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Network neighborhood for query Sequence : TNF12_HUMAN

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TNF12_HUMAN
SwissProt Accessions	O43508, Q8WUZ7	Gene names	TNFSF12, APO3L, DR3LG
Domain Architecture
Description	Tumor necrosis factor ligand superfamily member 12 (TNF-related weak inducer of apoptosis) (TWEAK) (APO3 ligand) [Contains: Tumor necrosis factor ligand superfamily member 12, membrane form; Tumor necrosis factor ligand superfamily member 12, secreted form].
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

TNF12_HUMAN
θ value	7.37397e-111 (rank : 1)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	9	Target Neighborhood Hits	9	Shared Neighborhood Hits	9
SwissProt Accessions	O43508, Q8WUZ7	Gene names	TNFSF12, APO3L, DR3LG
Domain Architecture
Description	Tumor necrosis factor ligand superfamily member 12 (TNF-related weak inducer of apoptosis) (TWEAK) (APO3 ligand) [Contains: Tumor necrosis factor ligand superfamily member 12, membrane form; Tumor necrosis factor ligand superfamily member 12, secreted form].

TNF12_MOUSE
θ value	8.4565e-99 (rank : 2)	NC score	0.996706 (rank : 2)
Query Neighborhood Hits	9	Target Neighborhood Hits	5	Shared Neighborhood Hits	3
SwissProt Accessions	O54907, Q9CTP2	Gene names	Tnfsf12
Domain Architecture
Description	Tumor necrosis factor ligand superfamily member 12 (TNF-related weak inducer of apoptosis) (TWEAK) [Contains: Tumor necrosis factor ligand superfamily member 12, membrane form; Tumor necrosis factor ligand superfamily member 12, secreted form].

TNF10_MOUSE
θ value	0.47712 (rank : 3)	NC score	0.081633 (rank : 3)
Query Neighborhood Hits	9	Target Neighborhood Hits	25	Shared Neighborhood Hits	4
SwissProt Accessions	P50592	Gene names	Tnfsf10, Trail
Domain Architecture
Description	Tumor necrosis factor ligand superfamily member 10 (TNF-related apoptosis-inducing ligand) (Protein TRAIL) (CD253 antigen).

TNF10_HUMAN
θ value	1.81305 (rank : 4)	NC score	0.071726 (rank : 5)
Query Neighborhood Hits	9	Target Neighborhood Hits	25	Shared Neighborhood Hits	4
SwissProt Accessions	P50591	Gene names	TNFSF10, APO2L, TRAIL
Domain Architecture
Description	Tumor necrosis factor ligand superfamily member 10 (TNF-related apoptosis-inducing ligand) (Protein TRAIL) (Apo-2 ligand) (Apo-2L) (CD253 antigen).

CD40L_HUMAN
θ value	3.0926 (rank : 5)	NC score	0.077051 (rank : 4)
Query Neighborhood Hits	9	Target Neighborhood Hits	19	Shared Neighborhood Hits	5
SwissProt Accessions	P29965	Gene names	CD40LG, CD40L, TNFSF5, TRAP
Domain Architecture
Description	CD40 ligand (CD40-L) (Tumor necrosis factor ligand superfamily member 5) (TNF-related activation protein) (TRAP) (T cell antigen Gp39) (CD154 antigen) [Contains: CD40 ligand, membrane form; CD40 ligand, soluble form].

JIP1_MOUSE
θ value	5.27518 (rank : 6)	NC score	0.020113 (rank : 6)
Query Neighborhood Hits	9	Target Neighborhood Hits	259	Shared Neighborhood Hits	3
SwissProt Accessions	Q9WVI9, O35145, Q925J8, Q9R1H9, Q9R1Z1, Q9WVI7, Q9WVI8	Gene names	Mapk8ip1, Ib1, Jip1, Mapk8ip, Prkm8ip
Domain Architecture
Description	C-jun-amino-terminal kinase-interacting protein 1 (JNK-interacting protein 1) (JIP-1) (JNK MAP kinase scaffold protein 1) (Islet-brain-1) (IB-1) (Mitogen-activated protein kinase 8-interacting protein 1).

MY18B_HUMAN
θ value	6.88961 (rank : 8)	NC score	0.005979 (rank : 8)
Query Neighborhood Hits	9	Target Neighborhood Hits	1299	Shared Neighborhood Hits	3
SwissProt Accessions	Q8IUG5, Q8NDI8, Q8TE65, Q8WWS0, Q96KH2, Q96KR8, Q96KR9	Gene names	MYO18B
Domain Architecture
Description	Myosin-18B (Myosin XVIIIb).

M4A8B_HUMAN
θ value	8.99809 (rank : 9)	NC score	0.018964 (rank : 7)
Query Neighborhood Hits	9	Target Neighborhood Hits	26	Shared Neighborhood Hits	2
SwissProt Accessions	Q9BY19, Q8TCA5	Gene names	MS4A8B, 4SPAN4
Domain Architecture
Description	Membrane-spanning 4-domains subfamily A member 8B (Four-span transmembrane protein 4).

Hits sorted by NC score

TNF12_HUMAN
NC score	0.999962 (rank : 1)	θ value	7.37397e-111 (rank : 1)
Query Neighborhood Hits	9	Target Neighborhood Hits	9	Shared Neighborhood Hits	9
SwissProt Accessions	O43508, Q8WUZ7	Gene names	TNFSF12, APO3L, DR3LG
Domain Architecture
Description	Tumor necrosis factor ligand superfamily member 12 (TNF-related weak inducer of apoptosis) (TWEAK) (APO3 ligand) [Contains: Tumor necrosis factor ligand superfamily member 12, membrane form; Tumor necrosis factor ligand superfamily member 12, secreted form].

TNF12_MOUSE
NC score	0.996706 (rank : 2)	θ value	8.4565e-99 (rank : 2)
Query Neighborhood Hits	9	Target Neighborhood Hits	5	Shared Neighborhood Hits	3
SwissProt Accessions	O54907, Q9CTP2	Gene names	Tnfsf12
Domain Architecture
Description	Tumor necrosis factor ligand superfamily member 12 (TNF-related weak inducer of apoptosis) (TWEAK) [Contains: Tumor necrosis factor ligand superfamily member 12, membrane form; Tumor necrosis factor ligand superfamily member 12, secreted form].

TNF10_MOUSE
NC score	0.081633 (rank : 3)	θ value	0.47712 (rank : 3)
Query Neighborhood Hits	9	Target Neighborhood Hits	25	Shared Neighborhood Hits	4
SwissProt Accessions	P50592	Gene names	Tnfsf10, Trail
Domain Architecture
Description	Tumor necrosis factor ligand superfamily member 10 (TNF-related apoptosis-inducing ligand) (Protein TRAIL) (CD253 antigen).

CD40L_HUMAN
NC score	0.077051 (rank : 4)	θ value	3.0926 (rank : 5)
Query Neighborhood Hits	9	Target Neighborhood Hits	19	Shared Neighborhood Hits	5
SwissProt Accessions	P29965	Gene names	CD40LG, CD40L, TNFSF5, TRAP
Domain Architecture
Description	CD40 ligand (CD40-L) (Tumor necrosis factor ligand superfamily member 5) (TNF-related activation protein) (TRAP) (T cell antigen Gp39) (CD154 antigen) [Contains: CD40 ligand, membrane form; CD40 ligand, soluble form].

TNF10_HUMAN
NC score	0.071726 (rank : 5)	θ value	1.81305 (rank : 4)
Query Neighborhood Hits	9	Target Neighborhood Hits	25	Shared Neighborhood Hits	4
SwissProt Accessions	P50591	Gene names	TNFSF10, APO2L, TRAIL
Domain Architecture
Description	Tumor necrosis factor ligand superfamily member 10 (TNF-related apoptosis-inducing ligand) (Protein TRAIL) (Apo-2 ligand) (Apo-2L) (CD253 antigen).

JIP1_MOUSE
NC score	0.020113 (rank : 6)	θ value	5.27518 (rank : 6)
Query Neighborhood Hits	9	Target Neighborhood Hits	259	Shared Neighborhood Hits	3
SwissProt Accessions	Q9WVI9, O35145, Q925J8, Q9R1H9, Q9R1Z1, Q9WVI7, Q9WVI8	Gene names	Mapk8ip1, Ib1, Jip1, Mapk8ip, Prkm8ip
Domain Architecture
Description	C-jun-amino-terminal kinase-interacting protein 1 (JNK-interacting protein 1) (JIP-1) (JNK MAP kinase scaffold protein 1) (Islet-brain-1) (IB-1) (Mitogen-activated protein kinase 8-interacting protein 1).

M4A8B_HUMAN
NC score	0.018964 (rank : 7)	θ value	8.99809 (rank : 9)
Query Neighborhood Hits	9	Target Neighborhood Hits	26	Shared Neighborhood Hits	2
SwissProt Accessions	Q9BY19, Q8TCA5	Gene names	MS4A8B, 4SPAN4
Domain Architecture
Description	Membrane-spanning 4-domains subfamily A member 8B (Four-span transmembrane protein 4).

MY18B_HUMAN
NC score	0.005979 (rank : 8)	θ value	6.88961 (rank : 8)
Query Neighborhood Hits	9	Target Neighborhood Hits	1299	Shared Neighborhood Hits	3
SwissProt Accessions	Q8IUG5, Q8NDI8, Q8TE65, Q8WWS0, Q96KH2, Q96KR8, Q96KR9	Gene names	MYO18B
Domain Architecture
Description	Myosin-18B (Myosin XVIIIb).