighborhood Hits	90	Shared Neighborhood Hits	74
SwissProt Accessions	P35123, O54704	Gene names	Usp4, Unp
Domain Architecture
Description	Ubiquitin carboxyl-terminal hydrolase 4 (EC 3.1.2.15) (Ubiquitin thioesterase 4) (Ubiquitin-specific-processing protease 4) (Deubiquitinating enzyme 4) (Ubiquitous nuclear protein).

UBP32_HUMAN
θ value	1.33217e-27 (rank : 20)	NC score	0.769597 (rank : 39)
Query Neighborhood Hits	101	Target Neighborhood Hits	170	Shared Neighborhood Hits	74
SwissProt Accessions	Q8NFA0, Q9BX85, Q9Y591	Gene names	USP32, USP10
Domain Architecture
Description	Ubiquitin carboxyl-terminal hydrolase 32 (EC 3.1.2.15) (Ubiquitin thioesterase 32) (Ubiquitin-specific-processing protease 32) (Deubiquitinating enzyme 32) (NY-REN-60 antigen).

UBP6_HUMAN
θ value	1.73987e-27 (rank : 21)	NC score	0.727644 (rank : 42)
Query Neighborhood Hits	101	Target Neighborhood Hits	188	Shared Neighborhood Hits	75
SwissProt Accessions	P35125, Q15634, Q86WP6, Q8IWT4	Gene names	USP6, TRE2
Domain Architecture
Description	Ubiquitin carboxyl-terminal hydrolase 6 (EC 3.1.2.15) (Ubiquitin thioesterase 6) (Ubiquitin-specific-processing protease 6) (Deubiquitinating enzyme 6) (Proto-oncogene TRE-2).

UBP51_HUMAN
θ value	6.61148e-27 (rank : 22)	NC score	0.898390 (rank : 13)
Query Neighborhood Hits	101	Target Neighborhood Hits	162	Shared Neighborhood Hits	76
SwissProt Accessions	Q70EK9, Q8IWJ8	Gene names	USP51
Domain Architecture	No domain graphic available
Description	Ubiquitin carboxyl-terminal hydrolase 51 (EC 3.1.2.15) (Ubiquitin thioesterase 51) (Ubiquitin-specific-processing protease 51) (Deubiquitinating enzyme 51).

UBP33_HUMAN
θ value	1.47289e-26 (rank : 23)	NC score	0.873544 (rank : 19)
Query Neighborhood Hits	101	Target Neighborhood Hits	157	Shared Neighborhood Hits	73
SwissProt Accessions	Q8TEY7, Q8TEY6, Q96AV6, Q9H9F0, Q9UPQ5	Gene names	USP33, KIAA1097, VDU1
Domain Architecture
Description	Ubiquitin carboxyl-terminal hydrolase 33 (EC 3.1.2.15) (Ubiquitin thioesterase 33) (Ubiquitin-specific-processing protease 33) (Deubiquitinating enzyme 33) (VHL-interacting deubiquitinating enzyme 1).

UBP11_HUMAN
θ value	1.24688e-25 (rank : 24)	NC score	0.860314 (rank : 22)
Query Neighborhood Hits	101	Target Neighborhood Hits	88	Shared Neighborhood Hits	73
SwissProt Accessions	P51784, Q8IUG6, Q9BWE1	Gene names	USP11, UHX1
Domain Architecture
Description	Ubiquitin carboxyl-terminal hydrolase 11 (EC 3.1.2.15) (Ubiquitin thioesterase 11) (Ubiquitin-specific-processing protease 11) (Deubiquitinating enzyme 11).

UBP49_MOUSE
θ value	4.73814e-25 (rank : 25)	NC score	0.850034 (rank : 28)
Query Neighborhood Hits	101	Target Neighborhood Hits	91	Shared Neighborhood Hits	74
SwissProt Accessions	Q6P9L4	Gene names	Usp49
Domain Architecture	No domain graphic available
Description	Ubiquitin carboxyl-terminal hydrolase 49 (EC 3.1.2.15) (Ubiquitin thioesterase 49) (Ubiquitin-specific-processing protease 49) (Deubiquitinating enzyme 49).

UBP12_HUMAN
θ value	2.35151e-24 (rank : 26)	NC score	0.881374 (rank : 15)
Query Neighborhood Hits	101	Target Neighborhood Hits	85	Shared Neighborhood Hits	73
SwissProt Accessions	O75317	Gene names	USP12, UBH1, USP12L1
Domain Architecture
Description	Ubiquitin carboxyl-terminal hydrolase 12 (EC 3.1.2.15) (Ubiquitin thioesterase 12) (Ubiquitin-specific-processing protease 12) (Deubiquitinating enzyme 12) (Ubiquitin-hydrolyzing enzyme 1).

UBP20_HUMAN
θ value	6.84181e-24 (rank : 27)	NC score	0.875259 (rank : 18)
Query Neighborhood Hits	101	Target Neighborhood Hits	113	Shared Neighborhood Hits	75
SwissProt Accessions	Q9Y2K6, Q96LG5, Q9UQN8, Q9UQP0	Gene names	USP20, KIAA1003, LSFR3A
Domain Architecture
Description	Ubiquitin carboxyl-terminal hydrolase 20 (EC 3.1.2.15) (Ubiquitin thioesterase 20) (Ubiquitin-specific-processing protease 20) (Deubiquitinating enzyme 20).

UBP46_HUMAN
θ value	1.16704e-23 (rank : 28)	NC score	0.875354 (rank : 16)
Query Neighborhood Hits	101	Target Neighborhood Hits	81	Shared Neighborhood Hits	73
SwissProt Accessions	P62068, Q80V95, Q9H7U4, Q9H9T8	Gene names	USP46
Domain Architecture
Description	Ubiquitin carboxyl-terminal hydrolase 46 (EC 3.1.2.15) (Ubiquitin thioesterase 46) (Ubiquitin-specific-processing protease 46) (Deubiquitinating enzyme 46).

UBP46_MOUSE
θ value	1.16704e-23 (rank : 29)	NC score	0.875354 (rank : 17)
Query Neighborhood Hits	101	Target Neighborhood Hits	81	Shared Neighborhood Hits	73
SwissProt Accessions	P62069, Q80V95, Q9H7U4, Q9H9T8	Gene names	Usp46
Domain Architecture
Description	Ubiquitin carboxyl-terminal hydrolase 46 (EC 3.1.2.15) (Ubiquitin thioesterase 46) (Ubiquitin-specific-processing protease 46) (Deubiquitinating enzyme 46).

UBP44_HUMAN
θ value	3.39556e-23 (rank : 30)	NC score	0.859918 (rank : 23)
Query Neighborhood Hits	101	Target Neighborhood Hits	91	Shared Neighborhood Hits	73
SwissProt Accessions	Q9H0E7	Gene names	USP44
Domain Architecture
Description	Ubiquitin carboxyl-terminal hydrolase 44 (EC 3.1.2.15) (Ubiquitin thioesterase 44) (Ubiquitin-specific-processing protease 44) (Deubiquitinating enzyme 44).

UB17L_HUMAN
θ value	9.87957e-23 (rank : 31)	NC score	0.870303 (rank : 21)
Query Neighborhood Hits	101	Target Neighborhood Hits	83	Shared Neighborhood Hits	73
SwissProt Accessions	Q7RTZ2	Gene names	USP17L
Domain Architecture	No domain graphic available
Description	Ubiquitin carboxyl-terminal hydrolase 17-like protein (EC 3.1.2.15) (Ubiquitin thioesterase 17-like) (Ubiquitin-specific-processing protease 17-like) (Deubiquitinating enzyme 17-like).

UBP43_HUMAN
θ value	6.40375e-22 (rank : 32)	NC score	0.829459 (rank : 33)
Query Neighborhood Hits	101	Target Neighborhood Hits	144	Shared Neighborhood Hits	75
SwissProt Accessions	Q70EL4, Q8N2C5, Q96DQ6	Gene names	USP43
Domain Architecture	No domain graphic available
Description	Ubiquitin carboxyl-terminal hydrolase 43 (EC 3.1.2.15) (Ubiquitin thioesterase 43) (Ubiquitin-specific-processing protease 43) (Deubiquitinating enzyme 43).

UBP49_HUMAN
θ value	1.86321e-21 (rank : 33)	NC score	0.844907 (rank : 30)
Query Neighborhood Hits	101	Target Neighborhood Hits	100	Shared Neighborhood Hits	73
SwissProt Accessions	Q70CQ1, Q96CK4	Gene names	USP49
Domain Architecture	No domain graphic available
Description	Ubiquitin carboxyl-terminal hydrolase 49 (EC 3.1.2.15) (Ubiquitin thioesterase 49) (Ubiquitin-specific-processing protease 49) (Deubiquitinating enzyme 49).

UBP43_MOUSE
θ value	4.58923e-20 (rank : 34)	NC score	0.830715 (rank : 32)
Query Neighborhood Hits	101	Target Neighborhood Hits	130	Shared Neighborhood Hits	74
SwissProt Accessions	Q8BUM9, Q8VDP5	Gene names	Usp43
Domain Architecture	No domain graphic available
Description	Ubiquitin carboxyl-terminal hydrolase 43 (EC 3.1.2.15) (Ubiquitin thioesterase 43) (Ubiquitin-specific-processing protease 43) (Deubiquitinating enzyme 43).

UBP31_HUMAN
θ value	1.74391e-19 (rank : 35)	NC score	0.815158 (rank : 34)
Query Neighborhood Hits	101	Target Neighborhood Hits	293	Shared Neighborhood Hits	77
SwissProt Accessions	Q70CQ4, Q6AW97, Q6ZTC0, Q6ZTN2, Q9ULL7	Gene names	USP31, KIAA1203
Domain Architecture	No domain graphic available
Description	Ubiquitin carboxyl-terminal hydrolase 31 (EC 3.1.2.15) (Ubiquitin thioesterase 31) (Ubiquitin-specific-processing protease 31) (Deubiquitinating enzyme 31).

UBP48_HUMAN
θ value	6.20254e-17 (rank : 36)	NC score	0.783654 (rank : 37)
Query Neighborhood Hits	101	Target Neighborhood Hits	101	Shared Neighborhood Hits	73
SwissProt Accessions	Q86UV5, Q2M3I4, Q5SZI4, Q5T3T5, Q6NX53, Q8N3F6, Q96F64, Q96IQ3, Q9H5N3, Q9H5T7, Q9NUJ6, Q9NXR0	Gene names	USP48
Domain Architecture	No domain graphic available
Description	Ubiquitin carboxyl-terminal hydrolase 48 (EC 3.1.2.15) (Ubiquitin thioesterase 48) (Ubiquitin-specific-processing protease 48) (Deubiquitinating enzyme 48).

UBP48_MOUSE
θ value	1.058e-16 (rank : 37)	NC score	0.780714 (rank : 38)
Query Neighborhood Hits	101	Target Neighborhood Hits	124	Shared Neighborhood Hits	73
SwissProt Accessions	Q3V0C5, Q3TM39, Q571J9, Q8VDJ1	Gene names	Usp48, Kiaa4202
Domain Architecture	No domain graphic available
Description	Ubiquitin carboxyl-terminal hydrolase 48 (EC 3.1.2.15) (Ubiquitin thioesterase 48) (Ubiquitin-specific-processing protease 48) (Deubiquitinating enzyme 48).

UBP47_MOUSE
θ value	7.58209e-15 (rank : 38)	NC score	0.712680 (rank : 46)
Query Neighborhood Hits	101	Target Neighborhood Hits	135	Shared Neighborhood Hits	71
SwissProt Accessions	Q8BY87, Q5EBP2, Q6KAR9, Q80V06, Q8BHU1, Q8BI15, Q8BI16, Q8BUW4, Q91X25	Gene names	Usp47
Domain Architecture	No domain graphic available
Description	Ubiquitin carboxyl-terminal hydrolase 47 (EC 3.1.2.15) (Ubiquitin thioesterase 47) (Ubiquitin-specific-processing protease 47) (Deubiquitinating enzyme 47).

UBP24_HUMAN
θ value	8.38298e-14 (rank : 39)	NC score	0.718741 (rank : 44)
Query Neighborhood Hits	101	Target Neighborhood Hits	96	Shared Neighborhood Hits	71
SwissProt Accessions	Q9UPU5, Q6ZSY2, Q8N2Y4, Q9NXD1	Gene names	USP24, KIAA1057
Domain Architecture	No domain graphic available
Description	Ubiquitin carboxyl-terminal hydrolase 24 (EC 3.1.2.15) (Ubiquitin thioesterase 24) (Ubiquitin-specific-processing protease 24) (Deubiquitinating enzyme 24).

UBP37_HUMAN
θ value	4.16044e-13 (rank : 40)	NC score	0.698041 (rank : 52)
Query Neighborhood Hits	101	Target Neighborhood Hits	208	Shared Neighborhood Hits	73
SwissProt Accessions	Q86T82, Q9HCH8	Gene names	USP37, KIAA1594
Domain Architecture
Description	Ubiquitin carboxyl-terminal hydrolase 37 (EC 3.1.2.15) (Ubiquitin thioesterase 37) (Ubiquitin-specific-processing protease 37) (Deubiquitinating enzyme 37).

UBP18_MOUSE
θ value	5.43371e-13 (rank : 41)	NC score	0.791888 (rank : 36)
Query Neighborhood Hits	101	Target Neighborhood Hits	77	Shared Neighborhood Hits	70
SwissProt Accessions	Q9WTV6	Gene names	Usp18, Ubp43
Domain Architecture
Description	Ubl carboxyl-terminal hydrolase 18 (EC 3.1.2.-) (Ubl thioesterase 18) (ISG15-specific-processing protease) (43 kDa ISG15-specific protease).

UBP16_HUMAN
θ value	2.69671e-12 (rank : 42)	NC score	0.836403 (rank : 31)
Query Neighborhood Hits	101	Target Neighborhood Hits	126	Shared Neighborhood Hits	73
SwissProt Accessions	Q9Y5T5, Q8NEL3	Gene names	USP16
Domain Architecture
Description	Ubiquitin carboxyl-terminal hydrolase 16 (EC 3.1.2.15) (Ubiquitin thioesterase 16) (Ubiquitin-specific-processing protease 16) (Deubiquitinating enzyme 16) (Ubiquitin-processing protease UBP-M).

UBP47_HUMAN
θ value	3.52202e-12 (rank : 43)	NC score	0.702761 (rank : 49)
Query Neighborhood Hits	101	Target Neighborhood Hits	149	Shared Neighborhood Hits	71
SwissProt Accessions	Q96K76, Q658U0, Q86Y73, Q8TEP6, Q9BWI0, Q9NWN1	Gene names	USP47
Domain Architecture	No domain graphic available
Description	Ubiquitin carboxyl-terminal hydrolase 47 (EC 3.1.2.15) (Ubiquitin thioesterase 47) (Ubiquitin-specific-processing protease 47) (Deubiquitinating enzyme 47).

UBP10_MOUSE
θ value	7.84624e-12 (rank : 44)	NC score	0.726307 (rank : 43)
Query Neighborhood Hits	101	Target Neighborhood Hits	150	Shared Neighborhood Hits	69
SwissProt Accessions	P52479, Q91VY7	Gene names	Usp10, Ode-1, Uchrp
Domain Architecture
Description	Ubiquitin carboxyl-terminal hydrolase 10 (EC 3.1.2.15) (Ubiquitin thioesterase 10) (Ubiquitin-specific-processing protease 10) (Deubiquitinating enzyme 10).

UBP29_HUMAN
θ value	1.74796e-11 (rank : 45)	NC score	0.636404 (rank : 58)
Query Neighborhood Hits	101	Target Neighborhood Hits	94	Shared Neighborhood Hits	71
SwissProt Accessions	Q9HBJ7	Gene names	USP29
Domain Architecture
Description	Ubiquitin carboxyl-terminal hydrolase 29 (EC 3.1.2.15) (Ubiquitin thioesterase 29) (Ubiquitin-specific-processing protease 29) (Deubiquitinating enzyme 29).

SNUT2_HUMAN
θ value	8.67504e-11 (rank : 46)	NC score	0.691831 (rank : 53)
Query Neighborhood Hits	101	Target Neighborhood Hits	79	Shared Neighborhood Hits	59
SwissProt Accessions	Q53GS9, Q6NX47, Q96RK9, Q9BV89, Q9H381, Q9P050, Q9Y310	Gene names	USP39
Domain Architecture	No domain graphic available
Description	U4/U6.U5 tri-snRNP-associated protein 2 (U4/U6.U5 tri-snRNP-associated 65 kDa protein) (65K) (Inactive ubiquitin-specific peptidase 39) (SAD1 homolog).

SNUT2_MOUSE
θ value	1.47974e-10 (rank : 47)	NC score	0.703669 (rank : 48)
Query Neighborhood Hits	101	Target Neighborhood Hits	80	Shared Neighborhood Hits	60
SwissProt Accessions	Q3TIX9, Q3TI55, Q8BLI5, Q8BZZ5, Q9CQR1	Gene names	Usp39
Domain Architecture	No domain graphic available
Description	U4/U6.U5 tri-snRNP-associated protein 2 (Inactive ubiquitin-specific peptidase 39).

UBP18_HUMAN
θ value	1.47974e-10 (rank : 48)	NC score	0.802804 (rank : 35)
Query Neighborhood Hits	101	Target Neighborhood Hits	81	Shared Neighborhood Hits	72
SwissProt Accessions	Q9UMW8, Q9NY71	Gene names	USP18, ISG43
Domain Architecture
Description	Ubl carboxyl-terminal hydrolase 18 (EC 3.1.2.-) (Ubl thioesterase 18) (ISG15-specific-processing protease) (43 kDa ISG15-specific protease) (hUBP43).

UBP34_HUMAN
θ value	1.47974e-10 (rank : 49)	NC score	0.638242 (rank : 57)
Query Neighborhood Hits	101	Target Neighborhood Hits	210	Shared Neighborhood Hits	70
SwissProt Accessions	Q70CQ2, O60316, O94834, Q3B777, Q6P6C9, Q7L8P6, Q8N3T9, Q8TBW2, Q9UGA1	Gene names	USP34, KIAA0570, KIAA0729
Domain Architecture	No domain graphic available
Description	Ubiquitin carboxyl-terminal hydrolase 34 (EC 3.1.2.15) (Ubiquitin thioesterase 34) (Ubiquitin-specific-processing protease 34) (Deubiquitinating enzyme 34).

UBP26_HUMAN
θ value	1.9326e-10 (rank : 50)	NC score	0.616830 (rank : 60)
Query Neighborhood Hits	101	Target Neighborhood Hits	108	Shared Neighborhood Hits	69
SwissProt Accessions	Q9BXU7	Gene names	USP26
Domain Architecture
Description	Ubiquitin carboxyl-terminal hydrolase 26 (EC 3.1.2.15) (Ubiquitin thioesterase 26) (Ubiquitin-specific-processing protease 26) (Deubiquitinating enzyme 26).

UBP34_MOUSE
θ value	1.9326e-10 (rank : 51)	NC score	0.638605 (rank : 56)
Query Neighborhood Hits	101	Target Neighborhood Hits	189	Shared Neighborhood Hits	70
SwissProt Accessions	Q6ZQ93, Q3UPN0, Q6P563, Q7TMJ6, Q8CCH0	Gene names	Usp34, Kiaa0570
Domain Architecture	No domain graphic available
Description	Ubiquitin carboxyl-terminal hydrolase 34 (EC 3.1.2.15) (Ubiquitin thioesterase 34) (Ubiquitin-specific-processing protease 34) (Deubiquitinating enzyme 34).

UBP30_HUMAN
θ value	4.30538e-10 (rank : 52)	NC score	0.763595 (rank : 40)
Query Neighborhood Hits	101	Target Neighborhood Hits	94	Shared Neighborhood Hits	71
SwissProt Accessions	Q70CQ3, Q8WTU7, Q96JX4, Q9BSS3	Gene names	USP30
Domain Architecture	No domain graphic available
Description	Ubiquitin carboxyl-terminal hydrolase 30 (EC 3.1.2.15) (Ubiquitin thioesterase 30) (Ubiquitin-specific-processing protease 30) (Deubiquitinating enzyme 30).

UBP38_HUMAN
θ value	9.59137e-10 (rank : 53)	NC score	0.667867 (rank : 54)
Query Neighborhood Hits	101	Target Neighborhood Hits	97	Shared Neighborhood Hits	71
SwissProt Accessions	Q8NB14, Q8NDF5, Q96DK6, Q96PZ6, Q9BY55	Gene names	USP38, KIAA1891
Domain Architecture
Description	Ubiquitin carboxyl-terminal hydrolase 38 (EC 3.1.2.15) (Ubiquitin thioesterase 38) (Ubiquitin-specific-processing protease 38) (Deubiquitinating enzyme 38) (HP43.8KD).

UBP10_HUMAN
θ value	2.79066e-09 (rank : 54)	NC score	0.715843 (rank : 45)
Query Neighborhood Hits	101	Target Neighborhood Hits	153	Shared Neighborhood Hits	70
SwissProt Accessions	Q14694, Q9BWG7, Q9NSL7	Gene names	USP10, KIAA0190
Domain Architecture
Description	Ubiquitin carboxyl-terminal hydrolase 10 (EC 3.1.2.15) (Ubiquitin thioesterase 10) (Ubiquitin-specific-processing protease 10) (Deubiquitinating enzyme 10).

UBP7_HUMAN
θ value	2.79066e-09 (rank : 55)	NC score	0.707312 (rank : 47)
Query Neighborhood Hits	101	Target Neighborhood Hits	93	Shared Neighborhood Hits	70
SwissProt Accessions	Q93009	Gene names	USP7, HAUSP
Domain Architecture
Description	Ubiquitin carboxyl-terminal hydrolase 7 (EC 3.1.2.15) (Ubiquitin thioesterase 7) (Ubiquitin-specific-processing protease 7) (Deubiquitinating enzyme 7) (Herpesvirus-associated ubiquitin-specific protease).

UBP35_HUMAN
θ value	4.76016e-09 (rank : 56)	NC score	0.702540 (rank : 50)
Query Neighborhood Hits	101	Target Neighborhood Hits	223	Shared Neighborhood Hits	71
SwissProt Accessions	Q9P2H5	Gene names	USP35, KIAA1372, USP34
Domain Architecture
Description	Ubiquitin carboxyl-terminal hydrolase 35 (EC 3.1.2.15) (Ubiquitin thioesterase 35) (Ubiquitin-specific-processing protease 35) (Deubiquitinating enzyme 35).

UBP1_HUMAN
θ value	8.11959e-09 (rank : 57)	NC score	0.733858 (rank : 41)
Query Neighborhood Hits	101	Target Neighborhood Hits	259	Shared Neighborhood Hits	72
SwissProt Accessions	O94782, Q9UFR0, Q9UNJ3	Gene names	USP1
Domain Architecture
Description	Ubiquitin carboxyl-terminal hydrolase 1 (EC 3.1.2.15) (Ubiquitin thioesterase 1) (Ubiquitin-specific-processing protease 1) (Deubiquitinating enzyme 1) (hUBP).

UBP29_MOUSE
θ value	1.80886e-08 (rank : 58)	NC score	0.610428 (rank : 65)
Query Neighborhood Hits	101	Target Neighborhood Hits	95	Shared Neighborhood Hits	71
SwissProt Accessions	Q9ES63	Gene names	Usp29
Domain Architecture
Description	Ubiquitin carboxyl-terminal hydrolase 29 (EC 3.1.2.15) (Ubiquitin thioesterase 29) (Ubiquitin-specific-processing protease 29) (Deubiquitinating enzyme 29).

USP9X_MOUSE
θ value	5.26297e-08 (rank : 59)	NC score	0.610652 (rank : 64)
Query Neighborhood Hits	101	Target Neighborhood Hits	171	Shared Neighborhood Hits	74
SwissProt Accessions	P70398, Q62497	Gene names	Usp9x, Fafl, Fam
Domain Architecture
Description	Probable ubiquitin carboxyl-terminal hydrolase FAF-X (EC 3.1.2.15) (Ubiquitin thioesterase FAF-X) (Ubiquitin-specific-processing protease FAF-X) (Deubiquitinating enzyme FAF-X) (Fat facets protein-related, X- linked) (Ubiquitin-specific protease 9, X chromosome) (Ubiquitin carboxyl-terminal hydrolase FAM) (Fat facets homolog).

UBP38_MOUSE
θ value	8.97725e-08 (rank : 60)	NC score	0.663081 (rank : 55)
Query Neighborhood Hits	101	Target Neighborhood Hits	100	Shared Neighborhood Hits	71
SwissProt Accessions	Q8BW70, Q8BWL1, Q8BX03	Gene names	Usp38
Domain Architecture
Description	Ubiquitin carboxyl-terminal hydrolase 38 (EC 3.1.2.15) (Ubiquitin thioesterase 38) (Ubiquitin-specific-processing protease 38) (Deubiquitinating enzyme 38).

USP9Y_HUMAN
θ value	1.99992e-07 (rank : 61)	NC score	0.612577 (rank : 62)
Query Neighborhood Hits	101	Target Neighborhood Hits	109	Shared Neighborhood Hits	73
SwissProt Accessions	O00507, O14601	Gene names	USP9Y, DFFRY, USP10
Domain Architecture
Description	Probable ubiquitin carboxyl-terminal hydrolase FAF-Y (EC 3.1.2.15) (Ubiquitin thioesterase FAF-Y) (Ubiquitin-specific-processing protease FAF-Y) (Deubiquitinating enzyme FAF-Y) (Fat facets protein-related, Y- linked) (Ubiquitin-specific protease 9, Y chromosome).

USP9X_HUMAN
θ value	2.61198e-07 (rank : 62)	NC score	0.610692 (rank : 63)
Query Neighborhood Hits	101	Target Neighborhood Hits	161	Shared Neighborhood Hits	73
SwissProt Accessions	Q93008, O75550, Q8WWT3, Q8WX12	Gene names	USP9X, DFFRX, USP9
Domain Architecture
Description	Probable ubiquitin carboxyl-terminal hydrolase FAF-X (EC 3.1.2.15) (Ubiquitin thioesterase FAF-X) (Ubiquitin-specific-processing protease FAF-X) (Deubiquitinating enzyme FAF-X) (Fat facets protein-related, X- linked) (Ubiquitin-specific protease 9, X chromosome).

UBP13_HUMAN
θ value	5.81887e-07 (rank : 63)	NC score	0.541447 (rank : 68)
Query Neighborhood Hits	101	Target Neighborhood Hits	99	Shared Neighborhood Hits	72
SwissProt Accessions	Q92995	Gene names	USP13, ISOT3
Domain Architecture
Description	Ubiquitin carboxyl-terminal hydrolase 13 (EC 3.1.2.15) (Ubiquitin thioesterase 13) (Ubiquitin-specific-processing protease 13) (Deubiquitinating enzyme 13) (Isopeptidase T-3) (ISOT-3).

UBP5_HUMAN
θ value	5.81887e-07 (rank : 64)	NC score	0.548853 (rank : 66)
Query Neighborhood Hits	101	Target Neighborhood Hits	109	Shared Neighborhood Hits	73
SwissProt Accessions	P45974, Q96J22	Gene names	USP5, ISOT
Domain Architecture
Description	Ubiquitin carboxyl-terminal hydrolase 5 (EC 3.1.2.15) (Ubiquitin thioesterase 5) (Ubiquitin-specific-processing protease 5) (Deubiquitinating enzyme 5) (Isopeptidase T).

UBP5_MOUSE
θ value	2.88788e-06 (rank : 65)	NC score	0.543444 (rank : 67)
Query Neighborhood Hits	101	Target Neighborhood Hits	106	Shared Neighborhood Hits	73
SwissProt Accessions	P56399	Gene names	Usp5, Isot
Domain Architecture
Description	Ubiquitin carboxyl-terminal hydrolase 5 (EC 3.1.2.15) (Ubiquitin thioesterase 5) (Ubiquitin-specific-processing protease 5) (Deubiquitinating enzyme 5) (Isopeptidase T).

UBP14_MOUSE
θ value	4.1701e-05 (rank : 66)	NC score	0.615466 (rank : 61)
Query Neighborhood Hits	101	Target Neighborhood Hits	87	Shared Neighborhood Hits	70
SwissProt Accessions	Q9JMA1, Q543U5, Q923F2, Q9D0L0	Gene names	Usp14
Domain Architecture
Description	Ubiquitin carboxyl-terminal hydrolase 14 (EC 3.1.2.15) (Ubiquitin thioesterase 14) (Ubiquitin-specific-processing protease 14) (Deubiquitinating enzyme 14).

UBP40_HUMAN
θ value	4.1701e-05 (rank : 67)	NC score	0.699389 (rank : 51)
Query Neighborhood Hits	101	Target Neighborhood Hits	81	Shared Neighborhood Hits	71
SwissProt Accessions	Q9NVE5, Q6NX38, Q70EL0	Gene names	USP40
Domain Architecture	No domain graphic available
Description	Ubiquitin carboxyl-terminal hydrolase 40 (EC 3.1.2.15) (Ubiquitin thioesterase 40) (Ubiquitin-specific-processing protease 40) (Deubiquitinating enzyme 40).

UBP26_MOUSE
θ value	7.1131e-05 (rank : 68)	NC score	0.515304 (rank : 69)
Query Neighborhood Hits	101	Target Neighborhood Hits	107	Shared Neighborhood Hits	70
SwissProt Accessions	Q99MX1	Gene names	Usp26
Domain Architecture
Description	Ubiquitin carboxyl-terminal hydrolase 26 (EC 3.1.2.15) (Ubiquitin thioesterase 26) (Ubiquitin-specific-processing protease 26) (Deubiquitinating enzyme 26).

UBP14_HUMAN
θ value	0.000158464 (rank : 69)	NC score	0.628611 (rank : 59)
Query Neighborhood Hits	101	Target Neighborhood Hits	89	Shared Neighborhood Hits	71
SwissProt Accessions	P54578	Gene names	USP14, TGT
Domain Architecture
Description	Ubiquitin carboxyl-terminal hydrolase 14 (EC 3.1.2.15) (Ubiquitin thioesterase 14) (Ubiquitin-specific-processing protease 14) (Deubiquitinating enzyme 14).

SEM6B_HUMAN
θ value	0.0563607 (rank : 70)	NC score	0.015292 (rank : 88)
Query Neighborhood Hits	101	Target Neighborhood Hits	187	Shared Neighborhood Hits	4
SwissProt Accessions	Q9H3T3, Q9NRK9	Gene names	SEMA6B, SEMAZ
Domain Architecture
Description	Semaphorin-6B precursor (Semaphorin Z) (Sema Z).

SPEG_MOUSE
θ value	0.0563607 (rank : 71)	NC score	0.000091 (rank : 106)
Query Neighborhood Hits	101	Target Neighborhood Hits	1959	Shared Neighborhood Hits	16
SwissProt Accessions	Q62407, Q3TPH8, Q6P5V1, Q80TF7, Q80ZN0, Q8BZF4, Q9EQJ5	Gene names	Speg, Apeg1, Kiaa1297
Domain Architecture
Description	Striated muscle-specific serine/threonine protein kinase (EC 2.7.11.1) (Aortic preferentially expressed protein 1) (APEG-1).

UBP28_MOUSE
θ value	0.0961366 (rank : 72)	NC score	0.379954 (rank : 71)
Query Neighborhood Hits	101	Target Neighborhood Hits	178	Shared Neighborhood Hits	73
SwissProt Accessions	Q5I043, Q6NZP3, Q6ZPP1, Q8BWI1	Gene names	Usp28, Kiaa1515
Domain Architecture	No domain graphic available
Description	Ubiquitin carboxyl-terminal hydrolase 28 (EC 3.1.2.15) (Ubiquitin thioesterase 28) (Ubiquitin-specific-processing protease 28) (Deubiquitinating enzyme 28).

UBP28_HUMAN
θ value	0.125558 (rank : 73)	NC score	0.382653 (rank : 70)
Query Neighborhood Hits	101	Target Neighborhood Hits	117	Shared Neighborhood Hits	72
SwissProt Accessions	Q96RU2, Q9P213	Gene names	USP28, KIAA1515
Domain Architecture
Description	Ubiquitin carboxyl-terminal hydrolase 28 (EC 3.1.2.15) (Ubiquitin thioesterase 28) (Ubiquitin-specific-processing protease 28) (Deubiquitinating enzyme 28).

FA47A_HUMAN
θ value	0.21417 (rank : 74)	NC score	0.029271 (rank : 83)
Query Neighborhood Hits	101	Target Neighborhood Hits	451	Shared Neighborhood Hits	10
SwissProt Accessions	Q5JRC9, Q8TAA0	Gene names	FAM47A
Domain Architecture	No domain graphic available
Description	Protein FAM47A.

UBP25_HUMAN
θ value	0.21417 (rank : 75)	NC score	0.358713 (rank : 73)
Query Neighborhood Hits	101	Target Neighborhood Hits	124	Shared Neighborhood Hits	72
SwissProt Accessions	Q9UHP3, Q9H9W1	Gene names	USP25, USP21
Domain Architecture
Description	Ubiquitin carboxyl-terminal hydrolase 25 (EC 3.1.2.15) (Ubiquitin thioesterase 25) (Ubiquitin-specific-processing protease 25) (Deubiquitinating enzyme 25) (USP on chromosome 21).

UBP25_MOUSE
θ value	0.21417 (rank : 76)	NC score	0.360192 (rank : 72)
Query Neighborhood Hits	101	Target Neighborhood Hits	116	Shared Neighborhood Hits	73
SwissProt Accessions	P57080, Q80ZT9	Gene names	Usp25
Domain Architecture
Description	Ubiquitin carboxyl-terminal hydrolase 25 (EC 3.1.2.15) (Ubiquitin thioesterase 25) (Ubiquitin-specific-processing protease 25) (Deubiquitinating enzyme 25) (mUSP25).

PRRT3_HUMAN
θ value	0.279714 (rank : 77)	NC score	0.020683 (rank : 84)
Query Neighborhood Hits	101	Target Neighborhood Hits	998	Shared Neighborhood Hits	21
SwissProt Accessions	Q5FWE3, Q49AD0, Q6UXY6, Q8NBC9	Gene names	PRRT3, UNQ5823/PRO19642
Domain Architecture	No domain graphic available
Description	Proline-rich transmembrane protein 3.

ZN516_MOUSE
θ value	0.62314 (rank : 78)	NC score	-0.000884 (rank : 107)
Query Neighborhood Hits	101	Target Neighborhood Hits	1197	Shared Neighborhood Hits	13
SwissProt Accessions	Q7TSH3	Gene names	Znf516, Kiaa0222, Zfp516
Domain Architecture
Description	Zinc finger protein 516.

SSBP4_HUMAN
θ value	0.813845 (rank : 79)	NC score	0.015387 (rank : 87)
Query Neighborhood Hits	101	Target Neighborhood Hits	753	Shared Neighborhood Hits	12
SwissProt Accessions	Q9BWG4	Gene names	SSBP4
Domain Architecture
Description	Single-stranded DNA-binding protein 4.

TCGAP_HUMAN
θ value	1.06291 (rank : 80)	NC score	0.005991 (rank : 99)
Query Neighborhood Hits	101	Target Neighborhood Hits	872	Shared Neighborhood Hits	11
SwissProt Accessions	O14559, O14552, O14560, Q6ZSP6, Q96CP3, Q9NT23	Gene names	SNX26, TCGAP
Domain Architecture
Description	TC10/CDC42 GTPase-activating protein (Sorting nexin-26).

K1543_HUMAN
θ value	1.81305 (rank : 81)	NC score	0.016428 (rank : 86)
Query Neighborhood Hits	101	Target Neighborhood Hits	435	Shared Neighborhood Hits	10
SwissProt Accessions	Q9P1Y5, Q8NDF1	Gene names	KIAA1543
Domain Architecture	No domain graphic available
Description	Protein KIAA1543.

MAST4_HUMAN
θ value	1.81305 (rank : 82)	NC score	-0.002184 (rank : 110)
Query Neighborhood Hits	101	Target Neighborhood Hits	1804	Shared Neighborhood Hits	22
SwissProt Accessions	O15021, Q6ZN07, Q96LY3	Gene names	MAST4, KIAA0303
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase 4 (EC 2.7.11.1).

SON_HUMAN
θ value	1.81305 (rank : 83)	NC score	0.012498 (rank : 90)
Query Neighborhood Hits	101	Target Neighborhood Hits	1568	Shared Neighborhood Hits	19
SwissProt Accessions	P18583, O14487, O95981, Q14120, Q9H7B1, Q9P070, Q9P072, Q9UKP9, Q9UPY0	Gene names	SON, C21orf50, DBP5, KIAA1019, NREBP
Domain Architecture
Description	SON protein (SON3) (Negative regulatory element-binding protein) (NRE- binding protein) (DBP-5) (Bax antagonist selected in saccharomyces 1) (BASS1).

ASPP1_MOUSE
θ value	3.0926 (rank : 84)	NC score	0.006761 (rank : 97)
Query Neighborhood Hits	101	Target Neighborhood Hits	1244	Shared Neighborhood Hits	18
SwissProt Accessions	Q62415	Gene names	Ppp1r13b, Aspp1
Domain Architecture
Description	Apoptosis-stimulating of p53 protein 1 (Protein phosphatase 1 regulatory subunit 13B).

ATBF1_MOUSE
θ value	3.0926 (rank : 85)	NC score	-0.000909 (rank : 108)
Query Neighborhood Hits	101	Target Neighborhood Hits	1841	Shared Neighborhood Hits	19
SwissProt Accessions	Q61329	Gene names	Atbf1
Domain Architecture
Description	Alpha-fetoprotein enhancer-binding protein (AT motif-binding factor) (AT-binding transcription factor 1).

NCOA6_HUMAN
θ value	3.0926 (rank : 86)	NC score	0.011945 (rank : 92)
Query Neighborhood Hits	101	Target Neighborhood Hits	1202	Shared Neighborhood Hits	17
SwissProt Accessions	Q14686, Q9NTZ9, Q9UH74, Q9UK86	Gene names	NCOA6, AIB3, KIAA0181, RAP250, TRBP
Domain Architecture	No domain graphic available
Description	Nuclear receptor coactivator 6 (Amplified in breast cancer protein 3) (Cancer-amplified transcriptional coactivator ASC-2) (Activating signal cointegrator 2) (ASC-2) (Peroxisome proliferator-activated receptor-interacting protein) (PPAR-interacting protein) (PRIP) (Nuclear receptor-activating protein, 250 kDa) (Nuclear receptor coactivator RAP250) (NRC RAP250) (Thyroid hormone receptor-binding protein).

ATF6B_MOUSE
θ value	4.03905 (rank : 87)	NC score	0.008779 (rank : 95)
Query Neighborhood Hits	101	Target Neighborhood Hits	97	Shared Neighborhood Hits	2
SwissProt Accessions	O35451	Gene names	Crebl1
Domain Architecture
Description	Cyclic AMP-dependent transcription factor ATF-6 beta (Activating transcription factor 6 beta) (ATF6-beta) (cAMP-responsive element- binding protein-like 1) (cAMP response element-binding protein-related protein) (Creb-rp).

BLNK_MOUSE
θ value	5.27518 (rank : 88)	NC score	0.013506 (rank : 89)
Query Neighborhood Hits	101	Target Neighborhood Hits	296	Shared Neighborhood Hits	7
SwissProt Accessions	Q9QUN3, O88504	Gene names	Blnk, Bash, Ly57, Slp65
Domain Architecture	No domain graphic available
Description	B-cell linker protein (Cytoplasmic adapter protein) (B-cell adapter containing SH2 domain protein) (B-cell adapter containing Src homology 2 domain protein) (Src homology 2 domain-containing leukocyte protein of 65 kDa) (Slp-65) (Lymphocyte antigen 57).

NCOA6_MOUSE
θ value	5.27518 (rank : 89)	NC score	0.018856 (rank : 85)
Query Neighborhood Hits	101	Target Neighborhood Hits	1076	Shared Neighborhood Hits	19
SwissProt Accessions	Q9JL19, Q9JLT9	Gene names	Ncoa6, Aib3, Prip, Rap250, Trbp
Domain Architecture	No domain graphic available
Description	Nuclear receptor coactivator 6 (Amplified in breast cancer protein 3) (Cancer-amplified transcriptional coactivator ASC-2) (Activating signal cointegrator 2) (ASC-2) (Peroxisome proliferator-activated receptor-interacting protein) (PPAR-interacting protein) (Nuclear receptor-activating protein, 250 kDa) (Nuclear receptor coactivator RAP250) (NRC) (Thyroid hormone receptor-binding protein).

SCNNB_MOUSE
θ value	5.27518 (rank : 90)	NC score	0.004855 (rank : 102)
Query Neighborhood Hits	101	Target Neighborhood Hits	22	Shared Neighborhood Hits	2
SwissProt Accessions	Q9WU38	Gene names	Scnn1b
Domain Architecture
Description	Amiloride-sensitive sodium channel subunit beta (Epithelial Na+ channel subunit beta) (Beta ENaC) (Nonvoltage-gated sodium channel 1 subunit beta) (SCNEB) (Beta NaCH).

UB7I1_MOUSE
θ value	5.27518 (rank : 91)	NC score	0.008825 (rank : 94)
Query Neighborhood Hits	101	Target Neighborhood Hits	206	Shared Neighborhood Hits	8
SwissProt Accessions	P58283, Q3U493, Q3UE56, Q3UGM3, Q68FN0, Q6P1H8, Q6PWY5, Q8BN27, Q8C1U3	Gene names	Ubce7ip1, Triad3, Uip83, Zin
Domain Architecture	No domain graphic available
Description	E3 ubiquitin ligase TRIAD3 (EC 6.3.2.-) (Ubiquitin-conjugating enzyme 7-interacting protein 1) (UbcM4-interacting protein 83) (Triad domain- containing protein 3).

AAAS_MOUSE
θ value	6.88961 (rank : 92)	NC score	0.005039 (rank : 101)
Query Neighborhood Hits	101	Target Neighborhood Hits	144	Shared Neighborhood Hits	2
SwissProt Accessions	P58742, Q544M6	Gene names	Aaas
Domain Architecture
Description	Aladin (Adracalin).

CYLD_HUMAN
θ value	6.88961 (rank : 93)	NC score	0.012373 (rank : 91)
Query Neighborhood Hits	101	Target Neighborhood Hits	62	Shared Neighborhood Hits	4
SwissProt Accessions	Q9NQC7, O94934, Q7L3N6, Q96EH0, Q9NZX9	Gene names	CYLD, CYLD1, KIAA0849
Domain Architecture	No domain graphic available
Description	Probable ubiquitin carboxyl-terminal hydrolase CYLD (EC 3.1.2.15) (Ubiquitin thioesterase CYLD) (Ubiquitin-specific-processing protease CYLD) (Deubiquitinating enzyme CYLD).

ETV1_HUMAN
θ value	6.88961 (rank : 94)	NC score	0.003000 (rank : 103)
Query Neighborhood Hits	101	Target Neighborhood Hits	107	Shared Neighborhood Hits	4
SwissProt Accessions	P50549, O75849, Q9UQ71, Q9Y636	Gene names	ETV1, ER81
Domain Architecture
Description	ETS translocation variant 1 (ER81 protein).

INP5E_HUMAN
θ value	6.88961 (rank : 95)	NC score	0.007882 (rank : 96)
Query Neighborhood Hits	101	Target Neighborhood Hits	201	Shared Neighborhood Hits	7
SwissProt Accessions	Q9NRR6, Q15734	Gene names	INPP5E
Domain Architecture
Description	72 kDa inositol polyphosphate 5-phosphatase (EC 3.1.3.36) (Phosphatidylinositol-4,5-bisphosphate 5-phosphatase) (Phosphatidylinositol polyphosphate 5-phosphatase type IV).

SOX6_MOUSE
θ value	6.88961 (rank : 96)	NC score	0.002967 (rank : 104)
Query Neighborhood Hits	101	Target Neighborhood Hits	341	Shared Neighborhood Hits	5
SwissProt Accessions	P40645, Q62250, Q9QWS5	Gene names	Sox6, Sox-6
Domain Architecture
Description	Transcription factor SOX-6 (SOX-LZ).

CIDEA_HUMAN
θ value	8.99809 (rank : 97)	NC score	0.010095 (rank : 93)
Query Neighborhood Hits	101	Target Neighborhood Hits	11	Shared Neighborhood Hits	3
SwissProt Accessions	O60543	Gene names	CIDEA
Domain Architecture
Description	Cell death activator CIDE-A (Cell death-inducing DFFA-like effector A).

JHD2B_HUMAN
θ value	8.99809 (rank : 98)	NC score	0.006594 (rank : 98)
Query Neighborhood Hits	101	Target Neighborhood Hits	171	Shared Neighborhood Hits	5
SwissProt Accessions	Q7LBC6, Q9BVH6, Q9BW93, Q9BZ52, Q9NYF4, Q9UPS0	Gene names	JMJD1B, C5orf7, JHDM2B, KIAA1082
Domain Architecture	No domain graphic available
Description	JmjC domain-containing histone demethylation protein 2B (EC 1.14.11.-) (Jumonji domain-containing protein 1B) (Nuclear protein 5qNCA).

LRP1B_MOUSE
θ value	8.99809 (rank : 99)	NC score	-0.001627 (rank : 109)
Query Neighborhood Hits	101	Target Neighborhood Hits	606	Shared Neighborhood Hits	3
SwissProt Accessions	Q9JI18, Q8BZD3, Q8BZM7	Gene names	Lrp1b, Lrpdit
Domain Architecture
Description	Low-density lipoprotein receptor-related protein 1B precursor (Low- density lipoprotein receptor-related protein-deleted in tumor) (LRP- DIT).

P66A_MOUSE
θ value	8.99809 (rank : 100)	NC score	0.005123 (rank : 100)
Query Neighborhood Hits	101	Target Neighborhood Hits	58	Shared Neighborhood Hits	2
SwissProt Accessions	Q8CHY6, Q8BTQ2, Q8VEC9	Gene names	Gatad2a
Domain Architecture	No domain graphic available
Description	Transcriptional repressor p66 alpha (GATA zinc finger domain- containing protein 2A).

SOX6_HUMAN
θ value	8.99809 (rank : 101)	NC score	0.002725 (rank : 105)
Query Neighborhood Hits	101	Target Neighborhood Hits	332	Shared Neighborhood Hits	6
SwissProt Accessions	P35712, Q9BXQ3, Q9BXQ4, Q9BXQ5, Q9H0I8	Gene names	SOX6
Domain Architecture
Description	Transcription factor SOX-6.

BRAP_HUMAN
θ value	θ > 10 (rank : 102)	NC score	0.098874 (rank : 76)
Query Neighborhood Hits	101	Target Neighborhood Hits	560	Shared Neighborhood Hits	15
SwissProt Accessions	Q7Z569, O43238, O75341	Gene names	BRAP, RNF52
Domain Architecture	No domain graphic available
Description	BRCA1-associated protein (EC 6.3.2.-) (BRAP2) (Impedes mitogenic signal propagation) (IMP) (RING finger protein 52) (NY-REN-63 antigen).

BRAP_MOUSE
θ value	θ > 10 (rank : 103)	NC score	0.113346 (rank : 74)
Query Neighborhood Hits	101	Target Neighborhood Hits	409	Shared Neighborhood Hits	15
SwissProt Accessions	Q99MP8, Q8CC00, Q8CHX1, Q99MP7, Q9CXX8	Gene names	Brap
Domain Architecture	No domain graphic available
Description	BRCA1-associated protein (EC 6.3.2.-) (BRAP2) (Impedes mitogenic signal propagation) (IMP).

GGNB1_HUMAN
θ value	θ > 10 (rank : 104)	NC score	0.077054 (rank : 78)
Query Neighborhood Hits	101	Target Neighborhood Hits	10	Shared Neighborhood Hits	5
SwissProt Accessions	Q5YKI7, Q5YKI8	Gene names	GGNBP1
Domain Architecture	No domain graphic available
Description	Gametogenetin-binding protein 1.

GGNB1_MOUSE
θ value	θ > 10 (rank : 105)	NC score	0.101847 (rank : 75)
Query Neighborhood Hits	101	Target Neighborhood Hits	23	Shared Neighborhood Hits	5
SwissProt Accessions	Q6K1E7, Q8C5T9	Gene names	Ggnbp1
Domain Architecture	No domain graphic available
Description	Gametogenetin-binding protein 1.

HDAC6_HUMAN
θ value	θ > 10 (rank : 106)	NC score	0.072751 (rank : 79)
Query Neighborhood Hits	101	Target Neighborhood Hits	145	Shared Neighborhood Hits	15
SwissProt Accessions	Q9UBN7	Gene names	HDAC6
Domain Architecture
Description	Histone deacetylase 6 (HD6).

HDAC6_MOUSE
θ value	θ > 10 (rank : 107)	NC score	0.077262 (rank : 77)
Query Neighborhood Hits	101	Target Neighborhood Hits	88	Shared Neighborhood Hits	12
SwissProt Accessions	Q9Z2V5	Gene names	Hdac6
Domain Architecture
Description	Histone deacetylase 6 (HD6) (Histone deacetylase mHDA2).

TBCD3_HUMAN
θ value	θ > 10 (rank : 108)	NC score	0.061821 (rank : 80)
Query Neighborhood Hits	101	Target Neighborhood Hits	51	Shared Neighborhood Hits	2
SwissProt Accessions	Q8IZP1, Q9H0B9, Q9UDD4	Gene names	TBC1D3, PRC17
Domain Architecture
Description	TBC1 domain family member 3 (Rab GTPase-activating protein PRC17) (Prostate cancer gene 17 protein) (TRE17 alpha protein).

UBP54_HUMAN
θ value	θ > 10 (rank : 109)	NC score	0.053085 (rank : 82)
Query Neighborhood Hits	101	Target Neighborhood Hits	21	Shared Neighborhood Hits	14
SwissProt Accessions	Q70EL1, Q5F2F4	Gene names	USP54, C10orf29
Domain Architecture	No domain graphic available
Description	Inactive ubiquitin carboxyl-terminal hydrolase 54 (Inactive ubiquitin- specific peptidase 54).

UBP54_MOUSE
θ value	θ > 10 (rank : 110)	NC score	0.054569 (rank : 81)
Query Neighborhood Hits	101	Target Neighborhood Hits	19	Shared Neighborhood Hits	13
SwissProt Accessions	Q8BL06, Q8BZ28	Gene names	Usp54
Domain Architecture	No domain graphic available
Description	Inactive ubiquitin carboxyl-terminal hydrolase 54 (Inactive ubiquitin- specific peptidase 54).

Hits sorted by NC score

UBP21_MOUSE
NC score	0.999962 (rank : 1)	θ value	0 (rank : 2)
Query Neighborhood Hits	101	Target Neighborhood Hits	101	Shared Neighborhood Hits	101
SwissProt Accessions	Q9QZL6, Q9D0R1	Gene names	Usp21, Usp23
Domain Architecture
Description	Ubiquitin carboxyl-terminal hydrolase 21 (EC 3.1.2.15) (Ubiquitin thioesterase 21) (Ubiquitin-specific-processing protease 21) (Deubiquitinating enzyme 21).

UBP21_HUMAN
NC score	0.997941 (rank : 2)	θ value	0 (rank : 1)
Query Neighborhood Hits	101	Target Neighborhood Hits	95	Shared Neighborhood Hits	86
SwissProt Accessions	Q9UK80, Q9BTV1, Q9NYN4	Gene names	USP21, USP23
Domain Architecture
Description	Ubiquitin carboxyl-terminal hydrolase 21 (EC 3.1.2.15) (Ubiquitin thioesterase 21) (Ubiquitin-specific-processing protease 21) (Deubiquitinating enzyme 21) (NEDD8-specific protease).

UBP2_HUMAN
NC score	0.975969 (rank : 3)	θ value	4.49445e-92 (rank : 3)
Query Neighborhood Hits	101	Target Neighborhood Hits	84	Shared Neighborhood Hits	74
SwissProt Accessions	O75604, Q96MB9, Q9BQ21	Gene names	USP2, UBP41
Domain Architecture
Description	Ubiquitin carboxyl-terminal hydrolase 2 (EC 3.1.2.15) (Ubiquitin thioesterase 2) (Ubiquitin-specific-processing protease 2) (Deubiquitinating enzyme 2) (41 kDa ubiquitin-specific protease).

UBP2_MOUSE
NC score	0.975454 (rank : 4)	θ value	2.91321e-91 (rank : 4)
Query Neighborhood Hits	101	Target Neighborhood Hits	86	Shared Neighborhood Hits	74
SwissProt Accessions	O88623, Q6X4T9, Q6X4U1, Q8VD74, Q9JJ87	Gene names	Usp2, Ubp41
Domain Architecture
Description	Ubiquitin carboxyl-terminal hydrolase 2 (EC 3.1.2.15) (Ubiquitin thioesterase 2) (Ubiquitin-specific-processing protease 2) (Deubiquitinating enzyme 2) (41 kDa ubiquitin-specific protease).

UBP50_MOUSE
NC score	0.949177 (rank : 5)	θ value	1.73182e-43 (rank : 7)
Query Neighborhood Hits	101	Target Neighborhood Hits	80	Shared Neighborhood Hits	73
SwissProt Accessions	Q6P8X6, Q9D558, Q9D9E7	Gene names	Usp50
Domain Architecture	No domain graphic available
Description	Putative ubiquitin carboxyl-terminal hydrolase 50 (EC 3.1.2.15) (Ubiquitin thioesterase 50) (Ubiquitin-specific-processing protease 50) (Deubiquitinating enzyme 50).

UBP50_HUMAN
NC score	0.935920 (rank : 6)	θ value	2.77131e-33 (rank : 10)
Query Neighborhood Hits	101	Target Neighborhood Hits	75	Shared Neighborhood Hits	68
SwissProt Accessions	Q70EL3	Gene names	USP50
Domain Architecture	No domain graphic available
Description	Inactive ubiquitin carboxyl-terminal hydrolase 50 (Inactive ubiquitin- specific peptidase 50).

UBP3_MOUSE
NC score	0.931881 (rank : 7)	θ value	5.57106e-42 (rank : 8)
Query Neighborhood Hits	101	Target Neighborhood Hits	89	Shared Neighborhood Hits	73
SwissProt Accessions	Q91W36	Gene names	Usp3
Domain Architecture
Description	Ubiquitin carboxyl-terminal hydrolase 3 (EC 3.1.2.15) (Ubiquitin thioesterase 3) (Ubiquitin-specific-processing protease 3) (Deubiquitinating enzyme 3).

UBP8_MOUSE
NC score	0.927078 (rank : 8)	θ value	4.85792e-54 (rank : 6)
Query Neighborhood Hits	101	Target Neighborhood Hits	362	Shared Neighborhood Hits	75
SwissProt Accessions	Q80U87, Q80YP2, Q8R0D3, Q9EQU1, Q9WVP5	Gene names	Usp8, Kiaa0055, Ubpy
Domain Architecture
Description	Ubiquitin carboxyl-terminal hydrolase 8 (EC 3.1.2.15) (Ubiquitin thioesterase 8) (Ubiquitin-specific-processing protease 8) (Deubiquitinating enzyme 8) (mUBPy).

UBP3_HUMAN
NC score	0.924564 (rank : 9)	θ value	7.04741e-37 (rank : 9)
Query Neighborhood Hits	101	Target Neighborhood Hits	88	Shared Neighborhood Hits	73
SwissProt Accessions	Q9Y6I4	Gene names	USP3
Domain Architecture
Description	Ubiquitin carboxyl-terminal hydrolase 3 (EC 3.1.2.15) (Ubiquitin thioesterase 3) (Ubiquitin-specific-processing protease 3) (Deubiquitinating enzyme 3).

UBP22_MOUSE
NC score	0.906563 (rank : 10)	θ value	2.19584e-30 (rank : 12)
Query Neighborhood Hits	101	Target Neighborhood Hits	87	Shared Neighborhood Hits	73
SwissProt Accessions	Q5DU02, Q5SU81, Q66JV8	Gene names	Usp22, Kiaa1063
Domain Architecture	No domain graphic available
Description	Ubiquitin carboxyl-terminal hydrolase 22 (EC 3.1.2.15) (Ubiquitin thioesterase 22) (Ubiquitin-specific-processing protease 22) (Deubiquitinating enzyme 22).

UBP22_HUMAN
NC score	0.905688 (rank : 11)	θ value	6.38894e-30 (rank : 14)
Query Neighborhood Hits	101	Target Neighborhood Hits	87	Shared Neighborhood Hits	73
SwissProt Accessions	Q9UPT9	Gene names	USP22, KIAA1063, USP3L
Domain Architecture	No domain graphic available
Description	Ubiquitin carboxyl-terminal hydrolase 22 (EC 3.1.2.15) (Ubiquitin thioesterase 22) (Ubiquitin-specific-processing protease 22) (Deubiquitinating enzyme 22).

UBPW_MOUSE
NC score	0.904230 (rank : 12)	θ value	1.28732e-30 (rank : 11)
Query Neighborhood Hits	101	Target Neighborhood Hits	89	Shared Neighborhood Hits	73
SwissProt Accessions	Q61068	Gene names	Dub1, Dub-1
Domain Architecture
Description	Ubiquitin carboxyl-terminal hydrolase DUB-1 (EC 3.1.2.15) (Ubiquitin thioesterase DUB-1) (Ubiquitin-specific-processing protease DUB-1) (Deubiquitinating enzyme 1).

UBP51_HUMAN
NC score	0.898390 (rank : 13)	θ value	6.61148e-27 (rank : 22)
Query Neighborhood Hits	101	Target Neighborhood Hits	162	Shared Neighborhood Hits	76
SwissProt Accessions	Q70EK9, Q8IWJ8	Gene names	USP51
Domain Architecture	No domain graphic available
Description	Ubiquitin carboxyl-terminal hydrolase 51 (EC 3.1.2.15) (Ubiquitin thioesterase 51) (Ubiquitin-specific-processing protease 51) (Deubiquitinating enzyme 51).

UBP8_HUMAN
NC score	0.883610 (rank : 14)	θ value	1.66964e-54 (rank : 5)
Query Neighborhood Hits	101	Target Neighborhood Hits	751	Shared Neighborhood Hits	75
SwissProt Accessions	P40818, Q7Z3U2, Q86VA0, Q8IWI7	Gene names	USP8, KIAA0055, UBPY
Domain Architecture
Description	Ubiquitin carboxyl-terminal hydrolase 8 (EC 3.1.2.15) (Ubiquitin thioesterase 8) (Ubiquitin-specific-processing protease 8) (Deubiquitinating enzyme 8) (hUBPy).

UBP12_HUMAN
NC score	0.881374 (rank : 15)	θ value	2.35151e-24 (rank : 26)
Query Neighborhood Hits	101	Target Neighborhood Hits	85	Shared Neighborhood Hits	73
SwissProt Accessions	O75317	Gene names	USP12, UBH1, USP12L1
Domain Architecture
Description	Ubiquitin carboxyl-terminal hydrolase 12 (EC 3.1.2.15) (Ubiquitin thioesterase 12) (Ubiquitin-specific-processing protease 12) (Deubiquitinating enzyme 12) (Ubiquitin-hydrolyzing enzyme 1).

UBP46_HUMAN
NC score	0.875354 (rank : 16)	θ value	1.16704e-23 (rank : 28)
Query Neighborhood Hits	101	Target Neighborhood Hits	81	Shared Neighborhood Hits	73
SwissProt Accessions	P62068, Q80V95, Q9H7U4, Q9H9T8	Gene names	USP46
Domain Architecture
Description	Ubiquitin carboxyl-terminal hydrolase 46 (EC 3.1.2.15) (Ubiquitin thioesterase 46) (Ubiquitin-specific-processing protease 46) (Deubiquitinating enzyme 46).

UBP46_MOUSE
NC score	0.875354 (rank : 17)	θ value	1.16704e-23 (rank : 29)
Query Neighborhood Hits	101	Target Neighborhood Hits	81	Shared Neighborhood Hits	73
SwissProt Accessions	P62069, Q80V95, Q9H7U4, Q9H9T8	Gene names	Usp46
Domain Architecture
Description	Ubiquitin carboxyl-terminal hydrolase 46 (EC 3.1.2.15) (Ubiquitin thioesterase 46) (Ubiquitin-specific-processing protease 46) (Deubiquitinating enzyme 46).

UBP20_HUMAN
NC score	0.875259 (rank : 18)	θ value	6.84181e-24 (rank : 27)
Query Neighborhood Hits	101	Target Neighborhood Hits	113	Shared Neighborhood Hits	75
SwissProt Accessions	Q9Y2K6, Q96LG5, Q9UQN8, Q9UQP0	Gene names	USP20, KIAA1003, LSFR3A
Domain Architecture
Description	Ubiquitin carboxyl-terminal hydrolase 20 (EC 3.1.2.15) (Ubiquitin thioesterase 20) (Ubiquitin-specific-processing protease 20) (Deubiquitinating enzyme 20).

UBP33_HUMAN
NC score	0.873544 (rank : 19)	θ value	1.47289e-26 (rank : 23)
Query Neighborhood Hits	101	Target Neighborhood Hits	157	Shared Neighborhood Hits	73
SwissProt Accessions	Q8TEY7, Q8TEY6, Q96AV6, Q9H9F0, Q9UPQ5	Gene names	USP33, KIAA1097, VDU1
Domain Architecture
Description	Ubiquitin carboxyl-terminal hydrolase 33 (EC 3.1.2.15) (Ubiquitin thioesterase 33) (Ubiquitin-specific-processing protease 33) (Deubiquitinating enzyme 33) (VHL-interacting deubiquitinating enzyme 1).

UBP36_HUMAN
NC score	0.872762 (rank : 20)	θ value	2.19584e-30 (rank : 13)
Query Neighborhood Hits	101	Target Neighborhood Hits	232	Shared Neighborhood Hits	82
SwissProt Accessions	Q9P275, Q8NDM8, Q9NVC8	Gene names	USP36, KIAA1453
Domain Architecture
Description	Ubiquitin carboxyl-terminal hydrolase 36 (EC 3.1.2.15) (Ubiquitin thioesterase 36) (Ubiquitin-specific-processing protease 36) (Deubiquitinating enzyme 36).

UB17L_HUMAN
NC score	0.870303 (rank : 21)	θ value	9.87957e-23 (rank : 31)
Query Neighborhood Hits	101	Target Neighborhood Hits	83	Shared Neighborhood Hits	73
SwissProt Accessions	Q7RTZ2	Gene names	USP17L
Domain Architecture	No domain graphic available
Description	Ubiquitin carboxyl-terminal hydrolase 17-like protein (EC 3.1.2.15) (Ubiquitin thioesterase 17-like) (Ubiquitin-specific-processing protease 17-like) (Deubiquitinating enzyme 17-like).

UBP11_HUMAN
NC score	0.860314 (rank : 22)	θ value	1.24688e-25 (rank : 24)
Query Neighborhood Hits	101	Target Neighborhood Hits	88	Shared Neighborhood Hits	73
SwissProt Accessions	P51784, Q8IUG6, Q9BWE1	Gene names	USP11, UHX1
Domain Architecture
Description	Ubiquitin carboxyl-terminal hydrolase 11 (EC 3.1.2.15) (Ubiquitin thioesterase 11) (Ubiquitin-specific-processing protease 11) (Deubiquitinating enzyme 11).

UBP44_HUMAN
NC score	0.859918 (rank : 23)	θ value	3.39556e-23 (rank : 30)
Query Neighborhood Hits	101	Target Neighborhood Hits	91	Shared Neighborhood Hits	73
SwissProt Accessions	Q9H0E7	Gene names	USP44
Domain Architecture
Description	Ubiquitin carboxyl-terminal hydrolase 44 (EC 3.1.2.15) (Ubiquitin thioesterase 44) (Ubiquitin-specific-processing protease 44) (Deubiquitinating enzyme 44).

UBP15_MOUSE
NC score	0.854961 (rank : 24)	θ value	1.85889e-29 (rank : 16)
Query Neighborhood Hits	101	Target Neighborhood Hits	88	Shared Neighborhood Hits	73
SwissProt Accessions	Q8R5H1, Q3UL25	Gene names	Usp15
Domain Architecture
Description	Ubiquitin carboxyl-terminal hydrolase 15 (EC 3.1.2.15) (Ubiquitin thioesterase 15) (Ubiquitin-specific-processing protease 15) (Deubiquitinating enzyme 15).

UBP15_HUMAN
NC score	0.854493 (rank : 25)	θ value	1.85889e-29 (rank : 15)
Query Neighborhood Hits	101	Target Neighborhood Hits	92	Shared Neighborhood Hits	73
SwissProt Accessions	Q9Y4E8, Q9HCA6, Q9UNP0, Q9Y5B5	Gene names	USP15, KIAA0529
Domain Architecture
Description	Ubiquitin carboxyl-terminal hydrolase 15 (EC 3.1.2.15) (Ubiquitin thioesterase 15) (Ubiquitin-specific-processing protease 15) (Deubiquitinating enzyme 15) (Unph-2) (Unph4).

UBP4_HUMAN
NC score	0.852706 (rank : 26)	θ value	3.17079e-29 (rank : 17)
Query Neighborhood Hits	101	Target Neighborhood Hits	89	Shared Neighborhood Hits	73
SwissProt Accessions	Q13107, O43452, O43453	Gene names	USP4, UNP, UNPH
Domain Architecture
Description	Ubiquitin carboxyl-terminal hydrolase 4 (EC 3.1.2.15) (Ubiquitin thioesterase 4) (Ubiquitin-specific-processing protease 4) (Deubiquitinating enzyme 4) (Ubiquitous nuclear protein homolog).

UBP4_MOUSE
NC score	0.851403 (rank : 27)	θ value	7.80994e-28 (rank : 19)
Query Neighborhood Hits	101	Target Neighborhood Hits	90	Shared Neighborhood Hits	74
SwissProt Accessions	P35123, O54704	Gene names	Usp4, Unp
Domain Architecture
Description	Ubiquitin carboxyl-terminal hydrolase 4 (EC 3.1.2.15) (Ubiquitin thioesterase 4) (Ubiquitin-specific-processing protease 4) (Deubiquitinating enzyme 4) (Ubiquitous nuclear protein).

UBP49_MOUSE
NC score	0.850034 (rank : 28)	θ value	4.73814e-25 (rank : 25)
Query Neighborhood Hits	101	Target Neighborhood Hits	91	Shared Neighborhood Hits	74
SwissProt Accessions	Q6P9L4	Gene names	Usp49
Domain Architecture	No domain graphic available
Description	Ubiquitin carboxyl-terminal hydrolase 49 (EC 3.1.2.15) (Ubiquitin thioesterase 49) (Ubiquitin-specific-processing protease 49) (Deubiquitinating enzyme 49).

UBP42_HUMAN
NC score	0.847185 (rank : 29)	θ value	1.57365e-28 (rank : 18)
Query Neighborhood Hits	101	Target Neighborhood Hits	445	Shared Neighborhood Hits	76
SwissProt Accessions	Q9H9J4, Q3C166, Q6P9B4	Gene names	USP42
Domain Architecture	No domain graphic available
Description	Ubiquitin carboxyl-terminal hydrolase 42 (EC 3.1.2.15) (Ubiquitin thioesterase 42) (Ubiquitin-specific-processing protease 42) (Deubiquitinating enzyme 42).

UBP49_HUMAN
NC score	0.844907 (rank : 30)	θ value	1.86321e-21 (rank : 33)
Query Neighborhood Hits	101	Target Neighborhood Hits	100	Shared Neighborhood Hits	73
SwissProt Accessions	Q70CQ1, Q96CK4	Gene names	USP49
Domain Architecture	No domain graphic available
Description	Ubiquitin carboxyl-terminal hydrolase 49 (EC 3.1.2.15) (Ubiquitin thioesterase 49) (Ubiquitin-specific-processing protease 49) (Deubiquitinating enzyme 49).

UBP16_HUMAN
NC score	0.836403 (rank : 31)	θ value	2.69671e-12 (rank : 42)
Query Neighborhood Hits	101	Target Neighborhood Hits	126	Shared Neighborhood Hits	73
SwissProt Accessions	Q9Y5T5, Q8NEL3	Gene names	USP16
Domain Architecture
Description	Ubiquitin carboxyl-terminal hydrolase 16 (EC 3.1.2.15) (Ubiquitin thioesterase 16) (Ubiquitin-specific-processing protease 16) (Deubiquitinating enzyme 16) (Ubiquitin-processing protease UBP-M).

UBP43_MOUSE
NC score	0.830715 (rank : 32)	θ value	4.58923e-20 (rank : 34)
Query Neighborhood Hits	101	Target Neighborhood Hits	130	Shared Neighborhood Hits	74
SwissProt Accessions	Q8BUM9, Q8VDP5	Gene names	Usp43
Domain Architecture	No domain graphic available
Description	Ubiquitin carboxyl-terminal hydrolase 43 (EC 3.1.2.15) (Ubiquitin thioesterase 43) (Ubiquitin-specific-processing protease 43) (Deubiquitinating enzyme 43).

UBP43_HUMAN
NC score	0.829459 (rank : 33)	θ value	6.40375e-22 (rank : 32)
Query Neighborhood Hits	101	Target Neighborhood Hits	144	Shared Neighborhood Hits	75
SwissProt Accessions	Q70EL4, Q8N2C5, Q96DQ6	Gene names	USP43
Domain Architecture	No domain graphic available
Description	Ubiquitin carboxyl-terminal hydrolase 43 (EC 3.1.2.15) (Ubiquitin thioesterase 43) (Ubiquitin-specific-processing protease 43) (Deubiquitinating enzyme 43).

UBP31_HUMAN
NC score	0.815158 (rank : 34)	θ value	1.74391e-19 (rank : 35)
Query Neighborhood Hits	101	Target Neighborhood Hits	293	Shared Neighborhood Hits	77
SwissProt Accessions	Q70CQ4, Q6AW97, Q6ZTC0, Q6ZTN2, Q9ULL7	Gene names	USP31, KIAA1203
Domain Architecture	No domain graphic available
Description	Ubiquitin carboxyl-terminal hydrolase 31 (EC 3.1.2.15) (Ubiquitin thioesterase 31) (Ubiquitin-specific-processing protease 31) (Deubiquitinating enzyme 31).

UBP18_HUMAN
NC score	0.802804 (rank : 35)	θ value	1.47974e-10 (rank : 48)
Query Neighborhood Hits	101	Target Neighborhood Hits	81	Shared Neighborhood Hits	72
SwissProt Accessions	Q9UMW8, Q9NY71	Gene names	USP18, ISG43
Domain Architecture
Description	Ubl carboxyl-terminal hydrolase 18 (EC 3.1.2.-) (Ubl thioesterase 18) (ISG15-specific-processing protease) (43 kDa ISG15-specific protease) (hUBP43).

UBP18_MOUSE
NC score	0.791888 (rank : 36)	θ value	5.43371e-13 (rank : 41)
Query Neighborhood Hits	101	Target Neighborhood Hits	77	Shared Neighborhood Hits	70
SwissProt Accessions	Q9WTV6	Gene names	Usp18, Ubp43
Domain Architecture
Description	Ubl carboxyl-terminal hydrolase 18 (EC 3.1.2.-) (Ubl thioesterase 18) (ISG15-specific-processing protease) (43 kDa ISG15-specific protease).

UBP48_HUMAN
NC score	0.783654 (rank : 37)	θ value	6.20254e-17 (rank : 36)
Query Neighborhood Hits	101	Target Neighborhood Hits	101	Shared Neighborhood Hits	73
SwissProt Accessions	Q86UV5, Q2M3I4, Q5SZI4, Q5T3T5, Q6NX53, Q8N3F6, Q96F64, Q96IQ3, Q9H5N3, Q9H5T7, Q9NUJ6, Q9NXR0	Gene names	USP48
Domain Architecture	No domain graphic available
Description	Ubiquitin carboxyl-terminal hydrolase 48 (EC 3.1.2.15) (Ubiquitin thioesterase 48) (Ubiquitin-specific-processing protease 48) (Deubiquitinating enzyme 48).

UBP48_MOUSE
NC score	0.780714 (rank : 38)	θ value	1.058e-16 (rank : 37)
Query Neighborhood Hits	101	Target Neighborhood Hits	124	Shared Neighborhood Hits	73
SwissProt Accessions	Q3V0C5, Q3TM39, Q571J9, Q8VDJ1	Gene names	Usp48, Kiaa4202
Domain Architecture	No domain graphic available
Description	Ubiquitin carboxyl-terminal hydrolase 48 (EC 3.1.2.15) (Ubiquitin thioesterase 48) (Ubiquitin-specific-processing protease 48) (Deubiquitinating enzyme 48).

UBP32_HUMAN
NC score	0.769597 (rank : 39)	θ value	1.33217e-27 (rank : 20)
Query Neighborhood Hits	101	Target Neighborhood Hits	170	Shared Neighborhood Hits	74
SwissProt Accessions	Q8NFA0, Q9BX85, Q9Y591	Gene names	USP32, USP10
Domain Architecture
Description	Ubiquitin carboxyl-terminal hydrolase 32 (EC 3.1.2.15) (Ubiquitin thioesterase 32) (Ubiquitin-specific-processing protease 32) (Deubiquitinating enzyme 32) (NY-REN-60 antigen).

UBP30_HUMAN
NC score	0.763595 (rank : 40)	θ value	4.30538e-10 (rank : 52)
Query Neighborhood Hits	101	Target Neighborhood Hits	94	Shared Neighborhood Hits	71
SwissProt Accessions	Q70CQ3, Q8WTU7, Q96JX4, Q9BSS3	Gene names	USP30
Domain Architecture	No domain graphic available
Description	Ubiquitin carboxyl-terminal hydrolase 30 (EC 3.1.2.15) (Ubiquitin thioesterase 30) (Ubiquitin-specific-processing protease 30) (Deubiquitinating enzyme 30).

UBP1_HUMAN
NC score	0.733858 (rank : 41)	θ value	8.11959e-09 (rank : 57)
Query Neighborhood Hits	101	Target Neighborhood Hits	259	Shared Neighborhood Hits	72
SwissProt Accessions	O94782, Q9UFR0, Q9UNJ3	Gene names	USP1
Domain Architecture
Description	Ubiquitin carboxyl-terminal hydrolase 1 (EC 3.1.2.15) (Ubiquitin thioesterase 1) (Ubiquitin-specific-processing protease 1) (Deubiquitinating enzyme 1) (hUBP).

UBP6_HUMAN
NC score	0.727644 (rank : 42)	θ value	1.73987e-27 (rank : 21)
Query Neighborhood Hits	101	Target Neighborhood Hits	188	Shared Neighborhood Hits	75
SwissProt Accessions	P35125, Q15634, Q86WP6, Q8IWT4	Gene names	USP6, TRE2
Domain Architecture
Description	Ubiquitin carboxyl-terminal hydrolase 6 (EC 3.1.2.15) (Ubiquitin thioesterase 6) (Ubiquitin-specific-processing protease 6) (Deubiquitinating enzyme 6) (Proto-oncogene TRE-2).

UBP10_MOUSE
NC score	0.726307 (rank : 43)	θ value	7.84624e-12 (rank : 44)
Query Neighborhood Hits	101	Target Neighborhood Hits	150	Shared Neighborhood Hits	69
SwissProt Accessions	P52479, Q91VY7	Gene names	Usp10, Ode-1, Uchrp
Domain Architecture
Description	Ubiquitin carboxyl-terminal hydrolase 10 (EC 3.1.2.15) (Ubiquitin thioesterase 10) (Ubiquitin-specific-processing protease 10) (Deubiquitinating enzyme 10).

UBP24_HUMAN
NC score	0.718741 (rank : 44)	θ value	8.38298e-14 (rank : 39)
Query Neighborhood Hits	101	Target Neighborhood Hits	96	Shared Neighborhood Hits	71
SwissProt Accessions	Q9UPU5, Q6ZSY2, Q8N2Y4, Q9NXD1	Gene names	USP24, KIAA1057
Domain Architecture	No domain graphic available
Description	Ubiquitin carboxyl-terminal hydrolase 24 (EC 3.1.2.15) (Ubiquitin thioesterase 24) (Ubiquitin-specific-processing protease 24) (Deubiquitinating enzyme 24).

UBP10_HUMAN
NC score	0.715843 (rank : 45)	θ value	2.79066e-09 (rank : 54)
Query Neighborhood Hits	101	Target Neighborhood Hits	153	Shared Neighborhood Hits	70
SwissProt Accessions	Q14694, Q9BWG7, Q9NSL7	Gene names	USP10, KIAA0190
Domain Architecture
Description	Ubiquitin carboxyl-terminal hydrolase 10 (EC 3.1.2.15) (Ubiquitin thioesterase 10) (Ubiquitin-specific-processing protease 10) (Deubiquitinating enzyme 10).

UBP47_MOUSE
NC score	0.712680 (rank : 46)	θ value	7.58209e-15 (rank : 38)
Query Neighborhood Hits	101	Target Neighborhood Hits	135	Shared Neighborhood Hits	71
SwissProt Accessions	Q8BY87, Q5EBP2, Q6KAR9, Q80V06, Q8BHU1, Q8BI15, Q8BI16, Q8BUW4, Q91X25	Gene names	Usp47
Domain Architecture	No domain graphic available
Description	Ubiquitin carboxyl-terminal hydrolase 47 (EC 3.1.2.15) (Ubiquitin thioesterase 47) (Ubiquitin-specific-processing protease 47) (Deubiquitinating enzyme 47).

UBP7_HUMAN
NC score	0.707312 (rank : 47)	θ value	2.79066e-09 (rank : 55)
Query Neighborhood Hits	101	Target Neighborhood Hits	93	Shared Neighborhood Hits	70
SwissProt Accessions	Q93009	Gene names	USP7, HAUSP
Domain Architecture
Description	Ubiquitin carboxyl-terminal hydrolase 7 (EC 3.1.2.15) (Ubiquitin thioesterase 7) (Ubiquitin-specific-processing protease 7) (Deubiquitinating enzyme 7) (Herpesvirus-associated ubiquitin-specific protease).

SNUT2_MOUSE
NC score	0.703669 (rank : 48)	θ value	1.47974e-10 (rank : 47)
Query Neighborhood Hits	101	Target Neighborhood Hits	80	Shared Neighborhood Hits	60
SwissProt Accessions	Q3TIX9, Q3TI55, Q8BLI5, Q8BZZ5, Q9CQR1	Gene names	Usp39
Domain Architecture	No domain graphic available
Description	U4/U6.U5 tri-snRNP-associated protein 2 (Inactive ubiquitin-specific peptidase 39).

UBP47_HUMAN
NC score	0.702761 (rank : 49)	θ value	3.52202e-12 (rank : 43)
Query Neighborhood Hits	101	Target Neighborhood Hits	149	Shared Neighborhood Hits	71
SwissProt Accessions	Q96K76, Q658U0, Q86Y73, Q8TEP6, Q9BWI0, Q9NWN1	Gene names	USP47
Domain Architecture	No domain graphic available
Description	Ubiquitin carboxyl-terminal hydrolase 47 (EC 3.1.2.15) (Ubiquitin thioesterase 47) (Ubiquitin-specific-processing protease 47) (Deubiquitinating enzyme 47).

UBP35_HUMAN
NC score	0.702540 (rank : 50)	θ value	4.76016e-09 (rank : 56)
Query Neighborhood Hits	101	Target Neighborhood Hits	223	Shared Neighborhood Hits	71
SwissProt Accessions	Q9P2H5	Gene names	USP35, KIAA1372, USP34
Domain Architecture
Description	Ubiquitin carboxyl-terminal hydrolase 35 (EC 3.1.2.15) (Ubiquitin thioesterase 35) (Ubiquitin-specific-processing protease 35) (Deubiquitinating enzyme 35).

UBP40_HUMAN
NC score	0.699389 (rank : 51)	θ value	4.1701e-05 (rank : 67)
Query Neighborhood Hits	101	Target Neighborhood Hits	81	Shared Neighborhood Hits	71
SwissProt Accessions	Q9NVE5, Q6NX38, Q70EL0	Gene names	USP40
Domain Architecture	No domain graphic available
Description	Ubiquitin carboxyl-terminal hydrolase 40 (EC 3.1.2.15) (Ubiquitin thioesterase 40) (Ubiquitin-specific-processing protease 40) (Deubiquitinating enzyme 40).

UBP37_HUMAN
NC score	0.698041 (rank : 52)	θ value	4.16044e-13 (rank : 40)
Query Neighborhood Hits	101	Target Neighborhood Hits	208	Shared Neighborhood Hits	73
SwissProt Accessions	Q86T82, Q9HCH8	Gene names	USP37, KIAA1594
Domain Architecture
Description	Ubiquitin carboxyl-terminal hydrolase 37 (EC 3.1.2.15) (Ubiquitin thioesterase 37) (Ubiquitin-specific-processing protease 37) (Deubiquitinating enzyme 37).

SNUT2_HUMAN
NC score	0.691831 (rank : 53)	θ value	8.67504e-11 (rank : 46)
Query Neighborhood Hits	101	Target Neighborhood Hits	79	Shared Neighborhood Hits	59
SwissProt Accessions	Q53GS9, Q6NX47, Q96RK9, Q9BV89, Q9H381, Q9P050, Q9Y310	Gene names	USP39
Domain Architecture	No domain graphic available
Description	U4/U6.U5 tri-snRNP-associated protein 2 (U4/U6.U5 tri-snRNP-associated 65 kDa protein) (65K) (Inactive ubiquitin-specific peptidase 39) (SAD1 homolog).

UBP38_HUMAN
NC score	0.667867 (rank : 54)	θ value	9.59137e-10 (rank : 53)
Query Neighborhood Hits	101	Target Neighborhood Hits	97	Shared Neighborhood Hits	71
SwissProt Accessions	Q8NB14, Q8NDF5, Q96DK6, Q96PZ6, Q9BY55	Gene names	USP38, KIAA1891
Domain Architecture
Description	Ubiquitin carboxyl-terminal hydrolase 38 (EC 3.1.2.15) (Ubiquitin thioesterase 38) (Ubiquitin-specific-processing protease 38) (Deubiquitinating enzyme 38) (HP43.8KD).

UBP38_MOUSE
NC score	0.663081 (rank : 55)	θ value	8.97725e-08 (rank : 60)
Query Neighborhood Hits	101	Target Neighborhood Hits	100	Shared Neighborhood Hits	71
SwissProt Accessions	Q8BW70, Q8BWL1, Q8BX03	Gene names	Usp38
Domain Architecture
Description	Ubiquitin carboxyl-terminal hydrolase 38 (EC 3.1.2.15) (Ubiquitin thioesterase 38) (Ubiquitin-specific-processing protease 38) (Deubiquitinating enzyme 38).

UBP34_MOUSE
NC score	0.638605 (rank : 56)	θ value	1.9326e-10 (rank : 51)
Query Neighborhood Hits	101	Target Neighborhood Hits	189	Shared Neighborhood Hits	70
SwissProt Accessions	Q6ZQ93, Q3UPN0, Q6P563, Q7TMJ6, Q8CCH0	Gene names	Usp34, Kiaa0570
Domain Architecture	No domain graphic available
Description	Ubiquitin carboxyl-terminal hydrolase 34 (EC 3.1.2.15) (Ubiquitin thioesterase 34) (Ubiquitin-specific-processing protease 34) (Deubiquitinating enzyme 34).

UBP34_HUMAN
NC score	0.638242 (rank : 57)	θ value	1.47974e-10 (rank : 49)
Query Neighborhood Hits	101	Target Neighborhood Hits	210	Shared Neighborhood Hits	70
SwissProt Accessions	Q70CQ2, O60316, O94834, Q3B777, Q6P6C9, Q7L8P6, Q8N3T9, Q8TBW2, Q9UGA1	Gene names	USP34, KIAA0570, KIAA0729
Domain Architecture	No domain graphic available
Description	Ubiquitin carboxyl-terminal hydrolase 34 (EC 3.1.2.15) (Ubiquitin thioesterase 34) (Ubiquitin-specific-processing protease 34) (Deubiquitinating enzyme 34).

UBP29_HUMAN
NC score	0.636404 (rank : 58)	θ value	1.74796e-11 (rank : 45)
Query Neighborhood Hits	101	Target Neighborhood Hits	94	Shared Neighborhood Hits	71
SwissProt Accessions	Q9HBJ7	Gene names	USP29
Domain Architecture
Description	Ubiquitin carboxyl-terminal hydrolase 29 (EC 3.1.2.15) (Ubiquitin thioesterase 29) (Ubiquitin-specific-processing protease 29) (Deubiquitinating enzyme 29).

UBP14_HUMAN
NC score	0.628611 (rank : 59)	θ value	0.000158464 (rank : 69)
Query Neighborhood Hits	101	Target Neighborhood Hits	89	Shared Neighborhood Hits	71
SwissProt Accessions	P54578	Gene names	USP14, TGT
Domain Architecture
Description	Ubiquitin carboxyl-terminal hydrolase 14 (EC 3.1.2.15) (Ubiquitin thioesterase 14) (Ubiquitin-specific-processing protease 14) (Deubiquitinating enzyme 14).

UBP26_HUMAN
NC score	0.616830 (rank : 60)	θ value	1.9326e-10 (rank : 50)
Query Neighborhood Hits	101	Target Neighborhood Hits	108	Shared Neighborhood Hits	69
SwissProt Accessions	Q9BXU7	Gene names	USP26
Domain Architecture
Description	Ubiquitin carboxyl-terminal hydrolase 26 (EC 3.1.2.15) (Ubiquitin thioesterase 26) (Ubiquitin-specific-processing protease 26) (Deubiquitinating enzyme 26).

UBP14_MOUSE
NC score	0.615466 (rank : 61)	θ value	4.1701e-05 (rank : 66)
Query Neighborhood Hits	101	Target Neighborhood Hits	87	Shared Neighborhood Hits	70
SwissProt Accessions	Q9JMA1, Q543U5, Q923F2, Q9D0L0	Gene names	Usp14
Domain Architecture
Description	Ubiquitin carboxyl-terminal hydrolase 14 (EC 3.1.2.15) (Ubiquitin thioesterase 14) (Ubiquitin-specific-processing protease 14) (Deubiquitinating enzyme 14).

USP9Y_HUMAN
NC score	0.612577 (rank : 62)	θ value	1.99992e-07 (rank : 61)
Query Neighborhood Hits	101	Target Neighborhood Hits	109	Shared Neighborhood Hits	73
SwissProt Accessions	O00507, O14601	Gene names	USP9Y, DFFRY, USP10
Domain Architecture
Description	Probable ubiquitin carboxyl-terminal hydrolase FAF-Y (EC 3.1.2.15) (Ubiquitin thioesterase FAF-Y) (Ubiquitin-specific-processing protease FAF-Y) (Deubiquitinating enzyme FAF-Y) (Fat facets protein-related, Y- linked) (Ubiquitin-specific protease 9, Y chromosome).

USP9X_HUMAN
NC score	0.610692 (rank : 63)	θ value	2.61198e-07 (rank : 62)
Query Neighborhood Hits	101	Target Neighborhood Hits	161	Shared Neighborhood Hits	73
SwissProt Accessions	Q93008, O75550, Q8WWT3, Q8WX12	Gene names	USP9X, DFFRX, USP9
Domain Architecture
Description	Probable ubiquitin carboxyl-terminal hydrolase FAF-X (EC 3.1.2.15) (Ubiquitin thioesterase FAF-X) (Ubiquitin-specific-processing protease FAF-X) (Deubiquitinating enzyme FAF-X) (Fat facets protein-related, X- linked) (Ubiquitin-specific protease 9, X chromosome).

USP9X_MOUSE
NC score	0.610652 (rank : 64)	θ value	5.26297e-08 (rank : 59)
Query Neighborhood Hits	101	Target Neighborhood Hits	171	Shared Neighborhood Hits	74
SwissProt Accessions	P70398, Q62497	Gene names	Usp9x, Fafl, Fam
Domain Architecture
Description	Probable ubiquitin carboxyl-terminal hydrolase FAF-X (EC 3.1.2.15) (Ubiquitin thioesterase FAF-X) (Ubiquitin-specific-processing protease FAF-X) (Deubiquitinating enzyme FAF-X) (Fat facets protein-related, X- linked) (Ubiquitin-specific protease 9, X chromosome) (Ubiquitin carboxyl-terminal hydrolase FAM) (Fat facets homolog).

UBP29_MOUSE
NC score	0.610428 (rank : 65)	θ value	1.80886e-08 (rank : 58)
Query Neighborhood Hits	101	Target Neighborhood Hits	95	Shared Neighborhood Hits	71
SwissProt Accessions	Q9ES63	Gene names	Usp29
Domain Architecture
Description	Ubiquitin carboxyl-terminal hydrolase 29 (EC 3.1.2.15) (Ubiquitin thioesterase 29) (Ubiquitin-specific-processing protease 29) (Deubiquitinating enzyme 29).

UBP5_HUMAN
NC score	0.548853 (rank : 66)	θ value	5.81887e-07 (rank : 64)
Query Neighborhood Hits	101	Target Neighborhood Hits	109	Shared Neighborhood Hits	73
SwissProt Accessions	P45974, Q96J22	Gene names	USP5, ISOT
Domain Architecture
Description	Ubiquitin carboxyl-terminal hydrolase 5 (EC 3.1.2.15) (Ubiquitin thioesterase 5) (Ubiquitin-specific-processing protease 5) (Deubiquitinating enzyme 5) (Isopeptidase T).

UBP5_MOUSE
NC score	0.543444 (rank : 67)	θ value	2.88788e-06 (rank : 65)
Query Neighborhood Hits	101	Target Neighborhood Hits	106	Shared Neighborhood Hits	73
SwissProt Accessions	P56399	Gene names	Usp5, Isot
Domain Architecture
Description	Ubiquitin carboxyl-terminal hydrolase 5 (EC 3.1.2.15) (Ubiquitin thioesterase 5) (Ubiquitin-specific-processing protease 5) (Deubiquitinating enzyme 5) (Isopeptidase T).

UBP13_HUMAN
NC score	0.541447 (rank : 68)	θ value	5.81887e-07 (rank : 63)
Query Neighborhood Hits	101	Target Neighborhood Hits	99	Shared Neighborhood Hits	72
SwissProt Accessions	Q92995	Gene names	USP13, ISOT3
Domain Architecture
Description	Ubiquitin carboxyl-terminal hydrolase 13 (EC 3.1.2.15) (Ubiquitin thioesterase 13) (Ubiquitin-specific-processing protease 13) (Deubiquitinating enzyme 13) (Isopeptidase T-3) (ISOT-3).

UBP26_MOUSE
NC score	0.515304 (rank : 69)	θ value	7.1131e-05 (rank : 68)
Query Neighborhood Hits	101	Target Neighborhood Hits	107	Shared Neighborhood Hits	70
SwissProt Accessions	Q99MX1	Gene names	Usp26
Domain Architecture
Description	Ubiquitin carboxyl-terminal hydrolase 26 (EC 3.1.2.15) (Ubiquitin thioesterase 26) (Ubiquitin-specific-processing protease 26) (Deubiquitinating enzyme 26).

UBP28_HUMAN
NC score	0.382653 (rank : 70)	θ value	0.125558 (rank : 73)
Query Neighborhood Hits	101	Target Neighborhood Hits	117	Shared Neighborhood Hits	72
SwissProt Accessions	Q96RU2, Q9P213	Gene names	USP28, KIAA1515
Domain Architecture
Description	Ubiquitin carboxyl-terminal hydrolase 28 (EC 3.1.2.15) (Ubiquitin thioesterase 28) (Ubiquitin-specific-processing protease 28) (Deubiquitinating enzyme 28).

UBP28_MOUSE
NC score	0.379954 (rank : 71)	θ value	0.0961366 (rank : 72)
Query Neighborhood Hits	101	Target Neighborhood Hits	178	Shared Neighborhood Hits	73
SwissProt Accessions	Q5I043, Q6NZP3, Q6ZPP1, Q8BWI1	Gene names	Usp28, Kiaa1515
Domain Architecture	No domain graphic available
Description	Ubiquitin carboxyl-terminal hydrolase 28 (EC 3.1.2.15) (Ubiquitin thioesterase 28) (Ubiquitin-specific-processing protease 28) (Deubiquitinating enzyme 28).

UBP25_MOUSE
NC score	0.360192 (rank : 72)	θ value	0.21417 (rank : 76)
Query Neighborhood Hits	101	Target Neighborhood Hits	116	Shared Neighborhood Hits	73
SwissProt Accessions	P57080, Q80ZT9	Gene names	Usp25
Domain Architecture
Description	Ubiquitin carboxyl-terminal hydrolase 25 (EC 3.1.2.15) (Ubiquitin thioesterase 25) (Ubiquitin-specific-processing protease 25) (Deubiquitinating enzyme 25) (mUSP25).

UBP25_HUMAN
NC score	0.358713 (rank : 73)	θ value	0.21417 (rank : 75)
Query Neighborhood Hits	101	Target Neighborhood Hits	124	Shared Neighborhood Hits	72
SwissProt Accessions	Q9UHP3, Q9H9W1	Gene names	USP25, USP21
Domain Architecture
Description	Ubiquitin carboxyl-terminal hydrolase 25 (EC 3.1.2.15) (Ubiquitin thioesterase 25) (Ubiquitin-specific-processing protease 25) (Deubiquitinating enzyme 25) (USP on chromosome 21).

BRAP_MOUSE
NC score	0.113346 (rank : 74)	θ value	θ > 10 (rank : 103)
Query Neighborhood Hits	101	Target Neighborhood Hits	409	Shared Neighborhood Hits	15
SwissProt Accessions	Q99MP8, Q8CC00, Q8CHX1, Q99MP7, Q9CXX8	Gene names	Brap
Domain Architecture	No domain graphic available
Description	BRCA1-associated protein (EC 6.3.2.-) (BRAP2) (Impedes mitogenic signal propagation) (IMP).

GGNB1_MOUSE
NC score	0.101847 (rank : 75)	θ value	θ > 10 (rank : 105)
Query Neighborhood Hits	101	Target Neighborhood Hits	23	Shared Neighborhood Hits	5
SwissProt Accessions	Q6K1E7, Q8C5T9	Gene names	Ggnbp1
Domain Architecture	No domain graphic available
Description	Gametogenetin-binding protein 1.

BRAP_HUMAN
NC score	0.098874 (rank : 76)	θ value	θ > 10 (rank : 102)
Query Neighborhood Hits	101	Target Neighborhood Hits	560	Shared Neighborhood Hits	15
SwissProt Accessions	Q7Z569, O43238, O75341	Gene names	BRAP, RNF52
Domain Architecture	No domain graphic available
Description	BRCA1-associated protein (EC 6.3.2.-) (BRAP2) (Impedes mitogenic signal propagation) (IMP) (RING finger protein 52) (NY-REN-63 antigen).

HDAC6_MOUSE
NC score	0.077262 (rank : 77)	θ value	θ > 10 (rank : 107)
Query Neighborhood Hits	101	Target Neighborhood Hits	88	Shared Neighborhood Hits	12
SwissProt Accessions	Q9Z2V5	Gene names	Hdac6
Domain Architecture
Description	Histone deacetylase 6 (HD6) (Histone deacetylase mHDA2).

GGNB1_HUMAN
NC score	0.077054 (rank : 78)	θ value	θ > 10 (rank : 104)
Query Neighborhood Hits	101	Target Neighborhood Hits	10	Shared Neighborhood Hits	5
SwissProt Accessions	Q5YKI7, Q5YKI8	Gene names	GGNBP1
Domain Architecture	No domain graphic available
Description	Gametogenetin-binding protein 1.

HDAC6_HUMAN
NC score	0.072751 (rank : 79)	θ value	θ > 10 (rank : 106)
Query Neighborhood Hits	101	Target Neighborhood Hits	145	Shared Neighborhood Hits	15
SwissProt Accessions	Q9UBN7	Gene names	HDAC6
Domain Architecture
Description	Histone deacetylase 6 (HD6).

TBCD3_HUMAN
NC score	0.061821 (rank : 80)	θ value	θ > 10 (rank : 108)
Query Neighborhood Hits	101	Target Neighborhood Hits	51	Shared Neighborhood Hits	2
SwissProt Accessions	Q8IZP1, Q9H0B9, Q9UDD4	Gene names	TBC1D3, PRC17
Domain Architecture
Description	TBC1 domain family member 3 (Rab GTPase-activating protein PRC17) (Prostate cancer gene 17 protein) (TRE17 alpha protein).

UBP54_MOUSE
NC score	0.054569 (rank : 81)	θ value	θ > 10 (rank : 110)
Query Neighborhood Hits	101	Target Neighborhood Hits	19	Shared Neighborhood Hits	13
SwissProt Accessions	Q8BL06, Q8BZ28	Gene names	Usp54
Domain Architecture	No domain graphic available
Description	Inactive ubiquitin carboxyl-terminal hydrolase 54 (Inactive ubiquitin- specific peptidase 54).

UBP54_HUMAN
NC score	0.053085 (rank : 82)	θ value	θ > 10 (rank : 109)
Query Neighborhood Hits	101	Target Neighborhood Hits	21	Shared Neighborhood Hits	14
SwissProt Accessions	Q70EL1, Q5F2F4	Gene names	USP54, C10orf29
Domain Architecture	No domain graphic available
Description	Inactive ubiquitin carboxyl-terminal hydrolase 54 (Inactive ubiquitin- specific peptidase 54).

FA47A_HUMAN
NC score	0.029271 (rank : 83)	θ value	0.21417 (rank : 74)
Query Neighborhood Hits	101	Target Neighborhood Hits	451	Shared Neighborhood Hits	10
SwissProt Accessions	Q5JRC9, Q8TAA0	Gene names	FAM47A
Domain Architecture	No domain graphic available
Description	Protein FAM47A.

PRRT3_HUMAN
NC score	0.020683 (rank : 84)	θ value	0.279714 (rank : 77)
Query Neighborhood Hits	101	Target Neighborhood Hits	998	Shared Neighborhood Hits	21
SwissProt Accessions	Q5FWE3, Q49AD0, Q6UXY6, Q8NBC9	Gene names	PRRT3, UNQ5823/PRO19642
Domain Architecture	No domain graphic available
Description	Proline-rich transmembrane protein 3.

NCOA6_MOUSE
NC score	0.018856 (rank : 85)	θ value	5.27518 (rank : 89)
Query Neighborhood Hits	101	Target Neighborhood Hits	1076	Shared Neighborhood Hits	19
SwissProt Accessions	Q9JL19, Q9JLT9	Gene names	Ncoa6, Aib3, Prip, Rap250, Trbp
Domain Architecture	No domain graphic available
Description	Nuclear receptor coactivator 6 (Amplified in breast cancer protein 3) (Cancer-amplified transcriptional coactivator ASC-2) (Activating signal cointegrator 2) (ASC-2) (Peroxisome proliferator-activated receptor-interacting protein) (PPAR-interacting protein) (Nuclear receptor-activating protein, 250 kDa) (Nuclear receptor coactivator RAP250) (NRC) (Thyroid hormone receptor-binding protein).

K1543_HUMAN
NC score	0.016428 (rank : 86)	θ value	1.81305 (rank : 81)
Query Neighborhood Hits	101	Target Neighborhood Hits	435	Shared Neighborhood Hits	10
SwissProt Accessions	Q9P1Y5, Q8NDF1	Gene names	KIAA1543
Domain Architecture	No domain graphic available
Description	Protein KIAA1543.

SSBP4_HUMAN
NC score	0.015387 (rank : 87)	θ value	0.813845 (rank : 79)
Query Neighborhood Hits	101	Target Neighborhood Hits	753	Shared Neighborhood Hits	12
SwissProt Accessions	Q9BWG4	Gene names	SSBP4
Domain Architecture
Description	Single-stranded DNA-binding protein 4.

SEM6B_HUMAN
NC score	0.015292 (rank : 88)	θ value	0.0563607 (rank : 70)
Query Neighborhood Hits	101	Target Neighborhood Hits	187	Shared Neighborhood Hits	4
SwissProt Accessions	Q9H3T3, Q9NRK9	Gene names	SEMA6B, SEMAZ
Domain Architecture
Description	Semaphorin-6B precursor (Semaphorin Z) (Sema Z).

BLNK_MOUSE
NC score	0.013506 (rank : 89)	θ value	5.27518 (rank : 88)
Query Neighborhood Hits	101	Target Neighborhood Hits	296	Shared Neighborhood Hits	7
SwissProt Accessions	Q9QUN3, O88504	Gene names	Blnk, Bash, Ly57, Slp65
Domain Architecture	No domain graphic available
Description	B-cell linker protein (Cytoplasmic adapter protein) (B-cell adapter containing SH2 domain protein) (B-cell adapter containing Src homology 2 domain protein) (Src homology 2 domain-containing leukocyte protein of 65 kDa) (Slp-65) (Lymphocyte antigen 57).

SON_HUMAN
NC score	0.012498 (rank : 90)	θ value	1.81305 (rank : 83)
Query Neighborhood Hits	101	Target Neighborhood Hits	1568	Shared Neighborhood Hits	19
SwissProt Accessions	P18583, O14487, O95981, Q14120, Q9H7B1, Q9P070, Q9P072, Q9UKP9, Q9UPY0	Gene names	SON, C21orf50, DBP5, KIAA1019, NREBP
Domain Architecture
Description	SON protein (SON3) (Negative regulatory element-binding protein) (NRE- binding protein) (DBP-5) (Bax antagonist selected in saccharomyces 1) (BASS1).

CYLD_HUMAN
NC score	0.012373 (rank : 91)	θ value	6.88961 (rank : 93)
Query Neighborhood Hits	101	Target Neighborhood Hits	62	Shared Neighborhood Hits	4
SwissProt Accessions	Q9NQC7, O94934, Q7L3N6, Q96EH0, Q9NZX9	Gene names	CYLD, CYLD1, KIAA0849
Domain Architecture	No domain graphic available
Description	Probable ubiquitin carboxyl-terminal hydrolase CYLD (EC 3.1.2.15) (Ubiquitin thioesterase CYLD) (Ubiquitin-specific-processing protease CYLD) (Deubiquitinating enzyme CYLD).

NCOA6_HUMAN
NC score	0.011945 (rank : 92)	θ value	3.0926 (rank : 86)
Query Neighborhood Hits	101	Target Neighborhood Hits	1202	Shared Neighborhood Hits	17
SwissProt Accessions	Q14686, Q9NTZ9, Q9UH74, Q9UK86	Gene names	NCOA6, AIB3, KIAA0181, RAP250, TRBP
Domain Architecture	No domain graphic available
Description	Nuclear receptor coactivator 6 (Amplified in breast cancer protein 3) (Cancer-amplified transcriptional coactivator ASC-2) (Activating signal cointegrator 2) (ASC-2) (Peroxisome proliferator-activated receptor-interacting protein) (PPAR-interacting protein) (PRIP) (Nuclear receptor-activating protein, 250 kDa) (Nuclear receptor coactivator RAP250) (NRC RAP250) (Thyroid hormone receptor-binding protein).

CIDEA_HUMAN
NC score	0.010095 (rank : 93)	θ value	8.99809 (rank : 97)
Query Neighborhood Hits	101	Target Neighborhood Hits	11	Shared Neighborhood Hits	3
SwissProt Accessions	O60543	Gene names	CIDEA
Domain Architecture
Description	Cell death activator CIDE-A (Cell death-inducing DFFA-like effector A).

UB7I1_MOUSE
NC score	0.008825 (rank : 94)	θ value	5.27518 (rank : 91)
Query Neighborhood Hits	101	Target Neighborhood Hits	206	Shared Neighborhood Hits	8
SwissProt Accessions	P58283, Q3U493, Q3UE56, Q3UGM3, Q68FN0, Q6P1H8, Q6PWY5, Q8BN27, Q8C1U3	Gene names	Ubce7ip1, Triad3, Uip83, Zin
Domain Architecture	No domain graphic available
Description	E3 ubiquitin ligase TRIAD3 (EC 6.3.2.-) (Ubiquitin-conjugating enzyme 7-interacting protein 1) (UbcM4-interacting protein 83) (Triad domain- containing protein 3).

ATF6B_MOUSE
NC score	0.008779 (rank : 95)	θ value	4.03905 (rank : 87)
Query Neighborhood Hits	101	Target Neighborhood Hits	97	Shared Neighborhood Hits	2
SwissProt Accessions	O35451	Gene names	Crebl1
Domain Architecture
Description	Cyclic AMP-dependent transcription factor ATF-6 beta (Activating transcription factor 6 beta) (ATF6-beta) (cAMP-responsive element- binding protein-like 1) (cAMP response element-binding protein-related protein) (Creb-rp).

INP5E_HUMAN
NC score	0.007882 (rank : 96)	θ value	6.88961 (rank : 95)
Query Neighborhood Hits	101	Target Neighborhood Hits	201	Shared Neighborhood Hits	7
SwissProt Accessions	Q9NRR6, Q15734	Gene names	INPP5E
Domain Architecture
Description	72 kDa inositol polyphosphate 5-phosphatase (EC 3.1.3.36) (Phosphatidylinositol-4,5-bisphosphate 5-phosphatase) (Phosphatidylinositol polyphosphate 5-phosphatase type IV).

ASPP1_MOUSE
NC score	0.006761 (rank : 97)	θ value	3.0926 (rank : 84)
Query Neighborhood Hits	101	Target Neighborhood Hits	1244	Shared Neighborhood Hits	18
SwissProt Accessions	Q62415	Gene names	Ppp1r13b, Aspp1
Domain Architecture
Description	Apoptosis-stimulating of p53 protein 1 (Protein phosphatase 1 regulatory subunit 13B).

JHD2B_HUMAN
NC score	0.006594 (rank : 98)	θ value	8.99809 (rank : 98)
Query Neighborhood Hits	101	Target Neighborhood Hits	171	Shared Neighborhood Hits	5
SwissProt Accessions	Q7LBC6, Q9BVH6, Q9BW93, Q9BZ52, Q9NYF4, Q9UPS0	Gene names	JMJD1B, C5orf7, JHDM2B, KIAA1082
Domain Architecture	No domain graphic available
Description	JmjC domain-containing histone demethylation protein 2B (EC 1.14.11.-) (Jumonji domain-containing protein 1B) (Nuclear protein 5qNCA).

TCGAP_HUMAN
NC score	0.005991 (rank : 99)	θ value	1.06291 (rank : 80)
Query Neighborhood Hits	101	Target Neighborhood Hits	872	Shared Neighborhood Hits	11
SwissProt Accessions	O14559, O14552, O14560, Q6ZSP6, Q96CP3, Q9NT23	Gene names	SNX26, TCGAP
Domain Architecture
Description	TC10/CDC42 GTPase-activating protein (Sorting nexin-26).

P66A_MOUSE
NC score	0.005123 (rank : 100)	θ value	8.99809 (rank : 100)
Query Neighborhood Hits	101	Target Neighborhood Hits	58	Shared Neighborhood Hits	2
SwissProt Accessions	Q8CHY6, Q8BTQ2, Q8VEC9	Gene names	Gatad2a
Domain Architecture	No domain graphic available
Description	Transcriptional repressor p66 alpha (GATA zinc finger domain- containing protein 2A).

AAAS_MOUSE
NC score	0.005039 (rank : 101)	θ value	6.88961 (rank : 92)
Query Neighborhood Hits	101	Target Neighborhood Hits	144	Shared Neighborhood Hits	2
SwissProt Accessions	P58742, Q544M6	Gene names	Aaas
Domain Architecture
Description	Aladin (Adracalin).

SCNNB_MOUSE
NC score	0.004855 (rank : 102)	θ value	5.27518 (rank : 90)
Query Neighborhood Hits	101	Target Neighborhood Hits	22	Shared Neighborhood Hits	2
SwissProt Accessions	Q9WU38	Gene names	Scnn1b
Domain Architecture
Description	Amiloride-sensitive sodium channel subunit beta (Epithelial Na+ channel subunit beta) (Beta ENaC) (Nonvoltage-gated sodium channel 1 subunit beta) (SCNEB) (Beta NaCH).

ETV1_HUMAN
NC score	0.003000 (rank : 103)	θ value	6.88961 (rank : 94)
Query Neighborhood Hits	101	Target Neighborhood Hits	107	Shared Neighborhood Hits	4
SwissProt Accessions	P50549, O75849, Q9UQ71, Q9Y636	Gene names	ETV1, ER81
Domain Architecture
Description	ETS translocation variant 1 (ER81 protein).

SOX6_MOUSE
NC score	0.002967 (rank : 104)	θ value	6.88961 (rank : 96)
Query Neighborhood Hits	101	Target Neighborhood Hits	341	Shared Neighborhood Hits	5
SwissProt Accessions	P40645, Q62250, Q9QWS5	Gene names	Sox6, Sox-6
Domain Architecture
Description	Transcription factor SOX-6 (SOX-LZ).

SOX6_HUMAN
NC score	0.002725 (rank : 105)	θ value	8.99809 (rank : 101)
Query Neighborhood Hits	101	Target Neighborhood Hits	332	Shared Neighborhood Hits	6
SwissProt Accessions	P35712, Q9BXQ3, Q9BXQ4, Q9BXQ5, Q9H0I8	Gene names	SOX6
Domain Architecture
Description	Transcription factor SOX-6.

SPEG_MOUSE
NC score	0.000091 (rank : 106)	θ value	0.0563607 (rank : 71)
Query Neighborhood Hits	101	Target Neighborhood Hits	1959	Shared Neighborhood Hits	16
SwissProt Accessions	Q62407, Q3TPH8, Q6P5V1, Q80TF7, Q80ZN0, Q8BZF4, Q9EQJ5	Gene names	Speg, Apeg1, Kiaa1297
Domain Architecture
Description	Striated muscle-specific serine/threonine protein kinase (EC 2.7.11.1) (Aortic preferentially expressed protein 1) (APEG-1).

ZN516_MOUSE
NC score	-0.000884 (rank : 107)	θ value	0.62314 (rank : 78)
Query Neighborhood Hits	101	Target Neighborhood Hits	1197	Shared Neighborhood Hits	13
SwissProt Accessions	Q7TSH3	Gene names	Znf516, Kiaa0222, Zfp516
Domain Architecture
Description	Zinc finger protein 516.

ATBF1_MOUSE
NC score	-0.000909 (rank : 108)	θ value	3.0926 (rank : 85)
Query Neighborhood Hits	101	Target Neighborhood Hits	1841	Shared Neighborhood Hits	19
SwissProt Accessions	Q61329	Gene names	Atbf1
Domain Architecture
Description	Alpha-fetoprotein enhancer-binding protein (AT motif-binding factor) (AT-binding transcription factor 1).

LRP1B_MOUSE
NC score	-0.001627 (rank : 109)	θ value	8.99809 (rank : 99)
Query Neighborhood Hits	101	Target Neighborhood Hits	606	Shared Neighborhood Hits	3
SwissProt Accessions	Q9JI18, Q8BZD3, Q8BZM7	Gene names	Lrp1b, Lrpdit
Domain Architecture
Description	Low-density lipoprotein receptor-related protein 1B precursor (Low- density lipoprotein receptor-related protein-deleted in tumor) (LRP- DIT).

MAST4_HUMAN
NC score	-0.002184 (rank : 110)	θ value	1.81305 (rank : 82)
Query Neighborhood Hits	101	Target Neighborhood Hits	1804	Shared Neighborhood Hits	22
SwissProt Accessions	O15021, Q6ZN07, Q96LY3	Gene names	MAST4, KIAA0303
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase 4 (EC 2.7.11.1).