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Network neighborhood for query Sequence : ITIH4_HUMAN

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ITIH4_HUMAN
SwissProt Accessions	Q14624, Q15135, Q9P190, Q9UQ54	Gene names	ITIH4, IHRP, ITIHL1, PK120
Domain Architecture
Description	Inter-alpha-trypsin inhibitor heavy chain H4 precursor (ITI heavy chain H4) (Inter-alpha-inhibitor heavy chain 4) (Inter-alpha-trypsin inhibitor family heavy chain-related protein) (IHRP) (Plasma kallikrein sensitive glycoprotein 120) (PK-120) (GP120) [Contains: 70 kDa inter-alpha-trypsin inhibitor heavy chain H4; 35 kDa inter-alpha- trypsin inhibitor heavy chain H4].
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

ITIH4_HUMAN
θ value	0 (rank : 1)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	46	Target Neighborhood Hits	46	Shared Neighborhood Hits	46
SwissProt Accessions	Q14624, Q15135, Q9P190, Q9UQ54	Gene names	ITIH4, IHRP, ITIHL1, PK120
Domain Architecture
Description	Inter-alpha-trypsin inhibitor heavy chain H4 precursor (ITI heavy chain H4) (Inter-alpha-inhibitor heavy chain 4) (Inter-alpha-trypsin inhibitor family heavy chain-related protein) (IHRP) (Plasma kallikrein sensitive glycoprotein 120) (PK-120) (GP120) [Contains: 70 kDa inter-alpha-trypsin inhibitor heavy chain H4; 35 kDa inter-alpha- trypsin inhibitor heavy chain H4].

ITIH3_HUMAN
θ value	1.36511e-173 (rank : 2)	NC score	0.971576 (rank : 2)
Query Neighborhood Hits	46	Target Neighborhood Hits	38	Shared Neighborhood Hits	14
SwissProt Accessions	Q06033, Q99085	Gene names	ITIH3
Domain Architecture
Description	Inter-alpha-trypsin inhibitor heavy chain H3 precursor (ITI heavy chain H3) (Inter-alpha-inhibitor heavy chain 3) (Serum-derived hyaluronan-associated protein) (SHAP).

ITIH3_MOUSE
θ value	5.73535e-172 (rank : 3)	NC score	0.971223 (rank : 3)
Query Neighborhood Hits	46	Target Neighborhood Hits	34	Shared Neighborhood Hits	16
SwissProt Accessions	Q61704	Gene names	Itih3
Domain Architecture
Description	Inter-alpha-trypsin inhibitor heavy chain H3 precursor (ITI heavy chain H3) (Inter-alpha-inhibitor heavy chain 3).

ITIH2_HUMAN
θ value	2.97304e-136 (rank : 4)	NC score	0.952003 (rank : 7)
Query Neighborhood Hits	46	Target Neighborhood Hits	29	Shared Neighborhood Hits	10
SwissProt Accessions	P19823, Q14659, Q15484	Gene names	ITIH2, IGHEP2
Domain Architecture
Description	Inter-alpha-trypsin inhibitor heavy chain H2 precursor (ITI heavy chain H2) (Inter-alpha-inhibitor heavy chain 2) (Inter-alpha-trypsin inhibitor complex component II) (Serum-derived hyaluronan-associated protein) (SHAP).

ITIH1_MOUSE
θ value	2.13063e-134 (rank : 5)	NC score	0.963252 (rank : 5)
Query Neighborhood Hits	46	Target Neighborhood Hits	31	Shared Neighborhood Hits	16
SwissProt Accessions	Q61702	Gene names	Itih1
Domain Architecture
Description	Inter-alpha-trypsin inhibitor heavy chain H1 precursor (ITI heavy chain H1) (Inter-alpha-inhibitor heavy chain 1).

ITIH1_HUMAN
θ value	6.19918e-134 (rank : 6)	NC score	0.963784 (rank : 4)
Query Neighborhood Hits	46	Target Neighborhood Hits	30	Shared Neighborhood Hits	14
SwissProt Accessions	P19827, P78455, Q01746	Gene names	ITIH1, IGHEP1
Domain Architecture
Description	Inter-alpha-trypsin inhibitor heavy chain H1 precursor (ITI heavy chain H1) (Inter-alpha-inhibitor heavy chain 1) (Inter-alpha-trypsin inhibitor complex component III) (Serum-derived hyaluronan-associated protein) (SHAP).

ITIH2_MOUSE
θ value	7.57797e-132 (rank : 7)	NC score	0.955242 (rank : 6)
Query Neighborhood Hits	46	Target Neighborhood Hits	27	Shared Neighborhood Hits	14
SwissProt Accessions	Q61703	Gene names	Itih2
Domain Architecture
Description	Inter-alpha-trypsin inhibitor heavy chain H2 precursor (ITI heavy chain H2) (Inter-alpha-inhibitor heavy chain 2).

PARP4_HUMAN
θ value	5.08577e-11 (rank : 8)	NC score	0.344964 (rank : 10)
Query Neighborhood Hits	46	Target Neighborhood Hits	93	Shared Neighborhood Hits	12
SwissProt Accessions	Q9UKK3, O75903, Q14682, Q9H1M6	Gene names	PARP4, ADPRTL1, KIAA0177, PARPL
Domain Architecture
Description	Poly [ADP-ribose] polymerase 4 (EC 2.4.2.30) (PARP-4) (Vault poly(ADP- ribose) polymerase) (VPARP) (193 kDa vault protein) (PARP- related/IalphaI-related H5/proline-rich) (PH5P).

LHR2A_HUMAN
θ value	1.47974e-10 (rank : 9)	NC score	0.375774 (rank : 8)
Query Neighborhood Hits	46	Target Neighborhood Hits	16	Shared Neighborhood Hits	8
SwissProt Accessions	O00534, Q6UN19, Q6UN20, Q9BVF8	Gene names	LOH11CR2A, BCSC1
Domain Architecture
Description	Loss of heterozygosity 11 chromosomal region 2 gene A protein (Breast cancer suppressor candidate 1) (BCSC-1).

LHR2A_MOUSE
θ value	8.11959e-09 (rank : 10)	NC score	0.352299 (rank : 9)
Query Neighborhood Hits	46	Target Neighborhood Hits	16	Shared Neighborhood Hits	9
SwissProt Accessions	Q99KC8, Q3TTU2, Q6UN22, Q8BHA8, Q9CTV9	Gene names	Loh11cr2a
Domain Architecture
Description	Loss of heterozygosity 11 chromosomal region 2 gene A protein homolog.

CAC2D_HUMAN
θ value	7.1131e-05 (rank : 11)	NC score	0.311470 (rank : 12)
Query Neighborhood Hits	46	Target Neighborhood Hits	32	Shared Neighborhood Hits	13
SwissProt Accessions	P54289	Gene names	CACNA2D1, CACNL2A, CCHL2A
Domain Architecture
Description	Dihydropyridine-sensitive L-type calcium channel subunits alpha- 2/delta precursor [Contains: L-type calcium channel subunit alpha-2; L-type calcium channel subunit delta].

CAC2D_MOUSE
θ value	0.000270298 (rank : 12)	NC score	0.311689 (rank : 11)
Query Neighborhood Hits	46	Target Neighborhood Hits	42	Shared Neighborhood Hits	17
SwissProt Accessions	O08532, O08533, O08534, O08535, O08536	Gene names	Cacna2d1, Cacna2
Domain Architecture
Description	Dihydropyridine-sensitive L-type calcium channel subunits alpha- 2/delta precursor [Contains: L-type calcium channel subunit alpha-2; L-type calcium channel subunit delta].

ANTR2_MOUSE
θ value	0.000461057 (rank : 13)	NC score	0.088993 (rank : 13)
Query Neighborhood Hits	46	Target Neighborhood Hits	26	Shared Neighborhood Hits	8
SwissProt Accessions	Q6DFX2, Q99L17	Gene names	Antxr2
Domain Architecture	No domain graphic available
Description	Anthrax toxin receptor 2 precursor.

ANTR2_HUMAN
θ value	0.00665767 (rank : 14)	NC score	0.079766 (rank : 14)
Query Neighborhood Hits	46	Target Neighborhood Hits	34	Shared Neighborhood Hits	7
SwissProt Accessions	P58335, Q59E98, Q5JPE9, Q86UI1, Q8N4J8, Q8NB13, Q96NC7	Gene names	ANTXR2, CMG2
Domain Architecture
Description	Anthrax toxin receptor 2 precursor (Capillary morphogenesis gene 2 protein) (CMG-2).

CO6A1_HUMAN
θ value	0.21417 (rank : 15)	NC score	0.034466 (rank : 18)
Query Neighborhood Hits	46	Target Neighborhood Hits	264	Shared Neighborhood Hits	14
SwissProt Accessions	P12109, O00117, O00118, Q14040, Q14041, Q16258	Gene names	COL6A1
Domain Architecture
Description	Collagen alpha-1(VI) chain precursor.

CO6A1_MOUSE
θ value	0.365318 (rank : 16)	NC score	0.039670 (rank : 17)
Query Neighborhood Hits	46	Target Neighborhood Hits	241	Shared Neighborhood Hits	14
SwissProt Accessions	Q04857	Gene names	Col6a1
Domain Architecture
Description	Collagen alpha-1(VI) chain precursor.

MATN1_MOUSE
θ value	0.47712 (rank : 17)	NC score	0.059169 (rank : 15)
Query Neighborhood Hits	46	Target Neighborhood Hits	186	Shared Neighborhood Hits	17
SwissProt Accessions	P51942	Gene names	Matn1, Cmp, Crtm
Domain Architecture
Description	Cartilage matrix protein precursor (Matrilin-1).

ITAM_MOUSE
θ value	0.813845 (rank : 18)	NC score	0.029940 (rank : 20)
Query Neighborhood Hits	46	Target Neighborhood Hits	77	Shared Neighborhood Hits	15
SwissProt Accessions	P05555, Q8CA73	Gene names	Itgam
Domain Architecture
Description	Integrin alpha-M precursor (Cell surface glycoprotein MAC-1 alpha subunit) (CR-3 alpha chain) (Leukocyte adhesion receptor MO1) (CD11b antigen).

FCGR1_MOUSE
θ value	1.06291 (rank : 19)	NC score	0.016805 (rank : 26)
Query Neighborhood Hits	46	Target Neighborhood Hits	123	Shared Neighborhood Hits	3
SwissProt Accessions	P26151	Gene names	Fcgr1, Fcg1
Domain Architecture
Description	High affinity immunoglobulin gamma Fc receptor I precursor (Fc-gamma RI) (FcRI) (IgG Fc receptor I).

PRRT3_MOUSE
θ value	1.06291 (rank : 20)	NC score	0.033362 (rank : 19)
Query Neighborhood Hits	46	Target Neighborhood Hits	162	Shared Neighborhood Hits	4
SwissProt Accessions	Q6PE13	Gene names	Prrt3
Domain Architecture	No domain graphic available
Description	Proline-rich transmembrane protein 3.

FLNA_MOUSE
θ value	1.38821 (rank : 21)	NC score	0.016477 (rank : 27)
Query Neighborhood Hits	46	Target Neighborhood Hits	142	Shared Neighborhood Hits	4
SwissProt Accessions	Q8BTM8, O54934, Q7TQI1, Q8BLK1, Q8BTN7, Q8VHX5, Q8VHX8, Q99KQ2	Gene names	Flna, Fln, Fln1
Domain Architecture
Description	Filamin-A (Alpha-filamin) (Filamin-1) (Endothelial actin-binding protein) (Actin-binding protein 280) (ABP-280) (Nonmuscle filamin).

CAYP2_HUMAN
θ value	1.81305 (rank : 22)	NC score	0.022343 (rank : 23)
Query Neighborhood Hits	46	Target Neighborhood Hits	98	Shared Neighborhood Hits	2
SwissProt Accessions	Q9BXY5, Q6PH84, Q8N242, Q8NAY5	Gene names	CAPS2
Domain Architecture
Description	Calcyphosin-2 (Calcyphosine-2).

FLNA_HUMAN
θ value	1.81305 (rank : 23)	NC score	0.016121 (rank : 28)
Query Neighborhood Hits	46	Target Neighborhood Hits	138	Shared Neighborhood Hits	4
SwissProt Accessions	P21333	Gene names	FLNA, FLN, FLN1
Domain Architecture
Description	Filamin-A (Alpha-filamin) (Filamin-1) (Endothelial actin-binding protein) (Actin-binding protein 280) (ABP-280) (Nonmuscle filamin).

GNDS_HUMAN
θ value	1.81305 (rank : 24)	NC score	0.013456 (rank : 31)
Query Neighborhood Hits	46	Target Neighborhood Hits	201	Shared Neighborhood Hits	4
SwissProt Accessions	Q12967, Q9HAX7, Q9HAY1, Q9HCT1	Gene names	RALGDS, RGF
Domain Architecture
Description	Ral guanine nucleotide dissociation stimulator (RalGEF) (RalGDS).

ITAM_HUMAN
θ value	1.81305 (rank : 25)	NC score	0.027599 (rank : 21)
Query Neighborhood Hits	46	Target Neighborhood Hits	78	Shared Neighborhood Hits	12
SwissProt Accessions	P11215	Gene names	ITGAM, CD11B, CR3A
Domain Architecture
Description	Integrin alpha-M precursor (Cell surface glycoprotein MAC-1 alpha subunit) (CR-3 alpha chain) (Leukocyte adhesion receptor MO1) (Neutrophil adherence receptor) (CD11b antigen).

MATN1_HUMAN
θ value	1.81305 (rank : 26)	NC score	0.052438 (rank : 16)
Query Neighborhood Hits	46	Target Neighborhood Hits	191	Shared Neighborhood Hits	17
SwissProt Accessions	P21941	Gene names	MATN1, CMP, CRTM
Domain Architecture
Description	Cartilage matrix protein precursor (Matrilin-1).

EM55_MOUSE
θ value	2.36792 (rank : 27)	NC score	0.011454 (rank : 33)
Query Neighborhood Hits	46	Target Neighborhood Hits	221	Shared Neighborhood Hits	3
SwissProt Accessions	P70290	Gene names	Mpp1
Domain Architecture
Description	55 kDa erythrocyte membrane protein (p55) (Membrane protein, palmitoylated 1) (Palmitoylated protein p55).

MATN4_HUMAN
θ value	2.36792 (rank : 28)	NC score	0.020906 (rank : 25)
Query Neighborhood Hits	46	Target Neighborhood Hits	287	Shared Neighborhood Hits	12
SwissProt Accessions	O95460, Q5QPU2, Q5QPU3, Q5QPU4, Q8N2M5, Q8N2M7, Q9H1F8, Q9H1F9	Gene names	MATN4
Domain Architecture
Description	Matrilin-4 precursor.

PABP1_HUMAN
θ value	3.0926 (rank : 29)	NC score	0.009654 (rank : 38)
Query Neighborhood Hits	46	Target Neighborhood Hits	269	Shared Neighborhood Hits	4
SwissProt Accessions	P11940, Q15097, Q93004	Gene names	PABPC1, PAB1, PABP1, PABPC2
Domain Architecture
Description	Polyadenylate-binding protein 1 (Poly(A)-binding protein 1) (PABP 1).

PABP1_MOUSE
θ value	3.0926 (rank : 30)	NC score	0.009633 (rank : 39)
Query Neighborhood Hits	46	Target Neighborhood Hits	278	Shared Neighborhood Hits	4
SwissProt Accessions	P29341	Gene names	Pabpc1, Pabp1
Domain Architecture
Description	Polyadenylate-binding protein 1 (Poly(A)-binding protein 1) (PABP 1).

RFIP1_HUMAN
θ value	3.0926 (rank : 31)	NC score	0.014191 (rank : 30)
Query Neighborhood Hits	46	Target Neighborhood Hits	236	Shared Neighborhood Hits	4
SwissProt Accessions	Q6WKZ4, Q6AZK4, Q6WKZ2, Q6WKZ6, Q86YV4, Q8TDL1, Q9H642	Gene names	RAB11FIP1, RCP
Domain Architecture	No domain graphic available
Description	Rab11 family-interacting protein 1 (Rab11-FIP1) (Rab-coupling protein).

EM55_HUMAN
θ value	4.03905 (rank : 32)	NC score	0.010304 (rank : 36)
Query Neighborhood Hits	46	Target Neighborhood Hits	228	Shared Neighborhood Hits	3
SwissProt Accessions	Q00013	Gene names	MPP1, DXS552E, EMP55
Domain Architecture
Description	55 kDa erythrocyte membrane protein (p55) (Membrane protein, palmitoylated 1).

MATN4_MOUSE
θ value	4.03905 (rank : 33)	NC score	0.025712 (rank : 22)
Query Neighborhood Hits	46	Target Neighborhood Hits	277	Shared Neighborhood Hits	14
SwissProt Accessions	O89029, O89030, Q9QWS3	Gene names	Matn4
Domain Architecture
Description	Matrilin-4 precursor (MAT-4).

POLS_MOUSE
θ value	4.03905 (rank : 34)	NC score	0.012466 (rank : 32)
Query Neighborhood Hits	46	Target Neighborhood Hits	91	Shared Neighborhood Hits	2
SwissProt Accessions	Q6PB75	Gene names	Pols
Domain Architecture	No domain graphic available
Description	DNA polymerase sigma (EC 2.7.7.7).

PRRT3_HUMAN
θ value	4.03905 (rank : 35)	NC score	0.014536 (rank : 29)
Query Neighborhood Hits	46	Target Neighborhood Hits	998	Shared Neighborhood Hits	11
SwissProt Accessions	Q5FWE3, Q49AD0, Q6UXY6, Q8NBC9	Gene names	PRRT3, UNQ5823/PRO19642
Domain Architecture	No domain graphic available
Description	Proline-rich transmembrane protein 3.

CN155_HUMAN
θ value	5.27518 (rank : 36)	NC score	0.011310 (rank : 35)
Query Neighborhood Hits	46	Target Neighborhood Hits	385	Shared Neighborhood Hits	5
SwissProt Accessions	Q5H9T9, Q5H9U7, Q86YI2, Q9H0J3	Gene names	C14orf155
Domain Architecture	No domain graphic available
Description	Protein C14orf155.

K1718_MOUSE
θ value	5.27518 (rank : 37)	NC score	0.007495 (rank : 42)
Query Neighborhood Hits	46	Target Neighborhood Hits	98	Shared Neighborhood Hits	2
SwissProt Accessions	Q3UWM4, Q3UWN8, Q6ZPJ5, Q8C969, Q8C9E0, Q91VX8	Gene names	Kiaa1718
Domain Architecture	No domain graphic available
Description	Protein KIAA1718.

RAD18_MOUSE
θ value	5.27518 (rank : 38)	NC score	0.011367 (rank : 34)
Query Neighborhood Hits	46	Target Neighborhood Hits	230	Shared Neighborhood Hits	3
SwissProt Accessions	Q9QXK2, Q9CZB8	Gene names	Rad18, Rad18sc
Domain Architecture
Description	Postreplication repair protein RAD18 (mRAD18Sc).

SUSD4_HUMAN
θ value	5.27518 (rank : 39)	NC score	0.009028 (rank : 40)
Query Neighborhood Hits	46	Target Neighborhood Hits	88	Shared Neighborhood Hits	2
SwissProt Accessions	Q5VX71, Q6UX62, Q9BSR0, Q9NWG0	Gene names	SUSD4
Domain Architecture	No domain graphic available
Description	Sushi domain-containing protein 4 precursor.

BRD4_HUMAN
θ value	6.88961 (rank : 40)	NC score	0.007305 (rank : 43)
Query Neighborhood Hits	46	Target Neighborhood Hits	851	Shared Neighborhood Hits	8
SwissProt Accessions	O60885, O60433, Q96PD3	Gene names	BRD4, HUNK1
Domain Architecture
Description	Bromodomain-containing protein 4 (HUNK1 protein).

BRD4_MOUSE
θ value	6.88961 (rank : 41)	NC score	0.006441 (rank : 44)
Query Neighborhood Hits	46	Target Neighborhood Hits	845	Shared Neighborhood Hits	5
SwissProt Accessions	Q9ESU6, Q8VHF7, Q8VHF8	Gene names	Brd4, Mcap
Domain Architecture	No domain graphic available
Description	Bromodomain-containing protein 4 (Mitotic chromosome-associated protein) (MCAP).

HMCN1_HUMAN
θ value	6.88961 (rank : 42)	NC score	0.001615 (rank : 46)
Query Neighborhood Hits	46	Target Neighborhood Hits	983	Shared Neighborhood Hits	7
SwissProt Accessions	Q96RW7, Q5TYR7, Q96DN3, Q96DN8, Q96SC3	Gene names	HMCN1, FIBL6
Domain Architecture	No domain graphic available
Description	Hemicentin-1 precursor (Fibulin-6) (FIBL-6).

IF35_HUMAN
θ value	6.88961 (rank : 43)	NC score	0.010299 (rank : 37)
Query Neighborhood Hits	46	Target Neighborhood Hits	130	Shared Neighborhood Hits	3
SwissProt Accessions	O00303, Q8N978	Gene names	EIF3S5
Domain Architecture
Description	Eukaryotic translation initiation factor 3 subunit 5 (eIF-3 epsilon) (eIF3 p47 subunit) (eIF3f).

JPH2_HUMAN
θ value	6.88961 (rank : 44)	NC score	0.005972 (rank : 45)
Query Neighborhood Hits	46	Target Neighborhood Hits	639	Shared Neighborhood Hits	9
SwissProt Accessions	Q9BR39, O95913, Q5JY74, Q9UJN4	Gene names	JPH2, JP2
Domain Architecture
Description	Junctophilin-2 (Junctophilin type 2) (JP-2).

ITAX_HUMAN
θ value	8.99809 (rank : 45)	NC score	0.021217 (rank : 24)
Query Neighborhood Hits	46	Target Neighborhood Hits	81	Shared Neighborhood Hits	12
SwissProt Accessions	P20702, Q8IVA6	Gene names	ITGAX, CD11C
Domain Architecture
Description	Integrin alpha-X precursor (Leukocyte adhesion glycoprotein p150,95 alpha chain) (Leukocyte adhesion receptor p150,95) (Leu M5) (CD11c antigen).

SPHK2_HUMAN
θ value	8.99809 (rank : 46)	NC score	0.008853 (rank : 41)
Query Neighborhood Hits	46	Target Neighborhood Hits	81	Shared Neighborhood Hits	3
SwissProt Accessions	Q9NRA0, Q9BRN1, Q9H0Q2, Q9NWU7	Gene names	SPHK2
Domain Architecture
Description	Sphingosine kinase 2 (EC 2.7.1.-) (SK 2) (SPK 2).

Hits sorted by NC score

ITIH4_HUMAN
NC score	0.999962 (rank : 1)	θ value	0 (rank : 1)
Query Neighborhood Hits	46	Target Neighborhood Hits	46	Shared Neighborhood Hits	46
SwissProt Accessions	Q14624, Q15135, Q9P190, Q9UQ54	Gene names	ITIH4, IHRP, ITIHL1, PK120
Domain Architecture
Description	Inter-alpha-trypsin inhibitor heavy chain H4 precursor (ITI heavy chain H4) (Inter-alpha-inhibitor heavy chain 4) (Inter-alpha-trypsin inhibitor family heavy chain-related protein) (IHRP) (Plasma kallikrein sensitive glycoprotein 120) (PK-120) (GP120) [Contains: 70 kDa inter-alpha-trypsin inhibitor heavy chain H4; 35 kDa inter-alpha- trypsin inhibitor heavy chain H4].

ITIH3_HUMAN
NC score	0.971576 (rank : 2)	θ value	1.36511e-173 (rank : 2)
Query Neighborhood Hits	46	Target Neighborhood Hits	38	Shared Neighborhood Hits	14
SwissProt Accessions	Q06033, Q99085	Gene names	ITIH3
Domain Architecture
Description	Inter-alpha-trypsin inhibitor heavy chain H3 precursor (ITI heavy chain H3) (Inter-alpha-inhibitor heavy chain 3) (Serum-derived hyaluronan-associated protein) (SHAP).

ITIH3_MOUSE
NC score	0.971223 (rank : 3)	θ value	5.73535e-172 (rank : 3)
Query Neighborhood Hits	46	Target Neighborhood Hits	34	Shared Neighborhood Hits	16
SwissProt Accessions	Q61704	Gene names	Itih3
Domain Architecture
Description	Inter-alpha-trypsin inhibitor heavy chain H3 precursor (ITI heavy chain H3) (Inter-alpha-inhibitor heavy chain 3).

ITIH1_HUMAN
NC score	0.963784 (rank : 4)	θ value	6.19918e-134 (rank : 6)
Query Neighborhood Hits	46	Target Neighborhood Hits	30	Shared Neighborhood Hits	14
SwissProt Accessions	P19827, P78455, Q01746	Gene names	ITIH1, IGHEP1
Domain Architecture
Description	Inter-alpha-trypsin inhibitor heavy chain H1 precursor (ITI heavy chain H1) (Inter-alpha-inhibitor heavy chain 1) (Inter-alpha-trypsin inhibitor complex component III) (Serum-derived hyaluronan-associated protein) (SHAP).

ITIH1_MOUSE
NC score	0.963252 (rank : 5)	θ value	2.13063e-134 (rank : 5)
Query Neighborhood Hits	46	Target Neighborhood Hits	31	Shared Neighborhood Hits	16
SwissProt Accessions	Q61702	Gene names	Itih1
Domain Architecture
Description	Inter-alpha-trypsin inhibitor heavy chain H1 precursor (ITI heavy chain H1) (Inter-alpha-inhibitor heavy chain 1).

ITIH2_MOUSE
NC score	0.955242 (rank : 6)	θ value	7.57797e-132 (rank : 7)
Query Neighborhood Hits	46	Target Neighborhood Hits	27	Shared Neighborhood Hits	14
SwissProt Accessions	Q61703	Gene names	Itih2
Domain Architecture
Description	Inter-alpha-trypsin inhibitor heavy chain H2 precursor (ITI heavy chain H2) (Inter-alpha-inhibitor heavy chain 2).

ITIH2_HUMAN
NC score	0.952003 (rank : 7)	θ value	2.97304e-136 (rank : 4)
Query Neighborhood Hits	46	Target Neighborhood Hits	29	Shared Neighborhood Hits	10
SwissProt Accessions	P19823, Q14659, Q15484	Gene names	ITIH2, IGHEP2
Domain Architecture
Description	Inter-alpha-trypsin inhibitor heavy chain H2 precursor (ITI heavy chain H2) (Inter-alpha-inhibitor heavy chain 2) (Inter-alpha-trypsin inhibitor complex component II) (Serum-derived hyaluronan-associated protein) (SHAP).

LHR2A_HUMAN
NC score	0.375774 (rank : 8)	θ value	1.47974e-10 (rank : 9)
Query Neighborhood Hits	46	Target Neighborhood Hits	16	Shared Neighborhood Hits	8
SwissProt Accessions	O00534, Q6UN19, Q6UN20, Q9BVF8	Gene names	LOH11CR2A, BCSC1
Domain Architecture
Description	Loss of heterozygosity 11 chromosomal region 2 gene A protein (Breast cancer suppressor candidate 1) (BCSC-1).

LHR2A_MOUSE
NC score	0.352299 (rank : 9)	θ value	8.11959e-09 (rank : 10)
Query Neighborhood Hits	46	Target Neighborhood Hits	16	Shared Neighborhood Hits	9
SwissProt Accessions	Q99KC8, Q3TTU2, Q6UN22, Q8BHA8, Q9CTV9	Gene names	Loh11cr2a
Domain Architecture
Description	Loss of heterozygosity 11 chromosomal region 2 gene A protein homolog.

PARP4_HUMAN
NC score	0.344964 (rank : 10)	θ value	5.08577e-11 (rank : 8)
Query Neighborhood Hits	46	Target Neighborhood Hits	93	Shared Neighborhood Hits	12
SwissProt Accessions	Q9UKK3, O75903, Q14682, Q9H1M6	Gene names	PARP4, ADPRTL1, KIAA0177, PARPL
Domain Architecture
Description	Poly [ADP-ribose] polymerase 4 (EC 2.4.2.30) (PARP-4) (Vault poly(ADP- ribose) polymerase) (VPARP) (193 kDa vault protein) (PARP- related/IalphaI-related H5/proline-rich) (PH5P).

CAC2D_MOUSE
NC score	0.311689 (rank : 11)	θ value	0.000270298 (rank : 12)
Query Neighborhood Hits	46	Target Neighborhood Hits	42	Shared Neighborhood Hits	17
SwissProt Accessions	O08532, O08533, O08534, O08535, O08536	Gene names	Cacna2d1, Cacna2
Domain Architecture
Description	Dihydropyridine-sensitive L-type calcium channel subunits alpha- 2/delta precursor [Contains: L-type calcium channel subunit alpha-2; L-type calcium channel subunit delta].

CAC2D_HUMAN
NC score	0.311470 (rank : 12)	θ value	7.1131e-05 (rank : 11)
Query Neighborhood Hits	46	Target Neighborhood Hits	32	Shared Neighborhood Hits	13
SwissProt Accessions	P54289	Gene names	CACNA2D1, CACNL2A, CCHL2A
Domain Architecture
Description	Dihydropyridine-sensitive L-type calcium channel subunits alpha- 2/delta precursor [Contains: L-type calcium channel subunit alpha-2; L-type calcium channel subunit delta].

ANTR2_MOUSE
NC score	0.088993 (rank : 13)	θ value	0.000461057 (rank : 13)
Query Neighborhood Hits	46	Target Neighborhood Hits	26	Shared Neighborhood Hits	8
SwissProt Accessions	Q6DFX2, Q99L17	Gene names	Antxr2
Domain Architecture	No domain graphic available
Description	Anthrax toxin receptor 2 precursor.

ANTR2_HUMAN
NC score	0.079766 (rank : 14)	θ value	0.00665767 (rank : 14)
Query Neighborhood Hits	46	Target Neighborhood Hits	34	Shared Neighborhood Hits	7
SwissProt Accessions	P58335, Q59E98, Q5JPE9, Q86UI1, Q8N4J8, Q8NB13, Q96NC7	Gene names	ANTXR2, CMG2
Domain Architecture
Description	Anthrax toxin receptor 2 precursor (Capillary morphogenesis gene 2 protein) (CMG-2).

MATN1_MOUSE
NC score	0.059169 (rank : 15)	θ value	0.47712 (rank : 17)
Query Neighborhood Hits	46	Target Neighborhood Hits	186	Shared Neighborhood Hits	17
SwissProt Accessions	P51942	Gene names	Matn1, Cmp, Crtm
Domain Architecture
Description	Cartilage matrix protein precursor (Matrilin-1).

MATN1_HUMAN
NC score	0.052438 (rank : 16)	θ value	1.81305 (rank : 26)
Query Neighborhood Hits	46	Target Neighborhood Hits	191	Shared Neighborhood Hits	17
SwissProt Accessions	P21941	Gene names	MATN1, CMP, CRTM
Domain Architecture
Description	Cartilage matrix protein precursor (Matrilin-1).

CO6A1_MOUSE
NC score	0.039670 (rank : 17)	θ value	0.365318 (rank : 16)
Query Neighborhood Hits	46	Target Neighborhood Hits	241	Shared Neighborhood Hits	14
SwissProt Accessions	Q04857	Gene names	Col6a1
Domain Architecture
Description	Collagen alpha-1(VI) chain precursor.

CO6A1_HUMAN
NC score	0.034466 (rank : 18)	θ value	0.21417 (rank : 15)
Query Neighborhood Hits	46	Target Neighborhood Hits	264	Shared Neighborhood Hits	14
SwissProt Accessions	P12109, O00117, O00118, Q14040, Q14041, Q16258	Gene names	COL6A1
Domain Architecture
Description	Collagen alpha-1(VI) chain precursor.

PRRT3_MOUSE
NC score	0.033362 (rank : 19)	θ value	1.06291 (rank : 20)
Query Neighborhood Hits	46	Target Neighborhood Hits	162	Shared Neighborhood Hits	4
SwissProt Accessions	Q6PE13	Gene names	Prrt3
Domain Architecture	No domain graphic available
Description	Proline-rich transmembrane protein 3.

ITAM_MOUSE
NC score	0.029940 (rank : 20)	θ value	0.813845 (rank : 18)
Query Neighborhood Hits	46	Target Neighborhood Hits	77	Shared Neighborhood Hits	15
SwissProt Accessions	P05555, Q8CA73	Gene names	Itgam
Domain Architecture
Description	Integrin alpha-M precursor (Cell surface glycoprotein MAC-1 alpha subunit) (CR-3 alpha chain) (Leukocyte adhesion receptor MO1) (CD11b antigen).

ITAM_HUMAN
NC score	0.027599 (rank : 21)	θ value	1.81305 (rank : 25)
Query Neighborhood Hits	46	Target Neighborhood Hits	78	Shared Neighborhood Hits	12
SwissProt Accessions	P11215	Gene names	ITGAM, CD11B, CR3A
Domain Architecture
Description	Integrin alpha-M precursor (Cell surface glycoprotein MAC-1 alpha subunit) (CR-3 alpha chain) (Leukocyte adhesion receptor MO1) (Neutrophil adherence receptor) (CD11b antigen).

MATN4_MOUSE
NC score	0.025712 (rank : 22)	θ value	4.03905 (rank : 33)
Query Neighborhood Hits	46	Target Neighborhood Hits	277	Shared Neighborhood Hits	14
SwissProt Accessions	O89029, O89030, Q9QWS3	Gene names	Matn4
Domain Architecture
Description	Matrilin-4 precursor (MAT-4).

CAYP2_HUMAN
NC score	0.022343 (rank : 23)	θ value	1.81305 (rank : 22)
Query Neighborhood Hits	46	Target Neighborhood Hits	98	Shared Neighborhood Hits	2
SwissProt Accessions	Q9BXY5, Q6PH84, Q8N242, Q8NAY5	Gene names	CAPS2
Domain Architecture
Description	Calcyphosin-2 (Calcyphosine-2).

ITAX_HUMAN
NC score	0.021217 (rank : 24)	θ value	8.99809 (rank : 45)
Query Neighborhood Hits	46	Target Neighborhood Hits	81	Shared Neighborhood Hits	12
SwissProt Accessions	P20702, Q8IVA6	Gene names	ITGAX, CD11C
Domain Architecture
Description	Integrin alpha-X precursor (Leukocyte adhesion glycoprotein p150,95 alpha chain) (Leukocyte adhesion receptor p150,95) (Leu M5) (CD11c antigen).

MATN4_HUMAN
NC score	0.020906 (rank : 25)	θ value	2.36792 (rank : 28)
Query Neighborhood Hits	46	Target Neighborhood Hits	287	Shared Neighborhood Hits	12
SwissProt Accessions	O95460, Q5QPU2, Q5QPU3, Q5QPU4, Q8N2M5, Q8N2M7, Q9H1F8, Q9H1F9	Gene names	MATN4
Domain Architecture
Description	Matrilin-4 precursor.

FCGR1_MOUSE
NC score	0.016805 (rank : 26)	θ value	1.06291 (rank : 19)
Query Neighborhood Hits	46	Target Neighborhood Hits	123	Shared Neighborhood Hits	3
SwissProt Accessions	P26151	Gene names	Fcgr1, Fcg1
Domain Architecture
Description	High affinity immunoglobulin gamma Fc receptor I precursor (Fc-gamma RI) (FcRI) (IgG Fc receptor I).

FLNA_MOUSE
NC score	0.016477 (rank : 27)	θ value	1.38821 (rank : 21)
Query Neighborhood Hits	46	Target Neighborhood Hits	142	Shared Neighborhood Hits	4
SwissProt Accessions	Q8BTM8, O54934, Q7TQI1, Q8BLK1, Q8BTN7, Q8VHX5, Q8VHX8, Q99KQ2	Gene names	Flna, Fln, Fln1
Domain Architecture
Description	Filamin-A (Alpha-filamin) (Filamin-1) (Endothelial actin-binding protein) (Actin-binding protein 280) (ABP-280) (Nonmuscle filamin).

FLNA_HUMAN
NC score	0.016121 (rank : 28)	θ value	1.81305 (rank : 23)
Query Neighborhood Hits	46	Target Neighborhood Hits	138	Shared Neighborhood Hits	4
SwissProt Accessions	P21333	Gene names	FLNA, FLN, FLN1
Domain Architecture
Description	Filamin-A (Alpha-filamin) (Filamin-1) (Endothelial actin-binding protein) (Actin-binding protein 280) (ABP-280) (Nonmuscle filamin).

PRRT3_HUMAN
NC score	0.014536 (rank : 29)	θ value	4.03905 (rank : 35)
Query Neighborhood Hits	46	Target Neighborhood Hits	998	Shared Neighborhood Hits	11
SwissProt Accessions	Q5FWE3, Q49AD0, Q6UXY6, Q8NBC9	Gene names	PRRT3, UNQ5823/PRO19642
Domain Architecture	No domain graphic available
Description	Proline-rich transmembrane protein 3.

RFIP1_HUMAN
NC score	0.014191 (rank : 30)	θ value	3.0926 (rank : 31)
Query Neighborhood Hits	46	Target Neighborhood Hits	236	Shared Neighborhood Hits	4
SwissProt Accessions	Q6WKZ4, Q6AZK4, Q6WKZ2, Q6WKZ6, Q86YV4, Q8TDL1, Q9H642	Gene names	RAB11FIP1, RCP
Domain Architecture	No domain graphic available
Description	Rab11 family-interacting protein 1 (Rab11-FIP1) (Rab-coupling protein).

GNDS_HUMAN
NC score	0.013456 (rank : 31)	θ value	1.81305 (rank : 24)
Query Neighborhood Hits	46	Target Neighborhood Hits	201	Shared Neighborhood Hits	4
SwissProt Accessions	Q12967, Q9HAX7, Q9HAY1, Q9HCT1	Gene names	RALGDS, RGF
Domain Architecture
Description	Ral guanine nucleotide dissociation stimulator (RalGEF) (RalGDS).

POLS_MOUSE
NC score	0.012466 (rank : 32)	θ value	4.03905 (rank : 34)
Query Neighborhood Hits	46	Target Neighborhood Hits	91	Shared Neighborhood Hits	2
SwissProt Accessions	Q6PB75	Gene names	Pols
Domain Architecture	No domain graphic available
Description	DNA polymerase sigma (EC 2.7.7.7).

EM55_MOUSE
NC score	0.011454 (rank : 33)	θ value	2.36792 (rank : 27)
Query Neighborhood Hits	46	Target Neighborhood Hits	221	Shared Neighborhood Hits	3
SwissProt Accessions	P70290	Gene names	Mpp1
Domain Architecture
Description	55 kDa erythrocyte membrane protein (p55) (Membrane protein, palmitoylated 1) (Palmitoylated protein p55).

RAD18_MOUSE
NC score	0.011367 (rank : 34)	θ value	5.27518 (rank : 38)
Query Neighborhood Hits	46	Target Neighborhood Hits	230	Shared Neighborhood Hits	3
SwissProt Accessions	Q9QXK2, Q9CZB8	Gene names	Rad18, Rad18sc
Domain Architecture
Description	Postreplication repair protein RAD18 (mRAD18Sc).

CN155_HUMAN
NC score	0.011310 (rank : 35)	θ value	5.27518 (rank : 36)
Query Neighborhood Hits	46	Target Neighborhood Hits	385	Shared Neighborhood Hits	5
SwissProt Accessions	Q5H9T9, Q5H9U7, Q86YI2, Q9H0J3	Gene names	C14orf155
Domain Architecture	No domain graphic available
Description	Protein C14orf155.

EM55_HUMAN
NC score	0.010304 (rank : 36)	θ value	4.03905 (rank : 32)
Query Neighborhood Hits	46	Target Neighborhood Hits	228	Shared Neighborhood Hits	3
SwissProt Accessions	Q00013	Gene names	MPP1, DXS552E, EMP55
Domain Architecture
Description	55 kDa erythrocyte membrane protein (p55) (Membrane protein, palmitoylated 1).

IF35_HUMAN
NC score	0.010299 (rank : 37)	θ value	6.88961 (rank : 43)
Query Neighborhood Hits	46	Target Neighborhood Hits	130	Shared Neighborhood Hits	3
SwissProt Accessions	O00303, Q8N978	Gene names	EIF3S5
Domain Architecture
Description	Eukaryotic translation initiation factor 3 subunit 5 (eIF-3 epsilon) (eIF3 p47 subunit) (eIF3f).

PABP1_HUMAN
NC score	0.009654 (rank : 38)	θ value	3.0926 (rank : 29)
Query Neighborhood Hits	46	Target Neighborhood Hits	269	Shared Neighborhood Hits	4
SwissProt Accessions	P11940, Q15097, Q93004	Gene names	PABPC1, PAB1, PABP1, PABPC2
Domain Architecture
Description	Polyadenylate-binding protein 1 (Poly(A)-binding protein 1) (PABP 1).

PABP1_MOUSE
NC score	0.009633 (rank : 39)	θ value	3.0926 (rank : 30)
Query Neighborhood Hits	46	Target Neighborhood Hits	278	Shared Neighborhood Hits	4
SwissProt Accessions	P29341	Gene names	Pabpc1, Pabp1
Domain Architecture
Description	Polyadenylate-binding protein 1 (Poly(A)-binding protein 1) (PABP 1).

SUSD4_HUMAN
NC score	0.009028 (rank : 40)	θ value	5.27518 (rank : 39)
Query Neighborhood Hits	46	Target Neighborhood Hits	88	Shared Neighborhood Hits	2
SwissProt Accessions	Q5VX71, Q6UX62, Q9BSR0, Q9NWG0	Gene names	SUSD4
Domain Architecture	No domain graphic available
Description	Sushi domain-containing protein 4 precursor.

SPHK2_HUMAN
NC score	0.008853 (rank : 41)	θ value	8.99809 (rank : 46)
Query Neighborhood Hits	46	Target Neighborhood Hits	81	Shared Neighborhood Hits	3
SwissProt Accessions	Q9NRA0, Q9BRN1, Q9H0Q2, Q9NWU7	Gene names	SPHK2
Domain Architecture
Description	Sphingosine kinase 2 (EC 2.7.1.-) (SK 2) (SPK 2).

K1718_MOUSE
NC score	0.007495 (rank : 42)	θ value	5.27518 (rank : 37)
Query Neighborhood Hits	46	Target Neighborhood Hits	98	Shared Neighborhood Hits	2
SwissProt Accessions	Q3UWM4, Q3UWN8, Q6ZPJ5, Q8C969, Q8C9E0, Q91VX8	Gene names	Kiaa1718
Domain Architecture	No domain graphic available
Description	Protein KIAA1718.

BRD4_HUMAN
NC score	0.007305 (rank : 43)	θ value	6.88961 (rank : 40)
Query Neighborhood Hits	46	Target Neighborhood Hits	851	Shared Neighborhood Hits	8
SwissProt Accessions	O60885, O60433, Q96PD3	Gene names	BRD4, HUNK1
Domain Architecture
Description	Bromodomain-containing protein 4 (HUNK1 protein).

BRD4_MOUSE
NC score	0.006441 (rank : 44)	θ value	6.88961 (rank : 41)
Query Neighborhood Hits	46	Target Neighborhood Hits	845	Shared Neighborhood Hits	5
SwissProt Accessions	Q9ESU6, Q8VHF7, Q8VHF8	Gene names	Brd4, Mcap
Domain Architecture	No domain graphic available
Description	Bromodomain-containing protein 4 (Mitotic chromosome-associated protein) (MCAP).

JPH2_HUMAN
NC score	0.005972 (rank : 45)	θ value	6.88961 (rank : 44)
Query Neighborhood Hits	46	Target Neighborhood Hits	639	Shared Neighborhood Hits	9
SwissProt Accessions	Q9BR39, O95913, Q5JY74, Q9UJN4	Gene names	JPH2, JP2
Domain Architecture
Description	Junctophilin-2 (Junctophilin type 2) (JP-2).

HMCN1_HUMAN
NC score	0.001615 (rank : 46)	θ value	6.88961 (rank : 42)
Query Neighborhood Hits	46	Target Neighborhood Hits	983	Shared Neighborhood Hits	7
SwissProt Accessions	Q96RW7, Q5TYR7, Q96DN3, Q96DN8, Q96SC3	Gene names	HMCN1, FIBL6
Domain Architecture	No domain graphic available
Description	Hemicentin-1 precursor (Fibulin-6) (FIBL-6).