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Network neighborhood for query Sequence : GRIK5_HUMAN

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GRIK5_HUMAN
SwissProt Accessions	Q16478	Gene names	GRIK5, GRIK2
Domain Architecture
Description	Glutamate receptor, ionotropic kainate 5 precursor (Glutamate receptor KA-2) (KA2) (Excitatory amino acid receptor 2) (EAA2).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

GRIK1_HUMAN
θ value	0 (rank : 1)	NC score	0.985776 (rank : 7)
Query Neighborhood Hits	44	Target Neighborhood Hits	48	Shared Neighborhood Hits	33
SwissProt Accessions	P39086, Q13001, Q86SU9	Gene names	GRIK1, GLUR5
Domain Architecture
Description	Glutamate receptor, ionotropic kainate 1 precursor (Glutamate receptor 5) (GluR-5) (GluR5) (Excitatory amino acid receptor 3) (EAA3).

GRIK2_HUMAN
θ value	0 (rank : 2)	NC score	0.987016 (rank : 6)
Query Neighborhood Hits	44	Target Neighborhood Hits	50	Shared Neighborhood Hits	33
SwissProt Accessions	Q13002	Gene names	GRIK2, GLUR6
Domain Architecture
Description	Glutamate receptor, ionotropic kainate 2 precursor (Glutamate receptor 6) (GluR-6) (GluR6) (Excitatory amino acid receptor 4) (EAA4).

GRIK3_HUMAN
θ value	0 (rank : 3)	NC score	0.988528 (rank : 5)
Query Neighborhood Hits	44	Target Neighborhood Hits	41	Shared Neighborhood Hits	33
SwissProt Accessions	Q13003, Q13004, Q16136	Gene names	GRIK3, GLUR7
Domain Architecture
Description	Glutamate receptor, ionotropic kainate 3 precursor (Glutamate receptor 7) (GluR-7) (GluR7) (Excitatory amino acid receptor 5) (EAA5).

GRIK4_HUMAN
θ value	0 (rank : 4)	NC score	0.998309 (rank : 4)
Query Neighborhood Hits	44	Target Neighborhood Hits	42	Shared Neighborhood Hits	33
SwissProt Accessions	Q16099	Gene names	GRIK4, GRIK
Domain Architecture
Description	Glutamate receptor, ionotropic kainate 4 precursor (Glutamate receptor KA-1) (KA1) (Excitatory amino acid receptor 1) (EAA1).

GRIK4_MOUSE
θ value	0 (rank : 5)	NC score	0.998372 (rank : 3)
Query Neighborhood Hits	44	Target Neighborhood Hits	41	Shared Neighborhood Hits	33
SwissProt Accessions	Q8BMF5	Gene names	Grik4
Domain Architecture	No domain graphic available
Description	Glutamate receptor, ionotropic kainate 4 precursor.

GRIK5_HUMAN
θ value	0 (rank : 6)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	44	Target Neighborhood Hits	44	Shared Neighborhood Hits	44
SwissProt Accessions	Q16478	Gene names	GRIK5, GRIK2
Domain Architecture
Description	Glutamate receptor, ionotropic kainate 5 precursor (Glutamate receptor KA-2) (KA2) (Excitatory amino acid receptor 2) (EAA2).

GRIK5_MOUSE
θ value	0 (rank : 7)	NC score	0.999842 (rank : 2)
Query Neighborhood Hits	44	Target Neighborhood Hits	47	Shared Neighborhood Hits	43
SwissProt Accessions	Q61626	Gene names	Grik5
Domain Architecture
Description	Glutamate receptor, ionotropic kainate 5 precursor (Glutamate receptor KA-2) (KA2) (Glutamate receptor gamma-2) (GluR gamma-2).

GRIA3_HUMAN
θ value	2.19465e-147 (rank : 8)	NC score	0.975649 (rank : 11)
Query Neighborhood Hits	44	Target Neighborhood Hits	40	Shared Neighborhood Hits	33
SwissProt Accessions	P42263, Q4VXD5, Q4VXD6, Q9HDA0, Q9HDA1, Q9HDA2	Gene names	GRIA3, GLUR3, GLURC
Domain Architecture
Description	Glutamate receptor 3 precursor (GluR-3) (GluR-C) (GluR-K3) (Glutamate receptor ionotropic, AMPA 3) (AMPA-selective glutamate receptor 3).

GRIA1_HUMAN
θ value	1.42253e-146 (rank : 9)	NC score	0.975816 (rank : 10)
Query Neighborhood Hits	44	Target Neighborhood Hits	45	Shared Neighborhood Hits	33
SwissProt Accessions	P42261	Gene names	GRIA1, GLUH1, GLUR1
Domain Architecture
Description	Glutamate receptor 1 precursor (GluR-1) (GluR-A) (GluR-K1) (Glutamate receptor ionotropic, AMPA 1) (AMPA-selective glutamate receptor 1).

GRIA3_MOUSE
θ value	1.85788e-146 (rank : 10)	NC score	0.975372 (rank : 12)
Query Neighborhood Hits	44	Target Neighborhood Hits	39	Shared Neighborhood Hits	33
SwissProt Accessions	Q9Z2W9, Q5DTJ0	Gene names	Gria3, Glur3, Kiaa4184
Domain Architecture	No domain graphic available
Description	Glutamate receptor 3 precursor (GluR-3) (GluR-C) (GluR-K3) (Glutamate receptor ionotropic, AMPA 3) (AMPA-selective glutamate receptor 3).

GRIA1_MOUSE
θ value	2.42647e-146 (rank : 11)	NC score	0.975890 (rank : 9)
Query Neighborhood Hits	44	Target Neighborhood Hits	46	Shared Neighborhood Hits	33
SwissProt Accessions	P23818	Gene names	Gria1, Glur1
Domain Architecture
Description	Glutamate receptor 1 precursor (GluR-1) (GluR-A) (GluR-K1) (Glutamate receptor ionotropic, AMPA 1) (AMPA-selective glutamate receptor 1).

GRIK1_MOUSE
θ value	9.22056e-146 (rank : 12)	NC score	0.982123 (rank : 8)
Query Neighborhood Hits	44	Target Neighborhood Hits	46	Shared Neighborhood Hits	33
SwissProt Accessions	Q60934	Gene names	Grik1, Glur5
Domain Architecture
Description	Glutamate receptor, ionotropic kainate 1 precursor (Glutamate receptor 5) (GluR-5) (GluR5).

GRIA2_HUMAN
θ value	8.0776e-142 (rank : 13)	NC score	0.974221 (rank : 13)
Query Neighborhood Hits	44	Target Neighborhood Hits	47	Shared Neighborhood Hits	33
SwissProt Accessions	P42262, Q96FP6	Gene names	GRIA2, GLUR2
Domain Architecture
Description	Glutamate receptor 2 precursor (GluR-2) (GluR-B) (GluR-K2) (Glutamate receptor ionotropic, AMPA 2) (AMPA-selective glutamate receptor 2).

GRIA2_MOUSE
θ value	1.37783e-141 (rank : 14)	NC score	0.974078 (rank : 14)
Query Neighborhood Hits	44	Target Neighborhood Hits	47	Shared Neighborhood Hits	33
SwissProt Accessions	P23819, Q61604, Q61605, Q8BG69, Q8BXU3, Q9D6D3	Gene names	Gria2, Glur2
Domain Architecture
Description	Glutamate receptor 2 precursor (GluR-2) (GluR-B) (GluR-K2) (Glutamate receptor ionotropic, AMPA 2) (AMPA-selective glutamate receptor 2).

GRIA4_HUMAN
θ value	5.78879e-140 (rank : 15)	NC score	0.973667 (rank : 15)
Query Neighborhood Hits	44	Target Neighborhood Hits	45	Shared Neighborhood Hits	33
SwissProt Accessions	P48058	Gene names	GRIA4, GLUR4
Domain Architecture
Description	Glutamate receptor 4 precursor (GluR-4) (GluR4) (GluR-D) (Glutamate receptor ionotropic, AMPA 4) (AMPA-selective glutamate receptor 4).

GRIA4_MOUSE
θ value	9.87422e-140 (rank : 16)	NC score	0.973470 (rank : 16)
Query Neighborhood Hits	44	Target Neighborhood Hits	44	Shared Neighborhood Hits	33
SwissProt Accessions	Q9Z2W8	Gene names	Gria4, Glur4
Domain Architecture
Description	Glutamate receptor 4 precursor (GluR-4) (GluR4) (GluR-D) (Glutamate receptor ionotropic, AMPA 4) (AMPA-selective glutamate receptor 4).

GRID2_HUMAN
θ value	6.08852e-81 (rank : 17)	NC score	0.946192 (rank : 17)
Query Neighborhood Hits	44	Target Neighborhood Hits	48	Shared Neighborhood Hits	34
SwissProt Accessions	O43424	Gene names	GRID2, GLURD2
Domain Architecture
Description	Glutamate receptor delta-2 subunit precursor (GluR delta-2).

GRID2_MOUSE
θ value	1.03855e-80 (rank : 18)	NC score	0.946139 (rank : 18)
Query Neighborhood Hits	44	Target Neighborhood Hits	44	Shared Neighborhood Hits	33
SwissProt Accessions	Q61625	Gene names	Grid2
Domain Architecture
Description	Glutamate receptor delta-2 subunit precursor (GluR delta-2).

GRID1_HUMAN
θ value	5.15425e-80 (rank : 19)	NC score	0.945949 (rank : 19)
Query Neighborhood Hits	44	Target Neighborhood Hits	42	Shared Neighborhood Hits	33
SwissProt Accessions	Q9ULK0, Q8IXT3	Gene names	GRID1, KIAA1220
Domain Architecture
Description	Glutamate receptor delta-1 subunit precursor (GluR delta-1).

GRID1_MOUSE
θ value	1.49966e-79 (rank : 20)	NC score	0.945811 (rank : 20)
Query Neighborhood Hits	44	Target Neighborhood Hits	42	Shared Neighborhood Hits	33
SwissProt Accessions	Q61627	Gene names	Grid1
Domain Architecture
Description	Glutamate receptor delta-1 subunit precursor (GluR delta-1).

NMDZ1_MOUSE
θ value	4.52582e-68 (rank : 21)	NC score	0.909782 (rank : 21)
Query Neighborhood Hits	44	Target Neighborhood Hits	76	Shared Neighborhood Hits	33
SwissProt Accessions	P35438, Q8CFS4	Gene names	Grin1, Glurz1
Domain Architecture
Description	Glutamate [NMDA] receptor subunit zeta 1 precursor (N-methyl-D- aspartate receptor subunit NR1).

NMDZ1_HUMAN
θ value	5.00389e-67 (rank : 22)	NC score	0.909591 (rank : 22)
Query Neighborhood Hits	44	Target Neighborhood Hits	77	Shared Neighborhood Hits	33
SwissProt Accessions	Q05586, P35437, Q12867, Q12868	Gene names	GRIN1, NMDAR1
Domain Architecture
Description	Glutamate [NMDA] receptor subunit zeta 1 precursor (N-methyl-D- aspartate receptor subunit NR1).

NMDE4_HUMAN
θ value	1.85029e-45 (rank : 23)	NC score	0.845506 (rank : 26)
Query Neighborhood Hits	44	Target Neighborhood Hits	133	Shared Neighborhood Hits	34
SwissProt Accessions	O15399	Gene names	GRIN2D
Domain Architecture
Description	Glutamate [NMDA] receptor subunit epsilon 4 precursor (N-methyl D- aspartate receptor subtype 2D) (NR2D) (NMDAR2D) (EB11).

NMDE4_MOUSE
θ value	2.41655e-45 (rank : 24)	NC score	0.843202 (rank : 27)
Query Neighborhood Hits	44	Target Neighborhood Hits	158	Shared Neighborhood Hits	34
SwissProt Accessions	Q03391	Gene names	Grin2d
Domain Architecture
Description	Glutamate [NMDA] receptor subunit epsilon 4 precursor (N-methyl D- aspartate receptor subtype 2D) (NR2D) (NMDAR2D).

NMDE1_HUMAN
θ value	3.15612e-45 (rank : 25)	NC score	0.836079 (rank : 33)
Query Neighborhood Hits	44	Target Neighborhood Hits	81	Shared Neighborhood Hits	33
SwissProt Accessions	Q12879, O00669	Gene names	GRIN2A
Domain Architecture
Description	Glutamate [NMDA] receptor subunit epsilon 1 precursor (N-methyl D- aspartate receptor subtype 2A) (NR2A) (NMDAR2A) (hNR2A).

NMDE1_MOUSE
θ value	7.03111e-45 (rank : 26)	NC score	0.836080 (rank : 32)
Query Neighborhood Hits	44	Target Neighborhood Hits	84	Shared Neighborhood Hits	33
SwissProt Accessions	P35436	Gene names	Grin2a
Domain Architecture	No domain graphic available
Description	Glutamate [NMDA] receptor subunit epsilon 1 precursor (N-methyl D- aspartate receptor subtype 2A) (NR2A) (NMDAR2A).

NMDE3_MOUSE
θ value	6.15952e-41 (rank : 27)	NC score	0.840139 (rank : 28)
Query Neighborhood Hits	44	Target Neighborhood Hits	86	Shared Neighborhood Hits	34
SwissProt Accessions	Q01098	Gene names	Grin2c
Domain Architecture
Description	Glutamate [NMDA] receptor subunit epsilon 3 precursor (N-methyl D- aspartate receptor subtype 2C) (NR2C) (NMDAR2C).

NMDE2_HUMAN
θ value	1.05066e-40 (rank : 28)	NC score	0.837246 (rank : 30)
Query Neighborhood Hits	44	Target Neighborhood Hits	65	Shared Neighborhood Hits	33
SwissProt Accessions	Q13224, Q12919, Q13220, Q13225, Q9UM56	Gene names	GRIN2B
Domain Architecture
Description	Glutamate [NMDA] receptor subunit epsilon 2 precursor (N-methyl D- aspartate receptor subtype 2B) (NR2B) (NMDAR2B) (N-methyl-D-aspartate receptor subunit 3) (NR3) (hNR3).

NMDE2_MOUSE
θ value	1.05066e-40 (rank : 29)	NC score	0.837232 (rank : 31)
Query Neighborhood Hits	44	Target Neighborhood Hits	64	Shared Neighborhood Hits	33
SwissProt Accessions	Q01097, Q9DCB2	Gene names	Grin2b
Domain Architecture
Description	Glutamate [NMDA] receptor subunit epsilon 2 precursor (N-methyl D- aspartate receptor subtype 2B) (NR2B) (NMDAR2B).

NMDE3_HUMAN
θ value	3.05695e-40 (rank : 30)	NC score	0.838540 (rank : 29)
Query Neighborhood Hits	44	Target Neighborhood Hits	110	Shared Neighborhood Hits	33
SwissProt Accessions	Q14957	Gene names	GRIN2C
Domain Architecture
Description	Glutamate [NMDA] receptor subunit epsilon 3 precursor (N-methyl D- aspartate receptor subtype 2C) (NR2C) (NMDAR2C).

NMD3B_MOUSE
θ value	2.26708e-35 (rank : 31)	NC score	0.861999 (rank : 25)
Query Neighborhood Hits	44	Target Neighborhood Hits	51	Shared Neighborhood Hits	33
SwissProt Accessions	Q91ZU9, Q8VHV0	Gene names	Grin3b
Domain Architecture	No domain graphic available
Description	Glutamate [NMDA] receptor subunit 3B precursor (N-methyl-D-aspartate receptor subunit NR3B) (NR3B) (NMDAR3B) (NMDA receptor NR4) (Nr4).

NMD3B_HUMAN
θ value	2.96089e-35 (rank : 32)	NC score	0.863599 (rank : 24)
Query Neighborhood Hits	44	Target Neighborhood Hits	55	Shared Neighborhood Hits	33
SwissProt Accessions	O60391, Q5EAK7, Q7RTW9	Gene names	GRIN3B
Domain Architecture	No domain graphic available
Description	Glutamate [NMDA] receptor subunit 3B precursor (N-methyl-D-aspartate receptor subtype NR3B) (NR3B) (NMDAR3B).

NMD3A_HUMAN
θ value	6.59618e-35 (rank : 33)	NC score	0.866161 (rank : 23)
Query Neighborhood Hits	44	Target Neighborhood Hits	58	Shared Neighborhood Hits	34
SwissProt Accessions	Q8TCU5, Q8TF29, Q8WXI6	Gene names	GRIN3A, KIAA1973
Domain Architecture	No domain graphic available
Description	Glutamate [NMDA] receptor subunit 3A precursor (N-methyl-D-aspartate receptor subtype NR3A) (NMDAR-L).

PSL1_HUMAN
θ value	0.813845 (rank : 34)	NC score	0.021760 (rank : 37)
Query Neighborhood Hits	44	Target Neighborhood Hits	650	Shared Neighborhood Hits	8
SwissProt Accessions	Q8TCT7, O60365, Q567S3, Q8IUH9, Q9BUY6, Q9H3M4, Q9NPN2, Q9P1Z6	Gene names	SPPL2B, KIAA1532, PSL1
Domain Architecture
Description	Signal peptide peptidase-like 2B (EC 3.4.23.-) (Protein SPP-like 2B) (Protein SPPL2b) (Intramembrane protease 4) (IMP4) (Presenilin-like protein 1).

MAP4_MOUSE
θ value	1.06291 (rank : 35)	NC score	0.015715 (rank : 38)
Query Neighborhood Hits	44	Target Neighborhood Hits	409	Shared Neighborhood Hits	4
SwissProt Accessions	P27546	Gene names	Map4, Mtap4
Domain Architecture
Description	Microtubule-associated protein 4 (MAP 4).

CHST8_MOUSE
θ value	3.0926 (rank : 36)	NC score	0.008373 (rank : 45)
Query Neighborhood Hits	44	Target Neighborhood Hits	29	Shared Neighborhood Hits	3
SwissProt Accessions	Q8BQ86, Q76EC6, Q80XD4	Gene names	Chst8
Domain Architecture	No domain graphic available
Description	Carbohydrate sulfotransferase 8 (EC 2.8.2.-) (N-acetylgalactosamine-4- O-sulfotransferase 1) (GalNAc-4-O-sulfotransferase 1) (GalNAc-4-ST1) (GalNAc4ST-1).

GPR56_MOUSE
θ value	4.03905 (rank : 37)	NC score	0.005610 (rank : 46)
Query Neighborhood Hits	44	Target Neighborhood Hits	89	Shared Neighborhood Hits	3
SwissProt Accessions	Q8K209, Q3UR17, Q9QZT2	Gene names	Gpr56, Cyt28
Domain Architecture
Description	G-protein coupled receptor 56 precursor (Serpentine receptor cyt28).

S39A1_MOUSE
θ value	4.03905 (rank : 38)	NC score	0.009596 (rank : 44)
Query Neighborhood Hits	44	Target Neighborhood Hits	15	Shared Neighborhood Hits	2
SwissProt Accessions	Q9QZ03, Q99K44	Gene names	Slc39a1, Zip1, Zirtl
Domain Architecture
Description	Zinc transporter ZIP1 (Zinc-iron-regulated transporter-like) (Solute carrier family 39 member 1).

AP2A2_HUMAN
θ value	5.27518 (rank : 39)	NC score	0.010397 (rank : 41)
Query Neighborhood Hits	44	Target Neighborhood Hits	39	Shared Neighborhood Hits	6
SwissProt Accessions	O94973, O75403, Q96SI8	Gene names	AP2A2, ADTAB, KIAA0899
Domain Architecture
Description	AP-2 complex subunit alpha-2 (Adapter-related protein complex 2 alpha- 2 subunit) (Alpha-adaptin C) (Adaptor protein complex AP-2 alpha-2 subunit) (Clathrin assembly protein complex 2 alpha-C large chain) (100 kDa coated vesicle protein C) (Plasma membrane adaptor HA2/AP2 adaptin alpha C subunit) (Huntingtin-interacting protein HYPJ).

AP2A2_MOUSE
θ value	5.27518 (rank : 40)	NC score	0.010369 (rank : 42)
Query Neighborhood Hits	44	Target Neighborhood Hits	46	Shared Neighborhood Hits	6
SwissProt Accessions	P17427, Q921V0	Gene names	Ap2a2, Adtab
Domain Architecture
Description	AP-2 complex subunit alpha-2 (Adapter-related protein complex 2 alpha- 2 subunit) (Alpha-adaptin C) (Adaptor protein complex AP-2 alpha-2 subunit) (Clathrin assembly protein complex 2 alpha-C large chain) (100 kDa coated vesicle protein C) (Plasma membrane adaptor HA2/AP2 adaptin alpha C subunit).

FGD1_HUMAN
θ value	5.27518 (rank : 41)	NC score	0.003088 (rank : 47)
Query Neighborhood Hits	44	Target Neighborhood Hits	367	Shared Neighborhood Hits	4
SwissProt Accessions	P98174, Q8N4D9	Gene names	FGD1, ZFYVE3
Domain Architecture
Description	FYVE, RhoGEF and PH domain-containing protein 1 (Faciogenital dysplasia 1 protein) (Zinc finger FYVE domain-containing protein 3) (Rho/Rac guanine nucleotide exchange factor FGD1) (Rho/Rac GEF).

MLH1_HUMAN
θ value	5.27518 (rank : 42)	NC score	0.009691 (rank : 43)
Query Neighborhood Hits	44	Target Neighborhood Hits	30	Shared Neighborhood Hits	3
SwissProt Accessions	P40692	Gene names	MLH1, COCA2
Domain Architecture
Description	DNA mismatch repair protein Mlh1 (MutL protein homolog 1).

AP2A1_HUMAN
θ value	8.99809 (rank : 43)	NC score	0.011266 (rank : 40)
Query Neighborhood Hits	44	Target Neighborhood Hits	56	Shared Neighborhood Hits	6
SwissProt Accessions	O95782, Q96CI7, Q96PP6, Q96PP7, Q9H070	Gene names	AP2A1, ADTAA
Domain Architecture
Description	AP-2 complex subunit alpha-1 (Adapter-related protein complex 2 alpha- 1 subunit) (Alpha-adaptin A) (Adaptor protein complex AP-2 alpha-1 subunit) (Clathrin assembly protein complex 2 alpha-A large chain) (100 kDa coated vesicle protein A) (Plasma membrane adaptor HA2/AP2 adaptin alpha A subunit).

AP2A1_MOUSE
θ value	8.99809 (rank : 44)	NC score	0.011305 (rank : 39)
Query Neighborhood Hits	44	Target Neighborhood Hits	57	Shared Neighborhood Hits	6
SwissProt Accessions	P17426	Gene names	Ap2a1, Adtaa, Clapa1
Domain Architecture
Description	AP-2 complex subunit alpha-1 (Adapter-related protein complex 2 alpha- 1 subunit) (Alpha-adaptin A) (Adaptor protein complex AP-2 alpha-1 subunit) (Clathrin assembly protein complex 2 alpha-A large chain) (100 kDa coated vesicle protein A) (Plasma membrane adaptor HA2/AP2 adaptin alpha A subunit).

ERB1_HUMAN
θ value	θ > 10 (rank : 45)	NC score	0.054422 (rank : 36)
Query Neighborhood Hits	44	Target Neighborhood Hits	23	Shared Neighborhood Hits	8
SwissProt Accessions	P60509	Gene names
Domain Architecture	No domain graphic available
Description	HERV-R(b)_3p24.3 provirus ancestral Env polyprotein precursor (Envelope polyprotein) (HERV-R(b) Env protein) [Includes: Surface protein domain (SU); Transmembrane protein domain (TM)].

GABR1_HUMAN
θ value	θ > 10 (rank : 46)	NC score	0.057909 (rank : 34)
Query Neighborhood Hits	44	Target Neighborhood Hits	142	Shared Neighborhood Hits	13
SwissProt Accessions	Q9UBS5, O95375, O95468, O95975, O96022, Q86W60, Q9UQQ0	Gene names	GABBR1, GPRC3A
Domain Architecture
Description	Gamma-aminobutyric acid type B receptor, subunit 1 precursor (GABA-B receptor 1) (GABA-B-R1) (Gb1).

GABR1_MOUSE
θ value	θ > 10 (rank : 47)	NC score	0.057763 (rank : 35)
Query Neighborhood Hits	44	Target Neighborhood Hits	139	Shared Neighborhood Hits	13
SwissProt Accessions	Q9WV18, Q9WU48, Q9WV15, Q9WV16, Q9WV17	Gene names	Gabbr1
Domain Architecture
Description	Gamma-aminobutyric acid type B receptor, subunit 1 precursor (GABA-B receptor 1) (GABA-B-R1) (Gb1).

Hits sorted by NC score

GRIK5_HUMAN
NC score	0.999962 (rank : 1)	θ value	0 (rank : 6)
Query Neighborhood Hits	44	Target Neighborhood Hits	44	Shared Neighborhood Hits	44
SwissProt Accessions	Q16478	Gene names	GRIK5, GRIK2
Domain Architecture
Description	Glutamate receptor, ionotropic kainate 5 precursor (Glutamate receptor KA-2) (KA2) (Excitatory amino acid receptor 2) (EAA2).

GRIK5_MOUSE
NC score	0.999842 (rank : 2)	θ value	0 (rank : 7)
Query Neighborhood Hits	44	Target Neighborhood Hits	47	Shared Neighborhood Hits	43
SwissProt Accessions	Q61626	Gene names	Grik5
Domain Architecture
Description	Glutamate receptor, ionotropic kainate 5 precursor (Glutamate receptor KA-2) (KA2) (Glutamate receptor gamma-2) (GluR gamma-2).

GRIK4_MOUSE
NC score	0.998372 (rank : 3)	θ value	0 (rank : 5)
Query Neighborhood Hits	44	Target Neighborhood Hits	41	Shared Neighborhood Hits	33
SwissProt Accessions	Q8BMF5	Gene names	Grik4
Domain Architecture	No domain graphic available
Description	Glutamate receptor, ionotropic kainate 4 precursor.

GRIK4_HUMAN
NC score	0.998309 (rank : 4)	θ value	0 (rank : 4)
Query Neighborhood Hits	44	Target Neighborhood Hits	42	Shared Neighborhood Hits	33
SwissProt Accessions	Q16099	Gene names	GRIK4, GRIK
Domain Architecture
Description	Glutamate receptor, ionotropic kainate 4 precursor (Glutamate receptor KA-1) (KA1) (Excitatory amino acid receptor 1) (EAA1).

GRIK3_HUMAN
NC score	0.988528 (rank : 5)	θ value	0 (rank : 3)
Query Neighborhood Hits	44	Target Neighborhood Hits	41	Shared Neighborhood Hits	33
SwissProt Accessions	Q13003, Q13004, Q16136	Gene names	GRIK3, GLUR7
Domain Architecture
Description	Glutamate receptor, ionotropic kainate 3 precursor (Glutamate receptor 7) (GluR-7) (GluR7) (Excitatory amino acid receptor 5) (EAA5).

GRIK2_HUMAN
NC score	0.987016 (rank : 6)	θ value	0 (rank : 2)
Query Neighborhood Hits	44	Target Neighborhood Hits	50	Shared Neighborhood Hits	33
SwissProt Accessions	Q13002	Gene names	GRIK2, GLUR6
Domain Architecture
Description	Glutamate receptor, ionotropic kainate 2 precursor (Glutamate receptor 6) (GluR-6) (GluR6) (Excitatory amino acid receptor 4) (EAA4).

GRIK1_HUMAN
NC score	0.985776 (rank : 7)	θ value	0 (rank : 1)
Query Neighborhood Hits	44	Target Neighborhood Hits	48	Shared Neighborhood Hits	33
SwissProt Accessions	P39086, Q13001, Q86SU9	Gene names	GRIK1, GLUR5
Domain Architecture
Description	Glutamate receptor, ionotropic kainate 1 precursor (Glutamate receptor 5) (GluR-5) (GluR5) (Excitatory amino acid receptor 3) (EAA3).

GRIK1_MOUSE
NC score	0.982123 (rank : 8)	θ value	9.22056e-146 (rank : 12)
Query Neighborhood Hits	44	Target Neighborhood Hits	46	Shared Neighborhood Hits	33
SwissProt Accessions	Q60934	Gene names	Grik1, Glur5
Domain Architecture
Description	Glutamate receptor, ionotropic kainate 1 precursor (Glutamate receptor 5) (GluR-5) (GluR5).

GRIA1_MOUSE
NC score	0.975890 (rank : 9)	θ value	2.42647e-146 (rank : 11)
Query Neighborhood Hits	44	Target Neighborhood Hits	46	Shared Neighborhood Hits	33
SwissProt Accessions	P23818	Gene names	Gria1, Glur1
Domain Architecture
Description	Glutamate receptor 1 precursor (GluR-1) (GluR-A) (GluR-K1) (Glutamate receptor ionotropic, AMPA 1) (AMPA-selective glutamate receptor 1).

GRIA1_HUMAN
NC score	0.975816 (rank : 10)	θ value	1.42253e-146 (rank : 9)
Query Neighborhood Hits	44	Target Neighborhood Hits	45	Shared Neighborhood Hits	33
SwissProt Accessions	P42261	Gene names	GRIA1, GLUH1, GLUR1
Domain Architecture
Description	Glutamate receptor 1 precursor (GluR-1) (GluR-A) (GluR-K1) (Glutamate receptor ionotropic, AMPA 1) (AMPA-selective glutamate receptor 1).

GRIA3_HUMAN
NC score	0.975649 (rank : 11)	θ value	2.19465e-147 (rank : 8)
Query Neighborhood Hits	44	Target Neighborhood Hits	40	Shared Neighborhood Hits	33
SwissProt Accessions	P42263, Q4VXD5, Q4VXD6, Q9HDA0, Q9HDA1, Q9HDA2	Gene names	GRIA3, GLUR3, GLURC
Domain Architecture
Description	Glutamate receptor 3 precursor (GluR-3) (GluR-C) (GluR-K3) (Glutamate receptor ionotropic, AMPA 3) (AMPA-selective glutamate receptor 3).

GRIA3_MOUSE
NC score	0.975372 (rank : 12)	θ value	1.85788e-146 (rank : 10)
Query Neighborhood Hits	44	Target Neighborhood Hits	39	Shared Neighborhood Hits	33
SwissProt Accessions	Q9Z2W9, Q5DTJ0	Gene names	Gria3, Glur3, Kiaa4184
Domain Architecture	No domain graphic available
Description	Glutamate receptor 3 precursor (GluR-3) (GluR-C) (GluR-K3) (Glutamate receptor ionotropic, AMPA 3) (AMPA-selective glutamate receptor 3).

GRIA2_HUMAN
NC score	0.974221 (rank : 13)	θ value	8.0776e-142 (rank : 13)
Query Neighborhood Hits	44	Target Neighborhood Hits	47	Shared Neighborhood Hits	33
SwissProt Accessions	P42262, Q96FP6	Gene names	GRIA2, GLUR2
Domain Architecture
Description	Glutamate receptor 2 precursor (GluR-2) (GluR-B) (GluR-K2) (Glutamate receptor ionotropic, AMPA 2) (AMPA-selective glutamate receptor 2).

GRIA2_MOUSE
NC score	0.974078 (rank : 14)	θ value	1.37783e-141 (rank : 14)
Query Neighborhood Hits	44	Target Neighborhood Hits	47	Shared Neighborhood Hits	33
SwissProt Accessions	P23819, Q61604, Q61605, Q8BG69, Q8BXU3, Q9D6D3	Gene names	Gria2, Glur2
Domain Architecture
Description	Glutamate receptor 2 precursor (GluR-2) (GluR-B) (GluR-K2) (Glutamate receptor ionotropic, AMPA 2) (AMPA-selective glutamate receptor 2).

GRIA4_HUMAN
NC score	0.973667 (rank : 15)	θ value	5.78879e-140 (rank : 15)
Query Neighborhood Hits	44	Target Neighborhood Hits	45	Shared Neighborhood Hits	33
SwissProt Accessions	P48058	Gene names	GRIA4, GLUR4
Domain Architecture
Description	Glutamate receptor 4 precursor (GluR-4) (GluR4) (GluR-D) (Glutamate receptor ionotropic, AMPA 4) (AMPA-selective glutamate receptor 4).

GRIA4_MOUSE
NC score	0.973470 (rank : 16)	θ value	9.87422e-140 (rank : 16)
Query Neighborhood Hits	44	Target Neighborhood Hits	44	Shared Neighborhood Hits	33
SwissProt Accessions	Q9Z2W8	Gene names	Gria4, Glur4
Domain Architecture
Description	Glutamate receptor 4 precursor (GluR-4) (GluR4) (GluR-D) (Glutamate receptor ionotropic, AMPA 4) (AMPA-selective glutamate receptor 4).

GRID2_HUMAN
NC score	0.946192 (rank : 17)	θ value	6.08852e-81 (rank : 17)
Query Neighborhood Hits	44	Target Neighborhood Hits	48	Shared Neighborhood Hits	34
SwissProt Accessions	O43424	Gene names	GRID2, GLURD2
Domain Architecture
Description	Glutamate receptor delta-2 subunit precursor (GluR delta-2).

GRID2_MOUSE
NC score	0.946139 (rank : 18)	θ value	1.03855e-80 (rank : 18)
Query Neighborhood Hits	44	Target Neighborhood Hits	44	Shared Neighborhood Hits	33
SwissProt Accessions	Q61625	Gene names	Grid2
Domain Architecture
Description	Glutamate receptor delta-2 subunit precursor (GluR delta-2).

GRID1_HUMAN
NC score	0.945949 (rank : 19)	θ value	5.15425e-80 (rank : 19)
Query Neighborhood Hits	44	Target Neighborhood Hits	42	Shared Neighborhood Hits	33
SwissProt Accessions	Q9ULK0, Q8IXT3	Gene names	GRID1, KIAA1220
Domain Architecture
Description	Glutamate receptor delta-1 subunit precursor (GluR delta-1).

GRID1_MOUSE
NC score	0.945811 (rank : 20)	θ value	1.49966e-79 (rank : 20)
Query Neighborhood Hits	44	Target Neighborhood Hits	42	Shared Neighborhood Hits	33
SwissProt Accessions	Q61627	Gene names	Grid1
Domain Architecture
Description	Glutamate receptor delta-1 subunit precursor (GluR delta-1).

NMDZ1_MOUSE
NC score	0.909782 (rank : 21)	θ value	4.52582e-68 (rank : 21)
Query Neighborhood Hits	44	Target Neighborhood Hits	76	Shared Neighborhood Hits	33
SwissProt Accessions	P35438, Q8CFS4	Gene names	Grin1, Glurz1
Domain Architecture
Description	Glutamate [NMDA] receptor subunit zeta 1 precursor (N-methyl-D- aspartate receptor subunit NR1).

NMDZ1_HUMAN
NC score	0.909591 (rank : 22)	θ value	5.00389e-67 (rank : 22)
Query Neighborhood Hits	44	Target Neighborhood Hits	77	Shared Neighborhood Hits	33
SwissProt Accessions	Q05586, P35437, Q12867, Q12868	Gene names	GRIN1, NMDAR1
Domain Architecture
Description	Glutamate [NMDA] receptor subunit zeta 1 precursor (N-methyl-D- aspartate receptor subunit NR1).

NMD3A_HUMAN
NC score	0.866161 (rank : 23)	θ value	6.59618e-35 (rank : 33)
Query Neighborhood Hits	44	Target Neighborhood Hits	58	Shared Neighborhood Hits	34
SwissProt Accessions	Q8TCU5, Q8TF29, Q8WXI6	Gene names	GRIN3A, KIAA1973
Domain Architecture	No domain graphic available
Description	Glutamate [NMDA] receptor subunit 3A precursor (N-methyl-D-aspartate receptor subtype NR3A) (NMDAR-L).

NMD3B_HUMAN
NC score	0.863599 (rank : 24)	θ value	2.96089e-35 (rank : 32)
Query Neighborhood Hits	44	Target Neighborhood Hits	55	Shared Neighborhood Hits	33
SwissProt Accessions	O60391, Q5EAK7, Q7RTW9	Gene names	GRIN3B
Domain Architecture	No domain graphic available
Description	Glutamate [NMDA] receptor subunit 3B precursor (N-methyl-D-aspartate receptor subtype NR3B) (NR3B) (NMDAR3B).

NMD3B_MOUSE
NC score	0.861999 (rank : 25)	θ value	2.26708e-35 (rank : 31)
Query Neighborhood Hits	44	Target Neighborhood Hits	51	Shared Neighborhood Hits	33
SwissProt Accessions	Q91ZU9, Q8VHV0	Gene names	Grin3b
Domain Architecture	No domain graphic available
Description	Glutamate [NMDA] receptor subunit 3B precursor (N-methyl-D-aspartate receptor subunit NR3B) (NR3B) (NMDAR3B) (NMDA receptor NR4) (Nr4).

NMDE4_HUMAN
NC score	0.845506 (rank : 26)	θ value	1.85029e-45 (rank : 23)
Query Neighborhood Hits	44	Target Neighborhood Hits	133	Shared Neighborhood Hits	34
SwissProt Accessions	O15399	Gene names	GRIN2D
Domain Architecture
Description	Glutamate [NMDA] receptor subunit epsilon 4 precursor (N-methyl D- aspartate receptor subtype 2D) (NR2D) (NMDAR2D) (EB11).

NMDE4_MOUSE
NC score	0.843202 (rank : 27)	θ value	2.41655e-45 (rank : 24)
Query Neighborhood Hits	44	Target Neighborhood Hits	158	Shared Neighborhood Hits	34
SwissProt Accessions	Q03391	Gene names	Grin2d
Domain Architecture
Description	Glutamate [NMDA] receptor subunit epsilon 4 precursor (N-methyl D- aspartate receptor subtype 2D) (NR2D) (NMDAR2D).

NMDE3_MOUSE
NC score	0.840139 (rank : 28)	θ value	6.15952e-41 (rank : 27)
Query Neighborhood Hits	44	Target Neighborhood Hits	86	Shared Neighborhood Hits	34
SwissProt Accessions	Q01098	Gene names	Grin2c
Domain Architecture
Description	Glutamate [NMDA] receptor subunit epsilon 3 precursor (N-methyl D- aspartate receptor subtype 2C) (NR2C) (NMDAR2C).

NMDE3_HUMAN
NC score	0.838540 (rank : 29)	θ value	3.05695e-40 (rank : 30)
Query Neighborhood Hits	44	Target Neighborhood Hits	110	Shared Neighborhood Hits	33
SwissProt Accessions	Q14957	Gene names	GRIN2C
Domain Architecture
Description	Glutamate [NMDA] receptor subunit epsilon 3 precursor (N-methyl D- aspartate receptor subtype 2C) (NR2C) (NMDAR2C).

NMDE2_HUMAN
NC score	0.837246 (rank : 30)	θ value	1.05066e-40 (rank : 28)
Query Neighborhood Hits	44	Target Neighborhood Hits	65	Shared Neighborhood Hits	33
SwissProt Accessions	Q13224, Q12919, Q13220, Q13225, Q9UM56	Gene names	GRIN2B
Domain Architecture
Description	Glutamate [NMDA] receptor subunit epsilon 2 precursor (N-methyl D- aspartate receptor subtype 2B) (NR2B) (NMDAR2B) (N-methyl-D-aspartate receptor subunit 3) (NR3) (hNR3).

NMDE2_MOUSE
NC score	0.837232 (rank : 31)	θ value	1.05066e-40 (rank : 29)
Query Neighborhood Hits	44	Target Neighborhood Hits	64	Shared Neighborhood Hits	33
SwissProt Accessions	Q01097, Q9DCB2	Gene names	Grin2b
Domain Architecture
Description	Glutamate [NMDA] receptor subunit epsilon 2 precursor (N-methyl D- aspartate receptor subtype 2B) (NR2B) (NMDAR2B).

NMDE1_MOUSE
NC score	0.836080 (rank : 32)	θ value	7.03111e-45 (rank : 26)
Query Neighborhood Hits	44	Target Neighborhood Hits	84	Shared Neighborhood Hits	33
SwissProt Accessions	P35436	Gene names	Grin2a
Domain Architecture	No domain graphic available
Description	Glutamate [NMDA] receptor subunit epsilon 1 precursor (N-methyl D- aspartate receptor subtype 2A) (NR2A) (NMDAR2A).

NMDE1_HUMAN
NC score	0.836079 (rank : 33)	θ value	3.15612e-45 (rank : 25)
Query Neighborhood Hits	44	Target Neighborhood Hits	81	Shared Neighborhood Hits	33
SwissProt Accessions	Q12879, O00669	Gene names	GRIN2A
Domain Architecture
Description	Glutamate [NMDA] receptor subunit epsilon 1 precursor (N-methyl D- aspartate receptor subtype 2A) (NR2A) (NMDAR2A) (hNR2A).

GABR1_HUMAN
NC score	0.057909 (rank : 34)	θ value	θ > 10 (rank : 46)
Query Neighborhood Hits	44	Target Neighborhood Hits	142	Shared Neighborhood Hits	13
SwissProt Accessions	Q9UBS5, O95375, O95468, O95975, O96022, Q86W60, Q9UQQ0	Gene names	GABBR1, GPRC3A
Domain Architecture
Description	Gamma-aminobutyric acid type B receptor, subunit 1 precursor (GABA-B receptor 1) (GABA-B-R1) (Gb1).

GABR1_MOUSE
NC score	0.057763 (rank : 35)	θ value	θ > 10 (rank : 47)
Query Neighborhood Hits	44	Target Neighborhood Hits	139	Shared Neighborhood Hits	13
SwissProt Accessions	Q9WV18, Q9WU48, Q9WV15, Q9WV16, Q9WV17	Gene names	Gabbr1
Domain Architecture
Description	Gamma-aminobutyric acid type B receptor, subunit 1 precursor (GABA-B receptor 1) (GABA-B-R1) (Gb1).

ERB1_HUMAN
NC score	0.054422 (rank : 36)	θ value	θ > 10 (rank : 45)
Query Neighborhood Hits	44	Target Neighborhood Hits	23	Shared Neighborhood Hits	8
SwissProt Accessions	P60509	Gene names
Domain Architecture	No domain graphic available
Description	HERV-R(b)_3p24.3 provirus ancestral Env polyprotein precursor (Envelope polyprotein) (HERV-R(b) Env protein) [Includes: Surface protein domain (SU); Transmembrane protein domain (TM)].

PSL1_HUMAN
NC score	0.021760 (rank : 37)	θ value	0.813845 (rank : 34)
Query Neighborhood Hits	44	Target Neighborhood Hits	650	Shared Neighborhood Hits	8
SwissProt Accessions	Q8TCT7, O60365, Q567S3, Q8IUH9, Q9BUY6, Q9H3M4, Q9NPN2, Q9P1Z6	Gene names	SPPL2B, KIAA1532, PSL1
Domain Architecture
Description	Signal peptide peptidase-like 2B (EC 3.4.23.-) (Protein SPP-like 2B) (Protein SPPL2b) (Intramembrane protease 4) (IMP4) (Presenilin-like protein 1).

MAP4_MOUSE
NC score	0.015715 (rank : 38)	θ value	1.06291 (rank : 35)
Query Neighborhood Hits	44	Target Neighborhood Hits	409	Shared Neighborhood Hits	4
SwissProt Accessions	P27546	Gene names	Map4, Mtap4
Domain Architecture
Description	Microtubule-associated protein 4 (MAP 4).

AP2A1_MOUSE
NC score	0.011305 (rank : 39)	θ value	8.99809 (rank : 44)
Query Neighborhood Hits	44	Target Neighborhood Hits	57	Shared Neighborhood Hits	6
SwissProt Accessions	P17426	Gene names	Ap2a1, Adtaa, Clapa1
Domain Architecture
Description	AP-2 complex subunit alpha-1 (Adapter-related protein complex 2 alpha- 1 subunit) (Alpha-adaptin A) (Adaptor protein complex AP-2 alpha-1 subunit) (Clathrin assembly protein complex 2 alpha-A large chain) (100 kDa coated vesicle protein A) (Plasma membrane adaptor HA2/AP2 adaptin alpha A subunit).

AP2A1_HUMAN
NC score	0.011266 (rank : 40)	θ value	8.99809 (rank : 43)
Query Neighborhood Hits	44	Target Neighborhood Hits	56	Shared Neighborhood Hits	6
SwissProt Accessions	O95782, Q96CI7, Q96PP6, Q96PP7, Q9H070	Gene names	AP2A1, ADTAA
Domain Architecture
Description	AP-2 complex subunit alpha-1 (Adapter-related protein complex 2 alpha- 1 subunit) (Alpha-adaptin A) (Adaptor protein complex AP-2 alpha-1 subunit) (Clathrin assembly protein complex 2 alpha-A large chain) (100 kDa coated vesicle protein A) (Plasma membrane adaptor HA2/AP2 adaptin alpha A subunit).

AP2A2_HUMAN
NC score	0.010397 (rank : 41)	θ value	5.27518 (rank : 39)
Query Neighborhood Hits	44	Target Neighborhood Hits	39	Shared Neighborhood Hits	6
SwissProt Accessions	O94973, O75403, Q96SI8	Gene names	AP2A2, ADTAB, KIAA0899
Domain Architecture
Description	AP-2 complex subunit alpha-2 (Adapter-related protein complex 2 alpha- 2 subunit) (Alpha-adaptin C) (Adaptor protein complex AP-2 alpha-2 subunit) (Clathrin assembly protein complex 2 alpha-C large chain) (100 kDa coated vesicle protein C) (Plasma membrane adaptor HA2/AP2 adaptin alpha C subunit) (Huntingtin-interacting protein HYPJ).

AP2A2_MOUSE
NC score	0.010369 (rank : 42)	θ value	5.27518 (rank : 40)
Query Neighborhood Hits	44	Target Neighborhood Hits	46	Shared Neighborhood Hits	6
SwissProt Accessions	P17427, Q921V0	Gene names	Ap2a2, Adtab
Domain Architecture
Description	AP-2 complex subunit alpha-2 (Adapter-related protein complex 2 alpha- 2 subunit) (Alpha-adaptin C) (Adaptor protein complex AP-2 alpha-2 subunit) (Clathrin assembly protein complex 2 alpha-C large chain) (100 kDa coated vesicle protein C) (Plasma membrane adaptor HA2/AP2 adaptin alpha C subunit).

MLH1_HUMAN
NC score	0.009691 (rank : 43)	θ value	5.27518 (rank : 42)
Query Neighborhood Hits	44	Target Neighborhood Hits	30	Shared Neighborhood Hits	3
SwissProt Accessions	P40692	Gene names	MLH1, COCA2
Domain Architecture
Description	DNA mismatch repair protein Mlh1 (MutL protein homolog 1).

S39A1_MOUSE
NC score	0.009596 (rank : 44)	θ value	4.03905 (rank : 38)
Query Neighborhood Hits	44	Target Neighborhood Hits	15	Shared Neighborhood Hits	2
SwissProt Accessions	Q9QZ03, Q99K44	Gene names	Slc39a1, Zip1, Zirtl
Domain Architecture
Description	Zinc transporter ZIP1 (Zinc-iron-regulated transporter-like) (Solute carrier family 39 member 1).

CHST8_MOUSE
NC score	0.008373 (rank : 45)	θ value	3.0926 (rank : 36)
Query Neighborhood Hits	44	Target Neighborhood Hits	29	Shared Neighborhood Hits	3
SwissProt Accessions	Q8BQ86, Q76EC6, Q80XD4	Gene names	Chst8
Domain Architecture	No domain graphic available
Description	Carbohydrate sulfotransferase 8 (EC 2.8.2.-) (N-acetylgalactosamine-4- O-sulfotransferase 1) (GalNAc-4-O-sulfotransferase 1) (GalNAc-4-ST1) (GalNAc4ST-1).

GPR56_MOUSE
NC score	0.005610 (rank : 46)	θ value	4.03905 (rank : 37)
Query Neighborhood Hits	44	Target Neighborhood Hits	89	Shared Neighborhood Hits	3
SwissProt Accessions	Q8K209, Q3UR17, Q9QZT2	Gene names	Gpr56, Cyt28
Domain Architecture
Description	G-protein coupled receptor 56 precursor (Serpentine receptor cyt28).

FGD1_HUMAN
NC score	0.003088 (rank : 47)	θ value	5.27518 (rank : 41)
Query Neighborhood Hits	44	Target Neighborhood Hits	367	Shared Neighborhood Hits	4
SwissProt Accessions	P98174, Q8N4D9	Gene names	FGD1, ZFYVE3
Domain Architecture
Description	FYVE, RhoGEF and PH domain-containing protein 1 (Faciogenital dysplasia 1 protein) (Zinc finger FYVE domain-containing protein 3) (Rho/Rac guanine nucleotide exchange factor FGD1) (Rho/Rac GEF).