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Network neighborhood for query Sequence : CNGB3_MOUSE

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CNGB3_MOUSE
SwissProt Accessions	Q9JJZ9	Gene names	Cngb3, Cng6
Domain Architecture
Description	Cyclic nucleotide-gated cation channel beta 3 (CNG channel beta 3) (Cyclic nucleotide-gated channel beta 3) (Cone photoreceptor cGMP- gated channel subunit beta) (Cyclic nucleotide-gated cation channel modulatory subunit) (Cyclic nucleotide-gated channel subunit CNG6).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

CNGB3_HUMAN
θ value	0 (rank : 1)	NC score	0.981723 (rank : 2)
Query Neighborhood Hits	74	Target Neighborhood Hits	206	Shared Neighborhood Hits	50
SwissProt Accessions	Q9NQW8, Q9NRE9	Gene names	CNGB3
Domain Architecture
Description	Cyclic nucleotide-gated cation channel beta 3 (CNG channel beta 3) (Cyclic nucleotide-gated channel beta 3) (Cone photoreceptor cGMP- gated channel subunit beta) (Cyclic nucleotide-gated cation channel modulatory subunit).

CNGB3_MOUSE
θ value	0 (rank : 2)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	74	Target Neighborhood Hits	74	Shared Neighborhood Hits	74
SwissProt Accessions	Q9JJZ9	Gene names	Cngb3, Cng6
Domain Architecture
Description	Cyclic nucleotide-gated cation channel beta 3 (CNG channel beta 3) (Cyclic nucleotide-gated channel beta 3) (Cone photoreceptor cGMP- gated channel subunit beta) (Cyclic nucleotide-gated cation channel modulatory subunit) (Cyclic nucleotide-gated channel subunit CNG6).

CNGB1_HUMAN
θ value	2.7506e-174 (rank : 3)	NC score	0.967749 (rank : 3)
Query Neighborhood Hits	74	Target Neighborhood Hits	222	Shared Neighborhood Hits	49
SwissProt Accessions	Q14028, Q14029	Gene names	CNGB1, CNCG4
Domain Architecture
Description	Cyclic nucleotide-gated cation channel 4 (CNG channel 4) (CNG-4) (CNG4) (Cyclic nucleotide-gated cation channel modulatory subunit).

CNGA1_MOUSE
θ value	2.82823e-78 (rank : 4)	NC score	0.938060 (rank : 8)
Query Neighborhood Hits	74	Target Neighborhood Hits	198	Shared Neighborhood Hits	48
SwissProt Accessions	P29974, Q60776	Gene names	Cnga1, Cncg, Cncg1
Domain Architecture
Description	cGMP-gated cation channel alpha 1 (CNG channel alpha 1) (CNG-1) (CNG1) (Cyclic nucleotide-gated channel alpha 1) (Cyclic nucleotide-gated channel, photoreceptor) (Cyclic nucleotide-gated cation channel 1) (Rod photoreceptor cGMP-gated channel subunit alpha).

CNGA1_HUMAN
θ value	8.22888e-78 (rank : 5)	NC score	0.941495 (rank : 6)
Query Neighborhood Hits	74	Target Neighborhood Hits	149	Shared Neighborhood Hits	46
SwissProt Accessions	P29973, Q16279, Q16485	Gene names	CNGA1, CNCG, CNCG1
Domain Architecture
Description	cGMP-gated cation channel alpha 1 (CNG channel alpha 1) (CNG-1) (CNG1) (Cyclic nucleotide-gated channel alpha 1) (Cyclic nucleotide-gated channel, photoreceptor) (Cyclic nucleotide-gated cation channel 1) (Rod photoreceptor cGMP-gated channel subunit alpha).

CNGA2_MOUSE
θ value	2.39424e-77 (rank : 6)	NC score	0.944876 (rank : 5)
Query Neighborhood Hits	74	Target Neighborhood Hits	86	Shared Neighborhood Hits	44
SwissProt Accessions	Q62398	Gene names	Cnga2, Cncg2, Cncg4
Domain Architecture
Description	Cyclic nucleotide-gated olfactory channel (Cyclic nucleotide-gated cation channel 2) (CNG channel 2) (CNG-2) (CNG2).

CNGA3_MOUSE
θ value	6.10265e-73 (rank : 7)	NC score	0.945191 (rank : 4)
Query Neighborhood Hits	74	Target Neighborhood Hits	84	Shared Neighborhood Hits	43
SwissProt Accessions	Q9JJZ8, Q9WV01	Gene names	Cnga3, Cng3
Domain Architecture
Description	Cyclic nucleotide-gated cation channel alpha 3 (CNG channel alpha 3) (CNG-3) (CNG3) (Cyclic nucleotide-gated channel alpha 3) (Cone photoreceptor cGMP-gated channel subunit alpha).

CNGA3_HUMAN
θ value	1.15091e-71 (rank : 8)	NC score	0.941061 (rank : 7)
Query Neighborhood Hits	74	Target Neighborhood Hits	125	Shared Neighborhood Hits	43
SwissProt Accessions	Q16281, Q9UP64	Gene names	CNGA3, CNCG3
Domain Architecture
Description	Cyclic nucleotide-gated cation channel alpha 3 (CNG channel alpha 3) (CNG-3) (CNG3) (Cyclic nucleotide-gated channel alpha 3) (Cone photoreceptor cGMP-gated channel subunit alpha).

HCN4_MOUSE
θ value	1.79631e-32 (rank : 9)	NC score	0.818549 (rank : 15)
Query Neighborhood Hits	74	Target Neighborhood Hits	284	Shared Neighborhood Hits	46
SwissProt Accessions	O70507	Gene names	Hcn4, Bcng3
Domain Architecture
Description	Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 (Brain cyclic nucleotide-gated channel 3) (BCNG-3).

HCN4_HUMAN
θ value	3.06405e-32 (rank : 10)	NC score	0.819443 (rank : 14)
Query Neighborhood Hits	74	Target Neighborhood Hits	303	Shared Neighborhood Hits	46
SwissProt Accessions	Q9Y3Q4, Q9UMQ7	Gene names	HCN4
Domain Architecture
Description	Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4.

HCN1_HUMAN
θ value	1.16434e-31 (rank : 11)	NC score	0.836323 (rank : 9)
Query Neighborhood Hits	74	Target Neighborhood Hits	120	Shared Neighborhood Hits	44
SwissProt Accessions	O60741	Gene names	HCN1, BCNG1
Domain Architecture
Description	Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1 (Brain cyclic nucleotide-gated channel 1) (BCNG-1).

HCN1_MOUSE
θ value	1.16434e-31 (rank : 12)	NC score	0.832592 (rank : 11)
Query Neighborhood Hits	74	Target Neighborhood Hits	172	Shared Neighborhood Hits	44
SwissProt Accessions	O88704, O54899, Q9D613	Gene names	Hcn1, Bcng1, Hac2
Domain Architecture
Description	Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1 (Brain cyclic nucleotide-gated channel 1) (BCNG-1) (Hyperpolarization-activated cation channel 2) (HAC-2).

HCN2_HUMAN
θ value	3.17079e-29 (rank : 13)	NC score	0.811784 (rank : 16)
Query Neighborhood Hits	74	Target Neighborhood Hits	369	Shared Neighborhood Hits	46
SwissProt Accessions	Q9UL51, O60742, O60743, O75267, Q9UBS2	Gene names	HCN2, BCNG2
Domain Architecture
Description	Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 (Brain cyclic nucleotide-gated channel 2) (BCNG-2).

HCN2_MOUSE
θ value	5.40856e-29 (rank : 14)	NC score	0.821401 (rank : 13)
Query Neighborhood Hits	74	Target Neighborhood Hits	278	Shared Neighborhood Hits	46
SwissProt Accessions	O88703, O70506	Gene names	Hcn2, Bcng2, Hac1
Domain Architecture
Description	Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 (Brain cyclic nucleotide-gated channel 2) (BCNG-2) (Hyperpolarization-activated cation channel 1) (HAC-1).

HCN3_MOUSE
θ value	5.40856e-29 (rank : 15)	NC score	0.833331 (rank : 10)
Query Neighborhood Hits	74	Target Neighborhood Hits	112	Shared Neighborhood Hits	43
SwissProt Accessions	O88705	Gene names	Hcn3, Hac3
Domain Architecture
Description	Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 3 (Hyperpolarization-activated cation channel 3) (HAC-3).

HCN3_HUMAN
θ value	2.68423e-28 (rank : 16)	NC score	0.832403 (rank : 12)
Query Neighborhood Hits	74	Target Neighborhood Hits	99	Shared Neighborhood Hits	44
SwissProt Accessions	Q9P1Z3, Q4VX12, Q8N6W6, Q9BWQ2	Gene names	HCN3, KIAA1535
Domain Architecture
Description	Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 3.

KCNH2_MOUSE
θ value	9.87957e-23 (rank : 17)	NC score	0.754511 (rank : 17)
Query Neighborhood Hits	74	Target Neighborhood Hits	165	Shared Neighborhood Hits	39
SwissProt Accessions	O35219, O35220, O35221, O35989	Gene names	Kcnh2, Erg, Merg1
Domain Architecture
Description	Potassium voltage-gated channel subfamily H member 2 (Voltage-gated potassium channel subunit Kv11.1) (Ether-a-go-go-related gene potassium channel 1) (ERG1) (MERG) (Merg1) (Ether-a-go-go-related protein 1) (Eag-related protein 1).

KCNH2_HUMAN
θ value	2.87452e-22 (rank : 18)	NC score	0.754483 (rank : 18)
Query Neighborhood Hits	74	Target Neighborhood Hits	158	Shared Neighborhood Hits	40
SwissProt Accessions	Q12809, O75418, O75680, Q9BT72, Q9BUT7, Q9H3P0	Gene names	KCNH2, ERG, ERG1, HERG, HERG1
Domain Architecture
Description	Potassium voltage-gated channel subfamily H member 2 (Voltage-gated potassium channel subunit Kv11.1) (Ether-a-go-go-related gene potassium channel 1) (H-ERG) (Erg1) (Ether-a-go-go-related protein 1) (Eag-related protein 1) (eag homolog).

KCNH5_HUMAN
θ value	3.51386e-20 (rank : 19)	NC score	0.745273 (rank : 23)
Query Neighborhood Hits	74	Target Neighborhood Hits	99	Shared Neighborhood Hits	33
SwissProt Accessions	Q8NCM2	Gene names	KCNH5, EAG2
Domain Architecture
Description	Potassium voltage-gated channel subfamily H member 5 (Voltage-gated potassium channel subunit Kv10.2) (Ether-a-go-go potassium channel 2) (hEAG2).

KCNH5_MOUSE
θ value	3.51386e-20 (rank : 20)	NC score	0.745779 (rank : 22)
Query Neighborhood Hits	74	Target Neighborhood Hits	102	Shared Neighborhood Hits	34
SwissProt Accessions	Q920E3, Q8C035	Gene names	Kcnh5, Eag2
Domain Architecture	No domain graphic available
Description	Potassium voltage-gated channel subfamily H member 5 (Voltage-gated potassium channel subunit Kv10.2) (Ether-a-go-go potassium channel 2) (Eag2).

KCNH1_HUMAN
θ value	1.92812e-18 (rank : 21)	NC score	0.739798 (rank : 27)
Query Neighborhood Hits	74	Target Neighborhood Hits	98	Shared Neighborhood Hits	38
SwissProt Accessions	O95259, O76035	Gene names	KCNH1, EAG, EAG1
Domain Architecture
Description	Potassium voltage-gated channel subfamily H member 1 (Voltage-gated potassium channel subunit Kv10.1) (Ether-a-go-go potassium channel 1) (hEAG1) (h-eag).

KCNH1_MOUSE
θ value	1.92812e-18 (rank : 22)	NC score	0.739996 (rank : 26)
Query Neighborhood Hits	74	Target Neighborhood Hits	94	Shared Neighborhood Hits	38
SwissProt Accessions	Q60603	Gene names	Kcnh1, Eag
Domain Architecture
Description	Potassium voltage-gated channel subfamily H member 1 (Voltage-gated potassium channel subunit Kv10.1) (Ether-a-go-go potassium channel 1) (EAG1) (m-eag).

KCNH7_MOUSE
θ value	2.5182e-18 (rank : 23)	NC score	0.751449 (rank : 19)
Query Neighborhood Hits	74	Target Neighborhood Hits	98	Shared Neighborhood Hits	39
SwissProt Accessions	Q9ER47	Gene names	Kcnh7, Erg3
Domain Architecture
Description	Potassium voltage-gated channel subfamily H member 7 (Voltage-gated potassium channel subunit Kv11.3) (Ether-a-go-go-related gene potassium channel 3) (Ether-a-go-go-related protein 3) (Eag-related protein 3).

KCNH7_HUMAN
θ value	4.29542e-18 (rank : 24)	NC score	0.747367 (rank : 21)
Query Neighborhood Hits	74	Target Neighborhood Hits	107	Shared Neighborhood Hits	40
SwissProt Accessions	Q9NS40	Gene names	KCNH7, ERG3
Domain Architecture
Description	Potassium voltage-gated channel subfamily H member 7 (Voltage-gated potassium channel subunit Kv11.3) (Ether-a-go-go-related gene potassium channel 3) (HERG-3) (Ether-a-go-go-related protein 3) (Eag- related protein 3).

KCNH6_HUMAN
θ value	7.32683e-18 (rank : 25)	NC score	0.749129 (rank : 20)
Query Neighborhood Hits	74	Target Neighborhood Hits	222	Shared Neighborhood Hits	39
SwissProt Accessions	Q9H252, Q9BRD7	Gene names	KCNH6, ERG2, HERG2
Domain Architecture
Description	Potassium voltage-gated channel subfamily H member 6 (Voltage-gated potassium channel subunit Kv11.2) (Ether-a-go-go-related gene potassium channel 2) (Ether-a-go-go-related protein 2) (Eag-related protein 2).

KCNH8_HUMAN
θ value	9.56915e-18 (rank : 26)	NC score	0.741179 (rank : 25)
Query Neighborhood Hits	74	Target Neighborhood Hits	104	Shared Neighborhood Hits	34
SwissProt Accessions	Q96L42	Gene names	KCNH8
Domain Architecture
Description	Potassium voltage-gated channel subfamily H member 8 (Voltage-gated potassium channel subunit Kv12.1) (Ether-a-go-go-like potassium channel 3) (ELK channel 3) (ELK3) (ELK1) (hElk1).

KCNH4_HUMAN
θ value	8.10077e-17 (rank : 27)	NC score	0.743110 (rank : 24)
Query Neighborhood Hits	74	Target Neighborhood Hits	177	Shared Neighborhood Hits	33
SwissProt Accessions	Q9UQ05	Gene names	KCNH4
Domain Architecture
Description	Potassium voltage-gated channel subfamily H member 4 (Voltage-gated potassium channel subunit Kv12.3) (Ether-a-go-go-like potassium channel 1) (ELK channel 1) (ELK1) (Brain-specific eag-like channel 2) (BEC2).

KCNH3_HUMAN
θ value	4.91457e-14 (rank : 28)	NC score	0.727910 (rank : 28)
Query Neighborhood Hits	74	Target Neighborhood Hits	148	Shared Neighborhood Hits	34
SwissProt Accessions	Q9ULD8, Q9UQ06	Gene names	KCNH3, KIAA1282
Domain Architecture
Description	Potassium voltage-gated channel subfamily H member 3 (Voltage-gated potassium channel subunit Kv12.2) (Ether-a-go-go-like potassium channel 2) (ELK channel 2) (ELK2) (Brain-specific eag-like channel 1) (BEC1).

KCNH3_MOUSE
θ value	5.43371e-13 (rank : 29)	NC score	0.726821 (rank : 29)
Query Neighborhood Hits	74	Target Neighborhood Hits	133	Shared Neighborhood Hits	33
SwissProt Accessions	Q9WVJ0	Gene names	Kcnh3, Elk2
Domain Architecture
Description	Potassium voltage-gated channel subfamily H member 3 (Voltage-gated potassium channel subunit Kv12.2) (Ether-a-go-go-like potassium channel 2) (ELK channel 2) (mElk2).

KGP2_HUMAN
θ value	0.000121331 (rank : 30)	NC score	0.080352 (rank : 45)
Query Neighborhood Hits	74	Target Neighborhood Hits	1023	Shared Neighborhood Hits	41
SwissProt Accessions	Q13237, O00125, O60916	Gene names	PRKG2, PRKGR2
Domain Architecture
Description	cGMP-dependent protein kinase 2 (EC 2.7.11.12) (CGK 2) (cGKII) (Type II cGMP-dependent protein kinase).

KGP2_MOUSE
θ value	0.000121331 (rank : 31)	NC score	0.080025 (rank : 46)
Query Neighborhood Hits	74	Target Neighborhood Hits	1029	Shared Neighborhood Hits	40
SwissProt Accessions	Q61410	Gene names	Prkg2, Prkgr2
Domain Architecture
Description	cGMP-dependent protein kinase 2 (EC 2.7.11.12) (CGK 2) (cGKII) (Type II cGMP-dependent protein kinase).

KAP0_HUMAN
θ value	0.00134147 (rank : 32)	NC score	0.294649 (rank : 30)
Query Neighborhood Hits	74	Target Neighborhood Hits	52	Shared Neighborhood Hits	41
SwissProt Accessions	P10644, Q567S7	Gene names	PRKAR1A, PKR1, PRKAR1
Domain Architecture
Description	cAMP-dependent protein kinase type I-alpha regulatory subunit (Tissue- specific extinguisher 1) (TSE1).

KGP1B_MOUSE
θ value	0.00298849 (rank : 33)	NC score	0.079794 (rank : 47)
Query Neighborhood Hits	74	Target Neighborhood Hits	922	Shared Neighborhood Hits	49
SwissProt Accessions	Q9Z0Z0	Gene names	Prkg1, Prkg1b, Prkgr1b
Domain Architecture
Description	cGMP-dependent protein kinase 1, beta isozyme (EC 2.7.11.12) (cGK 1 beta) (cGKI-beta).

KAP0_MOUSE
θ value	0.00390308 (rank : 34)	NC score	0.276288 (rank : 32)
Query Neighborhood Hits	74	Target Neighborhood Hits	48	Shared Neighborhood Hits	41
SwissProt Accessions	Q9DBC7, Q3UKU7, Q9JHR5, Q9JHR6	Gene names	Prkar1a
Domain Architecture	No domain graphic available
Description	cAMP-dependent protein kinase type I-alpha regulatory subunit.

KAP2_HUMAN
θ value	0.00665767 (rank : 35)	NC score	0.235175 (rank : 35)
Query Neighborhood Hits	74	Target Neighborhood Hits	48	Shared Neighborhood Hits	31
SwissProt Accessions	P13861, Q16823	Gene names	PRKAR2A, PKR2, PRKAR2
Domain Architecture
Description	cAMP-dependent protein kinase type II-alpha regulatory subunit.

KAP2_MOUSE
θ value	0.00665767 (rank : 36)	NC score	0.238252 (rank : 34)
Query Neighborhood Hits	74	Target Neighborhood Hits	44	Shared Neighborhood Hits	31
SwissProt Accessions	P12367	Gene names	Prkar2a
Domain Architecture
Description	cAMP-dependent protein kinase type II-alpha regulatory subunit.

KGP1A_HUMAN
θ value	0.00665767 (rank : 37)	NC score	0.078889 (rank : 49)
Query Neighborhood Hits	74	Target Neighborhood Hits	901	Shared Neighborhood Hits	49
SwissProt Accessions	Q13976	Gene names	PRKG1, PRKGR1A
Domain Architecture
Description	cGMP-dependent protein kinase 1, alpha isozyme (EC 2.7.11.12) (CGK 1 alpha) (cGKI-alpha).

KGP1B_HUMAN
θ value	0.00665767 (rank : 38)	NC score	0.079247 (rank : 48)
Query Neighborhood Hits	74	Target Neighborhood Hits	921	Shared Neighborhood Hits	49
SwissProt Accessions	P14619	Gene names	PRKG1, PRKG1B, PRKGR1B
Domain Architecture
Description	cGMP-dependent protein kinase 1, beta isozyme (EC 2.7.11.12) (cGK 1 beta) (cGKI-beta).

KAP1_MOUSE
θ value	0.00869519 (rank : 39)	NC score	0.272317 (rank : 33)
Query Neighborhood Hits	74	Target Neighborhood Hits	49	Shared Neighborhood Hits	39
SwissProt Accessions	P12849	Gene names	Prkar1b
Domain Architecture
Description	cAMP-dependent protein kinase type I-beta regulatory subunit.

KAP1_HUMAN
θ value	0.0113563 (rank : 40)	NC score	0.276654 (rank : 31)
Query Neighborhood Hits	74	Target Neighborhood Hits	58	Shared Neighborhood Hits	39
SwissProt Accessions	P31321	Gene names	PRKAR1B
Domain Architecture
Description	cAMP-dependent protein kinase type I-beta regulatory subunit.

RPGF3_MOUSE
θ value	0.0330416 (rank : 41)	NC score	0.096105 (rank : 42)
Query Neighborhood Hits	74	Target Neighborhood Hits	54	Shared Neighborhood Hits	24
SwissProt Accessions	Q8VCC8, Q8BZK9, Q8R1R1	Gene names	Rapgef3, Epac, Epac1
Domain Architecture
Description	Rap guanine nucleotide exchange factor 3 (cAMP-regulated guanine nucleotide exchange factor I) (cAMP-GEFI) (Exchange factor directly activated by cAMP 1) (Epac 1).

RPGF4_MOUSE
θ value	0.0961366 (rank : 42)	NC score	0.104582 (rank : 40)
Query Neighborhood Hits	74	Target Neighborhood Hits	80	Shared Neighborhood Hits	30
SwissProt Accessions	Q9EQZ6, Q8VIP9, Q9CW52, Q9Z1P0	Gene names	Rapgef4, Cgef2, Epac2
Domain Architecture
Description	Rap guanine nucleotide exchange factor 4 (cAMP-regulated guanine nucleotide exchange factor II) (cAMP-GEFII) (Exchange factor directly activated by cAMP 2) (Epac 2) (cAMP-dependent Rap1 guanine-nucleotide exchange factor).

TTF2_HUMAN
θ value	0.0961366 (rank : 43)	NC score	0.017910 (rank : 58)
Query Neighborhood Hits	74	Target Neighborhood Hits	98	Shared Neighborhood Hits	2
SwissProt Accessions	Q9UNY4, O75921, Q5T2K7, Q5VVU8, Q8N6I8	Gene names	TTF2
Domain Architecture	No domain graphic available
Description	Transcription termination factor 2 (EC 3.6.1.-) (RNA polymerase II termination factor) (Transcription release factor 2) (Factor 2) (F2) (HuF2) (Lodestar homolog).

BPAEA_HUMAN
θ value	0.163984 (rank : 44)	NC score	0.009800 (rank : 67)
Query Neighborhood Hits	74	Target Neighborhood Hits	1369	Shared Neighborhood Hits	13
SwissProt Accessions	O94833, Q5TBT0, Q8N1T8, Q8N8J3, Q8WXK9, Q96AK9, Q96DQ5, Q9H555	Gene names	DST, BPAG1, DMH, DT, KIAA0728
Domain Architecture
Description	Bullous pemphigoid antigen 1, isoforms 6/9/10 (Trabeculin-beta) (Bullous pemphigoid antigen) (BPA) (Hemidesmosomal plaque protein) (Dystonia musculorum protein) (Dystonin).

RPGF4_HUMAN
θ value	0.279714 (rank : 45)	NC score	0.100125 (rank : 41)
Query Neighborhood Hits	74	Target Neighborhood Hits	88	Shared Neighborhood Hits	30
SwissProt Accessions	Q8WZA2, O95636, Q8IXK6, Q8TAA4	Gene names	RAPGEF4, CGEF2, EPAC2
Domain Architecture
Description	Rap guanine nucleotide exchange factor 4 (cAMP-regulated guanine nucleotide exchange factor II) (cAMP-GEFII) (Exchange factor directly activated by cAMP 2) (Epac 2).

KAP3_HUMAN
θ value	0.365318 (rank : 46)	NC score	0.229313 (rank : 37)
Query Neighborhood Hits	74	Target Neighborhood Hits	40	Shared Neighborhood Hits	33
SwissProt Accessions	P31323	Gene names	PRKAR2B
Domain Architecture
Description	cAMP-dependent protein kinase type II-beta regulatory subunit.

KAP3_MOUSE
θ value	0.365318 (rank : 47)	NC score	0.234357 (rank : 36)
Query Neighborhood Hits	74	Target Neighborhood Hits	43	Shared Neighborhood Hits	33
SwissProt Accessions	P31324, Q3UTZ1, Q80ZM4, Q8BRZ7	Gene names	Prkar2b
Domain Architecture	No domain graphic available
Description	cAMP-dependent protein kinase type II-beta regulatory subunit.

CT152_MOUSE
θ value	0.62314 (rank : 48)	NC score	0.180402 (rank : 38)
Query Neighborhood Hits	74	Target Neighborhood Hits	38	Shared Neighborhood Hits	34
SwissProt Accessions	Q9D5U8, Q8R083	Gene names
Domain Architecture
Description	Uncharacterized protein C20orf152 homolog.

ATAD3_MOUSE
θ value	1.38821 (rank : 49)	NC score	0.012946 (rank : 64)
Query Neighborhood Hits	74	Target Neighborhood Hits	326	Shared Neighborhood Hits	5
SwissProt Accessions	Q925I1, Q3UE74, Q69ZM7, Q8C6C6	Gene names	Atad3, Atad3a, Kiaa1273
Domain Architecture	No domain graphic available
Description	ATPase family AAA domain-containing protein 3 (AAA-ATPase TOB3).

KCNF1_HUMAN
θ value	1.81305 (rank : 50)	NC score	0.008729 (rank : 72)
Query Neighborhood Hits	74	Target Neighborhood Hits	109	Shared Neighborhood Hits	8
SwissProt Accessions	Q9H3M0, O43527	Gene names	KCNF1
Domain Architecture
Description	Potassium voltage-gated channel subfamily F member 1 (Voltage-gated potassium channel subunit Kv5.1) (kH1).

DVL3_MOUSE
θ value	2.36792 (rank : 51)	NC score	0.009634 (rank : 68)
Query Neighborhood Hits	74	Target Neighborhood Hits	198	Shared Neighborhood Hits	5
SwissProt Accessions	Q61062	Gene names	Dvl3
Domain Architecture
Description	Segment polarity protein dishevelled homolog DVL-3 (Dishevelled-3) (DSH homolog 3).

ROCK2_MOUSE
θ value	2.36792 (rank : 52)	NC score	0.006947 (rank : 76)
Query Neighborhood Hits	74	Target Neighborhood Hits	2072	Shared Neighborhood Hits	18
SwissProt Accessions	P70336, Q8BR64, Q8CBR0	Gene names	Rock2
Domain Architecture
Description	Rho-associated protein kinase 2 (EC 2.7.11.1) (Rho-associated, coiled- coil-containing protein kinase 2) (p164 ROCK-2).

RSF1_HUMAN
θ value	3.0926 (rank : 53)	NC score	0.008910 (rank : 71)
Query Neighborhood Hits	74	Target Neighborhood Hits	539	Shared Neighborhood Hits	8
SwissProt Accessions	Q96T23, Q86X86, Q9H3L8, Q9NVZ8, Q9NYU0	Gene names	RSF1, HBXAP, XAP8
Domain Architecture	No domain graphic available
Description	Remodeling and spacing factor 1 (Rsf-1) (Hepatitis B virus X- associated protein) (HBV pX-associated protein 8) (p325 subunit of RSF chromatin remodelling complex).

AFF1_MOUSE
θ value	4.03905 (rank : 54)	NC score	0.014458 (rank : 62)
Query Neighborhood Hits	74	Target Neighborhood Hits	351	Shared Neighborhood Hits	7
SwissProt Accessions	O88573	Gene names	Aff1, Mllt2, Mllt2h
Domain Architecture
Description	AF4/FMR2 family member 1 (Protein AF-4) (Proto-oncogene AF4).

CCNB3_MOUSE
θ value	4.03905 (rank : 55)	NC score	0.008420 (rank : 73)
Query Neighborhood Hits	74	Target Neighborhood Hits	211	Shared Neighborhood Hits	7
SwissProt Accessions	Q810T2, Q810T3, Q8VDC8	Gene names	Ccnb3, Cycb3
Domain Architecture
Description	G2/mitotic-specific cyclin-B3.

MIPO1_HUMAN
θ value	4.03905 (rank : 56)	NC score	0.006908 (rank : 77)
Query Neighborhood Hits	74	Target Neighborhood Hits	486	Shared Neighborhood Hits	7
SwissProt Accessions	Q8TD10, Q7Z3J0, Q8IV14	Gene names	MIPOL1
Domain Architecture	No domain graphic available
Description	Mirror-image polydactyly gene 1 protein.

NHS_HUMAN
θ value	4.03905 (rank : 57)	NC score	0.014757 (rank : 60)
Query Neighborhood Hits	74	Target Neighborhood Hits	198	Shared Neighborhood Hits	3
SwissProt Accessions	Q6T4R5, Q5J7Q0, Q5J7Q1, Q68DR5	Gene names	NHS
Domain Architecture	No domain graphic available
Description	Nance-Horan syndrome protein (Congenital cataracts and dental anomalies protein).

PSMD2_MOUSE
θ value	4.03905 (rank : 58)	NC score	0.013513 (rank : 63)
Query Neighborhood Hits	74	Target Neighborhood Hits	147	Shared Neighborhood Hits	4
SwissProt Accessions	Q8VDM4	Gene names	Psmd2
Domain Architecture	No domain graphic available
Description	26S proteasome non-ATPase regulatory subunit 2 (26S proteasome regulatory subunit RPN1) (26S proteasome regulatory subunit S2) (26S proteasome subunit p97).

SETD2_HUMAN
θ value	4.03905 (rank : 59)	NC score	0.007987 (rank : 74)
Query Neighborhood Hits	74	Target Neighborhood Hits	412	Shared Neighborhood Hits	7
SwissProt Accessions	Q9BYW2, O75397, O75405, Q17RW8, Q5BKS9, Q5QGN2, Q69YI5, Q6IN64, Q6ZN53, Q6ZS25, Q8N3R0, Q8TCN0, Q9C0D1, Q9H696, Q9NZW9	Gene names	SETD2, HIF1, HYPB, KIAA1732, SET2
Domain Architecture	No domain graphic available
Description	Histone-lysine N-methyltransferase, H3 lysine-36-specific (EC 2.1.1.43) (SET domain-containing protein 2) (hSET2) (Huntingtin- interacting protein HYPB) (Huntingtin-interacting protein 1) (HIF-1) (p231HBP).

UBP37_HUMAN
θ value	4.03905 (rank : 60)	NC score	0.006295 (rank : 78)
Query Neighborhood Hits	74	Target Neighborhood Hits	208	Shared Neighborhood Hits	3
SwissProt Accessions	Q86T82, Q9HCH8	Gene names	USP37, KIAA1594
Domain Architecture
Description	Ubiquitin carboxyl-terminal hydrolase 37 (EC 3.1.2.15) (Ubiquitin thioesterase 37) (Ubiquitin-specific-processing protease 37) (Deubiquitinating enzyme 37).

MAP1B_MOUSE
θ value	5.27518 (rank : 61)	NC score	0.016089 (rank : 59)
Query Neighborhood Hits	74	Target Neighborhood Hits	977	Shared Neighborhood Hits	17
SwissProt Accessions	P14873	Gene names	Map1b, Mtap1b, Mtap5
Domain Architecture	No domain graphic available
Description	Microtubule-associated protein 1B (MAP 1B) (MAP1.2) (MAP1(X)) [Contains: MAP1 light chain LC1].

NFH_MOUSE
θ value	5.27518 (rank : 62)	NC score	0.022437 (rank : 57)
Query Neighborhood Hits	74	Target Neighborhood Hits	2247	Shared Neighborhood Hits	31
SwissProt Accessions	P19246, Q5SVF6, Q61959	Gene names	Nefh, Nfh
Domain Architecture
Description	Neurofilament triplet H protein (200 kDa neurofilament protein) (Neurofilament heavy polypeptide) (NF-H).

NOP56_MOUSE
θ value	5.27518 (rank : 63)	NC score	0.009435 (rank : 69)
Query Neighborhood Hits	74	Target Neighborhood Hits	129	Shared Neighborhood Hits	5
SwissProt Accessions	Q9D6Z1, Q3UD45, Q8BVL1, Q8VDT2, Q99LT8, Q9CT15	Gene names	Nol5a, Nop56
Domain Architecture
Description	Nucleolar protein Nop56 (Nucleolar protein 5A).

PKHA5_HUMAN
θ value	5.27518 (rank : 64)	NC score	0.010427 (rank : 65)
Query Neighborhood Hits	74	Target Neighborhood Hits	455	Shared Neighborhood Hits	11
SwissProt Accessions	Q9HAU0, Q8N3K6, Q96DY9, Q9BVR4, Q9C0H7, Q9H924, Q9NVK8	Gene names	PLEKHA5, KIAA1686, PEPP2
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 5 (Phosphoinositol 3-phosphate-binding protein 2) (PEPP-2).

PRG4_HUMAN
θ value	5.27518 (rank : 65)	NC score	0.014751 (rank : 61)
Query Neighborhood Hits	74	Target Neighborhood Hits	764	Shared Neighborhood Hits	8
SwissProt Accessions	Q92954, Q6DNC4, Q6DNC5, Q6ZMZ5, Q9BX49	Gene names	PRG4, MSF, SZP
Domain Architecture	No domain graphic available
Description	Proteoglycan-4 precursor (Lubricin) (Megakaryocyte-stimulating factor) (Superficial zone proteoglycan) [Contains: Proteoglycan-4 C-terminal part].

ROCK1_MOUSE
θ value	5.27518 (rank : 66)	NC score	0.006032 (rank : 79)
Query Neighborhood Hits	74	Target Neighborhood Hits	2126	Shared Neighborhood Hits	14
SwissProt Accessions	P70335, Q8C3G4, Q8C7H0	Gene names	Rock1
Domain Architecture
Description	Rho-associated protein kinase 1 (EC 2.7.11.1) (Rho-associated, coiled- coil-containing protein kinase 1) (p160 ROCK-1) (p160ROCK).

ATD3B_HUMAN
θ value	6.88961 (rank : 67)	NC score	0.009240 (rank : 70)
Query Neighborhood Hits	74	Target Neighborhood Hits	340	Shared Neighborhood Hits	6
SwissProt Accessions	Q5T9A4, Q6ZRB5, Q9BUK4, Q9ULE7	Gene names	ATAD3B, KIAA1273
Domain Architecture	No domain graphic available
Description	ATPase family AAA domain-containing protein 3B.

CALD1_HUMAN
θ value	6.88961 (rank : 68)	NC score	0.001553 (rank : 82)
Query Neighborhood Hits	74	Target Neighborhood Hits	959	Shared Neighborhood Hits	11
SwissProt Accessions	Q05682, Q13978, Q13979, Q14741, Q14742	Gene names	CALD1, CAD, CDM
Domain Architecture
Description	Caldesmon (CDM).

CT152_HUMAN
θ value	6.88961 (rank : 69)	NC score	0.132862 (rank : 39)
Query Neighborhood Hits	74	Target Neighborhood Hits	30	Shared Neighborhood Hits	26
SwissProt Accessions	Q96M20, Q5T3S1, Q9BR36, Q9BWY5	Gene names	C20orf152
Domain Architecture
Description	Uncharacterized protein C20orf152.

EME1_MOUSE
θ value	6.88961 (rank : 70)	NC score	0.010018 (rank : 66)
Query Neighborhood Hits	74	Target Neighborhood Hits	19	Shared Neighborhood Hits	2
SwissProt Accessions	Q8BJW7	Gene names	Eme1
Domain Architecture	No domain graphic available
Description	Crossover junction endonuclease EME1 (EC 3.1.22.-).

ACINU_MOUSE
θ value	8.99809 (rank : 71)	NC score	0.005435 (rank : 80)
Query Neighborhood Hits	74	Target Neighborhood Hits	712	Shared Neighborhood Hits	9
SwissProt Accessions	Q9JIX8, Q9CSN7, Q9CSR9, Q9CSX7, Q9R046, Q9R047	Gene names	Acin1, Acinus
Domain Architecture
Description	Apoptotic chromatin condensation inducer in the nucleus (Acinus).

KCNA3_MOUSE
θ value	8.99809 (rank : 72)	NC score	0.002798 (rank : 81)
Query Neighborhood Hits	74	Target Neighborhood Hits	103	Shared Neighborhood Hits	3
SwissProt Accessions	P16390	Gene names	Kcna3
Domain Architecture
Description	Potassium voltage-gated channel subfamily A member 3 (Voltage-gated potassium channel subunit Kv1.3) (MK3).

LAD1_MOUSE
θ value	8.99809 (rank : 73)	NC score	0.007588 (rank : 75)
Query Neighborhood Hits	74	Target Neighborhood Hits	391	Shared Neighborhood Hits	10
SwissProt Accessions	P57016	Gene names	Lad1
Domain Architecture	No domain graphic available
Description	Ladinin 1 (Lad-1) (Linear IgA disease autoantigen).

NK1R_MOUSE
θ value	8.99809 (rank : 74)	NC score	-0.003736 (rank : 83)
Query Neighborhood Hits	74	Target Neighborhood Hits	881	Shared Neighborhood Hits	2
SwissProt Accessions	P30548	Gene names	Tacr1, Tac1r
Domain Architecture
Description	Substance-P receptor (SPR) (NK-1 receptor) (NK-1R) (Tachykinin receptor 1).

KCNK2_HUMAN
θ value	θ > 10 (rank : 75)	NC score	0.056933 (rank : 51)
Query Neighborhood Hits	74	Target Neighborhood Hits	86	Shared Neighborhood Hits	15
SwissProt Accessions	O95069, Q9UNE3	Gene names	KCNK2, TREK, TREK1
Domain Architecture	No domain graphic available
Description	Potassium channel subfamily K member 2 (Outward rectifying potassium channel protein TREK-1) (TREK-1 K(+) channel subunit) (Two-pore potassium channel TPKC1).

KCNK2_MOUSE
θ value	θ > 10 (rank : 76)	NC score	0.056519 (rank : 52)
Query Neighborhood Hits	74	Target Neighborhood Hits	88	Shared Neighborhood Hits	15
SwissProt Accessions	P97438	Gene names	Kcnk2
Domain Architecture	No domain graphic available
Description	Potassium channel subfamily K member 2 (Outward rectifying potassium channel protein TREK-1) (Two-pore potassium channel TPKC1) (TREK-1 K(+) channel subunit).

KCNK3_HUMAN
θ value	θ > 10 (rank : 77)	NC score	0.054556 (rank : 54)
Query Neighborhood Hits	74	Target Neighborhood Hits	88	Shared Neighborhood Hits	15
SwissProt Accessions	O14649	Gene names	KCNK3, TASK, TASK1
Domain Architecture
Description	Potassium channel subfamily K member 3 (Acid-sensitive potassium channel protein TASK-1) (TWIK-related acid-sensitive K(+) channel 1) (Two pore potassium channel KT3.1).

KCNK3_MOUSE
θ value	θ > 10 (rank : 78)	NC score	0.052879 (rank : 55)
Query Neighborhood Hits	74	Target Neighborhood Hits	93	Shared Neighborhood Hits	15
SwissProt Accessions	O35111, O35163	Gene names	Kcnk3, Ctbak, Task, Task1
Domain Architecture
Description	Potassium channel subfamily K member 3 (Acid-sensitive potassium channel protein TASK-1) (TWIK-related acid-sensitive K(+) channel 1) (Cardiac two-pore background K(+) channel) (cTBAK-1) (Two pore potassium channel KT3.1).

KCNK6_HUMAN
θ value	θ > 10 (rank : 79)	NC score	0.054994 (rank : 53)
Query Neighborhood Hits	74	Target Neighborhood Hits	79	Shared Neighborhood Hits	14
SwissProt Accessions	Q9Y257, Q9HB47	Gene names	KCNK6, TOSS, TWIK2
Domain Architecture
Description	Potassium channel subfamily K member 6 (Inward rectifying potassium channel protein TWIK-2) (TWIK-originated similarity sequence).

KCNKA_HUMAN
θ value	θ > 10 (rank : 80)	NC score	0.052301 (rank : 56)
Query Neighborhood Hits	74	Target Neighborhood Hits	111	Shared Neighborhood Hits	15
SwissProt Accessions	P57789, Q8TDK7, Q8TDK8, Q9HB59	Gene names	KCNK10, TREK2
Domain Architecture
Description	Potassium channel subfamily K member 10 (Outward rectifying potassium channel protein TREK-2) (TREK-2 K(+) channel subunit).

KCNKF_HUMAN
θ value	θ > 10 (rank : 81)	NC score	0.058266 (rank : 50)
Query Neighborhood Hits	74	Target Neighborhood Hits	87	Shared Neighborhood Hits	15
SwissProt Accessions	Q9H427, Q9HBC8	Gene names	KCNK15, TASK5
Domain Architecture
Description	Potassium channel subfamily K member 15 (Acid-sensitive potassium channel protein TASK-5) (TWIK-related acid-sensitive K(+) channel 5) (Two pore potassium channel KT3.3).

KCNKH_HUMAN
θ value	θ > 10 (rank : 82)	NC score	0.087324 (rank : 43)
Query Neighborhood Hits	74	Target Neighborhood Hits	89	Shared Neighborhood Hits	15
SwissProt Accessions	Q96T54, Q5TCF4, Q8TAW4, Q9BXD1, Q9H592	Gene names	KCNK17, TALK2, TASK4
Domain Architecture
Description	Potassium channel subfamily K member 17 (TWIK-related alkaline pH- activated K(+) channel 2) (2P domain potassium channel Talk-2) (TWIK- related acid-sensitive K(+) channel 4) (TASK-4).

RPGF3_HUMAN
θ value	θ > 10 (rank : 83)	NC score	0.083191 (rank : 44)
Query Neighborhood Hits	74	Target Neighborhood Hits	56	Shared Neighborhood Hits	24
SwissProt Accessions	O95398, O95634, Q8WVN0	Gene names	RAPGEF3, CGEF1, EPAC, EPAC1
Domain Architecture
Description	Rap guanine nucleotide exchange factor 3 (cAMP-regulated guanine nucleotide exchange factor I) (cAMP-GEFI) (Exchange factor directly activated by cAMP 1) (Epac 1) (Rap1 guanine-nucleotide-exchange factor directly activated by cAMP).

Hits sorted by NC score

CNGB3_MOUSE
NC score	0.999962 (rank : 1)	θ value	0 (rank : 2)
Query Neighborhood Hits	74	Target Neighborhood Hits	74	Shared Neighborhood Hits	74
SwissProt Accessions	Q9JJZ9	Gene names	Cngb3, Cng6
Domain Architecture
Description	Cyclic nucleotide-gated cation channel beta 3 (CNG channel beta 3) (Cyclic nucleotide-gated channel beta 3) (Cone photoreceptor cGMP- gated channel subunit beta) (Cyclic nucleotide-gated cation channel modulatory subunit) (Cyclic nucleotide-gated channel subunit CNG6).

CNGB3_HUMAN
NC score	0.981723 (rank : 2)	θ value	0 (rank : 1)
Query Neighborhood Hits	74	Target Neighborhood Hits	206	Shared Neighborhood Hits	50
SwissProt Accessions	Q9NQW8, Q9NRE9	Gene names	CNGB3
Domain Architecture
Description	Cyclic nucleotide-gated cation channel beta 3 (CNG channel beta 3) (Cyclic nucleotide-gated channel beta 3) (Cone photoreceptor cGMP- gated channel subunit beta) (Cyclic nucleotide-gated cation channel modulatory subunit).

CNGB1_HUMAN
NC score	0.967749 (rank : 3)	θ value	2.7506e-174 (rank : 3)
Query Neighborhood Hits	74	Target Neighborhood Hits	222	Shared Neighborhood Hits	49
SwissProt Accessions	Q14028, Q14029	Gene names	CNGB1, CNCG4
Domain Architecture
Description	Cyclic nucleotide-gated cation channel 4 (CNG channel 4) (CNG-4) (CNG4) (Cyclic nucleotide-gated cation channel modulatory subunit).

CNGA3_MOUSE
NC score	0.945191 (rank : 4)	θ value	6.10265e-73 (rank : 7)
Query Neighborhood Hits	74	Target Neighborhood Hits	84	Shared Neighborhood Hits	43
SwissProt Accessions	Q9JJZ8, Q9WV01	Gene names	Cnga3, Cng3
Domain Architecture
Description	Cyclic nucleotide-gated cation channel alpha 3 (CNG channel alpha 3) (CNG-3) (CNG3) (Cyclic nucleotide-gated channel alpha 3) (Cone photoreceptor cGMP-gated channel subunit alpha).

CNGA2_MOUSE
NC score	0.944876 (rank : 5)	θ value	2.39424e-77 (rank : 6)
Query Neighborhood Hits	74	Target Neighborhood Hits	86	Shared Neighborhood Hits	44
SwissProt Accessions	Q62398	Gene names	Cnga2, Cncg2, Cncg4
Domain Architecture
Description	Cyclic nucleotide-gated olfactory channel (Cyclic nucleotide-gated cation channel 2) (CNG channel 2) (CNG-2) (CNG2).

CNGA1_HUMAN
NC score	0.941495 (rank : 6)	θ value	8.22888e-78 (rank : 5)
Query Neighborhood Hits	74	Target Neighborhood Hits	149	Shared Neighborhood Hits	46
SwissProt Accessions	P29973, Q16279, Q16485	Gene names	CNGA1, CNCG, CNCG1
Domain Architecture
Description	cGMP-gated cation channel alpha 1 (CNG channel alpha 1) (CNG-1) (CNG1) (Cyclic nucleotide-gated channel alpha 1) (Cyclic nucleotide-gated channel, photoreceptor) (Cyclic nucleotide-gated cation channel 1) (Rod photoreceptor cGMP-gated channel subunit alpha).

CNGA3_HUMAN
NC score	0.941061 (rank : 7)	θ value	1.15091e-71 (rank : 8)
Query Neighborhood Hits	74	Target Neighborhood Hits	125	Shared Neighborhood Hits	43
SwissProt Accessions	Q16281, Q9UP64	Gene names	CNGA3, CNCG3
Domain Architecture
Description	Cyclic nucleotide-gated cation channel alpha 3 (CNG channel alpha 3) (CNG-3) (CNG3) (Cyclic nucleotide-gated channel alpha 3) (Cone photoreceptor cGMP-gated channel subunit alpha).

CNGA1_MOUSE
NC score	0.938060 (rank : 8)	θ value	2.82823e-78 (rank : 4)
Query Neighborhood Hits	74	Target Neighborhood Hits	198	Shared Neighborhood Hits	48
SwissProt Accessions	P29974, Q60776	Gene names	Cnga1, Cncg, Cncg1
Domain Architecture
Description	cGMP-gated cation channel alpha 1 (CNG channel alpha 1) (CNG-1) (CNG1) (Cyclic nucleotide-gated channel alpha 1) (Cyclic nucleotide-gated channel, photoreceptor) (Cyclic nucleotide-gated cation channel 1) (Rod photoreceptor cGMP-gated channel subunit alpha).

HCN1_HUMAN
NC score	0.836323 (rank : 9)	θ value	1.16434e-31 (rank : 11)
Query Neighborhood Hits	74	Target Neighborhood Hits	120	Shared Neighborhood Hits	44
SwissProt Accessions	O60741	Gene names	HCN1, BCNG1
Domain Architecture
Description	Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1 (Brain cyclic nucleotide-gated channel 1) (BCNG-1).

HCN3_MOUSE
NC score	0.833331 (rank : 10)	θ value	5.40856e-29 (rank : 15)
Query Neighborhood Hits	74	Target Neighborhood Hits	112	Shared Neighborhood Hits	43
SwissProt Accessions	O88705	Gene names	Hcn3, Hac3
Domain Architecture
Description	Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 3 (Hyperpolarization-activated cation channel 3) (HAC-3).

HCN1_MOUSE
NC score	0.832592 (rank : 11)	θ value	1.16434e-31 (rank : 12)
Query Neighborhood Hits	74	Target Neighborhood Hits	172	Shared Neighborhood Hits	44
SwissProt Accessions	O88704, O54899, Q9D613	Gene names	Hcn1, Bcng1, Hac2
Domain Architecture
Description	Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1 (Brain cyclic nucleotide-gated channel 1) (BCNG-1) (Hyperpolarization-activated cation channel 2) (HAC-2).

HCN3_HUMAN
NC score	0.832403 (rank : 12)	θ value	2.68423e-28 (rank : 16)
Query Neighborhood Hits	74	Target Neighborhood Hits	99	Shared Neighborhood Hits	44
SwissProt Accessions	Q9P1Z3, Q4VX12, Q8N6W6, Q9BWQ2	Gene names	HCN3, KIAA1535
Domain Architecture
Description	Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 3.

HCN2_MOUSE
NC score	0.821401 (rank : 13)	θ value	5.40856e-29 (rank : 14)
Query Neighborhood Hits	74	Target Neighborhood Hits	278	Shared Neighborhood Hits	46
SwissProt Accessions	O88703, O70506	Gene names	Hcn2, Bcng2, Hac1
Domain Architecture
Description	Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 (Brain cyclic nucleotide-gated channel 2) (BCNG-2) (Hyperpolarization-activated cation channel 1) (HAC-1).

HCN4_HUMAN
NC score	0.819443 (rank : 14)	θ value	3.06405e-32 (rank : 10)
Query Neighborhood Hits	74	Target Neighborhood Hits	303	Shared Neighborhood Hits	46
SwissProt Accessions	Q9Y3Q4, Q9UMQ7	Gene names	HCN4
Domain Architecture
Description	Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4.

HCN4_MOUSE
NC score	0.818549 (rank : 15)	θ value	1.79631e-32 (rank : 9)
Query Neighborhood Hits	74	Target Neighborhood Hits	284	Shared Neighborhood Hits	46
SwissProt Accessions	O70507	Gene names	Hcn4, Bcng3
Domain Architecture
Description	Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 (Brain cyclic nucleotide-gated channel 3) (BCNG-3).

HCN2_HUMAN
NC score	0.811784 (rank : 16)	θ value	3.17079e-29 (rank : 13)
Query Neighborhood Hits	74	Target Neighborhood Hits	369	Shared Neighborhood Hits	46
SwissProt Accessions	Q9UL51, O60742, O60743, O75267, Q9UBS2	Gene names	HCN2, BCNG2
Domain Architecture
Description	Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 (Brain cyclic nucleotide-gated channel 2) (BCNG-2).

KCNH2_MOUSE
NC score	0.754511 (rank : 17)	θ value	9.87957e-23 (rank : 17)
Query Neighborhood Hits	74	Target Neighborhood Hits	165	Shared Neighborhood Hits	39
SwissProt Accessions	O35219, O35220, O35221, O35989	Gene names	Kcnh2, Erg, Merg1
Domain Architecture
Description	Potassium voltage-gated channel subfamily H member 2 (Voltage-gated potassium channel subunit Kv11.1) (Ether-a-go-go-related gene potassium channel 1) (ERG1) (MERG) (Merg1) (Ether-a-go-go-related protein 1) (Eag-related protein 1).

KCNH2_HUMAN
NC score	0.754483 (rank : 18)	θ value	2.87452e-22 (rank : 18)
Query Neighborhood Hits	74	Target Neighborhood Hits	158	Shared Neighborhood Hits	40
SwissProt Accessions	Q12809, O75418, O75680, Q9BT72, Q9BUT7, Q9H3P0	Gene names	KCNH2, ERG, ERG1, HERG, HERG1
Domain Architecture
Description	Potassium voltage-gated channel subfamily H member 2 (Voltage-gated potassium channel subunit Kv11.1) (Ether-a-go-go-related gene potassium channel 1) (H-ERG) (Erg1) (Ether-a-go-go-related protein 1) (Eag-related protein 1) (eag homolog).

KCNH7_MOUSE
NC score	0.751449 (rank : 19)	θ value	2.5182e-18 (rank : 23)
Query Neighborhood Hits	74	Target Neighborhood Hits	98	Shared Neighborhood Hits	39
SwissProt Accessions	Q9ER47	Gene names	Kcnh7, Erg3
Domain Architecture
Description	Potassium voltage-gated channel subfamily H member 7 (Voltage-gated potassium channel subunit Kv11.3) (Ether-a-go-go-related gene potassium channel 3) (Ether-a-go-go-related protein 3) (Eag-related protein 3).

KCNH6_HUMAN
NC score	0.749129 (rank : 20)	θ value	7.32683e-18 (rank : 25)
Query Neighborhood Hits	74	Target Neighborhood Hits	222	Shared Neighborhood Hits	39
SwissProt Accessions	Q9H252, Q9BRD7	Gene names	KCNH6, ERG2, HERG2
Domain Architecture
Description	Potassium voltage-gated channel subfamily H member 6 (Voltage-gated potassium channel subunit Kv11.2) (Ether-a-go-go-related gene potassium channel 2) (Ether-a-go-go-related protein 2) (Eag-related protein 2).

KCNH7_HUMAN
NC score	0.747367 (rank : 21)	θ value	4.29542e-18 (rank : 24)
Query Neighborhood Hits	74	Target Neighborhood Hits	107	Shared Neighborhood Hits	40
SwissProt Accessions	Q9NS40	Gene names	KCNH7, ERG3
Domain Architecture
Description	Potassium voltage-gated channel subfamily H member 7 (Voltage-gated potassium channel subunit Kv11.3) (Ether-a-go-go-related gene potassium channel 3) (HERG-3) (Ether-a-go-go-related protein 3) (Eag- related protein 3).

KCNH5_MOUSE
NC score	0.745779 (rank : 22)	θ value	3.51386e-20 (rank : 20)
Query Neighborhood Hits	74	Target Neighborhood Hits	102	Shared Neighborhood Hits	34
SwissProt Accessions	Q920E3, Q8C035	Gene names	Kcnh5, Eag2
Domain Architecture	No domain graphic available
Description	Potassium voltage-gated channel subfamily H member 5 (Voltage-gated potassium channel subunit Kv10.2) (Ether-a-go-go potassium channel 2) (Eag2).

KCNH5_HUMAN
NC score	0.745273 (rank : 23)	θ value	3.51386e-20 (rank : 19)
Query Neighborhood Hits	74	Target Neighborhood Hits	99	Shared Neighborhood Hits	33
SwissProt Accessions	Q8NCM2	Gene names	KCNH5, EAG2
Domain Architecture
Description	Potassium voltage-gated channel subfamily H member 5 (Voltage-gated potassium channel subunit Kv10.2) (Ether-a-go-go potassium channel 2) (hEAG2).

KCNH4_HUMAN
NC score	0.743110 (rank : 24)	θ value	8.10077e-17 (rank : 27)
Query Neighborhood Hits	74	Target Neighborhood Hits	177	Shared Neighborhood Hits	33
SwissProt Accessions	Q9UQ05	Gene names	KCNH4
Domain Architecture
Description	Potassium voltage-gated channel subfamily H member 4 (Voltage-gated potassium channel subunit Kv12.3) (Ether-a-go-go-like potassium channel 1) (ELK channel 1) (ELK1) (Brain-specific eag-like channel 2) (BEC2).

KCNH8_HUMAN
NC score	0.741179 (rank : 25)	θ value	9.56915e-18 (rank : 26)
Query Neighborhood Hits	74	Target Neighborhood Hits	104	Shared Neighborhood Hits	34
SwissProt Accessions	Q96L42	Gene names	KCNH8
Domain Architecture
Description	Potassium voltage-gated channel subfamily H member 8 (Voltage-gated potassium channel subunit Kv12.1) (Ether-a-go-go-like potassium channel 3) (ELK channel 3) (ELK3) (ELK1) (hElk1).

KCNH1_MOUSE
NC score	0.739996 (rank : 26)	θ value	1.92812e-18 (rank : 22)
Query Neighborhood Hits	74	Target Neighborhood Hits	94	Shared Neighborhood Hits	38
SwissProt Accessions	Q60603	Gene names	Kcnh1, Eag
Domain Architecture
Description	Potassium voltage-gated channel subfamily H member 1 (Voltage-gated potassium channel subunit Kv10.1) (Ether-a-go-go potassium channel 1) (EAG1) (m-eag).

KCNH1_HUMAN
NC score	0.739798 (rank : 27)	θ value	1.92812e-18 (rank : 21)
Query Neighborhood Hits	74	Target Neighborhood Hits	98	Shared Neighborhood Hits	38
SwissProt Accessions	O95259, O76035	Gene names	KCNH1, EAG, EAG1
Domain Architecture
Description	Potassium voltage-gated channel subfamily H member 1 (Voltage-gated potassium channel subunit Kv10.1) (Ether-a-go-go potassium channel 1) (hEAG1) (h-eag).

KCNH3_HUMAN
NC score	0.727910 (rank : 28)	θ value	4.91457e-14 (rank : 28)
Query Neighborhood Hits	74	Target Neighborhood Hits	148	Shared Neighborhood Hits	34
SwissProt Accessions	Q9ULD8, Q9UQ06	Gene names	KCNH3, KIAA1282
Domain Architecture
Description	Potassium voltage-gated channel subfamily H member 3 (Voltage-gated potassium channel subunit Kv12.2) (Ether-a-go-go-like potassium channel 2) (ELK channel 2) (ELK2) (Brain-specific eag-like channel 1) (BEC1).

KCNH3_MOUSE
NC score	0.726821 (rank : 29)	θ value	5.43371e-13 (rank : 29)
Query Neighborhood Hits	74	Target Neighborhood Hits	133	Shared Neighborhood Hits	33
SwissProt Accessions	Q9WVJ0	Gene names	Kcnh3, Elk2
Domain Architecture
Description	Potassium voltage-gated channel subfamily H member 3 (Voltage-gated potassium channel subunit Kv12.2) (Ether-a-go-go-like potassium channel 2) (ELK channel 2) (mElk2).

KAP0_HUMAN
NC score	0.294649 (rank : 30)	θ value	0.00134147 (rank : 32)
Query Neighborhood Hits	74	Target Neighborhood Hits	52	Shared Neighborhood Hits	41
SwissProt Accessions	P10644, Q567S7	Gene names	PRKAR1A, PKR1, PRKAR1
Domain Architecture
Description	cAMP-dependent protein kinase type I-alpha regulatory subunit (Tissue- specific extinguisher 1) (TSE1).

KAP1_HUMAN
NC score	0.276654 (rank : 31)	θ value	0.0113563 (rank : 40)
Query Neighborhood Hits	74	Target Neighborhood Hits	58	Shared Neighborhood Hits	39
SwissProt Accessions	P31321	Gene names	PRKAR1B
Domain Architecture
Description	cAMP-dependent protein kinase type I-beta regulatory subunit.

KAP0_MOUSE
NC score	0.276288 (rank : 32)	θ value	0.00390308 (rank : 34)
Query Neighborhood Hits	74	Target Neighborhood Hits	48	Shared Neighborhood Hits	41
SwissProt Accessions	Q9DBC7, Q3UKU7, Q9JHR5, Q9JHR6	Gene names	Prkar1a
Domain Architecture	No domain graphic available
Description	cAMP-dependent protein kinase type I-alpha regulatory subunit.

KAP1_MOUSE
NC score	0.272317 (rank : 33)	θ value	0.00869519 (rank : 39)
Query Neighborhood Hits	74	Target Neighborhood Hits	49	Shared Neighborhood Hits	39
SwissProt Accessions	P12849	Gene names	Prkar1b
Domain Architecture
Description	cAMP-dependent protein kinase type I-beta regulatory subunit.

KAP2_MOUSE
NC score	0.238252 (rank : 34)	θ value	0.00665767 (rank : 36)
Query Neighborhood Hits	74	Target Neighborhood Hits	44	Shared Neighborhood Hits	31
SwissProt Accessions	P12367	Gene names	Prkar2a
Domain Architecture
Description	cAMP-dependent protein kinase type II-alpha regulatory subunit.

KAP2_HUMAN
NC score	0.235175 (rank : 35)	θ value	0.00665767 (rank : 35)
Query Neighborhood Hits	74	Target Neighborhood Hits	48	Shared Neighborhood Hits	31
SwissProt Accessions	P13861, Q16823	Gene names	PRKAR2A, PKR2, PRKAR2
Domain Architecture
Description	cAMP-dependent protein kinase type II-alpha regulatory subunit.

KAP3_MOUSE
NC score	0.234357 (rank : 36)	θ value	0.365318 (rank : 47)
Query Neighborhood Hits	74	Target Neighborhood Hits	43	Shared Neighborhood Hits	33
SwissProt Accessions	P31324, Q3UTZ1, Q80ZM4, Q8BRZ7	Gene names	Prkar2b
Domain Architecture	No domain graphic available
Description	cAMP-dependent protein kinase type II-beta regulatory subunit.

KAP3_HUMAN
NC score	0.229313 (rank : 37)	θ value	0.365318 (rank : 46)
Query Neighborhood Hits	74	Target Neighborhood Hits	40	Shared Neighborhood Hits	33
SwissProt Accessions	P31323	Gene names	PRKAR2B
Domain Architecture
Description	cAMP-dependent protein kinase type II-beta regulatory subunit.

CT152_MOUSE
NC score	0.180402 (rank : 38)	θ value	0.62314 (rank : 48)
Query Neighborhood Hits	74	Target Neighborhood Hits	38	Shared Neighborhood Hits	34
SwissProt Accessions	Q9D5U8, Q8R083	Gene names
Domain Architecture
Description	Uncharacterized protein C20orf152 homolog.

CT152_HUMAN
NC score	0.132862 (rank : 39)	θ value	6.88961 (rank : 69)
Query Neighborhood Hits	74	Target Neighborhood Hits	30	Shared Neighborhood Hits	26
SwissProt Accessions	Q96M20, Q5T3S1, Q9BR36, Q9BWY5	Gene names	C20orf152
Domain Architecture
Description	Uncharacterized protein C20orf152.

RPGF4_MOUSE
NC score	0.104582 (rank : 40)	θ value	0.0961366 (rank : 42)
Query Neighborhood Hits	74	Target Neighborhood Hits	80	Shared Neighborhood Hits	30
SwissProt Accessions	Q9EQZ6, Q8VIP9, Q9CW52, Q9Z1P0	Gene names	Rapgef4, Cgef2, Epac2
Domain Architecture
Description	Rap guanine nucleotide exchange factor 4 (cAMP-regulated guanine nucleotide exchange factor II) (cAMP-GEFII) (Exchange factor directly activated by cAMP 2) (Epac 2) (cAMP-dependent Rap1 guanine-nucleotide exchange factor).

RPGF4_HUMAN
NC score	0.100125 (rank : 41)	θ value	0.279714 (rank : 45)
Query Neighborhood Hits	74	Target Neighborhood Hits	88	Shared Neighborhood Hits	30
SwissProt Accessions	Q8WZA2, O95636, Q8IXK6, Q8TAA4	Gene names	RAPGEF4, CGEF2, EPAC2
Domain Architecture
Description	Rap guanine nucleotide exchange factor 4 (cAMP-regulated guanine nucleotide exchange factor II) (cAMP-GEFII) (Exchange factor directly activated by cAMP 2) (Epac 2).

RPGF3_MOUSE
NC score	0.096105 (rank : 42)	θ value	0.0330416 (rank : 41)
Query Neighborhood Hits	74	Target Neighborhood Hits	54	Shared Neighborhood Hits	24
SwissProt Accessions	Q8VCC8, Q8BZK9, Q8R1R1	Gene names	Rapgef3, Epac, Epac1
Domain Architecture
Description	Rap guanine nucleotide exchange factor 3 (cAMP-regulated guanine nucleotide exchange factor I) (cAMP-GEFI) (Exchange factor directly activated by cAMP 1) (Epac 1).

KCNKH_HUMAN
NC score	0.087324 (rank : 43)	θ value	θ > 10 (rank : 82)
Query Neighborhood Hits	74	Target Neighborhood Hits	89	Shared Neighborhood Hits	15
SwissProt Accessions	Q96T54, Q5TCF4, Q8TAW4, Q9BXD1, Q9H592	Gene names	KCNK17, TALK2, TASK4
Domain Architecture
Description	Potassium channel subfamily K member 17 (TWIK-related alkaline pH- activated K(+) channel 2) (2P domain potassium channel Talk-2) (TWIK- related acid-sensitive K(+) channel 4) (TASK-4).

RPGF3_HUMAN
NC score	0.083191 (rank : 44)	θ value	θ > 10 (rank : 83)
Query Neighborhood Hits	74	Target Neighborhood Hits	56	Shared Neighborhood Hits	24
SwissProt Accessions	O95398, O95634, Q8WVN0	Gene names	RAPGEF3, CGEF1, EPAC, EPAC1
Domain Architecture
Description	Rap guanine nucleotide exchange factor 3 (cAMP-regulated guanine nucleotide exchange factor I) (cAMP-GEFI) (Exchange factor directly activated by cAMP 1) (Epac 1) (Rap1 guanine-nucleotide-exchange factor directly activated by cAMP).

KGP2_HUMAN
NC score	0.080352 (rank : 45)	θ value	0.000121331 (rank : 30)
Query Neighborhood Hits	74	Target Neighborhood Hits	1023	Shared Neighborhood Hits	41
SwissProt Accessions	Q13237, O00125, O60916	Gene names	PRKG2, PRKGR2
Domain Architecture
Description	cGMP-dependent protein kinase 2 (EC 2.7.11.12) (CGK 2) (cGKII) (Type II cGMP-dependent protein kinase).

KGP2_MOUSE
NC score	0.080025 (rank : 46)	θ value	0.000121331 (rank : 31)
Query Neighborhood Hits	74	Target Neighborhood Hits	1029	Shared Neighborhood Hits	40
SwissProt Accessions	Q61410	Gene names	Prkg2, Prkgr2
Domain Architecture
Description	cGMP-dependent protein kinase 2 (EC 2.7.11.12) (CGK 2) (cGKII) (Type II cGMP-dependent protein kinase).

KGP1B_MOUSE
NC score	0.079794 (rank : 47)	θ value	0.00298849 (rank : 33)
Query Neighborhood Hits	74	Target Neighborhood Hits	922	Shared Neighborhood Hits	49
SwissProt Accessions	Q9Z0Z0	Gene names	Prkg1, Prkg1b, Prkgr1b
Domain Architecture
Description	cGMP-dependent protein kinase 1, beta isozyme (EC 2.7.11.12) (cGK 1 beta) (cGKI-beta).

KGP1B_HUMAN
NC score	0.079247 (rank : 48)	θ value	0.00665767 (rank : 38)
Query Neighborhood Hits	74	Target Neighborhood Hits	921	Shared Neighborhood Hits	49
SwissProt Accessions	P14619	Gene names	PRKG1, PRKG1B, PRKGR1B
Domain Architecture
Description	cGMP-dependent protein kinase 1, beta isozyme (EC 2.7.11.12) (cGK 1 beta) (cGKI-beta).

KGP1A_HUMAN
NC score	0.078889 (rank : 49)	θ value	0.00665767 (rank : 37)
Query Neighborhood Hits	74	Target Neighborhood Hits	901	Shared Neighborhood Hits	49
SwissProt Accessions	Q13976	Gene names	PRKG1, PRKGR1A
Domain Architecture
Description	cGMP-dependent protein kinase 1, alpha isozyme (EC 2.7.11.12) (CGK 1 alpha) (cGKI-alpha).

KCNKF_HUMAN
NC score	0.058266 (rank : 50)	θ value	θ > 10 (rank : 81)
Query Neighborhood Hits	74	Target Neighborhood Hits	87	Shared Neighborhood Hits	15
SwissProt Accessions	Q9H427, Q9HBC8	Gene names	KCNK15, TASK5
Domain Architecture
Description	Potassium channel subfamily K member 15 (Acid-sensitive potassium channel protein TASK-5) (TWIK-related acid-sensitive K(+) channel 5) (Two pore potassium channel KT3.3).

KCNK2_HUMAN
NC score	0.056933 (rank : 51)	θ value	θ > 10 (rank : 75)
Query Neighborhood Hits	74	Target Neighborhood Hits	86	Shared Neighborhood Hits	15
SwissProt Accessions	O95069, Q9UNE3	Gene names	KCNK2, TREK, TREK1
Domain Architecture	No domain graphic available
Description	Potassium channel subfamily K member 2 (Outward rectifying potassium channel protein TREK-1) (TREK-1 K(+) channel subunit) (Two-pore potassium channel TPKC1).

KCNK2_MOUSE
NC score	0.056519 (rank : 52)	θ value	θ > 10 (rank : 76)
Query Neighborhood Hits	74	Target Neighborhood Hits	88	Shared Neighborhood Hits	15
SwissProt Accessions	P97438	Gene names	Kcnk2
Domain Architecture	No domain graphic available
Description	Potassium channel subfamily K member 2 (Outward rectifying potassium channel protein TREK-1) (Two-pore potassium channel TPKC1) (TREK-1 K(+) channel subunit).

KCNK6_HUMAN
NC score	0.054994 (rank : 53)	θ value	θ > 10 (rank : 79)
Query Neighborhood Hits	74	Target Neighborhood Hits	79	Shared Neighborhood Hits	14
SwissProt Accessions	Q9Y257, Q9HB47	Gene names	KCNK6, TOSS, TWIK2
Domain Architecture
Description	Potassium channel subfamily K member 6 (Inward rectifying potassium channel protein TWIK-2) (TWIK-originated similarity sequence).

KCNK3_HUMAN
NC score	0.054556 (rank : 54)	θ value	θ > 10 (rank : 77)
Query Neighborhood Hits	74	Target Neighborhood Hits	88	Shared Neighborhood Hits	15
SwissProt Accessions	O14649	Gene names	KCNK3, TASK, TASK1
Domain Architecture
Description	Potassium channel subfamily K member 3 (Acid-sensitive potassium channel protein TASK-1) (TWIK-related acid-sensitive K(+) channel 1) (Two pore potassium channel KT3.1).

KCNK3_MOUSE
NC score	0.052879 (rank : 55)	θ value	θ > 10 (rank : 78)
Query Neighborhood Hits	74	Target Neighborhood Hits	93	Shared Neighborhood Hits	15
SwissProt Accessions	O35111, O35163	Gene names	Kcnk3, Ctbak, Task, Task1
Domain Architecture
Description	Potassium channel subfamily K member 3 (Acid-sensitive potassium channel protein TASK-1) (TWIK-related acid-sensitive K(+) channel 1) (Cardiac two-pore background K(+) channel) (cTBAK-1) (Two pore potassium channel KT3.1).

KCNKA_HUMAN
NC score	0.052301 (rank : 56)	θ value	θ > 10 (rank : 80)
Query Neighborhood Hits	74	Target Neighborhood Hits	111	Shared Neighborhood Hits	15
SwissProt Accessions	P57789, Q8TDK7, Q8TDK8, Q9HB59	Gene names	KCNK10, TREK2
Domain Architecture
Description	Potassium channel subfamily K member 10 (Outward rectifying potassium channel protein TREK-2) (TREK-2 K(+) channel subunit).

NFH_MOUSE
NC score	0.022437 (rank : 57)	θ value	5.27518 (rank : 62)
Query Neighborhood Hits	74	Target Neighborhood Hits	2247	Shared Neighborhood Hits	31
SwissProt Accessions	P19246, Q5SVF6, Q61959	Gene names	Nefh, Nfh
Domain Architecture
Description	Neurofilament triplet H protein (200 kDa neurofilament protein) (Neurofilament heavy polypeptide) (NF-H).

TTF2_HUMAN
NC score	0.017910 (rank : 58)	θ value	0.0961366 (rank : 43)
Query Neighborhood Hits	74	Target Neighborhood Hits	98	Shared Neighborhood Hits	2
SwissProt Accessions	Q9UNY4, O75921, Q5T2K7, Q5VVU8, Q8N6I8	Gene names	TTF2
Domain Architecture	No domain graphic available
Description	Transcription termination factor 2 (EC 3.6.1.-) (RNA polymerase II termination factor) (Transcription release factor 2) (Factor 2) (F2) (HuF2) (Lodestar homolog).

MAP1B_MOUSE
NC score	0.016089 (rank : 59)	θ value	5.27518 (rank : 61)
Query Neighborhood Hits	74	Target Neighborhood Hits	977	Shared Neighborhood Hits	17
SwissProt Accessions	P14873	Gene names	Map1b, Mtap1b, Mtap5
Domain Architecture	No domain graphic available
Description	Microtubule-associated protein 1B (MAP 1B) (MAP1.2) (MAP1(X)) [Contains: MAP1 light chain LC1].

NHS_HUMAN
NC score	0.014757 (rank : 60)	θ value	4.03905 (rank : 57)
Query Neighborhood Hits	74	Target Neighborhood Hits	198	Shared Neighborhood Hits	3
SwissProt Accessions	Q6T4R5, Q5J7Q0, Q5J7Q1, Q68DR5	Gene names	NHS
Domain Architecture	No domain graphic available
Description	Nance-Horan syndrome protein (Congenital cataracts and dental anomalies protein).

PRG4_HUMAN
NC score	0.014751 (rank : 61)	θ value	5.27518 (rank : 65)
Query Neighborhood Hits	74	Target Neighborhood Hits	764	Shared Neighborhood Hits	8
SwissProt Accessions	Q92954, Q6DNC4, Q6DNC5, Q6ZMZ5, Q9BX49	Gene names	PRG4, MSF, SZP
Domain Architecture	No domain graphic available
Description	Proteoglycan-4 precursor (Lubricin) (Megakaryocyte-stimulating factor) (Superficial zone proteoglycan) [Contains: Proteoglycan-4 C-terminal part].

AFF1_MOUSE
NC score	0.014458 (rank : 62)	θ value	4.03905 (rank : 54)
Query Neighborhood Hits	74	Target Neighborhood Hits	351	Shared Neighborhood Hits	7
SwissProt Accessions	O88573	Gene names	Aff1, Mllt2, Mllt2h
Domain Architecture
Description	AF4/FMR2 family member 1 (Protein AF-4) (Proto-oncogene AF4).

PSMD2_MOUSE
NC score	0.013513 (rank : 63)	θ value	4.03905 (rank : 58)
Query Neighborhood Hits	74	Target Neighborhood Hits	147	Shared Neighborhood Hits	4
SwissProt Accessions	Q8VDM4	Gene names	Psmd2
Domain Architecture	No domain graphic available
Description	26S proteasome non-ATPase regulatory subunit 2 (26S proteasome regulatory subunit RPN1) (26S proteasome regulatory subunit S2) (26S proteasome subunit p97).

ATAD3_MOUSE
NC score	0.012946 (rank : 64)	θ value	1.38821 (rank : 49)
Query Neighborhood Hits	74	Target Neighborhood Hits	326	Shared Neighborhood Hits	5
SwissProt Accessions	Q925I1, Q3UE74, Q69ZM7, Q8C6C6	Gene names	Atad3, Atad3a, Kiaa1273
Domain Architecture	No domain graphic available
Description	ATPase family AAA domain-containing protein 3 (AAA-ATPase TOB3).

PKHA5_HUMAN
NC score	0.010427 (rank : 65)	θ value	5.27518 (rank : 64)
Query Neighborhood Hits	74	Target Neighborhood Hits	455	Shared Neighborhood Hits	11
SwissProt Accessions	Q9HAU0, Q8N3K6, Q96DY9, Q9BVR4, Q9C0H7, Q9H924, Q9NVK8	Gene names	PLEKHA5, KIAA1686, PEPP2
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 5 (Phosphoinositol 3-phosphate-binding protein 2) (PEPP-2).

EME1_MOUSE
NC score	0.010018 (rank : 66)	θ value	6.88961 (rank : 70)
Query Neighborhood Hits	74	Target Neighborhood Hits	19	Shared Neighborhood Hits	2
SwissProt Accessions	Q8BJW7	Gene names	Eme1
Domain Architecture	No domain graphic available
Description	Crossover junction endonuclease EME1 (EC 3.1.22.-).

BPAEA_HUMAN
NC score	0.009800 (rank : 67)	θ value	0.163984 (rank : 44)
Query Neighborhood Hits	74	Target Neighborhood Hits	1369	Shared Neighborhood Hits	13
SwissProt Accessions	O94833, Q5TBT0, Q8N1T8, Q8N8J3, Q8WXK9, Q96AK9, Q96DQ5, Q9H555	Gene names	DST, BPAG1, DMH, DT, KIAA0728
Domain Architecture
Description	Bullous pemphigoid antigen 1, isoforms 6/9/10 (Trabeculin-beta) (Bullous pemphigoid antigen) (BPA) (Hemidesmosomal plaque protein) (Dystonia musculorum protein) (Dystonin).

DVL3_MOUSE
NC score	0.009634 (rank : 68)	θ value	2.36792 (rank : 51)
Query Neighborhood Hits	74	Target Neighborhood Hits	198	Shared Neighborhood Hits	5
SwissProt Accessions	Q61062	Gene names	Dvl3
Domain Architecture
Description	Segment polarity protein dishevelled homolog DVL-3 (Dishevelled-3) (DSH homolog 3).

NOP56_MOUSE
NC score	0.009435 (rank : 69)	θ value	5.27518 (rank : 63)
Query Neighborhood Hits	74	Target Neighborhood Hits	129	Shared Neighborhood Hits	5
SwissProt Accessions	Q9D6Z1, Q3UD45, Q8BVL1, Q8VDT2, Q99LT8, Q9CT15	Gene names	Nol5a, Nop56
Domain Architecture
Description	Nucleolar protein Nop56 (Nucleolar protein 5A).

ATD3B_HUMAN
NC score	0.009240 (rank : 70)	θ value	6.88961 (rank : 67)
Query Neighborhood Hits	74	Target Neighborhood Hits	340	Shared Neighborhood Hits	6
SwissProt Accessions	Q5T9A4, Q6ZRB5, Q9BUK4, Q9ULE7	Gene names	ATAD3B, KIAA1273
Domain Architecture	No domain graphic available
Description	ATPase family AAA domain-containing protein 3B.

RSF1_HUMAN
NC score	0.008910 (rank : 71)	θ value	3.0926 (rank : 53)
Query Neighborhood Hits	74	Target Neighborhood Hits	539	Shared Neighborhood Hits	8
SwissProt Accessions	Q96T23, Q86X86, Q9H3L8, Q9NVZ8, Q9NYU0	Gene names	RSF1, HBXAP, XAP8
Domain Architecture	No domain graphic available
Description	Remodeling and spacing factor 1 (Rsf-1) (Hepatitis B virus X- associated protein) (HBV pX-associated protein 8) (p325 subunit of RSF chromatin remodelling complex).

KCNF1_HUMAN
NC score	0.008729 (rank : 72)	θ value	1.81305 (rank : 50)
Query Neighborhood Hits	74	Target Neighborhood Hits	109	Shared Neighborhood Hits	8
SwissProt Accessions	Q9H3M0, O43527	Gene names	KCNF1
Domain Architecture
Description	Potassium voltage-gated channel subfamily F member 1 (Voltage-gated potassium channel subunit Kv5.1) (kH1).

CCNB3_MOUSE
NC score	0.008420 (rank : 73)	θ value	4.03905 (rank : 55)
Query Neighborhood Hits	74	Target Neighborhood Hits	211	Shared Neighborhood Hits	7
SwissProt Accessions	Q810T2, Q810T3, Q8VDC8	Gene names	Ccnb3, Cycb3
Domain Architecture
Description	G2/mitotic-specific cyclin-B3.

SETD2_HUMAN
NC score	0.007987 (rank : 74)	θ value	4.03905 (rank : 59)
Query Neighborhood Hits	74	Target Neighborhood Hits	412	Shared Neighborhood Hits	7
SwissProt Accessions	Q9BYW2, O75397, O75405, Q17RW8, Q5BKS9, Q5QGN2, Q69YI5, Q6IN64, Q6ZN53, Q6ZS25, Q8N3R0, Q8TCN0, Q9C0D1, Q9H696, Q9NZW9	Gene names	SETD2, HIF1, HYPB, KIAA1732, SET2
Domain Architecture	No domain graphic available
Description	Histone-lysine N-methyltransferase, H3 lysine-36-specific (EC 2.1.1.43) (SET domain-containing protein 2) (hSET2) (Huntingtin- interacting protein HYPB) (Huntingtin-interacting protein 1) (HIF-1) (p231HBP).

LAD1_MOUSE
NC score	0.007588 (rank : 75)	θ value	8.99809 (rank : 73)
Query Neighborhood Hits	74	Target Neighborhood Hits	391	Shared Neighborhood Hits	10
SwissProt Accessions	P57016	Gene names	Lad1
Domain Architecture	No domain graphic available
Description	Ladinin 1 (Lad-1) (Linear IgA disease autoantigen).

ROCK2_MOUSE
NC score	0.006947 (rank : 76)	θ value	2.36792 (rank : 52)
Query Neighborhood Hits	74	Target Neighborhood Hits	2072	Shared Neighborhood Hits	18
SwissProt Accessions	P70336, Q8BR64, Q8CBR0	Gene names	Rock2
Domain Architecture
Description	Rho-associated protein kinase 2 (EC 2.7.11.1) (Rho-associated, coiled- coil-containing protein kinase 2) (p164 ROCK-2).

MIPO1_HUMAN
NC score	0.006908 (rank : 77)	θ value	4.03905 (rank : 56)
Query Neighborhood Hits	74	Target Neighborhood Hits	486	Shared Neighborhood Hits	7
SwissProt Accessions	Q8TD10, Q7Z3J0, Q8IV14	Gene names	MIPOL1
Domain Architecture	No domain graphic available
Description	Mirror-image polydactyly gene 1 protein.

UBP37_HUMAN
NC score	0.006295 (rank : 78)	θ value	4.03905 (rank : 60)
Query Neighborhood Hits	74	Target Neighborhood Hits	208	Shared Neighborhood Hits	3
SwissProt Accessions	Q86T82, Q9HCH8	Gene names	USP37, KIAA1594
Domain Architecture
Description	Ubiquitin carboxyl-terminal hydrolase 37 (EC 3.1.2.15) (Ubiquitin thioesterase 37) (Ubiquitin-specific-processing protease 37) (Deubiquitinating enzyme 37).

ROCK1_MOUSE
NC score	0.006032 (rank : 79)	θ value	5.27518 (rank : 66)
Query Neighborhood Hits	74	Target Neighborhood Hits	2126	Shared Neighborhood Hits	14
SwissProt Accessions	P70335, Q8C3G4, Q8C7H0	Gene names	Rock1
Domain Architecture
Description	Rho-associated protein kinase 1 (EC 2.7.11.1) (Rho-associated, coiled- coil-containing protein kinase 1) (p160 ROCK-1) (p160ROCK).

ACINU_MOUSE
NC score	0.005435 (rank : 80)	θ value	8.99809 (rank : 71)
Query Neighborhood Hits	74	Target Neighborhood Hits	712	Shared Neighborhood Hits	9
SwissProt Accessions	Q9JIX8, Q9CSN7, Q9CSR9, Q9CSX7, Q9R046, Q9R047	Gene names	Acin1, Acinus
Domain Architecture
Description	Apoptotic chromatin condensation inducer in the nucleus (Acinus).

KCNA3_MOUSE
NC score	0.002798 (rank : 81)	θ value	8.99809 (rank : 72)
Query Neighborhood Hits	74	Target Neighborhood Hits	103	Shared Neighborhood Hits	3
SwissProt Accessions	P16390	Gene names	Kcna3
Domain Architecture
Description	Potassium voltage-gated channel subfamily A member 3 (Voltage-gated potassium channel subunit Kv1.3) (MK3).

CALD1_HUMAN
NC score	0.001553 (rank : 82)	θ value	6.88961 (rank : 68)
Query Neighborhood Hits	74	Target Neighborhood Hits	959	Shared Neighborhood Hits	11
SwissProt Accessions	Q05682, Q13978, Q13979, Q14741, Q14742	Gene names	CALD1, CAD, CDM
Domain Architecture
Description	Caldesmon (CDM).

NK1R_MOUSE
NC score	-0.003736 (rank : 83)	θ value	8.99809 (rank : 74)
Query Neighborhood Hits	74	Target Neighborhood Hits	881	Shared Neighborhood Hits	2
SwissProt Accessions	P30548	Gene names	Tacr1, Tac1r
Domain Architecture
Description	Substance-P receptor (SPR) (NK-1 receptor) (NK-1R) (Tachykinin receptor 1).