Please be patient as the page loads

Stop Image Loading/Displaying

Network neighborhood for query Sequence : SPHK1_HUMAN

For an explanation of this page, click here

SPHK1_HUMAN
SwissProt Accessions	Q9NYA1, Q9HD92, Q9NY70, Q9NYL3	Gene names	SPHK1, SPHK, SPK
Domain Architecture
Description	Sphingosine kinase 1 (EC 2.7.1.-) (SK 1) (SPK 1).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

SPHK1_HUMAN
θ value	0 (rank : 1)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	15	Target Neighborhood Hits	15	Shared Neighborhood Hits	15
SwissProt Accessions	Q9NYA1, Q9HD92, Q9NY70, Q9NYL3	Gene names	SPHK1, SPHK, SPK
Domain Architecture
Description	Sphingosine kinase 1 (EC 2.7.1.-) (SK 1) (SPK 1).

SPHK2_MOUSE
θ value	1.01059e-59 (rank : 2)	NC score	0.903254 (rank : 3)
Query Neighborhood Hits	15	Target Neighborhood Hits	78	Shared Neighborhood Hits	9
SwissProt Accessions	Q9JIA7, Q91VA9, Q9DBH6	Gene names	Sphk2
Domain Architecture
Description	Sphingosine kinase 2 (EC 2.7.1.-) (SK 2) (SPK 2).

SPHK2_HUMAN
θ value	3.974e-56 (rank : 3)	NC score	0.903900 (rank : 2)
Query Neighborhood Hits	15	Target Neighborhood Hits	81	Shared Neighborhood Hits	9
SwissProt Accessions	Q9NRA0, Q9BRN1, Q9H0Q2, Q9NWU7	Gene names	SPHK2
Domain Architecture
Description	Sphingosine kinase 2 (EC 2.7.1.-) (SK 2) (SPK 2).

CERK1_HUMAN
θ value	5.07402e-19 (rank : 4)	NC score	0.710523 (rank : 4)
Query Neighborhood Hits	15	Target Neighborhood Hits	10	Shared Neighborhood Hits	8
SwissProt Accessions	Q8TCT0, Q9BYB3, Q9UGE5	Gene names	CERK, KIAA1646
Domain Architecture
Description	Ceramide kinase (EC 2.7.1.138) (Acylsphingosine kinase) (hCERK) (Lipid kinase 4) (LK4).

CERK1_MOUSE
θ value	5.60996e-18 (rank : 5)	NC score	0.699240 (rank : 5)
Query Neighborhood Hits	15	Target Neighborhood Hits	17	Shared Neighborhood Hits	8
SwissProt Accessions	Q8K4Q7	Gene names	Cerk
Domain Architecture
Description	Ceramide kinase (EC 2.7.1.138) (Acylsphingosine kinase) (mCERK).

MULK_HUMAN
θ value	1.16975e-15 (rank : 6)	NC score	0.662407 (rank : 6)
Query Neighborhood Hits	15	Target Neighborhood Hits	13	Shared Neighborhood Hits	9
SwissProt Accessions	Q53H12, Q75KN1, Q96GC3, Q9NP48	Gene names	MULK, AGK
Domain Architecture	No domain graphic available
Description	Multiple substrate lipid kinase, mitochondrial precursor (EC 2.7.1.94) (EC 2.7.1.107) (Multi-substrate lipid kinase) (MuLK) (HsMuLK) (Acylglycerol kinase) (hAGK).

MULK_MOUSE
θ value	7.58209e-15 (rank : 7)	NC score	0.658760 (rank : 7)
Query Neighborhood Hits	15	Target Neighborhood Hits	10	Shared Neighborhood Hits	9
SwissProt Accessions	Q9ESW4, Q9D087	Gene names	Mulk
Domain Architecture	No domain graphic available
Description	Multiple substrate lipid kinase, mitochondrial precursor (EC 2.7.1.94) (EC 2.7.1.107) (Multi-substrate lipid kinase) (MuLK).

CERKL_HUMAN
θ value	2.88788e-06 (rank : 8)	NC score	0.529110 (rank : 8)
Query Neighborhood Hits	15	Target Neighborhood Hits	14	Shared Neighborhood Hits	8
SwissProt Accessions	Q49MI3, Q49MH9, Q49MI0, Q49MI1, Q49MI2, Q5DVJ2, Q5DVJ4, Q5DVJ5, Q6UZF6, Q6ZP59	Gene names	CERKL
Domain Architecture	No domain graphic available
Description	Ceramide kinase-like protein.

DGKI_HUMAN
θ value	0.21417 (rank : 9)	NC score	0.051472 (rank : 9)
Query Neighborhood Hits	15	Target Neighborhood Hits	609	Shared Neighborhood Hits	6
SwissProt Accessions	O75912, Q9NZ49	Gene names	DGKI
Domain Architecture
Description	Diacylglycerol kinase iota (EC 2.7.1.107) (Diglyceride kinase iota) (DGK-iota) (DAG kinase iota).

ORAI3_MOUSE
θ value	1.38821 (rank : 10)	NC score	0.034615 (rank : 10)
Query Neighborhood Hits	15	Target Neighborhood Hits	26	Shared Neighborhood Hits	3
SwissProt Accessions	Q6P8G8	Gene names	Tmem142c, Orai3
Domain Architecture	No domain graphic available
Description	Protein orai-3 (Transmembrane protein 142C).

AATF_MOUSE
θ value	6.88961 (rank : 11)	NC score	0.019230 (rank : 12)
Query Neighborhood Hits	15	Target Neighborhood Hits	50	Shared Neighborhood Hits	2
SwissProt Accessions	Q9JKX4, Q7TQN1, Q8C5Q2, Q99P89	Gene names	Aatf, Che1, Trb
Domain Architecture	No domain graphic available
Description	Protein AATF (Apoptosis-antagonizing transcription factor) (Rb-binding protein Che-1) (Traube protein).

ORAI3_HUMAN
θ value	6.88961 (rank : 12)	NC score	0.027095 (rank : 11)
Query Neighborhood Hits	15	Target Neighborhood Hits	10	Shared Neighborhood Hits	3
SwissProt Accessions	Q9BRQ5, Q96BI8	Gene names	TMEM142C, ORAI3
Domain Architecture	No domain graphic available
Description	Protein orai-3 (Transmembrane protein 142C).

MTSS1_HUMAN
θ value	8.99809 (rank : 13)	NC score	0.017182 (rank : 13)
Query Neighborhood Hits	15	Target Neighborhood Hits	504	Shared Neighborhood Hits	3
SwissProt Accessions	O43312, Q8TCA2, Q96RX2	Gene names	MTSS1, KIAA0429, MIM
Domain Architecture	No domain graphic available
Description	Metastasis suppressor protein 1 (Missing in metastasis protein) (Metastasis suppressor YGL-1).

MTSS1_MOUSE
θ value	8.99809 (rank : 14)	NC score	0.016184 (rank : 15)
Query Neighborhood Hits	15	Target Neighborhood Hits	592	Shared Neighborhood Hits	3
SwissProt Accessions	Q8R1S4, Q8BMM3, Q99LB3	Gene names	Mtss1, Mim
Domain Architecture	No domain graphic available
Description	Metastasis suppressor protein 1 (Missing in metastasis protein).

SF3B3_HUMAN
θ value	8.99809 (rank : 15)	NC score	0.016977 (rank : 14)
Query Neighborhood Hits	15	Target Neighborhood Hits	19	Shared Neighborhood Hits	2
SwissProt Accessions	Q15393, Q9UJ29	Gene names	SF3B3, KIAA0017, SAP130
Domain Architecture
Description	Splicing factor 3B subunit 3 (Spliceosome-associated protein 130) (SAP 130) (SF3b130) (Pre-mRNA-splicing factor SF3b 130 kDa subunit) (STAF130).

Hits sorted by NC score

SPHK1_HUMAN
NC score	0.999962 (rank : 1)	θ value	0 (rank : 1)
Query Neighborhood Hits	15	Target Neighborhood Hits	15	Shared Neighborhood Hits	15
SwissProt Accessions	Q9NYA1, Q9HD92, Q9NY70, Q9NYL3	Gene names	SPHK1, SPHK, SPK
Domain Architecture
Description	Sphingosine kinase 1 (EC 2.7.1.-) (SK 1) (SPK 1).

SPHK2_HUMAN
NC score	0.903900 (rank : 2)	θ value	3.974e-56 (rank : 3)
Query Neighborhood Hits	15	Target Neighborhood Hits	81	Shared Neighborhood Hits	9
SwissProt Accessions	Q9NRA0, Q9BRN1, Q9H0Q2, Q9NWU7	Gene names	SPHK2
Domain Architecture
Description	Sphingosine kinase 2 (EC 2.7.1.-) (SK 2) (SPK 2).

SPHK2_MOUSE
NC score	0.903254 (rank : 3)	θ value	1.01059e-59 (rank : 2)
Query Neighborhood Hits	15	Target Neighborhood Hits	78	Shared Neighborhood Hits	9
SwissProt Accessions	Q9JIA7, Q91VA9, Q9DBH6	Gene names	Sphk2
Domain Architecture
Description	Sphingosine kinase 2 (EC 2.7.1.-) (SK 2) (SPK 2).

CERK1_HUMAN
NC score	0.710523 (rank : 4)	θ value	5.07402e-19 (rank : 4)
Query Neighborhood Hits	15	Target Neighborhood Hits	10	Shared Neighborhood Hits	8
SwissProt Accessions	Q8TCT0, Q9BYB3, Q9UGE5	Gene names	CERK, KIAA1646
Domain Architecture
Description	Ceramide kinase (EC 2.7.1.138) (Acylsphingosine kinase) (hCERK) (Lipid kinase 4) (LK4).

CERK1_MOUSE
NC score	0.699240 (rank : 5)	θ value	5.60996e-18 (rank : 5)
Query Neighborhood Hits	15	Target Neighborhood Hits	17	Shared Neighborhood Hits	8
SwissProt Accessions	Q8K4Q7	Gene names	Cerk
Domain Architecture
Description	Ceramide kinase (EC 2.7.1.138) (Acylsphingosine kinase) (mCERK).

MULK_HUMAN
NC score	0.662407 (rank : 6)	θ value	1.16975e-15 (rank : 6)
Query Neighborhood Hits	15	Target Neighborhood Hits	13	Shared Neighborhood Hits	9
SwissProt Accessions	Q53H12, Q75KN1, Q96GC3, Q9NP48	Gene names	MULK, AGK
Domain Architecture	No domain graphic available
Description	Multiple substrate lipid kinase, mitochondrial precursor (EC 2.7.1.94) (EC 2.7.1.107) (Multi-substrate lipid kinase) (MuLK) (HsMuLK) (Acylglycerol kinase) (hAGK).

MULK_MOUSE
NC score	0.658760 (rank : 7)	θ value	7.58209e-15 (rank : 7)
Query Neighborhood Hits	15	Target Neighborhood Hits	10	Shared Neighborhood Hits	9
SwissProt Accessions	Q9ESW4, Q9D087	Gene names	Mulk
Domain Architecture	No domain graphic available
Description	Multiple substrate lipid kinase, mitochondrial precursor (EC 2.7.1.94) (EC 2.7.1.107) (Multi-substrate lipid kinase) (MuLK).

CERKL_HUMAN
NC score	0.529110 (rank : 8)	θ value	2.88788e-06 (rank : 8)
Query Neighborhood Hits	15	Target Neighborhood Hits	14	Shared Neighborhood Hits	8
SwissProt Accessions	Q49MI3, Q49MH9, Q49MI0, Q49MI1, Q49MI2, Q5DVJ2, Q5DVJ4, Q5DVJ5, Q6UZF6, Q6ZP59	Gene names	CERKL
Domain Architecture	No domain graphic available
Description	Ceramide kinase-like protein.

DGKI_HUMAN
NC score	0.051472 (rank : 9)	θ value	0.21417 (rank : 9)
Query Neighborhood Hits	15	Target Neighborhood Hits	609	Shared Neighborhood Hits	6
SwissProt Accessions	O75912, Q9NZ49	Gene names	DGKI
Domain Architecture
Description	Diacylglycerol kinase iota (EC 2.7.1.107) (Diglyceride kinase iota) (DGK-iota) (DAG kinase iota).

ORAI3_MOUSE
NC score	0.034615 (rank : 10)	θ value	1.38821 (rank : 10)
Query Neighborhood Hits	15	Target Neighborhood Hits	26	Shared Neighborhood Hits	3
SwissProt Accessions	Q6P8G8	Gene names	Tmem142c, Orai3
Domain Architecture	No domain graphic available
Description	Protein orai-3 (Transmembrane protein 142C).

ORAI3_HUMAN
NC score	0.027095 (rank : 11)	θ value	6.88961 (rank : 12)
Query Neighborhood Hits	15	Target Neighborhood Hits	10	Shared Neighborhood Hits	3
SwissProt Accessions	Q9BRQ5, Q96BI8	Gene names	TMEM142C, ORAI3
Domain Architecture	No domain graphic available
Description	Protein orai-3 (Transmembrane protein 142C).

AATF_MOUSE
NC score	0.019230 (rank : 12)	θ value	6.88961 (rank : 11)
Query Neighborhood Hits	15	Target Neighborhood Hits	50	Shared Neighborhood Hits	2
SwissProt Accessions	Q9JKX4, Q7TQN1, Q8C5Q2, Q99P89	Gene names	Aatf, Che1, Trb
Domain Architecture	No domain graphic available
Description	Protein AATF (Apoptosis-antagonizing transcription factor) (Rb-binding protein Che-1) (Traube protein).

MTSS1_HUMAN
NC score	0.017182 (rank : 13)	θ value	8.99809 (rank : 13)
Query Neighborhood Hits	15	Target Neighborhood Hits	504	Shared Neighborhood Hits	3
SwissProt Accessions	O43312, Q8TCA2, Q96RX2	Gene names	MTSS1, KIAA0429, MIM
Domain Architecture	No domain graphic available
Description	Metastasis suppressor protein 1 (Missing in metastasis protein) (Metastasis suppressor YGL-1).

SF3B3_HUMAN
NC score	0.016977 (rank : 14)	θ value	8.99809 (rank : 15)
Query Neighborhood Hits	15	Target Neighborhood Hits	19	Shared Neighborhood Hits	2
SwissProt Accessions	Q15393, Q9UJ29	Gene names	SF3B3, KIAA0017, SAP130
Domain Architecture
Description	Splicing factor 3B subunit 3 (Spliceosome-associated protein 130) (SAP 130) (SF3b130) (Pre-mRNA-splicing factor SF3b 130 kDa subunit) (STAF130).

MTSS1_MOUSE
NC score	0.016184 (rank : 15)	θ value	8.99809 (rank : 14)
Query Neighborhood Hits	15	Target Neighborhood Hits	592	Shared Neighborhood Hits	3
SwissProt Accessions	Q8R1S4, Q8BMM3, Q99LB3	Gene names	Mtss1, Mim
Domain Architecture	No domain graphic available
Description	Metastasis suppressor protein 1 (Missing in metastasis protein).