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Network neighborhood for query Sequence : KCNH2_MOUSE

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KCNH2_MOUSE
SwissProt Accessions	O35219, O35220, O35221, O35989	Gene names	Kcnh2, Erg, Merg1
Domain Architecture
Description	Potassium voltage-gated channel subfamily H member 2 (Voltage-gated potassium channel subunit Kv11.1) (Ether-a-go-go-related gene potassium channel 1) (ERG1) (MERG) (Merg1) (Ether-a-go-go-related protein 1) (Eag-related protein 1).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

KCNH2_HUMAN
θ value	0 (rank : 1)	NC score	0.995949 (rank : 2)
Query Neighborhood Hits	165	Target Neighborhood Hits	158	Shared Neighborhood Hits	110
SwissProt Accessions	Q12809, O75418, O75680, Q9BT72, Q9BUT7, Q9H3P0	Gene names	KCNH2, ERG, ERG1, HERG, HERG1
Domain Architecture
Description	Potassium voltage-gated channel subfamily H member 2 (Voltage-gated potassium channel subunit Kv11.1) (Ether-a-go-go-related gene potassium channel 1) (H-ERG) (Erg1) (Ether-a-go-go-related protein 1) (Eag-related protein 1) (eag homolog).

KCNH2_MOUSE
θ value	0 (rank : 2)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	165	Target Neighborhood Hits	165	Shared Neighborhood Hits	165
SwissProt Accessions	O35219, O35220, O35221, O35989	Gene names	Kcnh2, Erg, Merg1
Domain Architecture
Description	Potassium voltage-gated channel subfamily H member 2 (Voltage-gated potassium channel subunit Kv11.1) (Ether-a-go-go-related gene potassium channel 1) (ERG1) (MERG) (Merg1) (Ether-a-go-go-related protein 1) (Eag-related protein 1).

KCNH6_HUMAN
θ value	0 (rank : 3)	NC score	0.979441 (rank : 5)
Query Neighborhood Hits	165	Target Neighborhood Hits	222	Shared Neighborhood Hits	77
SwissProt Accessions	Q9H252, Q9BRD7	Gene names	KCNH6, ERG2, HERG2
Domain Architecture
Description	Potassium voltage-gated channel subfamily H member 6 (Voltage-gated potassium channel subunit Kv11.2) (Ether-a-go-go-related gene potassium channel 2) (Ether-a-go-go-related protein 2) (Eag-related protein 2).

KCNH7_HUMAN
θ value	0 (rank : 4)	NC score	0.989176 (rank : 4)
Query Neighborhood Hits	165	Target Neighborhood Hits	107	Shared Neighborhood Hits	72
SwissProt Accessions	Q9NS40	Gene names	KCNH7, ERG3
Domain Architecture
Description	Potassium voltage-gated channel subfamily H member 7 (Voltage-gated potassium channel subunit Kv11.3) (Ether-a-go-go-related gene potassium channel 3) (HERG-3) (Ether-a-go-go-related protein 3) (Eag- related protein 3).

KCNH7_MOUSE
θ value	0 (rank : 5)	NC score	0.989898 (rank : 3)
Query Neighborhood Hits	165	Target Neighborhood Hits	98	Shared Neighborhood Hits	72
SwissProt Accessions	Q9ER47	Gene names	Kcnh7, Erg3
Domain Architecture
Description	Potassium voltage-gated channel subfamily H member 7 (Voltage-gated potassium channel subunit Kv11.3) (Ether-a-go-go-related gene potassium channel 3) (Ether-a-go-go-related protein 3) (Eag-related protein 3).

KCNH8_HUMAN
θ value	6.21357e-126 (rank : 6)	NC score	0.960275 (rank : 6)
Query Neighborhood Hits	165	Target Neighborhood Hits	104	Shared Neighborhood Hits	58
SwissProt Accessions	Q96L42	Gene names	KCNH8
Domain Architecture
Description	Potassium voltage-gated channel subfamily H member 8 (Voltage-gated potassium channel subunit Kv12.1) (Ether-a-go-go-like potassium channel 3) (ELK channel 3) (ELK3) (ELK1) (hElk1).

KCNH5_HUMAN
θ value	3.19119e-122 (rank : 7)	NC score	0.954007 (rank : 9)
Query Neighborhood Hits	165	Target Neighborhood Hits	99	Shared Neighborhood Hits	57
SwissProt Accessions	Q8NCM2	Gene names	KCNH5, EAG2
Domain Architecture
Description	Potassium voltage-gated channel subfamily H member 5 (Voltage-gated potassium channel subunit Kv10.2) (Ether-a-go-go potassium channel 2) (hEAG2).

KCNH5_MOUSE
θ value	7.10925e-122 (rank : 8)	NC score	0.954017 (rank : 8)
Query Neighborhood Hits	165	Target Neighborhood Hits	102	Shared Neighborhood Hits	57
SwissProt Accessions	Q920E3, Q8C035	Gene names	Kcnh5, Eag2
Domain Architecture	No domain graphic available
Description	Potassium voltage-gated channel subfamily H member 5 (Voltage-gated potassium channel subunit Kv10.2) (Ether-a-go-go potassium channel 2) (Eag2).

KCNH1_HUMAN
θ value	3.52827e-121 (rank : 9)	NC score	0.953264 (rank : 11)
Query Neighborhood Hits	165	Target Neighborhood Hits	98	Shared Neighborhood Hits	58
SwissProt Accessions	O95259, O76035	Gene names	KCNH1, EAG, EAG1
Domain Architecture
Description	Potassium voltage-gated channel subfamily H member 1 (Voltage-gated potassium channel subunit Kv10.1) (Ether-a-go-go potassium channel 1) (hEAG1) (h-eag).

KCNH1_MOUSE
θ value	4.60808e-121 (rank : 10)	NC score	0.953382 (rank : 10)
Query Neighborhood Hits	165	Target Neighborhood Hits	94	Shared Neighborhood Hits	58
SwissProt Accessions	Q60603	Gene names	Kcnh1, Eag
Domain Architecture
Description	Potassium voltage-gated channel subfamily H member 1 (Voltage-gated potassium channel subunit Kv10.1) (Ether-a-go-go potassium channel 1) (EAG1) (m-eag).

KCNH4_HUMAN
θ value	4.60808e-121 (rank : 11)	NC score	0.957133 (rank : 7)
Query Neighborhood Hits	165	Target Neighborhood Hits	177	Shared Neighborhood Hits	60
SwissProt Accessions	Q9UQ05	Gene names	KCNH4
Domain Architecture
Description	Potassium voltage-gated channel subfamily H member 4 (Voltage-gated potassium channel subunit Kv12.3) (Ether-a-go-go-like potassium channel 1) (ELK channel 1) (ELK1) (Brain-specific eag-like channel 2) (BEC2).

KCNH3_HUMAN
θ value	1.02895e-112 (rank : 12)	NC score	0.951699 (rank : 12)
Query Neighborhood Hits	165	Target Neighborhood Hits	148	Shared Neighborhood Hits	62
SwissProt Accessions	Q9ULD8, Q9UQ06	Gene names	KCNH3, KIAA1282
Domain Architecture
Description	Potassium voltage-gated channel subfamily H member 3 (Voltage-gated potassium channel subunit Kv12.2) (Ether-a-go-go-like potassium channel 2) (ELK channel 2) (ELK2) (Brain-specific eag-like channel 1) (BEC1).

KCNH3_MOUSE
θ value	1.75513e-112 (rank : 13)	NC score	0.951348 (rank : 13)
Query Neighborhood Hits	165	Target Neighborhood Hits	133	Shared Neighborhood Hits	60
SwissProt Accessions	Q9WVJ0	Gene names	Kcnh3, Elk2
Domain Architecture
Description	Potassium voltage-gated channel subfamily H member 3 (Voltage-gated potassium channel subunit Kv12.2) (Ether-a-go-go-like potassium channel 2) (ELK channel 2) (mElk2).

HCN4_HUMAN
θ value	1.51715e-39 (rank : 14)	NC score	0.792674 (rank : 24)
Query Neighborhood Hits	165	Target Neighborhood Hits	303	Shared Neighborhood Hits	58
SwissProt Accessions	Q9Y3Q4, Q9UMQ7	Gene names	HCN4
Domain Architecture
Description	Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4.

HCN2_HUMAN
θ value	5.76516e-39 (rank : 15)	NC score	0.787630 (rank : 26)
Query Neighborhood Hits	165	Target Neighborhood Hits	369	Shared Neighborhood Hits	63
SwissProt Accessions	Q9UL51, O60742, O60743, O75267, Q9UBS2	Gene names	HCN2, BCNG2
Domain Architecture
Description	Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 (Brain cyclic nucleotide-gated channel 2) (BCNG-2).

HCN2_MOUSE
θ value	5.76516e-39 (rank : 16)	NC score	0.795086 (rank : 23)
Query Neighborhood Hits	165	Target Neighborhood Hits	278	Shared Neighborhood Hits	62
SwissProt Accessions	O88703, O70506	Gene names	Hcn2, Bcng2, Hac1
Domain Architecture
Description	Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 (Brain cyclic nucleotide-gated channel 2) (BCNG-2) (Hyperpolarization-activated cation channel 1) (HAC-1).

HCN3_HUMAN
θ value	1.28434e-38 (rank : 17)	NC score	0.804992 (rank : 21)
Query Neighborhood Hits	165	Target Neighborhood Hits	99	Shared Neighborhood Hits	38
SwissProt Accessions	Q9P1Z3, Q4VX12, Q8N6W6, Q9BWQ2	Gene names	HCN3, KIAA1535
Domain Architecture
Description	Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 3.

HCN4_MOUSE
θ value	1.6774e-38 (rank : 18)	NC score	0.790278 (rank : 25)
Query Neighborhood Hits	165	Target Neighborhood Hits	284	Shared Neighborhood Hits	60
SwissProt Accessions	O70507	Gene names	Hcn4, Bcng3
Domain Architecture
Description	Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 (Brain cyclic nucleotide-gated channel 3) (BCNG-3).

HCN1_HUMAN
θ value	2.19075e-38 (rank : 19)	NC score	0.808160 (rank : 18)
Query Neighborhood Hits	165	Target Neighborhood Hits	120	Shared Neighborhood Hits	41
SwissProt Accessions	O60741	Gene names	HCN1, BCNG1
Domain Architecture
Description	Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1 (Brain cyclic nucleotide-gated channel 1) (BCNG-1).

HCN1_MOUSE
θ value	2.19075e-38 (rank : 20)	NC score	0.804661 (rank : 22)
Query Neighborhood Hits	165	Target Neighborhood Hits	172	Shared Neighborhood Hits	44
SwissProt Accessions	O88704, O54899, Q9D613	Gene names	Hcn1, Bcng1, Hac2
Domain Architecture
Description	Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1 (Brain cyclic nucleotide-gated channel 1) (BCNG-1) (Hyperpolarization-activated cation channel 2) (HAC-2).

HCN3_MOUSE
θ value	4.88048e-38 (rank : 21)	NC score	0.805018 (rank : 20)
Query Neighborhood Hits	165	Target Neighborhood Hits	112	Shared Neighborhood Hits	38
SwissProt Accessions	O88705	Gene names	Hcn3, Hac3
Domain Architecture
Description	Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 3 (Hyperpolarization-activated cation channel 3) (HAC-3).

CNGA3_HUMAN
θ value	2.67802e-36 (rank : 22)	NC score	0.808631 (rank : 17)
Query Neighborhood Hits	165	Target Neighborhood Hits	125	Shared Neighborhood Hits	39
SwissProt Accessions	Q16281, Q9UP64	Gene names	CNGA3, CNCG3
Domain Architecture
Description	Cyclic nucleotide-gated cation channel alpha 3 (CNG channel alpha 3) (CNG-3) (CNG3) (Cyclic nucleotide-gated channel alpha 3) (Cone photoreceptor cGMP-gated channel subunit alpha).

CNGA2_MOUSE
θ value	3.86705e-35 (rank : 23)	NC score	0.822740 (rank : 14)
Query Neighborhood Hits	165	Target Neighborhood Hits	86	Shared Neighborhood Hits	42
SwissProt Accessions	Q62398	Gene names	Cnga2, Cncg2, Cncg4
Domain Architecture
Description	Cyclic nucleotide-gated olfactory channel (Cyclic nucleotide-gated cation channel 2) (CNG channel 2) (CNG-2) (CNG2).

CNGA3_MOUSE
θ value	1.12514e-34 (rank : 24)	NC score	0.811639 (rank : 16)
Query Neighborhood Hits	165	Target Neighborhood Hits	84	Shared Neighborhood Hits	41
SwissProt Accessions	Q9JJZ8, Q9WV01	Gene names	Cnga3, Cng3
Domain Architecture
Description	Cyclic nucleotide-gated cation channel alpha 3 (CNG channel alpha 3) (CNG-3) (CNG3) (Cyclic nucleotide-gated channel alpha 3) (Cone photoreceptor cGMP-gated channel subunit alpha).

CNGA1_HUMAN
θ value	5.584e-34 (rank : 25)	NC score	0.811951 (rank : 15)
Query Neighborhood Hits	165	Target Neighborhood Hits	149	Shared Neighborhood Hits	38
SwissProt Accessions	P29973, Q16279, Q16485	Gene names	CNGA1, CNCG, CNCG1
Domain Architecture
Description	cGMP-gated cation channel alpha 1 (CNG channel alpha 1) (CNG-1) (CNG1) (Cyclic nucleotide-gated channel alpha 1) (Cyclic nucleotide-gated channel, photoreceptor) (Cyclic nucleotide-gated cation channel 1) (Rod photoreceptor cGMP-gated channel subunit alpha).

CNGA1_MOUSE
θ value	2.12192e-33 (rank : 26)	NC score	0.806974 (rank : 19)
Query Neighborhood Hits	165	Target Neighborhood Hits	198	Shared Neighborhood Hits	40
SwissProt Accessions	P29974, Q60776	Gene names	Cnga1, Cncg, Cncg1
Domain Architecture
Description	cGMP-gated cation channel alpha 1 (CNG channel alpha 1) (CNG-1) (CNG1) (Cyclic nucleotide-gated channel alpha 1) (Cyclic nucleotide-gated channel, photoreceptor) (Cyclic nucleotide-gated cation channel 1) (Rod photoreceptor cGMP-gated channel subunit alpha).

CNGB3_MOUSE
θ value	9.87957e-23 (rank : 27)	NC score	0.754511 (rank : 27)
Query Neighborhood Hits	165	Target Neighborhood Hits	74	Shared Neighborhood Hits	39
SwissProt Accessions	Q9JJZ9	Gene names	Cngb3, Cng6
Domain Architecture
Description	Cyclic nucleotide-gated cation channel beta 3 (CNG channel beta 3) (Cyclic nucleotide-gated channel beta 3) (Cone photoreceptor cGMP- gated channel subunit beta) (Cyclic nucleotide-gated cation channel modulatory subunit) (Cyclic nucleotide-gated channel subunit CNG6).

CNGB3_HUMAN
θ value	1.74391e-19 (rank : 28)	NC score	0.739150 (rank : 28)
Query Neighborhood Hits	165	Target Neighborhood Hits	206	Shared Neighborhood Hits	43
SwissProt Accessions	Q9NQW8, Q9NRE9	Gene names	CNGB3
Domain Architecture
Description	Cyclic nucleotide-gated cation channel beta 3 (CNG channel beta 3) (Cyclic nucleotide-gated channel beta 3) (Cone photoreceptor cGMP- gated channel subunit beta) (Cyclic nucleotide-gated cation channel modulatory subunit).

CNGB1_HUMAN
θ value	5.60996e-18 (rank : 29)	NC score	0.731567 (rank : 29)
Query Neighborhood Hits	165	Target Neighborhood Hits	222	Shared Neighborhood Hits	41
SwissProt Accessions	Q14028, Q14029	Gene names	CNGB1, CNCG4
Domain Architecture
Description	Cyclic nucleotide-gated cation channel 4 (CNG channel 4) (CNG-4) (CNG4) (Cyclic nucleotide-gated cation channel modulatory subunit).

KCNKH_HUMAN
θ value	0.00298849 (rank : 30)	NC score	0.246931 (rank : 30)
Query Neighborhood Hits	165	Target Neighborhood Hits	89	Shared Neighborhood Hits	46
SwissProt Accessions	Q96T54, Q5TCF4, Q8TAW4, Q9BXD1, Q9H592	Gene names	KCNK17, TALK2, TASK4
Domain Architecture
Description	Potassium channel subfamily K member 17 (TWIK-related alkaline pH- activated K(+) channel 2) (2P domain potassium channel Talk-2) (TWIK- related acid-sensitive K(+) channel 4) (TASK-4).

KCNK2_HUMAN
θ value	0.0113563 (rank : 31)	NC score	0.183939 (rank : 32)
Query Neighborhood Hits	165	Target Neighborhood Hits	86	Shared Neighborhood Hits	46
SwissProt Accessions	O95069, Q9UNE3	Gene names	KCNK2, TREK, TREK1
Domain Architecture	No domain graphic available
Description	Potassium channel subfamily K member 2 (Outward rectifying potassium channel protein TREK-1) (TREK-1 K(+) channel subunit) (Two-pore potassium channel TPKC1).

KCNK2_MOUSE
θ value	0.0113563 (rank : 32)	NC score	0.183304 (rank : 33)
Query Neighborhood Hits	165	Target Neighborhood Hits	88	Shared Neighborhood Hits	46
SwissProt Accessions	P97438	Gene names	Kcnk2
Domain Architecture	No domain graphic available
Description	Potassium channel subfamily K member 2 (Outward rectifying potassium channel protein TREK-1) (Two-pore potassium channel TPKC1) (TREK-1 K(+) channel subunit).

KCNKF_HUMAN
θ value	0.0113563 (rank : 33)	NC score	0.188300 (rank : 31)
Query Neighborhood Hits	165	Target Neighborhood Hits	87	Shared Neighborhood Hits	44
SwissProt Accessions	Q9H427, Q9HBC8	Gene names	KCNK15, TASK5
Domain Architecture
Description	Potassium channel subfamily K member 15 (Acid-sensitive potassium channel protein TASK-5) (TWIK-related acid-sensitive K(+) channel 5) (Two pore potassium channel KT3.3).

NRG2_MOUSE
θ value	0.0148317 (rank : 34)	NC score	0.033621 (rank : 82)
Query Neighborhood Hits	165	Target Neighborhood Hits	392	Shared Neighborhood Hits	10
SwissProt Accessions	P56974	Gene names	Nrg2
Domain Architecture	No domain graphic available
Description	Pro-neuregulin-2, membrane-bound isoform precursor (Pro-NRG2) [Contains: Neuregulin-2 (NRG-2) (Divergent of neuregulin 1) (DON-1)].

SCN7A_HUMAN
θ value	0.0252991 (rank : 35)	NC score	0.019201 (rank : 105)
Query Neighborhood Hits	165	Target Neighborhood Hits	135	Shared Neighborhood Hits	11
SwissProt Accessions	Q01118	Gene names	SCN7A, SCN6A
Domain Architecture
Description	Sodium channel protein type 7 subunit alpha (Sodium channel protein type VII subunit alpha) (Putative voltage-gated sodium channel alpha subunit Nax) (Sodium channel protein, cardiac and skeletal muscle alpha-subunit).

OGFR_HUMAN
θ value	0.0431538 (rank : 36)	NC score	0.040021 (rank : 77)
Query Neighborhood Hits	165	Target Neighborhood Hits	1582	Shared Neighborhood Hits	57
SwissProt Accessions	Q9NZT2, O96029, Q4VXW5, Q96CM2, Q9BQW1, Q9H4H0, Q9H7J5, Q9NZT3, Q9NZT4	Gene names	OGFR
Domain Architecture
Description	Opioid growth factor receptor (OGFr) (Zeta-type opioid receptor) (7-60 protein).

KCNKA_HUMAN
θ value	0.0736092 (rank : 37)	NC score	0.174126 (rank : 35)
Query Neighborhood Hits	165	Target Neighborhood Hits	111	Shared Neighborhood Hits	46
SwissProt Accessions	P57789, Q8TDK7, Q8TDK8, Q9HB59	Gene names	KCNK10, TREK2
Domain Architecture
Description	Potassium channel subfamily K member 10 (Outward rectifying potassium channel protein TREK-2) (TREK-2 K(+) channel subunit).

KCND1_MOUSE
θ value	0.0961366 (rank : 38)	NC score	0.066370 (rank : 59)
Query Neighborhood Hits	165	Target Neighborhood Hits	165	Shared Neighborhood Hits	48
SwissProt Accessions	Q03719, Q8CC68	Gene names	Kcnd1
Domain Architecture
Description	Potassium voltage-gated channel subfamily D member 1 (Voltage-gated potassium channel subunit Kv4.1) (mShal).

KCNK3_HUMAN
θ value	0.0961366 (rank : 39)	NC score	0.175485 (rank : 34)
Query Neighborhood Hits	165	Target Neighborhood Hits	88	Shared Neighborhood Hits	46
SwissProt Accessions	O14649	Gene names	KCNK3, TASK, TASK1
Domain Architecture
Description	Potassium channel subfamily K member 3 (Acid-sensitive potassium channel protein TASK-1) (TWIK-related acid-sensitive K(+) channel 1) (Two pore potassium channel KT3.1).

KCNK6_HUMAN
θ value	0.0961366 (rank : 40)	NC score	0.173560 (rank : 36)
Query Neighborhood Hits	165	Target Neighborhood Hits	79	Shared Neighborhood Hits	44
SwissProt Accessions	Q9Y257, Q9HB47	Gene names	KCNK6, TOSS, TWIK2
Domain Architecture
Description	Potassium channel subfamily K member 6 (Inward rectifying potassium channel protein TWIK-2) (TWIK-originated similarity sequence).

ZAR1_MOUSE
θ value	0.0961366 (rank : 41)	NC score	0.031075 (rank : 86)
Query Neighborhood Hits	165	Target Neighborhood Hits	254	Shared Neighborhood Hits	10
SwissProt Accessions	Q80SU3	Gene names	Zar1
Domain Architecture	No domain graphic available
Description	Zygote arrest 1 (Oocyte-specific maternal effect factor).

NRG2_HUMAN
θ value	0.125558 (rank : 42)	NC score	0.033261 (rank : 84)
Query Neighborhood Hits	165	Target Neighborhood Hits	419	Shared Neighborhood Hits	18
SwissProt Accessions	O14511	Gene names	NRG2, NTAK
Domain Architecture
Description	Pro-neuregulin-2, membrane-bound isoform precursor (Pro-NRG2) [Contains: Neuregulin-2 (NRG-2) (Neural- and thymus-derived activator for ERBB kinases) (NTAK) (Divergent of neuregulin-1) (DON-1)].

KCNK3_MOUSE
θ value	0.163984 (rank : 43)	NC score	0.171821 (rank : 37)
Query Neighborhood Hits	165	Target Neighborhood Hits	93	Shared Neighborhood Hits	46
SwissProt Accessions	O35111, O35163	Gene names	Kcnk3, Ctbak, Task, Task1
Domain Architecture
Description	Potassium channel subfamily K member 3 (Acid-sensitive potassium channel protein TASK-1) (TWIK-related acid-sensitive K(+) channel 1) (Cardiac two-pore background K(+) channel) (cTBAK-1) (Two pore potassium channel KT3.1).

MY18B_HUMAN
θ value	0.163984 (rank : 44)	NC score	0.007395 (rank : 147)
Query Neighborhood Hits	165	Target Neighborhood Hits	1299	Shared Neighborhood Hits	21
SwissProt Accessions	Q8IUG5, Q8NDI8, Q8TE65, Q8WWS0, Q96KH2, Q96KR8, Q96KR9	Gene names	MYO18B
Domain Architecture
Description	Myosin-18B (Myosin XVIIIb).

ZN516_MOUSE
θ value	0.21417 (rank : 45)	NC score	0.009527 (rank : 138)
Query Neighborhood Hits	165	Target Neighborhood Hits	1197	Shared Neighborhood Hits	36
SwissProt Accessions	Q7TSH3	Gene names	Znf516, Kiaa0222, Zfp516
Domain Architecture
Description	Zinc finger protein 516.

KGP1A_HUMAN
θ value	0.279714 (rank : 46)	NC score	0.043407 (rank : 72)
Query Neighborhood Hits	165	Target Neighborhood Hits	901	Shared Neighborhood Hits	40
SwissProt Accessions	Q13976	Gene names	PRKG1, PRKGR1A
Domain Architecture
Description	cGMP-dependent protein kinase 1, alpha isozyme (EC 2.7.11.12) (CGK 1 alpha) (cGKI-alpha).

KGP1B_HUMAN
θ value	0.279714 (rank : 47)	NC score	0.043452 (rank : 71)
Query Neighborhood Hits	165	Target Neighborhood Hits	921	Shared Neighborhood Hits	40
SwissProt Accessions	P14619	Gene names	PRKG1, PRKG1B, PRKGR1B
Domain Architecture
Description	cGMP-dependent protein kinase 1, beta isozyme (EC 2.7.11.12) (cGK 1 beta) (cGKI-beta).

NCA11_MOUSE
θ value	0.279714 (rank : 48)	NC score	0.009923 (rank : 135)
Query Neighborhood Hits	165	Target Neighborhood Hits	661	Shared Neighborhood Hits	18
SwissProt Accessions	P13595, Q61949	Gene names	Ncam1, Ncam
Domain Architecture
Description	Neural cell adhesion molecule 1, 180 kDa isoform precursor (N-CAM 180) (NCAM-180).

HSF1_MOUSE
θ value	0.365318 (rank : 49)	NC score	0.028412 (rank : 89)
Query Neighborhood Hits	165	Target Neighborhood Hits	267	Shared Neighborhood Hits	16
SwissProt Accessions	P38532, O70462	Gene names	Hsf1
Domain Architecture
Description	Heat shock factor protein 1 (HSF 1) (Heat shock transcription factor 1) (HSTF 1).

KCND2_HUMAN
θ value	0.365318 (rank : 50)	NC score	0.058868 (rank : 63)
Query Neighborhood Hits	165	Target Neighborhood Hits	154	Shared Neighborhood Hits	45
SwissProt Accessions	Q9NZV8, O95012, O95021, Q9UBY7, Q9UN98, Q9UNH9	Gene names	KCND2, KIAA1044
Domain Architecture
Description	Potassium voltage-gated channel subfamily D member 2 (Voltage-gated potassium channel subunit Kv4.2).

KCND2_MOUSE
θ value	0.365318 (rank : 51)	NC score	0.058857 (rank : 64)
Query Neighborhood Hits	165	Target Neighborhood Hits	156	Shared Neighborhood Hits	45
SwissProt Accessions	Q9Z0V2, Q8BSK3, Q8CHB7, Q9JJ60	Gene names	Kcnd2, Kiaa1044
Domain Architecture
Description	Potassium voltage-gated channel subfamily D member 2 (Voltage-gated potassium channel subunit Kv4.2).

NRX2A_HUMAN
θ value	0.365318 (rank : 52)	NC score	0.027376 (rank : 91)
Query Neighborhood Hits	165	Target Neighborhood Hits	614	Shared Neighborhood Hits	19
SwissProt Accessions	Q9P2S2, Q9Y2D6	Gene names	NRXN2, KIAA0921
Domain Architecture
Description	Neurexin-2-alpha precursor (Neurexin II-alpha).

NRX2B_HUMAN
θ value	0.365318 (rank : 53)	NC score	0.040775 (rank : 74)
Query Neighborhood Hits	165	Target Neighborhood Hits	481	Shared Neighborhood Hits	17
SwissProt Accessions	P58401	Gene names	NRXN2
Domain Architecture	No domain graphic available
Description	Neurexin-2-beta precursor (Neurexin II-beta).

TCGAP_HUMAN
θ value	0.365318 (rank : 54)	NC score	0.021532 (rank : 102)
Query Neighborhood Hits	165	Target Neighborhood Hits	872	Shared Neighborhood Hits	33
SwissProt Accessions	O14559, O14552, O14560, Q6ZSP6, Q96CP3, Q9NT23	Gene names	SNX26, TCGAP
Domain Architecture
Description	TC10/CDC42 GTPase-activating protein (Sorting nexin-26).

KCND1_HUMAN
θ value	0.47712 (rank : 55)	NC score	0.060414 (rank : 60)
Query Neighborhood Hits	165	Target Neighborhood Hits	160	Shared Neighborhood Hits	45
SwissProt Accessions	Q9NSA2, O75671	Gene names	KCND1
Domain Architecture
Description	Potassium voltage-gated channel subfamily D member 1 (Voltage-gated potassium channel subunit Kv4.1).

KCNK4_HUMAN
θ value	0.47712 (rank : 56)	NC score	0.163263 (rank : 38)
Query Neighborhood Hits	165	Target Neighborhood Hits	109	Shared Neighborhood Hits	50
SwissProt Accessions	Q9NYG8, Q96T94	Gene names	KCNK4, TRAAK
Domain Architecture
Description	Potassium channel subfamily K member 4 (TWIK-related arachidonic acid- stimulated potassium channel protein) (TRAAK) (Two pore K(+) channel KT4.1).

KCNK4_MOUSE
θ value	0.47712 (rank : 57)	NC score	0.152683 (rank : 41)
Query Neighborhood Hits	165	Target Neighborhood Hits	118	Shared Neighborhood Hits	49
SwissProt Accessions	O88454	Gene names	Kcnk4, Traak
Domain Architecture	No domain graphic available
Description	Potassium channel subfamily K member 4 (TWIK-related arachidonic acid- stimulated potassium channel protein) (TRAAK).

RGS3_MOUSE
θ value	0.47712 (rank : 58)	NC score	0.034471 (rank : 80)
Query Neighborhood Hits	165	Target Neighborhood Hits	1621	Shared Neighborhood Hits	62
SwissProt Accessions	Q9DC04, Q5SRB1, Q5SRB4, Q5SRB8, Q8CEE3, Q8VI25, Q925G9, Q9JL22, Q9JL23, Q9QXA2	Gene names	Rgs3
Domain Architecture
Description	Regulator of G-protein signaling 3 (RGS3) (C2PA).

KAP0_MOUSE
θ value	0.62314 (rank : 59)	NC score	0.144674 (rank : 44)
Query Neighborhood Hits	165	Target Neighborhood Hits	48	Shared Neighborhood Hits	32
SwissProt Accessions	Q9DBC7, Q3UKU7, Q9JHR5, Q9JHR6	Gene names	Prkar1a
Domain Architecture	No domain graphic available
Description	cAMP-dependent protein kinase type I-alpha regulatory subunit.

KGP1B_MOUSE
θ value	0.62314 (rank : 60)	NC score	0.042998 (rank : 73)
Query Neighborhood Hits	165	Target Neighborhood Hits	922	Shared Neighborhood Hits	40
SwissProt Accessions	Q9Z0Z0	Gene names	Prkg1, Prkg1b, Prkgr1b
Domain Architecture
Description	cGMP-dependent protein kinase 1, beta isozyme (EC 2.7.11.12) (cGK 1 beta) (cGKI-beta).

MAGE1_HUMAN
θ value	0.62314 (rank : 61)	NC score	0.032958 (rank : 85)
Query Neighborhood Hits	165	Target Neighborhood Hits	1389	Shared Neighborhood Hits	62
SwissProt Accessions	Q9HCI5, Q86TG0, Q8TD92, Q9H216	Gene names	MAGEE1, HCA1, KIAA1587
Domain Architecture	No domain graphic available
Description	Melanoma-associated antigen E1 (MAGE-E1 antigen) (Hepatocellular carcinoma-associated protein 1).

SON_HUMAN
θ value	0.62314 (rank : 62)	NC score	0.019353 (rank : 104)
Query Neighborhood Hits	165	Target Neighborhood Hits	1568	Shared Neighborhood Hits	48
SwissProt Accessions	P18583, O14487, O95981, Q14120, Q9H7B1, Q9P070, Q9P072, Q9UKP9, Q9UPY0	Gene names	SON, C21orf50, DBP5, KIAA1019, NREBP
Domain Architecture
Description	SON protein (SON3) (Negative regulatory element-binding protein) (NRE- binding protein) (DBP-5) (Bax antagonist selected in saccharomyces 1) (BASS1).

TCOF_MOUSE
θ value	0.62314 (rank : 63)	NC score	0.023591 (rank : 95)
Query Neighborhood Hits	165	Target Neighborhood Hits	471	Shared Neighborhood Hits	14
SwissProt Accessions	O08784, O08857	Gene names	Tcof1
Domain Architecture
Description	Treacle protein (Treacher Collins syndrome protein homolog).

GP124_MOUSE
θ value	0.813845 (rank : 64)	NC score	0.008034 (rank : 143)
Query Neighborhood Hits	165	Target Neighborhood Hits	423	Shared Neighborhood Hits	9
SwissProt Accessions	Q91ZV8	Gene names	Gpr124, Tem5
Domain Architecture
Description	Probable G-protein coupled receptor 124 precursor (Tumor endothelial marker 5).

KCNK9_HUMAN
θ value	0.813845 (rank : 65)	NC score	0.146796 (rank : 43)
Query Neighborhood Hits	165	Target Neighborhood Hits	86	Shared Neighborhood Hits	44
SwissProt Accessions	Q9NPC2, Q2M290, Q540F2	Gene names	KCNK9, TASK3
Domain Architecture
Description	Potassium channel subfamily K member 9 (Acid-sensitive potassium channel protein TASK-3) (TWIK-related acid-sensitive K(+) channel 3) (Two pore potassium channel KT3.2).

KCNK9_MOUSE
θ value	0.813845 (rank : 66)	NC score	0.146938 (rank : 42)
Query Neighborhood Hits	165	Target Neighborhood Hits	86	Shared Neighborhood Hits	44
SwissProt Accessions	Q3LS21	Gene names	Kcnk9, Task3
Domain Architecture	No domain graphic available
Description	Potassium channel subfamily K member 9 (Acid-sensitive potassium channel protein TASK-3) (TWIK-related acid-sensitive K(+) channel 3).

KCNKD_MOUSE
θ value	0.813845 (rank : 67)	NC score	0.101106 (rank : 50)
Query Neighborhood Hits	165	Target Neighborhood Hits	51	Shared Neighborhood Hits	33
SwissProt Accessions	Q8R1P5	Gene names	Kcnk13
Domain Architecture
Description	Potassium channel subfamily K member 13 (Tandem pore domain halothane- inhibited potassium channel 1) (THIK-1).

NGN2_HUMAN
θ value	0.813845 (rank : 68)	NC score	0.009800 (rank : 136)
Query Neighborhood Hits	165	Target Neighborhood Hits	92	Shared Neighborhood Hits	2
SwissProt Accessions	Q9H2A3, Q8N416	Gene names	NEUROG2, NGN2
Domain Architecture	No domain graphic available
Description	Neurogenin 2.

ZNF31_HUMAN
θ value	0.813845 (rank : 69)	NC score	-0.002439 (rank : 170)
Query Neighborhood Hits	165	Target Neighborhood Hits	769	Shared Neighborhood Hits	10
SwissProt Accessions	P17040, Q96H84	Gene names	ZNF31, KOX29, ZNF360, ZSCAN20
Domain Architecture	No domain graphic available
Description	Zinc finger protein 31 (Zinc finger protein KOX29) (Zinc finger and SCAN domain-containing protein 20) (Zinc finger protein 360).

KAP0_HUMAN
θ value	1.06291 (rank : 70)	NC score	0.156057 (rank : 40)
Query Neighborhood Hits	165	Target Neighborhood Hits	52	Shared Neighborhood Hits	32
SwissProt Accessions	P10644, Q567S7	Gene names	PRKAR1A, PKR1, PRKAR1
Domain Architecture
Description	cAMP-dependent protein kinase type I-alpha regulatory subunit (Tissue- specific extinguisher 1) (TSE1).

PSL1_HUMAN
θ value	1.06291 (rank : 71)	NC score	0.040508 (rank : 76)
Query Neighborhood Hits	165	Target Neighborhood Hits	650	Shared Neighborhood Hits	34
SwissProt Accessions	Q8TCT7, O60365, Q567S3, Q8IUH9, Q9BUY6, Q9H3M4, Q9NPN2, Q9P1Z6	Gene names	SPPL2B, KIAA1532, PSL1
Domain Architecture
Description	Signal peptide peptidase-like 2B (EC 3.4.23.-) (Protein SPP-like 2B) (Protein SPPL2b) (Intramembrane protease 4) (IMP4) (Presenilin-like protein 1).

KCNKG_HUMAN
θ value	1.38821 (rank : 72)	NC score	0.160547 (rank : 39)
Query Neighborhood Hits	165	Target Neighborhood Hits	90	Shared Neighborhood Hits	44
SwissProt Accessions	Q96T55, Q5TCF3, Q9H591	Gene names	KCNK16, TALK1
Domain Architecture	No domain graphic available
Description	Potassium channel subfamily K member 16 (TWIK-related alkaline pH- activated K(+) channel 1) (2P domain potassium channel Talk-1).

SNPC4_HUMAN
θ value	1.38821 (rank : 73)	NC score	0.025312 (rank : 93)
Query Neighborhood Hits	165	Target Neighborhood Hits	589	Shared Neighborhood Hits	30
SwissProt Accessions	Q5SXM2, Q9Y6P7	Gene names	SNAPC4, SNAP190
Domain Architecture	No domain graphic available
Description	snRNA-activating protein complex subunit 4 (SNAPc subunit 4) (snRNA- activating protein complex 190 kDa subunit) (SNAPc 190 kDa subunit) (Proximal sequence element-binding transcription factor subunit alpha) (PSE-binding factor subunit alpha) (PTF subunit alpha).

TNKS1_HUMAN
θ value	1.38821 (rank : 74)	NC score	0.002738 (rank : 159)
Query Neighborhood Hits	165	Target Neighborhood Hits	477	Shared Neighborhood Hits	12
SwissProt Accessions	O95271, O95272	Gene names	TNKS, PARP5A, PARPL, TIN1, TINF1, TNKS1
Domain Architecture
Description	Tankyrase-1 (EC 2.4.2.30) (TANK1) (Tankyrase I) (TNKS-1) (TRF1- interacting ankyrin-related ADP-ribose polymerase).

CEND3_HUMAN
θ value	1.81305 (rank : 75)	NC score	0.007762 (rank : 144)
Query Neighborhood Hits	165	Target Neighborhood Hits	275	Shared Neighborhood Hits	13
SwissProt Accessions	Q8WWN8	Gene names	CENTD3, ARAP3
Domain Architecture	No domain graphic available
Description	Centaurin-delta 3 (Cnt-d3) (Arf-GAP, Rho-GAP, ankyrin repeat and pleckstrin homology domain-containing protein 3).

HGFA_HUMAN
θ value	1.81305 (rank : 76)	NC score	0.000975 (rank : 163)
Query Neighborhood Hits	165	Target Neighborhood Hits	436	Shared Neighborhood Hits	11
SwissProt Accessions	Q04756, Q14726	Gene names	HGFAC
Domain Architecture
Description	Hepatocyte growth factor activator precursor (EC 3.4.21.-) (HGF activator) (HGFA) [Contains: Hepatocyte growth factor activator short chain; Hepatocyte growth factor activator long chain].

KCNK1_HUMAN
θ value	1.81305 (rank : 77)	NC score	0.124690 (rank : 47)
Query Neighborhood Hits	165	Target Neighborhood Hits	68	Shared Neighborhood Hits	43
SwissProt Accessions	O00180, Q13307	Gene names	KCNK1, HOHO1, KCNO1, TWIK1
Domain Architecture	No domain graphic available
Description	Potassium channel subfamily K member 1 (Inward rectifying potassium channel protein TWIK-1) (Potassium channel KCNO1).

MNAB_HUMAN
θ value	1.81305 (rank : 78)	NC score	0.014176 (rank : 116)
Query Neighborhood Hits	165	Target Neighborhood Hits	196	Shared Neighborhood Hits	5
SwissProt Accessions	Q9HBD1, Q5JPD7, Q86ST6, Q8N3D6, Q96F27, Q9H5J2, Q9HBD2, Q9NWN9, Q9NXE1	Gene names	MNAB, RNF164
Domain Architecture	No domain graphic available
Description	Membrane-associated nucleic acid-binding protein (RING finger protein 164).

RGS14_HUMAN
θ value	1.81305 (rank : 79)	NC score	0.013127 (rank : 121)
Query Neighborhood Hits	165	Target Neighborhood Hits	77	Shared Neighborhood Hits	5
SwissProt Accessions	O43566, O43565, Q8TD62	Gene names	RGS14
Domain Architecture
Description	Regulator of G-protein signaling 14 (RGS14).

SEM5B_MOUSE
θ value	1.81305 (rank : 80)	NC score	0.004565 (rank : 153)
Query Neighborhood Hits	165	Target Neighborhood Hits	190	Shared Neighborhood Hits	6
SwissProt Accessions	Q60519	Gene names	Sema5b, Semag, SemG
Domain Architecture
Description	Semaphorin-5B precursor (Semaphorin G) (Sema G).

FOXN1_HUMAN
θ value	2.36792 (rank : 81)	NC score	0.016467 (rank : 108)
Query Neighborhood Hits	165	Target Neighborhood Hits	377	Shared Neighborhood Hits	18
SwissProt Accessions	O15353, O15352	Gene names	FOXN1, WHN
Domain Architecture
Description	Forkhead box protein N1 (Transcription factor winged-helix nude).

KAP1_HUMAN
θ value	2.36792 (rank : 82)	NC score	0.131616 (rank : 45)
Query Neighborhood Hits	165	Target Neighborhood Hits	58	Shared Neighborhood Hits	30
SwissProt Accessions	P31321	Gene names	PRKAR1B
Domain Architecture
Description	cAMP-dependent protein kinase type I-beta regulatory subunit.

KAP1_MOUSE
θ value	2.36792 (rank : 83)	NC score	0.129316 (rank : 46)
Query Neighborhood Hits	165	Target Neighborhood Hits	49	Shared Neighborhood Hits	30
SwissProt Accessions	P12849	Gene names	Prkar1b
Domain Architecture
Description	cAMP-dependent protein kinase type I-beta regulatory subunit.

KCND3_HUMAN
θ value	2.36792 (rank : 84)	NC score	0.055580 (rank : 66)
Query Neighborhood Hits	165	Target Neighborhood Hits	162	Shared Neighborhood Hits	44
SwissProt Accessions	Q9UK17, O60576, O60577, Q5T0M0, Q9UH85, Q9UH86, Q9UK16	Gene names	KCND3
Domain Architecture
Description	Potassium voltage-gated channel subfamily D member 3 (Voltage-gated potassium channel subunit Kv4.3).

KCND3_MOUSE
θ value	2.36792 (rank : 85)	NC score	0.055593 (rank : 65)
Query Neighborhood Hits	165	Target Neighborhood Hits	162	Shared Neighborhood Hits	44
SwissProt Accessions	Q9Z0V1, Q8CC44, Q9Z0V0	Gene names	Kcnd3
Domain Architecture
Description	Potassium voltage-gated channel subfamily D member 3 (Voltage-gated potassium channel subunit Kv4.3).

KCNK5_HUMAN
θ value	2.36792 (rank : 86)	NC score	0.123696 (rank : 48)
Query Neighborhood Hits	165	Target Neighborhood Hits	102	Shared Neighborhood Hits	48
SwissProt Accessions	O95279	Gene names	KCNK5, TASK2
Domain Architecture
Description	Potassium channel subfamily K member 5 (Acid-sensitive potassium channel protein TASK-2) (TWIK-related acid-sensitive K(+) channel 2).

SEM5B_HUMAN
θ value	2.36792 (rank : 87)	NC score	0.004381 (rank : 155)
Query Neighborhood Hits	165	Target Neighborhood Hits	178	Shared Neighborhood Hits	6
SwissProt Accessions	Q9P283, Q6UY12	Gene names	SEMA5B, KIAA1445
Domain Architecture
Description	Semaphorin-5B precursor.

TCOF_HUMAN
θ value	2.36792 (rank : 88)	NC score	0.022634 (rank : 98)
Query Neighborhood Hits	165	Target Neighborhood Hits	543	Shared Neighborhood Hits	23
SwissProt Accessions	Q13428, Q99408, Q99860	Gene names	TCOF1
Domain Architecture
Description	Treacle protein (Treacher Collins syndrome protein).

TOPRS_MOUSE
θ value	2.36792 (rank : 89)	NC score	0.021598 (rank : 101)
Query Neighborhood Hits	165	Target Neighborhood Hits	263	Shared Neighborhood Hits	6
SwissProt Accessions	Q80Z37, Q3U5B5, Q3UPZ1, Q3USN3, Q3UZ55, Q8BXP2, Q8CFF5, Q8CGC8, Q920L3	Gene names	Topors
Domain Architecture	No domain graphic available
Description	Ubiquitin-protein E3 ligase Topors (EC 6.3.2.-) (SUMO1-protein E3 ligase Topors) (Topoisomerase I-binding RING finger protein) (Topoisomerase I-binding arginine/serine-rich protein) (Tumor suppressor p53-binding protein 3) (p53-binding protein 3) (p53BP3).

ADRM1_HUMAN
θ value	3.0926 (rank : 90)	NC score	0.022255 (rank : 100)
Query Neighborhood Hits	165	Target Neighborhood Hits	81	Shared Neighborhood Hits	10
SwissProt Accessions	Q16186, Q9H1P2	Gene names	ADRM1, GP110
Domain Architecture
Description	Adhesion-regulating molecule 1 precursor (110 kDa cell membrane glycoprotein) (Gp110).

ATPD_HUMAN
θ value	3.0926 (rank : 91)	NC score	0.027421 (rank : 90)
Query Neighborhood Hits	165	Target Neighborhood Hits	6	Shared Neighborhood Hits	3
SwissProt Accessions	P30049	Gene names	ATP5D
Domain Architecture
Description	ATP synthase delta chain, mitochondrial precursor (EC 3.6.3.14).

CT151_HUMAN
θ value	3.0926 (rank : 92)	NC score	0.013425 (rank : 120)
Query Neighborhood Hits	165	Target Neighborhood Hits	382	Shared Neighborhood Hits	15
SwissProt Accessions	Q8NC74, Q8N4Z9, Q9BR75, Q9H0Y9	Gene names	C20orf151
Domain Architecture
Description	Uncharacterized protein C20orf151.

IL4RA_HUMAN
θ value	3.0926 (rank : 93)	NC score	0.014877 (rank : 114)
Query Neighborhood Hits	165	Target Neighborhood Hits	144	Shared Neighborhood Hits	11
SwissProt Accessions	P24394, Q96P01, Q9H181, Q9H182, Q9H183, Q9H184, Q9H185, Q9H186, Q9H187, Q9H188	Gene names	IL4R, 582J2.1, IL4RA
Domain Architecture
Description	Interleukin-4 receptor alpha chain precursor (IL-4R-alpha) (CD124 antigen) [Contains: Soluble interleukin-4 receptor alpha chain (sIL4Ralpha/prot) (IL-4-binding protein) (IL4-BP)].

KCMA1_HUMAN
θ value	3.0926 (rank : 94)	NC score	0.059802 (rank : 62)
Query Neighborhood Hits	165	Target Neighborhood Hits	96	Shared Neighborhood Hits	37
SwissProt Accessions	Q12791, Q12886, Q12917, Q12921, Q12960, Q13150, Q96LG8, Q9UBB0, Q9UQK6	Gene names	KCNMA1, KCNMA
Domain Architecture
Description	Calcium-activated potassium channel subunit alpha 1 (Calcium-activated potassium channel, subfamily M subunit alpha 1) (Maxi K channel) (MaxiK) (BK channel) (K(VCA)alpha) (BKCA alpha) (KCa1.1) (Slowpoke homolog) (Slo homolog) (Slo-alpha) (Slo1) (hSlo).

KCMA1_MOUSE
θ value	3.0926 (rank : 95)	NC score	0.059909 (rank : 61)
Query Neighborhood Hits	165	Target Neighborhood Hits	94	Shared Neighborhood Hits	37
SwissProt Accessions	Q08460, Q64703, Q8VHF1, Q9R196	Gene names	Kcnma1, Kcnma
Domain Architecture
Description	Calcium-activated potassium channel subunit alpha 1 (Calcium-activated potassium channel, subfamily M subunit alpha 1) (Maxi K channel) (MaxiK) (BK channel) (K(VCA)alpha) (BKCA alpha) (KCa1.1) (Slowpoke homolog) (Slo homolog) (Slo-alpha) (Slo1) (mSlo) (mSlo1).

KCNK1_MOUSE
θ value	3.0926 (rank : 96)	NC score	0.120023 (rank : 49)
Query Neighborhood Hits	165	Target Neighborhood Hits	70	Shared Neighborhood Hits	41
SwissProt Accessions	O08581	Gene names	Kcnk1
Domain Architecture
Description	Potassium channel subfamily K member 1 (Inward rectifying potassium channel protein TWIK-1).

KCNQ2_HUMAN
θ value	3.0926 (rank : 97)	NC score	0.040728 (rank : 75)
Query Neighborhood Hits	165	Target Neighborhood Hits	114	Shared Neighborhood Hits	42
SwissProt Accessions	O43526, O43796, O75580, O95845, Q5VYT8, Q96J59, Q99454	Gene names	KCNQ2
Domain Architecture
Description	Potassium voltage-gated channel subfamily KQT member 2 (Voltage-gated potassium channel subunit Kv7.2) (Neuroblastoma-specific potassium channel subunit alpha KvLQT2) (KQT-like 2).

KCNQ2_MOUSE
θ value	3.0926 (rank : 98)	NC score	0.039826 (rank : 78)
Query Neighborhood Hits	165	Target Neighborhood Hits	163	Shared Neighborhood Hits	45
SwissProt Accessions	Q9Z351, Q8R498, Q9QWN9, Q9Z342, Q9Z343, Q9Z344, Q9Z345, Q9Z346, Q9Z347, Q9Z348, Q9Z349, Q9Z350	Gene names	Kcnq2, Kqt2
Domain Architecture
Description	Potassium voltage-gated channel subfamily KQT member 2 (Voltage-gated potassium channel subunit Kv7.2) (Potassium channel subunit alpha KvLQT2) (KQT-like 2).

ONEC2_HUMAN
θ value	3.0926 (rank : 99)	NC score	0.007660 (rank : 145)
Query Neighborhood Hits	165	Target Neighborhood Hits	115	Shared Neighborhood Hits	2
SwissProt Accessions	O95948	Gene names	ONECUT2
Domain Architecture
Description	One cut domain family member 2 (Transcription factor ONECUT-2) (OC-2).

PER1_MOUSE
θ value	3.0926 (rank : 100)	NC score	0.009729 (rank : 137)
Query Neighborhood Hits	165	Target Neighborhood Hits	235	Shared Neighborhood Hits	16
SwissProt Accessions	O35973	Gene names	Per1, Per, Rigui
Domain Architecture
Description	Period circadian protein 1 (Circadian pacemaker protein Rigui) (mPER) (M-Rigui).

PRAX_HUMAN
θ value	3.0926 (rank : 101)	NC score	0.013026 (rank : 122)
Query Neighborhood Hits	165	Target Neighborhood Hits	215	Shared Neighborhood Hits	9
SwissProt Accessions	Q9BXM0, Q9BXL9, Q9HCF2	Gene names	PRX, KIAA1620
Domain Architecture
Description	Periaxin.

PRGR_HUMAN
θ value	3.0926 (rank : 102)	NC score	0.003471 (rank : 157)
Query Neighborhood Hits	165	Target Neighborhood Hits	163	Shared Neighborhood Hits	11
SwissProt Accessions	P06401, Q9UPF7	Gene names	PGR, NR3C3
Domain Architecture
Description	Progesterone receptor (PR).

VINC_HUMAN
θ value	3.0926 (rank : 103)	NC score	0.016132 (rank : 109)
Query Neighborhood Hits	165	Target Neighborhood Hits	145	Shared Neighborhood Hits	8
SwissProt Accessions	P18206, Q16450, Q5SWX2, Q7Z3B8, Q8IXU7	Gene names	VCL
Domain Architecture
Description	Vinculin (Metavinculin).

VINC_MOUSE
θ value	3.0926 (rank : 104)	NC score	0.015044 (rank : 113)
Query Neighborhood Hits	165	Target Neighborhood Hits	135	Shared Neighborhood Hits	8
SwissProt Accessions	Q64727, Q8BP32, Q8BS46, Q922C5, Q922D9	Gene names	Vcl
Domain Architecture
Description	Vinculin (Metavinculin).

ZP1_MOUSE
θ value	3.0926 (rank : 105)	NC score	0.014285 (rank : 115)
Query Neighborhood Hits	165	Target Neighborhood Hits	43	Shared Neighborhood Hits	3
SwissProt Accessions	Q62005, Q62016	Gene names	Zp1
Domain Architecture
Description	Zona pellucida sperm-binding protein 1 precursor (Zona pellucida glycoprotein 1) (Zp-1).

AFF1_MOUSE
θ value	4.03905 (rank : 106)	NC score	0.013841 (rank : 118)
Query Neighborhood Hits	165	Target Neighborhood Hits	351	Shared Neighborhood Hits	19
SwissProt Accessions	O88573	Gene names	Aff1, Mllt2, Mllt2h
Domain Architecture
Description	AF4/FMR2 family member 1 (Protein AF-4) (Proto-oncogene AF4).

CI150_MOUSE
θ value	4.03905 (rank : 107)	NC score	0.020453 (rank : 103)
Query Neighborhood Hits	165	Target Neighborhood Hits	10	Shared Neighborhood Hits	3
SwissProt Accessions	Q8K2P1, Q9D150	Gene names	D4Bwg0951e
Domain Architecture	No domain graphic available
Description	Protein C9orf150 homolog.

ELF2_MOUSE
θ value	4.03905 (rank : 108)	NC score	0.006403 (rank : 149)
Query Neighborhood Hits	165	Target Neighborhood Hits	81	Shared Neighborhood Hits	5
SwissProt Accessions	Q9JHC9, Q6NST2, Q8BTX8, Q9JHC7, Q9JHC8, Q9JHD0	Gene names	Elf2, Nerf
Domain Architecture	No domain graphic available
Description	ETS-related transcription factor Elf-2 (E74-like factor 2) (New ETS- related factor).

FOXO4_MOUSE
θ value	4.03905 (rank : 109)	NC score	0.004479 (rank : 154)
Query Neighborhood Hits	165	Target Neighborhood Hits	168	Shared Neighborhood Hits	9
SwissProt Accessions	Q9WVH3	Gene names	Mllt7, Afx, Afx1, Fkhr3, Foxo4
Domain Architecture
Description	Fork head domain transcription factor AFX1 (Afxh) (Forkhead box protein O4).

GLIS1_HUMAN
θ value	4.03905 (rank : 110)	NC score	-0.002393 (rank : 169)
Query Neighborhood Hits	165	Target Neighborhood Hits	748	Shared Neighborhood Hits	12
SwissProt Accessions	Q8NBF1, Q8N9V9	Gene names	GLIS1
Domain Architecture	No domain graphic available
Description	Zinc finger protein GLIS1 (GLI-similar 1).

GNAS1_HUMAN
θ value	4.03905 (rank : 111)	NC score	0.011769 (rank : 125)
Query Neighborhood Hits	165	Target Neighborhood Hits	278	Shared Neighborhood Hits	19
SwissProt Accessions	Q5JWF2, O75684, O75685, Q5JW67, Q5JWF1, Q9NY42	Gene names	GNAS, GNAS1
Domain Architecture	No domain graphic available
Description	Guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas (Adenylate cyclase-stimulating G alpha protein) (Extra large alphas protein) (XLalphas).

JIP2_HUMAN
θ value	4.03905 (rank : 112)	NC score	0.010537 (rank : 132)
Query Neighborhood Hits	165	Target Neighborhood Hits	288	Shared Neighborhood Hits	11
SwissProt Accessions	Q13387, Q96G62, Q99771, Q9NZ59, Q9UKQ4	Gene names	MAPK8IP2, IB2, JIP2
Domain Architecture
Description	C-jun-amino-terminal kinase-interacting protein 2 (JNK-interacting protein 2) (JIP-2) (JNK MAP kinase scaffold protein 2) (Islet-brain-2) (IB-2) (Mitogen-activated protein kinase 8-interacting protein 2).

KCNKC_HUMAN
θ value	4.03905 (rank : 113)	NC score	0.078216 (rank : 56)
Query Neighborhood Hits	165	Target Neighborhood Hits	51	Shared Neighborhood Hits	32
SwissProt Accessions	Q9HB15	Gene names	KCNK12
Domain Architecture	No domain graphic available
Description	Potassium channel subfamily K member 12 (Tandem pore domain halothane- inhibited potassium channel 2) (THIK-2).

KCNQ3_MOUSE
θ value	4.03905 (rank : 114)	NC score	0.055091 (rank : 67)
Query Neighborhood Hits	165	Target Neighborhood Hits	105	Shared Neighborhood Hits	42
SwissProt Accessions	Q8K3F6	Gene names	Kcnq3
Domain Architecture	No domain graphic available
Description	Potassium voltage-gated channel subfamily KQT member 3 (Voltage-gated potassium channel subunit Kv7.3) (Potassium channel subunit alpha KvLQT3) (KQT-like 3).

RPGF4_HUMAN
θ value	4.03905 (rank : 115)	NC score	0.039516 (rank : 79)
Query Neighborhood Hits	165	Target Neighborhood Hits	88	Shared Neighborhood Hits	20
SwissProt Accessions	Q8WZA2, O95636, Q8IXK6, Q8TAA4	Gene names	RAPGEF4, CGEF2, EPAC2
Domain Architecture
Description	Rap guanine nucleotide exchange factor 4 (cAMP-regulated guanine nucleotide exchange factor II) (cAMP-GEFII) (Exchange factor directly activated by cAMP 2) (Epac 2).

RPGF4_MOUSE
θ value	4.03905 (rank : 116)	NC score	0.043636 (rank : 70)
Query Neighborhood Hits	165	Target Neighborhood Hits	80	Shared Neighborhood Hits	20
SwissProt Accessions	Q9EQZ6, Q8VIP9, Q9CW52, Q9Z1P0	Gene names	Rapgef4, Cgef2, Epac2
Domain Architecture
Description	Rap guanine nucleotide exchange factor 4 (cAMP-regulated guanine nucleotide exchange factor II) (cAMP-GEFII) (Exchange factor directly activated by cAMP 2) (Epac 2) (cAMP-dependent Rap1 guanine-nucleotide exchange factor).

SRRM1_HUMAN
θ value	4.03905 (rank : 117)	NC score	0.026321 (rank : 92)
Query Neighborhood Hits	165	Target Neighborhood Hits	690	Shared Neighborhood Hits	28
SwissProt Accessions	Q8IYB3, O60585, Q5VVN4	Gene names	SRRM1, SRM160
Domain Architecture	No domain graphic available
Description	Serine/arginine repetitive matrix protein 1 (Ser/Arg-related nuclear matrix protein) (SR-related nuclear matrix protein of 160 kDa) (SRm160).

SRRM2_HUMAN
θ value	4.03905 (rank : 118)	NC score	0.014064 (rank : 117)
Query Neighborhood Hits	165	Target Neighborhood Hits	1296	Shared Neighborhood Hits	40
SwissProt Accessions	Q9UQ35, O15038, O94803, Q6NSL3, Q6PIM3, Q6PK40, Q8IW17, Q96GY7, Q9P0G1, Q9UHA8, Q9UQ36, Q9UQ37, Q9UQ38, Q9UQ40	Gene names	SRRM2, KIAA0324, SRL300, SRM300
Domain Architecture	No domain graphic available
Description	Serine/arginine repetitive matrix protein 2 (Serine/arginine-rich splicing factor-related nuclear matrix protein of 300 kDa) (Ser/Arg- related nuclear matrix protein) (SR-related nuclear matrix protein of 300 kDa) (Splicing coactivator subunit SRm300) (300 kDa nuclear matrix antigen).

3BHS7_MOUSE
θ value	5.27518 (rank : 119)	NC score	0.011100 (rank : 130)
Query Neighborhood Hits	165	Target Neighborhood Hits	21	Shared Neighborhood Hits	4
SwissProt Accessions	Q9EQC1	Gene names	Hsd3b7
Domain Architecture
Description	3 beta-hydroxysteroid dehydrogenase type 7 (3 beta-hydroxysteroid dehydrogenase type VII) (3Beta-HSD VII) (3-beta-hydroxy-delta(5)-C27 steroid oxidoreductase) (EC 1.1.1.-) (C(27) 3beta-HSD).

AF17_HUMAN
θ value	5.27518 (rank : 120)	NC score	0.011735 (rank : 126)
Query Neighborhood Hits	165	Target Neighborhood Hits	230	Shared Neighborhood Hits	15
SwissProt Accessions	P55198, Q9UF49	Gene names	MLLT6, AF17
Domain Architecture
Description	Protein AF-17.

KCNKD_HUMAN
θ value	5.27518 (rank : 121)	NC score	0.080263 (rank : 55)
Query Neighborhood Hits	165	Target Neighborhood Hits	58	Shared Neighborhood Hits	33
SwissProt Accessions	Q9HB14, Q96E79	Gene names	KCNK13
Domain Architecture
Description	Potassium channel subfamily K member 13 (Tandem pore domain halothane- inhibited potassium channel 1) (THIK-1).

KCNN4_HUMAN
θ value	5.27518 (rank : 122)	NC score	0.034263 (rank : 81)
Query Neighborhood Hits	165	Target Neighborhood Hits	90	Shared Neighborhood Hits	36
SwissProt Accessions	O15554	Gene names	KCNN4, IK1, IKCA1, KCA4, SK4
Domain Architecture
Description	Intermediate conductance calcium-activated potassium channel protein 4 (SK4) (KCa4) (IK1) (IKCa1) (Putative Gardos channel).

LTB1L_HUMAN
θ value	5.27518 (rank : 123)	NC score	-0.000323 (rank : 165)
Query Neighborhood Hits	165	Target Neighborhood Hits	553	Shared Neighborhood Hits	9
SwissProt Accessions	Q14766	Gene names	LTBP1
Domain Architecture
Description	Latent-transforming growth factor beta-binding protein, isoform 1L precursor (LTBP-1) (Transforming growth factor beta-1-binding protein 1) (TGF-beta1-BP-1).

MK07_MOUSE
θ value	5.27518 (rank : 124)	NC score	-0.002506 (rank : 171)
Query Neighborhood Hits	165	Target Neighborhood Hits	1054	Shared Neighborhood Hits	23
SwissProt Accessions	Q9WVS8	Gene names	Mapk7, Erk5
Domain Architecture
Description	Mitogen-activated protein kinase 7 (EC 2.7.11.24) (Extracellular signal-regulated kinase 5) (ERK-5) (BMK1 kinase).

PRAX_MOUSE
θ value	5.27518 (rank : 125)	NC score	0.012764 (rank : 123)
Query Neighborhood Hits	165	Target Neighborhood Hits	199	Shared Neighborhood Hits	10
SwissProt Accessions	O55103, O55104	Gene names	Prx
Domain Architecture
Description	Periaxin.

T22D4_HUMAN
θ value	5.27518 (rank : 126)	NC score	0.023336 (rank : 96)
Query Neighborhood Hits	165	Target Neighborhood Hits	403	Shared Neighborhood Hits	26
SwissProt Accessions	Q9Y3Q8	Gene names	TSC22D4, TILZ2
Domain Architecture
Description	TSC22 domain family protein 4 (TSC22-related-inducible leucine zipper protein 2) (Tsc-22-like protein THG-1).

WBP1_MOUSE
θ value	5.27518 (rank : 127)	NC score	0.009469 (rank : 139)
Query Neighborhood Hits	165	Target Neighborhood Hits	12	Shared Neighborhood Hits	2
SwissProt Accessions	P97764, Q8WUP5, Q99J20	Gene names	Wbp1
Domain Architecture	No domain graphic available
Description	WW domain-binding protein 1 (WBP-1).

AP180_MOUSE
θ value	6.88961 (rank : 128)	NC score	0.008234 (rank : 142)
Query Neighborhood Hits	165	Target Neighborhood Hits	194	Shared Neighborhood Hits	11
SwissProt Accessions	Q61548, Q61547	Gene names	Snap91
Domain Architecture
Description	Clathrin coat assembly protein AP180 (Clathrin coat-associated protein AP180) (91 kDa synaptosomal-associated protein) (Phosphoprotein F1- 20).

AT10D_HUMAN
θ value	6.88961 (rank : 129)	NC score	0.001813 (rank : 161)
Query Neighborhood Hits	165	Target Neighborhood Hits	69	Shared Neighborhood Hits	2
SwissProt Accessions	Q9P241, Q8NC70, Q96SR3	Gene names	ATP10D, KIAA1487
Domain Architecture
Description	Probable phospholipid-transporting ATPase VD (EC 3.6.3.1) (ATPVD).

BC11B_HUMAN
θ value	6.88961 (rank : 130)	NC score	-0.001693 (rank : 168)
Query Neighborhood Hits	165	Target Neighborhood Hits	761	Shared Neighborhood Hits	11
SwissProt Accessions	Q9C0K0, Q9H162	Gene names	BCL11B, CTIP2, RIT1
Domain Architecture	No domain graphic available
Description	B-cell lymphoma/leukemia 11B (B-cell CLL/lymphoma 11B) (Radiation- induced tumor suppressor gene 1 protein) (hRit1) (COUP-TF-interacting protein 2).

BC11B_MOUSE
θ value	6.88961 (rank : 131)	NC score	-0.001595 (rank : 167)
Query Neighborhood Hits	165	Target Neighborhood Hits	767	Shared Neighborhood Hits	13
SwissProt Accessions	Q99PV8, Q8C2I1, Q99PV6, Q99PV7, Q9JLF8	Gene names	Bcl11b, Ctip2, Rit1
Domain Architecture	No domain graphic available
Description	B-cell lymphoma/leukemia 11B (B-cell CLL/lymphoma 11B) (Radiation- induced tumor suppressor gene 1 protein) (mRit1) (COUP-TF-interacting protein 2).

CA106_MOUSE
θ value	6.88961 (rank : 132)	NC score	0.023246 (rank : 97)
Query Neighborhood Hits	165	Target Neighborhood Hits	89	Shared Neighborhood Hits	7
SwissProt Accessions	Q7TN12, Q7TN27, Q8BGK3	Gene names
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C1orf106 homolog.

CAC1B_MOUSE
θ value	6.88961 (rank : 133)	NC score	0.011654 (rank : 129)
Query Neighborhood Hits	165	Target Neighborhood Hits	351	Shared Neighborhood Hits	29
SwissProt Accessions	O55017, Q60609	Gene names	Cacna1b, Cach5, Cacnl1a5, Cchn1a
Domain Architecture
Description	Voltage-dependent N-type calcium channel subunit alpha-1B (Voltage- gated calcium channel subunit alpha Cav2.2) (Calcium channel, L type, alpha-1 polypeptide isoform 5) (Brain calcium channel III) (BIII).

CBL_HUMAN
θ value	6.88961 (rank : 134)	NC score	0.010355 (rank : 133)
Query Neighborhood Hits	165	Target Neighborhood Hits	353	Shared Neighborhood Hits	15
SwissProt Accessions	P22681	Gene names	CBL, CBL2, RNF55
Domain Architecture
Description	E3 ubiquitin-protein ligase CBL (EC 6.3.2.-) (Signal transduction protein CBL) (Proto-oncogene c-CBL) (Casitas B-lineage lymphoma proto- oncogene) (RING finger protein 55).

DDX51_HUMAN
θ value	6.88961 (rank : 135)	NC score	0.002241 (rank : 160)
Query Neighborhood Hits	165	Target Neighborhood Hits	332	Shared Neighborhood Hits	10
SwissProt Accessions	Q8N8A6, Q5CZ71, Q8IXK5, Q96ED1	Gene names	DDX51
Domain Architecture	No domain graphic available
Description	ATP-dependent RNA helicase DDX51 (EC 3.6.1.-) (DEAD box protein 51).

ELF2_HUMAN
θ value	6.88961 (rank : 136)	NC score	0.005310 (rank : 150)
Query Neighborhood Hits	165	Target Neighborhood Hits	78	Shared Neighborhood Hits	3
SwissProt Accessions	Q15723, Q15724, Q15725, Q6P1K5	Gene names	ELF2, NERF
Domain Architecture	No domain graphic available
Description	ETS-related transcription factor Elf-2 (E74-like factor 2) (New ETS- related factor).

FOG1_MOUSE
θ value	6.88961 (rank : 137)	NC score	0.004590 (rank : 152)
Query Neighborhood Hits	165	Target Neighborhood Hits	1237	Shared Neighborhood Hits	38
SwissProt Accessions	O35615	Gene names	Zfpm1, Fog, Fog1
Domain Architecture	No domain graphic available
Description	Zinc finger protein ZFPM1 (Zinc finger protein multitype 1) (Friend of GATA protein 1) (Friend of GATA-1) (FOG-1).

IF4G1_HUMAN
θ value	6.88961 (rank : 138)	NC score	0.010125 (rank : 134)
Query Neighborhood Hits	165	Target Neighborhood Hits	347	Shared Neighborhood Hits	20
SwissProt Accessions	Q04637, O43177, O95066, Q5HYG0, Q6ZN21, Q8N102	Gene names	EIF4G1, EIF4G, EIF4GI
Domain Architecture
Description	Eukaryotic translation initiation factor 4 gamma 1 (eIF-4-gamma 1) (eIF-4G1) (eIF-4G 1) (p220).

KCNN4_MOUSE
θ value	6.88961 (rank : 139)	NC score	0.030892 (rank : 87)
Query Neighborhood Hits	165	Target Neighborhood Hits	85	Shared Neighborhood Hits	37
SwissProt Accessions	O89109, Q3U1J8, Q9CY39	Gene names	Kcnn4
Domain Architecture
Description	Intermediate conductance calcium-activated potassium channel protein 4 (SK4) (KCa4) (IK1).

KCNQ3_HUMAN
θ value	6.88961 (rank : 140)	NC score	0.052958 (rank : 69)
Query Neighborhood Hits	165	Target Neighborhood Hits	114	Shared Neighborhood Hits	42
SwissProt Accessions	O43525	Gene names	KCNQ3
Domain Architecture
Description	Potassium voltage-gated channel subfamily KQT member 3 (Voltage-gated potassium channel subunit Kv7.3) (Potassium channel subunit alpha KvLQT3) (KQT-like 3).

MAST4_HUMAN
θ value	6.88961 (rank : 141)	NC score	0.003584 (rank : 156)
Query Neighborhood Hits	165	Target Neighborhood Hits	1804	Shared Neighborhood Hits	49
SwissProt Accessions	O15021, Q6ZN07, Q96LY3	Gene names	MAST4, KIAA0303
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase 4 (EC 2.7.11.1).

NACAM_MOUSE
θ value	6.88961 (rank : 142)	NC score	0.033393 (rank : 83)
Query Neighborhood Hits	165	Target Neighborhood Hits	1866	Shared Neighborhood Hits	65
SwissProt Accessions	P70670	Gene names	Naca
Domain Architecture	No domain graphic available
Description	Nascent polypeptide-associated complex subunit alpha, muscle-specific form (Alpha-NAC, muscle-specific form).

PHLPP_HUMAN
θ value	6.88961 (rank : 143)	NC score	0.009336 (rank : 141)
Query Neighborhood Hits	165	Target Neighborhood Hits	604	Shared Neighborhood Hits	21
SwissProt Accessions	O60346, Q641Q7, Q6P4C4, Q6PJI6, Q86TN6, Q96FK2, Q9NUY1	Gene names	PHLPP, KIAA0606, PLEKHE1, SCOP
Domain Architecture	No domain graphic available
Description	PH domain leucine-rich repeat-containing protein phosphatase (EC 3.1.3.16) (PH domain leucine-rich repeat protein phosphatase) (Pleckstrin homology domain-containing family E protein 1) (Suprachiasmatic nucleus circadian oscillatory protein) (hSCOP).

REL1_MOUSE
θ value	6.88961 (rank : 144)	NC score	0.015653 (rank : 110)
Query Neighborhood Hits	165	Target Neighborhood Hits	11	Shared Neighborhood Hits	3
SwissProt Accessions	P47932	Gene names	Rln1, Rln, Rlx
Domain Architecture
Description	Prorelaxin 1 precursor [Contains: Relaxin B chain; Relaxin A chain].

RP1L1_MOUSE
θ value	6.88961 (rank : 145)	NC score	0.010931 (rank : 131)
Query Neighborhood Hits	165	Target Neighborhood Hits	170	Shared Neighborhood Hits	11
SwissProt Accessions	Q8CGM2, Q8K0I4	Gene names	Rp1l1, Rp1hl1
Domain Architecture
Description	Retinitis pigmentosa 1-like 1 protein (Retinitis pigmentosa 1-like protein 1).

SYNG_HUMAN
θ value	6.88961 (rank : 146)	NC score	0.009433 (rank : 140)
Query Neighborhood Hits	165	Target Neighborhood Hits	160	Shared Neighborhood Hits	10
SwissProt Accessions	Q9UMZ2, Q6ZT17	Gene names	AP1GBP1, SYNG
Domain Architecture	No domain graphic available
Description	AP1 subunit gamma-binding protein 1 (Gamma-synergin).

TLN2_MOUSE
θ value	6.88961 (rank : 147)	NC score	0.003273 (rank : 158)
Query Neighborhood Hits	165	Target Neighborhood Hits	149	Shared Neighborhood Hits	4
SwissProt Accessions	Q71LX4, Q8BWK0	Gene names	Tln2
Domain Architecture	No domain graphic available
Description	Talin-2.

TMPSD_HUMAN
θ value	6.88961 (rank : 148)	NC score	0.000629 (rank : 164)
Query Neighborhood Hits	165	Target Neighborhood Hits	333	Shared Neighborhood Hits	15
SwissProt Accessions	Q9BYE2, Q86YM4, Q96JY8, Q9BYE1	Gene names	TMPRSS13, MSP, TMPRSS11
Domain Architecture	No domain graphic available
Description	Transmembrane protease, serine 13 (EC 3.4.21.-) (Mosaic serine protease) (Membrane-type mosaic serine protease).

TOPRS_HUMAN
θ value	6.88961 (rank : 149)	NC score	0.012271 (rank : 124)
Query Neighborhood Hits	165	Target Neighborhood Hits	286	Shared Neighborhood Hits	6
SwissProt Accessions	Q9NS56, O43273, Q6P987, Q9NS55, Q9UNR9	Gene names	TOPORS, LUN, TP53BPL
Domain Architecture	No domain graphic available
Description	Ubiquitin-protein E3 ligase Topors (EC 6.3.2.-) (SUMO1-protein E3 ligase Topors) (Topoisomerase I-binding RING finger protein) (Topoisomerase I-binding arginine/serine-rich protein) (Tumor suppressor p53-binding protein 3) (p53-binding protein 3) (p53BP3).

WASIP_HUMAN
θ value	6.88961 (rank : 150)	NC score	0.013821 (rank : 119)
Query Neighborhood Hits	165	Target Neighborhood Hits	458	Shared Neighborhood Hits	30
SwissProt Accessions	O43516, Q15220, Q6MZU9, Q9BU37, Q9UNP1	Gene names	WASPIP, WIP
Domain Architecture	No domain graphic available
Description	Wiskott-Aldrich syndrome protein-interacting protein (WASP-interacting protein) (PRPL-2 protein).

ZN409_HUMAN
θ value	6.88961 (rank : 151)	NC score	0.005118 (rank : 151)
Query Neighborhood Hits	165	Target Neighborhood Hits	842	Shared Neighborhood Hits	20
SwissProt Accessions	Q9UPU6	Gene names	ZNF409, KIAA1056
Domain Architecture	No domain graphic available
Description	Zinc finger protein 409.

ABD12_HUMAN
θ value	8.99809 (rank : 152)	NC score	0.011697 (rank : 127)
Query Neighborhood Hits	165	Target Neighborhood Hits	10	Shared Neighborhood Hits	4
SwissProt Accessions	Q8N2K0, Q5T710, Q96CR1, Q9BX05, Q9NPX7, Q9UFV6	Gene names	Abhd12, C20orf22
Domain Architecture
Description	Abhydrolase domain-containing protein 12.

ABD12_MOUSE
θ value	8.99809 (rank : 153)	NC score	0.011691 (rank : 128)
Query Neighborhood Hits	165	Target Neighborhood Hits	13	Shared Neighborhood Hits	4
SwissProt Accessions	Q99LR1, Q99M06	Gene names	Abhd12
Domain Architecture
Description	Abhydrolase domain-containing protein 12.

ADRM1_MOUSE
θ value	8.99809 (rank : 154)	NC score	0.017168 (rank : 106)
Query Neighborhood Hits	165	Target Neighborhood Hits	84	Shared Neighborhood Hits	9
SwissProt Accessions	Q9JKV1	Gene names	Adrm1, Gp110
Domain Architecture
Description	Adhesion-regulating molecule 1 precursor (110 kDa cell membrane glycoprotein) (Gp110) (ARM-1).

ATS2_MOUSE
θ value	8.99809 (rank : 155)	NC score	0.000975 (rank : 162)
Query Neighborhood Hits	165	Target Neighborhood Hits	179	Shared Neighborhood Hits	6
SwissProt Accessions	Q8C9W3	Gene names	Adamts2
Domain Architecture
Description	ADAMTS-2 precursor (EC 3.4.24.14) (A disintegrin and metalloproteinase with thrombospondin motifs 2) (ADAM-TS 2) (ADAM-TS2) (Procollagen I/II amino propeptide-processing enzyme) (Procollagen I N-proteinase) (PC I-NP) (Procollagen N-endopeptidase) (pNPI).

CAC1G_HUMAN
θ value	8.99809 (rank : 156)	NC score	0.015255 (rank : 112)
Query Neighborhood Hits	165	Target Neighborhood Hits	587	Shared Neighborhood Hits	34
SwissProt Accessions	O43497, O43498, O94770, Q9NYU4, Q9NYU5, Q9NYU6, Q9NYU7, Q9NYU8, Q9NYU9, Q9NYV0, Q9NYV1, Q9UHN9, Q9UHP0, Q9ULU6, Q9UNG7, Q9Y5T2, Q9Y5T3	Gene names	CACNA1G, KIAA1123
Domain Architecture
Description	Voltage-dependent T-type calcium channel subunit alpha-1G (Voltage- gated calcium channel subunit alpha Cav3.1) (Cav3.1c) (NBR13).

FRS3_MOUSE
θ value	8.99809 (rank : 157)	NC score	0.015563 (rank : 111)
Query Neighborhood Hits	165	Target Neighborhood Hits	168	Shared Neighborhood Hits	13
SwissProt Accessions	Q91WJ0	Gene names	Frs3, Frs2b
Domain Architecture	No domain graphic available
Description	Fibroblast growth factor receptor substrate 3 (FGFR substrate 3) (FRS2-beta).

HAIR_HUMAN
θ value	8.99809 (rank : 158)	NC score	0.022464 (rank : 99)
Query Neighborhood Hits	165	Target Neighborhood Hits	172	Shared Neighborhood Hits	13
SwissProt Accessions	O43593, Q96H33, Q9NPE1	Gene names	HR
Domain Architecture
Description	Protein hairless.

IF4G1_MOUSE
θ value	8.99809 (rank : 159)	NC score	0.016664 (rank : 107)
Query Neighborhood Hits	165	Target Neighborhood Hits	534	Shared Neighborhood Hits	20
SwissProt Accessions	Q6NZJ6, Q6NZN8, Q8BW99	Gene names	Eif4g1
Domain Architecture	No domain graphic available
Description	Eukaryotic translation initiation factor 4 gamma 1 (eIF-4-gamma 1) (eIF-4G1) (eIF-4G 1).

ISY1_HUMAN
θ value	8.99809 (rank : 160)	NC score	0.006744 (rank : 148)
Query Neighborhood Hits	165	Target Neighborhood Hits	31	Shared Neighborhood Hits	2
SwissProt Accessions	Q9ULR0, Q96IL2, Q9BT05	Gene names	KIAA1160
Domain Architecture	No domain graphic available
Description	Pre-mRNA-splicing factor ISY1 homolog.

NOTC3_HUMAN
θ value	8.99809 (rank : 161)	NC score	-0.000485 (rank : 166)
Query Neighborhood Hits	165	Target Neighborhood Hits	1062	Shared Neighborhood Hits	21
SwissProt Accessions	Q9UM47, Q9UEB3, Q9UPL3, Q9Y6L8	Gene names	NOTCH3
Domain Architecture
Description	Neurogenic locus notch homolog protein 3 precursor (Notch 3) [Contains: Notch 3 extracellular truncation; Notch 3 intracellular domain].

SOCS7_MOUSE
θ value	8.99809 (rank : 162)	NC score	0.007492 (rank : 146)
Query Neighborhood Hits	165	Target Neighborhood Hits	154	Shared Neighborhood Hits	8
SwissProt Accessions	Q8VHQ2	Gene names	Socs7, Cish7, Nap4
Domain Architecture
Description	Suppressor of cytokine signaling 7 (SOCS-7).

SRRM1_MOUSE
θ value	8.99809 (rank : 163)	NC score	0.023782 (rank : 94)
Query Neighborhood Hits	165	Target Neighborhood Hits	966	Shared Neighborhood Hits	38
SwissProt Accessions	Q52KI8, O70495, Q9CVG5	Gene names	Srrm1, Pop101
Domain Architecture	No domain graphic available
Description	Serine/arginine repetitive matrix protein 1 (Plenty-of-prolines 101).

SRRM2_MOUSE
θ value	8.99809 (rank : 164)	NC score	0.030292 (rank : 88)
Query Neighborhood Hits	165	Target Neighborhood Hits	1470	Shared Neighborhood Hits	49
SwissProt Accessions	Q8BTI8, Q3TBY5, Q569P9, Q80U37, Q8K383	Gene names	Srrm2, Kiaa0324
Domain Architecture	No domain graphic available
Description	Serine/arginine repetitive matrix protein 2.

ZN167_HUMAN
θ value	8.99809 (rank : 165)	NC score	-0.003912 (rank : 172)
Query Neighborhood Hits	165	Target Neighborhood Hits	784	Shared Neighborhood Hits	11
SwissProt Accessions	Q9P0L1, Q6WL09, Q96FQ2	Gene names	ZNF167, ZNF448, ZNF64
Domain Architecture	No domain graphic available
Description	Zinc finger protein 167 (Zinc finger protein 64) (Zinc finger protein 448) (ZFP).

CT152_MOUSE
θ value	θ > 10 (rank : 166)	NC score	0.068160 (rank : 58)
Query Neighborhood Hits	165	Target Neighborhood Hits	38	Shared Neighborhood Hits	25
SwissProt Accessions	Q9D5U8, Q8R083	Gene names
Domain Architecture
Description	Uncharacterized protein C20orf152 homolog.

KAP2_HUMAN
θ value	θ > 10 (rank : 167)	NC score	0.090053 (rank : 53)
Query Neighborhood Hits	165	Target Neighborhood Hits	48	Shared Neighborhood Hits	22
SwissProt Accessions	P13861, Q16823	Gene names	PRKAR2A, PKR2, PRKAR2
Domain Architecture
Description	cAMP-dependent protein kinase type II-alpha regulatory subunit.

KAP2_MOUSE
θ value	θ > 10 (rank : 168)	NC score	0.092205 (rank : 52)
Query Neighborhood Hits	165	Target Neighborhood Hits	44	Shared Neighborhood Hits	22
SwissProt Accessions	P12367	Gene names	Prkar2a
Domain Architecture
Description	cAMP-dependent protein kinase type II-alpha regulatory subunit.

KAP3_HUMAN
θ value	θ > 10 (rank : 169)	NC score	0.089235 (rank : 54)
Query Neighborhood Hits	165	Target Neighborhood Hits	40	Shared Neighborhood Hits	25
SwissProt Accessions	P31323	Gene names	PRKAR2B
Domain Architecture
Description	cAMP-dependent protein kinase type II-beta regulatory subunit.

KAP3_MOUSE
θ value	θ > 10 (rank : 170)	NC score	0.092599 (rank : 51)
Query Neighborhood Hits	165	Target Neighborhood Hits	43	Shared Neighborhood Hits	25
SwissProt Accessions	P31324, Q3UTZ1, Q80ZM4, Q8BRZ7	Gene names	Prkar2b
Domain Architecture	No domain graphic available
Description	cAMP-dependent protein kinase type II-beta regulatory subunit.

KCNK7_HUMAN
θ value	θ > 10 (rank : 171)	NC score	0.053416 (rank : 68)
Query Neighborhood Hits	165	Target Neighborhood Hits	42	Shared Neighborhood Hits	25
SwissProt Accessions	Q9Y2U2, Q9Y2U3, Q9Y2U4	Gene names	KCNK7
Domain Architecture	No domain graphic available
Description	Potassium channel subfamily K member 7.

KCNK7_MOUSE
θ value	θ > 10 (rank : 172)	NC score	0.070677 (rank : 57)
Query Neighborhood Hits	165	Target Neighborhood Hits	53	Shared Neighborhood Hits	31
SwissProt Accessions	Q9Z2T1, Q9QXY0, Q9QYE8, Q9R1V1, Q9R242	Gene names	Kcnk7, Dpkch3, Kcnk6, Kcnk8, Knot1
Domain Architecture	No domain graphic available
Description	Potassium channel subfamily K member 7 (Putative potassium channel DP3) (Double-pore K(+) channel 3) (Neuromuscular two p domain potassium channel).

Hits sorted by NC score

KCNH2_MOUSE
NC score	0.999962 (rank : 1)	θ value	0 (rank : 2)
Query Neighborhood Hits	165	Target Neighborhood Hits	165	Shared Neighborhood Hits	165
SwissProt Accessions	O35219, O35220, O35221, O35989	Gene names	Kcnh2, Erg, Merg1
Domain Architecture
Description	Potassium voltage-gated channel subfamily H member 2 (Voltage-gated potassium channel subunit Kv11.1) (Ether-a-go-go-related gene potassium channel 1) (ERG1) (MERG) (Merg1) (Ether-a-go-go-related protein 1) (Eag-related protein 1).

KCNH2_HUMAN
NC score	0.995949 (rank : 2)	θ value	0 (rank : 1)
Query Neighborhood Hits	165	Target Neighborhood Hits	158	Shared Neighborhood Hits	110
SwissProt Accessions	Q12809, O75418, O75680, Q9BT72, Q9BUT7, Q9H3P0	Gene names	KCNH2, ERG, ERG1, HERG, HERG1
Domain Architecture
Description	Potassium voltage-gated channel subfamily H member 2 (Voltage-gated potassium channel subunit Kv11.1) (Ether-a-go-go-related gene potassium channel 1) (H-ERG) (Erg1) (Ether-a-go-go-related protein 1) (Eag-related protein 1) (eag homolog).

KCNH7_MOUSE
NC score	0.989898 (rank : 3)	θ value	0 (rank : 5)
Query Neighborhood Hits	165	Target Neighborhood Hits	98	Shared Neighborhood Hits	72
SwissProt Accessions	Q9ER47	Gene names	Kcnh7, Erg3
Domain Architecture
Description	Potassium voltage-gated channel subfamily H member 7 (Voltage-gated potassium channel subunit Kv11.3) (Ether-a-go-go-related gene potassium channel 3) (Ether-a-go-go-related protein 3) (Eag-related protein 3).

KCNH7_HUMAN
NC score	0.989176 (rank : 4)	θ value	0 (rank : 4)
Query Neighborhood Hits	165	Target Neighborhood Hits	107	Shared Neighborhood Hits	72
SwissProt Accessions	Q9NS40	Gene names	KCNH7, ERG3
Domain Architecture
Description	Potassium voltage-gated channel subfamily H member 7 (Voltage-gated potassium channel subunit Kv11.3) (Ether-a-go-go-related gene potassium channel 3) (HERG-3) (Ether-a-go-go-related protein 3) (Eag- related protein 3).

KCNH6_HUMAN
NC score	0.979441 (rank : 5)	θ value	0 (rank : 3)
Query Neighborhood Hits	165	Target Neighborhood Hits	222	Shared Neighborhood Hits	77
SwissProt Accessions	Q9H252, Q9BRD7	Gene names	KCNH6, ERG2, HERG2
Domain Architecture
Description	Potassium voltage-gated channel subfamily H member 6 (Voltage-gated potassium channel subunit Kv11.2) (Ether-a-go-go-related gene potassium channel 2) (Ether-a-go-go-related protein 2) (Eag-related protein 2).

KCNH8_HUMAN
NC score	0.960275 (rank : 6)	θ value	6.21357e-126 (rank : 6)
Query Neighborhood Hits	165	Target Neighborhood Hits	104	Shared Neighborhood Hits	58
SwissProt Accessions	Q96L42	Gene names	KCNH8
Domain Architecture
Description	Potassium voltage-gated channel subfamily H member 8 (Voltage-gated potassium channel subunit Kv12.1) (Ether-a-go-go-like potassium channel 3) (ELK channel 3) (ELK3) (ELK1) (hElk1).

KCNH4_HUMAN
NC score	0.957133 (rank : 7)	θ value	4.60808e-121 (rank : 11)
Query Neighborhood Hits	165	Target Neighborhood Hits	177	Shared Neighborhood Hits	60
SwissProt Accessions	Q9UQ05	Gene names	KCNH4
Domain Architecture
Description	Potassium voltage-gated channel subfamily H member 4 (Voltage-gated potassium channel subunit Kv12.3) (Ether-a-go-go-like potassium channel 1) (ELK channel 1) (ELK1) (Brain-specific eag-like channel 2) (BEC2).

KCNH5_MOUSE
NC score	0.954017 (rank : 8)	θ value	7.10925e-122 (rank : 8)
Query Neighborhood Hits	165	Target Neighborhood Hits	102	Shared Neighborhood Hits	57
SwissProt Accessions	Q920E3, Q8C035	Gene names	Kcnh5, Eag2
Domain Architecture	No domain graphic available
Description	Potassium voltage-gated channel subfamily H member 5 (Voltage-gated potassium channel subunit Kv10.2) (Ether-a-go-go potassium channel 2) (Eag2).

KCNH5_HUMAN
NC score	0.954007 (rank : 9)	θ value	3.19119e-122 (rank : 7)
Query Neighborhood Hits	165	Target Neighborhood Hits	99	Shared Neighborhood Hits	57
SwissProt Accessions	Q8NCM2	Gene names	KCNH5, EAG2
Domain Architecture
Description	Potassium voltage-gated channel subfamily H member 5 (Voltage-gated potassium channel subunit Kv10.2) (Ether-a-go-go potassium channel 2) (hEAG2).

KCNH1_MOUSE
NC score	0.953382 (rank : 10)	θ value	4.60808e-121 (rank : 10)
Query Neighborhood Hits	165	Target Neighborhood Hits	94	Shared Neighborhood Hits	58
SwissProt Accessions	Q60603	Gene names	Kcnh1, Eag
Domain Architecture
Description	Potassium voltage-gated channel subfamily H member 1 (Voltage-gated potassium channel subunit Kv10.1) (Ether-a-go-go potassium channel 1) (EAG1) (m-eag).

KCNH1_HUMAN
NC score	0.953264 (rank : 11)	θ value	3.52827e-121 (rank : 9)
Query Neighborhood Hits	165	Target Neighborhood Hits	98	Shared Neighborhood Hits	58
SwissProt Accessions	O95259, O76035	Gene names	KCNH1, EAG, EAG1
Domain Architecture
Description	Potassium voltage-gated channel subfamily H member 1 (Voltage-gated potassium channel subunit Kv10.1) (Ether-a-go-go potassium channel 1) (hEAG1) (h-eag).

KCNH3_HUMAN
NC score	0.951699 (rank : 12)	θ value	1.02895e-112 (rank : 12)
Query Neighborhood Hits	165	Target Neighborhood Hits	148	Shared Neighborhood Hits	62
SwissProt Accessions	Q9ULD8, Q9UQ06	Gene names	KCNH3, KIAA1282
Domain Architecture
Description	Potassium voltage-gated channel subfamily H member 3 (Voltage-gated potassium channel subunit Kv12.2) (Ether-a-go-go-like potassium channel 2) (ELK channel 2) (ELK2) (Brain-specific eag-like channel 1) (BEC1).

KCNH3_MOUSE
NC score	0.951348 (rank : 13)	θ value	1.75513e-112 (rank : 13)
Query Neighborhood Hits	165	Target Neighborhood Hits	133	Shared Neighborhood Hits	60
SwissProt Accessions	Q9WVJ0	Gene names	Kcnh3, Elk2
Domain Architecture
Description	Potassium voltage-gated channel subfamily H member 3 (Voltage-gated potassium channel subunit Kv12.2) (Ether-a-go-go-like potassium channel 2) (ELK channel 2) (mElk2).

CNGA2_MOUSE
NC score	0.822740 (rank : 14)	θ value	3.86705e-35 (rank : 23)
Query Neighborhood Hits	165	Target Neighborhood Hits	86	Shared Neighborhood Hits	42
SwissProt Accessions	Q62398	Gene names	Cnga2, Cncg2, Cncg4
Domain Architecture
Description	Cyclic nucleotide-gated olfactory channel (Cyclic nucleotide-gated cation channel 2) (CNG channel 2) (CNG-2) (CNG2).

CNGA1_HUMAN
NC score	0.811951 (rank : 15)	θ value	5.584e-34 (rank : 25)
Query Neighborhood Hits	165	Target Neighborhood Hits	149	Shared Neighborhood Hits	38
SwissProt Accessions	P29973, Q16279, Q16485	Gene names	CNGA1, CNCG, CNCG1
Domain Architecture
Description	cGMP-gated cation channel alpha 1 (CNG channel alpha 1) (CNG-1) (CNG1) (Cyclic nucleotide-gated channel alpha 1) (Cyclic nucleotide-gated channel, photoreceptor) (Cyclic nucleotide-gated cation channel 1) (Rod photoreceptor cGMP-gated channel subunit alpha).

CNGA3_MOUSE
NC score	0.811639 (rank : 16)	θ value	1.12514e-34 (rank : 24)
Query Neighborhood Hits	165	Target Neighborhood Hits	84	Shared Neighborhood Hits	41
SwissProt Accessions	Q9JJZ8, Q9WV01	Gene names	Cnga3, Cng3
Domain Architecture
Description	Cyclic nucleotide-gated cation channel alpha 3 (CNG channel alpha 3) (CNG-3) (CNG3) (Cyclic nucleotide-gated channel alpha 3) (Cone photoreceptor cGMP-gated channel subunit alpha).

CNGA3_HUMAN
NC score	0.808631 (rank : 17)	θ value	2.67802e-36 (rank : 22)
Query Neighborhood Hits	165	Target Neighborhood Hits	125	Shared Neighborhood Hits	39
SwissProt Accessions	Q16281, Q9UP64	Gene names	CNGA3, CNCG3
Domain Architecture
Description	Cyclic nucleotide-gated cation channel alpha 3 (CNG channel alpha 3) (CNG-3) (CNG3) (Cyclic nucleotide-gated channel alpha 3) (Cone photoreceptor cGMP-gated channel subunit alpha).

HCN1_HUMAN
NC score	0.808160 (rank : 18)	θ value	2.19075e-38 (rank : 19)
Query Neighborhood Hits	165	Target Neighborhood Hits	120	Shared Neighborhood Hits	41
SwissProt Accessions	O60741	Gene names	HCN1, BCNG1
Domain Architecture
Description	Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1 (Brain cyclic nucleotide-gated channel 1) (BCNG-1).

CNGA1_MOUSE
NC score	0.806974 (rank : 19)	θ value	2.12192e-33 (rank : 26)
Query Neighborhood Hits	165	Target Neighborhood Hits	198	Shared Neighborhood Hits	40
SwissProt Accessions	P29974, Q60776	Gene names	Cnga1, Cncg, Cncg1
Domain Architecture
Description	cGMP-gated cation channel alpha 1 (CNG channel alpha 1) (CNG-1) (CNG1) (Cyclic nucleotide-gated channel alpha 1) (Cyclic nucleotide-gated channel, photoreceptor) (Cyclic nucleotide-gated cation channel 1) (Rod photoreceptor cGMP-gated channel subunit alpha).

HCN3_MOUSE
NC score	0.805018 (rank : 20)	θ value	4.88048e-38 (rank : 21)
Query Neighborhood Hits	165	Target Neighborhood Hits	112	Shared Neighborhood Hits	38
SwissProt Accessions	O88705	Gene names	Hcn3, Hac3
Domain Architecture
Description	Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 3 (Hyperpolarization-activated cation channel 3) (HAC-3).

HCN3_HUMAN
NC score	0.804992 (rank : 21)	θ value	1.28434e-38 (rank : 17)
Query Neighborhood Hits	165	Target Neighborhood Hits	99	Shared Neighborhood Hits	38
SwissProt Accessions	Q9P1Z3, Q4VX12, Q8N6W6, Q9BWQ2	Gene names	HCN3, KIAA1535
Domain Architecture
Description	Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 3.

HCN1_MOUSE
NC score	0.804661 (rank : 22)	θ value	2.19075e-38 (rank : 20)
Query Neighborhood Hits	165	Target Neighborhood Hits	172	Shared Neighborhood Hits	44
SwissProt Accessions	O88704, O54899, Q9D613	Gene names	Hcn1, Bcng1, Hac2
Domain Architecture
Description	Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1 (Brain cyclic nucleotide-gated channel 1) (BCNG-1) (Hyperpolarization-activated cation channel 2) (HAC-2).

HCN2_MOUSE
NC score	0.795086 (rank : 23)	θ value	5.76516e-39 (rank : 16)
Query Neighborhood Hits	165	Target Neighborhood Hits	278	Shared Neighborhood Hits	62
SwissProt Accessions	O88703, O70506	Gene names	Hcn2, Bcng2, Hac1
Domain Architecture
Description	Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 (Brain cyclic nucleotide-gated channel 2) (BCNG-2) (Hyperpolarization-activated cation channel 1) (HAC-1).

HCN4_HUMAN
NC score	0.792674 (rank : 24)	θ value	1.51715e-39 (rank : 14)
Query Neighborhood Hits	165	Target Neighborhood Hits	303	Shared Neighborhood Hits	58
SwissProt Accessions	Q9Y3Q4, Q9UMQ7	Gene names	HCN4
Domain Architecture
Description	Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4.

HCN4_MOUSE
NC score	0.790278 (rank : 25)	θ value	1.6774e-38 (rank : 18)
Query Neighborhood Hits	165	Target Neighborhood Hits	284	Shared Neighborhood Hits	60
SwissProt Accessions	O70507	Gene names	Hcn4, Bcng3
Domain Architecture
Description	Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 (Brain cyclic nucleotide-gated channel 3) (BCNG-3).

HCN2_HUMAN
NC score	0.787630 (rank : 26)	θ value	5.76516e-39 (rank : 15)
Query Neighborhood Hits	165	Target Neighborhood Hits	369	Shared Neighborhood Hits	63
SwissProt Accessions	Q9UL51, O60742, O60743, O75267, Q9UBS2	Gene names	HCN2, BCNG2
Domain Architecture
Description	Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 (Brain cyclic nucleotide-gated channel 2) (BCNG-2).

CNGB3_MOUSE
NC score	0.754511 (rank : 27)	θ value	9.87957e-23 (rank : 27)
Query Neighborhood Hits	165	Target Neighborhood Hits	74	Shared Neighborhood Hits	39
SwissProt Accessions	Q9JJZ9	Gene names	Cngb3, Cng6
Domain Architecture
Description	Cyclic nucleotide-gated cation channel beta 3 (CNG channel beta 3) (Cyclic nucleotide-gated channel beta 3) (Cone photoreceptor cGMP- gated channel subunit beta) (Cyclic nucleotide-gated cation channel modulatory subunit) (Cyclic nucleotide-gated channel subunit CNG6).

CNGB3_HUMAN
NC score	0.739150 (rank : 28)	θ value	1.74391e-19 (rank : 28)
Query Neighborhood Hits	165	Target Neighborhood Hits	206	Shared Neighborhood Hits	43
SwissProt Accessions	Q9NQW8, Q9NRE9	Gene names	CNGB3
Domain Architecture
Description	Cyclic nucleotide-gated cation channel beta 3 (CNG channel beta 3) (Cyclic nucleotide-gated channel beta 3) (Cone photoreceptor cGMP- gated channel subunit beta) (Cyclic nucleotide-gated cation channel modulatory subunit).

CNGB1_HUMAN
NC score	0.731567 (rank : 29)	θ value	5.60996e-18 (rank : 29)
Query Neighborhood Hits	165	Target Neighborhood Hits	222	Shared Neighborhood Hits	41
SwissProt Accessions	Q14028, Q14029	Gene names	CNGB1, CNCG4
Domain Architecture
Description	Cyclic nucleotide-gated cation channel 4 (CNG channel 4) (CNG-4) (CNG4) (Cyclic nucleotide-gated cation channel modulatory subunit).

KCNKH_HUMAN
NC score	0.246931 (rank : 30)	θ value	0.00298849 (rank : 30)
Query Neighborhood Hits	165	Target Neighborhood Hits	89	Shared Neighborhood Hits	46
SwissProt Accessions	Q96T54, Q5TCF4, Q8TAW4, Q9BXD1, Q9H592	Gene names	KCNK17, TALK2, TASK4
Domain Architecture
Description	Potassium channel subfamily K member 17 (TWIK-related alkaline pH- activated K(+) channel 2) (2P domain potassium channel Talk-2) (TWIK- related acid-sensitive K(+) channel 4) (TASK-4).

KCNKF_HUMAN
NC score	0.188300 (rank : 31)	θ value	0.0113563 (rank : 33)
Query Neighborhood Hits	165	Target Neighborhood Hits	87	Shared Neighborhood Hits	44
SwissProt Accessions	Q9H427, Q9HBC8	Gene names	KCNK15, TASK5
Domain Architecture
Description	Potassium channel subfamily K member 15 (Acid-sensitive potassium channel protein TASK-5) (TWIK-related acid-sensitive K(+) channel 5) (Two pore potassium channel KT3.3).

KCNK2_HUMAN
NC score	0.183939 (rank : 32)	θ value	0.0113563 (rank : 31)
Query Neighborhood Hits	165	Target Neighborhood Hits	86	Shared Neighborhood Hits	46
SwissProt Accessions	O95069, Q9UNE3	Gene names	KCNK2, TREK, TREK1
Domain Architecture	No domain graphic available
Description	Potassium channel subfamily K member 2 (Outward rectifying potassium channel protein TREK-1) (TREK-1 K(+) channel subunit) (Two-pore potassium channel TPKC1).

KCNK2_MOUSE
NC score	0.183304 (rank : 33)	θ value	0.0113563 (rank : 32)
Query Neighborhood Hits	165	Target Neighborhood Hits	88	Shared Neighborhood Hits	46
SwissProt Accessions	P97438	Gene names	Kcnk2
Domain Architecture	No domain graphic available
Description	Potassium channel subfamily K member 2 (Outward rectifying potassium channel protein TREK-1) (Two-pore potassium channel TPKC1) (TREK-1 K(+) channel subunit).

KCNK3_HUMAN
NC score	0.175485 (rank : 34)	θ value	0.0961366 (rank : 39)
Query Neighborhood Hits	165	Target Neighborhood Hits	88	Shared Neighborhood Hits	46
SwissProt Accessions	O14649	Gene names	KCNK3, TASK, TASK1
Domain Architecture
Description	Potassium channel subfamily K member 3 (Acid-sensitive potassium channel protein TASK-1) (TWIK-related acid-sensitive K(+) channel 1) (Two pore potassium channel KT3.1).

KCNKA_HUMAN
NC score	0.174126 (rank : 35)	θ value	0.0736092 (rank : 37)
Query Neighborhood Hits	165	Target Neighborhood Hits	111	Shared Neighborhood Hits	46
SwissProt Accessions	P57789, Q8TDK7, Q8TDK8, Q9HB59	Gene names	KCNK10, TREK2
Domain Architecture
Description	Potassium channel subfamily K member 10 (Outward rectifying potassium channel protein TREK-2) (TREK-2 K(+) channel subunit).

KCNK6_HUMAN
NC score	0.173560 (rank : 36)	θ value	0.0961366 (rank : 40)
Query Neighborhood Hits	165	Target Neighborhood Hits	79	Shared Neighborhood Hits	44
SwissProt Accessions	Q9Y257, Q9HB47	Gene names	KCNK6, TOSS, TWIK2
Domain Architecture
Description	Potassium channel subfamily K member 6 (Inward rectifying potassium channel protein TWIK-2) (TWIK-originated similarity sequence).

KCNK3_MOUSE
NC score	0.171821 (rank : 37)	θ value	0.163984 (rank : 43)
Query Neighborhood Hits	165	Target Neighborhood Hits	93	Shared Neighborhood Hits	46
SwissProt Accessions	O35111, O35163	Gene names	Kcnk3, Ctbak, Task, Task1
Domain Architecture
Description	Potassium channel subfamily K member 3 (Acid-sensitive potassium channel protein TASK-1) (TWIK-related acid-sensitive K(+) channel 1) (Cardiac two-pore background K(+) channel) (cTBAK-1) (Two pore potassium channel KT3.1).

KCNK4_HUMAN
NC score	0.163263 (rank : 38)	θ value	0.47712 (rank : 56)
Query Neighborhood Hits	165	Target Neighborhood Hits	109	Shared Neighborhood Hits	50
SwissProt Accessions	Q9NYG8, Q96T94	Gene names	KCNK4, TRAAK
Domain Architecture
Description	Potassium channel subfamily K member 4 (TWIK-related arachidonic acid- stimulated potassium channel protein) (TRAAK) (Two pore K(+) channel KT4.1).

KCNKG_HUMAN
NC score	0.160547 (rank : 39)	θ value	1.38821 (rank : 72)
Query Neighborhood Hits	165	Target Neighborhood Hits	90	Shared Neighborhood Hits	44
SwissProt Accessions	Q96T55, Q5TCF3, Q9H591	Gene names	KCNK16, TALK1
Domain Architecture	No domain graphic available
Description	Potassium channel subfamily K member 16 (TWIK-related alkaline pH- activated K(+) channel 1) (2P domain potassium channel Talk-1).

KAP0_HUMAN
NC score	0.156057 (rank : 40)	θ value	1.06291 (rank : 70)
Query Neighborhood Hits	165	Target Neighborhood Hits	52	Shared Neighborhood Hits	32
SwissProt Accessions	P10644, Q567S7	Gene names	PRKAR1A, PKR1, PRKAR1
Domain Architecture
Description	cAMP-dependent protein kinase type I-alpha regulatory subunit (Tissue- specific extinguisher 1) (TSE1).

KCNK4_MOUSE
NC score	0.152683 (rank : 41)	θ value	0.47712 (rank : 57)
Query Neighborhood Hits	165	Target Neighborhood Hits	118	Shared Neighborhood Hits	49
SwissProt Accessions	O88454	Gene names	Kcnk4, Traak
Domain Architecture	No domain graphic available
Description	Potassium channel subfamily K member 4 (TWIK-related arachidonic acid- stimulated potassium channel protein) (TRAAK).

KCNK9_MOUSE
NC score	0.146938 (rank : 42)	θ value	0.813845 (rank : 66)
Query Neighborhood Hits	165	Target Neighborhood Hits	86	Shared Neighborhood Hits	44
SwissProt Accessions	Q3LS21	Gene names	Kcnk9, Task3
Domain Architecture	No domain graphic available
Description	Potassium channel subfamily K member 9 (Acid-sensitive potassium channel protein TASK-3) (TWIK-related acid-sensitive K(+) channel 3).

KCNK9_HUMAN
NC score	0.146796 (rank : 43)	θ value	0.813845 (rank : 65)
Query Neighborhood Hits	165	Target Neighborhood Hits	86	Shared Neighborhood Hits	44
SwissProt Accessions	Q9NPC2, Q2M290, Q540F2	Gene names	KCNK9, TASK3
Domain Architecture
Description	Potassium channel subfamily K member 9 (Acid-sensitive potassium channel protein TASK-3) (TWIK-related acid-sensitive K(+) channel 3) (Two pore potassium channel KT3.2).

KAP0_MOUSE
NC score	0.144674 (rank : 44)	θ value	0.62314 (rank : 59)
Query Neighborhood Hits	165	Target Neighborhood Hits	48	Shared Neighborhood Hits	32
SwissProt Accessions	Q9DBC7, Q3UKU7, Q9JHR5, Q9JHR6	Gene names	Prkar1a
Domain Architecture	No domain graphic available
Description	cAMP-dependent protein kinase type I-alpha regulatory subunit.

KAP1_HUMAN
NC score	0.131616 (rank : 45)	θ value	2.36792 (rank : 82)
Query Neighborhood Hits	165	Target Neighborhood Hits	58	Shared Neighborhood Hits	30
SwissProt Accessions	P31321	Gene names	PRKAR1B
Domain Architecture
Description	cAMP-dependent protein kinase type I-beta regulatory subunit.

KAP1_MOUSE
NC score	0.129316 (rank : 46)	θ value	2.36792 (rank : 83)
Query Neighborhood Hits	165	Target Neighborhood Hits	49	Shared Neighborhood Hits	30
SwissProt Accessions	P12849	Gene names	Prkar1b
Domain Architecture
Description	cAMP-dependent protein kinase type I-beta regulatory subunit.

KCNK1_HUMAN
NC score	0.124690 (rank : 47)	θ value	1.81305 (rank : 77)
Query Neighborhood Hits	165	Target Neighborhood Hits	68	Shared Neighborhood Hits	43
SwissProt Accessions	O00180, Q13307	Gene names	KCNK1, HOHO1, KCNO1, TWIK1
Domain Architecture	No domain graphic available
Description	Potassium channel subfamily K member 1 (Inward rectifying potassium channel protein TWIK-1) (Potassium channel KCNO1).

KCNK5_HUMAN
NC score	0.123696 (rank : 48)	θ value	2.36792 (rank : 86)
Query Neighborhood Hits	165	Target Neighborhood Hits	102	Shared Neighborhood Hits	48
SwissProt Accessions	O95279	Gene names	KCNK5, TASK2
Domain Architecture
Description	Potassium channel subfamily K member 5 (Acid-sensitive potassium channel protein TASK-2) (TWIK-related acid-sensitive K(+) channel 2).

KCNK1_MOUSE
NC score	0.120023 (rank : 49)	θ value	3.0926 (rank : 96)
Query Neighborhood Hits	165	Target Neighborhood Hits	70	Shared Neighborhood Hits	41
SwissProt Accessions	O08581	Gene names	Kcnk1
Domain Architecture
Description	Potassium channel subfamily K member 1 (Inward rectifying potassium channel protein TWIK-1).

KCNKD_MOUSE
NC score	0.101106 (rank : 50)	θ value	0.813845 (rank : 67)
Query Neighborhood Hits	165	Target Neighborhood Hits	51	Shared Neighborhood Hits	33
SwissProt Accessions	Q8R1P5	Gene names	Kcnk13
Domain Architecture
Description	Potassium channel subfamily K member 13 (Tandem pore domain halothane- inhibited potassium channel 1) (THIK-1).

KAP3_MOUSE
NC score	0.092599 (rank : 51)	θ value	θ > 10 (rank : 170)
Query Neighborhood Hits	165	Target Neighborhood Hits	43	Shared Neighborhood Hits	25
SwissProt Accessions	P31324, Q3UTZ1, Q80ZM4, Q8BRZ7	Gene names	Prkar2b
Domain Architecture	No domain graphic available
Description	cAMP-dependent protein kinase type II-beta regulatory subunit.

KAP2_MOUSE
NC score	0.092205 (rank : 52)	θ value	θ > 10 (rank : 168)
Query Neighborhood Hits	165	Target Neighborhood Hits	44	Shared Neighborhood Hits	22
SwissProt Accessions	P12367	Gene names	Prkar2a
Domain Architecture
Description	cAMP-dependent protein kinase type II-alpha regulatory subunit.

KAP2_HUMAN
NC score	0.090053 (rank : 53)	θ value	θ > 10 (rank : 167)
Query Neighborhood Hits	165	Target Neighborhood Hits	48	Shared Neighborhood Hits	22
SwissProt Accessions	P13861, Q16823	Gene names	PRKAR2A, PKR2, PRKAR2
Domain Architecture
Description	cAMP-dependent protein kinase type II-alpha regulatory subunit.

KAP3_HUMAN
NC score	0.089235 (rank : 54)	θ value	θ > 10 (rank : 169)
Query Neighborhood Hits	165	Target Neighborhood Hits	40	Shared Neighborhood Hits	25
SwissProt Accessions	P31323	Gene names	PRKAR2B
Domain Architecture
Description	cAMP-dependent protein kinase type II-beta regulatory subunit.

KCNKD_HUMAN
NC score	0.080263 (rank : 55)	θ value	5.27518 (rank : 121)
Query Neighborhood Hits	165	Target Neighborhood Hits	58	Shared Neighborhood Hits	33
SwissProt Accessions	Q9HB14, Q96E79	Gene names	KCNK13
Domain Architecture
Description	Potassium channel subfamily K member 13 (Tandem pore domain halothane- inhibited potassium channel 1) (THIK-1).

KCNKC_HUMAN
NC score	0.078216 (rank : 56)	θ value	4.03905 (rank : 113)
Query Neighborhood Hits	165	Target Neighborhood Hits	51	Shared Neighborhood Hits	32
SwissProt Accessions	Q9HB15	Gene names	KCNK12
Domain Architecture	No domain graphic available
Description	Potassium channel subfamily K member 12 (Tandem pore domain halothane- inhibited potassium channel 2) (THIK-2).

KCNK7_MOUSE
NC score	0.070677 (rank : 57)	θ value	θ > 10 (rank : 172)
Query Neighborhood Hits	165	Target Neighborhood Hits	53	Shared Neighborhood Hits	31
SwissProt Accessions	Q9Z2T1, Q9QXY0, Q9QYE8, Q9R1V1, Q9R242	Gene names	Kcnk7, Dpkch3, Kcnk6, Kcnk8, Knot1
Domain Architecture	No domain graphic available
Description	Potassium channel subfamily K member 7 (Putative potassium channel DP3) (Double-pore K(+) channel 3) (Neuromuscular two p domain potassium channel).

CT152_MOUSE
NC score	0.068160 (rank : 58)	θ value	θ > 10 (rank : 166)
Query Neighborhood Hits	165	Target Neighborhood Hits	38	Shared Neighborhood Hits	25
SwissProt Accessions	Q9D5U8, Q8R083	Gene names
Domain Architecture
Description	Uncharacterized protein C20orf152 homolog.

KCND1_MOUSE
NC score	0.066370 (rank : 59)	θ value	0.0961366 (rank : 38)
Query Neighborhood Hits	165	Target Neighborhood Hits	165	Shared Neighborhood Hits	48
SwissProt Accessions	Q03719, Q8CC68	Gene names	Kcnd1
Domain Architecture
Description	Potassium voltage-gated channel subfamily D member 1 (Voltage-gated potassium channel subunit Kv4.1) (mShal).

KCND1_HUMAN
NC score	0.060414 (rank : 60)	θ value	0.47712 (rank : 55)
Query Neighborhood Hits	165	Target Neighborhood Hits	160	Shared Neighborhood Hits	45
SwissProt Accessions	Q9NSA2, O75671	Gene names	KCND1
Domain Architecture
Description	Potassium voltage-gated channel subfamily D member 1 (Voltage-gated potassium channel subunit Kv4.1).

KCMA1_MOUSE
NC score	0.059909 (rank : 61)	θ value	3.0926 (rank : 95)
Query Neighborhood Hits	165	Target Neighborhood Hits	94	Shared Neighborhood Hits	37
SwissProt Accessions	Q08460, Q64703, Q8VHF1, Q9R196	Gene names	Kcnma1, Kcnma
Domain Architecture
Description	Calcium-activated potassium channel subunit alpha 1 (Calcium-activated potassium channel, subfamily M subunit alpha 1) (Maxi K channel) (MaxiK) (BK channel) (K(VCA)alpha) (BKCA alpha) (KCa1.1) (Slowpoke homolog) (Slo homolog) (Slo-alpha) (Slo1) (mSlo) (mSlo1).

KCMA1_HUMAN
NC score	0.059802 (rank : 62)	θ value	3.0926 (rank : 94)
Query Neighborhood Hits	165	Target Neighborhood Hits	96	Shared Neighborhood Hits	37
SwissProt Accessions	Q12791, Q12886, Q12917, Q12921, Q12960, Q13150, Q96LG8, Q9UBB0, Q9UQK6	Gene names	KCNMA1, KCNMA
Domain Architecture
Description	Calcium-activated potassium channel subunit alpha 1 (Calcium-activated potassium channel, subfamily M subunit alpha 1) (Maxi K channel) (MaxiK) (BK channel) (K(VCA)alpha) (BKCA alpha) (KCa1.1) (Slowpoke homolog) (Slo homolog) (Slo-alpha) (Slo1) (hSlo).

KCND2_HUMAN
NC score	0.058868 (rank : 63)	θ value	0.365318 (rank : 50)
Query Neighborhood Hits	165	Target Neighborhood Hits	154	Shared Neighborhood Hits	45
SwissProt Accessions	Q9NZV8, O95012, O95021, Q9UBY7, Q9UN98, Q9UNH9	Gene names	KCND2, KIAA1044
Domain Architecture
Description	Potassium voltage-gated channel subfamily D member 2 (Voltage-gated potassium channel subunit Kv4.2).

KCND2_MOUSE
NC score	0.058857 (rank : 64)	θ value	0.365318 (rank : 51)
Query Neighborhood Hits	165	Target Neighborhood Hits	156	Shared Neighborhood Hits	45
SwissProt Accessions	Q9Z0V2, Q8BSK3, Q8CHB7, Q9JJ60	Gene names	Kcnd2, Kiaa1044
Domain Architecture
Description	Potassium voltage-gated channel subfamily D member 2 (Voltage-gated potassium channel subunit Kv4.2).

KCND3_MOUSE
NC score	0.055593 (rank : 65)	θ value	2.36792 (rank : 85)
Query Neighborhood Hits	165	Target Neighborhood Hits	162	Shared Neighborhood Hits	44
SwissProt Accessions	Q9Z0V1, Q8CC44, Q9Z0V0	Gene names	Kcnd3
Domain Architecture
Description	Potassium voltage-gated channel subfamily D member 3 (Voltage-gated potassium channel subunit Kv4.3).

KCND3_HUMAN
NC score	0.055580 (rank : 66)	θ value	2.36792 (rank : 84)
Query Neighborhood Hits	165	Target Neighborhood Hits	162	Shared Neighborhood Hits	44
SwissProt Accessions	Q9UK17, O60576, O60577, Q5T0M0, Q9UH85, Q9UH86, Q9UK16	Gene names	KCND3
Domain Architecture
Description	Potassium voltage-gated channel subfamily D member 3 (Voltage-gated potassium channel subunit Kv4.3).

KCNQ3_MOUSE
NC score	0.055091 (rank : 67)	θ value	4.03905 (rank : 114)
Query Neighborhood Hits	165	Target Neighborhood Hits	105	Shared Neighborhood Hits	42
SwissProt Accessions	Q8K3F6	Gene names	Kcnq3
Domain Architecture	No domain graphic available
Description	Potassium voltage-gated channel subfamily KQT member 3 (Voltage-gated potassium channel subunit Kv7.3) (Potassium channel subunit alpha KvLQT3) (KQT-like 3).

KCNK7_HUMAN
NC score	0.053416 (rank : 68)	θ value	θ > 10 (rank : 171)
Query Neighborhood Hits	165	Target Neighborhood Hits	42	Shared Neighborhood Hits	25
SwissProt Accessions	Q9Y2U2, Q9Y2U3, Q9Y2U4	Gene names	KCNK7
Domain Architecture	No domain graphic available
Description	Potassium channel subfamily K member 7.

KCNQ3_HUMAN
NC score	0.052958 (rank : 69)	θ value	6.88961 (rank : 140)
Query Neighborhood Hits	165	Target Neighborhood Hits	114	Shared Neighborhood Hits	42
SwissProt Accessions	O43525	Gene names	KCNQ3
Domain Architecture
Description	Potassium voltage-gated channel subfamily KQT member 3 (Voltage-gated potassium channel subunit Kv7.3) (Potassium channel subunit alpha KvLQT3) (KQT-like 3).

RPGF4_MOUSE
NC score	0.043636 (rank : 70)	θ value	4.03905 (rank : 116)
Query Neighborhood Hits	165	Target Neighborhood Hits	80	Shared Neighborhood Hits	20
SwissProt Accessions	Q9EQZ6, Q8VIP9, Q9CW52, Q9Z1P0	Gene names	Rapgef4, Cgef2, Epac2
Domain Architecture
Description	Rap guanine nucleotide exchange factor 4 (cAMP-regulated guanine nucleotide exchange factor II) (cAMP-GEFII) (Exchange factor directly activated by cAMP 2) (Epac 2) (cAMP-dependent Rap1 guanine-nucleotide exchange factor).

KGP1B_HUMAN
NC score	0.043452 (rank : 71)	θ value	0.279714 (rank : 47)
Query Neighborhood Hits	165	Target Neighborhood Hits	921	Shared Neighborhood Hits	40
SwissProt Accessions	P14619	Gene names	PRKG1, PRKG1B, PRKGR1B
Domain Architecture
Description	cGMP-dependent protein kinase 1, beta isozyme (EC 2.7.11.12) (cGK 1 beta) (cGKI-beta).

KGP1A_HUMAN
NC score	0.043407 (rank : 72)	θ value	0.279714 (rank : 46)
Query Neighborhood Hits	165	Target Neighborhood Hits	901	Shared Neighborhood Hits	40
SwissProt Accessions	Q13976	Gene names	PRKG1, PRKGR1A
Domain Architecture
Description	cGMP-dependent protein kinase 1, alpha isozyme (EC 2.7.11.12) (CGK 1 alpha) (cGKI-alpha).

KGP1B_MOUSE
NC score	0.042998 (rank : 73)	θ value	0.62314 (rank : 60)
Query Neighborhood Hits	165	Target Neighborhood Hits	922	Shared Neighborhood Hits	40
SwissProt Accessions	Q9Z0Z0	Gene names	Prkg1, Prkg1b, Prkgr1b
Domain Architecture
Description	cGMP-dependent protein kinase 1, beta isozyme (EC 2.7.11.12) (cGK 1 beta) (cGKI-beta).

NRX2B_HUMAN
NC score	0.040775 (rank : 74)	θ value	0.365318 (rank : 53)
Query Neighborhood Hits	165	Target Neighborhood Hits	481	Shared Neighborhood Hits	17
SwissProt Accessions	P58401	Gene names	NRXN2
Domain Architecture	No domain graphic available
Description	Neurexin-2-beta precursor (Neurexin II-beta).

KCNQ2_HUMAN
NC score	0.040728 (rank : 75)	θ value	3.0926 (rank : 97)
Query Neighborhood Hits	165	Target Neighborhood Hits	114	Shared Neighborhood Hits	42
SwissProt Accessions	O43526, O43796, O75580, O95845, Q5VYT8, Q96J59, Q99454	Gene names	KCNQ2
Domain Architecture
Description	Potassium voltage-gated channel subfamily KQT member 2 (Voltage-gated potassium channel subunit Kv7.2) (Neuroblastoma-specific potassium channel subunit alpha KvLQT2) (KQT-like 2).

PSL1_HUMAN
NC score	0.040508 (rank : 76)	θ value	1.06291 (rank : 71)
Query Neighborhood Hits	165	Target Neighborhood Hits	650	Shared Neighborhood Hits	34
SwissProt Accessions	Q8TCT7, O60365, Q567S3, Q8IUH9, Q9BUY6, Q9H3M4, Q9NPN2, Q9P1Z6	Gene names	SPPL2B, KIAA1532, PSL1
Domain Architecture
Description	Signal peptide peptidase-like 2B (EC 3.4.23.-) (Protein SPP-like 2B) (Protein SPPL2b) (Intramembrane protease 4) (IMP4) (Presenilin-like protein 1).

OGFR_HUMAN
NC score	0.040021 (rank : 77)	θ value	0.0431538 (rank : 36)
Query Neighborhood Hits	165	Target Neighborhood Hits	1582	Shared Neighborhood Hits	57
SwissProt Accessions	Q9NZT2, O96029, Q4VXW5, Q96CM2, Q9BQW1, Q9H4H0, Q9H7J5, Q9NZT3, Q9NZT4	Gene names	OGFR
Domain Architecture
Description	Opioid growth factor receptor (OGFr) (Zeta-type opioid receptor) (7-60 protein).

KCNQ2_MOUSE
NC score	0.039826 (rank : 78)	θ value	3.0926 (rank : 98)
Query Neighborhood Hits	165	Target Neighborhood Hits	163	Shared Neighborhood Hits	45
SwissProt Accessions	Q9Z351, Q8R498, Q9QWN9, Q9Z342, Q9Z343, Q9Z344, Q9Z345, Q9Z346, Q9Z347, Q9Z348, Q9Z349, Q9Z350	Gene names	Kcnq2, Kqt2
Domain Architecture
Description	Potassium voltage-gated channel subfamily KQT member 2 (Voltage-gated potassium channel subunit Kv7.2) (Potassium channel subunit alpha KvLQT2) (KQT-like 2).

RPGF4_HUMAN
NC score	0.039516 (rank : 79)	θ value	4.03905 (rank : 115)
Query Neighborhood Hits	165	Target Neighborhood Hits	88	Shared Neighborhood Hits	20
SwissProt Accessions	Q8WZA2, O95636, Q8IXK6, Q8TAA4	Gene names	RAPGEF4, CGEF2, EPAC2
Domain Architecture
Description	Rap guanine nucleotide exchange factor 4 (cAMP-regulated guanine nucleotide exchange factor II) (cAMP-GEFII) (Exchange factor directly activated by cAMP 2) (Epac 2).

RGS3_MOUSE
NC score	0.034471 (rank : 80)	θ value	0.47712 (rank : 58)
Query Neighborhood Hits	165	Target Neighborhood Hits	1621	Shared Neighborhood Hits	62
SwissProt Accessions	Q9DC04, Q5SRB1, Q5SRB4, Q5SRB8, Q8CEE3, Q8VI25, Q925G9, Q9JL22, Q9JL23, Q9QXA2	Gene names	Rgs3
Domain Architecture
Description	Regulator of G-protein signaling 3 (RGS3) (C2PA).

KCNN4_HUMAN
NC score	0.034263 (rank : 81)	θ value	5.27518 (rank : 122)
Query Neighborhood Hits	165	Target Neighborhood Hits	90	Shared Neighborhood Hits	36
SwissProt Accessions	O15554	Gene names	KCNN4, IK1, IKCA1, KCA4, SK4
Domain Architecture
Description	Intermediate conductance calcium-activated potassium channel protein 4 (SK4) (KCa4) (IK1) (IKCa1) (Putative Gardos channel).

NRG2_MOUSE
NC score	0.033621 (rank : 82)	θ value	0.0148317 (rank : 34)
Query Neighborhood Hits	165	Target Neighborhood Hits	392	Shared Neighborhood Hits	10
SwissProt Accessions	P56974	Gene names	Nrg2
Domain Architecture	No domain graphic available
Description	Pro-neuregulin-2, membrane-bound isoform precursor (Pro-NRG2) [Contains: Neuregulin-2 (NRG-2) (Divergent of neuregulin 1) (DON-1)].

NACAM_MOUSE
NC score	0.033393 (rank : 83)	θ value	6.88961 (rank : 142)
Query Neighborhood Hits	165	Target Neighborhood Hits	1866	Shared Neighborhood Hits	65
SwissProt Accessions	P70670	Gene names	Naca
Domain Architecture	No domain graphic available
Description	Nascent polypeptide-associated complex subunit alpha, muscle-specific form (Alpha-NAC, muscle-specific form).

NRG2_HUMAN
NC score	0.033261 (rank : 84)	θ value	0.125558 (rank : 42)
Query Neighborhood Hits	165	Target Neighborhood Hits	419	Shared Neighborhood Hits	18
SwissProt Accessions	O14511	Gene names	NRG2, NTAK
Domain Architecture
Description	Pro-neuregulin-2, membrane-bound isoform precursor (Pro-NRG2) [Contains: Neuregulin-2 (NRG-2) (Neural- and thymus-derived activator for ERBB kinases) (NTAK) (Divergent of neuregulin-1) (DON-1)].

MAGE1_HUMAN
NC score	0.032958 (rank : 85)	θ value	0.62314 (rank : 61)
Query Neighborhood Hits	165	Target Neighborhood Hits	1389	Shared Neighborhood Hits	62
SwissProt Accessions	Q9HCI5, Q86TG0, Q8TD92, Q9H216	Gene names	MAGEE1, HCA1, KIAA1587
Domain Architecture	No domain graphic available
Description	Melanoma-associated antigen E1 (MAGE-E1 antigen) (Hepatocellular carcinoma-associated protein 1).

ZAR1_MOUSE
NC score	0.031075 (rank : 86)	θ value	0.0961366 (rank : 41)
Query Neighborhood Hits	165	Target Neighborhood Hits	254	Shared Neighborhood Hits	10
SwissProt Accessions	Q80SU3	Gene names	Zar1
Domain Architecture	No domain graphic available
Description	Zygote arrest 1 (Oocyte-specific maternal effect factor).

KCNN4_MOUSE
NC score	0.030892 (rank : 87)	θ value	6.88961 (rank : 139)
Query Neighborhood Hits	165	Target Neighborhood Hits	85	Shared Neighborhood Hits	37
SwissProt Accessions	O89109, Q3U1J8, Q9CY39	Gene names	Kcnn4
Domain Architecture
Description	Intermediate conductance calcium-activated potassium channel protein 4 (SK4) (KCa4) (IK1).

SRRM2_MOUSE
NC score	0.030292 (rank : 88)	θ value	8.99809 (rank : 164)
Query Neighborhood Hits	165	Target Neighborhood Hits	1470	Shared Neighborhood Hits	49
SwissProt Accessions	Q8BTI8, Q3TBY5, Q569P9, Q80U37, Q8K383	Gene names	Srrm2, Kiaa0324
Domain Architecture	No domain graphic available
Description	Serine/arginine repetitive matrix protein 2.

HSF1_MOUSE
NC score	0.028412 (rank : 89)	θ value	0.365318 (rank : 49)
Query Neighborhood Hits	165	Target Neighborhood Hits	267	Shared Neighborhood Hits	16
SwissProt Accessions	P38532, O70462	Gene names	Hsf1
Domain Architecture
Description	Heat shock factor protein 1 (HSF 1) (Heat shock transcription factor 1) (HSTF 1).

ATPD_HUMAN
NC score	0.027421 (rank : 90)	θ value	3.0926 (rank : 91)
Query Neighborhood Hits	165	Target Neighborhood Hits	6	Shared Neighborhood Hits	3
SwissProt Accessions	P30049	Gene names	ATP5D
Domain Architecture
Description	ATP synthase delta chain, mitochondrial precursor (EC 3.6.3.14).

NRX2A_HUMAN
NC score	0.027376 (rank : 91)	θ value	0.365318 (rank : 52)
Query Neighborhood Hits	165	Target Neighborhood Hits	614	Shared Neighborhood Hits	19
SwissProt Accessions	Q9P2S2, Q9Y2D6	Gene names	NRXN2, KIAA0921
Domain Architecture
Description	Neurexin-2-alpha precursor (Neurexin II-alpha).

SRRM1_HUMAN
NC score	0.026321 (rank : 92)	θ value	4.03905 (rank : 117)
Query Neighborhood Hits	165	Target Neighborhood Hits	690	Shared Neighborhood Hits	28
SwissProt Accessions	Q8IYB3, O60585, Q5VVN4	Gene names	SRRM1, SRM160
Domain Architecture	No domain graphic available
Description	Serine/arginine repetitive matrix protein 1 (Ser/Arg-related nuclear matrix protein) (SR-related nuclear matrix protein of 160 kDa) (SRm160).

SNPC4_HUMAN
NC score	0.025312 (rank : 93)	θ value	1.38821 (rank : 73)
Query Neighborhood Hits	165	Target Neighborhood Hits	589	Shared Neighborhood Hits	30
SwissProt Accessions	Q5SXM2, Q9Y6P7	Gene names	SNAPC4, SNAP190
Domain Architecture	No domain graphic available
Description	snRNA-activating protein complex subunit 4 (SNAPc subunit 4) (snRNA- activating protein complex 190 kDa subunit) (SNAPc 190 kDa subunit) (Proximal sequence element-binding transcription factor subunit alpha) (PSE-binding factor subunit alpha) (PTF subunit alpha).

SRRM1_MOUSE
NC score	0.023782 (rank : 94)	θ value	8.99809 (rank : 163)
Query Neighborhood Hits	165	Target Neighborhood Hits	966	Shared Neighborhood Hits	38
SwissProt Accessions	Q52KI8, O70495, Q9CVG5	Gene names	Srrm1, Pop101
Domain Architecture	No domain graphic available
Description	Serine/arginine repetitive matrix protein 1 (Plenty-of-prolines 101).

TCOF_MOUSE
NC score	0.023591 (rank : 95)	θ value	0.62314 (rank : 63)
Query Neighborhood Hits	165	Target Neighborhood Hits	471	Shared Neighborhood Hits	14
SwissProt Accessions	O08784, O08857	Gene names	Tcof1
Domain Architecture
Description	Treacle protein (Treacher Collins syndrome protein homolog).

T22D4_HUMAN
NC score	0.023336 (rank : 96)	θ value	5.27518 (rank : 126)
Query Neighborhood Hits	165	Target Neighborhood Hits	403	Shared Neighborhood Hits	26
SwissProt Accessions	Q9Y3Q8	Gene names	TSC22D4, TILZ2
Domain Architecture
Description	TSC22 domain family protein 4 (TSC22-related-inducible leucine zipper protein 2) (Tsc-22-like protein THG-1).

CA106_MOUSE
NC score	0.023246 (rank : 97)	θ value	6.88961 (rank : 132)
Query Neighborhood Hits	165	Target Neighborhood Hits	89	Shared Neighborhood Hits	7
SwissProt Accessions	Q7TN12, Q7TN27, Q8BGK3	Gene names
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C1orf106 homolog.

TCOF_HUMAN
NC score	0.022634 (rank : 98)	θ value	2.36792 (rank : 88)
Query Neighborhood Hits	165	Target Neighborhood Hits	543	Shared Neighborhood Hits	23
SwissProt Accessions	Q13428, Q99408, Q99860	Gene names	TCOF1
Domain Architecture
Description	Treacle protein (Treacher Collins syndrome protein).

HAIR_HUMAN
NC score	0.022464 (rank : 99)	θ value	8.99809 (rank : 158)
Query Neighborhood Hits	165	Target Neighborhood Hits	172	Shared Neighborhood Hits	13
SwissProt Accessions	O43593, Q96H33, Q9NPE1	Gene names	HR
Domain Architecture
Description	Protein hairless.

ADRM1_HUMAN
NC score	0.022255 (rank : 100)	θ value	3.0926 (rank : 90)
Query Neighborhood Hits	165	Target Neighborhood Hits	81	Shared Neighborhood Hits	10
SwissProt Accessions	Q16186, Q9H1P2	Gene names	ADRM1, GP110
Domain Architecture
Description	Adhesion-regulating molecule 1 precursor (110 kDa cell membrane glycoprotein) (Gp110).

TOPRS_MOUSE
NC score	0.021598 (rank : 101)	θ value	2.36792 (rank : 89)
Query Neighborhood Hits	165	Target Neighborhood Hits	263	Shared Neighborhood Hits	6
SwissProt Accessions	Q80Z37, Q3U5B5, Q3UPZ1, Q3USN3, Q3UZ55, Q8BXP2, Q8CFF5, Q8CGC8, Q920L3	Gene names	Topors
Domain Architecture	No domain graphic available
Description	Ubiquitin-protein E3 ligase Topors (EC 6.3.2.-) (SUMO1-protein E3 ligase Topors) (Topoisomerase I-binding RING finger protein) (Topoisomerase I-binding arginine/serine-rich protein) (Tumor suppressor p53-binding protein 3) (p53-binding protein 3) (p53BP3).

TCGAP_HUMAN
NC score	0.021532 (rank : 102)	θ value	0.365318 (rank : 54)
Query Neighborhood Hits	165	Target Neighborhood Hits	872	Shared Neighborhood Hits	33
SwissProt Accessions	O14559, O14552, O14560, Q6ZSP6, Q96CP3, Q9NT23	Gene names	SNX26, TCGAP
Domain Architecture
Description	TC10/CDC42 GTPase-activating protein (Sorting nexin-26).

CI150_MOUSE
NC score	0.020453 (rank : 103)	θ value	4.03905 (rank : 107)
Query Neighborhood Hits	165	Target Neighborhood Hits	10	Shared Neighborhood Hits	3
SwissProt Accessions	Q8K2P1, Q9D150	Gene names	D4Bwg0951e
Domain Architecture	No domain graphic available
Description	Protein C9orf150 homolog.

SON_HUMAN
NC score	0.019353 (rank : 104)	θ value	0.62314 (rank : 62)
Query Neighborhood Hits	165	Target Neighborhood Hits	1568	Shared Neighborhood Hits	48
SwissProt Accessions	P18583, O14487, O95981, Q14120, Q9H7B1, Q9P070, Q9P072, Q9UKP9, Q9UPY0	Gene names	SON, C21orf50, DBP5, KIAA1019, NREBP
Domain Architecture
Description	SON protein (SON3) (Negative regulatory element-binding protein) (NRE- binding protein) (DBP-5) (Bax antagonist selected in saccharomyces 1) (BASS1).

SCN7A_HUMAN
NC score	0.019201 (rank : 105)	θ value	0.0252991 (rank : 35)
Query Neighborhood Hits	165	Target Neighborhood Hits	135	Shared Neighborhood Hits	11
SwissProt Accessions	Q01118	Gene names	SCN7A, SCN6A
Domain Architecture
Description	Sodium channel protein type 7 subunit alpha (Sodium channel protein type VII subunit alpha) (Putative voltage-gated sodium channel alpha subunit Nax) (Sodium channel protein, cardiac and skeletal muscle alpha-subunit).

ADRM1_MOUSE
NC score	0.017168 (rank : 106)	θ value	8.99809 (rank : 154)
Query Neighborhood Hits	165	Target Neighborhood Hits	84	Shared Neighborhood Hits	9
SwissProt Accessions	Q9JKV1	Gene names	Adrm1, Gp110
Domain Architecture
Description	Adhesion-regulating molecule 1 precursor (110 kDa cell membrane glycoprotein) (Gp110) (ARM-1).

IF4G1_MOUSE
NC score	0.016664 (rank : 107)	θ value	8.99809 (rank : 159)
Query Neighborhood Hits	165	Target Neighborhood Hits	534	Shared Neighborhood Hits	20
SwissProt Accessions	Q6NZJ6, Q6NZN8, Q8BW99	Gene names	Eif4g1
Domain Architecture	No domain graphic available
Description	Eukaryotic translation initiation factor 4 gamma 1 (eIF-4-gamma 1) (eIF-4G1) (eIF-4G 1).

FOXN1_HUMAN
NC score	0.016467 (rank : 108)	θ value	2.36792 (rank : 81)
Query Neighborhood Hits	165	Target Neighborhood Hits	377	Shared Neighborhood Hits	18
SwissProt Accessions	O15353, O15352	Gene names	FOXN1, WHN
Domain Architecture
Description	Forkhead box protein N1 (Transcription factor winged-helix nude).

VINC_HUMAN
NC score	0.016132 (rank : 109)	θ value	3.0926 (rank : 103)
Query Neighborhood Hits	165	Target Neighborhood Hits	145	Shared Neighborhood Hits	8
SwissProt Accessions	P18206, Q16450, Q5SWX2, Q7Z3B8, Q8IXU7	Gene names	VCL
Domain Architecture
Description	Vinculin (Metavinculin).

REL1_MOUSE
NC score	0.015653 (rank : 110)	θ value	6.88961 (rank : 144)
Query Neighborhood Hits	165	Target Neighborhood Hits	11	Shared Neighborhood Hits	3
SwissProt Accessions	P47932	Gene names	Rln1, Rln, Rlx
Domain Architecture
Description	Prorelaxin 1 precursor [Contains: Relaxin B chain; Relaxin A chain].

FRS3_MOUSE
NC score	0.015563 (rank : 111)	θ value	8.99809 (rank : 157)
Query Neighborhood Hits	165	Target Neighborhood Hits	168	Shared Neighborhood Hits	13
SwissProt Accessions	Q91WJ0	Gene names	Frs3, Frs2b
Domain Architecture	No domain graphic available
Description	Fibroblast growth factor receptor substrate 3 (FGFR substrate 3) (FRS2-beta).

CAC1G_HUMAN
NC score	0.015255 (rank : 112)	θ value	8.99809 (rank : 156)
Query Neighborhood Hits	165	Target Neighborhood Hits	587	Shared Neighborhood Hits	34
SwissProt Accessions	O43497, O43498, O94770, Q9NYU4, Q9NYU5, Q9NYU6, Q9NYU7, Q9NYU8, Q9NYU9, Q9NYV0, Q9NYV1, Q9UHN9, Q9UHP0, Q9ULU6, Q9UNG7, Q9Y5T2, Q9Y5T3	Gene names	CACNA1G, KIAA1123
Domain Architecture
Description	Voltage-dependent T-type calcium channel subunit alpha-1G (Voltage- gated calcium channel subunit alpha Cav3.1) (Cav3.1c) (NBR13).

VINC_MOUSE
NC score	0.015044 (rank : 113)	θ value	3.0926 (rank : 104)
Query Neighborhood Hits	165	Target Neighborhood Hits	135	Shared Neighborhood Hits	8
SwissProt Accessions	Q64727, Q8BP32, Q8BS46, Q922C5, Q922D9	Gene names	Vcl
Domain Architecture
Description	Vinculin (Metavinculin).

IL4RA_HUMAN
NC score	0.014877 (rank : 114)	θ value	3.0926 (rank : 93)
Query Neighborhood Hits	165	Target Neighborhood Hits	144	Shared Neighborhood Hits	11
SwissProt Accessions	P24394, Q96P01, Q9H181, Q9H182, Q9H183, Q9H184, Q9H185, Q9H186, Q9H187, Q9H188	Gene names	IL4R, 582J2.1, IL4RA
Domain Architecture
Description	Interleukin-4 receptor alpha chain precursor (IL-4R-alpha) (CD124 antigen) [Contains: Soluble interleukin-4 receptor alpha chain (sIL4Ralpha/prot) (IL-4-binding protein) (IL4-BP)].

ZP1_MOUSE
NC score	0.014285 (rank : 115)	θ value	3.0926 (rank : 105)
Query Neighborhood Hits	165	Target Neighborhood Hits	43	Shared Neighborhood Hits	3
SwissProt Accessions	Q62005, Q62016	Gene names	Zp1
Domain Architecture
Description	Zona pellucida sperm-binding protein 1 precursor (Zona pellucida glycoprotein 1) (Zp-1).

MNAB_HUMAN
NC score	0.014176 (rank : 116)	θ value	1.81305 (rank : 78)
Query Neighborhood Hits	165	Target Neighborhood Hits	196	Shared Neighborhood Hits	5
SwissProt Accessions	Q9HBD1, Q5JPD7, Q86ST6, Q8N3D6, Q96F27, Q9H5J2, Q9HBD2, Q9NWN9, Q9NXE1	Gene names	MNAB, RNF164
Domain Architecture	No domain graphic available
Description	Membrane-associated nucleic acid-binding protein (RING finger protein 164).

SRRM2_HUMAN
NC score	0.014064 (rank : 117)	θ value	4.03905 (rank : 118)
Query Neighborhood Hits	165	Target Neighborhood Hits	1296	Shared Neighborhood Hits	40
SwissProt Accessions	Q9UQ35, O15038, O94803, Q6NSL3, Q6PIM3, Q6PK40, Q8IW17, Q96GY7, Q9P0G1, Q9UHA8, Q9UQ36, Q9UQ37, Q9UQ38, Q9UQ40	Gene names	SRRM2, KIAA0324, SRL300, SRM300
Domain Architecture	No domain graphic available
Description	Serine/arginine repetitive matrix protein 2 (Serine/arginine-rich splicing factor-related nuclear matrix protein of 300 kDa) (Ser/Arg- related nuclear matrix protein) (SR-related nuclear matrix protein of 300 kDa) (Splicing coactivator subunit SRm300) (300 kDa nuclear matrix antigen).

AFF1_MOUSE
NC score	0.013841 (rank : 118)	θ value	4.03905 (rank : 106)
Query Neighborhood Hits	165	Target Neighborhood Hits	351	Shared Neighborhood Hits	19
SwissProt Accessions	O88573	Gene names	Aff1, Mllt2, Mllt2h
Domain Architecture
Description	AF4/FMR2 family member 1 (Protein AF-4) (Proto-oncogene AF4).

WASIP_HUMAN
NC score	0.013821 (rank : 119)	θ value	6.88961 (rank : 150)
Query Neighborhood Hits	165	Target Neighborhood Hits	458	Shared Neighborhood Hits	30
SwissProt Accessions	O43516, Q15220, Q6MZU9, Q9BU37, Q9UNP1	Gene names	WASPIP, WIP
Domain Architecture	No domain graphic available
Description	Wiskott-Aldrich syndrome protein-interacting protein (WASP-interacting protein) (PRPL-2 protein).

CT151_HUMAN
NC score	0.013425 (rank : 120)	θ value	3.0926 (rank : 92)
Query Neighborhood Hits	165	Target Neighborhood Hits	382	Shared Neighborhood Hits	15
SwissProt Accessions	Q8NC74, Q8N4Z9, Q9BR75, Q9H0Y9	Gene names	C20orf151
Domain Architecture
Description	Uncharacterized protein C20orf151.

RGS14_HUMAN
NC score	0.013127 (rank : 121)	θ value	1.81305 (rank : 79)
Query Neighborhood Hits	165	Target Neighborhood Hits	77	Shared Neighborhood Hits	5
SwissProt Accessions	O43566, O43565, Q8TD62	Gene names	RGS14
Domain Architecture
Description	Regulator of G-protein signaling 14 (RGS14).

PRAX_HUMAN
NC score	0.013026 (rank : 122)	θ value	3.0926 (rank : 101)
Query Neighborhood Hits	165	Target Neighborhood Hits	215	Shared Neighborhood Hits	9
SwissProt Accessions	Q9BXM0, Q9BXL9, Q9HCF2	Gene names	PRX, KIAA1620
Domain Architecture
Description	Periaxin.

PRAX_MOUSE
NC score	0.012764 (rank : 123)	θ value	5.27518 (rank : 125)
Query Neighborhood Hits	165	Target Neighborhood Hits	199	Shared Neighborhood Hits	10
SwissProt Accessions	O55103, O55104	Gene names	Prx
Domain Architecture
Description	Periaxin.

TOPRS_HUMAN
NC score	0.012271 (rank : 124)	θ value	6.88961 (rank : 149)
Query Neighborhood Hits	165	Target Neighborhood Hits	286	Shared Neighborhood Hits	6
SwissProt Accessions	Q9NS56, O43273, Q6P987, Q9NS55, Q9UNR9	Gene names	TOPORS, LUN, TP53BPL
Domain Architecture	No domain graphic available
Description	Ubiquitin-protein E3 ligase Topors (EC 6.3.2.-) (SUMO1-protein E3 ligase Topors) (Topoisomerase I-binding RING finger protein) (Topoisomerase I-binding arginine/serine-rich protein) (Tumor suppressor p53-binding protein 3) (p53-binding protein 3) (p53BP3).

GNAS1_HUMAN
NC score	0.011769 (rank : 125)	θ value	4.03905 (rank : 111)
Query Neighborhood Hits	165	Target Neighborhood Hits	278	Shared Neighborhood Hits	19
SwissProt Accessions	Q5JWF2, O75684, O75685, Q5JW67, Q5JWF1, Q9NY42	Gene names	GNAS, GNAS1
Domain Architecture	No domain graphic available
Description	Guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas (Adenylate cyclase-stimulating G alpha protein) (Extra large alphas protein) (XLalphas).

AF17_HUMAN
NC score	0.011735 (rank : 126)	θ value	5.27518 (rank : 120)
Query Neighborhood Hits	165	Target Neighborhood Hits	230	Shared Neighborhood Hits	15
SwissProt Accessions	P55198, Q9UF49	Gene names	MLLT6, AF17
Domain Architecture
Description	Protein AF-17.

ABD12_HUMAN
NC score	0.011697 (rank : 127)	θ value	8.99809 (rank : 152)
Query Neighborhood Hits	165	Target Neighborhood Hits	10	Shared Neighborhood Hits	4
SwissProt Accessions	Q8N2K0, Q5T710, Q96CR1, Q9BX05, Q9NPX7, Q9UFV6	Gene names	Abhd12, C20orf22
Domain Architecture
Description	Abhydrolase domain-containing protein 12.

ABD12_MOUSE
NC score	0.011691 (rank : 128)	θ value	8.99809 (rank : 153)
Query Neighborhood Hits	165	Target Neighborhood Hits	13	Shared Neighborhood Hits	4
SwissProt Accessions	Q99LR1, Q99M06	Gene names	Abhd12
Domain Architecture
Description	Abhydrolase domain-containing protein 12.

CAC1B_MOUSE
NC score	0.011654 (rank : 129)	θ value	6.88961 (rank : 133)
Query Neighborhood Hits	165	Target Neighborhood Hits	351	Shared Neighborhood Hits	29
SwissProt Accessions	O55017, Q60609	Gene names	Cacna1b, Cach5, Cacnl1a5, Cchn1a
Domain Architecture
Description	Voltage-dependent N-type calcium channel subunit alpha-1B (Voltage- gated calcium channel subunit alpha Cav2.2) (Calcium channel, L type, alpha-1 polypeptide isoform 5) (Brain calcium channel III) (BIII).

3BHS7_MOUSE
NC score	0.011100 (rank : 130)	θ value	5.27518 (rank : 119)
Query Neighborhood Hits	165	Target Neighborhood Hits	21	Shared Neighborhood Hits	4
SwissProt Accessions	Q9EQC1	Gene names	Hsd3b7
Domain Architecture
Description	3 beta-hydroxysteroid dehydrogenase type 7 (3 beta-hydroxysteroid dehydrogenase type VII) (3Beta-HSD VII) (3-beta-hydroxy-delta(5)-C27 steroid oxidoreductase) (EC 1.1.1.-) (C(27) 3beta-HSD).

RP1L1_MOUSE
NC score	0.010931 (rank : 131)	θ value	6.88961 (rank : 145)
Query Neighborhood Hits	165	Target Neighborhood Hits	170	Shared Neighborhood Hits	11
SwissProt Accessions	Q8CGM2, Q8K0I4	Gene names	Rp1l1, Rp1hl1
Domain Architecture
Description	Retinitis pigmentosa 1-like 1 protein (Retinitis pigmentosa 1-like protein 1).

JIP2_HUMAN
NC score	0.010537 (rank : 132)	θ value	4.03905 (rank : 112)
Query Neighborhood Hits	165	Target Neighborhood Hits	288	Shared Neighborhood Hits	11
SwissProt Accessions	Q13387, Q96G62, Q99771, Q9NZ59, Q9UKQ4	Gene names	MAPK8IP2, IB2, JIP2
Domain Architecture
Description	C-jun-amino-terminal kinase-interacting protein 2 (JNK-interacting protein 2) (JIP-2) (JNK MAP kinase scaffold protein 2) (Islet-brain-2) (IB-2) (Mitogen-activated protein kinase 8-interacting protein 2).

CBL_HUMAN
NC score	0.010355 (rank : 133)	θ value	6.88961 (rank : 134)
Query Neighborhood Hits	165	Target Neighborhood Hits	353	Shared Neighborhood Hits	15
SwissProt Accessions	P22681	Gene names	CBL, CBL2, RNF55
Domain Architecture
Description	E3 ubiquitin-protein ligase CBL (EC 6.3.2.-) (Signal transduction protein CBL) (Proto-oncogene c-CBL) (Casitas B-lineage lymphoma proto- oncogene) (RING finger protein 55).

IF4G1_HUMAN
NC score	0.010125 (rank : 134)	θ value	6.88961 (rank : 138)
Query Neighborhood Hits	165	Target Neighborhood Hits	347	Shared Neighborhood Hits	20
SwissProt Accessions	Q04637, O43177, O95066, Q5HYG0, Q6ZN21, Q8N102	Gene names	EIF4G1, EIF4G, EIF4GI
Domain Architecture
Description	Eukaryotic translation initiation factor 4 gamma 1 (eIF-4-gamma 1) (eIF-4G1) (eIF-4G 1) (p220).

NCA11_MOUSE
NC score	0.009923 (rank : 135)	θ value	0.279714 (rank : 48)
Query Neighborhood Hits	165	Target Neighborhood Hits	661	Shared Neighborhood Hits	18
SwissProt Accessions	P13595, Q61949	Gene names	Ncam1, Ncam
Domain Architecture
Description	Neural cell adhesion molecule 1, 180 kDa isoform precursor (N-CAM 180) (NCAM-180).

NGN2_HUMAN
NC score	0.009800 (rank : 136)	θ value	0.813845 (rank : 68)
Query Neighborhood Hits	165	Target Neighborhood Hits	92	Shared Neighborhood Hits	2
SwissProt Accessions	Q9H2A3, Q8N416	Gene names	NEUROG2, NGN2
Domain Architecture	No domain graphic available
Description	Neurogenin 2.

PER1_MOUSE
NC score	0.009729 (rank : 137)	θ value	3.0926 (rank : 100)
Query Neighborhood Hits	165	Target Neighborhood Hits	235	Shared Neighborhood Hits	16
SwissProt Accessions	O35973	Gene names	Per1, Per, Rigui
Domain Architecture
Description	Period circadian protein 1 (Circadian pacemaker protein Rigui) (mPER) (M-Rigui).

ZN516_MOUSE
NC score	0.009527 (rank : 138)	θ value	0.21417 (rank : 45)
Query Neighborhood Hits	165	Target Neighborhood Hits	1197	Shared Neighborhood Hits	36
SwissProt Accessions	Q7TSH3	Gene names	Znf516, Kiaa0222, Zfp516
Domain Architecture
Description	Zinc finger protein 516.

WBP1_MOUSE
NC score	0.009469 (rank : 139)	θ value	5.27518 (rank : 127)
Query Neighborhood Hits	165	Target Neighborhood Hits	12	Shared Neighborhood Hits	2
SwissProt Accessions	P97764, Q8WUP5, Q99J20	Gene names	Wbp1
Domain Architecture	No domain graphic available
Description	WW domain-binding protein 1 (WBP-1).

SYNG_HUMAN
NC score	0.009433 (rank : 140)	θ value	6.88961 (rank : 146)
Query Neighborhood Hits	165	Target Neighborhood Hits	160	Shared Neighborhood Hits	10
SwissProt Accessions	Q9UMZ2, Q6ZT17	Gene names	AP1GBP1, SYNG
Domain Architecture	No domain graphic available
Description	AP1 subunit gamma-binding protein 1 (Gamma-synergin).

PHLPP_HUMAN
NC score	0.009336 (rank : 141)	θ value	6.88961 (rank : 143)
Query Neighborhood Hits	165	Target Neighborhood Hits	604	Shared Neighborhood Hits	21
SwissProt Accessions	O60346, Q641Q7, Q6P4C4, Q6PJI6, Q86TN6, Q96FK2, Q9NUY1	Gene names	PHLPP, KIAA0606, PLEKHE1, SCOP
Domain Architecture	No domain graphic available
Description	PH domain leucine-rich repeat-containing protein phosphatase (EC 3.1.3.16) (PH domain leucine-rich repeat protein phosphatase) (Pleckstrin homology domain-containing family E protein 1) (Suprachiasmatic nucleus circadian oscillatory protein) (hSCOP).

AP180_MOUSE
NC score	0.008234 (rank : 142)	θ value	6.88961 (rank : 128)
Query Neighborhood Hits	165	Target Neighborhood Hits	194	Shared Neighborhood Hits	11
SwissProt Accessions	Q61548, Q61547	Gene names	Snap91
Domain Architecture
Description	Clathrin coat assembly protein AP180 (Clathrin coat-associated protein AP180) (91 kDa synaptosomal-associated protein) (Phosphoprotein F1- 20).

GP124_MOUSE
NC score	0.008034 (rank : 143)	θ value	0.813845 (rank : 64)
Query Neighborhood Hits	165	Target Neighborhood Hits	423	Shared Neighborhood Hits	9
SwissProt Accessions	Q91ZV8	Gene names	Gpr124, Tem5
Domain Architecture
Description	Probable G-protein coupled receptor 124 precursor (Tumor endothelial marker 5).

CEND3_HUMAN
NC score	0.007762 (rank : 144)	θ value	1.81305 (rank : 75)
Query Neighborhood Hits	165	Target Neighborhood Hits	275	Shared Neighborhood Hits	13
SwissProt Accessions	Q8WWN8	Gene names	CENTD3, ARAP3
Domain Architecture	No domain graphic available
Description	Centaurin-delta 3 (Cnt-d3) (Arf-GAP, Rho-GAP, ankyrin repeat and pleckstrin homology domain-containing protein 3).

ONEC2_HUMAN
NC score	0.007660 (rank : 145)	θ value	3.0926 (rank : 99)
Query Neighborhood Hits	165	Target Neighborhood Hits	115	Shared Neighborhood Hits	2
SwissProt Accessions	O95948	Gene names	ONECUT2
Domain Architecture
Description	One cut domain family member 2 (Transcription factor ONECUT-2) (OC-2).

SOCS7_MOUSE
NC score	0.007492 (rank : 146)	θ value	8.99809 (rank : 162)
Query Neighborhood Hits	165	Target Neighborhood Hits	154	Shared Neighborhood Hits	8
SwissProt Accessions	Q8VHQ2	Gene names	Socs7, Cish7, Nap4
Domain Architecture
Description	Suppressor of cytokine signaling 7 (SOCS-7).

MY18B_HUMAN
NC score	0.007395 (rank : 147)	θ value	0.163984 (rank : 44)
Query Neighborhood Hits	165	Target Neighborhood Hits	1299	Shared Neighborhood Hits	21
SwissProt Accessions	Q8IUG5, Q8NDI8, Q8TE65, Q8WWS0, Q96KH2, Q96KR8, Q96KR9	Gene names	MYO18B
Domain Architecture
Description	Myosin-18B (Myosin XVIIIb).

ISY1_HUMAN
NC score	0.006744 (rank : 148)	θ value	8.99809 (rank : 160)
Query Neighborhood Hits	165	Target Neighborhood Hits	31	Shared Neighborhood Hits	2
SwissProt Accessions	Q9ULR0, Q96IL2, Q9BT05	Gene names	KIAA1160
Domain Architecture	No domain graphic available
Description	Pre-mRNA-splicing factor ISY1 homolog.

ELF2_MOUSE
NC score	0.006403 (rank : 149)	θ value	4.03905 (rank : 108)
Query Neighborhood Hits	165	Target Neighborhood Hits	81	Shared Neighborhood Hits	5
SwissProt Accessions	Q9JHC9, Q6NST2, Q8BTX8, Q9JHC7, Q9JHC8, Q9JHD0	Gene names	Elf2, Nerf
Domain Architecture	No domain graphic available
Description	ETS-related transcription factor Elf-2 (E74-like factor 2) (New ETS- related factor).

ELF2_HUMAN
NC score	0.005310 (rank : 150)	θ value	6.88961 (rank : 136)
Query Neighborhood Hits	165	Target Neighborhood Hits	78	Shared Neighborhood Hits	3
SwissProt Accessions	Q15723, Q15724, Q15725, Q6P1K5	Gene names	ELF2, NERF
Domain Architecture	No domain graphic available
Description	ETS-related transcription factor Elf-2 (E74-like factor 2) (New ETS- related factor).

ZN409_HUMAN
NC score	0.005118 (rank : 151)	θ value	6.88961 (rank : 151)
Query Neighborhood Hits	165	Target Neighborhood Hits	842	Shared Neighborhood Hits	20
SwissProt Accessions	Q9UPU6	Gene names	ZNF409, KIAA1056
Domain Architecture	No domain graphic available
Description	Zinc finger protein 409.

FOG1_MOUSE
NC score	0.004590 (rank : 152)	θ value	6.88961 (rank : 137)
Query Neighborhood Hits	165	Target Neighborhood Hits	1237	Shared Neighborhood Hits	38
SwissProt Accessions	O35615	Gene names	Zfpm1, Fog, Fog1
Domain Architecture	No domain graphic available
Description	Zinc finger protein ZFPM1 (Zinc finger protein multitype 1) (Friend of GATA protein 1) (Friend of GATA-1) (FOG-1).

SEM5B_MOUSE
NC score	0.004565 (rank : 153)	θ value	1.81305 (rank : 80)
Query Neighborhood Hits	165	Target Neighborhood Hits	190	Shared Neighborhood Hits	6
SwissProt Accessions	Q60519	Gene names	Sema5b, Semag, SemG
Domain Architecture
Description	Semaphorin-5B precursor (Semaphorin G) (Sema G).

FOXO4_MOUSE
NC score	0.004479 (rank : 154)	θ value	4.03905 (rank : 109)
Query Neighborhood Hits	165	Target Neighborhood Hits	168	Shared Neighborhood Hits	9
SwissProt Accessions	Q9WVH3	Gene names	Mllt7, Afx, Afx1, Fkhr3, Foxo4
Domain Architecture
Description	Fork head domain transcription factor AFX1 (Afxh) (Forkhead box protein O4).

SEM5B_HUMAN
NC score	0.004381 (rank : 155)	θ value	2.36792 (rank : 87)
Query Neighborhood Hits	165	Target Neighborhood Hits	178	Shared Neighborhood Hits	6
SwissProt Accessions	Q9P283, Q6UY12	Gene names	SEMA5B, KIAA1445
Domain Architecture
Description	Semaphorin-5B precursor.

MAST4_HUMAN
NC score	0.003584 (rank : 156)	θ value	6.88961 (rank : 141)
Query Neighborhood Hits	165	Target Neighborhood Hits	1804	Shared Neighborhood Hits	49
SwissProt Accessions	O15021, Q6ZN07, Q96LY3	Gene names	MAST4, KIAA0303
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase 4 (EC 2.7.11.1).

PRGR_HUMAN
NC score	0.003471 (rank : 157)	θ value	3.0926 (rank : 102)
Query Neighborhood Hits	165	Target Neighborhood Hits	163	Shared Neighborhood Hits	11
SwissProt Accessions	P06401, Q9UPF7	Gene names	PGR, NR3C3
Domain Architecture
Description	Progesterone receptor (PR).

TLN2_MOUSE
NC score	0.003273 (rank : 158)	θ value	6.88961 (rank : 147)
Query Neighborhood Hits	165	Target Neighborhood Hits	149	Shared Neighborhood Hits	4
SwissProt Accessions	Q71LX4, Q8BWK0	Gene names	Tln2
Domain Architecture	No domain graphic available
Description	Talin-2.

TNKS1_HUMAN
NC score	0.002738 (rank : 159)	θ value	1.38821 (rank : 74)
Query Neighborhood Hits	165	Target Neighborhood Hits	477	Shared Neighborhood Hits	12
SwissProt Accessions	O95271, O95272	Gene names	TNKS, PARP5A, PARPL, TIN1, TINF1, TNKS1
Domain Architecture
Description	Tankyrase-1 (EC 2.4.2.30) (TANK1) (Tankyrase I) (TNKS-1) (TRF1- interacting ankyrin-related ADP-ribose polymerase).

DDX51_HUMAN
NC score	0.002241 (rank : 160)	θ value	6.88961 (rank : 135)
Query Neighborhood Hits	165	Target Neighborhood Hits	332	Shared Neighborhood Hits	10
SwissProt Accessions	Q8N8A6, Q5CZ71, Q8IXK5, Q96ED1	Gene names	DDX51
Domain Architecture	No domain graphic available
Description	ATP-dependent RNA helicase DDX51 (EC 3.6.1.-) (DEAD box protein 51).

AT10D_HUMAN
NC score	0.001813 (rank : 161)	θ value	6.88961 (rank : 129)
Query Neighborhood Hits	165	Target Neighborhood Hits	69	Shared Neighborhood Hits	2
SwissProt Accessions	Q9P241, Q8NC70, Q96SR3	Gene names	ATP10D, KIAA1487
Domain Architecture
Description	Probable phospholipid-transporting ATPase VD (EC 3.6.3.1) (ATPVD).

ATS2_MOUSE
NC score	0.000975 (rank : 162)	θ value	8.99809 (rank : 155)
Query Neighborhood Hits	165	Target Neighborhood Hits	179	Shared Neighborhood Hits	6
SwissProt Accessions	Q8C9W3	Gene names	Adamts2
Domain Architecture
Description	ADAMTS-2 precursor (EC 3.4.24.14) (A disintegrin and metalloproteinase with thrombospondin motifs 2) (ADAM-TS 2) (ADAM-TS2) (Procollagen I/II amino propeptide-processing enzyme) (Procollagen I N-proteinase) (PC I-NP) (Procollagen N-endopeptidase) (pNPI).

HGFA_HUMAN
NC score	0.000975 (rank : 163)	θ value	1.81305 (rank : 76)
Query Neighborhood Hits	165	Target Neighborhood Hits	436	Shared Neighborhood Hits	11
SwissProt Accessions	Q04756, Q14726	Gene names	HGFAC
Domain Architecture
Description	Hepatocyte growth factor activator precursor (EC 3.4.21.-) (HGF activator) (HGFA) [Contains: Hepatocyte growth factor activator short chain; Hepatocyte growth factor activator long chain].

TMPSD_HUMAN
NC score	0.000629 (rank : 164)	θ value	6.88961 (rank : 148)
Query Neighborhood Hits	165	Target Neighborhood Hits	333	Shared Neighborhood Hits	15
SwissProt Accessions	Q9BYE2, Q86YM4, Q96JY8, Q9BYE1	Gene names	TMPRSS13, MSP, TMPRSS11
Domain Architecture	No domain graphic available
Description	Transmembrane protease, serine 13 (EC 3.4.21.-) (Mosaic serine protease) (Membrane-type mosaic serine protease).

LTB1L_HUMAN
NC score	-0.000323 (rank : 165)	θ value	5.27518 (rank : 123)
Query Neighborhood Hits	165	Target Neighborhood Hits	553	Shared Neighborhood Hits	9
SwissProt Accessions	Q14766	Gene names	LTBP1
Domain Architecture
Description	Latent-transforming growth factor beta-binding protein, isoform 1L precursor (LTBP-1) (Transforming growth factor beta-1-binding protein 1) (TGF-beta1-BP-1).

NOTC3_HUMAN
NC score	-0.000485 (rank : 166)	θ value	8.99809 (rank : 161)
Query Neighborhood Hits	165	Target Neighborhood Hits	1062	Shared Neighborhood Hits	21
SwissProt Accessions	Q9UM47, Q9UEB3, Q9UPL3, Q9Y6L8	Gene names	NOTCH3
Domain Architecture
Description	Neurogenic locus notch homolog protein 3 precursor (Notch 3) [Contains: Notch 3 extracellular truncation; Notch 3 intracellular domain].

BC11B_MOUSE
NC score	-0.001595 (rank : 167)	θ value	6.88961 (rank : 131)
Query Neighborhood Hits	165	Target Neighborhood Hits	767	Shared Neighborhood Hits	13
SwissProt Accessions	Q99PV8, Q8C2I1, Q99PV6, Q99PV7, Q9JLF8	Gene names	Bcl11b, Ctip2, Rit1
Domain Architecture	No domain graphic available
Description	B-cell lymphoma/leukemia 11B (B-cell CLL/lymphoma 11B) (Radiation- induced tumor suppressor gene 1 protein) (mRit1) (COUP-TF-interacting protein 2).

BC11B_HUMAN
NC score	-0.001693 (rank : 168)	θ value	6.88961 (rank : 130)
Query Neighborhood Hits	165	Target Neighborhood Hits	761	Shared Neighborhood Hits	11
SwissProt Accessions	Q9C0K0, Q9H162	Gene names	BCL11B, CTIP2, RIT1
Domain Architecture	No domain graphic available
Description	B-cell lymphoma/leukemia 11B (B-cell CLL/lymphoma 11B) (Radiation- induced tumor suppressor gene 1 protein) (hRit1) (COUP-TF-interacting protein 2).

GLIS1_HUMAN
NC score	-0.002393 (rank : 169)	θ value	4.03905 (rank : 110)
Query Neighborhood Hits	165	Target Neighborhood Hits	748	Shared Neighborhood Hits	12
SwissProt Accessions	Q8NBF1, Q8N9V9	Gene names	GLIS1
Domain Architecture	No domain graphic available
Description	Zinc finger protein GLIS1 (GLI-similar 1).

ZNF31_HUMAN
NC score	-0.002439 (rank : 170)	θ value	0.813845 (rank : 69)
Query Neighborhood Hits	165	Target Neighborhood Hits	769	Shared Neighborhood Hits	10
SwissProt Accessions	P17040, Q96H84	Gene names	ZNF31, KOX29, ZNF360, ZSCAN20
Domain Architecture	No domain graphic available
Description	Zinc finger protein 31 (Zinc finger protein KOX29) (Zinc finger and SCAN domain-containing protein 20) (Zinc finger protein 360).

MK07_MOUSE
NC score	-0.002506 (rank : 171)	θ value	5.27518 (rank : 124)
Query Neighborhood Hits	165	Target Neighborhood Hits	1054	Shared Neighborhood Hits	23
SwissProt Accessions	Q9WVS8	Gene names	Mapk7, Erk5
Domain Architecture
Description	Mitogen-activated protein kinase 7 (EC 2.7.11.24) (Extracellular signal-regulated kinase 5) (ERK-5) (BMK1 kinase).

ZN167_HUMAN
NC score	-0.003912 (rank : 172)	θ value	8.99809 (rank : 165)
Query Neighborhood Hits	165	Target Neighborhood Hits	784	Shared Neighborhood Hits	11
SwissProt Accessions	Q9P0L1, Q6WL09, Q96FQ2	Gene names	ZNF167, ZNF448, ZNF64
Domain Architecture	No domain graphic available
Description	Zinc finger protein 167 (Zinc finger protein 64) (Zinc finger protein 448) (ZFP).