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Network neighborhood for query Sequence : ITPR2_HUMAN

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ITPR2_HUMAN
SwissProt Accessions	Q14571, O94773	Gene names	ITPR2
Domain Architecture
Description	Inositol 1,4,5-trisphosphate receptor type 2 (Type 2 inositol 1,4,5- trisphosphate receptor) (Type 2 InsP3 receptor) (IP3 receptor isoform 2) (InsP3R2).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

ITPR1_HUMAN
θ value	0 (rank : 1)	NC score	0.993064 (rank : 3)
Query Neighborhood Hits	74	Target Neighborhood Hits	90	Shared Neighborhood Hits	20
SwissProt Accessions	Q14643, Q14660, Q99897	Gene names	ITPR1, INSP3R1
Domain Architecture
Description	Inositol 1,4,5-trisphosphate receptor type 1 (Type 1 inositol 1,4,5- trisphosphate receptor) (Type 1 InsP3 receptor) (IP3 receptor isoform 1) (InsP3R1) (IP3R).

ITPR1_MOUSE
θ value	0 (rank : 2)	NC score	0.992587 (rank : 4)
Query Neighborhood Hits	74	Target Neighborhood Hits	99	Shared Neighborhood Hits	21
SwissProt Accessions	P11881, P20943, Q99LG5	Gene names	Itpr1, Insp3r, Pcd6, Pcp1
Domain Architecture
Description	Inositol 1,4,5-trisphosphate receptor type 1 (Type 1 inositol 1,4,5- trisphosphate receptor) (Type 1 InsP3 receptor) (IP3 receptor isoform 1) (InsP3R1) (Inositol 1,4,5-trisphosphate-binding protein P400) (Purkinje cell protein 1) (Protein PCD-6).

ITPR2_HUMAN
θ value	0 (rank : 3)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	74	Target Neighborhood Hits	74	Shared Neighborhood Hits	74
SwissProt Accessions	Q14571, O94773	Gene names	ITPR2
Domain Architecture
Description	Inositol 1,4,5-trisphosphate receptor type 2 (Type 2 inositol 1,4,5- trisphosphate receptor) (Type 2 InsP3 receptor) (IP3 receptor isoform 2) (InsP3R2).

ITPR2_MOUSE
θ value	0 (rank : 4)	NC score	0.998677 (rank : 2)
Query Neighborhood Hits	74	Target Neighborhood Hits	69	Shared Neighborhood Hits	52
SwissProt Accessions	Q9Z329, P70226, Q5DWM3, Q5DWM5, Q61744, Q8R3B0	Gene names	Itpr2, Itpr5
Domain Architecture	No domain graphic available
Description	Inositol 1,4,5-trisphosphate receptor type 2 (Type 2 inositol 1,4,5- trisphosphate receptor) (Type 2 InsP3 receptor) (IP3 receptor isoform 2) (InsP3R2) (Inositol 1,4,5-trisphosphate type V receptor).

ITPR3_HUMAN
θ value	0 (rank : 5)	NC score	0.990631 (rank : 6)
Query Neighborhood Hits	74	Target Neighborhood Hits	114	Shared Neighborhood Hits	19
SwissProt Accessions	Q14573, Q14649	Gene names	ITPR3
Domain Architecture
Description	Inositol 1,4,5-trisphosphate receptor type 3 (Type 3 inositol 1,4,5- trisphosphate receptor) (Type 3 InsP3 receptor) (IP3 receptor isoform 3) (InsP3R3).

ITPR3_MOUSE
θ value	0 (rank : 6)	NC score	0.991231 (rank : 5)
Query Neighborhood Hits	74	Target Neighborhood Hits	105	Shared Neighborhood Hits	19
SwissProt Accessions	P70227, Q5DWM4, Q8CED5, Q91Z08	Gene names	Itpr3
Domain Architecture	No domain graphic available
Description	Inositol 1,4,5-trisphosphate receptor type 3 (Type 3 inositol 1,4,5- trisphosphate receptor) (Type 3 InsP3 receptor) (IP3 receptor isoform 3) (InsP3R3).

RYR1_HUMAN
θ value	7.80994e-28 (rank : 7)	NC score	0.534861 (rank : 8)
Query Neighborhood Hits	74	Target Neighborhood Hits	303	Shared Neighborhood Hits	11
SwissProt Accessions	P21817, Q16314, Q16368, Q9NPK1, Q9P1U4	Gene names	RYR1, RYDR
Domain Architecture
Description	Ryanodine receptor 1 (Skeletal muscle-type ryanodine receptor) (RyR1) (RYR-1) (Skeletal muscle calcium release channel).

RYR3_HUMAN
θ value	1.33217e-27 (rank : 8)	NC score	0.541309 (rank : 7)
Query Neighborhood Hits	74	Target Neighborhood Hits	134	Shared Neighborhood Hits	10
SwissProt Accessions	Q15413, O15175, Q15412	Gene names	RYR3, HBRR
Domain Architecture
Description	Ryanodine receptor 3 (Brain-type ryanodine receptor) (RyR3) (RYR-3) (Brain ryanodine receptor-calcium release channel).

RYR2_HUMAN
θ value	1.12775e-26 (rank : 9)	NC score	0.530373 (rank : 9)
Query Neighborhood Hits	74	Target Neighborhood Hits	175	Shared Neighborhood Hits	12
SwissProt Accessions	Q92736, Q15411, Q546N8	Gene names	RYR2
Domain Architecture
Description	Ryanodine receptor 2 (Cardiac muscle-type ryanodine receptor) (RyR2) (RYR-2) (Cardiac muscle ryanodine receptor-calcium release channel) (hRYR-2).

GOGA4_HUMAN
θ value	0.0330416 (rank : 10)	NC score	0.028142 (rank : 16)
Query Neighborhood Hits	74	Target Neighborhood Hits	2034	Shared Neighborhood Hits	37
SwissProt Accessions	Q13439, Q13270, Q13654, Q14436	Gene names	GOLGA4
Domain Architecture
Description	Golgin subfamily A member 4 (Trans-Golgi p230) (256 kDa golgin) (Golgin-245) (Protein 72.1).

UBP16_HUMAN
θ value	0.279714 (rank : 11)	NC score	0.018489 (rank : 28)
Query Neighborhood Hits	74	Target Neighborhood Hits	126	Shared Neighborhood Hits	4
SwissProt Accessions	Q9Y5T5, Q8NEL3	Gene names	USP16
Domain Architecture
Description	Ubiquitin carboxyl-terminal hydrolase 16 (EC 3.1.2.15) (Ubiquitin thioesterase 16) (Ubiquitin-specific-processing protease 16) (Deubiquitinating enzyme 16) (Ubiquitin-processing protease UBP-M).

CJ118_MOUSE
θ value	0.365318 (rank : 12)	NC score	0.037665 (rank : 10)
Query Neighborhood Hits	74	Target Neighborhood Hits	1132	Shared Neighborhood Hits	36
SwissProt Accessions	Q8C9S4, Q6P3D6, Q8CJC0	Gene names	Otg1
Domain Architecture	No domain graphic available
Description	Protein C10orf118 homolog (Oocyte-testis gene 1 protein).

RABE1_HUMAN
θ value	0.365318 (rank : 13)	NC score	0.029617 (rank : 13)
Query Neighborhood Hits	74	Target Neighborhood Hits	1104	Shared Neighborhood Hits	34
SwissProt Accessions	Q15276, O95369, Q8IVX3	Gene names	RABEP1, RABPT5, RABPT5A
Domain Architecture
Description	Rab GTPase-binding effector protein 1 (Rabaptin-5) (Rabaptin-5alpha) (Rabaptin-4) (NY-REN-17 antigen).

RABE1_MOUSE
θ value	0.365318 (rank : 14)	NC score	0.027534 (rank : 17)
Query Neighborhood Hits	74	Target Neighborhood Hits	1105	Shared Neighborhood Hits	32
SwissProt Accessions	O35551, Q99L08, Q9CRP3, Q9EQF9, Q9JI94	Gene names	Rabep1, Rab5ep, Rabpt5, Rabpt5a
Domain Architecture
Description	Rab GTPase-binding effector protein 1 (Rabaptin-5) (Rabaptin-5alpha).

SMC2_HUMAN
θ value	0.47712 (rank : 15)	NC score	0.017736 (rank : 30)
Query Neighborhood Hits	74	Target Neighborhood Hits	1405	Shared Neighborhood Hits	32
SwissProt Accessions	O95347, Q9P1P2	Gene names	SMC2L1, CAPE, SMC2
Domain Architecture
Description	Structural maintenance of chromosome 2-like 1 protein (Chromosome- associated protein E) (hCAP-E) (XCAP-E homolog).

CP2AC_MOUSE
θ value	0.813845 (rank : 16)	NC score	0.010537 (rank : 45)
Query Neighborhood Hits	74	Target Neighborhood Hits	110	Shared Neighborhood Hits	4
SwissProt Accessions	P56593	Gene names	Cyp2a12
Domain Architecture	No domain graphic available
Description	Cytochrome P450 2A12 (EC 1.14.14.1) (CYPIIA12) (Steroid hormones 7- alpha-hydroxylase) (Testosterone 7-alpha-hydroxylase).

LRBA_HUMAN
θ value	0.813845 (rank : 17)	NC score	0.019212 (rank : 26)
Query Neighborhood Hits	74	Target Neighborhood Hits	196	Shared Neighborhood Hits	4
SwissProt Accessions	P50851, Q9H2U3, Q9H2U4	Gene names	LRBA, BGL, CDC4L, LBA
Domain Architecture
Description	Lipopolysaccharide-responsive and beige-like anchor protein (CDC4-like protein) (Beige-like protein).

ANR26_MOUSE
θ value	1.06291 (rank : 18)	NC score	0.018430 (rank : 29)
Query Neighborhood Hits	74	Target Neighborhood Hits	1554	Shared Neighborhood Hits	36
SwissProt Accessions	Q811D2, Q69ZS2, Q9CS61	Gene names	Ankrd26, Kiaa1074
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 26.

CJ118_HUMAN
θ value	1.06291 (rank : 19)	NC score	0.028305 (rank : 15)
Query Neighborhood Hits	74	Target Neighborhood Hits	937	Shared Neighborhood Hits	32
SwissProt Accessions	Q7Z3E2, Q2M2V6, Q6NS91, Q7RTP1, Q8N117, Q8N3G3, Q8N6C2, Q9NWA3	Gene names	C10orf118
Domain Architecture	No domain graphic available
Description	Protein C10orf118 (CTCL tumor antigen HD-CL-01/L14-2).

P2RY1_MOUSE
θ value	1.06291 (rank : 20)	NC score	0.005235 (rank : 68)
Query Neighborhood Hits	74	Target Neighborhood Hits	591	Shared Neighborhood Hits	4
SwissProt Accessions	P49650	Gene names	P2ry1
Domain Architecture
Description	P2Y purinoceptor 1 (ATP receptor) (P2Y1) (Purinergic receptor).

TRRAP_HUMAN
θ value	1.06291 (rank : 21)	NC score	0.032163 (rank : 11)
Query Neighborhood Hits	74	Target Neighborhood Hits	117	Shared Neighborhood Hits	6
SwissProt Accessions	Q9Y4A5, O75218, Q9Y631, Q9Y6H4	Gene names	TRRAP, PAF400
Domain Architecture
Description	Transformation/transcription domain-associated protein (350/400 kDa PCAF-associated factor) (PAF350/400) (STAF40) (Tra1 homolog).

GA45B_MOUSE
θ value	1.38821 (rank : 22)	NC score	0.028879 (rank : 14)
Query Neighborhood Hits	74	Target Neighborhood Hits	9	Shared Neighborhood Hits	3
SwissProt Accessions	P22339, Q3U342, Q9R106	Gene names	Gadd45b, Myd118
Domain Architecture
Description	Growth arrest and DNA-damage-inducible protein GADD45 beta (Negative growth-regulatory protein MyD118) (Myeloid differentiation primary response protein MyD118).

ADDA_MOUSE
θ value	1.81305 (rank : 23)	NC score	0.010598 (rank : 44)
Query Neighborhood Hits	74	Target Neighborhood Hits	198	Shared Neighborhood Hits	2
SwissProt Accessions	Q9QYC0, Q9JLE3	Gene names	Add1
Domain Architecture
Description	Alpha-adducin (Erythrocyte adducin subunit alpha).

TBCD1_MOUSE
θ value	1.81305 (rank : 24)	NC score	0.013574 (rank : 36)
Query Neighborhood Hits	74	Target Neighborhood Hits	241	Shared Neighborhood Hits	13
SwissProt Accessions	Q60949, Q80TJ9, Q923F8	Gene names	Tbc1d1, Kiaa1108, Tbc1
Domain Architecture
Description	TBC1 domain family member 1.

CEP72_MOUSE
θ value	2.36792 (rank : 25)	NC score	0.026049 (rank : 20)
Query Neighborhood Hits	74	Target Neighborhood Hits	381	Shared Neighborhood Hits	19
SwissProt Accessions	Q9D3R3, Q8BM53, Q9D0B7	Gene names	Cep72
Domain Architecture	No domain graphic available
Description	Centrosomal protein of 72 kDa (Cep72 protein).

CHD6_HUMAN
θ value	2.36792 (rank : 26)	NC score	0.008962 (rank : 51)
Query Neighborhood Hits	74	Target Neighborhood Hits	342	Shared Neighborhood Hits	11
SwissProt Accessions	Q8TD26, Q5JYQ0, Q5TGZ9, Q5TH00, Q5TH01, Q8IZR2, Q8WTY0, Q9H4H6, Q9H6D4, Q9NTT7, Q9P2L1	Gene names	CHD6, CHD5, KIAA1335, RIGB
Domain Architecture
Description	Chromodomain-helicase-DNA-binding protein 6 (EC 3.6.1.-) (ATP- dependent helicase CHD6) (CHD-6) (Radiation-induced gene B protein).

P2RY1_HUMAN
θ value	2.36792 (rank : 27)	NC score	0.002503 (rank : 70)
Query Neighborhood Hits	74	Target Neighborhood Hits	642	Shared Neighborhood Hits	4
SwissProt Accessions	P47900	Gene names	P2RY1
Domain Architecture
Description	P2Y purinoceptor 1 (ATP receptor) (P2Y1) (Purinergic receptor).

BPAEA_MOUSE
θ value	3.0926 (rank : 28)	NC score	0.020944 (rank : 22)
Query Neighborhood Hits	74	Target Neighborhood Hits	1480	Shared Neighborhood Hits	35
SwissProt Accessions	Q91ZU8, Q8K5D4	Gene names	Dst, Bpag1
Domain Architecture
Description	Bullous pemphigoid antigen 1, isoform 5 (BPA) (Hemidesmosomal plaque protein) (Dystonia musculorum protein) (Dystonin).

CP2A6_HUMAN
θ value	3.0926 (rank : 29)	NC score	0.007355 (rank : 58)
Query Neighborhood Hits	74	Target Neighborhood Hits	108	Shared Neighborhood Hits	4
SwissProt Accessions	P11509, P00190, P10890, Q16803, Q4VAT9, Q4VAU0, Q4VAU1, Q9H1Z7, Q9UK48	Gene names	CYP2A6
Domain Architecture
Description	Cytochrome P450 2A6 (EC 1.14.14.1) (CYPIIA6) (Coumarin 7-hydroxylase) (P450 IIA3) (CYP2A3) (P450(I)).

CTRO_HUMAN
θ value	3.0926 (rank : 30)	NC score	0.008530 (rank : 53)
Query Neighborhood Hits	74	Target Neighborhood Hits	2092	Shared Neighborhood Hits	34
SwissProt Accessions	O14578, Q6XUH8, Q86UQ9, Q9UPZ7	Gene names	CIT, KIAA0949, STK21
Domain Architecture	No domain graphic available
Description	Citron Rho-interacting kinase (EC 2.7.11.1) (CRIK) (Rho-interacting, serine/threonine-protein kinase 21).

CTRO_MOUSE
θ value	3.0926 (rank : 31)	NC score	0.007932 (rank : 55)
Query Neighborhood Hits	74	Target Neighborhood Hits	2344	Shared Neighborhood Hits	34
SwissProt Accessions	P49025, O88528, O88937, O88938, Q3UM99, Q8CIJ1	Gene names	Cit
Domain Architecture
Description	Citron Rho-interacting kinase (EC 2.7.11.1) (CRIK) (Rho-interacting, serine/threonine-protein kinase 21).

LRRC1_MOUSE
θ value	3.0926 (rank : 32)	NC score	0.007316 (rank : 59)
Query Neighborhood Hits	74	Target Neighborhood Hits	281	Shared Neighborhood Hits	6
SwissProt Accessions	Q80VQ1, Q3UI50, Q8BKR1, Q8BUS9	Gene names	Lrrc1
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 1.

S26A6_HUMAN
θ value	3.0926 (rank : 33)	NC score	0.012687 (rank : 38)
Query Neighborhood Hits	74	Target Neighborhood Hits	32	Shared Neighborhood Hits	3
SwissProt Accessions	Q9BXS9, Q96Q90	Gene names	SLC26A6
Domain Architecture
Description	Solute carrier family 26 member 6 (Pendrin-like protein 1) (Pendrin L1).

ANR18_HUMAN
θ value	4.03905 (rank : 34)	NC score	0.008621 (rank : 52)
Query Neighborhood Hits	74	Target Neighborhood Hits	1106	Shared Neighborhood Hits	26
SwissProt Accessions	Q8IVF6, Q7Z468	Gene names	ANKRD18A, KIAA2015
Domain Architecture
Description	Ankyrin repeat domain-containing protein 18A.

LRC45_MOUSE
θ value	4.03905 (rank : 35)	NC score	0.023196 (rank : 21)
Query Neighborhood Hits	74	Target Neighborhood Hits	959	Shared Neighborhood Hits	33
SwissProt Accessions	Q8CIM1, Q3U5Z2	Gene names	Lrrc45
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 45.

MIS12_HUMAN
θ value	4.03905 (rank : 36)	NC score	0.026654 (rank : 19)
Query Neighborhood Hits	74	Target Neighborhood Hits	52	Shared Neighborhood Hits	5
SwissProt Accessions	Q9H081, Q96N24	Gene names	MIS12
Domain Architecture	No domain graphic available
Description	Protein MIS12 homolog.

MYH14_MOUSE
θ value	4.03905 (rank : 37)	NC score	0.014689 (rank : 35)
Query Neighborhood Hits	74	Target Neighborhood Hits	1225	Shared Neighborhood Hits	34
SwissProt Accessions	Q6URW6, Q80V64, Q80ZE6	Gene names	Myh14
Domain Architecture	No domain graphic available
Description	Myosin-14 (Myosin heavy chain, nonmuscle IIc) (Nonmuscle myosin heavy chain IIc) (NMHC II-C).

UBR2_HUMAN
θ value	4.03905 (rank : 38)	NC score	0.008481 (rank : 54)
Query Neighborhood Hits	74	Target Neighborhood Hits	45	Shared Neighborhood Hits	3
SwissProt Accessions	Q8IWV8, O15057, Q4VXK2, Q5TFH6, Q6P2I2, Q6ZUD0	Gene names	UBR2, C6orf133, KIAA0349
Domain Architecture	No domain graphic available
Description	Ubiquitin-protein ligase E3 component N-recognin-2 (EC 6.-.-.-) (Ubiquitin-protein ligase E3-alpha-2) (Ubiquitin-protein ligase E3- alpha-II).

ANGP1_HUMAN
θ value	5.27518 (rank : 39)	NC score	0.007243 (rank : 60)
Query Neighborhood Hits	74	Target Neighborhood Hits	254	Shared Neighborhood Hits	16
SwissProt Accessions	Q15389	Gene names	ANGPT1, KIAA0003
Domain Architecture
Description	Angiopoietin-1 precursor (ANG-1).

ANGP1_MOUSE
θ value	5.27518 (rank : 40)	NC score	0.006842 (rank : 61)
Query Neighborhood Hits	74	Target Neighborhood Hits	252	Shared Neighborhood Hits	13
SwissProt Accessions	O08538	Gene names	Angpt1, Agpt
Domain Architecture
Description	Angiopoietin-1 precursor (ANG-1).

ASB17_MOUSE
θ value	5.27518 (rank : 41)	NC score	0.026708 (rank : 18)
Query Neighborhood Hits	74	Target Neighborhood Hits	10	Shared Neighborhood Hits	3
SwissProt Accessions	Q8VHP9, Q9CUF9	Gene names	Asb17
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and SOCS box protein 17 (ASB-17).

CASL_HUMAN
θ value	5.27518 (rank : 42)	NC score	0.010045 (rank : 47)
Query Neighborhood Hits	74	Target Neighborhood Hits	259	Shared Neighborhood Hits	5
SwissProt Accessions	Q14511	Gene names	NEDD9, CASL
Domain Architecture
Description	Enhancer of filamentation 1 (HEF1) (CRK-associated substrate-related protein) (CAS-L) (CasL) (p105) (Protein NEDD9) (NY-REN-12 antigen).

CCD41_MOUSE
θ value	5.27518 (rank : 43)	NC score	0.011696 (rank : 41)
Query Neighborhood Hits	74	Target Neighborhood Hits	1399	Shared Neighborhood Hits	31
SwissProt Accessions	Q9D5R3, Q3U7X7, Q3UX57, Q80VF0	Gene names	Ccdc41
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 41.

DYH11_HUMAN
θ value	5.27518 (rank : 44)	NC score	0.010077 (rank : 46)
Query Neighborhood Hits	74	Target Neighborhood Hits	234	Shared Neighborhood Hits	13
SwissProt Accessions	Q96DT5, Q9UJ82	Gene names	DNAH11
Domain Architecture
Description	Ciliary dynein heavy chain 11 (Axonemal beta dynein heavy chain 11).

ELMD1_HUMAN
θ value	5.27518 (rank : 45)	NC score	0.009709 (rank : 48)
Query Neighborhood Hits	74	Target Neighborhood Hits	8	Shared Neighborhood Hits	2
SwissProt Accessions	Q8N336, Q9NPW3	Gene names	ELMOD1
Domain Architecture	No domain graphic available
Description	ELMO domain-containing protein 1.

MYO5A_MOUSE
θ value	5.27518 (rank : 46)	NC score	0.010865 (rank : 43)
Query Neighborhood Hits	74	Target Neighborhood Hits	1117	Shared Neighborhood Hits	30
SwissProt Accessions	Q99104	Gene names	Myo5a, Dilute
Domain Architecture
Description	Myosin-5A (Myosin Va) (Dilute myosin heavy chain, non-muscle).

SC11A_MOUSE
θ value	5.27518 (rank : 47)	NC score	0.012083 (rank : 39)
Query Neighborhood Hits	74	Target Neighborhood Hits	116	Shared Neighborhood Hits	7
SwissProt Accessions	Q9R053, Q9JMD4	Gene names	Scn11a, Nan, Nat, Sns2
Domain Architecture	No domain graphic available
Description	Sodium channel protein type 11 subunit alpha (Sodium channel protein type XI subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.9) (Sensory neuron sodium channel 2) (NaN).

T3JAM_MOUSE
θ value	5.27518 (rank : 48)	NC score	0.019754 (rank : 25)
Query Neighborhood Hits	74	Target Neighborhood Hits	535	Shared Neighborhood Hits	24
SwissProt Accessions	Q8C0G2, Q8BY50, Q8K1Y9	Gene names	Traf3ip3, T3jam
Domain Architecture	No domain graphic available
Description	TRAF3-interacting JNK-activating modulator (TRAF3-interacting protein 3).

TTLL5_HUMAN
θ value	5.27518 (rank : 49)	NC score	0.016885 (rank : 32)
Query Neighborhood Hits	74	Target Neighborhood Hits	141	Shared Neighborhood Hits	4
SwissProt Accessions	Q6EMB2, Q9P1V5, Q9UPZ4	Gene names	TTLL5, KIAA0998, STAMP
Domain Architecture	No domain graphic available
Description	Tubulin--tyrosine ligase-like protein 5 (SRC1 and TIF2-associated modulatory protein).

VDP_MOUSE
θ value	5.27518 (rank : 50)	NC score	0.020722 (rank : 23)
Query Neighborhood Hits	74	Target Neighborhood Hits	469	Shared Neighborhood Hits	27
SwissProt Accessions	Q9Z1Z0, Q3T9L9, Q3TH58, Q3U1C7, Q3UMW6, Q91WE7, Q99JZ5	Gene names	Vdp
Domain Architecture	No domain graphic available
Description	General vesicular transport factor p115 (Transcytosis-associated protein) (TAP) (Vesicle docking protein).

C8AP2_MOUSE
θ value	6.88961 (rank : 51)	NC score	0.007479 (rank : 57)
Query Neighborhood Hits	74	Target Neighborhood Hits	405	Shared Neighborhood Hits	9
SwissProt Accessions	Q9WUF3, Q9CSW2	Gene names	Casp8ap2, Flash
Domain Architecture	No domain graphic available
Description	CASP8-associated protein 2 (FLICE-associated huge protein).

CEP63_HUMAN
θ value	6.88961 (rank : 52)	NC score	0.011744 (rank : 40)
Query Neighborhood Hits	74	Target Neighborhood Hits	1005	Shared Neighborhood Hits	30
SwissProt Accessions	Q96MT8, Q96CR0, Q9H8F5, Q9H8N0	Gene names	CEP63
Domain Architecture	No domain graphic available
Description	Centrosomal protein of 63 kDa (Cep63 protein).

DLG5_HUMAN
θ value	6.88961 (rank : 53)	NC score	0.017368 (rank : 31)
Query Neighborhood Hits	74	Target Neighborhood Hits	1088	Shared Neighborhood Hits	32
SwissProt Accessions	Q8TDM6, Q5T1H7, Q5T1H8, Q6DKG3, Q86WC0, Q8TDM7, Q9UE73, Q9Y4E3	Gene names	DLG5, KIAA0583, PDLG
Domain Architecture
Description	Discs large homolog 5 (Placenta and prostate DLG) (Discs large protein P-dlg).

EP15_HUMAN
θ value	6.88961 (rank : 54)	NC score	0.030734 (rank : 12)
Query Neighborhood Hits	74	Target Neighborhood Hits	1021	Shared Neighborhood Hits	33
SwissProt Accessions	P42566	Gene names	EPS15, AF1P
Domain Architecture
Description	Epidermal growth factor receptor substrate 15 (Protein Eps15) (AF-1p protein).

HIP1R_MOUSE
θ value	6.88961 (rank : 55)	NC score	0.018982 (rank : 27)
Query Neighborhood Hits	74	Target Neighborhood Hits	959	Shared Neighborhood Hits	31
SwissProt Accessions	Q9JKY5	Gene names	Hip1r
Domain Architecture
Description	Huntingtin-interacting protein 1-related protein (Hip1-related).

HOOK2_HUMAN
θ value	6.88961 (rank : 56)	NC score	0.009152 (rank : 50)
Query Neighborhood Hits	74	Target Neighborhood Hits	714	Shared Neighborhood Hits	23
SwissProt Accessions	Q96ED9, O60562	Gene names	HOOK2
Domain Architecture
Description	Hook homolog 2 (h-hook2) (hHK2).

LRRC1_HUMAN
θ value	6.88961 (rank : 57)	NC score	0.005235 (rank : 67)
Query Neighborhood Hits	74	Target Neighborhood Hits	282	Shared Neighborhood Hits	6
SwissProt Accessions	Q9BTT6, Q9HAC0, Q9NVF1	Gene names	LRRC1, LANO
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 1 (LAP and no PDZ protein) (LANO adapter protein).

PI3R6_HUMAN
θ value	6.88961 (rank : 58)	NC score	0.013506 (rank : 37)
Query Neighborhood Hits	74	Target Neighborhood Hits	16	Shared Neighborhood Hits	3
SwissProt Accessions	Q5UE93, Q658R3	Gene names	PIK3R6, C17orf38
Domain Architecture	No domain graphic available
Description	Phosphoinositide 3-kinase regulatory subunit 6 (Phosphoinositide 3- kinase gamma adapter protein of 87 kDa) (p87 PI3K adapter protein) (p87PIKAP).

SLIT2_MOUSE
θ value	6.88961 (rank : 59)	NC score	0.000140 (rank : 71)
Query Neighborhood Hits	74	Target Neighborhood Hits	684	Shared Neighborhood Hits	5
SwissProt Accessions	Q9R1B9, Q9Z166	Gene names	Slit2
Domain Architecture
Description	Slit homolog 2 protein precursor (Slit-2) [Contains: Slit homolog 2 protein N-product; Slit homolog 2 protein C-product].

SMC2_MOUSE
θ value	6.88961 (rank : 60)	NC score	0.015127 (rank : 34)
Query Neighborhood Hits	74	Target Neighborhood Hits	1131	Shared Neighborhood Hits	28
SwissProt Accessions	Q8CG48, Q61076, Q9CS17, Q9CSD8	Gene names	Smc2l1, Cape, Fin16, Smc2
Domain Architecture
Description	Structural maintenance of chromosome 2-like 1 protein (Chromosome- associated protein E) (XCAP-E homolog) (FGF-inducible protein 16).

TRPA1_MOUSE
θ value	6.88961 (rank : 61)	NC score	0.004320 (rank : 69)
Query Neighborhood Hits	74	Target Neighborhood Hits	343	Shared Neighborhood Hits	5
SwissProt Accessions	Q8BLA8	Gene names	Trpa1, Anktm1
Domain Architecture	No domain graphic available
Description	Transient receptor potential cation channel subfamily A member 1 (Ankyrin-like with transmembrane domains protein 1).

WDTC1_HUMAN
θ value	6.88961 (rank : 62)	NC score	0.005910 (rank : 64)
Query Neighborhood Hits	74	Target Neighborhood Hits	299	Shared Neighborhood Hits	3
SwissProt Accessions	Q8N5D0, Q9NV87, Q9UPW4	Gene names	WDTC1, KIAA1037
Domain Architecture
Description	WD and tetratricopeptide repeats protein 1.

CKAP2_MOUSE
θ value	8.99809 (rank : 63)	NC score	0.016413 (rank : 33)
Query Neighborhood Hits	74	Target Neighborhood Hits	63	Shared Neighborhood Hits	3
SwissProt Accessions	Q3V1H1, Q66LN2, Q8BSF0	Gene names	Ckap2
Domain Architecture	No domain graphic available
Description	Cytoskeleton-associated protein 2.

EMIL1_HUMAN
θ value	8.99809 (rank : 64)	NC score	0.006725 (rank : 63)
Query Neighborhood Hits	74	Target Neighborhood Hits	239	Shared Neighborhood Hits	8
SwissProt Accessions	Q9Y6C2, Q96G58, Q9UG76	Gene names	EMILIN1, EMI
Domain Architecture
Description	EMILIN-1 precursor (Elastin microfibril interface-located protein 1) (Elastin microfibril interfacer 1).

GAK_MOUSE
θ value	8.99809 (rank : 65)	NC score	0.000118 (rank : 72)
Query Neighborhood Hits	74	Target Neighborhood Hits	964	Shared Neighborhood Hits	5
SwissProt Accessions	Q99KY4, Q6P1I8, Q6P9S5, Q8BM74, Q8K0Q4	Gene names	Gak
Domain Architecture	No domain graphic available
Description	Cyclin G-associated kinase (EC 2.7.11.1).

HMMR_HUMAN
θ value	8.99809 (rank : 66)	NC score	0.011493 (rank : 42)
Query Neighborhood Hits	74	Target Neighborhood Hits	1082	Shared Neighborhood Hits	29
SwissProt Accessions	O75330, Q92767	Gene names	HMMR, IHABP, RHAMM
Domain Architecture
Description	Hyaluronan mediated motility receptor (Intracellular hyaluronic acid- binding protein) (Receptor for hyaluronan-mediated motility) (CD168 antigen).

KAD7_HUMAN
θ value	8.99809 (rank : 67)	NC score	0.020293 (rank : 24)
Query Neighborhood Hits	74	Target Neighborhood Hits	83	Shared Neighborhood Hits	7
SwissProt Accessions	Q96M32, Q8IYP6	Gene names	AK7
Domain Architecture
Description	Putative adenylate kinase 7 (EC 2.7.4.3).

MYO5A_HUMAN
θ value	8.99809 (rank : 68)	NC score	0.007850 (rank : 56)
Query Neighborhood Hits	74	Target Neighborhood Hits	1092	Shared Neighborhood Hits	29
SwissProt Accessions	Q9Y4I1, O60653, Q07902, Q16249, Q9UE30, Q9UE31	Gene names	MYO5A, MYH12
Domain Architecture
Description	Myosin-5A (Myosin Va) (Dilute myosin heavy chain, non-muscle) (Myosin heavy chain 12) (Myoxin).

O10W1_HUMAN
θ value	8.99809 (rank : 69)	NC score	-0.001739 (rank : 74)
Query Neighborhood Hits	74	Target Neighborhood Hits	711	Shared Neighborhood Hits	3
SwissProt Accessions	Q8NGF6, Q6UXQ2	Gene names	OR10W1
Domain Architecture	No domain graphic available
Description	Olfactory receptor 10W1 (Olfactory receptor OR11-236).

OL139_MOUSE
θ value	8.99809 (rank : 70)	NC score	-0.000524 (rank : 73)
Query Neighborhood Hits	74	Target Neighborhood Hits	736	Shared Neighborhood Hits	5
SwissProt Accessions	Q60891, Q8VGR1, Q9EPY8	Gene names	Olfr139, Mor255-2, Olfr1
Domain Architecture	No domain graphic available
Description	Olfactory receptor 139 (Olfactory receptor 1) (Olfactory receptor 255- 2) (Odorant receptor M5).

SMG1_MOUSE
θ value	8.99809 (rank : 71)	NC score	0.005899 (rank : 65)
Query Neighborhood Hits	74	Target Neighborhood Hits	212	Shared Neighborhood Hits	6
SwissProt Accessions	Q8BKX6, Q5DU42, Q6ZQC0, Q8BLU4, Q8BWJ5, Q8BXD3	Gene names	Smg1, Kiaa0421
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase SMG1 (EC 2.7.11.1) (SMG-1).

SYF2_MOUSE
θ value	8.99809 (rank : 72)	NC score	0.009381 (rank : 49)
Query Neighborhood Hits	74	Target Neighborhood Hits	48	Shared Neighborhood Hits	3
SwissProt Accessions	Q9D198	Gene names	Syf2, Cbpin, Gcipip
Domain Architecture	No domain graphic available
Description	Pre-mRNA-splicing factor SYF2 (CCNDBP1-interactor) (p29) (mp29).

TERF2_HUMAN
θ value	8.99809 (rank : 73)	NC score	0.006827 (rank : 62)
Query Neighborhood Hits	74	Target Neighborhood Hits	102	Shared Neighborhood Hits	2
SwissProt Accessions	Q15554	Gene names	TERF2, TRF2
Domain Architecture
Description	Telomeric repeat-binding factor 2 (TTAGGG repeat-binding factor 2) (Telomeric DNA-binding protein).

WDTC1_MOUSE
θ value	8.99809 (rank : 74)	NC score	0.005290 (rank : 66)
Query Neighborhood Hits	74	Target Neighborhood Hits	298	Shared Neighborhood Hits	3
SwissProt Accessions	Q80ZK9	Gene names	Wdtc1
Domain Architecture
Description	WD and tetratricopeptide repeats protein 1.

Hits sorted by NC score

ITPR2_HUMAN
NC score	0.999962 (rank : 1)	θ value	0 (rank : 3)
Query Neighborhood Hits	74	Target Neighborhood Hits	74	Shared Neighborhood Hits	74
SwissProt Accessions	Q14571, O94773	Gene names	ITPR2
Domain Architecture
Description	Inositol 1,4,5-trisphosphate receptor type 2 (Type 2 inositol 1,4,5- trisphosphate receptor) (Type 2 InsP3 receptor) (IP3 receptor isoform 2) (InsP3R2).

ITPR2_MOUSE
NC score	0.998677 (rank : 2)	θ value	0 (rank : 4)
Query Neighborhood Hits	74	Target Neighborhood Hits	69	Shared Neighborhood Hits	52
SwissProt Accessions	Q9Z329, P70226, Q5DWM3, Q5DWM5, Q61744, Q8R3B0	Gene names	Itpr2, Itpr5
Domain Architecture	No domain graphic available
Description	Inositol 1,4,5-trisphosphate receptor type 2 (Type 2 inositol 1,4,5- trisphosphate receptor) (Type 2 InsP3 receptor) (IP3 receptor isoform 2) (InsP3R2) (Inositol 1,4,5-trisphosphate type V receptor).

ITPR1_HUMAN
NC score	0.993064 (rank : 3)	θ value	0 (rank : 1)
Query Neighborhood Hits	74	Target Neighborhood Hits	90	Shared Neighborhood Hits	20
SwissProt Accessions	Q14643, Q14660, Q99897	Gene names	ITPR1, INSP3R1
Domain Architecture
Description	Inositol 1,4,5-trisphosphate receptor type 1 (Type 1 inositol 1,4,5- trisphosphate receptor) (Type 1 InsP3 receptor) (IP3 receptor isoform 1) (InsP3R1) (IP3R).

ITPR1_MOUSE
NC score	0.992587 (rank : 4)	θ value	0 (rank : 2)
Query Neighborhood Hits	74	Target Neighborhood Hits	99	Shared Neighborhood Hits	21
SwissProt Accessions	P11881, P20943, Q99LG5	Gene names	Itpr1, Insp3r, Pcd6, Pcp1
Domain Architecture
Description	Inositol 1,4,5-trisphosphate receptor type 1 (Type 1 inositol 1,4,5- trisphosphate receptor) (Type 1 InsP3 receptor) (IP3 receptor isoform 1) (InsP3R1) (Inositol 1,4,5-trisphosphate-binding protein P400) (Purkinje cell protein 1) (Protein PCD-6).

ITPR3_MOUSE
NC score	0.991231 (rank : 5)	θ value	0 (rank : 6)
Query Neighborhood Hits	74	Target Neighborhood Hits	105	Shared Neighborhood Hits	19
SwissProt Accessions	P70227, Q5DWM4, Q8CED5, Q91Z08	Gene names	Itpr3
Domain Architecture	No domain graphic available
Description	Inositol 1,4,5-trisphosphate receptor type 3 (Type 3 inositol 1,4,5- trisphosphate receptor) (Type 3 InsP3 receptor) (IP3 receptor isoform 3) (InsP3R3).

ITPR3_HUMAN
NC score	0.990631 (rank : 6)	θ value	0 (rank : 5)
Query Neighborhood Hits	74	Target Neighborhood Hits	114	Shared Neighborhood Hits	19
SwissProt Accessions	Q14573, Q14649	Gene names	ITPR3
Domain Architecture
Description	Inositol 1,4,5-trisphosphate receptor type 3 (Type 3 inositol 1,4,5- trisphosphate receptor) (Type 3 InsP3 receptor) (IP3 receptor isoform 3) (InsP3R3).

RYR3_HUMAN
NC score	0.541309 (rank : 7)	θ value	1.33217e-27 (rank : 8)
Query Neighborhood Hits	74	Target Neighborhood Hits	134	Shared Neighborhood Hits	10
SwissProt Accessions	Q15413, O15175, Q15412	Gene names	RYR3, HBRR
Domain Architecture
Description	Ryanodine receptor 3 (Brain-type ryanodine receptor) (RyR3) (RYR-3) (Brain ryanodine receptor-calcium release channel).

RYR1_HUMAN
NC score	0.534861 (rank : 8)	θ value	7.80994e-28 (rank : 7)
Query Neighborhood Hits	74	Target Neighborhood Hits	303	Shared Neighborhood Hits	11
SwissProt Accessions	P21817, Q16314, Q16368, Q9NPK1, Q9P1U4	Gene names	RYR1, RYDR
Domain Architecture
Description	Ryanodine receptor 1 (Skeletal muscle-type ryanodine receptor) (RyR1) (RYR-1) (Skeletal muscle calcium release channel).

RYR2_HUMAN
NC score	0.530373 (rank : 9)	θ value	1.12775e-26 (rank : 9)
Query Neighborhood Hits	74	Target Neighborhood Hits	175	Shared Neighborhood Hits	12
SwissProt Accessions	Q92736, Q15411, Q546N8	Gene names	RYR2
Domain Architecture
Description	Ryanodine receptor 2 (Cardiac muscle-type ryanodine receptor) (RyR2) (RYR-2) (Cardiac muscle ryanodine receptor-calcium release channel) (hRYR-2).

CJ118_MOUSE
NC score	0.037665 (rank : 10)	θ value	0.365318 (rank : 12)
Query Neighborhood Hits	74	Target Neighborhood Hits	1132	Shared Neighborhood Hits	36
SwissProt Accessions	Q8C9S4, Q6P3D6, Q8CJC0	Gene names	Otg1
Domain Architecture	No domain graphic available
Description	Protein C10orf118 homolog (Oocyte-testis gene 1 protein).

TRRAP_HUMAN
NC score	0.032163 (rank : 11)	θ value	1.06291 (rank : 21)
Query Neighborhood Hits	74	Target Neighborhood Hits	117	Shared Neighborhood Hits	6
SwissProt Accessions	Q9Y4A5, O75218, Q9Y631, Q9Y6H4	Gene names	TRRAP, PAF400
Domain Architecture
Description	Transformation/transcription domain-associated protein (350/400 kDa PCAF-associated factor) (PAF350/400) (STAF40) (Tra1 homolog).

EP15_HUMAN
NC score	0.030734 (rank : 12)	θ value	6.88961 (rank : 54)
Query Neighborhood Hits	74	Target Neighborhood Hits	1021	Shared Neighborhood Hits	33
SwissProt Accessions	P42566	Gene names	EPS15, AF1P
Domain Architecture
Description	Epidermal growth factor receptor substrate 15 (Protein Eps15) (AF-1p protein).

RABE1_HUMAN
NC score	0.029617 (rank : 13)	θ value	0.365318 (rank : 13)
Query Neighborhood Hits	74	Target Neighborhood Hits	1104	Shared Neighborhood Hits	34
SwissProt Accessions	Q15276, O95369, Q8IVX3	Gene names	RABEP1, RABPT5, RABPT5A
Domain Architecture
Description	Rab GTPase-binding effector protein 1 (Rabaptin-5) (Rabaptin-5alpha) (Rabaptin-4) (NY-REN-17 antigen).

GA45B_MOUSE
NC score	0.028879 (rank : 14)	θ value	1.38821 (rank : 22)
Query Neighborhood Hits	74	Target Neighborhood Hits	9	Shared Neighborhood Hits	3
SwissProt Accessions	P22339, Q3U342, Q9R106	Gene names	Gadd45b, Myd118
Domain Architecture
Description	Growth arrest and DNA-damage-inducible protein GADD45 beta (Negative growth-regulatory protein MyD118) (Myeloid differentiation primary response protein MyD118).

CJ118_HUMAN
NC score	0.028305 (rank : 15)	θ value	1.06291 (rank : 19)
Query Neighborhood Hits	74	Target Neighborhood Hits	937	Shared Neighborhood Hits	32
SwissProt Accessions	Q7Z3E2, Q2M2V6, Q6NS91, Q7RTP1, Q8N117, Q8N3G3, Q8N6C2, Q9NWA3	Gene names	C10orf118
Domain Architecture	No domain graphic available
Description	Protein C10orf118 (CTCL tumor antigen HD-CL-01/L14-2).

GOGA4_HUMAN
NC score	0.028142 (rank : 16)	θ value	0.0330416 (rank : 10)
Query Neighborhood Hits	74	Target Neighborhood Hits	2034	Shared Neighborhood Hits	37
SwissProt Accessions	Q13439, Q13270, Q13654, Q14436	Gene names	GOLGA4
Domain Architecture
Description	Golgin subfamily A member 4 (Trans-Golgi p230) (256 kDa golgin) (Golgin-245) (Protein 72.1).

RABE1_MOUSE
NC score	0.027534 (rank : 17)	θ value	0.365318 (rank : 14)
Query Neighborhood Hits	74	Target Neighborhood Hits	1105	Shared Neighborhood Hits	32
SwissProt Accessions	O35551, Q99L08, Q9CRP3, Q9EQF9, Q9JI94	Gene names	Rabep1, Rab5ep, Rabpt5, Rabpt5a
Domain Architecture
Description	Rab GTPase-binding effector protein 1 (Rabaptin-5) (Rabaptin-5alpha).

ASB17_MOUSE
NC score	0.026708 (rank : 18)	θ value	5.27518 (rank : 41)
Query Neighborhood Hits	74	Target Neighborhood Hits	10	Shared Neighborhood Hits	3
SwissProt Accessions	Q8VHP9, Q9CUF9	Gene names	Asb17
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and SOCS box protein 17 (ASB-17).

MIS12_HUMAN
NC score	0.026654 (rank : 19)	θ value	4.03905 (rank : 36)
Query Neighborhood Hits	74	Target Neighborhood Hits	52	Shared Neighborhood Hits	5
SwissProt Accessions	Q9H081, Q96N24	Gene names	MIS12
Domain Architecture	No domain graphic available
Description	Protein MIS12 homolog.

CEP72_MOUSE
NC score	0.026049 (rank : 20)	θ value	2.36792 (rank : 25)
Query Neighborhood Hits	74	Target Neighborhood Hits	381	Shared Neighborhood Hits	19
SwissProt Accessions	Q9D3R3, Q8BM53, Q9D0B7	Gene names	Cep72
Domain Architecture	No domain graphic available
Description	Centrosomal protein of 72 kDa (Cep72 protein).

LRC45_MOUSE
NC score	0.023196 (rank : 21)	θ value	4.03905 (rank : 35)
Query Neighborhood Hits	74	Target Neighborhood Hits	959	Shared Neighborhood Hits	33
SwissProt Accessions	Q8CIM1, Q3U5Z2	Gene names	Lrrc45
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 45.

BPAEA_MOUSE
NC score	0.020944 (rank : 22)	θ value	3.0926 (rank : 28)
Query Neighborhood Hits	74	Target Neighborhood Hits	1480	Shared Neighborhood Hits	35
SwissProt Accessions	Q91ZU8, Q8K5D4	Gene names	Dst, Bpag1
Domain Architecture
Description	Bullous pemphigoid antigen 1, isoform 5 (BPA) (Hemidesmosomal plaque protein) (Dystonia musculorum protein) (Dystonin).

VDP_MOUSE
NC score	0.020722 (rank : 23)	θ value	5.27518 (rank : 50)
Query Neighborhood Hits	74	Target Neighborhood Hits	469	Shared Neighborhood Hits	27
SwissProt Accessions	Q9Z1Z0, Q3T9L9, Q3TH58, Q3U1C7, Q3UMW6, Q91WE7, Q99JZ5	Gene names	Vdp
Domain Architecture	No domain graphic available
Description	General vesicular transport factor p115 (Transcytosis-associated protein) (TAP) (Vesicle docking protein).

KAD7_HUMAN
NC score	0.020293 (rank : 24)	θ value	8.99809 (rank : 67)
Query Neighborhood Hits	74	Target Neighborhood Hits	83	Shared Neighborhood Hits	7
SwissProt Accessions	Q96M32, Q8IYP6	Gene names	AK7
Domain Architecture
Description	Putative adenylate kinase 7 (EC 2.7.4.3).

T3JAM_MOUSE
NC score	0.019754 (rank : 25)	θ value	5.27518 (rank : 48)
Query Neighborhood Hits	74	Target Neighborhood Hits	535	Shared Neighborhood Hits	24
SwissProt Accessions	Q8C0G2, Q8BY50, Q8K1Y9	Gene names	Traf3ip3, T3jam
Domain Architecture	No domain graphic available
Description	TRAF3-interacting JNK-activating modulator (TRAF3-interacting protein 3).

LRBA_HUMAN
NC score	0.019212 (rank : 26)	θ value	0.813845 (rank : 17)
Query Neighborhood Hits	74	Target Neighborhood Hits	196	Shared Neighborhood Hits	4
SwissProt Accessions	P50851, Q9H2U3, Q9H2U4	Gene names	LRBA, BGL, CDC4L, LBA
Domain Architecture
Description	Lipopolysaccharide-responsive and beige-like anchor protein (CDC4-like protein) (Beige-like protein).

HIP1R_MOUSE
NC score	0.018982 (rank : 27)	θ value	6.88961 (rank : 55)
Query Neighborhood Hits	74	Target Neighborhood Hits	959	Shared Neighborhood Hits	31
SwissProt Accessions	Q9JKY5	Gene names	Hip1r
Domain Architecture
Description	Huntingtin-interacting protein 1-related protein (Hip1-related).

UBP16_HUMAN
NC score	0.018489 (rank : 28)	θ value	0.279714 (rank : 11)
Query Neighborhood Hits	74	Target Neighborhood Hits	126	Shared Neighborhood Hits	4
SwissProt Accessions	Q9Y5T5, Q8NEL3	Gene names	USP16
Domain Architecture
Description	Ubiquitin carboxyl-terminal hydrolase 16 (EC 3.1.2.15) (Ubiquitin thioesterase 16) (Ubiquitin-specific-processing protease 16) (Deubiquitinating enzyme 16) (Ubiquitin-processing protease UBP-M).

ANR26_MOUSE
NC score	0.018430 (rank : 29)	θ value	1.06291 (rank : 18)
Query Neighborhood Hits	74	Target Neighborhood Hits	1554	Shared Neighborhood Hits	36
SwissProt Accessions	Q811D2, Q69ZS2, Q9CS61	Gene names	Ankrd26, Kiaa1074
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 26.

SMC2_HUMAN
NC score	0.017736 (rank : 30)	θ value	0.47712 (rank : 15)
Query Neighborhood Hits	74	Target Neighborhood Hits	1405	Shared Neighborhood Hits	32
SwissProt Accessions	O95347, Q9P1P2	Gene names	SMC2L1, CAPE, SMC2
Domain Architecture
Description	Structural maintenance of chromosome 2-like 1 protein (Chromosome- associated protein E) (hCAP-E) (XCAP-E homolog).

DLG5_HUMAN
NC score	0.017368 (rank : 31)	θ value	6.88961 (rank : 53)
Query Neighborhood Hits	74	Target Neighborhood Hits	1088	Shared Neighborhood Hits	32
SwissProt Accessions	Q8TDM6, Q5T1H7, Q5T1H8, Q6DKG3, Q86WC0, Q8TDM7, Q9UE73, Q9Y4E3	Gene names	DLG5, KIAA0583, PDLG
Domain Architecture
Description	Discs large homolog 5 (Placenta and prostate DLG) (Discs large protein P-dlg).

TTLL5_HUMAN
NC score	0.016885 (rank : 32)	θ value	5.27518 (rank : 49)
Query Neighborhood Hits	74	Target Neighborhood Hits	141	Shared Neighborhood Hits	4
SwissProt Accessions	Q6EMB2, Q9P1V5, Q9UPZ4	Gene names	TTLL5, KIAA0998, STAMP
Domain Architecture	No domain graphic available
Description	Tubulin--tyrosine ligase-like protein 5 (SRC1 and TIF2-associated modulatory protein).

CKAP2_MOUSE
NC score	0.016413 (rank : 33)	θ value	8.99809 (rank : 63)
Query Neighborhood Hits	74	Target Neighborhood Hits	63	Shared Neighborhood Hits	3
SwissProt Accessions	Q3V1H1, Q66LN2, Q8BSF0	Gene names	Ckap2
Domain Architecture	No domain graphic available
Description	Cytoskeleton-associated protein 2.

SMC2_MOUSE
NC score	0.015127 (rank : 34)	θ value	6.88961 (rank : 60)
Query Neighborhood Hits	74	Target Neighborhood Hits	1131	Shared Neighborhood Hits	28
SwissProt Accessions	Q8CG48, Q61076, Q9CS17, Q9CSD8	Gene names	Smc2l1, Cape, Fin16, Smc2
Domain Architecture
Description	Structural maintenance of chromosome 2-like 1 protein (Chromosome- associated protein E) (XCAP-E homolog) (FGF-inducible protein 16).

MYH14_MOUSE
NC score	0.014689 (rank : 35)	θ value	4.03905 (rank : 37)
Query Neighborhood Hits	74	Target Neighborhood Hits	1225	Shared Neighborhood Hits	34
SwissProt Accessions	Q6URW6, Q80V64, Q80ZE6	Gene names	Myh14
Domain Architecture	No domain graphic available
Description	Myosin-14 (Myosin heavy chain, nonmuscle IIc) (Nonmuscle myosin heavy chain IIc) (NMHC II-C).

TBCD1_MOUSE
NC score	0.013574 (rank : 36)	θ value	1.81305 (rank : 24)
Query Neighborhood Hits	74	Target Neighborhood Hits	241	Shared Neighborhood Hits	13
SwissProt Accessions	Q60949, Q80TJ9, Q923F8	Gene names	Tbc1d1, Kiaa1108, Tbc1
Domain Architecture
Description	TBC1 domain family member 1.

PI3R6_HUMAN
NC score	0.013506 (rank : 37)	θ value	6.88961 (rank : 58)
Query Neighborhood Hits	74	Target Neighborhood Hits	16	Shared Neighborhood Hits	3
SwissProt Accessions	Q5UE93, Q658R3	Gene names	PIK3R6, C17orf38
Domain Architecture	No domain graphic available
Description	Phosphoinositide 3-kinase regulatory subunit 6 (Phosphoinositide 3- kinase gamma adapter protein of 87 kDa) (p87 PI3K adapter protein) (p87PIKAP).

S26A6_HUMAN
NC score	0.012687 (rank : 38)	θ value	3.0926 (rank : 33)
Query Neighborhood Hits	74	Target Neighborhood Hits	32	Shared Neighborhood Hits	3
SwissProt Accessions	Q9BXS9, Q96Q90	Gene names	SLC26A6
Domain Architecture
Description	Solute carrier family 26 member 6 (Pendrin-like protein 1) (Pendrin L1).

SC11A_MOUSE
NC score	0.012083 (rank : 39)	θ value	5.27518 (rank : 47)
Query Neighborhood Hits	74	Target Neighborhood Hits	116	Shared Neighborhood Hits	7
SwissProt Accessions	Q9R053, Q9JMD4	Gene names	Scn11a, Nan, Nat, Sns2
Domain Architecture	No domain graphic available
Description	Sodium channel protein type 11 subunit alpha (Sodium channel protein type XI subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.9) (Sensory neuron sodium channel 2) (NaN).

CEP63_HUMAN
NC score	0.011744 (rank : 40)	θ value	6.88961 (rank : 52)
Query Neighborhood Hits	74	Target Neighborhood Hits	1005	Shared Neighborhood Hits	30
SwissProt Accessions	Q96MT8, Q96CR0, Q9H8F5, Q9H8N0	Gene names	CEP63
Domain Architecture	No domain graphic available
Description	Centrosomal protein of 63 kDa (Cep63 protein).

CCD41_MOUSE
NC score	0.011696 (rank : 41)	θ value	5.27518 (rank : 43)
Query Neighborhood Hits	74	Target Neighborhood Hits	1399	Shared Neighborhood Hits	31
SwissProt Accessions	Q9D5R3, Q3U7X7, Q3UX57, Q80VF0	Gene names	Ccdc41
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 41.

HMMR_HUMAN
NC score	0.011493 (rank : 42)	θ value	8.99809 (rank : 66)
Query Neighborhood Hits	74	Target Neighborhood Hits	1082	Shared Neighborhood Hits	29
SwissProt Accessions	O75330, Q92767	Gene names	HMMR, IHABP, RHAMM
Domain Architecture
Description	Hyaluronan mediated motility receptor (Intracellular hyaluronic acid- binding protein) (Receptor for hyaluronan-mediated motility) (CD168 antigen).

MYO5A_MOUSE
NC score	0.010865 (rank : 43)	θ value	5.27518 (rank : 46)
Query Neighborhood Hits	74	Target Neighborhood Hits	1117	Shared Neighborhood Hits	30
SwissProt Accessions	Q99104	Gene names	Myo5a, Dilute
Domain Architecture
Description	Myosin-5A (Myosin Va) (Dilute myosin heavy chain, non-muscle).

ADDA_MOUSE
NC score	0.010598 (rank : 44)	θ value	1.81305 (rank : 23)
Query Neighborhood Hits	74	Target Neighborhood Hits	198	Shared Neighborhood Hits	2
SwissProt Accessions	Q9QYC0, Q9JLE3	Gene names	Add1
Domain Architecture
Description	Alpha-adducin (Erythrocyte adducin subunit alpha).

CP2AC_MOUSE
NC score	0.010537 (rank : 45)	θ value	0.813845 (rank : 16)
Query Neighborhood Hits	74	Target Neighborhood Hits	110	Shared Neighborhood Hits	4
SwissProt Accessions	P56593	Gene names	Cyp2a12
Domain Architecture	No domain graphic available
Description	Cytochrome P450 2A12 (EC 1.14.14.1) (CYPIIA12) (Steroid hormones 7- alpha-hydroxylase) (Testosterone 7-alpha-hydroxylase).

DYH11_HUMAN
NC score	0.010077 (rank : 46)	θ value	5.27518 (rank : 44)
Query Neighborhood Hits	74	Target Neighborhood Hits	234	Shared Neighborhood Hits	13
SwissProt Accessions	Q96DT5, Q9UJ82	Gene names	DNAH11
Domain Architecture
Description	Ciliary dynein heavy chain 11 (Axonemal beta dynein heavy chain 11).

CASL_HUMAN
NC score	0.010045 (rank : 47)	θ value	5.27518 (rank : 42)
Query Neighborhood Hits	74	Target Neighborhood Hits	259	Shared Neighborhood Hits	5
SwissProt Accessions	Q14511	Gene names	NEDD9, CASL
Domain Architecture
Description	Enhancer of filamentation 1 (HEF1) (CRK-associated substrate-related protein) (CAS-L) (CasL) (p105) (Protein NEDD9) (NY-REN-12 antigen).

ELMD1_HUMAN
NC score	0.009709 (rank : 48)	θ value	5.27518 (rank : 45)
Query Neighborhood Hits	74	Target Neighborhood Hits	8	Shared Neighborhood Hits	2
SwissProt Accessions	Q8N336, Q9NPW3	Gene names	ELMOD1
Domain Architecture	No domain graphic available
Description	ELMO domain-containing protein 1.

SYF2_MOUSE
NC score	0.009381 (rank : 49)	θ value	8.99809 (rank : 72)
Query Neighborhood Hits	74	Target Neighborhood Hits	48	Shared Neighborhood Hits	3
SwissProt Accessions	Q9D198	Gene names	Syf2, Cbpin, Gcipip
Domain Architecture	No domain graphic available
Description	Pre-mRNA-splicing factor SYF2 (CCNDBP1-interactor) (p29) (mp29).

HOOK2_HUMAN
NC score	0.009152 (rank : 50)	θ value	6.88961 (rank : 56)
Query Neighborhood Hits	74	Target Neighborhood Hits	714	Shared Neighborhood Hits	23
SwissProt Accessions	Q96ED9, O60562	Gene names	HOOK2
Domain Architecture
Description	Hook homolog 2 (h-hook2) (hHK2).

CHD6_HUMAN
NC score	0.008962 (rank : 51)	θ value	2.36792 (rank : 26)
Query Neighborhood Hits	74	Target Neighborhood Hits	342	Shared Neighborhood Hits	11
SwissProt Accessions	Q8TD26, Q5JYQ0, Q5TGZ9, Q5TH00, Q5TH01, Q8IZR2, Q8WTY0, Q9H4H6, Q9H6D4, Q9NTT7, Q9P2L1	Gene names	CHD6, CHD5, KIAA1335, RIGB
Domain Architecture
Description	Chromodomain-helicase-DNA-binding protein 6 (EC 3.6.1.-) (ATP- dependent helicase CHD6) (CHD-6) (Radiation-induced gene B protein).

ANR18_HUMAN
NC score	0.008621 (rank : 52)	θ value	4.03905 (rank : 34)
Query Neighborhood Hits	74	Target Neighborhood Hits	1106	Shared Neighborhood Hits	26
SwissProt Accessions	Q8IVF6, Q7Z468	Gene names	ANKRD18A, KIAA2015
Domain Architecture
Description	Ankyrin repeat domain-containing protein 18A.

CTRO_HUMAN
NC score	0.008530 (rank : 53)	θ value	3.0926 (rank : 30)
Query Neighborhood Hits	74	Target Neighborhood Hits	2092	Shared Neighborhood Hits	34
SwissProt Accessions	O14578, Q6XUH8, Q86UQ9, Q9UPZ7	Gene names	CIT, KIAA0949, STK21
Domain Architecture	No domain graphic available
Description	Citron Rho-interacting kinase (EC 2.7.11.1) (CRIK) (Rho-interacting, serine/threonine-protein kinase 21).

UBR2_HUMAN
NC score	0.008481 (rank : 54)	θ value	4.03905 (rank : 38)
Query Neighborhood Hits	74	Target Neighborhood Hits	45	Shared Neighborhood Hits	3
SwissProt Accessions	Q8IWV8, O15057, Q4VXK2, Q5TFH6, Q6P2I2, Q6ZUD0	Gene names	UBR2, C6orf133, KIAA0349
Domain Architecture	No domain graphic available
Description	Ubiquitin-protein ligase E3 component N-recognin-2 (EC 6.-.-.-) (Ubiquitin-protein ligase E3-alpha-2) (Ubiquitin-protein ligase E3- alpha-II).

CTRO_MOUSE
NC score	0.007932 (rank : 55)	θ value	3.0926 (rank : 31)
Query Neighborhood Hits	74	Target Neighborhood Hits	2344	Shared Neighborhood Hits	34
SwissProt Accessions	P49025, O88528, O88937, O88938, Q3UM99, Q8CIJ1	Gene names	Cit
Domain Architecture
Description	Citron Rho-interacting kinase (EC 2.7.11.1) (CRIK) (Rho-interacting, serine/threonine-protein kinase 21).

MYO5A_HUMAN
NC score	0.007850 (rank : 56)	θ value	8.99809 (rank : 68)
Query Neighborhood Hits	74	Target Neighborhood Hits	1092	Shared Neighborhood Hits	29
SwissProt Accessions	Q9Y4I1, O60653, Q07902, Q16249, Q9UE30, Q9UE31	Gene names	MYO5A, MYH12
Domain Architecture
Description	Myosin-5A (Myosin Va) (Dilute myosin heavy chain, non-muscle) (Myosin heavy chain 12) (Myoxin).

C8AP2_MOUSE
NC score	0.007479 (rank : 57)	θ value	6.88961 (rank : 51)
Query Neighborhood Hits	74	Target Neighborhood Hits	405	Shared Neighborhood Hits	9
SwissProt Accessions	Q9WUF3, Q9CSW2	Gene names	Casp8ap2, Flash
Domain Architecture	No domain graphic available
Description	CASP8-associated protein 2 (FLICE-associated huge protein).

CP2A6_HUMAN
NC score	0.007355 (rank : 58)	θ value	3.0926 (rank : 29)
Query Neighborhood Hits	74	Target Neighborhood Hits	108	Shared Neighborhood Hits	4
SwissProt Accessions	P11509, P00190, P10890, Q16803, Q4VAT9, Q4VAU0, Q4VAU1, Q9H1Z7, Q9UK48	Gene names	CYP2A6
Domain Architecture
Description	Cytochrome P450 2A6 (EC 1.14.14.1) (CYPIIA6) (Coumarin 7-hydroxylase) (P450 IIA3) (CYP2A3) (P450(I)).

LRRC1_MOUSE
NC score	0.007316 (rank : 59)	θ value	3.0926 (rank : 32)
Query Neighborhood Hits	74	Target Neighborhood Hits	281	Shared Neighborhood Hits	6
SwissProt Accessions	Q80VQ1, Q3UI50, Q8BKR1, Q8BUS9	Gene names	Lrrc1
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 1.

ANGP1_HUMAN
NC score	0.007243 (rank : 60)	θ value	5.27518 (rank : 39)
Query Neighborhood Hits	74	Target Neighborhood Hits	254	Shared Neighborhood Hits	16
SwissProt Accessions	Q15389	Gene names	ANGPT1, KIAA0003
Domain Architecture
Description	Angiopoietin-1 precursor (ANG-1).

ANGP1_MOUSE
NC score	0.006842 (rank : 61)	θ value	5.27518 (rank : 40)
Query Neighborhood Hits	74	Target Neighborhood Hits	252	Shared Neighborhood Hits	13
SwissProt Accessions	O08538	Gene names	Angpt1, Agpt
Domain Architecture
Description	Angiopoietin-1 precursor (ANG-1).

TERF2_HUMAN
NC score	0.006827 (rank : 62)	θ value	8.99809 (rank : 73)
Query Neighborhood Hits	74	Target Neighborhood Hits	102	Shared Neighborhood Hits	2
SwissProt Accessions	Q15554	Gene names	TERF2, TRF2
Domain Architecture
Description	Telomeric repeat-binding factor 2 (TTAGGG repeat-binding factor 2) (Telomeric DNA-binding protein).

EMIL1_HUMAN
NC score	0.006725 (rank : 63)	θ value	8.99809 (rank : 64)
Query Neighborhood Hits	74	Target Neighborhood Hits	239	Shared Neighborhood Hits	8
SwissProt Accessions	Q9Y6C2, Q96G58, Q9UG76	Gene names	EMILIN1, EMI
Domain Architecture
Description	EMILIN-1 precursor (Elastin microfibril interface-located protein 1) (Elastin microfibril interfacer 1).

WDTC1_HUMAN
NC score	0.005910 (rank : 64)	θ value	6.88961 (rank : 62)
Query Neighborhood Hits	74	Target Neighborhood Hits	299	Shared Neighborhood Hits	3
SwissProt Accessions	Q8N5D0, Q9NV87, Q9UPW4	Gene names	WDTC1, KIAA1037
Domain Architecture
Description	WD and tetratricopeptide repeats protein 1.

SMG1_MOUSE
NC score	0.005899 (rank : 65)	θ value	8.99809 (rank : 71)
Query Neighborhood Hits	74	Target Neighborhood Hits	212	Shared Neighborhood Hits	6
SwissProt Accessions	Q8BKX6, Q5DU42, Q6ZQC0, Q8BLU4, Q8BWJ5, Q8BXD3	Gene names	Smg1, Kiaa0421
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase SMG1 (EC 2.7.11.1) (SMG-1).

WDTC1_MOUSE
NC score	0.005290 (rank : 66)	θ value	8.99809 (rank : 74)
Query Neighborhood Hits	74	Target Neighborhood Hits	298	Shared Neighborhood Hits	3
SwissProt Accessions	Q80ZK9	Gene names	Wdtc1
Domain Architecture
Description	WD and tetratricopeptide repeats protein 1.

LRRC1_HUMAN
NC score	0.005235 (rank : 67)	θ value	6.88961 (rank : 57)
Query Neighborhood Hits	74	Target Neighborhood Hits	282	Shared Neighborhood Hits	6
SwissProt Accessions	Q9BTT6, Q9HAC0, Q9NVF1	Gene names	LRRC1, LANO
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 1 (LAP and no PDZ protein) (LANO adapter protein).

P2RY1_MOUSE
NC score	0.005235 (rank : 68)	θ value	1.06291 (rank : 20)
Query Neighborhood Hits	74	Target Neighborhood Hits	591	Shared Neighborhood Hits	4
SwissProt Accessions	P49650	Gene names	P2ry1
Domain Architecture
Description	P2Y purinoceptor 1 (ATP receptor) (P2Y1) (Purinergic receptor).

TRPA1_MOUSE
NC score	0.004320 (rank : 69)	θ value	6.88961 (rank : 61)
Query Neighborhood Hits	74	Target Neighborhood Hits	343	Shared Neighborhood Hits	5
SwissProt Accessions	Q8BLA8	Gene names	Trpa1, Anktm1
Domain Architecture	No domain graphic available
Description	Transient receptor potential cation channel subfamily A member 1 (Ankyrin-like with transmembrane domains protein 1).

P2RY1_HUMAN
NC score	0.002503 (rank : 70)	θ value	2.36792 (rank : 27)
Query Neighborhood Hits	74	Target Neighborhood Hits	642	Shared Neighborhood Hits	4
SwissProt Accessions	P47900	Gene names	P2RY1
Domain Architecture
Description	P2Y purinoceptor 1 (ATP receptor) (P2Y1) (Purinergic receptor).

SLIT2_MOUSE
NC score	0.000140 (rank : 71)	θ value	6.88961 (rank : 59)
Query Neighborhood Hits	74	Target Neighborhood Hits	684	Shared Neighborhood Hits	5
SwissProt Accessions	Q9R1B9, Q9Z166	Gene names	Slit2
Domain Architecture
Description	Slit homolog 2 protein precursor (Slit-2) [Contains: Slit homolog 2 protein N-product; Slit homolog 2 protein C-product].

GAK_MOUSE
NC score	0.000118 (rank : 72)	θ value	8.99809 (rank : 65)
Query Neighborhood Hits	74	Target Neighborhood Hits	964	Shared Neighborhood Hits	5
SwissProt Accessions	Q99KY4, Q6P1I8, Q6P9S5, Q8BM74, Q8K0Q4	Gene names	Gak
Domain Architecture	No domain graphic available
Description	Cyclin G-associated kinase (EC 2.7.11.1).

OL139_MOUSE
NC score	-0.000524 (rank : 73)	θ value	8.99809 (rank : 70)
Query Neighborhood Hits	74	Target Neighborhood Hits	736	Shared Neighborhood Hits	5
SwissProt Accessions	Q60891, Q8VGR1, Q9EPY8	Gene names	Olfr139, Mor255-2, Olfr1
Domain Architecture	No domain graphic available
Description	Olfactory receptor 139 (Olfactory receptor 1) (Olfactory receptor 255- 2) (Odorant receptor M5).

O10W1_HUMAN
NC score	-0.001739 (rank : 74)	θ value	8.99809 (rank : 69)
Query Neighborhood Hits	74	Target Neighborhood Hits	711	Shared Neighborhood Hits	3
SwissProt Accessions	Q8NGF6, Q6UXQ2	Gene names	OR10W1
Domain Architecture	No domain graphic available
Description	Olfactory receptor 10W1 (Olfactory receptor OR11-236).