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Network neighborhood for query Sequence : SPHK2_HUMAN

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SPHK2_HUMAN
SwissProt Accessions	Q9NRA0, Q9BRN1, Q9H0Q2, Q9NWU7	Gene names	SPHK2
Domain Architecture
Description	Sphingosine kinase 2 (EC 2.7.1.-) (SK 2) (SPK 2).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

SPHK2_HUMAN
θ value	0 (rank : 1)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	81	Target Neighborhood Hits	81	Shared Neighborhood Hits	81
SwissProt Accessions	Q9NRA0, Q9BRN1, Q9H0Q2, Q9NWU7	Gene names	SPHK2
Domain Architecture
Description	Sphingosine kinase 2 (EC 2.7.1.-) (SK 2) (SPK 2).

SPHK2_MOUSE
θ value	0 (rank : 2)	NC score	0.978938 (rank : 2)
Query Neighborhood Hits	81	Target Neighborhood Hits	78	Shared Neighborhood Hits	25
SwissProt Accessions	Q9JIA7, Q91VA9, Q9DBH6	Gene names	Sphk2
Domain Architecture
Description	Sphingosine kinase 2 (EC 2.7.1.-) (SK 2) (SPK 2).

SPHK1_HUMAN
θ value	3.974e-56 (rank : 3)	NC score	0.903900 (rank : 3)
Query Neighborhood Hits	81	Target Neighborhood Hits	15	Shared Neighborhood Hits	9
SwissProt Accessions	Q9NYA1, Q9HD92, Q9NY70, Q9NYL3	Gene names	SPHK1, SPHK, SPK
Domain Architecture
Description	Sphingosine kinase 1 (EC 2.7.1.-) (SK 1) (SPK 1).

CERK1_HUMAN
θ value	8.36355e-22 (rank : 4)	NC score	0.655657 (rank : 4)
Query Neighborhood Hits	81	Target Neighborhood Hits	10	Shared Neighborhood Hits	8
SwissProt Accessions	Q8TCT0, Q9BYB3, Q9UGE5	Gene names	CERK, KIAA1646
Domain Architecture
Description	Ceramide kinase (EC 2.7.1.138) (Acylsphingosine kinase) (hCERK) (Lipid kinase 4) (LK4).

CERK1_MOUSE
θ value	1.33526e-19 (rank : 5)	NC score	0.641539 (rank : 5)
Query Neighborhood Hits	81	Target Neighborhood Hits	17	Shared Neighborhood Hits	9
SwissProt Accessions	Q8K4Q7	Gene names	Cerk
Domain Architecture
Description	Ceramide kinase (EC 2.7.1.138) (Acylsphingosine kinase) (mCERK).

MULK_HUMAN
θ value	4.59992e-12 (rank : 6)	NC score	0.563451 (rank : 6)
Query Neighborhood Hits	81	Target Neighborhood Hits	13	Shared Neighborhood Hits	9
SwissProt Accessions	Q53H12, Q75KN1, Q96GC3, Q9NP48	Gene names	MULK, AGK
Domain Architecture	No domain graphic available
Description	Multiple substrate lipid kinase, mitochondrial precursor (EC 2.7.1.94) (EC 2.7.1.107) (Multi-substrate lipid kinase) (MuLK) (HsMuLK) (Acylglycerol kinase) (hAGK).

MULK_MOUSE
θ value	1.33837e-11 (rank : 7)	NC score	0.559769 (rank : 7)
Query Neighborhood Hits	81	Target Neighborhood Hits	10	Shared Neighborhood Hits	9
SwissProt Accessions	Q9ESW4, Q9D087	Gene names	Mulk
Domain Architecture	No domain graphic available
Description	Multiple substrate lipid kinase, mitochondrial precursor (EC 2.7.1.94) (EC 2.7.1.107) (Multi-substrate lipid kinase) (MuLK).

CERKL_HUMAN
θ value	4.1701e-05 (rank : 8)	NC score	0.457536 (rank : 8)
Query Neighborhood Hits	81	Target Neighborhood Hits	14	Shared Neighborhood Hits	8
SwissProt Accessions	Q49MI3, Q49MH9, Q49MI0, Q49MI1, Q49MI2, Q5DVJ2, Q5DVJ4, Q5DVJ5, Q6UZF6, Q6ZP59	Gene names	CERKL
Domain Architecture	No domain graphic available
Description	Ceramide kinase-like protein.

PRRT3_HUMAN
θ value	0.00390308 (rank : 9)	NC score	0.081382 (rank : 9)
Query Neighborhood Hits	81	Target Neighborhood Hits	998	Shared Neighborhood Hits	32
SwissProt Accessions	Q5FWE3, Q49AD0, Q6UXY6, Q8NBC9	Gene names	PRRT3, UNQ5823/PRO19642
Domain Architecture	No domain graphic available
Description	Proline-rich transmembrane protein 3.

GNAS1_MOUSE
θ value	0.0563607 (rank : 10)	NC score	0.029804 (rank : 37)
Query Neighborhood Hits	81	Target Neighborhood Hits	651	Shared Neighborhood Hits	25
SwissProt Accessions	Q6R0H7, Q6R0H4, Q6R0H5, Q6R2J5, Q9JJX0, Q9Z1N8	Gene names	Gnas, Gnas1
Domain Architecture	No domain graphic available
Description	Guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas (Adenylate cyclase-stimulating G alpha protein) (Extra large alphas protein) (XLalphas).

DGKI_HUMAN
θ value	0.163984 (rank : 11)	NC score	0.075055 (rank : 10)
Query Neighborhood Hits	81	Target Neighborhood Hits	609	Shared Neighborhood Hits	16
SwissProt Accessions	O75912, Q9NZ49	Gene names	DGKI
Domain Architecture
Description	Diacylglycerol kinase iota (EC 2.7.1.107) (Diglyceride kinase iota) (DGK-iota) (DAG kinase iota).

ERCC1_HUMAN
θ value	0.163984 (rank : 12)	NC score	0.061408 (rank : 11)
Query Neighborhood Hits	81	Target Neighborhood Hits	34	Shared Neighborhood Hits	4
SwissProt Accessions	P07992	Gene names	ERCC1
Domain Architecture
Description	DNA excision repair protein ERCC-1.

SON_HUMAN
θ value	0.279714 (rank : 13)	NC score	0.040433 (rank : 27)
Query Neighborhood Hits	81	Target Neighborhood Hits	1568	Shared Neighborhood Hits	28
SwissProt Accessions	P18583, O14487, O95981, Q14120, Q9H7B1, Q9P070, Q9P072, Q9UKP9, Q9UPY0	Gene names	SON, C21orf50, DBP5, KIAA1019, NREBP
Domain Architecture
Description	SON protein (SON3) (Negative regulatory element-binding protein) (NRE- binding protein) (DBP-5) (Bax antagonist selected in saccharomyces 1) (BASS1).

CSKI1_MOUSE
θ value	0.47712 (rank : 14)	NC score	0.025609 (rank : 44)
Query Neighborhood Hits	81	Target Neighborhood Hits	1031	Shared Neighborhood Hits	31
SwissProt Accessions	Q6P9K8, Q6ZPU2, Q8BWU2, Q8BX99, Q9CXH0	Gene names	Caskin1, Kiaa1306
Domain Architecture	No domain graphic available
Description	Caskin-1 (CASK-interacting protein 1).

DMRTD_HUMAN
θ value	0.47712 (rank : 15)	NC score	0.051503 (rank : 17)
Query Neighborhood Hits	81	Target Neighborhood Hits	216	Shared Neighborhood Hits	13
SwissProt Accessions	Q8IXT2, Q8N6Q2, Q96M39, Q96SD4	Gene names	DMRTC2
Domain Architecture	No domain graphic available
Description	Doublesex- and mab-3-related transcription factor C2.

NRAM1_MOUSE
θ value	0.47712 (rank : 16)	NC score	0.033878 (rank : 30)
Query Neighborhood Hits	81	Target Neighborhood Hits	10	Shared Neighborhood Hits	2
SwissProt Accessions	P41251	Gene names	Slc11a1, Bcg, Ity, Lsh, Nramp1
Domain Architecture
Description	Natural resistance-associated macrophage protein 1 (NRAMP 1).

ZN385_HUMAN
θ value	0.47712 (rank : 17)	NC score	0.056750 (rank : 13)
Query Neighborhood Hits	81	Target Neighborhood Hits	614	Shared Neighborhood Hits	21
SwissProt Accessions	Q96PM9, Q5VH53, Q9H7R6, Q9UFU3	Gene names	ZNF385, HZF, RZF
Domain Architecture
Description	Zinc finger protein 385 (Hematopoietic zinc finger protein) (Retinal zinc finger protein).

CRSP2_HUMAN
θ value	0.62314 (rank : 18)	NC score	0.056377 (rank : 14)
Query Neighborhood Hits	81	Target Neighborhood Hits	380	Shared Neighborhood Hits	19
SwissProt Accessions	O60244, Q9UNB3	Gene names	CRSP2, ARC150, DRIP150, EXLM1, TRAP170
Domain Architecture	No domain graphic available
Description	CRSP complex subunit 2 (Cofactor required for Sp1 transcriptional activation subunit 2) (Transcriptional coactivator CRSP150) (Vitamin D3 receptor-interacting protein complex 150 kDa component) (DRIP150) (Thyroid hormone receptor-associated protein complex 170 kDa component) (Trap170) (Activator-recruited cofactor 150 kDa component) (ARC150).

CUTL2_MOUSE
θ value	0.62314 (rank : 19)	NC score	0.025620 (rank : 43)
Query Neighborhood Hits	81	Target Neighborhood Hits	771	Shared Neighborhood Hits	14
SwissProt Accessions	P70298	Gene names	Cutl2
Domain Architecture
Description	Homeobox protein cut-like 2 (Homeobox protein Cux-2) (Cut-like 2).

TNFC_MOUSE
θ value	0.62314 (rank : 20)	NC score	0.045389 (rank : 22)
Query Neighborhood Hits	81	Target Neighborhood Hits	31	Shared Neighborhood Hits	2
SwissProt Accessions	P41155	Gene names	Ltb, Tnfc, Tnfsf3
Domain Architecture
Description	Lymphotoxin-beta (LT-beta) (Tumor necrosis factor C) (TNF-C) (Tumor necrosis factor ligand superfamily member 3).

NCOR2_HUMAN
θ value	0.813845 (rank : 21)	NC score	0.031803 (rank : 31)
Query Neighborhood Hits	81	Target Neighborhood Hits	870	Shared Neighborhood Hits	24
SwissProt Accessions	Q9Y618, O00613, O15416, Q13354, Q9Y5U0	Gene names	NCOR2, CTG26
Domain Architecture
Description	Nuclear receptor corepressor 2 (N-CoR2) (Silencing mediator of retinoic acid and thyroid hormone receptor) (SMRT) (SMRTe) (Thyroid-, retinoic-acid-receptor-associated corepressor) (T3 receptor- associating factor) (TRAC) (CTG repeat protein 26) (SMAP270).

SPR1B_MOUSE
θ value	0.813845 (rank : 22)	NC score	0.028286 (rank : 38)
Query Neighborhood Hits	81	Target Neighborhood Hits	395	Shared Neighborhood Hits	15
SwissProt Accessions	Q62267	Gene names	Sprr1b
Domain Architecture
Description	Cornifin B (Small proline-rich protein 1B) (SPR1B) (SPR1 B).

SMAL1_MOUSE
θ value	1.06291 (rank : 23)	NC score	0.036923 (rank : 29)
Query Neighborhood Hits	81	Target Neighborhood Hits	157	Shared Neighborhood Hits	5
SwissProt Accessions	Q8BJL0, Q8BVK7, Q8BXW4, Q8K309, Q9EQK8, Q9QYC4	Gene names	Smarcal1, Harp
Domain Architecture	No domain graphic available
Description	SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A-like protein 1 (EC 3.6.1.-) (Sucrose nonfermenting protein 2-like 1) (HepA-related protein) (mharp).

DGKG_HUMAN
θ value	1.38821 (rank : 24)	NC score	0.054915 (rank : 16)
Query Neighborhood Hits	81	Target Neighborhood Hits	171	Shared Neighborhood Hits	11
SwissProt Accessions	P49619	Gene names	DGKG, DAGK3
Domain Architecture
Description	Diacylglycerol kinase gamma (EC 2.7.1.107) (Diglyceride kinase gamma) (DGK-gamma) (DAG kinase gamma).

PI5PA_HUMAN
θ value	1.38821 (rank : 25)	NC score	0.040014 (rank : 28)
Query Neighborhood Hits	81	Target Neighborhood Hits	749	Shared Neighborhood Hits	32
SwissProt Accessions	Q15735, Q32M61, Q6ZTH6, Q8N902, Q9UDT9	Gene names	PIB5PA, PIPP
Domain Architecture
Description	Phosphatidylinositol 4,5-bisphosphate 5-phosphatase A (EC 3.1.3.56).

ULK1_MOUSE
θ value	1.38821 (rank : 26)	NC score	0.003922 (rank : 76)
Query Neighborhood Hits	81	Target Neighborhood Hits	1214	Shared Neighborhood Hits	17
SwissProt Accessions	O70405, Q6PGB2	Gene names	Ulk1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase ULK1 (EC 2.7.11.1) (Unc-51-like kinase 1) (Serine/threonine-protein kinase Unc51.1).

ZN516_MOUSE
θ value	1.38821 (rank : 27)	NC score	0.007412 (rank : 72)
Query Neighborhood Hits	81	Target Neighborhood Hits	1197	Shared Neighborhood Hits	21
SwissProt Accessions	Q7TSH3	Gene names	Znf516, Kiaa0222, Zfp516
Domain Architecture
Description	Zinc finger protein 516.

CIC_HUMAN
θ value	1.81305 (rank : 28)	NC score	0.031531 (rank : 32)
Query Neighborhood Hits	81	Target Neighborhood Hits	992	Shared Neighborhood Hits	40
SwissProt Accessions	Q96RK0, Q7LGI1, Q9UEG5, Q9Y6T1	Gene names	CIC, KIAA0306
Domain Architecture	No domain graphic available
Description	Protein capicua homolog.

HRBL_HUMAN
θ value	1.81305 (rank : 29)	NC score	0.025961 (rank : 42)
Query Neighborhood Hits	81	Target Neighborhood Hits	179	Shared Neighborhood Hits	7
SwissProt Accessions	O95081, O75429, Q96AB9, Q96GL4	Gene names	HRBL, RABR
Domain Architecture
Description	HIV-1 Rev-binding protein-like protein (Rev/Rex activation domain- binding protein related) (RAB-R).

RTKN_HUMAN
θ value	1.81305 (rank : 30)	NC score	0.030638 (rank : 34)
Query Neighborhood Hits	81	Target Neighborhood Hits	97	Shared Neighborhood Hits	3
SwissProt Accessions	Q9BST9, Q8WVN1, Q96PT6, Q9HB05	Gene names	RTKN
Domain Architecture	No domain graphic available
Description	Rhotekin.

S23IP_MOUSE
θ value	1.81305 (rank : 31)	NC score	0.031428 (rank : 33)
Query Neighborhood Hits	81	Target Neighborhood Hits	363	Shared Neighborhood Hits	20
SwissProt Accessions	Q6NZC7, Q8BXY6	Gene names	Sec23ip
Domain Architecture	No domain graphic available
Description	SEC23-interacting protein.

DGKG_MOUSE
θ value	2.36792 (rank : 32)	NC score	0.050666 (rank : 18)
Query Neighborhood Hits	81	Target Neighborhood Hits	188	Shared Neighborhood Hits	12
SwissProt Accessions	Q91WG7	Gene names	Dgkg, Dagk3
Domain Architecture
Description	Diacylglycerol kinase gamma (EC 2.7.1.107) (Diglyceride kinase gamma) (DGK-gamma) (DAG kinase gamma) (88 kDa diacylglycerol kinase).

DMRTD_MOUSE
θ value	2.36792 (rank : 33)	NC score	0.042193 (rank : 25)
Query Neighborhood Hits	81	Target Neighborhood Hits	72	Shared Neighborhood Hits	4
SwissProt Accessions	Q8CGW9	Gene names	Dmrtc2, Dmrt7
Domain Architecture	No domain graphic available
Description	Doublesex- and mab-3-related transcription factor C2 (Doublesex- and mab-3-related transcription factor 7).

NRX2A_HUMAN
θ value	2.36792 (rank : 34)	NC score	0.029885 (rank : 36)
Query Neighborhood Hits	81	Target Neighborhood Hits	614	Shared Neighborhood Hits	22
SwissProt Accessions	Q9P2S2, Q9Y2D6	Gene names	NRXN2, KIAA0921
Domain Architecture
Description	Neurexin-2-alpha precursor (Neurexin II-alpha).

NRX2B_HUMAN
θ value	2.36792 (rank : 35)	NC score	0.043093 (rank : 24)
Query Neighborhood Hits	81	Target Neighborhood Hits	481	Shared Neighborhood Hits	21
SwissProt Accessions	P58401	Gene names	NRXN2
Domain Architecture	No domain graphic available
Description	Neurexin-2-beta precursor (Neurexin II-beta).

WDR46_MOUSE
θ value	2.36792 (rank : 36)	NC score	0.024806 (rank : 46)
Query Neighborhood Hits	81	Target Neighborhood Hits	243	Shared Neighborhood Hits	5
SwissProt Accessions	Q9Z0H1	Gene names	Wdr46, Bing4
Domain Architecture
Description	WD repeat protein 46 (WD repeat protein BING4).

CYLD_MOUSE
θ value	3.0926 (rank : 37)	NC score	0.022636 (rank : 50)
Query Neighborhood Hits	81	Target Neighborhood Hits	42	Shared Neighborhood Hits	2
SwissProt Accessions	Q80TQ2, Q80VB3, Q8BXZ3, Q8BYL9, Q8CGB0	Gene names	Cyld, Cyld1, Kiaa0849
Domain Architecture	No domain graphic available
Description	Probable ubiquitin carboxyl-terminal hydrolase CYLD (EC 3.1.2.15) (Ubiquitin thioesterase CYLD) (Ubiquitin-specific-processing protease CYLD) (Deubiquitinating enzyme CYLD).

DGKA_HUMAN
θ value	3.0926 (rank : 38)	NC score	0.056232 (rank : 15)
Query Neighborhood Hits	81	Target Neighborhood Hits	151	Shared Neighborhood Hits	10
SwissProt Accessions	P23743, O75481, O75482, O75483	Gene names	DGKA, DAGK, DAGK1
Domain Architecture
Description	Diacylglycerol kinase alpha (EC 2.7.1.107) (Diglyceride kinase alpha) (DGK-alpha) (DAG kinase alpha) (80 kDa diacylglycerol kinase).

IL4RA_MOUSE
θ value	3.0926 (rank : 39)	NC score	0.026675 (rank : 40)
Query Neighborhood Hits	81	Target Neighborhood Hits	194	Shared Neighborhood Hits	8
SwissProt Accessions	P16382, O54690, Q60583, Q8CBW5	Gene names	Il4r, Il4ra
Domain Architecture
Description	Interleukin-4 receptor alpha chain precursor (IL-4R-alpha) (CD124 antigen) [Contains: Soluble interleukin-4 receptor alpha chain (IL-4- binding protein) (IL4-BP)].

PTN5_MOUSE
θ value	3.0926 (rank : 40)	NC score	0.009786 (rank : 66)
Query Neighborhood Hits	81	Target Neighborhood Hits	85	Shared Neighborhood Hits	4
SwissProt Accessions	P54830, Q64694	Gene names	Ptpn5
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 5 (EC 3.1.3.48) (Protein-tyrosine phosphatase striatum-enriched) (STEP) (Neural- specific protein-tyrosine phosphatase).

CK035_HUMAN
θ value	4.03905 (rank : 41)	NC score	0.024279 (rank : 47)
Query Neighborhood Hits	81	Target Neighborhood Hits	149	Shared Neighborhood Hits	6
SwissProt Accessions	Q8IXW0	Gene names	C11orf35
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C11orf35.

CSKI2_HUMAN
θ value	4.03905 (rank : 42)	NC score	0.026612 (rank : 41)
Query Neighborhood Hits	81	Target Neighborhood Hits	747	Shared Neighborhood Hits	31
SwissProt Accessions	Q8WXE0, Q7LG69, Q9ULT1	Gene names	CASKIN2, KIAA1139
Domain Architecture	No domain graphic available
Description	Caskin-2.

CSPG3_HUMAN
θ value	4.03905 (rank : 43)	NC score	0.008317 (rank : 70)
Query Neighborhood Hits	81	Target Neighborhood Hits	676	Shared Neighborhood Hits	15
SwissProt Accessions	O14594, Q9UPK6	Gene names	CSPG3, NCAN, NEUR
Domain Architecture
Description	Neurocan core protein precursor (Chondroitin sulfate proteoglycan 3).

DAB1_HUMAN
θ value	4.03905 (rank : 44)	NC score	0.018012 (rank : 56)
Query Neighborhood Hits	81	Target Neighborhood Hits	219	Shared Neighborhood Hits	6
SwissProt Accessions	O75553, Q9NYA8	Gene names	DAB1
Domain Architecture
Description	Disabled homolog 1.

NACAM_MOUSE
θ value	4.03905 (rank : 45)	NC score	0.025318 (rank : 45)
Query Neighborhood Hits	81	Target Neighborhood Hits	1866	Shared Neighborhood Hits	41
SwissProt Accessions	P70670	Gene names	Naca
Domain Architecture	No domain graphic available
Description	Nascent polypeptide-associated complex subunit alpha, muscle-specific form (Alpha-NAC, muscle-specific form).

NCOA3_MOUSE
θ value	4.03905 (rank : 46)	NC score	0.014742 (rank : 58)
Query Neighborhood Hits	81	Target Neighborhood Hits	203	Shared Neighborhood Hits	8
SwissProt Accessions	O09000, Q9CRD5	Gene names	Ncoa3, Aib1, Pcip, Rac3, Tram1
Domain Architecture
Description	Nuclear receptor coactivator 3 (EC 2.3.1.48) (NCoA-3) (Thyroid hormone receptor activator molecule 1) (TRAM-1) (ACTR) (Receptor-associated coactivator 3) (RAC-3) (Amplified in breast cancer-1 protein homolog) (AIB-1) (Steroid receptor coactivator protein 3) (SRC-3) (CBP- interacting protein) (p/CIP) (pCIP).

PTN22_MOUSE
θ value	4.03905 (rank : 47)	NC score	0.009856 (rank : 65)
Query Neighborhood Hits	81	Target Neighborhood Hits	179	Shared Neighborhood Hits	8
SwissProt Accessions	P29352, Q7TMP9	Gene names	Ptpn22, Ptpn8
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 22 (EC 3.1.3.48) (Hematopoietic cell protein-tyrosine phosphatase 70Z-PEP).

ATX2_MOUSE
θ value	5.27518 (rank : 48)	NC score	0.022733 (rank : 49)
Query Neighborhood Hits	81	Target Neighborhood Hits	445	Shared Neighborhood Hits	19
SwissProt Accessions	O70305, P97421	Gene names	Atxn2, Atx2, Sca2
Domain Architecture	No domain graphic available
Description	Ataxin-2 (Spinocerebellar ataxia type 2 protein homolog).

CBP_MOUSE
θ value	5.27518 (rank : 49)	NC score	0.030548 (rank : 35)
Query Neighborhood Hits	81	Target Neighborhood Hits	1051	Shared Neighborhood Hits	32
SwissProt Accessions	P45481	Gene names	Crebbp, Cbp
Domain Architecture
Description	CREB-binding protein (EC 2.3.1.48).

CO7A1_HUMAN
θ value	5.27518 (rank : 50)	NC score	0.008473 (rank : 68)
Query Neighborhood Hits	81	Target Neighborhood Hits	807	Shared Neighborhood Hits	19
SwissProt Accessions	Q02388, Q14054, Q16507	Gene names	COL7A1
Domain Architecture
Description	Collagen alpha-1(VII) chain precursor (Long-chain collagen) (LC collagen).

DEN1A_MOUSE
θ value	5.27518 (rank : 51)	NC score	0.018899 (rank : 52)
Query Neighborhood Hits	81	Target Neighborhood Hits	178	Shared Neighborhood Hits	14
SwissProt Accessions	Q8K382	Gene names	Dennd1a
Domain Architecture	No domain graphic available
Description	DENN domain-containing protein 1A.

DGKZ_HUMAN
θ value	5.27518 (rank : 52)	NC score	0.049649 (rank : 21)
Query Neighborhood Hits	81	Target Neighborhood Hits	551	Shared Neighborhood Hits	13
SwissProt Accessions	Q13574, O00542	Gene names	DGKZ, DAGK6
Domain Architecture
Description	Diacylglycerol kinase zeta (EC 2.7.1.107) (Diglyceride kinase zeta) (DGK-zeta) (DAG kinase zeta).

DGKZ_MOUSE
θ value	5.27518 (rank : 53)	NC score	0.049880 (rank : 20)
Query Neighborhood Hits	81	Target Neighborhood Hits	542	Shared Neighborhood Hits	13
SwissProt Accessions	Q80UP3	Gene names	Dgkz
Domain Architecture
Description	Diacylglycerol kinase zeta (EC 2.7.1.107) (Diglyceride kinase zeta) (DGK-zeta) (DAG kinase zeta).

FIZ1_MOUSE
θ value	5.27518 (rank : 54)	NC score	0.000194 (rank : 81)
Query Neighborhood Hits	81	Target Neighborhood Hits	715	Shared Neighborhood Hits	5
SwissProt Accessions	Q9WTJ4, Q91W14, Q9CTG3	Gene names	Fiz1
Domain Architecture	No domain graphic available
Description	Flt3-interacting zinc finger protein 1.

LHX3_HUMAN
θ value	5.27518 (rank : 55)	NC score	0.008418 (rank : 69)
Query Neighborhood Hits	81	Target Neighborhood Hits	474	Shared Neighborhood Hits	8
SwissProt Accessions	Q9UBR4, Q9NZB5, Q9P0I8, Q9P0I9	Gene names	LHX3
Domain Architecture
Description	LIM/homeobox protein Lhx3.

OGFR_HUMAN
θ value	5.27518 (rank : 56)	NC score	0.023147 (rank : 48)
Query Neighborhood Hits	81	Target Neighborhood Hits	1582	Shared Neighborhood Hits	35
SwissProt Accessions	Q9NZT2, O96029, Q4VXW5, Q96CM2, Q9BQW1, Q9H4H0, Q9H7J5, Q9NZT3, Q9NZT4	Gene names	OGFR
Domain Architecture
Description	Opioid growth factor receptor (OGFr) (Zeta-type opioid receptor) (7-60 protein).

BAI2_HUMAN
θ value	6.88961 (rank : 57)	NC score	0.005922 (rank : 75)
Query Neighborhood Hits	81	Target Neighborhood Hits	332	Shared Neighborhood Hits	7
SwissProt Accessions	O60241, Q5T6K0, Q8NGW8	Gene names	BAI2
Domain Architecture
Description	Brain-specific angiogenesis inhibitor 2 precursor.

BIM_HUMAN
θ value	6.88961 (rank : 58)	NC score	0.019410 (rank : 51)
Query Neighborhood Hits	81	Target Neighborhood Hits	134	Shared Neighborhood Hits	6
SwissProt Accessions	O43521, O43522	Gene names	BCL2L11, BIM
Domain Architecture
Description	Bcl-2-like protein 11 (Bcl2-interacting mediator of cell death).

CAC1B_MOUSE
θ value	6.88961 (rank : 59)	NC score	0.009939 (rank : 64)
Query Neighborhood Hits	81	Target Neighborhood Hits	351	Shared Neighborhood Hits	12
SwissProt Accessions	O55017, Q60609	Gene names	Cacna1b, Cach5, Cacnl1a5, Cchn1a
Domain Architecture
Description	Voltage-dependent N-type calcium channel subunit alpha-1B (Voltage- gated calcium channel subunit alpha Cav2.2) (Calcium channel, L type, alpha-1 polypeptide isoform 5) (Brain calcium channel III) (BIII).

CBP_HUMAN
θ value	6.88961 (rank : 60)	NC score	0.027447 (rank : 39)
Query Neighborhood Hits	81	Target Neighborhood Hits	941	Shared Neighborhood Hits	35
SwissProt Accessions	Q92793, O00147, Q16376	Gene names	CREBBP, CBP
Domain Architecture
Description	CREB-binding protein (EC 2.3.1.48).

CSF1_HUMAN
θ value	6.88961 (rank : 61)	NC score	0.018861 (rank : 53)
Query Neighborhood Hits	81	Target Neighborhood Hits	258	Shared Neighborhood Hits	11
SwissProt Accessions	P09603, Q13130, Q14086, Q14806, Q9UQR8	Gene names	CSF1
Domain Architecture
Description	Macrophage colony-stimulating factor 1 precursor (CSF-1) (MCSF) (M- CSF) (Lanimostim).

DGKA_MOUSE
θ value	6.88961 (rank : 62)	NC score	0.043896 (rank : 23)
Query Neighborhood Hits	81	Target Neighborhood Hits	146	Shared Neighborhood Hits	11
SwissProt Accessions	O88673, Q922X2	Gene names	Dgka, Dagk1
Domain Architecture
Description	Diacylglycerol kinase alpha (EC 2.7.1.107) (Diglyceride kinase alpha) (DGK-alpha) (DAG kinase alpha) (80 kDa diacylglycerol kinase).

IGHE_HUMAN
θ value	6.88961 (rank : 63)	NC score	0.007558 (rank : 71)
Query Neighborhood Hits	81	Target Neighborhood Hits	217	Shared Neighborhood Hits	2
SwissProt Accessions	P01854	Gene names	IGHE
Domain Architecture
Description	Ig epsilon chain C region.

M3K14_MOUSE
θ value	6.88961 (rank : 64)	NC score	0.002046 (rank : 80)
Query Neighborhood Hits	81	Target Neighborhood Hits	889	Shared Neighborhood Hits	9
SwissProt Accessions	Q9WUL6	Gene names	Map3k14, Nik
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 14 (EC 2.7.11.25) (NF- kappa beta-inducing kinase) (Serine/threonine-protein kinase NIK).

MAGB6_HUMAN
θ value	6.88961 (rank : 65)	NC score	0.006731 (rank : 73)
Query Neighborhood Hits	81	Target Neighborhood Hits	184	Shared Neighborhood Hits	7
SwissProt Accessions	Q8N7X4, Q6GS19, Q9H219	Gene names	MAGEB6
Domain Architecture
Description	Melanoma-associated antigen B6 (MAGE-B6 antigen).

MGR5_HUMAN
θ value	6.88961 (rank : 66)	NC score	0.006133 (rank : 74)
Query Neighborhood Hits	81	Target Neighborhood Hits	72	Shared Neighborhood Hits	3
SwissProt Accessions	P41594	Gene names	GRM5, GPRC1E, MGLUR5
Domain Architecture
Description	Metabotropic glutamate receptor 5 precursor (mGluR5).

TCGAP_HUMAN
θ value	6.88961 (rank : 67)	NC score	0.010743 (rank : 61)
Query Neighborhood Hits	81	Target Neighborhood Hits	872	Shared Neighborhood Hits	24
SwissProt Accessions	O14559, O14552, O14560, Q6ZSP6, Q96CP3, Q9NT23	Gene names	SNX26, TCGAP
Domain Architecture
Description	TC10/CDC42 GTPase-activating protein (Sorting nexin-26).

ZC3H3_HUMAN
θ value	6.88961 (rank : 68)	NC score	0.013965 (rank : 59)
Query Neighborhood Hits	81	Target Neighborhood Hits	159	Shared Neighborhood Hits	5
SwissProt Accessions	Q8IXZ2, Q14163, Q8N4E2, Q9BUS4	Gene names	ZC3H3, KIAA0150, ZC3HDC3
Domain Architecture	No domain graphic available
Description	Zinc finger CCCH domain-containing protein 3.

AKAP2_HUMAN
θ value	8.99809 (rank : 69)	NC score	0.010514 (rank : 62)
Query Neighborhood Hits	81	Target Neighborhood Hits	507	Shared Neighborhood Hits	7
SwissProt Accessions	Q9Y2D5, Q9UG26	Gene names	AKAP2, KIAA0920
Domain Architecture	No domain graphic available
Description	A-kinase anchor protein 2 (Protein kinase A-anchoring protein 2) (PRKA2) (AKAP-2).

ARAF_HUMAN
θ value	8.99809 (rank : 70)	NC score	0.000139 (rank : 82)
Query Neighborhood Hits	81	Target Neighborhood Hits	924	Shared Neighborhood Hits	10
SwissProt Accessions	P10398, P07557, Q5H9B3	Gene names	ARAF, ARAF1, PKS, PKS2
Domain Architecture
Description	A-Raf proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1) (A- raf-1) (Proto-oncogene Pks).

CNOT4_HUMAN
θ value	8.99809 (rank : 71)	NC score	0.018851 (rank : 54)
Query Neighborhood Hits	81	Target Neighborhood Hits	207	Shared Neighborhood Hits	6
SwissProt Accessions	O95628, O95339, O95627, Q8IYM7, Q8NCL0, Q9NPQ1, Q9NZN6	Gene names	CNOT4, NOT4
Domain Architecture
Description	CCR4-NOT transcription complex subunit 4 (EC 6.3.2.-) (E3 ubiquitin protein ligase CNOT4) (CCR4-associated factor 4) (Potential transcriptional repressor NOT4Hp).

CNOT4_MOUSE
θ value	8.99809 (rank : 72)	NC score	0.018117 (rank : 55)
Query Neighborhood Hits	81	Target Neighborhood Hits	277	Shared Neighborhood Hits	7
SwissProt Accessions	Q8BT14, Q8CCR4, Q9CV74, Q9Z1D0	Gene names	Cnot4, Not4
Domain Architecture
Description	CCR4-NOT transcription complex subunit 4 (EC 6.3.2.-) (E3 ubiquitin protein ligase CNOT4) (CCR4-associated factor 4) (Potential transcriptional repressor NOT4Hp).

DGKB_HUMAN
θ value	8.99809 (rank : 73)	NC score	0.041369 (rank : 26)
Query Neighborhood Hits	81	Target Neighborhood Hits	238	Shared Neighborhood Hits	11
SwissProt Accessions	Q9Y6T7, O75241, Q75MF9, Q75MU7, Q86UI5, Q86UM9, Q9UQ29	Gene names	DGKB, DAGK2, KIAA0718
Domain Architecture
Description	Diacylglycerol kinase beta (EC 2.7.1.107) (Diglyceride kinase beta) (DGK-beta) (DAG kinase beta) (90 kDa diacylglycerol kinase).

HXB4_MOUSE
θ value	8.99809 (rank : 74)	NC score	0.003808 (rank : 77)
Query Neighborhood Hits	81	Target Neighborhood Hits	375	Shared Neighborhood Hits	12
SwissProt Accessions	P10284, Q3UZB4, Q4VBG0	Gene names	Hoxb4, Hox-2.6, Hoxb-4
Domain Architecture
Description	Homeobox protein Hox-B4 (Hox-2.6).

ITIH4_HUMAN
θ value	8.99809 (rank : 75)	NC score	0.008853 (rank : 67)
Query Neighborhood Hits	81	Target Neighborhood Hits	46	Shared Neighborhood Hits	3
SwissProt Accessions	Q14624, Q15135, Q9P190, Q9UQ54	Gene names	ITIH4, IHRP, ITIHL1, PK120
Domain Architecture
Description	Inter-alpha-trypsin inhibitor heavy chain H4 precursor (ITI heavy chain H4) (Inter-alpha-inhibitor heavy chain 4) (Inter-alpha-trypsin inhibitor family heavy chain-related protein) (IHRP) (Plasma kallikrein sensitive glycoprotein 120) (PK-120) (GP120) [Contains: 70 kDa inter-alpha-trypsin inhibitor heavy chain H4; 35 kDa inter-alpha- trypsin inhibitor heavy chain H4].

KIFC3_HUMAN
θ value	8.99809 (rank : 76)	NC score	0.002085 (rank : 79)
Query Neighborhood Hits	81	Target Neighborhood Hits	619	Shared Neighborhood Hits	4
SwissProt Accessions	Q9BVG8, O75299, Q8IUT3, Q96HW6	Gene names	KIFC3
Domain Architecture
Description	Kinesin-like protein KIFC3.

LAP4_HUMAN
θ value	8.99809 (rank : 77)	NC score	0.003141 (rank : 78)
Query Neighborhood Hits	81	Target Neighborhood Hits	608	Shared Neighborhood Hits	9
SwissProt Accessions	Q14160, Q6P496, Q7Z5D1, Q8WWV8, Q96C69, Q96GG1	Gene names	SCRIB, CRIB1, KIAA0147, LAP4, SCRB1, VARTUL
Domain Architecture	No domain graphic available
Description	Protein LAP4 (Protein scribble homolog) (hScrib).

MEGF9_MOUSE
θ value	8.99809 (rank : 78)	NC score	0.010464 (rank : 63)
Query Neighborhood Hits	81	Target Neighborhood Hits	896	Shared Neighborhood Hits	24
SwissProt Accessions	Q8BH27, Q8BWI4	Gene names	Megf9, Egfl5, Kiaa0818
Domain Architecture
Description	Multiple epidermal growth factor-like domains 9 precursor (EGF-like domain-containing protein 5) (Multiple EGF-like domain protein 5).

SC24A_MOUSE
θ value	8.99809 (rank : 79)	NC score	0.016611 (rank : 57)
Query Neighborhood Hits	81	Target Neighborhood Hits	394	Shared Neighborhood Hits	15
SwissProt Accessions	Q3U2P1, Q3TQ05, Q3TRG7, Q8BIS0	Gene names	Sec24a
Domain Architecture	No domain graphic available
Description	Protein transport protein Sec24A (SEC24-related protein A).

SOX30_MOUSE
θ value	8.99809 (rank : 80)	NC score	0.011555 (rank : 60)
Query Neighborhood Hits	81	Target Neighborhood Hits	374	Shared Neighborhood Hits	11
SwissProt Accessions	Q8CGW4	Gene names	Sox30
Domain Architecture
Description	Transcription factor SOX-30.

ZBT16_HUMAN
θ value	8.99809 (rank : 81)	NC score	-0.000804 (rank : 83)
Query Neighborhood Hits	81	Target Neighborhood Hits	1010	Shared Neighborhood Hits	11
SwissProt Accessions	Q05516, Q8TAL4	Gene names	ZBTB16, PLZF, ZNF145
Domain Architecture
Description	Zinc finger and BTB domain-containing protein 16 (Zinc finger protein PLZF) (Promyelocytic leukemia zinc finger protein) (Zinc finger protein 145).

CXX1_HUMAN
θ value	θ > 10 (rank : 82)	NC score	0.050032 (rank : 19)
Query Neighborhood Hits	81	Target Neighborhood Hits	17	Shared Neighborhood Hits	1
SwissProt Accessions	O15255	Gene names	CXX1
Domain Architecture	No domain graphic available
Description	CAAX box protein 1 (Cerebral protein 5).

PRRT3_MOUSE
θ value	θ > 10 (rank : 83)	NC score	0.060523 (rank : 12)
Query Neighborhood Hits	81	Target Neighborhood Hits	162	Shared Neighborhood Hits	15
SwissProt Accessions	Q6PE13	Gene names	Prrt3
Domain Architecture	No domain graphic available
Description	Proline-rich transmembrane protein 3.

Hits sorted by NC score

SPHK2_HUMAN
NC score	0.999962 (rank : 1)	θ value	0 (rank : 1)
Query Neighborhood Hits	81	Target Neighborhood Hits	81	Shared Neighborhood Hits	81
SwissProt Accessions	Q9NRA0, Q9BRN1, Q9H0Q2, Q9NWU7	Gene names	SPHK2
Domain Architecture
Description	Sphingosine kinase 2 (EC 2.7.1.-) (SK 2) (SPK 2).

SPHK2_MOUSE
NC score	0.978938 (rank : 2)	θ value	0 (rank : 2)
Query Neighborhood Hits	81	Target Neighborhood Hits	78	Shared Neighborhood Hits	25
SwissProt Accessions	Q9JIA7, Q91VA9, Q9DBH6	Gene names	Sphk2
Domain Architecture
Description	Sphingosine kinase 2 (EC 2.7.1.-) (SK 2) (SPK 2).

SPHK1_HUMAN
NC score	0.903900 (rank : 3)	θ value	3.974e-56 (rank : 3)
Query Neighborhood Hits	81	Target Neighborhood Hits	15	Shared Neighborhood Hits	9
SwissProt Accessions	Q9NYA1, Q9HD92, Q9NY70, Q9NYL3	Gene names	SPHK1, SPHK, SPK
Domain Architecture
Description	Sphingosine kinase 1 (EC 2.7.1.-) (SK 1) (SPK 1).

CERK1_HUMAN
NC score	0.655657 (rank : 4)	θ value	8.36355e-22 (rank : 4)
Query Neighborhood Hits	81	Target Neighborhood Hits	10	Shared Neighborhood Hits	8
SwissProt Accessions	Q8TCT0, Q9BYB3, Q9UGE5	Gene names	CERK, KIAA1646
Domain Architecture
Description	Ceramide kinase (EC 2.7.1.138) (Acylsphingosine kinase) (hCERK) (Lipid kinase 4) (LK4).

CERK1_MOUSE
NC score	0.641539 (rank : 5)	θ value	1.33526e-19 (rank : 5)
Query Neighborhood Hits	81	Target Neighborhood Hits	17	Shared Neighborhood Hits	9
SwissProt Accessions	Q8K4Q7	Gene names	Cerk
Domain Architecture
Description	Ceramide kinase (EC 2.7.1.138) (Acylsphingosine kinase) (mCERK).

MULK_HUMAN
NC score	0.563451 (rank : 6)	θ value	4.59992e-12 (rank : 6)
Query Neighborhood Hits	81	Target Neighborhood Hits	13	Shared Neighborhood Hits	9
SwissProt Accessions	Q53H12, Q75KN1, Q96GC3, Q9NP48	Gene names	MULK, AGK
Domain Architecture	No domain graphic available
Description	Multiple substrate lipid kinase, mitochondrial precursor (EC 2.7.1.94) (EC 2.7.1.107) (Multi-substrate lipid kinase) (MuLK) (HsMuLK) (Acylglycerol kinase) (hAGK).

MULK_MOUSE
NC score	0.559769 (rank : 7)	θ value	1.33837e-11 (rank : 7)
Query Neighborhood Hits	81	Target Neighborhood Hits	10	Shared Neighborhood Hits	9
SwissProt Accessions	Q9ESW4, Q9D087	Gene names	Mulk
Domain Architecture	No domain graphic available
Description	Multiple substrate lipid kinase, mitochondrial precursor (EC 2.7.1.94) (EC 2.7.1.107) (Multi-substrate lipid kinase) (MuLK).

CERKL_HUMAN
NC score	0.457536 (rank : 8)	θ value	4.1701e-05 (rank : 8)
Query Neighborhood Hits	81	Target Neighborhood Hits	14	Shared Neighborhood Hits	8
SwissProt Accessions	Q49MI3, Q49MH9, Q49MI0, Q49MI1, Q49MI2, Q5DVJ2, Q5DVJ4, Q5DVJ5, Q6UZF6, Q6ZP59	Gene names	CERKL
Domain Architecture	No domain graphic available
Description	Ceramide kinase-like protein.

PRRT3_HUMAN
NC score	0.081382 (rank : 9)	θ value	0.00390308 (rank : 9)
Query Neighborhood Hits	81	Target Neighborhood Hits	998	Shared Neighborhood Hits	32
SwissProt Accessions	Q5FWE3, Q49AD0, Q6UXY6, Q8NBC9	Gene names	PRRT3, UNQ5823/PRO19642
Domain Architecture	No domain graphic available
Description	Proline-rich transmembrane protein 3.

DGKI_HUMAN
NC score	0.075055 (rank : 10)	θ value	0.163984 (rank : 11)
Query Neighborhood Hits	81	Target Neighborhood Hits	609	Shared Neighborhood Hits	16
SwissProt Accessions	O75912, Q9NZ49	Gene names	DGKI
Domain Architecture
Description	Diacylglycerol kinase iota (EC 2.7.1.107) (Diglyceride kinase iota) (DGK-iota) (DAG kinase iota).

ERCC1_HUMAN
NC score	0.061408 (rank : 11)	θ value	0.163984 (rank : 12)
Query Neighborhood Hits	81	Target Neighborhood Hits	34	Shared Neighborhood Hits	4
SwissProt Accessions	P07992	Gene names	ERCC1
Domain Architecture
Description	DNA excision repair protein ERCC-1.

PRRT3_MOUSE
NC score	0.060523 (rank : 12)	θ value	θ > 10 (rank : 83)
Query Neighborhood Hits	81	Target Neighborhood Hits	162	Shared Neighborhood Hits	15
SwissProt Accessions	Q6PE13	Gene names	Prrt3
Domain Architecture	No domain graphic available
Description	Proline-rich transmembrane protein 3.

ZN385_HUMAN
NC score	0.056750 (rank : 13)	θ value	0.47712 (rank : 17)
Query Neighborhood Hits	81	Target Neighborhood Hits	614	Shared Neighborhood Hits	21
SwissProt Accessions	Q96PM9, Q5VH53, Q9H7R6, Q9UFU3	Gene names	ZNF385, HZF, RZF
Domain Architecture
Description	Zinc finger protein 385 (Hematopoietic zinc finger protein) (Retinal zinc finger protein).

CRSP2_HUMAN
NC score	0.056377 (rank : 14)	θ value	0.62314 (rank : 18)
Query Neighborhood Hits	81	Target Neighborhood Hits	380	Shared Neighborhood Hits	19
SwissProt Accessions	O60244, Q9UNB3	Gene names	CRSP2, ARC150, DRIP150, EXLM1, TRAP170
Domain Architecture	No domain graphic available
Description	CRSP complex subunit 2 (Cofactor required for Sp1 transcriptional activation subunit 2) (Transcriptional coactivator CRSP150) (Vitamin D3 receptor-interacting protein complex 150 kDa component) (DRIP150) (Thyroid hormone receptor-associated protein complex 170 kDa component) (Trap170) (Activator-recruited cofactor 150 kDa component) (ARC150).

DGKA_HUMAN
NC score	0.056232 (rank : 15)	θ value	3.0926 (rank : 38)
Query Neighborhood Hits	81	Target Neighborhood Hits	151	Shared Neighborhood Hits	10
SwissProt Accessions	P23743, O75481, O75482, O75483	Gene names	DGKA, DAGK, DAGK1
Domain Architecture
Description	Diacylglycerol kinase alpha (EC 2.7.1.107) (Diglyceride kinase alpha) (DGK-alpha) (DAG kinase alpha) (80 kDa diacylglycerol kinase).

DGKG_HUMAN
NC score	0.054915 (rank : 16)	θ value	1.38821 (rank : 24)
Query Neighborhood Hits	81	Target Neighborhood Hits	171	Shared Neighborhood Hits	11
SwissProt Accessions	P49619	Gene names	DGKG, DAGK3
Domain Architecture
Description	Diacylglycerol kinase gamma (EC 2.7.1.107) (Diglyceride kinase gamma) (DGK-gamma) (DAG kinase gamma).

DMRTD_HUMAN
NC score	0.051503 (rank : 17)	θ value	0.47712 (rank : 15)
Query Neighborhood Hits	81	Target Neighborhood Hits	216	Shared Neighborhood Hits	13
SwissProt Accessions	Q8IXT2, Q8N6Q2, Q96M39, Q96SD4	Gene names	DMRTC2
Domain Architecture	No domain graphic available
Description	Doublesex- and mab-3-related transcription factor C2.

DGKG_MOUSE
NC score	0.050666 (rank : 18)	θ value	2.36792 (rank : 32)
Query Neighborhood Hits	81	Target Neighborhood Hits	188	Shared Neighborhood Hits	12
SwissProt Accessions	Q91WG7	Gene names	Dgkg, Dagk3
Domain Architecture
Description	Diacylglycerol kinase gamma (EC 2.7.1.107) (Diglyceride kinase gamma) (DGK-gamma) (DAG kinase gamma) (88 kDa diacylglycerol kinase).

CXX1_HUMAN
NC score	0.050032 (rank : 19)	θ value	θ > 10 (rank : 82)
Query Neighborhood Hits	81	Target Neighborhood Hits	17	Shared Neighborhood Hits	1
SwissProt Accessions	O15255	Gene names	CXX1
Domain Architecture	No domain graphic available
Description	CAAX box protein 1 (Cerebral protein 5).

DGKZ_MOUSE
NC score	0.049880 (rank : 20)	θ value	5.27518 (rank : 53)
Query Neighborhood Hits	81	Target Neighborhood Hits	542	Shared Neighborhood Hits	13
SwissProt Accessions	Q80UP3	Gene names	Dgkz
Domain Architecture
Description	Diacylglycerol kinase zeta (EC 2.7.1.107) (Diglyceride kinase zeta) (DGK-zeta) (DAG kinase zeta).

DGKZ_HUMAN
NC score	0.049649 (rank : 21)	θ value	5.27518 (rank : 52)
Query Neighborhood Hits	81	Target Neighborhood Hits	551	Shared Neighborhood Hits	13
SwissProt Accessions	Q13574, O00542	Gene names	DGKZ, DAGK6
Domain Architecture
Description	Diacylglycerol kinase zeta (EC 2.7.1.107) (Diglyceride kinase zeta) (DGK-zeta) (DAG kinase zeta).

TNFC_MOUSE
NC score	0.045389 (rank : 22)	θ value	0.62314 (rank : 20)
Query Neighborhood Hits	81	Target Neighborhood Hits	31	Shared Neighborhood Hits	2
SwissProt Accessions	P41155	Gene names	Ltb, Tnfc, Tnfsf3
Domain Architecture
Description	Lymphotoxin-beta (LT-beta) (Tumor necrosis factor C) (TNF-C) (Tumor necrosis factor ligand superfamily member 3).

DGKA_MOUSE
NC score	0.043896 (rank : 23)	θ value	6.88961 (rank : 62)
Query Neighborhood Hits	81	Target Neighborhood Hits	146	Shared Neighborhood Hits	11
SwissProt Accessions	O88673, Q922X2	Gene names	Dgka, Dagk1
Domain Architecture
Description	Diacylglycerol kinase alpha (EC 2.7.1.107) (Diglyceride kinase alpha) (DGK-alpha) (DAG kinase alpha) (80 kDa diacylglycerol kinase).

NRX2B_HUMAN
NC score	0.043093 (rank : 24)	θ value	2.36792 (rank : 35)
Query Neighborhood Hits	81	Target Neighborhood Hits	481	Shared Neighborhood Hits	21
SwissProt Accessions	P58401	Gene names	NRXN2
Domain Architecture	No domain graphic available
Description	Neurexin-2-beta precursor (Neurexin II-beta).

DMRTD_MOUSE
NC score	0.042193 (rank : 25)	θ value	2.36792 (rank : 33)
Query Neighborhood Hits	81	Target Neighborhood Hits	72	Shared Neighborhood Hits	4
SwissProt Accessions	Q8CGW9	Gene names	Dmrtc2, Dmrt7
Domain Architecture	No domain graphic available
Description	Doublesex- and mab-3-related transcription factor C2 (Doublesex- and mab-3-related transcription factor 7).

DGKB_HUMAN
NC score	0.041369 (rank : 26)	θ value	8.99809 (rank : 73)
Query Neighborhood Hits	81	Target Neighborhood Hits	238	Shared Neighborhood Hits	11
SwissProt Accessions	Q9Y6T7, O75241, Q75MF9, Q75MU7, Q86UI5, Q86UM9, Q9UQ29	Gene names	DGKB, DAGK2, KIAA0718
Domain Architecture
Description	Diacylglycerol kinase beta (EC 2.7.1.107) (Diglyceride kinase beta) (DGK-beta) (DAG kinase beta) (90 kDa diacylglycerol kinase).

SON_HUMAN
NC score	0.040433 (rank : 27)	θ value	0.279714 (rank : 13)
Query Neighborhood Hits	81	Target Neighborhood Hits	1568	Shared Neighborhood Hits	28
SwissProt Accessions	P18583, O14487, O95981, Q14120, Q9H7B1, Q9P070, Q9P072, Q9UKP9, Q9UPY0	Gene names	SON, C21orf50, DBP5, KIAA1019, NREBP
Domain Architecture
Description	SON protein (SON3) (Negative regulatory element-binding protein) (NRE- binding protein) (DBP-5) (Bax antagonist selected in saccharomyces 1) (BASS1).

PI5PA_HUMAN
NC score	0.040014 (rank : 28)	θ value	1.38821 (rank : 25)
Query Neighborhood Hits	81	Target Neighborhood Hits	749	Shared Neighborhood Hits	32
SwissProt Accessions	Q15735, Q32M61, Q6ZTH6, Q8N902, Q9UDT9	Gene names	PIB5PA, PIPP
Domain Architecture
Description	Phosphatidylinositol 4,5-bisphosphate 5-phosphatase A (EC 3.1.3.56).

SMAL1_MOUSE
NC score	0.036923 (rank : 29)	θ value	1.06291 (rank : 23)
Query Neighborhood Hits	81	Target Neighborhood Hits	157	Shared Neighborhood Hits	5
SwissProt Accessions	Q8BJL0, Q8BVK7, Q8BXW4, Q8K309, Q9EQK8, Q9QYC4	Gene names	Smarcal1, Harp
Domain Architecture	No domain graphic available
Description	SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A-like protein 1 (EC 3.6.1.-) (Sucrose nonfermenting protein 2-like 1) (HepA-related protein) (mharp).

NRAM1_MOUSE
NC score	0.033878 (rank : 30)	θ value	0.47712 (rank : 16)
Query Neighborhood Hits	81	Target Neighborhood Hits	10	Shared Neighborhood Hits	2
SwissProt Accessions	P41251	Gene names	Slc11a1, Bcg, Ity, Lsh, Nramp1
Domain Architecture
Description	Natural resistance-associated macrophage protein 1 (NRAMP 1).

NCOR2_HUMAN
NC score	0.031803 (rank : 31)	θ value	0.813845 (rank : 21)
Query Neighborhood Hits	81	Target Neighborhood Hits	870	Shared Neighborhood Hits	24
SwissProt Accessions	Q9Y618, O00613, O15416, Q13354, Q9Y5U0	Gene names	NCOR2, CTG26
Domain Architecture
Description	Nuclear receptor corepressor 2 (N-CoR2) (Silencing mediator of retinoic acid and thyroid hormone receptor) (SMRT) (SMRTe) (Thyroid-, retinoic-acid-receptor-associated corepressor) (T3 receptor- associating factor) (TRAC) (CTG repeat protein 26) (SMAP270).

CIC_HUMAN
NC score	0.031531 (rank : 32)	θ value	1.81305 (rank : 28)
Query Neighborhood Hits	81	Target Neighborhood Hits	992	Shared Neighborhood Hits	40
SwissProt Accessions	Q96RK0, Q7LGI1, Q9UEG5, Q9Y6T1	Gene names	CIC, KIAA0306
Domain Architecture	No domain graphic available
Description	Protein capicua homolog.

S23IP_MOUSE
NC score	0.031428 (rank : 33)	θ value	1.81305 (rank : 31)
Query Neighborhood Hits	81	Target Neighborhood Hits	363	Shared Neighborhood Hits	20
SwissProt Accessions	Q6NZC7, Q8BXY6	Gene names	Sec23ip
Domain Architecture	No domain graphic available
Description	SEC23-interacting protein.

RTKN_HUMAN
NC score	0.030638 (rank : 34)	θ value	1.81305 (rank : 30)
Query Neighborhood Hits	81	Target Neighborhood Hits	97	Shared Neighborhood Hits	3
SwissProt Accessions	Q9BST9, Q8WVN1, Q96PT6, Q9HB05	Gene names	RTKN
Domain Architecture	No domain graphic available
Description	Rhotekin.

CBP_MOUSE
NC score	0.030548 (rank : 35)	θ value	5.27518 (rank : 49)
Query Neighborhood Hits	81	Target Neighborhood Hits	1051	Shared Neighborhood Hits	32
SwissProt Accessions	P45481	Gene names	Crebbp, Cbp
Domain Architecture
Description	CREB-binding protein (EC 2.3.1.48).

NRX2A_HUMAN
NC score	0.029885 (rank : 36)	θ value	2.36792 (rank : 34)
Query Neighborhood Hits	81	Target Neighborhood Hits	614	Shared Neighborhood Hits	22
SwissProt Accessions	Q9P2S2, Q9Y2D6	Gene names	NRXN2, KIAA0921
Domain Architecture
Description	Neurexin-2-alpha precursor (Neurexin II-alpha).

GNAS1_MOUSE
NC score	0.029804 (rank : 37)	θ value	0.0563607 (rank : 10)
Query Neighborhood Hits	81	Target Neighborhood Hits	651	Shared Neighborhood Hits	25
SwissProt Accessions	Q6R0H7, Q6R0H4, Q6R0H5, Q6R2J5, Q9JJX0, Q9Z1N8	Gene names	Gnas, Gnas1
Domain Architecture	No domain graphic available
Description	Guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas (Adenylate cyclase-stimulating G alpha protein) (Extra large alphas protein) (XLalphas).

SPR1B_MOUSE
NC score	0.028286 (rank : 38)	θ value	0.813845 (rank : 22)
Query Neighborhood Hits	81	Target Neighborhood Hits	395	Shared Neighborhood Hits	15
SwissProt Accessions	Q62267	Gene names	Sprr1b
Domain Architecture
Description	Cornifin B (Small proline-rich protein 1B) (SPR1B) (SPR1 B).

CBP_HUMAN
NC score	0.027447 (rank : 39)	θ value	6.88961 (rank : 60)
Query Neighborhood Hits	81	Target Neighborhood Hits	941	Shared Neighborhood Hits	35
SwissProt Accessions	Q92793, O00147, Q16376	Gene names	CREBBP, CBP
Domain Architecture
Description	CREB-binding protein (EC 2.3.1.48).

IL4RA_MOUSE
NC score	0.026675 (rank : 40)	θ value	3.0926 (rank : 39)
Query Neighborhood Hits	81	Target Neighborhood Hits	194	Shared Neighborhood Hits	8
SwissProt Accessions	P16382, O54690, Q60583, Q8CBW5	Gene names	Il4r, Il4ra
Domain Architecture
Description	Interleukin-4 receptor alpha chain precursor (IL-4R-alpha) (CD124 antigen) [Contains: Soluble interleukin-4 receptor alpha chain (IL-4- binding protein) (IL4-BP)].

CSKI2_HUMAN
NC score	0.026612 (rank : 41)	θ value	4.03905 (rank : 42)
Query Neighborhood Hits	81	Target Neighborhood Hits	747	Shared Neighborhood Hits	31
SwissProt Accessions	Q8WXE0, Q7LG69, Q9ULT1	Gene names	CASKIN2, KIAA1139
Domain Architecture	No domain graphic available
Description	Caskin-2.

HRBL_HUMAN
NC score	0.025961 (rank : 42)	θ value	1.81305 (rank : 29)
Query Neighborhood Hits	81	Target Neighborhood Hits	179	Shared Neighborhood Hits	7
SwissProt Accessions	O95081, O75429, Q96AB9, Q96GL4	Gene names	HRBL, RABR
Domain Architecture
Description	HIV-1 Rev-binding protein-like protein (Rev/Rex activation domain- binding protein related) (RAB-R).

CUTL2_MOUSE
NC score	0.025620 (rank : 43)	θ value	0.62314 (rank : 19)
Query Neighborhood Hits	81	Target Neighborhood Hits	771	Shared Neighborhood Hits	14
SwissProt Accessions	P70298	Gene names	Cutl2
Domain Architecture
Description	Homeobox protein cut-like 2 (Homeobox protein Cux-2) (Cut-like 2).

CSKI1_MOUSE
NC score	0.025609 (rank : 44)	θ value	0.47712 (rank : 14)
Query Neighborhood Hits	81	Target Neighborhood Hits	1031	Shared Neighborhood Hits	31
SwissProt Accessions	Q6P9K8, Q6ZPU2, Q8BWU2, Q8BX99, Q9CXH0	Gene names	Caskin1, Kiaa1306
Domain Architecture	No domain graphic available
Description	Caskin-1 (CASK-interacting protein 1).

NACAM_MOUSE
NC score	0.025318 (rank : 45)	θ value	4.03905 (rank : 45)
Query Neighborhood Hits	81	Target Neighborhood Hits	1866	Shared Neighborhood Hits	41
SwissProt Accessions	P70670	Gene names	Naca
Domain Architecture	No domain graphic available
Description	Nascent polypeptide-associated complex subunit alpha, muscle-specific form (Alpha-NAC, muscle-specific form).

WDR46_MOUSE
NC score	0.024806 (rank : 46)	θ value	2.36792 (rank : 36)
Query Neighborhood Hits	81	Target Neighborhood Hits	243	Shared Neighborhood Hits	5
SwissProt Accessions	Q9Z0H1	Gene names	Wdr46, Bing4
Domain Architecture
Description	WD repeat protein 46 (WD repeat protein BING4).

CK035_HUMAN
NC score	0.024279 (rank : 47)	θ value	4.03905 (rank : 41)
Query Neighborhood Hits	81	Target Neighborhood Hits	149	Shared Neighborhood Hits	6
SwissProt Accessions	Q8IXW0	Gene names	C11orf35
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C11orf35.

OGFR_HUMAN
NC score	0.023147 (rank : 48)	θ value	5.27518 (rank : 56)
Query Neighborhood Hits	81	Target Neighborhood Hits	1582	Shared Neighborhood Hits	35
SwissProt Accessions	Q9NZT2, O96029, Q4VXW5, Q96CM2, Q9BQW1, Q9H4H0, Q9H7J5, Q9NZT3, Q9NZT4	Gene names	OGFR
Domain Architecture
Description	Opioid growth factor receptor (OGFr) (Zeta-type opioid receptor) (7-60 protein).

ATX2_MOUSE
NC score	0.022733 (rank : 49)	θ value	5.27518 (rank : 48)
Query Neighborhood Hits	81	Target Neighborhood Hits	445	Shared Neighborhood Hits	19
SwissProt Accessions	O70305, P97421	Gene names	Atxn2, Atx2, Sca2
Domain Architecture	No domain graphic available
Description	Ataxin-2 (Spinocerebellar ataxia type 2 protein homolog).

CYLD_MOUSE
NC score	0.022636 (rank : 50)	θ value	3.0926 (rank : 37)
Query Neighborhood Hits	81	Target Neighborhood Hits	42	Shared Neighborhood Hits	2
SwissProt Accessions	Q80TQ2, Q80VB3, Q8BXZ3, Q8BYL9, Q8CGB0	Gene names	Cyld, Cyld1, Kiaa0849
Domain Architecture	No domain graphic available
Description	Probable ubiquitin carboxyl-terminal hydrolase CYLD (EC 3.1.2.15) (Ubiquitin thioesterase CYLD) (Ubiquitin-specific-processing protease CYLD) (Deubiquitinating enzyme CYLD).

BIM_HUMAN
NC score	0.019410 (rank : 51)	θ value	6.88961 (rank : 58)
Query Neighborhood Hits	81	Target Neighborhood Hits	134	Shared Neighborhood Hits	6
SwissProt Accessions	O43521, O43522	Gene names	BCL2L11, BIM
Domain Architecture
Description	Bcl-2-like protein 11 (Bcl2-interacting mediator of cell death).

DEN1A_MOUSE
NC score	0.018899 (rank : 52)	θ value	5.27518 (rank : 51)
Query Neighborhood Hits	81	Target Neighborhood Hits	178	Shared Neighborhood Hits	14
SwissProt Accessions	Q8K382	Gene names	Dennd1a
Domain Architecture	No domain graphic available
Description	DENN domain-containing protein 1A.

CSF1_HUMAN
NC score	0.018861 (rank : 53)	θ value	6.88961 (rank : 61)
Query Neighborhood Hits	81	Target Neighborhood Hits	258	Shared Neighborhood Hits	11
SwissProt Accessions	P09603, Q13130, Q14086, Q14806, Q9UQR8	Gene names	CSF1
Domain Architecture
Description	Macrophage colony-stimulating factor 1 precursor (CSF-1) (MCSF) (M- CSF) (Lanimostim).

CNOT4_HUMAN
NC score	0.018851 (rank : 54)	θ value	8.99809 (rank : 71)
Query Neighborhood Hits	81	Target Neighborhood Hits	207	Shared Neighborhood Hits	6
SwissProt Accessions	O95628, O95339, O95627, Q8IYM7, Q8NCL0, Q9NPQ1, Q9NZN6	Gene names	CNOT4, NOT4
Domain Architecture
Description	CCR4-NOT transcription complex subunit 4 (EC 6.3.2.-) (E3 ubiquitin protein ligase CNOT4) (CCR4-associated factor 4) (Potential transcriptional repressor NOT4Hp).

CNOT4_MOUSE
NC score	0.018117 (rank : 55)	θ value	8.99809 (rank : 72)
Query Neighborhood Hits	81	Target Neighborhood Hits	277	Shared Neighborhood Hits	7
SwissProt Accessions	Q8BT14, Q8CCR4, Q9CV74, Q9Z1D0	Gene names	Cnot4, Not4
Domain Architecture
Description	CCR4-NOT transcription complex subunit 4 (EC 6.3.2.-) (E3 ubiquitin protein ligase CNOT4) (CCR4-associated factor 4) (Potential transcriptional repressor NOT4Hp).

DAB1_HUMAN
NC score	0.018012 (rank : 56)	θ value	4.03905 (rank : 44)
Query Neighborhood Hits	81	Target Neighborhood Hits	219	Shared Neighborhood Hits	6
SwissProt Accessions	O75553, Q9NYA8	Gene names	DAB1
Domain Architecture
Description	Disabled homolog 1.

SC24A_MOUSE
NC score	0.016611 (rank : 57)	θ value	8.99809 (rank : 79)
Query Neighborhood Hits	81	Target Neighborhood Hits	394	Shared Neighborhood Hits	15
SwissProt Accessions	Q3U2P1, Q3TQ05, Q3TRG7, Q8BIS0	Gene names	Sec24a
Domain Architecture	No domain graphic available
Description	Protein transport protein Sec24A (SEC24-related protein A).

NCOA3_MOUSE
NC score	0.014742 (rank : 58)	θ value	4.03905 (rank : 46)
Query Neighborhood Hits	81	Target Neighborhood Hits	203	Shared Neighborhood Hits	8
SwissProt Accessions	O09000, Q9CRD5	Gene names	Ncoa3, Aib1, Pcip, Rac3, Tram1
Domain Architecture
Description	Nuclear receptor coactivator 3 (EC 2.3.1.48) (NCoA-3) (Thyroid hormone receptor activator molecule 1) (TRAM-1) (ACTR) (Receptor-associated coactivator 3) (RAC-3) (Amplified in breast cancer-1 protein homolog) (AIB-1) (Steroid receptor coactivator protein 3) (SRC-3) (CBP- interacting protein) (p/CIP) (pCIP).

ZC3H3_HUMAN
NC score	0.013965 (rank : 59)	θ value	6.88961 (rank : 68)
Query Neighborhood Hits	81	Target Neighborhood Hits	159	Shared Neighborhood Hits	5
SwissProt Accessions	Q8IXZ2, Q14163, Q8N4E2, Q9BUS4	Gene names	ZC3H3, KIAA0150, ZC3HDC3
Domain Architecture	No domain graphic available
Description	Zinc finger CCCH domain-containing protein 3.

SOX30_MOUSE
NC score	0.011555 (rank : 60)	θ value	8.99809 (rank : 80)
Query Neighborhood Hits	81	Target Neighborhood Hits	374	Shared Neighborhood Hits	11
SwissProt Accessions	Q8CGW4	Gene names	Sox30
Domain Architecture
Description	Transcription factor SOX-30.

TCGAP_HUMAN
NC score	0.010743 (rank : 61)	θ value	6.88961 (rank : 67)
Query Neighborhood Hits	81	Target Neighborhood Hits	872	Shared Neighborhood Hits	24
SwissProt Accessions	O14559, O14552, O14560, Q6ZSP6, Q96CP3, Q9NT23	Gene names	SNX26, TCGAP
Domain Architecture
Description	TC10/CDC42 GTPase-activating protein (Sorting nexin-26).

AKAP2_HUMAN
NC score	0.010514 (rank : 62)	θ value	8.99809 (rank : 69)
Query Neighborhood Hits	81	Target Neighborhood Hits	507	Shared Neighborhood Hits	7
SwissProt Accessions	Q9Y2D5, Q9UG26	Gene names	AKAP2, KIAA0920
Domain Architecture	No domain graphic available
Description	A-kinase anchor protein 2 (Protein kinase A-anchoring protein 2) (PRKA2) (AKAP-2).

MEGF9_MOUSE
NC score	0.010464 (rank : 63)	θ value	8.99809 (rank : 78)
Query Neighborhood Hits	81	Target Neighborhood Hits	896	Shared Neighborhood Hits	24
SwissProt Accessions	Q8BH27, Q8BWI4	Gene names	Megf9, Egfl5, Kiaa0818
Domain Architecture
Description	Multiple epidermal growth factor-like domains 9 precursor (EGF-like domain-containing protein 5) (Multiple EGF-like domain protein 5).

CAC1B_MOUSE
NC score	0.009939 (rank : 64)	θ value	6.88961 (rank : 59)
Query Neighborhood Hits	81	Target Neighborhood Hits	351	Shared Neighborhood Hits	12
SwissProt Accessions	O55017, Q60609	Gene names	Cacna1b, Cach5, Cacnl1a5, Cchn1a
Domain Architecture
Description	Voltage-dependent N-type calcium channel subunit alpha-1B (Voltage- gated calcium channel subunit alpha Cav2.2) (Calcium channel, L type, alpha-1 polypeptide isoform 5) (Brain calcium channel III) (BIII).

PTN22_MOUSE
NC score	0.009856 (rank : 65)	θ value	4.03905 (rank : 47)
Query Neighborhood Hits	81	Target Neighborhood Hits	179	Shared Neighborhood Hits	8
SwissProt Accessions	P29352, Q7TMP9	Gene names	Ptpn22, Ptpn8
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 22 (EC 3.1.3.48) (Hematopoietic cell protein-tyrosine phosphatase 70Z-PEP).

PTN5_MOUSE
NC score	0.009786 (rank : 66)	θ value	3.0926 (rank : 40)
Query Neighborhood Hits	81	Target Neighborhood Hits	85	Shared Neighborhood Hits	4
SwissProt Accessions	P54830, Q64694	Gene names	Ptpn5
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 5 (EC 3.1.3.48) (Protein-tyrosine phosphatase striatum-enriched) (STEP) (Neural- specific protein-tyrosine phosphatase).

ITIH4_HUMAN
NC score	0.008853 (rank : 67)	θ value	8.99809 (rank : 75)
Query Neighborhood Hits	81	Target Neighborhood Hits	46	Shared Neighborhood Hits	3
SwissProt Accessions	Q14624, Q15135, Q9P190, Q9UQ54	Gene names	ITIH4, IHRP, ITIHL1, PK120
Domain Architecture
Description	Inter-alpha-trypsin inhibitor heavy chain H4 precursor (ITI heavy chain H4) (Inter-alpha-inhibitor heavy chain 4) (Inter-alpha-trypsin inhibitor family heavy chain-related protein) (IHRP) (Plasma kallikrein sensitive glycoprotein 120) (PK-120) (GP120) [Contains: 70 kDa inter-alpha-trypsin inhibitor heavy chain H4; 35 kDa inter-alpha- trypsin inhibitor heavy chain H4].

CO7A1_HUMAN
NC score	0.008473 (rank : 68)	θ value	5.27518 (rank : 50)
Query Neighborhood Hits	81	Target Neighborhood Hits	807	Shared Neighborhood Hits	19
SwissProt Accessions	Q02388, Q14054, Q16507	Gene names	COL7A1
Domain Architecture
Description	Collagen alpha-1(VII) chain precursor (Long-chain collagen) (LC collagen).

LHX3_HUMAN
NC score	0.008418 (rank : 69)	θ value	5.27518 (rank : 55)
Query Neighborhood Hits	81	Target Neighborhood Hits	474	Shared Neighborhood Hits	8
SwissProt Accessions	Q9UBR4, Q9NZB5, Q9P0I8, Q9P0I9	Gene names	LHX3
Domain Architecture
Description	LIM/homeobox protein Lhx3.

CSPG3_HUMAN
NC score	0.008317 (rank : 70)	θ value	4.03905 (rank : 43)
Query Neighborhood Hits	81	Target Neighborhood Hits	676	Shared Neighborhood Hits	15
SwissProt Accessions	O14594, Q9UPK6	Gene names	CSPG3, NCAN, NEUR
Domain Architecture
Description	Neurocan core protein precursor (Chondroitin sulfate proteoglycan 3).

IGHE_HUMAN
NC score	0.007558 (rank : 71)	θ value	6.88961 (rank : 63)
Query Neighborhood Hits	81	Target Neighborhood Hits	217	Shared Neighborhood Hits	2
SwissProt Accessions	P01854	Gene names	IGHE
Domain Architecture
Description	Ig epsilon chain C region.

ZN516_MOUSE
NC score	0.007412 (rank : 72)	θ value	1.38821 (rank : 27)
Query Neighborhood Hits	81	Target Neighborhood Hits	1197	Shared Neighborhood Hits	21
SwissProt Accessions	Q7TSH3	Gene names	Znf516, Kiaa0222, Zfp516
Domain Architecture
Description	Zinc finger protein 516.

MAGB6_HUMAN
NC score	0.006731 (rank : 73)	θ value	6.88961 (rank : 65)
Query Neighborhood Hits	81	Target Neighborhood Hits	184	Shared Neighborhood Hits	7
SwissProt Accessions	Q8N7X4, Q6GS19, Q9H219	Gene names	MAGEB6
Domain Architecture
Description	Melanoma-associated antigen B6 (MAGE-B6 antigen).

MGR5_HUMAN
NC score	0.006133 (rank : 74)	θ value	6.88961 (rank : 66)
Query Neighborhood Hits	81	Target Neighborhood Hits	72	Shared Neighborhood Hits	3
SwissProt Accessions	P41594	Gene names	GRM5, GPRC1E, MGLUR5
Domain Architecture
Description	Metabotropic glutamate receptor 5 precursor (mGluR5).

BAI2_HUMAN
NC score	0.005922 (rank : 75)	θ value	6.88961 (rank : 57)
Query Neighborhood Hits	81	Target Neighborhood Hits	332	Shared Neighborhood Hits	7
SwissProt Accessions	O60241, Q5T6K0, Q8NGW8	Gene names	BAI2
Domain Architecture
Description	Brain-specific angiogenesis inhibitor 2 precursor.

ULK1_MOUSE
NC score	0.003922 (rank : 76)	θ value	1.38821 (rank : 26)
Query Neighborhood Hits	81	Target Neighborhood Hits	1214	Shared Neighborhood Hits	17
SwissProt Accessions	O70405, Q6PGB2	Gene names	Ulk1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase ULK1 (EC 2.7.11.1) (Unc-51-like kinase 1) (Serine/threonine-protein kinase Unc51.1).

HXB4_MOUSE
NC score	0.003808 (rank : 77)	θ value	8.99809 (rank : 74)
Query Neighborhood Hits	81	Target Neighborhood Hits	375	Shared Neighborhood Hits	12
SwissProt Accessions	P10284, Q3UZB4, Q4VBG0	Gene names	Hoxb4, Hox-2.6, Hoxb-4
Domain Architecture
Description	Homeobox protein Hox-B4 (Hox-2.6).

LAP4_HUMAN
NC score	0.003141 (rank : 78)	θ value	8.99809 (rank : 77)
Query Neighborhood Hits	81	Target Neighborhood Hits	608	Shared Neighborhood Hits	9
SwissProt Accessions	Q14160, Q6P496, Q7Z5D1, Q8WWV8, Q96C69, Q96GG1	Gene names	SCRIB, CRIB1, KIAA0147, LAP4, SCRB1, VARTUL
Domain Architecture	No domain graphic available
Description	Protein LAP4 (Protein scribble homolog) (hScrib).

KIFC3_HUMAN
NC score	0.002085 (rank : 79)	θ value	8.99809 (rank : 76)
Query Neighborhood Hits	81	Target Neighborhood Hits	619	Shared Neighborhood Hits	4
SwissProt Accessions	Q9BVG8, O75299, Q8IUT3, Q96HW6	Gene names	KIFC3
Domain Architecture
Description	Kinesin-like protein KIFC3.

M3K14_MOUSE
NC score	0.002046 (rank : 80)	θ value	6.88961 (rank : 64)
Query Neighborhood Hits	81	Target Neighborhood Hits	889	Shared Neighborhood Hits	9
SwissProt Accessions	Q9WUL6	Gene names	Map3k14, Nik
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 14 (EC 2.7.11.25) (NF- kappa beta-inducing kinase) (Serine/threonine-protein kinase NIK).

FIZ1_MOUSE
NC score	0.000194 (rank : 81)	θ value	5.27518 (rank : 54)
Query Neighborhood Hits	81	Target Neighborhood Hits	715	Shared Neighborhood Hits	5
SwissProt Accessions	Q9WTJ4, Q91W14, Q9CTG3	Gene names	Fiz1
Domain Architecture	No domain graphic available
Description	Flt3-interacting zinc finger protein 1.

ARAF_HUMAN
NC score	0.000139 (rank : 82)	θ value	8.99809 (rank : 70)
Query Neighborhood Hits	81	Target Neighborhood Hits	924	Shared Neighborhood Hits	10
SwissProt Accessions	P10398, P07557, Q5H9B3	Gene names	ARAF, ARAF1, PKS, PKS2
Domain Architecture
Description	A-Raf proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1) (A- raf-1) (Proto-oncogene Pks).

ZBT16_HUMAN
NC score	-0.000804 (rank : 83)	θ value	8.99809 (rank : 81)
Query Neighborhood Hits	81	Target Neighborhood Hits	1010	Shared Neighborhood Hits	11
SwissProt Accessions	Q05516, Q8TAL4	Gene names	ZBTB16, PLZF, ZNF145
Domain Architecture
Description	Zinc finger and BTB domain-containing protein 16 (Zinc finger protein PLZF) (Promyelocytic leukemia zinc finger protein) (Zinc finger protein 145).