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Network neighborhood for query Sequence : CERK1_HUMAN

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CERK1_HUMAN
SwissProt Accessions	Q8TCT0, Q9BYB3, Q9UGE5	Gene names	CERK, KIAA1646
Domain Architecture
Description	Ceramide kinase (EC 2.7.1.138) (Acylsphingosine kinase) (hCERK) (Lipid kinase 4) (LK4).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

CERK1_HUMAN
θ value	0 (rank : 1)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	10	Target Neighborhood Hits	10	Shared Neighborhood Hits	10
SwissProt Accessions	Q8TCT0, Q9BYB3, Q9UGE5	Gene names	CERK, KIAA1646
Domain Architecture
Description	Ceramide kinase (EC 2.7.1.138) (Acylsphingosine kinase) (hCERK) (Lipid kinase 4) (LK4).

CERK1_MOUSE
θ value	0 (rank : 2)	NC score	0.997655 (rank : 2)
Query Neighborhood Hits	10	Target Neighborhood Hits	17	Shared Neighborhood Hits	8
SwissProt Accessions	Q8K4Q7	Gene names	Cerk
Domain Architecture
Description	Ceramide kinase (EC 2.7.1.138) (Acylsphingosine kinase) (mCERK).

CERKL_HUMAN
θ value	1.788e-48 (rank : 3)	NC score	0.848989 (rank : 3)
Query Neighborhood Hits	10	Target Neighborhood Hits	14	Shared Neighborhood Hits	8
SwissProt Accessions	Q49MI3, Q49MH9, Q49MI0, Q49MI1, Q49MI2, Q5DVJ2, Q5DVJ4, Q5DVJ5, Q6UZF6, Q6ZP59	Gene names	CERKL
Domain Architecture	No domain graphic available
Description	Ceramide kinase-like protein.

SPHK2_HUMAN
θ value	8.36355e-22 (rank : 4)	NC score	0.655657 (rank : 5)
Query Neighborhood Hits	10	Target Neighborhood Hits	81	Shared Neighborhood Hits	8
SwissProt Accessions	Q9NRA0, Q9BRN1, Q9H0Q2, Q9NWU7	Gene names	SPHK2
Domain Architecture
Description	Sphingosine kinase 2 (EC 2.7.1.-) (SK 2) (SPK 2).

SPHK2_MOUSE
θ value	3.17815e-21 (rank : 5)	NC score	0.647346 (rank : 6)
Query Neighborhood Hits	10	Target Neighborhood Hits	78	Shared Neighborhood Hits	8
SwissProt Accessions	Q9JIA7, Q91VA9, Q9DBH6	Gene names	Sphk2
Domain Architecture
Description	Sphingosine kinase 2 (EC 2.7.1.-) (SK 2) (SPK 2).

SPHK1_HUMAN
θ value	5.07402e-19 (rank : 6)	NC score	0.710523 (rank : 4)
Query Neighborhood Hits	10	Target Neighborhood Hits	15	Shared Neighborhood Hits	8
SwissProt Accessions	Q9NYA1, Q9HD92, Q9NY70, Q9NYL3	Gene names	SPHK1, SPHK, SPK
Domain Architecture
Description	Sphingosine kinase 1 (EC 2.7.1.-) (SK 1) (SPK 1).

MULK_MOUSE
θ value	5.43371e-13 (rank : 7)	NC score	0.582521 (rank : 7)
Query Neighborhood Hits	10	Target Neighborhood Hits	10	Shared Neighborhood Hits	8
SwissProt Accessions	Q9ESW4, Q9D087	Gene names	Mulk
Domain Architecture	No domain graphic available
Description	Multiple substrate lipid kinase, mitochondrial precursor (EC 2.7.1.94) (EC 2.7.1.107) (Multi-substrate lipid kinase) (MuLK).

MULK_HUMAN
θ value	2.0648e-12 (rank : 8)	NC score	0.576305 (rank : 8)
Query Neighborhood Hits	10	Target Neighborhood Hits	13	Shared Neighborhood Hits	8
SwissProt Accessions	Q53H12, Q75KN1, Q96GC3, Q9NP48	Gene names	MULK, AGK
Domain Architecture	No domain graphic available
Description	Multiple substrate lipid kinase, mitochondrial precursor (EC 2.7.1.94) (EC 2.7.1.107) (Multi-substrate lipid kinase) (MuLK) (HsMuLK) (Acylglycerol kinase) (hAGK).

FA35A_MOUSE
θ value	6.88961 (rank : 9)	NC score	0.016691 (rank : 9)
Query Neighborhood Hits	10	Target Neighborhood Hits	54	Shared Neighborhood Hits	2
SwissProt Accessions	Q3UEN2	Gene names	Fam35a
Domain Architecture	No domain graphic available
Description	Protein FAM35A.

PGDH_MOUSE
θ value	8.99809 (rank : 10)	NC score	0.007439 (rank : 10)
Query Neighborhood Hits	10	Target Neighborhood Hits	73	Shared Neighborhood Hits	2
SwissProt Accessions	Q8VCC1, Q61106	Gene names	Hpgd, Pgdh1
Domain Architecture	No domain graphic available
Description	15-hydroxyprostaglandin dehydrogenase [NAD+] (EC 1.1.1.141) (PGDH) (Prostaglandin dehydrogenase 1).

Hits sorted by NC score

CERK1_HUMAN
NC score	0.999962 (rank : 1)	θ value	0 (rank : 1)
Query Neighborhood Hits	10	Target Neighborhood Hits	10	Shared Neighborhood Hits	10
SwissProt Accessions	Q8TCT0, Q9BYB3, Q9UGE5	Gene names	CERK, KIAA1646
Domain Architecture
Description	Ceramide kinase (EC 2.7.1.138) (Acylsphingosine kinase) (hCERK) (Lipid kinase 4) (LK4).

CERK1_MOUSE
NC score	0.997655 (rank : 2)	θ value	0 (rank : 2)
Query Neighborhood Hits	10	Target Neighborhood Hits	17	Shared Neighborhood Hits	8
SwissProt Accessions	Q8K4Q7	Gene names	Cerk
Domain Architecture
Description	Ceramide kinase (EC 2.7.1.138) (Acylsphingosine kinase) (mCERK).

CERKL_HUMAN
NC score	0.848989 (rank : 3)	θ value	1.788e-48 (rank : 3)
Query Neighborhood Hits	10	Target Neighborhood Hits	14	Shared Neighborhood Hits	8
SwissProt Accessions	Q49MI3, Q49MH9, Q49MI0, Q49MI1, Q49MI2, Q5DVJ2, Q5DVJ4, Q5DVJ5, Q6UZF6, Q6ZP59	Gene names	CERKL
Domain Architecture	No domain graphic available
Description	Ceramide kinase-like protein.

SPHK1_HUMAN
NC score	0.710523 (rank : 4)	θ value	5.07402e-19 (rank : 6)
Query Neighborhood Hits	10	Target Neighborhood Hits	15	Shared Neighborhood Hits	8
SwissProt Accessions	Q9NYA1, Q9HD92, Q9NY70, Q9NYL3	Gene names	SPHK1, SPHK, SPK
Domain Architecture
Description	Sphingosine kinase 1 (EC 2.7.1.-) (SK 1) (SPK 1).

SPHK2_HUMAN
NC score	0.655657 (rank : 5)	θ value	8.36355e-22 (rank : 4)
Query Neighborhood Hits	10	Target Neighborhood Hits	81	Shared Neighborhood Hits	8
SwissProt Accessions	Q9NRA0, Q9BRN1, Q9H0Q2, Q9NWU7	Gene names	SPHK2
Domain Architecture
Description	Sphingosine kinase 2 (EC 2.7.1.-) (SK 2) (SPK 2).

SPHK2_MOUSE
NC score	0.647346 (rank : 6)	θ value	3.17815e-21 (rank : 5)
Query Neighborhood Hits	10	Target Neighborhood Hits	78	Shared Neighborhood Hits	8
SwissProt Accessions	Q9JIA7, Q91VA9, Q9DBH6	Gene names	Sphk2
Domain Architecture
Description	Sphingosine kinase 2 (EC 2.7.1.-) (SK 2) (SPK 2).

MULK_MOUSE
NC score	0.582521 (rank : 7)	θ value	5.43371e-13 (rank : 7)
Query Neighborhood Hits	10	Target Neighborhood Hits	10	Shared Neighborhood Hits	8
SwissProt Accessions	Q9ESW4, Q9D087	Gene names	Mulk
Domain Architecture	No domain graphic available
Description	Multiple substrate lipid kinase, mitochondrial precursor (EC 2.7.1.94) (EC 2.7.1.107) (Multi-substrate lipid kinase) (MuLK).

MULK_HUMAN
NC score	0.576305 (rank : 8)	θ value	2.0648e-12 (rank : 8)
Query Neighborhood Hits	10	Target Neighborhood Hits	13	Shared Neighborhood Hits	8
SwissProt Accessions	Q53H12, Q75KN1, Q96GC3, Q9NP48	Gene names	MULK, AGK
Domain Architecture	No domain graphic available
Description	Multiple substrate lipid kinase, mitochondrial precursor (EC 2.7.1.94) (EC 2.7.1.107) (Multi-substrate lipid kinase) (MuLK) (HsMuLK) (Acylglycerol kinase) (hAGK).

FA35A_MOUSE
NC score	0.016691 (rank : 9)	θ value	6.88961 (rank : 9)
Query Neighborhood Hits	10	Target Neighborhood Hits	54	Shared Neighborhood Hits	2
SwissProt Accessions	Q3UEN2	Gene names	Fam35a
Domain Architecture	No domain graphic available
Description	Protein FAM35A.

PGDH_MOUSE
NC score	0.007439 (rank : 10)	θ value	8.99809 (rank : 10)
Query Neighborhood Hits	10	Target Neighborhood Hits	73	Shared Neighborhood Hits	2
SwissProt Accessions	Q8VCC1, Q61106	Gene names	Hpgd, Pgdh1
Domain Architecture	No domain graphic available
Description	15-hydroxyprostaglandin dehydrogenase [NAD+] (EC 1.1.1.141) (PGDH) (Prostaglandin dehydrogenase 1).