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Network neighborhood for query Sequence : CD40L_HUMAN

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CD40L_HUMAN
SwissProt Accessions	P29965	Gene names	CD40LG, CD40L, TNFSF5, TRAP
Domain Architecture
Description	CD40 ligand (CD40-L) (Tumor necrosis factor ligand superfamily member 5) (TNF-related activation protein) (TRAP) (T cell antigen Gp39) (CD154 antigen) [Contains: CD40 ligand, membrane form; CD40 ligand, soluble form].
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

CD40L_HUMAN
θ value	4.88915e-147 (rank : 1)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	19	Target Neighborhood Hits	19	Shared Neighborhood Hits	19
SwissProt Accessions	P29965	Gene names	CD40LG, CD40L, TNFSF5, TRAP
Domain Architecture
Description	CD40 ligand (CD40-L) (Tumor necrosis factor ligand superfamily member 5) (TNF-related activation protein) (TRAP) (T cell antigen Gp39) (CD154 antigen) [Contains: CD40 ligand, membrane form; CD40 ligand, soluble form].

CD40L_MOUSE
θ value	1.13764e-111 (rank : 2)	NC score	0.986453 (rank : 2)
Query Neighborhood Hits	19	Target Neighborhood Hits	20	Shared Neighborhood Hits	14
SwissProt Accessions	P27548	Gene names	Cd40lg, Cd40l, Tnfsf5
Domain Architecture
Description	CD40 ligand (CD40-L) (Tumor necrosis factor ligand superfamily member 5) (CD154 antigen) (TNF-related activation protein) (TRAP) (T cell antigen Gp39) [Contains: CD40 ligand, membrane form; CD40 ligand, soluble form].

TNF11_MOUSE
θ value	4.0297e-08 (rank : 3)	NC score	0.492106 (rank : 3)
Query Neighborhood Hits	19	Target Neighborhood Hits	17	Shared Neighborhood Hits	14
SwissProt Accessions	O35235, O35306, Q9JJK8, Q9JJK9, Q9R1Y0	Gene names	Tnfsf11, Opgl, Rankl, Trance
Domain Architecture
Description	Tumor necrosis factor ligand superfamily member 11 (Receptor activator of nuclear factor kappa B ligand) (RANKL) (TNF-related activation- induced cytokine) (TRANCE) (Osteoprotegerin ligand) (OPGL) (Osteoclast differentiation factor) (ODF) (CD254 antigen) [Contains: Tumor necrosis factor ligand superfamily member 11, membrane form; Tumor necrosis factor ligand superfamily member 11, soluble form].

TNF11_HUMAN
θ value	1.69304e-06 (rank : 4)	NC score	0.450460 (rank : 5)
Query Neighborhood Hits	19	Target Neighborhood Hits	20	Shared Neighborhood Hits	13
SwissProt Accessions	O14788, O14723, Q96Q17, Q9P2Q3	Gene names	TNFSF11, OPGL, RANKL, TRANCE
Domain Architecture
Description	Tumor necrosis factor ligand superfamily member 11 (Receptor activator of nuclear factor kappa B ligand) (RANKL) (TNF-related activation- induced cytokine) (TRANCE) (Osteoprotegerin ligand) (OPGL) (Osteoclast differentiation factor) (ODF) (CD254 antigen) [Contains: Tumor necrosis factor ligand superfamily member 11, membrane form; Tumor necrosis factor ligand superfamily member 11, soluble form].

TNF10_HUMAN
θ value	1.87187e-05 (rank : 5)	NC score	0.449111 (rank : 6)
Query Neighborhood Hits	19	Target Neighborhood Hits	25	Shared Neighborhood Hits	15
SwissProt Accessions	P50591	Gene names	TNFSF10, APO2L, TRAIL
Domain Architecture
Description	Tumor necrosis factor ligand superfamily member 10 (TNF-related apoptosis-inducing ligand) (Protein TRAIL) (Apo-2 ligand) (Apo-2L) (CD253 antigen).

TNFA_HUMAN
θ value	7.1131e-05 (rank : 6)	NC score	0.378293 (rank : 9)
Query Neighborhood Hits	19	Target Neighborhood Hits	21	Shared Neighborhood Hits	14
SwissProt Accessions	P01375, O43647, Q9P1Q2, Q9UIV3	Gene names	TNF, TNFA, TNFSF2
Domain Architecture
Description	Tumor necrosis factor precursor (TNF-alpha) (Tumor necrosis factor ligand superfamily member 2) (TNF-a) (Cachectin) [Contains: Tumor necrosis factor, membrane form; Tumor necrosis factor, soluble form].

TNF10_MOUSE
θ value	9.29e-05 (rank : 7)	NC score	0.464947 (rank : 4)
Query Neighborhood Hits	19	Target Neighborhood Hits	25	Shared Neighborhood Hits	15
SwissProt Accessions	P50592	Gene names	Tnfsf10, Trail
Domain Architecture
Description	Tumor necrosis factor ligand superfamily member 10 (TNF-related apoptosis-inducing ligand) (Protein TRAIL) (CD253 antigen).

TNFL6_HUMAN
θ value	0.000461057 (rank : 8)	NC score	0.385005 (rank : 8)
Query Neighborhood Hits	19	Target Neighborhood Hits	50	Shared Neighborhood Hits	14
SwissProt Accessions	P48023, Q9BZP9	Gene names	FASLG, APT1LG1, FASL, TNFSF6
Domain Architecture
Description	Tumor necrosis factor ligand superfamily member 6 (Fas antigen ligand) (Fas ligand) (CD178 antigen) (CD95L protein) (Apoptosis antigen ligand) (APTL) [Contains: Tumor necrosis factor ligand superfamily member 6, membrane form; Tumor necrosis factor ligand superfamily member 6, soluble form].

TNFL6_MOUSE
θ value	0.00102713 (rank : 9)	NC score	0.390528 (rank : 7)
Query Neighborhood Hits	19	Target Neighborhood Hits	46	Shared Neighborhood Hits	14
SwissProt Accessions	P41047, Q61217, Q9R1F2	Gene names	Faslg, Apt1lg1, Fasl, gld, Tnfsf6
Domain Architecture
Description	Tumor necrosis factor ligand superfamily member 6 (Fas antigen ligand) (Fas ligand) (CD178 antigen) (CD95L protein) [Contains: Tumor necrosis factor ligand superfamily member 6, membrane form; Tumor necrosis factor ligand superfamily member 6, soluble form].

TNFC_MOUSE
θ value	0.00175202 (rank : 10)	NC score	0.353348 (rank : 10)
Query Neighborhood Hits	19	Target Neighborhood Hits	31	Shared Neighborhood Hits	14
SwissProt Accessions	P41155	Gene names	Ltb, Tnfc, Tnfsf3
Domain Architecture
Description	Lymphotoxin-beta (LT-beta) (Tumor necrosis factor C) (TNF-C) (Tumor necrosis factor ligand superfamily member 3).

TNFC_HUMAN
θ value	0.00228821 (rank : 11)	NC score	0.334857 (rank : 12)
Query Neighborhood Hits	19	Target Neighborhood Hits	25	Shared Neighborhood Hits	14
SwissProt Accessions	Q06643, P78370, Q99761	Gene names	LTB, TNFC, TNFSF3
Domain Architecture
Description	Lymphotoxin-beta (LT-beta) (Tumor necrosis factor C) (TNF-C) (Tumor necrosis factor ligand superfamily member 3).

TNFA_MOUSE
θ value	0.0148317 (rank : 12)	NC score	0.322300 (rank : 13)
Query Neighborhood Hits	19	Target Neighborhood Hits	23	Shared Neighborhood Hits	14
SwissProt Accessions	P06804, O35853, Q62326, Q91VF3	Gene names	Tnf, Tnfa, Tnfsf2
Domain Architecture
Description	Tumor necrosis factor precursor (TNF-alpha) (Tumor necrosis factor ligand superfamily member 2) (TNF-a) (Cachectin) [Contains: Tumor necrosis factor, membrane form; Tumor necrosis factor, soluble form].

TNF15_HUMAN
θ value	0.0563607 (rank : 13)	NC score	0.337083 (rank : 11)
Query Neighborhood Hits	19	Target Neighborhood Hits	16	Shared Neighborhood Hits	13
SwissProt Accessions	O95150	Gene names	TNFSF15, TL1, VEGI
Domain Architecture
Description	Tumor necrosis factor ligand superfamily member 15 (Vascular endothelial cell growth inhibitor) (TNF ligand-related molecule 1).

TNF12_MOUSE
θ value	0.62314 (rank : 14)	NC score	0.081008 (rank : 18)
Query Neighborhood Hits	19	Target Neighborhood Hits	5	Shared Neighborhood Hits	3
SwissProt Accessions	O54907, Q9CTP2	Gene names	Tnfsf12
Domain Architecture
Description	Tumor necrosis factor ligand superfamily member 12 (TNF-related weak inducer of apoptosis) (TWEAK) [Contains: Tumor necrosis factor ligand superfamily member 12, membrane form; Tumor necrosis factor ligand superfamily member 12, secreted form].

TNFL7_HUMAN
θ value	0.813845 (rank : 15)	NC score	0.065888 (rank : 20)
Query Neighborhood Hits	19	Target Neighborhood Hits	5	Shared Neighborhood Hits	2
SwissProt Accessions	P32970, Q96J57	Gene names	TNFSF7, CD27L, CD27LG, CD70
Domain Architecture
Description	Tumor necrosis factor ligand superfamily member 7 (CD27 ligand) (CD27- L) (CD70 antigen).

TNF14_HUMAN
θ value	1.06291 (rank : 16)	NC score	0.251151 (rank : 14)
Query Neighborhood Hits	19	Target Neighborhood Hits	19	Shared Neighborhood Hits	14
SwissProt Accessions	O43557, O75476, Q8WVF8, Q96LD2	Gene names	TNFSF14, HVEML, LIGHT
Domain Architecture
Description	Tumor necrosis factor ligand superfamily member 14 (Herpesvirus entry mediator-ligand) (HVEM-L) (CD258 antigen) [Contains: Tumor necrosis factor ligand superfamily member 14, membrane form; Tumor necrosis factor ligand superfamily member 14, soluble form].

TNF12_HUMAN
θ value	3.0926 (rank : 17)	NC score	0.077051 (rank : 19)
Query Neighborhood Hits	19	Target Neighborhood Hits	9	Shared Neighborhood Hits	5
SwissProt Accessions	O43508, Q8WUZ7	Gene names	TNFSF12, APO3L, DR3LG
Domain Architecture
Description	Tumor necrosis factor ligand superfamily member 12 (TNF-related weak inducer of apoptosis) (TWEAK) (APO3 ligand) [Contains: Tumor necrosis factor ligand superfamily member 12, membrane form; Tumor necrosis factor ligand superfamily member 12, secreted form].

TNF14_MOUSE
θ value	θ > 10 (rank : 20)	NC score	0.222157 (rank : 15)
Query Neighborhood Hits	19	Target Neighborhood Hits	21	Shared Neighborhood Hits	13
SwissProt Accessions	Q9QYH9	Gene names	Tnfsf14, Light
Domain Architecture
Description	Tumor necrosis factor ligand superfamily member 14 (CD258 antigen) [Contains: Tumor necrosis factor ligand superfamily member 14, membrane form; Tumor necrosis factor ligand superfamily member 14, soluble form].

TNFB_HUMAN
θ value	θ > 10 (rank : 21)	NC score	0.186151 (rank : 17)
Query Neighborhood Hits	19	Target Neighborhood Hits	18	Shared Neighborhood Hits	12
SwissProt Accessions	P01374, Q8N4C3, Q9UKS8	Gene names	LTA, TNFB, TNFSF1
Domain Architecture
Description	Lymphotoxin-alpha precursor (LT-alpha) (TNF-beta) (Tumor necrosis factor ligand superfamily member 1).

TNFB_MOUSE
θ value	θ > 10 (rank : 22)	NC score	0.190103 (rank : 16)
Query Neighborhood Hits	19	Target Neighborhood Hits	17	Shared Neighborhood Hits	12
SwissProt Accessions	P09225	Gene names	Lta, Tnfb, Tnfsf1
Domain Architecture
Description	Lymphotoxin-alpha precursor (LT-alpha) (TNF-beta) (Tumor necrosis factor ligand superfamily member 1).

Hits sorted by NC score

CD40L_HUMAN
NC score	0.999962 (rank : 1)	θ value	4.88915e-147 (rank : 1)
Query Neighborhood Hits	19	Target Neighborhood Hits	19	Shared Neighborhood Hits	19
SwissProt Accessions	P29965	Gene names	CD40LG, CD40L, TNFSF5, TRAP
Domain Architecture
Description	CD40 ligand (CD40-L) (Tumor necrosis factor ligand superfamily member 5) (TNF-related activation protein) (TRAP) (T cell antigen Gp39) (CD154 antigen) [Contains: CD40 ligand, membrane form; CD40 ligand, soluble form].

CD40L_MOUSE
NC score	0.986453 (rank : 2)	θ value	1.13764e-111 (rank : 2)
Query Neighborhood Hits	19	Target Neighborhood Hits	20	Shared Neighborhood Hits	14
SwissProt Accessions	P27548	Gene names	Cd40lg, Cd40l, Tnfsf5
Domain Architecture
Description	CD40 ligand (CD40-L) (Tumor necrosis factor ligand superfamily member 5) (CD154 antigen) (TNF-related activation protein) (TRAP) (T cell antigen Gp39) [Contains: CD40 ligand, membrane form; CD40 ligand, soluble form].

TNF11_MOUSE
NC score	0.492106 (rank : 3)	θ value	4.0297e-08 (rank : 3)
Query Neighborhood Hits	19	Target Neighborhood Hits	17	Shared Neighborhood Hits	14
SwissProt Accessions	O35235, O35306, Q9JJK8, Q9JJK9, Q9R1Y0	Gene names	Tnfsf11, Opgl, Rankl, Trance
Domain Architecture
Description	Tumor necrosis factor ligand superfamily member 11 (Receptor activator of nuclear factor kappa B ligand) (RANKL) (TNF-related activation- induced cytokine) (TRANCE) (Osteoprotegerin ligand) (OPGL) (Osteoclast differentiation factor) (ODF) (CD254 antigen) [Contains: Tumor necrosis factor ligand superfamily member 11, membrane form; Tumor necrosis factor ligand superfamily member 11, soluble form].

TNF10_MOUSE
NC score	0.464947 (rank : 4)	θ value	9.29e-05 (rank : 7)
Query Neighborhood Hits	19	Target Neighborhood Hits	25	Shared Neighborhood Hits	15
SwissProt Accessions	P50592	Gene names	Tnfsf10, Trail
Domain Architecture
Description	Tumor necrosis factor ligand superfamily member 10 (TNF-related apoptosis-inducing ligand) (Protein TRAIL) (CD253 antigen).

TNF11_HUMAN
NC score	0.450460 (rank : 5)	θ value	1.69304e-06 (rank : 4)
Query Neighborhood Hits	19	Target Neighborhood Hits	20	Shared Neighborhood Hits	13
SwissProt Accessions	O14788, O14723, Q96Q17, Q9P2Q3	Gene names	TNFSF11, OPGL, RANKL, TRANCE
Domain Architecture
Description	Tumor necrosis factor ligand superfamily member 11 (Receptor activator of nuclear factor kappa B ligand) (RANKL) (TNF-related activation- induced cytokine) (TRANCE) (Osteoprotegerin ligand) (OPGL) (Osteoclast differentiation factor) (ODF) (CD254 antigen) [Contains: Tumor necrosis factor ligand superfamily member 11, membrane form; Tumor necrosis factor ligand superfamily member 11, soluble form].

TNF10_HUMAN
NC score	0.449111 (rank : 6)	θ value	1.87187e-05 (rank : 5)
Query Neighborhood Hits	19	Target Neighborhood Hits	25	Shared Neighborhood Hits	15
SwissProt Accessions	P50591	Gene names	TNFSF10, APO2L, TRAIL
Domain Architecture
Description	Tumor necrosis factor ligand superfamily member 10 (TNF-related apoptosis-inducing ligand) (Protein TRAIL) (Apo-2 ligand) (Apo-2L) (CD253 antigen).

TNFL6_MOUSE
NC score	0.390528 (rank : 7)	θ value	0.00102713 (rank : 9)
Query Neighborhood Hits	19	Target Neighborhood Hits	46	Shared Neighborhood Hits	14
SwissProt Accessions	P41047, Q61217, Q9R1F2	Gene names	Faslg, Apt1lg1, Fasl, gld, Tnfsf6
Domain Architecture
Description	Tumor necrosis factor ligand superfamily member 6 (Fas antigen ligand) (Fas ligand) (CD178 antigen) (CD95L protein) [Contains: Tumor necrosis factor ligand superfamily member 6, membrane form; Tumor necrosis factor ligand superfamily member 6, soluble form].

TNFL6_HUMAN
NC score	0.385005 (rank : 8)	θ value	0.000461057 (rank : 8)
Query Neighborhood Hits	19	Target Neighborhood Hits	50	Shared Neighborhood Hits	14
SwissProt Accessions	P48023, Q9BZP9	Gene names	FASLG, APT1LG1, FASL, TNFSF6
Domain Architecture
Description	Tumor necrosis factor ligand superfamily member 6 (Fas antigen ligand) (Fas ligand) (CD178 antigen) (CD95L protein) (Apoptosis antigen ligand) (APTL) [Contains: Tumor necrosis factor ligand superfamily member 6, membrane form; Tumor necrosis factor ligand superfamily member 6, soluble form].

TNFA_HUMAN
NC score	0.378293 (rank : 9)	θ value	7.1131e-05 (rank : 6)
Query Neighborhood Hits	19	Target Neighborhood Hits	21	Shared Neighborhood Hits	14
SwissProt Accessions	P01375, O43647, Q9P1Q2, Q9UIV3	Gene names	TNF, TNFA, TNFSF2
Domain Architecture
Description	Tumor necrosis factor precursor (TNF-alpha) (Tumor necrosis factor ligand superfamily member 2) (TNF-a) (Cachectin) [Contains: Tumor necrosis factor, membrane form; Tumor necrosis factor, soluble form].

TNFC_MOUSE
NC score	0.353348 (rank : 10)	θ value	0.00175202 (rank : 10)
Query Neighborhood Hits	19	Target Neighborhood Hits	31	Shared Neighborhood Hits	14
SwissProt Accessions	P41155	Gene names	Ltb, Tnfc, Tnfsf3
Domain Architecture
Description	Lymphotoxin-beta (LT-beta) (Tumor necrosis factor C) (TNF-C) (Tumor necrosis factor ligand superfamily member 3).

TNF15_HUMAN
NC score	0.337083 (rank : 11)	θ value	0.0563607 (rank : 13)
Query Neighborhood Hits	19	Target Neighborhood Hits	16	Shared Neighborhood Hits	13
SwissProt Accessions	O95150	Gene names	TNFSF15, TL1, VEGI
Domain Architecture
Description	Tumor necrosis factor ligand superfamily member 15 (Vascular endothelial cell growth inhibitor) (TNF ligand-related molecule 1).

TNFC_HUMAN
NC score	0.334857 (rank : 12)	θ value	0.00228821 (rank : 11)
Query Neighborhood Hits	19	Target Neighborhood Hits	25	Shared Neighborhood Hits	14
SwissProt Accessions	Q06643, P78370, Q99761	Gene names	LTB, TNFC, TNFSF3
Domain Architecture
Description	Lymphotoxin-beta (LT-beta) (Tumor necrosis factor C) (TNF-C) (Tumor necrosis factor ligand superfamily member 3).

TNFA_MOUSE
NC score	0.322300 (rank : 13)	θ value	0.0148317 (rank : 12)
Query Neighborhood Hits	19	Target Neighborhood Hits	23	Shared Neighborhood Hits	14
SwissProt Accessions	P06804, O35853, Q62326, Q91VF3	Gene names	Tnf, Tnfa, Tnfsf2
Domain Architecture
Description	Tumor necrosis factor precursor (TNF-alpha) (Tumor necrosis factor ligand superfamily member 2) (TNF-a) (Cachectin) [Contains: Tumor necrosis factor, membrane form; Tumor necrosis factor, soluble form].

TNF14_HUMAN
NC score	0.251151 (rank : 14)	θ value	1.06291 (rank : 16)
Query Neighborhood Hits	19	Target Neighborhood Hits	19	Shared Neighborhood Hits	14
SwissProt Accessions	O43557, O75476, Q8WVF8, Q96LD2	Gene names	TNFSF14, HVEML, LIGHT
Domain Architecture
Description	Tumor necrosis factor ligand superfamily member 14 (Herpesvirus entry mediator-ligand) (HVEM-L) (CD258 antigen) [Contains: Tumor necrosis factor ligand superfamily member 14, membrane form; Tumor necrosis factor ligand superfamily member 14, soluble form].

TNF14_MOUSE
NC score	0.222157 (rank : 15)	θ value	θ > 10 (rank : 20)
Query Neighborhood Hits	19	Target Neighborhood Hits	21	Shared Neighborhood Hits	13
SwissProt Accessions	Q9QYH9	Gene names	Tnfsf14, Light
Domain Architecture
Description	Tumor necrosis factor ligand superfamily member 14 (CD258 antigen) [Contains: Tumor necrosis factor ligand superfamily member 14, membrane form; Tumor necrosis factor ligand superfamily member 14, soluble form].

TNFB_MOUSE
NC score	0.190103 (rank : 16)	θ value	θ > 10 (rank : 22)
Query Neighborhood Hits	19	Target Neighborhood Hits	17	Shared Neighborhood Hits	12
SwissProt Accessions	P09225	Gene names	Lta, Tnfb, Tnfsf1
Domain Architecture
Description	Lymphotoxin-alpha precursor (LT-alpha) (TNF-beta) (Tumor necrosis factor ligand superfamily member 1).

TNFB_HUMAN
NC score	0.186151 (rank : 17)	θ value	θ > 10 (rank : 21)
Query Neighborhood Hits	19	Target Neighborhood Hits	18	Shared Neighborhood Hits	12
SwissProt Accessions	P01374, Q8N4C3, Q9UKS8	Gene names	LTA, TNFB, TNFSF1
Domain Architecture
Description	Lymphotoxin-alpha precursor (LT-alpha) (TNF-beta) (Tumor necrosis factor ligand superfamily member 1).

TNF12_MOUSE
NC score	0.081008 (rank : 18)	θ value	0.62314 (rank : 14)
Query Neighborhood Hits	19	Target Neighborhood Hits	5	Shared Neighborhood Hits	3
SwissProt Accessions	O54907, Q9CTP2	Gene names	Tnfsf12
Domain Architecture
Description	Tumor necrosis factor ligand superfamily member 12 (TNF-related weak inducer of apoptosis) (TWEAK) [Contains: Tumor necrosis factor ligand superfamily member 12, membrane form; Tumor necrosis factor ligand superfamily member 12, secreted form].

TNF12_HUMAN
NC score	0.077051 (rank : 19)	θ value	3.0926 (rank : 17)
Query Neighborhood Hits	19	Target Neighborhood Hits	9	Shared Neighborhood Hits	5
SwissProt Accessions	O43508, Q8WUZ7	Gene names	TNFSF12, APO3L, DR3LG
Domain Architecture
Description	Tumor necrosis factor ligand superfamily member 12 (TNF-related weak inducer of apoptosis) (TWEAK) (APO3 ligand) [Contains: Tumor necrosis factor ligand superfamily member 12, membrane form; Tumor necrosis factor ligand superfamily member 12, secreted form].

TNFL7_HUMAN
NC score	0.065888 (rank : 20)	θ value	0.813845 (rank : 15)
Query Neighborhood Hits	19	Target Neighborhood Hits	5	Shared Neighborhood Hits	2
SwissProt Accessions	P32970, Q96J57	Gene names	TNFSF7, CD27L, CD27LG, CD70
Domain Architecture
Description	Tumor necrosis factor ligand superfamily member 7 (CD27 ligand) (CD27- L) (CD70 antigen).