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Network neighborhood for query Sequence : KAP0_HUMAN

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KAP0_HUMAN
SwissProt Accessions	P10644, Q567S7	Gene names	PRKAR1A, PKR1, PRKAR1
Domain Architecture
Description	cAMP-dependent protein kinase type I-alpha regulatory subunit (Tissue- specific extinguisher 1) (TSE1).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

KAP0_HUMAN
θ value	0 (rank : 1)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	52	Target Neighborhood Hits	52	Shared Neighborhood Hits	52
SwissProt Accessions	P10644, Q567S7	Gene names	PRKAR1A, PKR1, PRKAR1
Domain Architecture
Description	cAMP-dependent protein kinase type I-alpha regulatory subunit (Tissue- specific extinguisher 1) (TSE1).

KAP0_MOUSE
θ value	0 (rank : 2)	NC score	0.997859 (rank : 2)
Query Neighborhood Hits	52	Target Neighborhood Hits	48	Shared Neighborhood Hits	47
SwissProt Accessions	Q9DBC7, Q3UKU7, Q9JHR5, Q9JHR6	Gene names	Prkar1a
Domain Architecture	No domain graphic available
Description	cAMP-dependent protein kinase type I-alpha regulatory subunit.

KAP1_HUMAN
θ value	1.27474e-179 (rank : 3)	NC score	0.992537 (rank : 4)
Query Neighborhood Hits	52	Target Neighborhood Hits	58	Shared Neighborhood Hits	42
SwissProt Accessions	P31321	Gene names	PRKAR1B
Domain Architecture
Description	cAMP-dependent protein kinase type I-beta regulatory subunit.

KAP1_MOUSE
θ value	1.27474e-179 (rank : 4)	NC score	0.994458 (rank : 3)
Query Neighborhood Hits	52	Target Neighborhood Hits	49	Shared Neighborhood Hits	42
SwissProt Accessions	P12849	Gene names	Prkar1b
Domain Architecture
Description	cAMP-dependent protein kinase type I-beta regulatory subunit.

KAP2_HUMAN
θ value	2.84138e-62 (rank : 5)	NC score	0.933480 (rank : 6)
Query Neighborhood Hits	52	Target Neighborhood Hits	48	Shared Neighborhood Hits	34
SwissProt Accessions	P13861, Q16823	Gene names	PRKAR2A, PKR2, PRKAR2
Domain Architecture
Description	cAMP-dependent protein kinase type II-alpha regulatory subunit.

KAP3_HUMAN
θ value	6.99855e-61 (rank : 6)	NC score	0.932957 (rank : 8)
Query Neighborhood Hits	52	Target Neighborhood Hits	40	Shared Neighborhood Hits	35
SwissProt Accessions	P31323	Gene names	PRKAR2B
Domain Architecture
Description	cAMP-dependent protein kinase type II-beta regulatory subunit.

KAP3_MOUSE
θ value	3.47335e-60 (rank : 7)	NC score	0.933016 (rank : 7)
Query Neighborhood Hits	52	Target Neighborhood Hits	43	Shared Neighborhood Hits	35
SwissProt Accessions	P31324, Q3UTZ1, Q80ZM4, Q8BRZ7	Gene names	Prkar2b
Domain Architecture	No domain graphic available
Description	cAMP-dependent protein kinase type II-beta regulatory subunit.

KAP2_MOUSE
θ value	1.31987e-59 (rank : 8)	NC score	0.935614 (rank : 5)
Query Neighborhood Hits	52	Target Neighborhood Hits	44	Shared Neighborhood Hits	33
SwissProt Accessions	P12367	Gene names	Prkar2a
Domain Architecture
Description	cAMP-dependent protein kinase type II-alpha regulatory subunit.

KGP1B_HUMAN
θ value	2.11701e-41 (rank : 9)	NC score	0.227799 (rank : 31)
Query Neighborhood Hits	52	Target Neighborhood Hits	921	Shared Neighborhood Hits	42
SwissProt Accessions	P14619	Gene names	PRKG1, PRKG1B, PRKGR1B
Domain Architecture
Description	cGMP-dependent protein kinase 1, beta isozyme (EC 2.7.11.12) (cGK 1 beta) (cGKI-beta).

KGP1B_MOUSE
θ value	4.71619e-41 (rank : 10)	NC score	0.227281 (rank : 32)
Query Neighborhood Hits	52	Target Neighborhood Hits	922	Shared Neighborhood Hits	42
SwissProt Accessions	Q9Z0Z0	Gene names	Prkg1, Prkg1b, Prkgr1b
Domain Architecture
Description	cGMP-dependent protein kinase 1, beta isozyme (EC 2.7.11.12) (cGK 1 beta) (cGKI-beta).

KGP1A_HUMAN
θ value	5.21438e-40 (rank : 11)	NC score	0.226282 (rank : 33)
Query Neighborhood Hits	52	Target Neighborhood Hits	901	Shared Neighborhood Hits	42
SwissProt Accessions	Q13976	Gene names	PRKG1, PRKGR1A
Domain Architecture
Description	cGMP-dependent protein kinase 1, alpha isozyme (EC 2.7.11.12) (CGK 1 alpha) (cGKI-alpha).

KGP2_HUMAN
θ value	3.86705e-35 (rank : 12)	NC score	0.223135 (rank : 35)
Query Neighborhood Hits	52	Target Neighborhood Hits	1023	Shared Neighborhood Hits	39
SwissProt Accessions	Q13237, O00125, O60916	Gene names	PRKG2, PRKGR2
Domain Architecture
Description	cGMP-dependent protein kinase 2 (EC 2.7.11.12) (CGK 2) (cGKII) (Type II cGMP-dependent protein kinase).

KGP2_MOUSE
θ value	6.59618e-35 (rank : 13)	NC score	0.223720 (rank : 34)
Query Neighborhood Hits	52	Target Neighborhood Hits	1029	Shared Neighborhood Hits	38
SwissProt Accessions	Q61410	Gene names	Prkg2, Prkgr2
Domain Architecture
Description	cGMP-dependent protein kinase 2 (EC 2.7.11.12) (CGK 2) (cGKII) (Type II cGMP-dependent protein kinase).

RPGF3_MOUSE
θ value	3.41135e-07 (rank : 14)	NC score	0.346980 (rank : 10)
Query Neighborhood Hits	52	Target Neighborhood Hits	54	Shared Neighborhood Hits	26
SwissProt Accessions	Q8VCC8, Q8BZK9, Q8R1R1	Gene names	Rapgef3, Epac, Epac1
Domain Architecture
Description	Rap guanine nucleotide exchange factor 3 (cAMP-regulated guanine nucleotide exchange factor I) (cAMP-GEFI) (Exchange factor directly activated by cAMP 1) (Epac 1).

RPGF3_HUMAN
θ value	4.45536e-07 (rank : 15)	NC score	0.344202 (rank : 11)
Query Neighborhood Hits	52	Target Neighborhood Hits	56	Shared Neighborhood Hits	26
SwissProt Accessions	O95398, O95634, Q8WVN0	Gene names	RAPGEF3, CGEF1, EPAC, EPAC1
Domain Architecture
Description	Rap guanine nucleotide exchange factor 3 (cAMP-regulated guanine nucleotide exchange factor I) (cAMP-GEFI) (Exchange factor directly activated by cAMP 1) (Epac 1) (Rap1 guanine-nucleotide-exchange factor directly activated by cAMP).

RPGF4_HUMAN
θ value	5.81887e-07 (rank : 16)	NC score	0.324242 (rank : 16)
Query Neighborhood Hits	52	Target Neighborhood Hits	88	Shared Neighborhood Hits	31
SwissProt Accessions	Q8WZA2, O95636, Q8IXK6, Q8TAA4	Gene names	RAPGEF4, CGEF2, EPAC2
Domain Architecture
Description	Rap guanine nucleotide exchange factor 4 (cAMP-regulated guanine nucleotide exchange factor II) (cAMP-GEFII) (Exchange factor directly activated by cAMP 2) (Epac 2).

RPGF4_MOUSE
θ value	7.59969e-07 (rank : 17)	NC score	0.323355 (rank : 17)
Query Neighborhood Hits	52	Target Neighborhood Hits	80	Shared Neighborhood Hits	31
SwissProt Accessions	Q9EQZ6, Q8VIP9, Q9CW52, Q9Z1P0	Gene names	Rapgef4, Cgef2, Epac2
Domain Architecture
Description	Rap guanine nucleotide exchange factor 4 (cAMP-regulated guanine nucleotide exchange factor II) (cAMP-GEFII) (Exchange factor directly activated by cAMP 2) (Epac 2) (cAMP-dependent Rap1 guanine-nucleotide exchange factor).

HCN4_MOUSE
θ value	9.92553e-07 (rank : 18)	NC score	0.324588 (rank : 15)
Query Neighborhood Hits	52	Target Neighborhood Hits	284	Shared Neighborhood Hits	38
SwissProt Accessions	O70507	Gene names	Hcn4, Bcng3
Domain Architecture
Description	Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 (Brain cyclic nucleotide-gated channel 3) (BCNG-3).

HCN4_HUMAN
θ value	1.29631e-06 (rank : 19)	NC score	0.318480 (rank : 18)
Query Neighborhood Hits	52	Target Neighborhood Hits	303	Shared Neighborhood Hits	38
SwissProt Accessions	Q9Y3Q4, Q9UMQ7	Gene names	HCN4
Domain Architecture
Description	Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4.

HCN2_HUMAN
θ value	1.09739e-05 (rank : 20)	NC score	0.324662 (rank : 14)
Query Neighborhood Hits	52	Target Neighborhood Hits	369	Shared Neighborhood Hits	40
SwissProt Accessions	Q9UL51, O60742, O60743, O75267, Q9UBS2	Gene names	HCN2, BCNG2
Domain Architecture
Description	Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 (Brain cyclic nucleotide-gated channel 2) (BCNG-2).

HCN2_MOUSE
θ value	1.09739e-05 (rank : 21)	NC score	0.328084 (rank : 13)
Query Neighborhood Hits	52	Target Neighborhood Hits	278	Shared Neighborhood Hits	39
SwissProt Accessions	O88703, O70506	Gene names	Hcn2, Bcng2, Hac1
Domain Architecture
Description	Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 (Brain cyclic nucleotide-gated channel 2) (BCNG-2) (Hyperpolarization-activated cation channel 1) (HAC-1).

HCN3_HUMAN
θ value	1.09739e-05 (rank : 22)	NC score	0.301109 (rank : 21)
Query Neighborhood Hits	52	Target Neighborhood Hits	99	Shared Neighborhood Hits	37
SwissProt Accessions	Q9P1Z3, Q4VX12, Q8N6W6, Q9BWQ2	Gene names	HCN3, KIAA1535
Domain Architecture
Description	Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 3.

HCN3_MOUSE
θ value	1.09739e-05 (rank : 23)	NC score	0.301688 (rank : 19)
Query Neighborhood Hits	52	Target Neighborhood Hits	112	Shared Neighborhood Hits	38
SwissProt Accessions	O88705	Gene names	Hcn3, Hac3
Domain Architecture
Description	Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 3 (Hyperpolarization-activated cation channel 3) (HAC-3).

HCN1_HUMAN
θ value	1.87187e-05 (rank : 24)	NC score	0.301563 (rank : 20)
Query Neighborhood Hits	52	Target Neighborhood Hits	120	Shared Neighborhood Hits	37
SwissProt Accessions	O60741	Gene names	HCN1, BCNG1
Domain Architecture
Description	Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1 (Brain cyclic nucleotide-gated channel 1) (BCNG-1).

HCN1_MOUSE
θ value	1.87187e-05 (rank : 25)	NC score	0.299784 (rank : 22)
Query Neighborhood Hits	52	Target Neighborhood Hits	172	Shared Neighborhood Hits	38
SwissProt Accessions	O88704, O54899, Q9D613	Gene names	Hcn1, Bcng1, Hac2
Domain Architecture
Description	Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1 (Brain cyclic nucleotide-gated channel 1) (BCNG-1) (Hyperpolarization-activated cation channel 2) (HAC-2).

CT152_MOUSE
θ value	0.000121331 (rank : 26)	NC score	0.444008 (rank : 9)
Query Neighborhood Hits	52	Target Neighborhood Hits	38	Shared Neighborhood Hits	36
SwissProt Accessions	Q9D5U8, Q8R083	Gene names
Domain Architecture
Description	Uncharacterized protein C20orf152 homolog.

CNGB3_MOUSE
θ value	0.00134147 (rank : 27)	NC score	0.294649 (rank : 23)
Query Neighborhood Hits	52	Target Neighborhood Hits	74	Shared Neighborhood Hits	41
SwissProt Accessions	Q9JJZ9	Gene names	Cngb3, Cng6
Domain Architecture
Description	Cyclic nucleotide-gated cation channel beta 3 (CNG channel beta 3) (Cyclic nucleotide-gated channel beta 3) (Cone photoreceptor cGMP- gated channel subunit beta) (Cyclic nucleotide-gated cation channel modulatory subunit) (Cyclic nucleotide-gated channel subunit CNG6).

CNGB3_HUMAN
θ value	0.00228821 (rank : 28)	NC score	0.293089 (rank : 24)
Query Neighborhood Hits	52	Target Neighborhood Hits	206	Shared Neighborhood Hits	40
SwissProt Accessions	Q9NQW8, Q9NRE9	Gene names	CNGB3
Domain Architecture
Description	Cyclic nucleotide-gated cation channel beta 3 (CNG channel beta 3) (Cyclic nucleotide-gated channel beta 3) (Cone photoreceptor cGMP- gated channel subunit beta) (Cyclic nucleotide-gated cation channel modulatory subunit).

TPGS1_MOUSE
θ value	0.00509761 (rank : 29)	NC score	0.106924 (rank : 50)
Query Neighborhood Hits	52	Target Neighborhood Hits	5	Shared Neighborhood Hits	4
SwissProt Accessions	Q99MS8, Q3U5Q9, Q9R0B5	Gene names	Gtrgeo22
Domain Architecture	No domain graphic available
Description	Tubulin polyglutamylase complex subunit 1 (PGs1) (p32).

CT152_HUMAN
θ value	0.00869519 (rank : 30)	NC score	0.340867 (rank : 12)
Query Neighborhood Hits	52	Target Neighborhood Hits	30	Shared Neighborhood Hits	28
SwissProt Accessions	Q96M20, Q5T3S1, Q9BR36, Q9BWY5	Gene names	C20orf152
Domain Architecture
Description	Uncharacterized protein C20orf152.

TPGS1_HUMAN
θ value	0.0148317 (rank : 31)	NC score	0.123858 (rank : 49)
Query Neighborhood Hits	52	Target Neighborhood Hits	10	Shared Neighborhood Hits	6
SwissProt Accessions	Q6ZTW0, Q96GE2	Gene names	C19orf20
Domain Architecture	No domain graphic available
Description	Tubulin polyglutamylase complex subunit 1 (PGs1).

CNGA3_HUMAN
θ value	0.0252991 (rank : 32)	NC score	0.254312 (rank : 27)
Query Neighborhood Hits	52	Target Neighborhood Hits	125	Shared Neighborhood Hits	38
SwissProt Accessions	Q16281, Q9UP64	Gene names	CNGA3, CNCG3
Domain Architecture
Description	Cyclic nucleotide-gated cation channel alpha 3 (CNG channel alpha 3) (CNG-3) (CNG3) (Cyclic nucleotide-gated channel alpha 3) (Cone photoreceptor cGMP-gated channel subunit alpha).

CNGA3_MOUSE
θ value	0.0252991 (rank : 33)	NC score	0.254763 (rank : 26)
Query Neighborhood Hits	52	Target Neighborhood Hits	84	Shared Neighborhood Hits	38
SwissProt Accessions	Q9JJZ8, Q9WV01	Gene names	Cnga3, Cng3
Domain Architecture
Description	Cyclic nucleotide-gated cation channel alpha 3 (CNG channel alpha 3) (CNG-3) (CNG3) (Cyclic nucleotide-gated channel alpha 3) (Cone photoreceptor cGMP-gated channel subunit alpha).

CNGB1_HUMAN
θ value	0.0961366 (rank : 34)	NC score	0.280490 (rank : 25)
Query Neighborhood Hits	52	Target Neighborhood Hits	222	Shared Neighborhood Hits	44
SwissProt Accessions	Q14028, Q14029	Gene names	CNGB1, CNCG4
Domain Architecture
Description	Cyclic nucleotide-gated cation channel 4 (CNG channel 4) (CNG-4) (CNG4) (Cyclic nucleotide-gated cation channel modulatory subunit).

KCNH7_HUMAN
θ value	0.0961366 (rank : 35)	NC score	0.168648 (rank : 36)
Query Neighborhood Hits	52	Target Neighborhood Hits	107	Shared Neighborhood Hits	33
SwissProt Accessions	Q9NS40	Gene names	KCNH7, ERG3
Domain Architecture
Description	Potassium voltage-gated channel subfamily H member 7 (Voltage-gated potassium channel subunit Kv11.3) (Ether-a-go-go-related gene potassium channel 3) (HERG-3) (Ether-a-go-go-related protein 3) (Eag- related protein 3).

CNGA1_HUMAN
θ value	0.125558 (rank : 36)	NC score	0.251726 (rank : 28)
Query Neighborhood Hits	52	Target Neighborhood Hits	149	Shared Neighborhood Hits	40
SwissProt Accessions	P29973, Q16279, Q16485	Gene names	CNGA1, CNCG, CNCG1
Domain Architecture
Description	cGMP-gated cation channel alpha 1 (CNG channel alpha 1) (CNG-1) (CNG1) (Cyclic nucleotide-gated channel alpha 1) (Cyclic nucleotide-gated channel, photoreceptor) (Cyclic nucleotide-gated cation channel 1) (Rod photoreceptor cGMP-gated channel subunit alpha).

CNGA1_MOUSE
θ value	0.125558 (rank : 37)	NC score	0.249528 (rank : 29)
Query Neighborhood Hits	52	Target Neighborhood Hits	198	Shared Neighborhood Hits	40
SwissProt Accessions	P29974, Q60776	Gene names	Cnga1, Cncg, Cncg1
Domain Architecture
Description	cGMP-gated cation channel alpha 1 (CNG channel alpha 1) (CNG-1) (CNG1) (Cyclic nucleotide-gated channel alpha 1) (Cyclic nucleotide-gated channel, photoreceptor) (Cyclic nucleotide-gated cation channel 1) (Rod photoreceptor cGMP-gated channel subunit alpha).

CNGA2_MOUSE
θ value	0.125558 (rank : 38)	NC score	0.244121 (rank : 30)
Query Neighborhood Hits	52	Target Neighborhood Hits	86	Shared Neighborhood Hits	38
SwissProt Accessions	Q62398	Gene names	Cnga2, Cncg2, Cncg4
Domain Architecture
Description	Cyclic nucleotide-gated olfactory channel (Cyclic nucleotide-gated cation channel 2) (CNG channel 2) (CNG-2) (CNG2).

KCNH7_MOUSE
θ value	0.47712 (rank : 39)	NC score	0.161846 (rank : 37)
Query Neighborhood Hits	52	Target Neighborhood Hits	98	Shared Neighborhood Hits	32
SwissProt Accessions	Q9ER47	Gene names	Kcnh7, Erg3
Domain Architecture
Description	Potassium voltage-gated channel subfamily H member 7 (Voltage-gated potassium channel subunit Kv11.3) (Ether-a-go-go-related gene potassium channel 3) (Ether-a-go-go-related protein 3) (Eag-related protein 3).

KCNH2_HUMAN
θ value	0.813845 (rank : 40)	NC score	0.156355 (rank : 39)
Query Neighborhood Hits	52	Target Neighborhood Hits	158	Shared Neighborhood Hits	32
SwissProt Accessions	Q12809, O75418, O75680, Q9BT72, Q9BUT7, Q9H3P0	Gene names	KCNH2, ERG, ERG1, HERG, HERG1
Domain Architecture
Description	Potassium voltage-gated channel subfamily H member 2 (Voltage-gated potassium channel subunit Kv11.1) (Ether-a-go-go-related gene potassium channel 1) (H-ERG) (Erg1) (Ether-a-go-go-related protein 1) (Eag-related protein 1) (eag homolog).

KCNH2_MOUSE
θ value	1.06291 (rank : 41)	NC score	0.156057 (rank : 40)
Query Neighborhood Hits	52	Target Neighborhood Hits	165	Shared Neighborhood Hits	32
SwissProt Accessions	O35219, O35220, O35221, O35989	Gene names	Kcnh2, Erg, Merg1
Domain Architecture
Description	Potassium voltage-gated channel subfamily H member 2 (Voltage-gated potassium channel subunit Kv11.1) (Ether-a-go-go-related gene potassium channel 1) (ERG1) (MERG) (Merg1) (Ether-a-go-go-related protein 1) (Eag-related protein 1).

KCNH1_HUMAN
θ value	1.38821 (rank : 42)	NC score	0.146407 (rank : 42)
Query Neighborhood Hits	52	Target Neighborhood Hits	98	Shared Neighborhood Hits	30
SwissProt Accessions	O95259, O76035	Gene names	KCNH1, EAG, EAG1
Domain Architecture
Description	Potassium voltage-gated channel subfamily H member 1 (Voltage-gated potassium channel subunit Kv10.1) (Ether-a-go-go potassium channel 1) (hEAG1) (h-eag).

KCNH1_MOUSE
θ value	1.38821 (rank : 43)	NC score	0.146465 (rank : 41)
Query Neighborhood Hits	52	Target Neighborhood Hits	94	Shared Neighborhood Hits	30
SwissProt Accessions	Q60603	Gene names	Kcnh1, Eag
Domain Architecture
Description	Potassium voltage-gated channel subfamily H member 1 (Voltage-gated potassium channel subunit Kv10.1) (Ether-a-go-go potassium channel 1) (EAG1) (m-eag).

AKAP8_HUMAN
θ value	2.36792 (rank : 44)	NC score	0.017233 (rank : 86)
Query Neighborhood Hits	52	Target Neighborhood Hits	166	Shared Neighborhood Hits	4
SwissProt Accessions	O43823	Gene names	AKAP8, AKAP95
Domain Architecture
Description	A-kinase anchor protein 8 (A-kinase anchor protein 95 kDa) (AKAP 95).

KCNH6_HUMAN
θ value	2.36792 (rank : 45)	NC score	0.157999 (rank : 38)
Query Neighborhood Hits	52	Target Neighborhood Hits	222	Shared Neighborhood Hits	34
SwissProt Accessions	Q9H252, Q9BRD7	Gene names	KCNH6, ERG2, HERG2
Domain Architecture
Description	Potassium voltage-gated channel subfamily H member 6 (Voltage-gated potassium channel subunit Kv11.2) (Ether-a-go-go-related gene potassium channel 2) (Ether-a-go-go-related protein 2) (Eag-related protein 2).

HRB2_HUMAN
θ value	3.0926 (rank : 46)	NC score	0.021565 (rank : 85)
Query Neighborhood Hits	52	Target Neighborhood Hits	41	Shared Neighborhood Hits	3
SwissProt Accessions	Q13601, Q8NEA8, Q8TC37, Q96AT5	Gene names	HRB2
Domain Architecture	No domain graphic available
Description	HIV-1 Rev-binding protein 2 (Rev-interacting protein 1) (Rip-1).

MYST3_HUMAN
θ value	6.88961 (rank : 47)	NC score	0.003687 (rank : 89)
Query Neighborhood Hits	52	Target Neighborhood Hits	772	Shared Neighborhood Hits	4
SwissProt Accessions	Q92794	Gene names	MYST3, MOZ, RUNXBP2, ZNF220
Domain Architecture
Description	Histone acetyltransferase MYST3 (EC 2.3.1.48) (EC 2.3.1.-) (MYST protein 3) (MOZ, YBF2/SAS3, SAS2 and TIP60 protein 3) (Runt-related transcription factor-binding protein 2) (Monocytic leukemia zinc finger protein) (Zinc finger protein 220).

RIMB1_HUMAN
θ value	6.88961 (rank : 48)	NC score	0.001640 (rank : 90)
Query Neighborhood Hits	52	Target Neighborhood Hits	1479	Shared Neighborhood Hits	6
SwissProt Accessions	O95153, O75111, Q8N5W3	Gene names	BZRAP1, KIAA0612, RBP1
Domain Architecture
Description	Peripheral-type benzodiazepine receptor-associated protein 1 (PRAX-1) (Peripheral benzodiazepine receptor-interacting protein) (PBR-IP) (RIM-binding protein 1) (RIM-BP1).

CB017_MOUSE
θ value	8.99809 (rank : 49)	NC score	0.008358 (rank : 88)
Query Neighborhood Hits	52	Target Neighborhood Hits	63	Shared Neighborhood Hits	2
SwissProt Accessions	Q6NS82, Q3TA48, Q8BSD3, Q8CHY1, Q8R0Q3	Gene names
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C2orf17 homolog.

CD3E_MOUSE
θ value	8.99809 (rank : 50)	NC score	0.010479 (rank : 87)
Query Neighborhood Hits	52	Target Neighborhood Hits	34	Shared Neighborhood Hits	2
SwissProt Accessions	P22646	Gene names	Cd3e
Domain Architecture
Description	T-cell surface glycoprotein CD3 epsilon chain precursor (T-cell surface antigen T3/Leu-4 epsilon chain).

CJ118_MOUSE
θ value	8.99809 (rank : 51)	NC score	-0.000294 (rank : 91)
Query Neighborhood Hits	52	Target Neighborhood Hits	1132	Shared Neighborhood Hits	5
SwissProt Accessions	Q8C9S4, Q6P3D6, Q8CJC0	Gene names	Otg1
Domain Architecture	No domain graphic available
Description	Protein C10orf118 homolog (Oocyte-testis gene 1 protein).

RPGF6_HUMAN
θ value	8.99809 (rank : 52)	NC score	0.101864 (rank : 52)
Query Neighborhood Hits	52	Target Neighborhood Hits	266	Shared Neighborhood Hits	16
SwissProt Accessions	Q8TEU7, Q8NI21, Q8TEU6, Q96PC1	Gene names	RAPGEF6, PDZGEF2
Domain Architecture
Description	Rap guanine nucleotide exchange factor 6 (PDZ domain-containing guanine nucleotide exchange factor 2) (PDZ-GEF2) (RA-GEF-2).

KAPCA_HUMAN
θ value	θ > 10 (rank : 53)	NC score	0.056230 (rank : 63)
Query Neighborhood Hits	52	Target Neighborhood Hits	838	Shared Neighborhood Hits	5
SwissProt Accessions	P17612, Q9H2Y0, Q9NRB4, Q9NRH9	Gene names	PRKACA, PKACA
Domain Architecture
Description	cAMP-dependent protein kinase, alpha-catalytic subunit (EC 2.7.11.11) (PKA C-alpha).

KAPCA_MOUSE
θ value	θ > 10 (rank : 54)	NC score	0.056582 (rank : 60)
Query Neighborhood Hits	52	Target Neighborhood Hits	836	Shared Neighborhood Hits	5
SwissProt Accessions	P05132, Q9JID0	Gene names	Prkaca, Pkaca
Domain Architecture
Description	cAMP-dependent protein kinase, alpha-catalytic subunit (EC 2.7.11.11) (PKA C-alpha).

KAPCB_HUMAN
θ value	θ > 10 (rank : 55)	NC score	0.056272 (rank : 62)
Query Neighborhood Hits	52	Target Neighborhood Hits	837	Shared Neighborhood Hits	5
SwissProt Accessions	P22694, Q59GC0, Q5BNE9, Q5BNF0, Q5BNF1, Q5BNF2, Q5BNF3, Q5CZ92, Q5T1K3, Q7Z3M1, Q8IYR5, Q8IZQ0	Gene names	PRKACB
Domain Architecture
Description	cAMP-dependent protein kinase, beta-catalytic subunit (EC 2.7.11.11) (PKA C-beta).

KAPCB_MOUSE
θ value	θ > 10 (rank : 56)	NC score	0.056451 (rank : 61)
Query Neighborhood Hits	52	Target Neighborhood Hits	836	Shared Neighborhood Hits	5
SwissProt Accessions	P68181, P05206, Q3TQH5, Q3UDD0, Q3UTH5	Gene names	Prkacb, Pkacb
Domain Architecture	No domain graphic available
Description	cAMP-dependent protein kinase, beta-catalytic subunit (EC 2.7.11.11) (PKA C-beta).

KAPCG_HUMAN
θ value	θ > 10 (rank : 57)	NC score	0.055018 (rank : 72)
Query Neighborhood Hits	52	Target Neighborhood Hits	845	Shared Neighborhood Hits	5
SwissProt Accessions	P22612, O60850, Q86YI1	Gene names	PRKACG
Domain Architecture
Description	cAMP-dependent protein kinase, gamma-catalytic subunit (EC 2.7.11.11) (PKA C-gamma).

KCNH3_HUMAN
θ value	θ > 10 (rank : 58)	NC score	0.126066 (rank : 48)
Query Neighborhood Hits	52	Target Neighborhood Hits	148	Shared Neighborhood Hits	26
SwissProt Accessions	Q9ULD8, Q9UQ06	Gene names	KCNH3, KIAA1282
Domain Architecture
Description	Potassium voltage-gated channel subfamily H member 3 (Voltage-gated potassium channel subunit Kv12.2) (Ether-a-go-go-like potassium channel 2) (ELK channel 2) (ELK2) (Brain-specific eag-like channel 1) (BEC1).

KCNH3_MOUSE
θ value	θ > 10 (rank : 59)	NC score	0.127812 (rank : 46)
Query Neighborhood Hits	52	Target Neighborhood Hits	133	Shared Neighborhood Hits	26
SwissProt Accessions	Q9WVJ0	Gene names	Kcnh3, Elk2
Domain Architecture
Description	Potassium voltage-gated channel subfamily H member 3 (Voltage-gated potassium channel subunit Kv12.2) (Ether-a-go-go-like potassium channel 2) (ELK channel 2) (mElk2).

KCNH4_HUMAN
θ value	θ > 10 (rank : 60)	NC score	0.126785 (rank : 47)
Query Neighborhood Hits	52	Target Neighborhood Hits	177	Shared Neighborhood Hits	26
SwissProt Accessions	Q9UQ05	Gene names	KCNH4
Domain Architecture
Description	Potassium voltage-gated channel subfamily H member 4 (Voltage-gated potassium channel subunit Kv12.3) (Ether-a-go-go-like potassium channel 1) (ELK channel 1) (ELK1) (Brain-specific eag-like channel 2) (BEC2).

KCNH5_HUMAN
θ value	θ > 10 (rank : 61)	NC score	0.130090 (rank : 44)
Query Neighborhood Hits	52	Target Neighborhood Hits	99	Shared Neighborhood Hits	26
SwissProt Accessions	Q8NCM2	Gene names	KCNH5, EAG2
Domain Architecture
Description	Potassium voltage-gated channel subfamily H member 5 (Voltage-gated potassium channel subunit Kv10.2) (Ether-a-go-go potassium channel 2) (hEAG2).

KCNH5_MOUSE
θ value	θ > 10 (rank : 62)	NC score	0.131827 (rank : 43)
Query Neighborhood Hits	52	Target Neighborhood Hits	102	Shared Neighborhood Hits	28
SwissProt Accessions	Q920E3, Q8C035	Gene names	Kcnh5, Eag2
Domain Architecture	No domain graphic available
Description	Potassium voltage-gated channel subfamily H member 5 (Voltage-gated potassium channel subunit Kv10.2) (Ether-a-go-go potassium channel 2) (Eag2).

KCNH8_HUMAN
θ value	θ > 10 (rank : 63)	NC score	0.128849 (rank : 45)
Query Neighborhood Hits	52	Target Neighborhood Hits	104	Shared Neighborhood Hits	28
SwissProt Accessions	Q96L42	Gene names	KCNH8
Domain Architecture
Description	Potassium voltage-gated channel subfamily H member 8 (Voltage-gated potassium channel subunit Kv12.1) (Ether-a-go-go-like potassium channel 3) (ELK channel 3) (ELK3) (ELK1) (hElk1).

KS6B1_HUMAN
θ value	θ > 10 (rank : 64)	NC score	0.050221 (rank : 82)
Query Neighborhood Hits	52	Target Neighborhood Hits	850	Shared Neighborhood Hits	6
SwissProt Accessions	P23443	Gene names	RPS6KB1
Domain Architecture
Description	Ribosomal protein S6 kinase beta-1 (EC 2.7.11.1) (Ribosomal protein S6 kinase I) (S6K) (S6K1) (70 kDa ribosomal protein S6 kinase 1) (p70 S6 kinase alpha) (p70(S6K)-alpha) (p70-S6K) (P70S6K) (p70-alpha).

KS6B1_MOUSE
θ value	θ > 10 (rank : 65)	NC score	0.050220 (rank : 83)
Query Neighborhood Hits	52	Target Neighborhood Hits	849	Shared Neighborhood Hits	6
SwissProt Accessions	Q8BSK8, Q8CHX0	Gene names	Rps6kb1
Domain Architecture	No domain graphic available
Description	Ribosomal protein S6 kinase beta-1 (EC 2.7.11.1) (Ribosomal protein S6 kinase I) (S6K) (S6K1) (70 kDa ribosomal protein S6 kinase 1) (p70 S6 kinase alpha) (p70(S6K)-alpha) (p70-S6K) (P70S6K).

KS6B2_HUMAN
θ value	θ > 10 (rank : 66)	NC score	0.051212 (rank : 80)
Query Neighborhood Hits	52	Target Neighborhood Hits	858	Shared Neighborhood Hits	5
SwissProt Accessions	Q9UBS0, O94809, Q9UEC1	Gene names	RPS6KB2, STK14B
Domain Architecture
Description	Ribosomal protein S6 kinase beta-2 (EC 2.7.11.1) (S6K2) (70 kDa ribosomal protein S6 kinase 2) (p70-S6KB) (p70 ribosomal S6 kinase beta) (p70 S6Kbeta) (p70 S6 kinase beta) (S6K-beta) (p70-beta) (S6 kinase-related kinase) (SRK) (Serine/threonine-protein kinase 14 beta).

KS6B2_MOUSE
θ value	θ > 10 (rank : 67)	NC score	0.051749 (rank : 79)
Query Neighborhood Hits	52	Target Neighborhood Hits	871	Shared Neighborhood Hits	5
SwissProt Accessions	Q9Z1M4	Gene names	Rps6kb2
Domain Architecture
Description	Ribosomal protein S6 kinase beta-2 (EC 2.7.11.1) (S6K-beta 2) (70 kDa ribosomal protein S6 kinase 2) (p70-S6KB) (p70 ribosomal S6 kinase beta) (p70 S6Kbeta) (S6K2).

KS6C1_HUMAN
θ value	θ > 10 (rank : 68)	NC score	0.053551 (rank : 76)
Query Neighborhood Hits	52	Target Neighborhood Hits	682	Shared Neighborhood Hits	5
SwissProt Accessions	Q96S38, Q8TDD3, Q9NSF4, Q9UL66	Gene names	RPS6KC1, RPK118
Domain Architecture	No domain graphic available
Description	Ribosomal protein S6 kinase delta-1 (EC 2.7.11.1) (52 kDa ribosomal protein S6 kinase) (Ribosomal S6 kinase-like protein with two PSK domains 118 kDa protein) (SPHK1-binding protein).

KS6C1_MOUSE
θ value	θ > 10 (rank : 69)	NC score	0.052292 (rank : 78)
Query Neighborhood Hits	52	Target Neighborhood Hits	700	Shared Neighborhood Hits	5
SwissProt Accessions	Q8BLK9, Q3UDY3, Q6PDY4, Q8BMQ5, Q8BX49	Gene names	Rps6kc1
Domain Architecture	No domain graphic available
Description	Ribosomal protein S6 kinase delta-1 (EC 2.7.11.1) (52 kDa ribosomal protein S6 kinase).

LATS1_HUMAN
θ value	θ > 10 (rank : 70)	NC score	0.055178 (rank : 69)
Query Neighborhood Hits	52	Target Neighborhood Hits	1057	Shared Neighborhood Hits	5
SwissProt Accessions	O95835, Q6PKD0	Gene names	LATS1, WARTS
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase LATS1 (EC 2.7.11.1) (Large tumor suppressor homolog 1) (WARTS protein kinase) (h-warts).

LATS1_MOUSE
θ value	θ > 10 (rank : 71)	NC score	0.055111 (rank : 70)
Query Neighborhood Hits	52	Target Neighborhood Hits	1027	Shared Neighborhood Hits	5
SwissProt Accessions	Q8BYR2, Q9Z0W4	Gene names	Lats1, Warts
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase LATS1 (EC 2.7.11.1) (Large tumor suppressor homolog 1) (WARTS protein kinase).

LATS2_HUMAN
θ value	θ > 10 (rank : 72)	NC score	0.056182 (rank : 64)
Query Neighborhood Hits	52	Target Neighborhood Hits	884	Shared Neighborhood Hits	5
SwissProt Accessions	Q9NRM7, Q9P2X1	Gene names	LATS2, KPM
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase LATS2 (EC 2.7.11.1) (Large tumor suppressor homolog 2) (Serine/threonine-protein kinase kpm) (Kinase phosphorylated during mitosis protein) (Warts-like kinase).

LATS2_MOUSE
θ value	θ > 10 (rank : 73)	NC score	0.055195 (rank : 68)
Query Neighborhood Hits	52	Target Neighborhood Hits	879	Shared Neighborhood Hits	5
SwissProt Accessions	Q7TSJ6, Q8CDJ4, Q9JMI3	Gene names	Lats2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase LATS2 (EC 2.7.11.1) (Large tumor suppressor homolog 2) (Serine/threonine-protein kinase kpm) (Kinase phosphorylated during mitosis protein).

PKN3_HUMAN
θ value	θ > 10 (rank : 74)	NC score	0.050370 (rank : 81)
Query Neighborhood Hits	52	Target Neighborhood Hits	893	Shared Neighborhood Hits	5
SwissProt Accessions	Q6P5Z2, Q9UM03	Gene names	PKN3, PKNBETA
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase N3 (EC 2.7.11.13) (Protein kinase PKN- beta) (Protein-kinase C-related kinase 3).

PKN3_MOUSE
θ value	θ > 10 (rank : 75)	NC score	0.050084 (rank : 84)
Query Neighborhood Hits	52	Target Neighborhood Hits	1009	Shared Neighborhood Hits	9
SwissProt Accessions	Q8K045	Gene names	Pkn3, Pknbeta
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase N3 (EC 2.7.11.13) (Protein kinase PKN- beta) (Protein-kinase C-related kinase 3).

PRKX_HUMAN
θ value	θ > 10 (rank : 76)	NC score	0.057636 (rank : 58)
Query Neighborhood Hits	52	Target Neighborhood Hits	847	Shared Neighborhood Hits	5
SwissProt Accessions	P51817	Gene names	PRKX, PKX1
Domain Architecture
Description	Serine/threonine-protein kinase PRKX (EC 2.7.11.1) (Protein kinase PKX1).

PRKX_MOUSE
θ value	θ > 10 (rank : 77)	NC score	0.057705 (rank : 57)
Query Neighborhood Hits	52	Target Neighborhood Hits	846	Shared Neighborhood Hits	5
SwissProt Accessions	Q922R0, Q3UCD1, Q8BHD6, Q9QZ12	Gene names	Prkx, Pkare
Domain Architecture
Description	Serine/threonine-protein kinase PRKX (EC 2.7.11.1) (PKA-related protein kinase).

PRKY_HUMAN
θ value	θ > 10 (rank : 78)	NC score	0.052923 (rank : 77)
Query Neighborhood Hits	52	Target Neighborhood Hits	844	Shared Neighborhood Hits	5
SwissProt Accessions	O43930, O15348, O15349	Gene names	PRKY
Domain Architecture
Description	Serine/threonine-protein kinase PRKY (EC 2.7.11.1).

RPGF1_HUMAN
θ value	θ > 10 (rank : 79)	NC score	0.053781 (rank : 74)
Query Neighborhood Hits	52	Target Neighborhood Hits	262	Shared Neighborhood Hits	6
SwissProt Accessions	Q13905	Gene names	RAPGEF1, GRF2
Domain Architecture
Description	Rap guanine nucleotide exchange factor 1 (Guanine nucleotide-releasing factor 2) (C3G protein) (CRK SH3-binding GNRP).

RPGF2_HUMAN
θ value	θ > 10 (rank : 80)	NC score	0.063512 (rank : 56)
Query Neighborhood Hits	52	Target Neighborhood Hits	242	Shared Neighborhood Hits	11
SwissProt Accessions	Q9Y4G8	Gene names	RAPGEF2, KIAA0313, NRAPGEP, PDZGEF1
Domain Architecture	No domain graphic available
Description	Rap guanine nucleotide exchange factor 2 (Neural RAP guanine nucleotide exchange protein) (nRap GEP) (PDZ domain-containing guanine nucleotide exchange factor 1) (PDZ-GEF1) (RA-GEF).

RPGF5_HUMAN
θ value	θ > 10 (rank : 81)	NC score	0.090718 (rank : 55)
Query Neighborhood Hits	52	Target Neighborhood Hits	42	Shared Neighborhood Hits	5
SwissProt Accessions	Q92565, Q8IXU5	Gene names	RAPGEF5, GFR, KIAA0277, MRGEF
Domain Architecture
Description	Rap guanine nucleotide exchange factor 5 (Guanine nucleotide exchange factor for Rap1) (Related to Epac) (Repac) (M-Ras-regulated Rap GEF) (MR-GEF).

RPGF5_MOUSE
θ value	θ > 10 (rank : 82)	NC score	0.092497 (rank : 54)
Query Neighborhood Hits	52	Target Neighborhood Hits	85	Shared Neighborhood Hits	5
SwissProt Accessions	Q8C0Q9, Q8BJJ9, Q8C0R5	Gene names	Rapgef5, Gfr, Kiaa0277, Mrgef
Domain Architecture
Description	Rap guanine nucleotide exchange factor 5 (Guanine nucleotide exchange factor for Rap1) (M-Ras-regulated Rap GEF) (MR-GEF).

RPKL1_HUMAN
θ value	θ > 10 (rank : 83)	NC score	0.055066 (rank : 71)
Query Neighborhood Hits	52	Target Neighborhood Hits	708	Shared Neighborhood Hits	7
SwissProt Accessions	Q9Y6S9, Q69YT9, Q6ZMQ6, Q96NR9, Q9BSU9	Gene names	RPS6KL1
Domain Architecture	No domain graphic available
Description	Ribosomal protein S6 kinase-like 1 (EC 2.7.11.1).

SCYL2_HUMAN
θ value	θ > 10 (rank : 84)	NC score	0.053748 (rank : 75)
Query Neighborhood Hits	52	Target Neighborhood Hits	632	Shared Neighborhood Hits	5
SwissProt Accessions	Q6P3W7, Q96EF4, Q96ST4, Q9H7V5, Q9NVH3, Q9P2I7	Gene names	SCYL2, CVAK104, KIAA1360
Domain Architecture	No domain graphic available
Description	SCY1-like protein 2 (Coated vesicle-associated kinase of 104 kDa).

SCYL2_MOUSE
θ value	θ > 10 (rank : 85)	NC score	0.054218 (rank : 73)
Query Neighborhood Hits	52	Target Neighborhood Hits	603	Shared Neighborhood Hits	6
SwissProt Accessions	Q8CFE4, Q3UT57, Q3UWU9, Q8K0M4	Gene names	Scyl2, Cvak104, D10Ertd802e
Domain Architecture	No domain graphic available
Description	SCY1-like protein 2 (Coated vesicle-associated kinase of 104 kDa).

SP17_HUMAN
θ value	θ > 10 (rank : 86)	NC score	0.093655 (rank : 53)
Query Neighborhood Hits	52	Target Neighborhood Hits	34	Shared Neighborhood Hits	4
SwissProt Accessions	Q15506, Q9BXF7	Gene names	SPA17, SP17
Domain Architecture
Description	Sperm surface protein Sp17 (Sperm autoantigenic protein 17) (Sperm protein 17) (Sp17-1).

SP17_MOUSE
θ value	θ > 10 (rank : 87)	NC score	0.102680 (rank : 51)
Query Neighborhood Hits	52	Target Neighborhood Hits	24	Shared Neighborhood Hits	4
SwissProt Accessions	Q62252	Gene names	Spa17, Sp17
Domain Architecture
Description	Sperm surface protein Sp17 (Sperm autoantigenic protein 17).

ST38L_HUMAN
θ value	θ > 10 (rank : 88)	NC score	0.056154 (rank : 65)
Query Neighborhood Hits	52	Target Neighborhood Hits	824	Shared Neighborhood Hits	5
SwissProt Accessions	Q9Y2H1, Q8TBX7	Gene names	STK38L, KIAA0965, NDR2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 38-like (EC 2.7.11.1) (NDR2 protein kinase) (Nuclear Dbf2-related kinase 2).

ST38L_MOUSE
θ value	θ > 10 (rank : 89)	NC score	0.056920 (rank : 59)
Query Neighborhood Hits	52	Target Neighborhood Hits	821	Shared Neighborhood Hits	5
SwissProt Accessions	Q7TSE6, Q6P6K6, Q8BWK4	Gene names	Stk38l, Ndr2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 38-like (EC 2.7.11.1) (NDR2 protein kinase) (Nuclear Dbf2-related kinase 2).

STK38_HUMAN
θ value	θ > 10 (rank : 90)	NC score	0.056016 (rank : 66)
Query Neighborhood Hits	52	Target Neighborhood Hits	840	Shared Neighborhood Hits	5
SwissProt Accessions	Q15208	Gene names	STK38, NDR1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 38 (EC 2.7.11.1) (NDR1 protein kinase) (Nuclear Dbf2-related kinase 1).

STK38_MOUSE
θ value	θ > 10 (rank : 91)	NC score	0.055896 (rank : 67)
Query Neighborhood Hits	52	Target Neighborhood Hits	838	Shared Neighborhood Hits	5
SwissProt Accessions	Q91VJ4	Gene names	Stk38, Ndr1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 38 (EC 2.7.11.1) (NDR1 protein kinase) (Nuclear Dbf2-related kinase 1).

Hits sorted by NC score

KAP0_HUMAN
NC score	0.999962 (rank : 1)	θ value	0 (rank : 1)
Query Neighborhood Hits	52	Target Neighborhood Hits	52	Shared Neighborhood Hits	52
SwissProt Accessions	P10644, Q567S7	Gene names	PRKAR1A, PKR1, PRKAR1
Domain Architecture
Description	cAMP-dependent protein kinase type I-alpha regulatory subunit (Tissue- specific extinguisher 1) (TSE1).

KAP0_MOUSE
NC score	0.997859 (rank : 2)	θ value	0 (rank : 2)
Query Neighborhood Hits	52	Target Neighborhood Hits	48	Shared Neighborhood Hits	47
SwissProt Accessions	Q9DBC7, Q3UKU7, Q9JHR5, Q9JHR6	Gene names	Prkar1a
Domain Architecture	No domain graphic available
Description	cAMP-dependent protein kinase type I-alpha regulatory subunit.

KAP1_MOUSE
NC score	0.994458 (rank : 3)	θ value	1.27474e-179 (rank : 4)
Query Neighborhood Hits	52	Target Neighborhood Hits	49	Shared Neighborhood Hits	42
SwissProt Accessions	P12849	Gene names	Prkar1b
Domain Architecture
Description	cAMP-dependent protein kinase type I-beta regulatory subunit.

KAP1_HUMAN
NC score	0.992537 (rank : 4)	θ value	1.27474e-179 (rank : 3)
Query Neighborhood Hits	52	Target Neighborhood Hits	58	Shared Neighborhood Hits	42
SwissProt Accessions	P31321	Gene names	PRKAR1B
Domain Architecture
Description	cAMP-dependent protein kinase type I-beta regulatory subunit.

KAP2_MOUSE
NC score	0.935614 (rank : 5)	θ value	1.31987e-59 (rank : 8)
Query Neighborhood Hits	52	Target Neighborhood Hits	44	Shared Neighborhood Hits	33
SwissProt Accessions	P12367	Gene names	Prkar2a
Domain Architecture
Description	cAMP-dependent protein kinase type II-alpha regulatory subunit.

KAP2_HUMAN
NC score	0.933480 (rank : 6)	θ value	2.84138e-62 (rank : 5)
Query Neighborhood Hits	52	Target Neighborhood Hits	48	Shared Neighborhood Hits	34
SwissProt Accessions	P13861, Q16823	Gene names	PRKAR2A, PKR2, PRKAR2
Domain Architecture
Description	cAMP-dependent protein kinase type II-alpha regulatory subunit.

KAP3_MOUSE
NC score	0.933016 (rank : 7)	θ value	3.47335e-60 (rank : 7)
Query Neighborhood Hits	52	Target Neighborhood Hits	43	Shared Neighborhood Hits	35
SwissProt Accessions	P31324, Q3UTZ1, Q80ZM4, Q8BRZ7	Gene names	Prkar2b
Domain Architecture	No domain graphic available
Description	cAMP-dependent protein kinase type II-beta regulatory subunit.

KAP3_HUMAN
NC score	0.932957 (rank : 8)	θ value	6.99855e-61 (rank : 6)
Query Neighborhood Hits	52	Target Neighborhood Hits	40	Shared Neighborhood Hits	35
SwissProt Accessions	P31323	Gene names	PRKAR2B
Domain Architecture
Description	cAMP-dependent protein kinase type II-beta regulatory subunit.

CT152_MOUSE
NC score	0.444008 (rank : 9)	θ value	0.000121331 (rank : 26)
Query Neighborhood Hits	52	Target Neighborhood Hits	38	Shared Neighborhood Hits	36
SwissProt Accessions	Q9D5U8, Q8R083	Gene names
Domain Architecture
Description	Uncharacterized protein C20orf152 homolog.

RPGF3_MOUSE
NC score	0.346980 (rank : 10)	θ value	3.41135e-07 (rank : 14)
Query Neighborhood Hits	52	Target Neighborhood Hits	54	Shared Neighborhood Hits	26
SwissProt Accessions	Q8VCC8, Q8BZK9, Q8R1R1	Gene names	Rapgef3, Epac, Epac1
Domain Architecture
Description	Rap guanine nucleotide exchange factor 3 (cAMP-regulated guanine nucleotide exchange factor I) (cAMP-GEFI) (Exchange factor directly activated by cAMP 1) (Epac 1).

RPGF3_HUMAN
NC score	0.344202 (rank : 11)	θ value	4.45536e-07 (rank : 15)
Query Neighborhood Hits	52	Target Neighborhood Hits	56	Shared Neighborhood Hits	26
SwissProt Accessions	O95398, O95634, Q8WVN0	Gene names	RAPGEF3, CGEF1, EPAC, EPAC1
Domain Architecture
Description	Rap guanine nucleotide exchange factor 3 (cAMP-regulated guanine nucleotide exchange factor I) (cAMP-GEFI) (Exchange factor directly activated by cAMP 1) (Epac 1) (Rap1 guanine-nucleotide-exchange factor directly activated by cAMP).

CT152_HUMAN
NC score	0.340867 (rank : 12)	θ value	0.00869519 (rank : 30)
Query Neighborhood Hits	52	Target Neighborhood Hits	30	Shared Neighborhood Hits	28
SwissProt Accessions	Q96M20, Q5T3S1, Q9BR36, Q9BWY5	Gene names	C20orf152
Domain Architecture
Description	Uncharacterized protein C20orf152.

HCN2_MOUSE
NC score	0.328084 (rank : 13)	θ value	1.09739e-05 (rank : 21)
Query Neighborhood Hits	52	Target Neighborhood Hits	278	Shared Neighborhood Hits	39
SwissProt Accessions	O88703, O70506	Gene names	Hcn2, Bcng2, Hac1
Domain Architecture
Description	Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 (Brain cyclic nucleotide-gated channel 2) (BCNG-2) (Hyperpolarization-activated cation channel 1) (HAC-1).

HCN2_HUMAN
NC score	0.324662 (rank : 14)	θ value	1.09739e-05 (rank : 20)
Query Neighborhood Hits	52	Target Neighborhood Hits	369	Shared Neighborhood Hits	40
SwissProt Accessions	Q9UL51, O60742, O60743, O75267, Q9UBS2	Gene names	HCN2, BCNG2
Domain Architecture
Description	Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 (Brain cyclic nucleotide-gated channel 2) (BCNG-2).

HCN4_MOUSE
NC score	0.324588 (rank : 15)	θ value	9.92553e-07 (rank : 18)
Query Neighborhood Hits	52	Target Neighborhood Hits	284	Shared Neighborhood Hits	38
SwissProt Accessions	O70507	Gene names	Hcn4, Bcng3
Domain Architecture
Description	Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 (Brain cyclic nucleotide-gated channel 3) (BCNG-3).

RPGF4_HUMAN
NC score	0.324242 (rank : 16)	θ value	5.81887e-07 (rank : 16)
Query Neighborhood Hits	52	Target Neighborhood Hits	88	Shared Neighborhood Hits	31
SwissProt Accessions	Q8WZA2, O95636, Q8IXK6, Q8TAA4	Gene names	RAPGEF4, CGEF2, EPAC2
Domain Architecture
Description	Rap guanine nucleotide exchange factor 4 (cAMP-regulated guanine nucleotide exchange factor II) (cAMP-GEFII) (Exchange factor directly activated by cAMP 2) (Epac 2).

RPGF4_MOUSE
NC score	0.323355 (rank : 17)	θ value	7.59969e-07 (rank : 17)
Query Neighborhood Hits	52	Target Neighborhood Hits	80	Shared Neighborhood Hits	31
SwissProt Accessions	Q9EQZ6, Q8VIP9, Q9CW52, Q9Z1P0	Gene names	Rapgef4, Cgef2, Epac2
Domain Architecture
Description	Rap guanine nucleotide exchange factor 4 (cAMP-regulated guanine nucleotide exchange factor II) (cAMP-GEFII) (Exchange factor directly activated by cAMP 2) (Epac 2) (cAMP-dependent Rap1 guanine-nucleotide exchange factor).

HCN4_HUMAN
NC score	0.318480 (rank : 18)	θ value	1.29631e-06 (rank : 19)
Query Neighborhood Hits	52	Target Neighborhood Hits	303	Shared Neighborhood Hits	38
SwissProt Accessions	Q9Y3Q4, Q9UMQ7	Gene names	HCN4
Domain Architecture
Description	Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4.

HCN3_MOUSE
NC score	0.301688 (rank : 19)	θ value	1.09739e-05 (rank : 23)
Query Neighborhood Hits	52	Target Neighborhood Hits	112	Shared Neighborhood Hits	38
SwissProt Accessions	O88705	Gene names	Hcn3, Hac3
Domain Architecture
Description	Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 3 (Hyperpolarization-activated cation channel 3) (HAC-3).

HCN1_HUMAN
NC score	0.301563 (rank : 20)	θ value	1.87187e-05 (rank : 24)
Query Neighborhood Hits	52	Target Neighborhood Hits	120	Shared Neighborhood Hits	37
SwissProt Accessions	O60741	Gene names	HCN1, BCNG1
Domain Architecture
Description	Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1 (Brain cyclic nucleotide-gated channel 1) (BCNG-1).

HCN3_HUMAN
NC score	0.301109 (rank : 21)	θ value	1.09739e-05 (rank : 22)
Query Neighborhood Hits	52	Target Neighborhood Hits	99	Shared Neighborhood Hits	37
SwissProt Accessions	Q9P1Z3, Q4VX12, Q8N6W6, Q9BWQ2	Gene names	HCN3, KIAA1535
Domain Architecture
Description	Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 3.

HCN1_MOUSE
NC score	0.299784 (rank : 22)	θ value	1.87187e-05 (rank : 25)
Query Neighborhood Hits	52	Target Neighborhood Hits	172	Shared Neighborhood Hits	38
SwissProt Accessions	O88704, O54899, Q9D613	Gene names	Hcn1, Bcng1, Hac2
Domain Architecture
Description	Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1 (Brain cyclic nucleotide-gated channel 1) (BCNG-1) (Hyperpolarization-activated cation channel 2) (HAC-2).

CNGB3_MOUSE
NC score	0.294649 (rank : 23)	θ value	0.00134147 (rank : 27)
Query Neighborhood Hits	52	Target Neighborhood Hits	74	Shared Neighborhood Hits	41
SwissProt Accessions	Q9JJZ9	Gene names	Cngb3, Cng6
Domain Architecture
Description	Cyclic nucleotide-gated cation channel beta 3 (CNG channel beta 3) (Cyclic nucleotide-gated channel beta 3) (Cone photoreceptor cGMP- gated channel subunit beta) (Cyclic nucleotide-gated cation channel modulatory subunit) (Cyclic nucleotide-gated channel subunit CNG6).

CNGB3_HUMAN
NC score	0.293089 (rank : 24)	θ value	0.00228821 (rank : 28)
Query Neighborhood Hits	52	Target Neighborhood Hits	206	Shared Neighborhood Hits	40
SwissProt Accessions	Q9NQW8, Q9NRE9	Gene names	CNGB3
Domain Architecture
Description	Cyclic nucleotide-gated cation channel beta 3 (CNG channel beta 3) (Cyclic nucleotide-gated channel beta 3) (Cone photoreceptor cGMP- gated channel subunit beta) (Cyclic nucleotide-gated cation channel modulatory subunit).

CNGB1_HUMAN
NC score	0.280490 (rank : 25)	θ value	0.0961366 (rank : 34)
Query Neighborhood Hits	52	Target Neighborhood Hits	222	Shared Neighborhood Hits	44
SwissProt Accessions	Q14028, Q14029	Gene names	CNGB1, CNCG4
Domain Architecture
Description	Cyclic nucleotide-gated cation channel 4 (CNG channel 4) (CNG-4) (CNG4) (Cyclic nucleotide-gated cation channel modulatory subunit).

CNGA3_MOUSE
NC score	0.254763 (rank : 26)	θ value	0.0252991 (rank : 33)
Query Neighborhood Hits	52	Target Neighborhood Hits	84	Shared Neighborhood Hits	38
SwissProt Accessions	Q9JJZ8, Q9WV01	Gene names	Cnga3, Cng3
Domain Architecture
Description	Cyclic nucleotide-gated cation channel alpha 3 (CNG channel alpha 3) (CNG-3) (CNG3) (Cyclic nucleotide-gated channel alpha 3) (Cone photoreceptor cGMP-gated channel subunit alpha).

CNGA3_HUMAN
NC score	0.254312 (rank : 27)	θ value	0.0252991 (rank : 32)
Query Neighborhood Hits	52	Target Neighborhood Hits	125	Shared Neighborhood Hits	38
SwissProt Accessions	Q16281, Q9UP64	Gene names	CNGA3, CNCG3
Domain Architecture
Description	Cyclic nucleotide-gated cation channel alpha 3 (CNG channel alpha 3) (CNG-3) (CNG3) (Cyclic nucleotide-gated channel alpha 3) (Cone photoreceptor cGMP-gated channel subunit alpha).

CNGA1_HUMAN
NC score	0.251726 (rank : 28)	θ value	0.125558 (rank : 36)
Query Neighborhood Hits	52	Target Neighborhood Hits	149	Shared Neighborhood Hits	40
SwissProt Accessions	P29973, Q16279, Q16485	Gene names	CNGA1, CNCG, CNCG1
Domain Architecture
Description	cGMP-gated cation channel alpha 1 (CNG channel alpha 1) (CNG-1) (CNG1) (Cyclic nucleotide-gated channel alpha 1) (Cyclic nucleotide-gated channel, photoreceptor) (Cyclic nucleotide-gated cation channel 1) (Rod photoreceptor cGMP-gated channel subunit alpha).

CNGA1_MOUSE
NC score	0.249528 (rank : 29)	θ value	0.125558 (rank : 37)
Query Neighborhood Hits	52	Target Neighborhood Hits	198	Shared Neighborhood Hits	40
SwissProt Accessions	P29974, Q60776	Gene names	Cnga1, Cncg, Cncg1
Domain Architecture
Description	cGMP-gated cation channel alpha 1 (CNG channel alpha 1) (CNG-1) (CNG1) (Cyclic nucleotide-gated channel alpha 1) (Cyclic nucleotide-gated channel, photoreceptor) (Cyclic nucleotide-gated cation channel 1) (Rod photoreceptor cGMP-gated channel subunit alpha).

CNGA2_MOUSE
NC score	0.244121 (rank : 30)	θ value	0.125558 (rank : 38)
Query Neighborhood Hits	52	Target Neighborhood Hits	86	Shared Neighborhood Hits	38
SwissProt Accessions	Q62398	Gene names	Cnga2, Cncg2, Cncg4
Domain Architecture
Description	Cyclic nucleotide-gated olfactory channel (Cyclic nucleotide-gated cation channel 2) (CNG channel 2) (CNG-2) (CNG2).

KGP1B_HUMAN
NC score	0.227799 (rank : 31)	θ value	2.11701e-41 (rank : 9)
Query Neighborhood Hits	52	Target Neighborhood Hits	921	Shared Neighborhood Hits	42
SwissProt Accessions	P14619	Gene names	PRKG1, PRKG1B, PRKGR1B
Domain Architecture
Description	cGMP-dependent protein kinase 1, beta isozyme (EC 2.7.11.12) (cGK 1 beta) (cGKI-beta).

KGP1B_MOUSE
NC score	0.227281 (rank : 32)	θ value	4.71619e-41 (rank : 10)
Query Neighborhood Hits	52	Target Neighborhood Hits	922	Shared Neighborhood Hits	42
SwissProt Accessions	Q9Z0Z0	Gene names	Prkg1, Prkg1b, Prkgr1b
Domain Architecture
Description	cGMP-dependent protein kinase 1, beta isozyme (EC 2.7.11.12) (cGK 1 beta) (cGKI-beta).

KGP1A_HUMAN
NC score	0.226282 (rank : 33)	θ value	5.21438e-40 (rank : 11)
Query Neighborhood Hits	52	Target Neighborhood Hits	901	Shared Neighborhood Hits	42
SwissProt Accessions	Q13976	Gene names	PRKG1, PRKGR1A
Domain Architecture
Description	cGMP-dependent protein kinase 1, alpha isozyme (EC 2.7.11.12) (CGK 1 alpha) (cGKI-alpha).

KGP2_MOUSE
NC score	0.223720 (rank : 34)	θ value	6.59618e-35 (rank : 13)
Query Neighborhood Hits	52	Target Neighborhood Hits	1029	Shared Neighborhood Hits	38
SwissProt Accessions	Q61410	Gene names	Prkg2, Prkgr2
Domain Architecture
Description	cGMP-dependent protein kinase 2 (EC 2.7.11.12) (CGK 2) (cGKII) (Type II cGMP-dependent protein kinase).

KGP2_HUMAN
NC score	0.223135 (rank : 35)	θ value	3.86705e-35 (rank : 12)
Query Neighborhood Hits	52	Target Neighborhood Hits	1023	Shared Neighborhood Hits	39
SwissProt Accessions	Q13237, O00125, O60916	Gene names	PRKG2, PRKGR2
Domain Architecture
Description	cGMP-dependent protein kinase 2 (EC 2.7.11.12) (CGK 2) (cGKII) (Type II cGMP-dependent protein kinase).

KCNH7_HUMAN
NC score	0.168648 (rank : 36)	θ value	0.0961366 (rank : 35)
Query Neighborhood Hits	52	Target Neighborhood Hits	107	Shared Neighborhood Hits	33
SwissProt Accessions	Q9NS40	Gene names	KCNH7, ERG3
Domain Architecture
Description	Potassium voltage-gated channel subfamily H member 7 (Voltage-gated potassium channel subunit Kv11.3) (Ether-a-go-go-related gene potassium channel 3) (HERG-3) (Ether-a-go-go-related protein 3) (Eag- related protein 3).

KCNH7_MOUSE
NC score	0.161846 (rank : 37)	θ value	0.47712 (rank : 39)
Query Neighborhood Hits	52	Target Neighborhood Hits	98	Shared Neighborhood Hits	32
SwissProt Accessions	Q9ER47	Gene names	Kcnh7, Erg3
Domain Architecture
Description	Potassium voltage-gated channel subfamily H member 7 (Voltage-gated potassium channel subunit Kv11.3) (Ether-a-go-go-related gene potassium channel 3) (Ether-a-go-go-related protein 3) (Eag-related protein 3).

KCNH6_HUMAN
NC score	0.157999 (rank : 38)	θ value	2.36792 (rank : 45)
Query Neighborhood Hits	52	Target Neighborhood Hits	222	Shared Neighborhood Hits	34
SwissProt Accessions	Q9H252, Q9BRD7	Gene names	KCNH6, ERG2, HERG2
Domain Architecture
Description	Potassium voltage-gated channel subfamily H member 6 (Voltage-gated potassium channel subunit Kv11.2) (Ether-a-go-go-related gene potassium channel 2) (Ether-a-go-go-related protein 2) (Eag-related protein 2).

KCNH2_HUMAN
NC score	0.156355 (rank : 39)	θ value	0.813845 (rank : 40)
Query Neighborhood Hits	52	Target Neighborhood Hits	158	Shared Neighborhood Hits	32
SwissProt Accessions	Q12809, O75418, O75680, Q9BT72, Q9BUT7, Q9H3P0	Gene names	KCNH2, ERG, ERG1, HERG, HERG1
Domain Architecture
Description	Potassium voltage-gated channel subfamily H member 2 (Voltage-gated potassium channel subunit Kv11.1) (Ether-a-go-go-related gene potassium channel 1) (H-ERG) (Erg1) (Ether-a-go-go-related protein 1) (Eag-related protein 1) (eag homolog).

KCNH2_MOUSE
NC score	0.156057 (rank : 40)	θ value	1.06291 (rank : 41)
Query Neighborhood Hits	52	Target Neighborhood Hits	165	Shared Neighborhood Hits	32
SwissProt Accessions	O35219, O35220, O35221, O35989	Gene names	Kcnh2, Erg, Merg1
Domain Architecture
Description	Potassium voltage-gated channel subfamily H member 2 (Voltage-gated potassium channel subunit Kv11.1) (Ether-a-go-go-related gene potassium channel 1) (ERG1) (MERG) (Merg1) (Ether-a-go-go-related protein 1) (Eag-related protein 1).

KCNH1_MOUSE
NC score	0.146465 (rank : 41)	θ value	1.38821 (rank : 43)
Query Neighborhood Hits	52	Target Neighborhood Hits	94	Shared Neighborhood Hits	30
SwissProt Accessions	Q60603	Gene names	Kcnh1, Eag
Domain Architecture
Description	Potassium voltage-gated channel subfamily H member 1 (Voltage-gated potassium channel subunit Kv10.1) (Ether-a-go-go potassium channel 1) (EAG1) (m-eag).

KCNH1_HUMAN
NC score	0.146407 (rank : 42)	θ value	1.38821 (rank : 42)
Query Neighborhood Hits	52	Target Neighborhood Hits	98	Shared Neighborhood Hits	30
SwissProt Accessions	O95259, O76035	Gene names	KCNH1, EAG, EAG1
Domain Architecture
Description	Potassium voltage-gated channel subfamily H member 1 (Voltage-gated potassium channel subunit Kv10.1) (Ether-a-go-go potassium channel 1) (hEAG1) (h-eag).

KCNH5_MOUSE
NC score	0.131827 (rank : 43)	θ value	θ > 10 (rank : 62)
Query Neighborhood Hits	52	Target Neighborhood Hits	102	Shared Neighborhood Hits	28
SwissProt Accessions	Q920E3, Q8C035	Gene names	Kcnh5, Eag2
Domain Architecture	No domain graphic available
Description	Potassium voltage-gated channel subfamily H member 5 (Voltage-gated potassium channel subunit Kv10.2) (Ether-a-go-go potassium channel 2) (Eag2).

KCNH5_HUMAN
NC score	0.130090 (rank : 44)	θ value	θ > 10 (rank : 61)
Query Neighborhood Hits	52	Target Neighborhood Hits	99	Shared Neighborhood Hits	26
SwissProt Accessions	Q8NCM2	Gene names	KCNH5, EAG2
Domain Architecture
Description	Potassium voltage-gated channel subfamily H member 5 (Voltage-gated potassium channel subunit Kv10.2) (Ether-a-go-go potassium channel 2) (hEAG2).

KCNH8_HUMAN
NC score	0.128849 (rank : 45)	θ value	θ > 10 (rank : 63)
Query Neighborhood Hits	52	Target Neighborhood Hits	104	Shared Neighborhood Hits	28
SwissProt Accessions	Q96L42	Gene names	KCNH8
Domain Architecture
Description	Potassium voltage-gated channel subfamily H member 8 (Voltage-gated potassium channel subunit Kv12.1) (Ether-a-go-go-like potassium channel 3) (ELK channel 3) (ELK3) (ELK1) (hElk1).

KCNH3_MOUSE
NC score	0.127812 (rank : 46)	θ value	θ > 10 (rank : 59)
Query Neighborhood Hits	52	Target Neighborhood Hits	133	Shared Neighborhood Hits	26
SwissProt Accessions	Q9WVJ0	Gene names	Kcnh3, Elk2
Domain Architecture
Description	Potassium voltage-gated channel subfamily H member 3 (Voltage-gated potassium channel subunit Kv12.2) (Ether-a-go-go-like potassium channel 2) (ELK channel 2) (mElk2).

KCNH4_HUMAN
NC score	0.126785 (rank : 47)	θ value	θ > 10 (rank : 60)
Query Neighborhood Hits	52	Target Neighborhood Hits	177	Shared Neighborhood Hits	26
SwissProt Accessions	Q9UQ05	Gene names	KCNH4
Domain Architecture
Description	Potassium voltage-gated channel subfamily H member 4 (Voltage-gated potassium channel subunit Kv12.3) (Ether-a-go-go-like potassium channel 1) (ELK channel 1) (ELK1) (Brain-specific eag-like channel 2) (BEC2).

KCNH3_HUMAN
NC score	0.126066 (rank : 48)	θ value	θ > 10 (rank : 58)
Query Neighborhood Hits	52	Target Neighborhood Hits	148	Shared Neighborhood Hits	26
SwissProt Accessions	Q9ULD8, Q9UQ06	Gene names	KCNH3, KIAA1282
Domain Architecture
Description	Potassium voltage-gated channel subfamily H member 3 (Voltage-gated potassium channel subunit Kv12.2) (Ether-a-go-go-like potassium channel 2) (ELK channel 2) (ELK2) (Brain-specific eag-like channel 1) (BEC1).

TPGS1_HUMAN
NC score	0.123858 (rank : 49)	θ value	0.0148317 (rank : 31)
Query Neighborhood Hits	52	Target Neighborhood Hits	10	Shared Neighborhood Hits	6
SwissProt Accessions	Q6ZTW0, Q96GE2	Gene names	C19orf20
Domain Architecture	No domain graphic available
Description	Tubulin polyglutamylase complex subunit 1 (PGs1).

TPGS1_MOUSE
NC score	0.106924 (rank : 50)	θ value	0.00509761 (rank : 29)
Query Neighborhood Hits	52	Target Neighborhood Hits	5	Shared Neighborhood Hits	4
SwissProt Accessions	Q99MS8, Q3U5Q9, Q9R0B5	Gene names	Gtrgeo22
Domain Architecture	No domain graphic available
Description	Tubulin polyglutamylase complex subunit 1 (PGs1) (p32).

SP17_MOUSE
NC score	0.102680 (rank : 51)	θ value	θ > 10 (rank : 87)
Query Neighborhood Hits	52	Target Neighborhood Hits	24	Shared Neighborhood Hits	4
SwissProt Accessions	Q62252	Gene names	Spa17, Sp17
Domain Architecture
Description	Sperm surface protein Sp17 (Sperm autoantigenic protein 17).

RPGF6_HUMAN
NC score	0.101864 (rank : 52)	θ value	8.99809 (rank : 52)
Query Neighborhood Hits	52	Target Neighborhood Hits	266	Shared Neighborhood Hits	16
SwissProt Accessions	Q8TEU7, Q8NI21, Q8TEU6, Q96PC1	Gene names	RAPGEF6, PDZGEF2
Domain Architecture
Description	Rap guanine nucleotide exchange factor 6 (PDZ domain-containing guanine nucleotide exchange factor 2) (PDZ-GEF2) (RA-GEF-2).

SP17_HUMAN
NC score	0.093655 (rank : 53)	θ value	θ > 10 (rank : 86)
Query Neighborhood Hits	52	Target Neighborhood Hits	34	Shared Neighborhood Hits	4
SwissProt Accessions	Q15506, Q9BXF7	Gene names	SPA17, SP17
Domain Architecture
Description	Sperm surface protein Sp17 (Sperm autoantigenic protein 17) (Sperm protein 17) (Sp17-1).

RPGF5_MOUSE
NC score	0.092497 (rank : 54)	θ value	θ > 10 (rank : 82)
Query Neighborhood Hits	52	Target Neighborhood Hits	85	Shared Neighborhood Hits	5
SwissProt Accessions	Q8C0Q9, Q8BJJ9, Q8C0R5	Gene names	Rapgef5, Gfr, Kiaa0277, Mrgef
Domain Architecture
Description	Rap guanine nucleotide exchange factor 5 (Guanine nucleotide exchange factor for Rap1) (M-Ras-regulated Rap GEF) (MR-GEF).

RPGF5_HUMAN
NC score	0.090718 (rank : 55)	θ value	θ > 10 (rank : 81)
Query Neighborhood Hits	52	Target Neighborhood Hits	42	Shared Neighborhood Hits	5
SwissProt Accessions	Q92565, Q8IXU5	Gene names	RAPGEF5, GFR, KIAA0277, MRGEF
Domain Architecture
Description	Rap guanine nucleotide exchange factor 5 (Guanine nucleotide exchange factor for Rap1) (Related to Epac) (Repac) (M-Ras-regulated Rap GEF) (MR-GEF).

RPGF2_HUMAN
NC score	0.063512 (rank : 56)	θ value	θ > 10 (rank : 80)
Query Neighborhood Hits	52	Target Neighborhood Hits	242	Shared Neighborhood Hits	11
SwissProt Accessions	Q9Y4G8	Gene names	RAPGEF2, KIAA0313, NRAPGEP, PDZGEF1
Domain Architecture	No domain graphic available
Description	Rap guanine nucleotide exchange factor 2 (Neural RAP guanine nucleotide exchange protein) (nRap GEP) (PDZ domain-containing guanine nucleotide exchange factor 1) (PDZ-GEF1) (RA-GEF).

PRKX_MOUSE
NC score	0.057705 (rank : 57)	θ value	θ > 10 (rank : 77)
Query Neighborhood Hits	52	Target Neighborhood Hits	846	Shared Neighborhood Hits	5
SwissProt Accessions	Q922R0, Q3UCD1, Q8BHD6, Q9QZ12	Gene names	Prkx, Pkare
Domain Architecture
Description	Serine/threonine-protein kinase PRKX (EC 2.7.11.1) (PKA-related protein kinase).

PRKX_HUMAN
NC score	0.057636 (rank : 58)	θ value	θ > 10 (rank : 76)
Query Neighborhood Hits	52	Target Neighborhood Hits	847	Shared Neighborhood Hits	5
SwissProt Accessions	P51817	Gene names	PRKX, PKX1
Domain Architecture
Description	Serine/threonine-protein kinase PRKX (EC 2.7.11.1) (Protein kinase PKX1).

ST38L_MOUSE
NC score	0.056920 (rank : 59)	θ value	θ > 10 (rank : 89)
Query Neighborhood Hits	52	Target Neighborhood Hits	821	Shared Neighborhood Hits	5
SwissProt Accessions	Q7TSE6, Q6P6K6, Q8BWK4	Gene names	Stk38l, Ndr2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 38-like (EC 2.7.11.1) (NDR2 protein kinase) (Nuclear Dbf2-related kinase 2).

KAPCA_MOUSE
NC score	0.056582 (rank : 60)	θ value	θ > 10 (rank : 54)
Query Neighborhood Hits	52	Target Neighborhood Hits	836	Shared Neighborhood Hits	5
SwissProt Accessions	P05132, Q9JID0	Gene names	Prkaca, Pkaca
Domain Architecture
Description	cAMP-dependent protein kinase, alpha-catalytic subunit (EC 2.7.11.11) (PKA C-alpha).

KAPCB_MOUSE
NC score	0.056451 (rank : 61)	θ value	θ > 10 (rank : 56)
Query Neighborhood Hits	52	Target Neighborhood Hits	836	Shared Neighborhood Hits	5
SwissProt Accessions	P68181, P05206, Q3TQH5, Q3UDD0, Q3UTH5	Gene names	Prkacb, Pkacb
Domain Architecture	No domain graphic available
Description	cAMP-dependent protein kinase, beta-catalytic subunit (EC 2.7.11.11) (PKA C-beta).

KAPCB_HUMAN
NC score	0.056272 (rank : 62)	θ value	θ > 10 (rank : 55)
Query Neighborhood Hits	52	Target Neighborhood Hits	837	Shared Neighborhood Hits	5
SwissProt Accessions	P22694, Q59GC0, Q5BNE9, Q5BNF0, Q5BNF1, Q5BNF2, Q5BNF3, Q5CZ92, Q5T1K3, Q7Z3M1, Q8IYR5, Q8IZQ0	Gene names	PRKACB
Domain Architecture
Description	cAMP-dependent protein kinase, beta-catalytic subunit (EC 2.7.11.11) (PKA C-beta).

KAPCA_HUMAN
NC score	0.056230 (rank : 63)	θ value	θ > 10 (rank : 53)
Query Neighborhood Hits	52	Target Neighborhood Hits	838	Shared Neighborhood Hits	5
SwissProt Accessions	P17612, Q9H2Y0, Q9NRB4, Q9NRH9	Gene names	PRKACA, PKACA
Domain Architecture
Description	cAMP-dependent protein kinase, alpha-catalytic subunit (EC 2.7.11.11) (PKA C-alpha).

LATS2_HUMAN
NC score	0.056182 (rank : 64)	θ value	θ > 10 (rank : 72)
Query Neighborhood Hits	52	Target Neighborhood Hits	884	Shared Neighborhood Hits	5
SwissProt Accessions	Q9NRM7, Q9P2X1	Gene names	LATS2, KPM
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase LATS2 (EC 2.7.11.1) (Large tumor suppressor homolog 2) (Serine/threonine-protein kinase kpm) (Kinase phosphorylated during mitosis protein) (Warts-like kinase).

ST38L_HUMAN
NC score	0.056154 (rank : 65)	θ value	θ > 10 (rank : 88)
Query Neighborhood Hits	52	Target Neighborhood Hits	824	Shared Neighborhood Hits	5
SwissProt Accessions	Q9Y2H1, Q8TBX7	Gene names	STK38L, KIAA0965, NDR2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 38-like (EC 2.7.11.1) (NDR2 protein kinase) (Nuclear Dbf2-related kinase 2).

STK38_HUMAN
NC score	0.056016 (rank : 66)	θ value	θ > 10 (rank : 90)
Query Neighborhood Hits	52	Target Neighborhood Hits	840	Shared Neighborhood Hits	5
SwissProt Accessions	Q15208	Gene names	STK38, NDR1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 38 (EC 2.7.11.1) (NDR1 protein kinase) (Nuclear Dbf2-related kinase 1).

STK38_MOUSE
NC score	0.055896 (rank : 67)	θ value	θ > 10 (rank : 91)
Query Neighborhood Hits	52	Target Neighborhood Hits	838	Shared Neighborhood Hits	5
SwissProt Accessions	Q91VJ4	Gene names	Stk38, Ndr1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 38 (EC 2.7.11.1) (NDR1 protein kinase) (Nuclear Dbf2-related kinase 1).

LATS2_MOUSE
NC score	0.055195 (rank : 68)	θ value	θ > 10 (rank : 73)
Query Neighborhood Hits	52	Target Neighborhood Hits	879	Shared Neighborhood Hits	5
SwissProt Accessions	Q7TSJ6, Q8CDJ4, Q9JMI3	Gene names	Lats2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase LATS2 (EC 2.7.11.1) (Large tumor suppressor homolog 2) (Serine/threonine-protein kinase kpm) (Kinase phosphorylated during mitosis protein).

LATS1_HUMAN
NC score	0.055178 (rank : 69)	θ value	θ > 10 (rank : 70)
Query Neighborhood Hits	52	Target Neighborhood Hits	1057	Shared Neighborhood Hits	5
SwissProt Accessions	O95835, Q6PKD0	Gene names	LATS1, WARTS
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase LATS1 (EC 2.7.11.1) (Large tumor suppressor homolog 1) (WARTS protein kinase) (h-warts).

LATS1_MOUSE
NC score	0.055111 (rank : 70)	θ value	θ > 10 (rank : 71)
Query Neighborhood Hits	52	Target Neighborhood Hits	1027	Shared Neighborhood Hits	5
SwissProt Accessions	Q8BYR2, Q9Z0W4	Gene names	Lats1, Warts
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase LATS1 (EC 2.7.11.1) (Large tumor suppressor homolog 1) (WARTS protein kinase).

RPKL1_HUMAN
NC score	0.055066 (rank : 71)	θ value	θ > 10 (rank : 83)
Query Neighborhood Hits	52	Target Neighborhood Hits	708	Shared Neighborhood Hits	7
SwissProt Accessions	Q9Y6S9, Q69YT9, Q6ZMQ6, Q96NR9, Q9BSU9	Gene names	RPS6KL1
Domain Architecture	No domain graphic available
Description	Ribosomal protein S6 kinase-like 1 (EC 2.7.11.1).

KAPCG_HUMAN
NC score	0.055018 (rank : 72)	θ value	θ > 10 (rank : 57)
Query Neighborhood Hits	52	Target Neighborhood Hits	845	Shared Neighborhood Hits	5
SwissProt Accessions	P22612, O60850, Q86YI1	Gene names	PRKACG
Domain Architecture
Description	cAMP-dependent protein kinase, gamma-catalytic subunit (EC 2.7.11.11) (PKA C-gamma).

SCYL2_MOUSE
NC score	0.054218 (rank : 73)	θ value	θ > 10 (rank : 85)
Query Neighborhood Hits	52	Target Neighborhood Hits	603	Shared Neighborhood Hits	6
SwissProt Accessions	Q8CFE4, Q3UT57, Q3UWU9, Q8K0M4	Gene names	Scyl2, Cvak104, D10Ertd802e
Domain Architecture	No domain graphic available
Description	SCY1-like protein 2 (Coated vesicle-associated kinase of 104 kDa).

RPGF1_HUMAN
NC score	0.053781 (rank : 74)	θ value	θ > 10 (rank : 79)
Query Neighborhood Hits	52	Target Neighborhood Hits	262	Shared Neighborhood Hits	6
SwissProt Accessions	Q13905	Gene names	RAPGEF1, GRF2
Domain Architecture
Description	Rap guanine nucleotide exchange factor 1 (Guanine nucleotide-releasing factor 2) (C3G protein) (CRK SH3-binding GNRP).

SCYL2_HUMAN
NC score	0.053748 (rank : 75)	θ value	θ > 10 (rank : 84)
Query Neighborhood Hits	52	Target Neighborhood Hits	632	Shared Neighborhood Hits	5
SwissProt Accessions	Q6P3W7, Q96EF4, Q96ST4, Q9H7V5, Q9NVH3, Q9P2I7	Gene names	SCYL2, CVAK104, KIAA1360
Domain Architecture	No domain graphic available
Description	SCY1-like protein 2 (Coated vesicle-associated kinase of 104 kDa).

KS6C1_HUMAN
NC score	0.053551 (rank : 76)	θ value	θ > 10 (rank : 68)
Query Neighborhood Hits	52	Target Neighborhood Hits	682	Shared Neighborhood Hits	5
SwissProt Accessions	Q96S38, Q8TDD3, Q9NSF4, Q9UL66	Gene names	RPS6KC1, RPK118
Domain Architecture	No domain graphic available
Description	Ribosomal protein S6 kinase delta-1 (EC 2.7.11.1) (52 kDa ribosomal protein S6 kinase) (Ribosomal S6 kinase-like protein with two PSK domains 118 kDa protein) (SPHK1-binding protein).

PRKY_HUMAN
NC score	0.052923 (rank : 77)	θ value	θ > 10 (rank : 78)
Query Neighborhood Hits	52	Target Neighborhood Hits	844	Shared Neighborhood Hits	5
SwissProt Accessions	O43930, O15348, O15349	Gene names	PRKY
Domain Architecture
Description	Serine/threonine-protein kinase PRKY (EC 2.7.11.1).

KS6C1_MOUSE
NC score	0.052292 (rank : 78)	θ value	θ > 10 (rank : 69)
Query Neighborhood Hits	52	Target Neighborhood Hits	700	Shared Neighborhood Hits	5
SwissProt Accessions	Q8BLK9, Q3UDY3, Q6PDY4, Q8BMQ5, Q8BX49	Gene names	Rps6kc1
Domain Architecture	No domain graphic available
Description	Ribosomal protein S6 kinase delta-1 (EC 2.7.11.1) (52 kDa ribosomal protein S6 kinase).

KS6B2_MOUSE
NC score	0.051749 (rank : 79)	θ value	θ > 10 (rank : 67)
Query Neighborhood Hits	52	Target Neighborhood Hits	871	Shared Neighborhood Hits	5
SwissProt Accessions	Q9Z1M4	Gene names	Rps6kb2
Domain Architecture
Description	Ribosomal protein S6 kinase beta-2 (EC 2.7.11.1) (S6K-beta 2) (70 kDa ribosomal protein S6 kinase 2) (p70-S6KB) (p70 ribosomal S6 kinase beta) (p70 S6Kbeta) (S6K2).

KS6B2_HUMAN
NC score	0.051212 (rank : 80)	θ value	θ > 10 (rank : 66)
Query Neighborhood Hits	52	Target Neighborhood Hits	858	Shared Neighborhood Hits	5
SwissProt Accessions	Q9UBS0, O94809, Q9UEC1	Gene names	RPS6KB2, STK14B
Domain Architecture
Description	Ribosomal protein S6 kinase beta-2 (EC 2.7.11.1) (S6K2) (70 kDa ribosomal protein S6 kinase 2) (p70-S6KB) (p70 ribosomal S6 kinase beta) (p70 S6Kbeta) (p70 S6 kinase beta) (S6K-beta) (p70-beta) (S6 kinase-related kinase) (SRK) (Serine/threonine-protein kinase 14 beta).

PKN3_HUMAN
NC score	0.050370 (rank : 81)	θ value	θ > 10 (rank : 74)
Query Neighborhood Hits	52	Target Neighborhood Hits	893	Shared Neighborhood Hits	5
SwissProt Accessions	Q6P5Z2, Q9UM03	Gene names	PKN3, PKNBETA
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase N3 (EC 2.7.11.13) (Protein kinase PKN- beta) (Protein-kinase C-related kinase 3).

KS6B1_HUMAN
NC score	0.050221 (rank : 82)	θ value	θ > 10 (rank : 64)
Query Neighborhood Hits	52	Target Neighborhood Hits	850	Shared Neighborhood Hits	6
SwissProt Accessions	P23443	Gene names	RPS6KB1
Domain Architecture
Description	Ribosomal protein S6 kinase beta-1 (EC 2.7.11.1) (Ribosomal protein S6 kinase I) (S6K) (S6K1) (70 kDa ribosomal protein S6 kinase 1) (p70 S6 kinase alpha) (p70(S6K)-alpha) (p70-S6K) (P70S6K) (p70-alpha).

KS6B1_MOUSE
NC score	0.050220 (rank : 83)	θ value	θ > 10 (rank : 65)
Query Neighborhood Hits	52	Target Neighborhood Hits	849	Shared Neighborhood Hits	6
SwissProt Accessions	Q8BSK8, Q8CHX0	Gene names	Rps6kb1
Domain Architecture	No domain graphic available
Description	Ribosomal protein S6 kinase beta-1 (EC 2.7.11.1) (Ribosomal protein S6 kinase I) (S6K) (S6K1) (70 kDa ribosomal protein S6 kinase 1) (p70 S6 kinase alpha) (p70(S6K)-alpha) (p70-S6K) (P70S6K).

PKN3_MOUSE
NC score	0.050084 (rank : 84)	θ value	θ > 10 (rank : 75)
Query Neighborhood Hits	52	Target Neighborhood Hits	1009	Shared Neighborhood Hits	9
SwissProt Accessions	Q8K045	Gene names	Pkn3, Pknbeta
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase N3 (EC 2.7.11.13) (Protein kinase PKN- beta) (Protein-kinase C-related kinase 3).

HRB2_HUMAN
NC score	0.021565 (rank : 85)	θ value	3.0926 (rank : 46)
Query Neighborhood Hits	52	Target Neighborhood Hits	41	Shared Neighborhood Hits	3
SwissProt Accessions	Q13601, Q8NEA8, Q8TC37, Q96AT5	Gene names	HRB2
Domain Architecture	No domain graphic available
Description	HIV-1 Rev-binding protein 2 (Rev-interacting protein 1) (Rip-1).

AKAP8_HUMAN
NC score	0.017233 (rank : 86)	θ value	2.36792 (rank : 44)
Query Neighborhood Hits	52	Target Neighborhood Hits	166	Shared Neighborhood Hits	4
SwissProt Accessions	O43823	Gene names	AKAP8, AKAP95
Domain Architecture
Description	A-kinase anchor protein 8 (A-kinase anchor protein 95 kDa) (AKAP 95).

CD3E_MOUSE
NC score	0.010479 (rank : 87)	θ value	8.99809 (rank : 50)
Query Neighborhood Hits	52	Target Neighborhood Hits	34	Shared Neighborhood Hits	2
SwissProt Accessions	P22646	Gene names	Cd3e
Domain Architecture
Description	T-cell surface glycoprotein CD3 epsilon chain precursor (T-cell surface antigen T3/Leu-4 epsilon chain).

CB017_MOUSE
NC score	0.008358 (rank : 88)	θ value	8.99809 (rank : 49)
Query Neighborhood Hits	52	Target Neighborhood Hits	63	Shared Neighborhood Hits	2
SwissProt Accessions	Q6NS82, Q3TA48, Q8BSD3, Q8CHY1, Q8R0Q3	Gene names
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C2orf17 homolog.

MYST3_HUMAN
NC score	0.003687 (rank : 89)	θ value	6.88961 (rank : 47)
Query Neighborhood Hits	52	Target Neighborhood Hits	772	Shared Neighborhood Hits	4
SwissProt Accessions	Q92794	Gene names	MYST3, MOZ, RUNXBP2, ZNF220
Domain Architecture
Description	Histone acetyltransferase MYST3 (EC 2.3.1.48) (EC 2.3.1.-) (MYST protein 3) (MOZ, YBF2/SAS3, SAS2 and TIP60 protein 3) (Runt-related transcription factor-binding protein 2) (Monocytic leukemia zinc finger protein) (Zinc finger protein 220).

RIMB1_HUMAN
NC score	0.001640 (rank : 90)	θ value	6.88961 (rank : 48)
Query Neighborhood Hits	52	Target Neighborhood Hits	1479	Shared Neighborhood Hits	6
SwissProt Accessions	O95153, O75111, Q8N5W3	Gene names	BZRAP1, KIAA0612, RBP1
Domain Architecture
Description	Peripheral-type benzodiazepine receptor-associated protein 1 (PRAX-1) (Peripheral benzodiazepine receptor-interacting protein) (PBR-IP) (RIM-binding protein 1) (RIM-BP1).

CJ118_MOUSE
NC score	-0.000294 (rank : 91)	θ value	8.99809 (rank : 51)
Query Neighborhood Hits	52	Target Neighborhood Hits	1132	Shared Neighborhood Hits	5
SwissProt Accessions	Q8C9S4, Q6P3D6, Q8CJC0	Gene names	Otg1
Domain Architecture	No domain graphic available
Description	Protein C10orf118 homolog (Oocyte-testis gene 1 protein).