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Network neighborhood for query Sequence : TNFC_MOUSE

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TNFC_MOUSE
SwissProt Accessions	P41155	Gene names	Ltb, Tnfc, Tnfsf3
Domain Architecture
Description	Lymphotoxin-beta (LT-beta) (Tumor necrosis factor C) (TNF-C) (Tumor necrosis factor ligand superfamily member 3).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

TNFC_MOUSE
θ value	3.51195e-137 (rank : 1)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	31	Target Neighborhood Hits	31	Shared Neighborhood Hits	31
SwissProt Accessions	P41155	Gene names	Ltb, Tnfc, Tnfsf3
Domain Architecture
Description	Lymphotoxin-beta (LT-beta) (Tumor necrosis factor C) (TNF-C) (Tumor necrosis factor ligand superfamily member 3).

TNFC_HUMAN
θ value	7.97034e-73 (rank : 2)	NC score	0.967939 (rank : 2)
Query Neighborhood Hits	31	Target Neighborhood Hits	25	Shared Neighborhood Hits	18
SwissProt Accessions	Q06643, P78370, Q99761	Gene names	LTB, TNFC, TNFSF3
Domain Architecture
Description	Lymphotoxin-beta (LT-beta) (Tumor necrosis factor C) (TNF-C) (Tumor necrosis factor ligand superfamily member 3).

TNF15_HUMAN
θ value	2.36244e-08 (rank : 3)	NC score	0.623360 (rank : 3)
Query Neighborhood Hits	31	Target Neighborhood Hits	16	Shared Neighborhood Hits	16
SwissProt Accessions	O95150	Gene names	TNFSF15, TL1, VEGI
Domain Architecture
Description	Tumor necrosis factor ligand superfamily member 15 (Vascular endothelial cell growth inhibitor) (TNF ligand-related molecule 1).

TNFA_HUMAN
θ value	1.29631e-06 (rank : 4)	NC score	0.591084 (rank : 4)
Query Neighborhood Hits	31	Target Neighborhood Hits	21	Shared Neighborhood Hits	17
SwissProt Accessions	P01375, O43647, Q9P1Q2, Q9UIV3	Gene names	TNF, TNFA, TNFSF2
Domain Architecture
Description	Tumor necrosis factor precursor (TNF-alpha) (Tumor necrosis factor ligand superfamily member 2) (TNF-a) (Cachectin) [Contains: Tumor necrosis factor, membrane form; Tumor necrosis factor, soluble form].

TNF14_MOUSE
θ value	2.21117e-06 (rank : 5)	NC score	0.554481 (rank : 10)
Query Neighborhood Hits	31	Target Neighborhood Hits	21	Shared Neighborhood Hits	16
SwissProt Accessions	Q9QYH9	Gene names	Tnfsf14, Light
Domain Architecture
Description	Tumor necrosis factor ligand superfamily member 14 (CD258 antigen) [Contains: Tumor necrosis factor ligand superfamily member 14, membrane form; Tumor necrosis factor ligand superfamily member 14, soluble form].

TNFL6_HUMAN
θ value	2.88788e-06 (rank : 6)	NC score	0.555890 (rank : 9)
Query Neighborhood Hits	31	Target Neighborhood Hits	50	Shared Neighborhood Hits	17
SwissProt Accessions	P48023, Q9BZP9	Gene names	FASLG, APT1LG1, FASL, TNFSF6
Domain Architecture
Description	Tumor necrosis factor ligand superfamily member 6 (Fas antigen ligand) (Fas ligand) (CD178 antigen) (CD95L protein) (Apoptosis antigen ligand) (APTL) [Contains: Tumor necrosis factor ligand superfamily member 6, membrane form; Tumor necrosis factor ligand superfamily member 6, soluble form].

TNFB_MOUSE
θ value	3.77169e-06 (rank : 7)	NC score	0.579840 (rank : 5)
Query Neighborhood Hits	31	Target Neighborhood Hits	17	Shared Neighborhood Hits	15
SwissProt Accessions	P09225	Gene names	Lta, Tnfb, Tnfsf1
Domain Architecture
Description	Lymphotoxin-alpha precursor (LT-alpha) (TNF-beta) (Tumor necrosis factor ligand superfamily member 1).

TNFA_MOUSE
θ value	8.40245e-06 (rank : 8)	NC score	0.566357 (rank : 6)
Query Neighborhood Hits	31	Target Neighborhood Hits	23	Shared Neighborhood Hits	17
SwissProt Accessions	P06804, O35853, Q62326, Q91VF3	Gene names	Tnf, Tnfa, Tnfsf2
Domain Architecture
Description	Tumor necrosis factor precursor (TNF-alpha) (Tumor necrosis factor ligand superfamily member 2) (TNF-a) (Cachectin) [Contains: Tumor necrosis factor, membrane form; Tumor necrosis factor, soluble form].

TNFB_HUMAN
θ value	8.40245e-06 (rank : 9)	NC score	0.564552 (rank : 7)
Query Neighborhood Hits	31	Target Neighborhood Hits	18	Shared Neighborhood Hits	15
SwissProt Accessions	P01374, Q8N4C3, Q9UKS8	Gene names	LTA, TNFB, TNFSF1
Domain Architecture
Description	Lymphotoxin-alpha precursor (LT-alpha) (TNF-beta) (Tumor necrosis factor ligand superfamily member 1).

TNFL6_MOUSE
θ value	1.43324e-05 (rank : 10)	NC score	0.561629 (rank : 8)
Query Neighborhood Hits	31	Target Neighborhood Hits	46	Shared Neighborhood Hits	17
SwissProt Accessions	P41047, Q61217, Q9R1F2	Gene names	Faslg, Apt1lg1, Fasl, gld, Tnfsf6
Domain Architecture
Description	Tumor necrosis factor ligand superfamily member 6 (Fas antigen ligand) (Fas ligand) (CD178 antigen) (CD95L protein) [Contains: Tumor necrosis factor ligand superfamily member 6, membrane form; Tumor necrosis factor ligand superfamily member 6, soluble form].

TNF11_HUMAN
θ value	5.44631e-05 (rank : 11)	NC score	0.445631 (rank : 13)
Query Neighborhood Hits	31	Target Neighborhood Hits	20	Shared Neighborhood Hits	16
SwissProt Accessions	O14788, O14723, Q96Q17, Q9P2Q3	Gene names	TNFSF11, OPGL, RANKL, TRANCE
Domain Architecture
Description	Tumor necrosis factor ligand superfamily member 11 (Receptor activator of nuclear factor kappa B ligand) (RANKL) (TNF-related activation- induced cytokine) (TRANCE) (Osteoprotegerin ligand) (OPGL) (Osteoclast differentiation factor) (ODF) (CD254 antigen) [Contains: Tumor necrosis factor ligand superfamily member 11, membrane form; Tumor necrosis factor ligand superfamily member 11, soluble form].

TNF11_MOUSE
θ value	0.000121331 (rank : 12)	NC score	0.453154 (rank : 12)
Query Neighborhood Hits	31	Target Neighborhood Hits	17	Shared Neighborhood Hits	17
SwissProt Accessions	O35235, O35306, Q9JJK8, Q9JJK9, Q9R1Y0	Gene names	Tnfsf11, Opgl, Rankl, Trance
Domain Architecture
Description	Tumor necrosis factor ligand superfamily member 11 (Receptor activator of nuclear factor kappa B ligand) (RANKL) (TNF-related activation- induced cytokine) (TRANCE) (Osteoprotegerin ligand) (OPGL) (Osteoclast differentiation factor) (ODF) (CD254 antigen) [Contains: Tumor necrosis factor ligand superfamily member 11, membrane form; Tumor necrosis factor ligand superfamily member 11, soluble form].

TNF14_HUMAN
θ value	0.000121331 (rank : 13)	NC score	0.544447 (rank : 11)
Query Neighborhood Hits	31	Target Neighborhood Hits	19	Shared Neighborhood Hits	17
SwissProt Accessions	O43557, O75476, Q8WVF8, Q96LD2	Gene names	TNFSF14, HVEML, LIGHT
Domain Architecture
Description	Tumor necrosis factor ligand superfamily member 14 (Herpesvirus entry mediator-ligand) (HVEM-L) (CD258 antigen) [Contains: Tumor necrosis factor ligand superfamily member 14, membrane form; Tumor necrosis factor ligand superfamily member 14, soluble form].

CD40L_HUMAN
θ value	0.00175202 (rank : 14)	NC score	0.353348 (rank : 16)
Query Neighborhood Hits	31	Target Neighborhood Hits	19	Shared Neighborhood Hits	14
SwissProt Accessions	P29965	Gene names	CD40LG, CD40L, TNFSF5, TRAP
Domain Architecture
Description	CD40 ligand (CD40-L) (Tumor necrosis factor ligand superfamily member 5) (TNF-related activation protein) (TRAP) (T cell antigen Gp39) (CD154 antigen) [Contains: CD40 ligand, membrane form; CD40 ligand, soluble form].

TNF10_MOUSE
θ value	0.00665767 (rank : 15)	NC score	0.442053 (rank : 14)
Query Neighborhood Hits	31	Target Neighborhood Hits	25	Shared Neighborhood Hits	17
SwissProt Accessions	P50592	Gene names	Tnfsf10, Trail
Domain Architecture
Description	Tumor necrosis factor ligand superfamily member 10 (TNF-related apoptosis-inducing ligand) (Protein TRAIL) (CD253 antigen).

CD40L_MOUSE
θ value	0.0252991 (rank : 16)	NC score	0.302549 (rank : 17)
Query Neighborhood Hits	31	Target Neighborhood Hits	20	Shared Neighborhood Hits	15
SwissProt Accessions	P27548	Gene names	Cd40lg, Cd40l, Tnfsf5
Domain Architecture
Description	CD40 ligand (CD40-L) (Tumor necrosis factor ligand superfamily member 5) (CD154 antigen) (TNF-related activation protein) (TRAP) (T cell antigen Gp39) [Contains: CD40 ligand, membrane form; CD40 ligand, soluble form].

TNF10_HUMAN
θ value	0.0252991 (rank : 17)	NC score	0.413160 (rank : 15)
Query Neighborhood Hits	31	Target Neighborhood Hits	25	Shared Neighborhood Hits	17
SwissProt Accessions	P50591	Gene names	TNFSF10, APO2L, TRAIL
Domain Architecture
Description	Tumor necrosis factor ligand superfamily member 10 (TNF-related apoptosis-inducing ligand) (Protein TRAIL) (Apo-2 ligand) (Apo-2L) (CD253 antigen).

SPHK2_HUMAN
θ value	0.62314 (rank : 18)	NC score	0.045389 (rank : 18)
Query Neighborhood Hits	31	Target Neighborhood Hits	81	Shared Neighborhood Hits	2
SwissProt Accessions	Q9NRA0, Q9BRN1, Q9H0Q2, Q9NWU7	Gene names	SPHK2
Domain Architecture
Description	Sphingosine kinase 2 (EC 2.7.1.-) (SK 2) (SPK 2).

ATN1_HUMAN
θ value	0.813845 (rank : 19)	NC score	0.032999 (rank : 19)
Query Neighborhood Hits	31	Target Neighborhood Hits	676	Shared Neighborhood Hits	3
SwissProt Accessions	P54259, Q99495, Q99621, Q9UEK7	Gene names	ATN1, DRPLA
Domain Architecture
Description	Atrophin-1 (Dentatorubral-pallidoluysian atrophy protein).

ATS19_MOUSE
θ value	1.81305 (rank : 20)	NC score	0.011635 (rank : 30)
Query Neighborhood Hits	31	Target Neighborhood Hits	188	Shared Neighborhood Hits	2
SwissProt Accessions	P59509	Gene names	Adamts19
Domain Architecture
Description	ADAMTS-19 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase with thrombospondin motifs 19) (ADAM-TS 19) (ADAM-TS19).

PSD4_HUMAN
θ value	1.81305 (rank : 21)	NC score	0.025192 (rank : 23)
Query Neighborhood Hits	31	Target Neighborhood Hits	178	Shared Neighborhood Hits	3
SwissProt Accessions	Q8NDX1, O95621, Q4ZG34, Q6GPH8, Q8IYP4	Gene names	PSD4, EFA6B, TIC
Domain Architecture	No domain graphic available
Description	PH and SEC7 domain-containing protein 4 (Pleckstrin homology and SEC7 domain-containing protein 4) (Exchange factor for ADP-ribosylation factor guanine nucleotide factor 6B) (Telomeric of interleukin-1 cluster protein).

S39A4_HUMAN
θ value	3.0926 (rank : 22)	NC score	0.026798 (rank : 22)
Query Neighborhood Hits	31	Target Neighborhood Hits	16	Shared Neighborhood Hits	2
SwissProt Accessions	Q6P5W5, Q7L5S5, Q9H6T8, Q9NXC4	Gene names	SLC39A4, ZIP4
Domain Architecture	No domain graphic available
Description	Zinc transporter ZIP4 precursor (Solute carrier family 39 member 4).

RUNX2_HUMAN
θ value	4.03905 (rank : 23)	NC score	0.028540 (rank : 21)
Query Neighborhood Hits	31	Target Neighborhood Hits	103	Shared Neighborhood Hits	3
SwissProt Accessions	Q13950, O14614, O14615, O95181	Gene names	RUNX2, AML3, CBFA1, OSF2, PEBP2A
Domain Architecture
Description	Runt-related transcription factor 2 (Core-binding factor, alpha 1 subunit) (CBF-alpha 1) (Acute myeloid leukemia 3 protein) (Oncogene AML-3) (Polyomavirus enhancer-binding protein 2 alpha A subunit) (PEBP2-alpha A) (PEA2-alpha A) (SL3-3 enhancer factor 1 alpha A subunit) (SL3/AKV core-binding factor alpha A subunit) (Osteoblast- specific transcription factor 2) (OSF-2).

RUNX2_MOUSE
θ value	4.03905 (rank : 24)	NC score	0.029191 (rank : 20)
Query Neighborhood Hits	31	Target Neighborhood Hits	119	Shared Neighborhood Hits	4
SwissProt Accessions	Q08775, O35183, Q08776, Q9JLN0, Q9QUQ6, Q9QY29, Q9R0U4, Q9Z2J7	Gene names	Runx2, Aml3, Cbfa1, Osf2, Pebp2a
Domain Architecture
Description	Runt-related transcription factor 2 (Core-binding factor, alpha 1 subunit) (CBF-alpha 1) (Acute myeloid leukemia 3 protein) (Oncogene AML-3) (Polyomavirus enhancer-binding protein 2 alpha A subunit) (PEBP2-alpha A) (PEA2-alpha A) (SL3-3 enhancer factor 1 alpha A subunit) (SL3/AKV core-binding factor alpha A subunit) (Osteoblast- specific transcription factor 2) (OSF-2).

I17RA_HUMAN
θ value	5.27518 (rank : 25)	NC score	0.021290 (rank : 24)
Query Neighborhood Hits	31	Target Neighborhood Hits	36	Shared Neighborhood Hits	2
SwissProt Accessions	Q96F46, O43844	Gene names	IL17RA, IL17R
Domain Architecture	No domain graphic available
Description	Interleukin-17 receptor A precursor (IL-17 receptor).

YLPM1_HUMAN
θ value	5.27518 (rank : 26)	NC score	0.018301 (rank : 26)
Query Neighborhood Hits	31	Target Neighborhood Hits	670	Shared Neighborhood Hits	4
SwissProt Accessions	P49750, P49752, Q96I64, Q9P1V7	Gene names	YLPM1, C14orf170, ZAP3
Domain Architecture
Description	YLP motif-containing protein 1 (Nuclear protein ZAP3) (ZAP113).

TENS1_HUMAN
θ value	6.88961 (rank : 27)	NC score	0.014938 (rank : 27)
Query Neighborhood Hits	31	Target Neighborhood Hits	400	Shared Neighborhood Hits	4
SwissProt Accessions	Q9HBL0	Gene names	TNS1, TNS
Domain Architecture	No domain graphic available
Description	Tensin-1.

DGKK_HUMAN
θ value	8.99809 (rank : 28)	NC score	0.008803 (rank : 31)
Query Neighborhood Hits	31	Target Neighborhood Hits	378	Shared Neighborhood Hits	3
SwissProt Accessions	Q5KSL6	Gene names	DGKK
Domain Architecture	No domain graphic available
Description	Diacylglycerol kinase kappa (EC 2.7.1.107) (Diglyceride kinase kappa) (DGK-kappa) (DAG kinase kappa) (142 kDa diacylglycerol kinase).

GORS2_HUMAN
θ value	8.99809 (rank : 29)	NC score	0.013238 (rank : 28)
Query Neighborhood Hits	31	Target Neighborhood Hits	82	Shared Neighborhood Hits	2
SwissProt Accessions	Q9H8Y8, Q96I74, Q96K84, Q9H946, Q9UFW4	Gene names	GORASP2
Domain Architecture	No domain graphic available
Description	Golgi reassembly-stacking protein 2 (GRS2) (Golgi reassembly-stacking protein of 55 kDa) (GRASP55) (p59) (Golgi phosphoprotein 6) (GOLPH6).

MMRN2_HUMAN
θ value	8.99809 (rank : 30)	NC score	0.019157 (rank : 25)
Query Neighborhood Hits	31	Target Neighborhood Hits	400	Shared Neighborhood Hits	3
SwissProt Accessions	Q9H8L6, Q6P2N2	Gene names	MMRN2, EMILIN3
Domain Architecture
Description	Multimerin-2 precursor (EMILIN-3) (Elastin microfibril interface located protein 3) (Elastin microfibril interfacer 3) (EndoGlyx-1 p125/p140 subunit).

PKHG4_HUMAN
θ value	8.99809 (rank : 31)	NC score	0.011825 (rank : 29)
Query Neighborhood Hits	31	Target Neighborhood Hits	200	Shared Neighborhood Hits	2
SwissProt Accessions	Q58EX7, Q4G0J8, Q4H485, Q56A69, Q9H7K4, Q9UFW0	Gene names	PLEKHG4, PRTPHN1
Domain Architecture	No domain graphic available
Description	Puratrophin-1 (Pleckstrin homology domain-containing family G member 4) (Purkinje cell atrophy-associated protein 1).

Hits sorted by NC score

TNFC_MOUSE
NC score	0.999962 (rank : 1)	θ value	3.51195e-137 (rank : 1)
Query Neighborhood Hits	31	Target Neighborhood Hits	31	Shared Neighborhood Hits	31
SwissProt Accessions	P41155	Gene names	Ltb, Tnfc, Tnfsf3
Domain Architecture
Description	Lymphotoxin-beta (LT-beta) (Tumor necrosis factor C) (TNF-C) (Tumor necrosis factor ligand superfamily member 3).

TNFC_HUMAN
NC score	0.967939 (rank : 2)	θ value	7.97034e-73 (rank : 2)
Query Neighborhood Hits	31	Target Neighborhood Hits	25	Shared Neighborhood Hits	18
SwissProt Accessions	Q06643, P78370, Q99761	Gene names	LTB, TNFC, TNFSF3
Domain Architecture
Description	Lymphotoxin-beta (LT-beta) (Tumor necrosis factor C) (TNF-C) (Tumor necrosis factor ligand superfamily member 3).

TNF15_HUMAN
NC score	0.623360 (rank : 3)	θ value	2.36244e-08 (rank : 3)
Query Neighborhood Hits	31	Target Neighborhood Hits	16	Shared Neighborhood Hits	16
SwissProt Accessions	O95150	Gene names	TNFSF15, TL1, VEGI
Domain Architecture
Description	Tumor necrosis factor ligand superfamily member 15 (Vascular endothelial cell growth inhibitor) (TNF ligand-related molecule 1).

TNFA_HUMAN
NC score	0.591084 (rank : 4)	θ value	1.29631e-06 (rank : 4)
Query Neighborhood Hits	31	Target Neighborhood Hits	21	Shared Neighborhood Hits	17
SwissProt Accessions	P01375, O43647, Q9P1Q2, Q9UIV3	Gene names	TNF, TNFA, TNFSF2
Domain Architecture
Description	Tumor necrosis factor precursor (TNF-alpha) (Tumor necrosis factor ligand superfamily member 2) (TNF-a) (Cachectin) [Contains: Tumor necrosis factor, membrane form; Tumor necrosis factor, soluble form].

TNFB_MOUSE
NC score	0.579840 (rank : 5)	θ value	3.77169e-06 (rank : 7)
Query Neighborhood Hits	31	Target Neighborhood Hits	17	Shared Neighborhood Hits	15
SwissProt Accessions	P09225	Gene names	Lta, Tnfb, Tnfsf1
Domain Architecture
Description	Lymphotoxin-alpha precursor (LT-alpha) (TNF-beta) (Tumor necrosis factor ligand superfamily member 1).

TNFA_MOUSE
NC score	0.566357 (rank : 6)	θ value	8.40245e-06 (rank : 8)
Query Neighborhood Hits	31	Target Neighborhood Hits	23	Shared Neighborhood Hits	17
SwissProt Accessions	P06804, O35853, Q62326, Q91VF3	Gene names	Tnf, Tnfa, Tnfsf2
Domain Architecture
Description	Tumor necrosis factor precursor (TNF-alpha) (Tumor necrosis factor ligand superfamily member 2) (TNF-a) (Cachectin) [Contains: Tumor necrosis factor, membrane form; Tumor necrosis factor, soluble form].

TNFB_HUMAN
NC score	0.564552 (rank : 7)	θ value	8.40245e-06 (rank : 9)
Query Neighborhood Hits	31	Target Neighborhood Hits	18	Shared Neighborhood Hits	15
SwissProt Accessions	P01374, Q8N4C3, Q9UKS8	Gene names	LTA, TNFB, TNFSF1
Domain Architecture
Description	Lymphotoxin-alpha precursor (LT-alpha) (TNF-beta) (Tumor necrosis factor ligand superfamily member 1).

TNFL6_MOUSE
NC score	0.561629 (rank : 8)	θ value	1.43324e-05 (rank : 10)
Query Neighborhood Hits	31	Target Neighborhood Hits	46	Shared Neighborhood Hits	17
SwissProt Accessions	P41047, Q61217, Q9R1F2	Gene names	Faslg, Apt1lg1, Fasl, gld, Tnfsf6
Domain Architecture
Description	Tumor necrosis factor ligand superfamily member 6 (Fas antigen ligand) (Fas ligand) (CD178 antigen) (CD95L protein) [Contains: Tumor necrosis factor ligand superfamily member 6, membrane form; Tumor necrosis factor ligand superfamily member 6, soluble form].

TNFL6_HUMAN
NC score	0.555890 (rank : 9)	θ value	2.88788e-06 (rank : 6)
Query Neighborhood Hits	31	Target Neighborhood Hits	50	Shared Neighborhood Hits	17
SwissProt Accessions	P48023, Q9BZP9	Gene names	FASLG, APT1LG1, FASL, TNFSF6
Domain Architecture
Description	Tumor necrosis factor ligand superfamily member 6 (Fas antigen ligand) (Fas ligand) (CD178 antigen) (CD95L protein) (Apoptosis antigen ligand) (APTL) [Contains: Tumor necrosis factor ligand superfamily member 6, membrane form; Tumor necrosis factor ligand superfamily member 6, soluble form].

TNF14_MOUSE
NC score	0.554481 (rank : 10)	θ value	2.21117e-06 (rank : 5)
Query Neighborhood Hits	31	Target Neighborhood Hits	21	Shared Neighborhood Hits	16
SwissProt Accessions	Q9QYH9	Gene names	Tnfsf14, Light
Domain Architecture
Description	Tumor necrosis factor ligand superfamily member 14 (CD258 antigen) [Contains: Tumor necrosis factor ligand superfamily member 14, membrane form; Tumor necrosis factor ligand superfamily member 14, soluble form].

TNF14_HUMAN
NC score	0.544447 (rank : 11)	θ value	0.000121331 (rank : 13)
Query Neighborhood Hits	31	Target Neighborhood Hits	19	Shared Neighborhood Hits	17
SwissProt Accessions	O43557, O75476, Q8WVF8, Q96LD2	Gene names	TNFSF14, HVEML, LIGHT
Domain Architecture
Description	Tumor necrosis factor ligand superfamily member 14 (Herpesvirus entry mediator-ligand) (HVEM-L) (CD258 antigen) [Contains: Tumor necrosis factor ligand superfamily member 14, membrane form; Tumor necrosis factor ligand superfamily member 14, soluble form].

TNF11_MOUSE
NC score	0.453154 (rank : 12)	θ value	0.000121331 (rank : 12)
Query Neighborhood Hits	31	Target Neighborhood Hits	17	Shared Neighborhood Hits	17
SwissProt Accessions	O35235, O35306, Q9JJK8, Q9JJK9, Q9R1Y0	Gene names	Tnfsf11, Opgl, Rankl, Trance
Domain Architecture
Description	Tumor necrosis factor ligand superfamily member 11 (Receptor activator of nuclear factor kappa B ligand) (RANKL) (TNF-related activation- induced cytokine) (TRANCE) (Osteoprotegerin ligand) (OPGL) (Osteoclast differentiation factor) (ODF) (CD254 antigen) [Contains: Tumor necrosis factor ligand superfamily member 11, membrane form; Tumor necrosis factor ligand superfamily member 11, soluble form].

TNF11_HUMAN
NC score	0.445631 (rank : 13)	θ value	5.44631e-05 (rank : 11)
Query Neighborhood Hits	31	Target Neighborhood Hits	20	Shared Neighborhood Hits	16
SwissProt Accessions	O14788, O14723, Q96Q17, Q9P2Q3	Gene names	TNFSF11, OPGL, RANKL, TRANCE
Domain Architecture
Description	Tumor necrosis factor ligand superfamily member 11 (Receptor activator of nuclear factor kappa B ligand) (RANKL) (TNF-related activation- induced cytokine) (TRANCE) (Osteoprotegerin ligand) (OPGL) (Osteoclast differentiation factor) (ODF) (CD254 antigen) [Contains: Tumor necrosis factor ligand superfamily member 11, membrane form; Tumor necrosis factor ligand superfamily member 11, soluble form].

TNF10_MOUSE
NC score	0.442053 (rank : 14)	θ value	0.00665767 (rank : 15)
Query Neighborhood Hits	31	Target Neighborhood Hits	25	Shared Neighborhood Hits	17
SwissProt Accessions	P50592	Gene names	Tnfsf10, Trail
Domain Architecture
Description	Tumor necrosis factor ligand superfamily member 10 (TNF-related apoptosis-inducing ligand) (Protein TRAIL) (CD253 antigen).

TNF10_HUMAN
NC score	0.413160 (rank : 15)	θ value	0.0252991 (rank : 17)
Query Neighborhood Hits	31	Target Neighborhood Hits	25	Shared Neighborhood Hits	17
SwissProt Accessions	P50591	Gene names	TNFSF10, APO2L, TRAIL
Domain Architecture
Description	Tumor necrosis factor ligand superfamily member 10 (TNF-related apoptosis-inducing ligand) (Protein TRAIL) (Apo-2 ligand) (Apo-2L) (CD253 antigen).

CD40L_HUMAN
NC score	0.353348 (rank : 16)	θ value	0.00175202 (rank : 14)
Query Neighborhood Hits	31	Target Neighborhood Hits	19	Shared Neighborhood Hits	14
SwissProt Accessions	P29965	Gene names	CD40LG, CD40L, TNFSF5, TRAP
Domain Architecture
Description	CD40 ligand (CD40-L) (Tumor necrosis factor ligand superfamily member 5) (TNF-related activation protein) (TRAP) (T cell antigen Gp39) (CD154 antigen) [Contains: CD40 ligand, membrane form; CD40 ligand, soluble form].

CD40L_MOUSE
NC score	0.302549 (rank : 17)	θ value	0.0252991 (rank : 16)
Query Neighborhood Hits	31	Target Neighborhood Hits	20	Shared Neighborhood Hits	15
SwissProt Accessions	P27548	Gene names	Cd40lg, Cd40l, Tnfsf5
Domain Architecture
Description	CD40 ligand (CD40-L) (Tumor necrosis factor ligand superfamily member 5) (CD154 antigen) (TNF-related activation protein) (TRAP) (T cell antigen Gp39) [Contains: CD40 ligand, membrane form; CD40 ligand, soluble form].

SPHK2_HUMAN
NC score	0.045389 (rank : 18)	θ value	0.62314 (rank : 18)
Query Neighborhood Hits	31	Target Neighborhood Hits	81	Shared Neighborhood Hits	2
SwissProt Accessions	Q9NRA0, Q9BRN1, Q9H0Q2, Q9NWU7	Gene names	SPHK2
Domain Architecture
Description	Sphingosine kinase 2 (EC 2.7.1.-) (SK 2) (SPK 2).

ATN1_HUMAN
NC score	0.032999 (rank : 19)	θ value	0.813845 (rank : 19)
Query Neighborhood Hits	31	Target Neighborhood Hits	676	Shared Neighborhood Hits	3
SwissProt Accessions	P54259, Q99495, Q99621, Q9UEK7	Gene names	ATN1, DRPLA
Domain Architecture
Description	Atrophin-1 (Dentatorubral-pallidoluysian atrophy protein).

RUNX2_MOUSE
NC score	0.029191 (rank : 20)	θ value	4.03905 (rank : 24)
Query Neighborhood Hits	31	Target Neighborhood Hits	119	Shared Neighborhood Hits	4
SwissProt Accessions	Q08775, O35183, Q08776, Q9JLN0, Q9QUQ6, Q9QY29, Q9R0U4, Q9Z2J7	Gene names	Runx2, Aml3, Cbfa1, Osf2, Pebp2a
Domain Architecture
Description	Runt-related transcription factor 2 (Core-binding factor, alpha 1 subunit) (CBF-alpha 1) (Acute myeloid leukemia 3 protein) (Oncogene AML-3) (Polyomavirus enhancer-binding protein 2 alpha A subunit) (PEBP2-alpha A) (PEA2-alpha A) (SL3-3 enhancer factor 1 alpha A subunit) (SL3/AKV core-binding factor alpha A subunit) (Osteoblast- specific transcription factor 2) (OSF-2).

RUNX2_HUMAN
NC score	0.028540 (rank : 21)	θ value	4.03905 (rank : 23)
Query Neighborhood Hits	31	Target Neighborhood Hits	103	Shared Neighborhood Hits	3
SwissProt Accessions	Q13950, O14614, O14615, O95181	Gene names	RUNX2, AML3, CBFA1, OSF2, PEBP2A
Domain Architecture
Description	Runt-related transcription factor 2 (Core-binding factor, alpha 1 subunit) (CBF-alpha 1) (Acute myeloid leukemia 3 protein) (Oncogene AML-3) (Polyomavirus enhancer-binding protein 2 alpha A subunit) (PEBP2-alpha A) (PEA2-alpha A) (SL3-3 enhancer factor 1 alpha A subunit) (SL3/AKV core-binding factor alpha A subunit) (Osteoblast- specific transcription factor 2) (OSF-2).

S39A4_HUMAN
NC score	0.026798 (rank : 22)	θ value	3.0926 (rank : 22)
Query Neighborhood Hits	31	Target Neighborhood Hits	16	Shared Neighborhood Hits	2
SwissProt Accessions	Q6P5W5, Q7L5S5, Q9H6T8, Q9NXC4	Gene names	SLC39A4, ZIP4
Domain Architecture	No domain graphic available
Description	Zinc transporter ZIP4 precursor (Solute carrier family 39 member 4).

PSD4_HUMAN
NC score	0.025192 (rank : 23)	θ value	1.81305 (rank : 21)
Query Neighborhood Hits	31	Target Neighborhood Hits	178	Shared Neighborhood Hits	3
SwissProt Accessions	Q8NDX1, O95621, Q4ZG34, Q6GPH8, Q8IYP4	Gene names	PSD4, EFA6B, TIC
Domain Architecture	No domain graphic available
Description	PH and SEC7 domain-containing protein 4 (Pleckstrin homology and SEC7 domain-containing protein 4) (Exchange factor for ADP-ribosylation factor guanine nucleotide factor 6B) (Telomeric of interleukin-1 cluster protein).

I17RA_HUMAN
NC score	0.021290 (rank : 24)	θ value	5.27518 (rank : 25)
Query Neighborhood Hits	31	Target Neighborhood Hits	36	Shared Neighborhood Hits	2
SwissProt Accessions	Q96F46, O43844	Gene names	IL17RA, IL17R
Domain Architecture	No domain graphic available
Description	Interleukin-17 receptor A precursor (IL-17 receptor).

MMRN2_HUMAN
NC score	0.019157 (rank : 25)	θ value	8.99809 (rank : 30)
Query Neighborhood Hits	31	Target Neighborhood Hits	400	Shared Neighborhood Hits	3
SwissProt Accessions	Q9H8L6, Q6P2N2	Gene names	MMRN2, EMILIN3
Domain Architecture
Description	Multimerin-2 precursor (EMILIN-3) (Elastin microfibril interface located protein 3) (Elastin microfibril interfacer 3) (EndoGlyx-1 p125/p140 subunit).

YLPM1_HUMAN
NC score	0.018301 (rank : 26)	θ value	5.27518 (rank : 26)
Query Neighborhood Hits	31	Target Neighborhood Hits	670	Shared Neighborhood Hits	4
SwissProt Accessions	P49750, P49752, Q96I64, Q9P1V7	Gene names	YLPM1, C14orf170, ZAP3
Domain Architecture
Description	YLP motif-containing protein 1 (Nuclear protein ZAP3) (ZAP113).

TENS1_HUMAN
NC score	0.014938 (rank : 27)	θ value	6.88961 (rank : 27)
Query Neighborhood Hits	31	Target Neighborhood Hits	400	Shared Neighborhood Hits	4
SwissProt Accessions	Q9HBL0	Gene names	TNS1, TNS
Domain Architecture	No domain graphic available
Description	Tensin-1.

GORS2_HUMAN
NC score	0.013238 (rank : 28)	θ value	8.99809 (rank : 29)
Query Neighborhood Hits	31	Target Neighborhood Hits	82	Shared Neighborhood Hits	2
SwissProt Accessions	Q9H8Y8, Q96I74, Q96K84, Q9H946, Q9UFW4	Gene names	GORASP2
Domain Architecture	No domain graphic available
Description	Golgi reassembly-stacking protein 2 (GRS2) (Golgi reassembly-stacking protein of 55 kDa) (GRASP55) (p59) (Golgi phosphoprotein 6) (GOLPH6).

PKHG4_HUMAN
NC score	0.011825 (rank : 29)	θ value	8.99809 (rank : 31)
Query Neighborhood Hits	31	Target Neighborhood Hits	200	Shared Neighborhood Hits	2
SwissProt Accessions	Q58EX7, Q4G0J8, Q4H485, Q56A69, Q9H7K4, Q9UFW0	Gene names	PLEKHG4, PRTPHN1
Domain Architecture	No domain graphic available
Description	Puratrophin-1 (Pleckstrin homology domain-containing family G member 4) (Purkinje cell atrophy-associated protein 1).

ATS19_MOUSE
NC score	0.011635 (rank : 30)	θ value	1.81305 (rank : 20)
Query Neighborhood Hits	31	Target Neighborhood Hits	188	Shared Neighborhood Hits	2
SwissProt Accessions	P59509	Gene names	Adamts19
Domain Architecture
Description	ADAMTS-19 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase with thrombospondin motifs 19) (ADAM-TS 19) (ADAM-TS19).

DGKK_HUMAN
NC score	0.008803 (rank : 31)	θ value	8.99809 (rank : 28)
Query Neighborhood Hits	31	Target Neighborhood Hits	378	Shared Neighborhood Hits	3
SwissProt Accessions	Q5KSL6	Gene names	DGKK
Domain Architecture	No domain graphic available
Description	Diacylglycerol kinase kappa (EC 2.7.1.107) (Diglyceride kinase kappa) (DGK-kappa) (DAG kinase kappa) (142 kDa diacylglycerol kinase).