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Network neighborhood for query Sequence : PI3R6_HUMAN

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PI3R6_HUMAN
SwissProt Accessions	Q5UE93, Q658R3	Gene names	PIK3R6, C17orf38
Domain Architecture	No domain graphic available
Description	Phosphoinositide 3-kinase regulatory subunit 6 (Phosphoinositide 3- kinase gamma adapter protein of 87 kDa) (p87 PI3K adapter protein) (p87PIKAP).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

PI3R6_HUMAN
θ value	0 (rank : 1)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	16	Target Neighborhood Hits	16	Shared Neighborhood Hits	16
SwissProt Accessions	Q5UE93, Q658R3	Gene names	PIK3R6, C17orf38
Domain Architecture	No domain graphic available
Description	Phosphoinositide 3-kinase regulatory subunit 6 (Phosphoinositide 3- kinase gamma adapter protein of 87 kDa) (p87 PI3K adapter protein) (p87PIKAP).

PI3R6_MOUSE
θ value	0 (rank : 2)	NC score	0.996163 (rank : 2)
Query Neighborhood Hits	16	Target Neighborhood Hits	15	Shared Neighborhood Hits	5
SwissProt Accessions	Q3U6Q4, Q3TBT5, Q3UAY4, Q8K323	Gene names	Pik3r6
Domain Architecture	No domain graphic available
Description	Phosphoinositide 3-kinase regulatory subunit 6 (Phosphoinositide 3- kinase gamma adapter protein of 87 kDa) (p87 PI3K adapter protein) (p87PIKAP).

PI3R5_MOUSE
θ value	1.33217e-27 (rank : 3)	NC score	0.652667 (rank : 3)
Query Neighborhood Hits	16	Target Neighborhood Hits	21	Shared Neighborhood Hits	4
SwissProt Accessions	Q5SW28, Q3TU01, Q3UDZ2, Q8C215, Q8CGQ7	Gene names	Pik3r5
Domain Architecture	No domain graphic available
Description	Phosphoinositide 3-kinase regulatory subunit 5 (PI3-kinase regulatory subunit 5) (PI3-kinase p101 subunit) (PtdIns-3-kinase p101) (p101- PI3K) (Phosphatidylinositol-4,5-bisphosphate 3-kinase regulatory subunit) (PtdIns-3-kinase regulatory subunit).

PI3R5_HUMAN
θ value	8.63488e-27 (rank : 4)	NC score	0.642492 (rank : 4)
Query Neighborhood Hits	16	Target Neighborhood Hits	24	Shared Neighborhood Hits	4
SwissProt Accessions	Q8WYR1, Q5G936, Q5G938, Q5G939, Q8IZ23, Q9Y2Y2	Gene names	PIK3R5
Domain Architecture	No domain graphic available
Description	Phosphoinositide 3-kinase regulatory subunit 5 (PI3-kinase regulatory subunit 5) (PI3-kinase p101 subunit) (PtdIns-3-kinase p101) (p101- PI3K) (Phosphatidylinositol-4,5-bisphosphate 3-kinase regulatory subunit) (PtdIns-3-kinase regulatory subunit) (Protein FOAP-2).

FMNL_MOUSE
θ value	0.47712 (rank : 5)	NC score	0.032122 (rank : 6)
Query Neighborhood Hits	16	Target Neighborhood Hits	428	Shared Neighborhood Hits	7
SwissProt Accessions	Q9JL26, Q6KAN4, Q9Z2V7	Gene names	Fmnl1, Frl
Domain Architecture	No domain graphic available
Description	Formin-like protein 1 (Formin-related protein).

FHOD1_MOUSE
θ value	1.06291 (rank : 6)	NC score	0.053320 (rank : 5)
Query Neighborhood Hits	16	Target Neighborhood Hits	217	Shared Neighborhood Hits	5
SwissProt Accessions	Q6P9Q4, Q8BMK2	Gene names	Fhod1, Fhos1
Domain Architecture	No domain graphic available
Description	FH1/FH2 domain-containing protein (Formin homolog overexpressed in spleen) (FHOS) (Formin homology 2 domain-containing protein 1).

CO4A5_HUMAN
θ value	1.81305 (rank : 7)	NC score	0.011755 (rank : 10)
Query Neighborhood Hits	16	Target Neighborhood Hits	383	Shared Neighborhood Hits	3
SwissProt Accessions	P29400, Q16006, Q16126, Q6LD84	Gene names	COL4A5
Domain Architecture
Description	Collagen alpha-5(IV) chain precursor.

CASP_HUMAN
θ value	2.36792 (rank : 8)	NC score	0.010999 (rank : 12)
Query Neighborhood Hits	16	Target Neighborhood Hits	1131	Shared Neighborhood Hits	6
SwissProt Accessions	Q13948, Q53GU9, Q8TBS3	Gene names	CUTL1
Domain Architecture	No domain graphic available
Description	Protein CASP.

ELOA3_HUMAN
θ value	2.36792 (rank : 9)	NC score	0.027099 (rank : 7)
Query Neighborhood Hits	16	Target Neighborhood Hits	98	Shared Neighborhood Hits	3
SwissProt Accessions	Q8NG57	Gene names	TCEB3C, TCEB3L2
Domain Architecture
Description	RNA polymerase II transcription factor SIII subunit A3 (Elongin-A3) (EloA3) (Transcription elongation factor B polypeptide 3C).

PLEC1_HUMAN
θ value	4.03905 (rank : 10)	NC score	0.005573 (rank : 16)
Query Neighborhood Hits	16	Target Neighborhood Hits	1326	Shared Neighborhood Hits	5
SwissProt Accessions	Q15149, Q15148, Q16640	Gene names	PLEC1
Domain Architecture
Description	Plectin-1 (PLTN) (PCN) (Hemidesmosomal protein 1) (HD1).

JPH2_HUMAN
θ value	5.27518 (rank : 11)	NC score	0.011667 (rank : 11)
Query Neighborhood Hits	16	Target Neighborhood Hits	639	Shared Neighborhood Hits	6
SwissProt Accessions	Q9BR39, O95913, Q5JY74, Q9UJN4	Gene names	JPH2, JP2
Domain Architecture
Description	Junctophilin-2 (Junctophilin type 2) (JP-2).

CUTL1_HUMAN
θ value	6.88961 (rank : 12)	NC score	0.008548 (rank : 15)
Query Neighborhood Hits	16	Target Neighborhood Hits	1574	Shared Neighborhood Hits	7
SwissProt Accessions	P39880, Q6NYH4, Q9UEV5	Gene names	CUTL1
Domain Architecture	No domain graphic available
Description	Homeobox protein cut-like 1 (CCAAT displacement protein) (CDP).

ITPR2_HUMAN
θ value	6.88961 (rank : 13)	NC score	0.013506 (rank : 9)
Query Neighborhood Hits	16	Target Neighborhood Hits	74	Shared Neighborhood Hits	3
SwissProt Accessions	Q14571, O94773	Gene names	ITPR2
Domain Architecture
Description	Inositol 1,4,5-trisphosphate receptor type 2 (Type 2 inositol 1,4,5- trisphosphate receptor) (Type 2 InsP3 receptor) (IP3 receptor isoform 2) (InsP3R2).

ITPR2_MOUSE
θ value	6.88961 (rank : 14)	NC score	0.013508 (rank : 8)
Query Neighborhood Hits	16	Target Neighborhood Hits	69	Shared Neighborhood Hits	3
SwissProt Accessions	Q9Z329, P70226, Q5DWM3, Q5DWM5, Q61744, Q8R3B0	Gene names	Itpr2, Itpr5
Domain Architecture	No domain graphic available
Description	Inositol 1,4,5-trisphosphate receptor type 2 (Type 2 inositol 1,4,5- trisphosphate receptor) (Type 2 InsP3 receptor) (IP3 receptor isoform 2) (InsP3R2) (Inositol 1,4,5-trisphosphate type V receptor).

JIP3_HUMAN
θ value	6.88961 (rank : 15)	NC score	0.010336 (rank : 14)
Query Neighborhood Hits	16	Target Neighborhood Hits	1039	Shared Neighborhood Hits	7
SwissProt Accessions	Q9UPT6, Q96RY4, Q9H4I4, Q9H7P1, Q9NUG0	Gene names	MAPK8IP3, JIP3, KIAA1066
Domain Architecture
Description	C-jun-amino-terminal kinase-interacting protein 3 (JNK-interacting protein 3) (JIP-3) (JNK MAP kinase scaffold protein 3) (Mitogen- activated protein kinase 8-interacting protein 3).

SNX1_HUMAN
θ value	6.88961 (rank : 16)	NC score	0.010726 (rank : 13)
Query Neighborhood Hits	16	Target Neighborhood Hits	125	Shared Neighborhood Hits	2
SwissProt Accessions	Q13596, O60750, O60751	Gene names	SNX1
Domain Architecture
Description	Sorting nexin-1.

Hits sorted by NC score

PI3R6_HUMAN
NC score	0.999962 (rank : 1)	θ value	0 (rank : 1)
Query Neighborhood Hits	16	Target Neighborhood Hits	16	Shared Neighborhood Hits	16
SwissProt Accessions	Q5UE93, Q658R3	Gene names	PIK3R6, C17orf38
Domain Architecture	No domain graphic available
Description	Phosphoinositide 3-kinase regulatory subunit 6 (Phosphoinositide 3- kinase gamma adapter protein of 87 kDa) (p87 PI3K adapter protein) (p87PIKAP).

PI3R6_MOUSE
NC score	0.996163 (rank : 2)	θ value	0 (rank : 2)
Query Neighborhood Hits	16	Target Neighborhood Hits	15	Shared Neighborhood Hits	5
SwissProt Accessions	Q3U6Q4, Q3TBT5, Q3UAY4, Q8K323	Gene names	Pik3r6
Domain Architecture	No domain graphic available
Description	Phosphoinositide 3-kinase regulatory subunit 6 (Phosphoinositide 3- kinase gamma adapter protein of 87 kDa) (p87 PI3K adapter protein) (p87PIKAP).

PI3R5_MOUSE
NC score	0.652667 (rank : 3)	θ value	1.33217e-27 (rank : 3)
Query Neighborhood Hits	16	Target Neighborhood Hits	21	Shared Neighborhood Hits	4
SwissProt Accessions	Q5SW28, Q3TU01, Q3UDZ2, Q8C215, Q8CGQ7	Gene names	Pik3r5
Domain Architecture	No domain graphic available
Description	Phosphoinositide 3-kinase regulatory subunit 5 (PI3-kinase regulatory subunit 5) (PI3-kinase p101 subunit) (PtdIns-3-kinase p101) (p101- PI3K) (Phosphatidylinositol-4,5-bisphosphate 3-kinase regulatory subunit) (PtdIns-3-kinase regulatory subunit).

PI3R5_HUMAN
NC score	0.642492 (rank : 4)	θ value	8.63488e-27 (rank : 4)
Query Neighborhood Hits	16	Target Neighborhood Hits	24	Shared Neighborhood Hits	4
SwissProt Accessions	Q8WYR1, Q5G936, Q5G938, Q5G939, Q8IZ23, Q9Y2Y2	Gene names	PIK3R5
Domain Architecture	No domain graphic available
Description	Phosphoinositide 3-kinase regulatory subunit 5 (PI3-kinase regulatory subunit 5) (PI3-kinase p101 subunit) (PtdIns-3-kinase p101) (p101- PI3K) (Phosphatidylinositol-4,5-bisphosphate 3-kinase regulatory subunit) (PtdIns-3-kinase regulatory subunit) (Protein FOAP-2).

FHOD1_MOUSE
NC score	0.053320 (rank : 5)	θ value	1.06291 (rank : 6)
Query Neighborhood Hits	16	Target Neighborhood Hits	217	Shared Neighborhood Hits	5
SwissProt Accessions	Q6P9Q4, Q8BMK2	Gene names	Fhod1, Fhos1
Domain Architecture	No domain graphic available
Description	FH1/FH2 domain-containing protein (Formin homolog overexpressed in spleen) (FHOS) (Formin homology 2 domain-containing protein 1).

FMNL_MOUSE
NC score	0.032122 (rank : 6)	θ value	0.47712 (rank : 5)
Query Neighborhood Hits	16	Target Neighborhood Hits	428	Shared Neighborhood Hits	7
SwissProt Accessions	Q9JL26, Q6KAN4, Q9Z2V7	Gene names	Fmnl1, Frl
Domain Architecture	No domain graphic available
Description	Formin-like protein 1 (Formin-related protein).

ELOA3_HUMAN
NC score	0.027099 (rank : 7)	θ value	2.36792 (rank : 9)
Query Neighborhood Hits	16	Target Neighborhood Hits	98	Shared Neighborhood Hits	3
SwissProt Accessions	Q8NG57	Gene names	TCEB3C, TCEB3L2
Domain Architecture
Description	RNA polymerase II transcription factor SIII subunit A3 (Elongin-A3) (EloA3) (Transcription elongation factor B polypeptide 3C).

ITPR2_MOUSE
NC score	0.013508 (rank : 8)	θ value	6.88961 (rank : 14)
Query Neighborhood Hits	16	Target Neighborhood Hits	69	Shared Neighborhood Hits	3
SwissProt Accessions	Q9Z329, P70226, Q5DWM3, Q5DWM5, Q61744, Q8R3B0	Gene names	Itpr2, Itpr5
Domain Architecture	No domain graphic available
Description	Inositol 1,4,5-trisphosphate receptor type 2 (Type 2 inositol 1,4,5- trisphosphate receptor) (Type 2 InsP3 receptor) (IP3 receptor isoform 2) (InsP3R2) (Inositol 1,4,5-trisphosphate type V receptor).

ITPR2_HUMAN
NC score	0.013506 (rank : 9)	θ value	6.88961 (rank : 13)
Query Neighborhood Hits	16	Target Neighborhood Hits	74	Shared Neighborhood Hits	3
SwissProt Accessions	Q14571, O94773	Gene names	ITPR2
Domain Architecture
Description	Inositol 1,4,5-trisphosphate receptor type 2 (Type 2 inositol 1,4,5- trisphosphate receptor) (Type 2 InsP3 receptor) (IP3 receptor isoform 2) (InsP3R2).

CO4A5_HUMAN
NC score	0.011755 (rank : 10)	θ value	1.81305 (rank : 7)
Query Neighborhood Hits	16	Target Neighborhood Hits	383	Shared Neighborhood Hits	3
SwissProt Accessions	P29400, Q16006, Q16126, Q6LD84	Gene names	COL4A5
Domain Architecture
Description	Collagen alpha-5(IV) chain precursor.

JPH2_HUMAN
NC score	0.011667 (rank : 11)	θ value	5.27518 (rank : 11)
Query Neighborhood Hits	16	Target Neighborhood Hits	639	Shared Neighborhood Hits	6
SwissProt Accessions	Q9BR39, O95913, Q5JY74, Q9UJN4	Gene names	JPH2, JP2
Domain Architecture
Description	Junctophilin-2 (Junctophilin type 2) (JP-2).

CASP_HUMAN
NC score	0.010999 (rank : 12)	θ value	2.36792 (rank : 8)
Query Neighborhood Hits	16	Target Neighborhood Hits	1131	Shared Neighborhood Hits	6
SwissProt Accessions	Q13948, Q53GU9, Q8TBS3	Gene names	CUTL1
Domain Architecture	No domain graphic available
Description	Protein CASP.

SNX1_HUMAN
NC score	0.010726 (rank : 13)	θ value	6.88961 (rank : 16)
Query Neighborhood Hits	16	Target Neighborhood Hits	125	Shared Neighborhood Hits	2
SwissProt Accessions	Q13596, O60750, O60751	Gene names	SNX1
Domain Architecture
Description	Sorting nexin-1.

JIP3_HUMAN
NC score	0.010336 (rank : 14)	θ value	6.88961 (rank : 15)
Query Neighborhood Hits	16	Target Neighborhood Hits	1039	Shared Neighborhood Hits	7
SwissProt Accessions	Q9UPT6, Q96RY4, Q9H4I4, Q9H7P1, Q9NUG0	Gene names	MAPK8IP3, JIP3, KIAA1066
Domain Architecture
Description	C-jun-amino-terminal kinase-interacting protein 3 (JNK-interacting protein 3) (JIP-3) (JNK MAP kinase scaffold protein 3) (Mitogen- activated protein kinase 8-interacting protein 3).

CUTL1_HUMAN
NC score	0.008548 (rank : 15)	θ value	6.88961 (rank : 12)
Query Neighborhood Hits	16	Target Neighborhood Hits	1574	Shared Neighborhood Hits	7
SwissProt Accessions	P39880, Q6NYH4, Q9UEV5	Gene names	CUTL1
Domain Architecture	No domain graphic available
Description	Homeobox protein cut-like 1 (CCAAT displacement protein) (CDP).

PLEC1_HUMAN
NC score	0.005573 (rank : 16)	θ value	4.03905 (rank : 10)
Query Neighborhood Hits	16	Target Neighborhood Hits	1326	Shared Neighborhood Hits	5
SwissProt Accessions	Q15149, Q15148, Q16640	Gene names	PLEC1
Domain Architecture
Description	Plectin-1 (PLTN) (PCN) (Hemidesmosomal protein 1) (HD1).