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Network neighborhood for query Sequence : LHR2A_HUMAN

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LHR2A_HUMAN
SwissProt Accessions	O00534, Q6UN19, Q6UN20, Q9BVF8	Gene names	LOH11CR2A, BCSC1
Domain Architecture
Description	Loss of heterozygosity 11 chromosomal region 2 gene A protein (Breast cancer suppressor candidate 1) (BCSC-1).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

LHR2A_HUMAN
θ value	0 (rank : 1)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	16	Target Neighborhood Hits	16	Shared Neighborhood Hits	16
SwissProt Accessions	O00534, Q6UN19, Q6UN20, Q9BVF8	Gene names	LOH11CR2A, BCSC1
Domain Architecture
Description	Loss of heterozygosity 11 chromosomal region 2 gene A protein (Breast cancer suppressor candidate 1) (BCSC-1).

LHR2A_MOUSE
θ value	0 (rank : 2)	NC score	0.989424 (rank : 2)
Query Neighborhood Hits	16	Target Neighborhood Hits	16	Shared Neighborhood Hits	8
SwissProt Accessions	Q99KC8, Q3TTU2, Q6UN22, Q8BHA8, Q9CTV9	Gene names	Loh11cr2a
Domain Architecture
Description	Loss of heterozygosity 11 chromosomal region 2 gene A protein homolog.

PARP4_HUMAN
θ value	5.76516e-39 (rank : 3)	NC score	0.630753 (rank : 3)
Query Neighborhood Hits	16	Target Neighborhood Hits	93	Shared Neighborhood Hits	8
SwissProt Accessions	Q9UKK3, O75903, Q14682, Q9H1M6	Gene names	PARP4, ADPRTL1, KIAA0177, PARPL
Domain Architecture
Description	Poly [ADP-ribose] polymerase 4 (EC 2.4.2.30) (PARP-4) (Vault poly(ADP- ribose) polymerase) (VPARP) (193 kDa vault protein) (PARP- related/IalphaI-related H5/proline-rich) (PH5P).

ITIH1_HUMAN
θ value	3.89403e-11 (rank : 4)	NC score	0.344635 (rank : 5)
Query Neighborhood Hits	16	Target Neighborhood Hits	30	Shared Neighborhood Hits	8
SwissProt Accessions	P19827, P78455, Q01746	Gene names	ITIH1, IGHEP1
Domain Architecture
Description	Inter-alpha-trypsin inhibitor heavy chain H1 precursor (ITI heavy chain H1) (Inter-alpha-inhibitor heavy chain 1) (Inter-alpha-trypsin inhibitor complex component III) (Serum-derived hyaluronan-associated protein) (SHAP).

ITIH4_HUMAN
θ value	1.47974e-10 (rank : 5)	NC score	0.375774 (rank : 4)
Query Neighborhood Hits	16	Target Neighborhood Hits	46	Shared Neighborhood Hits	8
SwissProt Accessions	Q14624, Q15135, Q9P190, Q9UQ54	Gene names	ITIH4, IHRP, ITIHL1, PK120
Domain Architecture
Description	Inter-alpha-trypsin inhibitor heavy chain H4 precursor (ITI heavy chain H4) (Inter-alpha-inhibitor heavy chain 4) (Inter-alpha-trypsin inhibitor family heavy chain-related protein) (IHRP) (Plasma kallikrein sensitive glycoprotein 120) (PK-120) (GP120) [Contains: 70 kDa inter-alpha-trypsin inhibitor heavy chain H4; 35 kDa inter-alpha- trypsin inhibitor heavy chain H4].

ITIH1_MOUSE
θ value	1.99992e-07 (rank : 6)	NC score	0.312691 (rank : 6)
Query Neighborhood Hits	16	Target Neighborhood Hits	31	Shared Neighborhood Hits	8
SwissProt Accessions	Q61702	Gene names	Itih1
Domain Architecture
Description	Inter-alpha-trypsin inhibitor heavy chain H1 precursor (ITI heavy chain H1) (Inter-alpha-inhibitor heavy chain 1).

ITIH3_HUMAN
θ value	1.87187e-05 (rank : 7)	NC score	0.306928 (rank : 7)
Query Neighborhood Hits	16	Target Neighborhood Hits	38	Shared Neighborhood Hits	8
SwissProt Accessions	Q06033, Q99085	Gene names	ITIH3
Domain Architecture
Description	Inter-alpha-trypsin inhibitor heavy chain H3 precursor (ITI heavy chain H3) (Inter-alpha-inhibitor heavy chain 3) (Serum-derived hyaluronan-associated protein) (SHAP).

ITIH3_MOUSE
θ value	9.29e-05 (rank : 8)	NC score	0.299780 (rank : 8)
Query Neighborhood Hits	16	Target Neighborhood Hits	34	Shared Neighborhood Hits	8
SwissProt Accessions	Q61704	Gene names	Itih3
Domain Architecture
Description	Inter-alpha-trypsin inhibitor heavy chain H3 precursor (ITI heavy chain H3) (Inter-alpha-inhibitor heavy chain 3).

TOP2A_HUMAN
θ value	0.62314 (rank : 9)	NC score	0.028585 (rank : 20)
Query Neighborhood Hits	16	Target Neighborhood Hits	135	Shared Neighborhood Hits	2
SwissProt Accessions	P11388, Q71UN1, Q9HB24, Q9HB25, Q9HB26, Q9UP44, Q9UQP9	Gene names	TOP2A, TOP2
Domain Architecture
Description	DNA topoisomerase 2-alpha (EC 5.99.1.3) (DNA topoisomerase II, alpha isozyme).

CASC5_MOUSE
θ value	1.38821 (rank : 10)	NC score	0.034526 (rank : 18)
Query Neighborhood Hits	16	Target Neighborhood Hits	70	Shared Neighborhood Hits	2
SwissProt Accessions	Q66JQ7, Q8CCH6, Q9CV38	Gene names	Casc5
Domain Architecture	No domain graphic available
Description	Protein CASC5 (Cancer susceptibility candidate gene 5 protein homolog).

PTHB1_MOUSE
θ value	1.38821 (rank : 11)	NC score	0.034107 (rank : 19)
Query Neighborhood Hits	16	Target Neighborhood Hits	11	Shared Neighborhood Hits	2
SwissProt Accessions	Q811G0, P97498, Q3UMR2, Q7TQH9, Q8BKD7, Q8K0T5	Gene names	Pthb1
Domain Architecture	No domain graphic available
Description	Protein PTHB1 (Parathyroid hormone-responsive B1 gene protein homolog).

EGR3_HUMAN
θ value	3.0926 (rank : 12)	NC score	0.004116 (rank : 24)
Query Neighborhood Hits	16	Target Neighborhood Hits	746	Shared Neighborhood Hits	3
SwissProt Accessions	Q06889	Gene names	EGR3, PILOT
Domain Architecture	No domain graphic available
Description	Early growth response protein 3 (EGR-3) (Zinc finger protein pilot).

EGR3_MOUSE
θ value	5.27518 (rank : 13)	NC score	0.003535 (rank : 25)
Query Neighborhood Hits	16	Target Neighborhood Hits	747	Shared Neighborhood Hits	3
SwissProt Accessions	P43300, Q9R276	Gene names	Egr3, Egr-3
Domain Architecture
Description	Early growth response protein 3 (EGR-3).

MDR1_HUMAN
θ value	6.88961 (rank : 14)	NC score	0.005007 (rank : 23)
Query Neighborhood Hits	16	Target Neighborhood Hits	112	Shared Neighborhood Hits	2
SwissProt Accessions	P08183, Q12755, Q14812	Gene names	ABCB1, MDR1, PGY1
Domain Architecture
Description	Multidrug resistance protein 1 (EC 3.6.3.44) (ATP-binding cassette sub-family B member 1) (P-glycoprotein 1) (CD243 antigen).

AYT1B_MOUSE
θ value	8.99809 (rank : 15)	NC score	0.010791 (rank : 21)
Query Neighborhood Hits	16	Target Neighborhood Hits	113	Shared Neighborhood Hits	3
SwissProt Accessions	Q9D5U0	Gene names	Aytl1b
Domain Architecture	No domain graphic available
Description	Acyltransferase-like 1-B (EC 2.3.1.-).

AYTL1_HUMAN
θ value	8.99809 (rank : 16)	NC score	0.010427 (rank : 22)
Query Neighborhood Hits	16	Target Neighborhood Hits	140	Shared Neighborhood Hits	3
SwissProt Accessions	Q7L5N7, Q6MZJ6, Q9NX23	Gene names	AYTL1
Domain Architecture	No domain graphic available
Description	Acyltransferase-like 1 (EC 2.3.1.-).

CAC2D_HUMAN
θ value	θ > 10 (rank : 17)	NC score	0.055041 (rank : 12)
Query Neighborhood Hits	16	Target Neighborhood Hits	32	Shared Neighborhood Hits	6
SwissProt Accessions	P54289	Gene names	CACNA2D1, CACNL2A, CCHL2A
Domain Architecture
Description	Dihydropyridine-sensitive L-type calcium channel subunits alpha- 2/delta precursor [Contains: L-type calcium channel subunit alpha-2; L-type calcium channel subunit delta].

CAC2D_MOUSE
θ value	θ > 10 (rank : 18)	NC score	0.054753 (rank : 13)
Query Neighborhood Hits	16	Target Neighborhood Hits	42	Shared Neighborhood Hits	6
SwissProt Accessions	O08532, O08533, O08534, O08535, O08536	Gene names	Cacna2d1, Cacna2
Domain Architecture
Description	Dihydropyridine-sensitive L-type calcium channel subunits alpha- 2/delta precursor [Contains: L-type calcium channel subunit alpha-2; L-type calcium channel subunit delta].

ITIH2_HUMAN
θ value	θ > 10 (rank : 19)	NC score	0.205624 (rank : 10)
Query Neighborhood Hits	16	Target Neighborhood Hits	29	Shared Neighborhood Hits	6
SwissProt Accessions	P19823, Q14659, Q15484	Gene names	ITIH2, IGHEP2
Domain Architecture
Description	Inter-alpha-trypsin inhibitor heavy chain H2 precursor (ITI heavy chain H2) (Inter-alpha-inhibitor heavy chain 2) (Inter-alpha-trypsin inhibitor complex component II) (Serum-derived hyaluronan-associated protein) (SHAP).

ITIH2_MOUSE
θ value	θ > 10 (rank : 20)	NC score	0.233689 (rank : 9)
Query Neighborhood Hits	16	Target Neighborhood Hits	27	Shared Neighborhood Hits	7
SwissProt Accessions	Q61703	Gene names	Itih2
Domain Architecture
Description	Inter-alpha-trypsin inhibitor heavy chain H2 precursor (ITI heavy chain H2) (Inter-alpha-inhibitor heavy chain 2).

PARP1_HUMAN
θ value	θ > 10 (rank : 21)	NC score	0.053460 (rank : 14)
Query Neighborhood Hits	16	Target Neighborhood Hits	54	Shared Neighborhood Hits	1
SwissProt Accessions	P09874, Q8IUZ9	Gene names	PARP1, ADPRT, PPOL
Domain Architecture
Description	Poly [ADP-ribose] polymerase 1 (EC 2.4.2.30) (PARP-1) (ADPRT) (NAD(+) ADP-ribosyltransferase 1) (Poly[ADP-ribose] synthetase 1).

PARP1_MOUSE
θ value	θ > 10 (rank : 22)	NC score	0.051535 (rank : 15)
Query Neighborhood Hits	16	Target Neighborhood Hits	102	Shared Neighborhood Hits	1
SwissProt Accessions	P11103, Q9JLX4, Q9QVQ3	Gene names	Parp1, Adprp, Adprt, Adprt1
Domain Architecture
Description	Poly [ADP-ribose] polymerase 1 (EC 2.4.2.30) (PARP-1) (ADPRT) (NAD(+) ADP-ribosyltransferase 1) (Poly[ADP-ribose] synthetase 1) (msPARP).

PARP2_HUMAN
θ value	θ > 10 (rank : 23)	NC score	0.055724 (rank : 11)
Query Neighborhood Hits	16	Target Neighborhood Hits	33	Shared Neighborhood Hits	1
SwissProt Accessions	Q9UGN5, Q8TEU4, Q9NUV2, Q9UMR4, Q9Y6C8	Gene names	PARP2, ADPRT2, ADPRTL2
Domain Architecture
Description	Poly [ADP-ribose] polymerase 2 (EC 2.4.2.30) (PARP-2) (NAD(+) ADP- ribosyltransferase 2) (Poly[ADP-ribose] synthetase 2) (pADPRT-2) (hPARP-2).

PARP2_MOUSE
θ value	θ > 10 (rank : 24)	NC score	0.050838 (rank : 16)
Query Neighborhood Hits	16	Target Neighborhood Hits	53	Shared Neighborhood Hits	1
SwissProt Accessions	O88554, Q99N29	Gene names	Parp2, Adprt2, Adprtl2, Aspartl2
Domain Architecture
Description	Poly [ADP-ribose] polymerase 2 (EC 2.4.2.30) (PARP-2) (NAD(+) ADP- ribosyltransferase 2) (Poly[ADP-ribose] synthetase 2) (pADPRT-2) (mPARP-2).

PARP3_HUMAN
θ value	θ > 10 (rank : 25)	NC score	0.050013 (rank : 17)
Query Neighborhood Hits	16	Target Neighborhood Hits	30	Shared Neighborhood Hits	1
SwissProt Accessions	Q9Y6F1, Q8NER9, Q96CG2, Q9UG81	Gene names	PARP3, ADPRT3, ADPRTL3
Domain Architecture
Description	Poly [ADP-ribose] polymerase 3 (EC 2.4.2.30) (PARP-3) (NAD(+) ADP- ribosyltransferase 3) (Poly[ADP-ribose] synthetase 3) (pADPRT-3) (hPARP-3) (IRT1).

Hits sorted by NC score

LHR2A_HUMAN
NC score	0.999962 (rank : 1)	θ value	0 (rank : 1)
Query Neighborhood Hits	16	Target Neighborhood Hits	16	Shared Neighborhood Hits	16
SwissProt Accessions	O00534, Q6UN19, Q6UN20, Q9BVF8	Gene names	LOH11CR2A, BCSC1
Domain Architecture
Description	Loss of heterozygosity 11 chromosomal region 2 gene A protein (Breast cancer suppressor candidate 1) (BCSC-1).

LHR2A_MOUSE
NC score	0.989424 (rank : 2)	θ value	0 (rank : 2)
Query Neighborhood Hits	16	Target Neighborhood Hits	16	Shared Neighborhood Hits	8
SwissProt Accessions	Q99KC8, Q3TTU2, Q6UN22, Q8BHA8, Q9CTV9	Gene names	Loh11cr2a
Domain Architecture
Description	Loss of heterozygosity 11 chromosomal region 2 gene A protein homolog.

PARP4_HUMAN
NC score	0.630753 (rank : 3)	θ value	5.76516e-39 (rank : 3)
Query Neighborhood Hits	16	Target Neighborhood Hits	93	Shared Neighborhood Hits	8
SwissProt Accessions	Q9UKK3, O75903, Q14682, Q9H1M6	Gene names	PARP4, ADPRTL1, KIAA0177, PARPL
Domain Architecture
Description	Poly [ADP-ribose] polymerase 4 (EC 2.4.2.30) (PARP-4) (Vault poly(ADP- ribose) polymerase) (VPARP) (193 kDa vault protein) (PARP- related/IalphaI-related H5/proline-rich) (PH5P).

ITIH4_HUMAN
NC score	0.375774 (rank : 4)	θ value	1.47974e-10 (rank : 5)
Query Neighborhood Hits	16	Target Neighborhood Hits	46	Shared Neighborhood Hits	8
SwissProt Accessions	Q14624, Q15135, Q9P190, Q9UQ54	Gene names	ITIH4, IHRP, ITIHL1, PK120
Domain Architecture
Description	Inter-alpha-trypsin inhibitor heavy chain H4 precursor (ITI heavy chain H4) (Inter-alpha-inhibitor heavy chain 4) (Inter-alpha-trypsin inhibitor family heavy chain-related protein) (IHRP) (Plasma kallikrein sensitive glycoprotein 120) (PK-120) (GP120) [Contains: 70 kDa inter-alpha-trypsin inhibitor heavy chain H4; 35 kDa inter-alpha- trypsin inhibitor heavy chain H4].

ITIH1_HUMAN
NC score	0.344635 (rank : 5)	θ value	3.89403e-11 (rank : 4)
Query Neighborhood Hits	16	Target Neighborhood Hits	30	Shared Neighborhood Hits	8
SwissProt Accessions	P19827, P78455, Q01746	Gene names	ITIH1, IGHEP1
Domain Architecture
Description	Inter-alpha-trypsin inhibitor heavy chain H1 precursor (ITI heavy chain H1) (Inter-alpha-inhibitor heavy chain 1) (Inter-alpha-trypsin inhibitor complex component III) (Serum-derived hyaluronan-associated protein) (SHAP).

ITIH1_MOUSE
NC score	0.312691 (rank : 6)	θ value	1.99992e-07 (rank : 6)
Query Neighborhood Hits	16	Target Neighborhood Hits	31	Shared Neighborhood Hits	8
SwissProt Accessions	Q61702	Gene names	Itih1
Domain Architecture
Description	Inter-alpha-trypsin inhibitor heavy chain H1 precursor (ITI heavy chain H1) (Inter-alpha-inhibitor heavy chain 1).

ITIH3_HUMAN
NC score	0.306928 (rank : 7)	θ value	1.87187e-05 (rank : 7)
Query Neighborhood Hits	16	Target Neighborhood Hits	38	Shared Neighborhood Hits	8
SwissProt Accessions	Q06033, Q99085	Gene names	ITIH3
Domain Architecture
Description	Inter-alpha-trypsin inhibitor heavy chain H3 precursor (ITI heavy chain H3) (Inter-alpha-inhibitor heavy chain 3) (Serum-derived hyaluronan-associated protein) (SHAP).

ITIH3_MOUSE
NC score	0.299780 (rank : 8)	θ value	9.29e-05 (rank : 8)
Query Neighborhood Hits	16	Target Neighborhood Hits	34	Shared Neighborhood Hits	8
SwissProt Accessions	Q61704	Gene names	Itih3
Domain Architecture
Description	Inter-alpha-trypsin inhibitor heavy chain H3 precursor (ITI heavy chain H3) (Inter-alpha-inhibitor heavy chain 3).

ITIH2_MOUSE
NC score	0.233689 (rank : 9)	θ value	θ > 10 (rank : 20)
Query Neighborhood Hits	16	Target Neighborhood Hits	27	Shared Neighborhood Hits	7
SwissProt Accessions	Q61703	Gene names	Itih2
Domain Architecture
Description	Inter-alpha-trypsin inhibitor heavy chain H2 precursor (ITI heavy chain H2) (Inter-alpha-inhibitor heavy chain 2).

ITIH2_HUMAN
NC score	0.205624 (rank : 10)	θ value	θ > 10 (rank : 19)
Query Neighborhood Hits	16	Target Neighborhood Hits	29	Shared Neighborhood Hits	6
SwissProt Accessions	P19823, Q14659, Q15484	Gene names	ITIH2, IGHEP2
Domain Architecture
Description	Inter-alpha-trypsin inhibitor heavy chain H2 precursor (ITI heavy chain H2) (Inter-alpha-inhibitor heavy chain 2) (Inter-alpha-trypsin inhibitor complex component II) (Serum-derived hyaluronan-associated protein) (SHAP).

PARP2_HUMAN
NC score	0.055724 (rank : 11)	θ value	θ > 10 (rank : 23)
Query Neighborhood Hits	16	Target Neighborhood Hits	33	Shared Neighborhood Hits	1
SwissProt Accessions	Q9UGN5, Q8TEU4, Q9NUV2, Q9UMR4, Q9Y6C8	Gene names	PARP2, ADPRT2, ADPRTL2
Domain Architecture
Description	Poly [ADP-ribose] polymerase 2 (EC 2.4.2.30) (PARP-2) (NAD(+) ADP- ribosyltransferase 2) (Poly[ADP-ribose] synthetase 2) (pADPRT-2) (hPARP-2).

CAC2D_HUMAN
NC score	0.055041 (rank : 12)	θ value	θ > 10 (rank : 17)
Query Neighborhood Hits	16	Target Neighborhood Hits	32	Shared Neighborhood Hits	6
SwissProt Accessions	P54289	Gene names	CACNA2D1, CACNL2A, CCHL2A
Domain Architecture
Description	Dihydropyridine-sensitive L-type calcium channel subunits alpha- 2/delta precursor [Contains: L-type calcium channel subunit alpha-2; L-type calcium channel subunit delta].

CAC2D_MOUSE
NC score	0.054753 (rank : 13)	θ value	θ > 10 (rank : 18)
Query Neighborhood Hits	16	Target Neighborhood Hits	42	Shared Neighborhood Hits	6
SwissProt Accessions	O08532, O08533, O08534, O08535, O08536	Gene names	Cacna2d1, Cacna2
Domain Architecture
Description	Dihydropyridine-sensitive L-type calcium channel subunits alpha- 2/delta precursor [Contains: L-type calcium channel subunit alpha-2; L-type calcium channel subunit delta].

PARP1_HUMAN
NC score	0.053460 (rank : 14)	θ value	θ > 10 (rank : 21)
Query Neighborhood Hits	16	Target Neighborhood Hits	54	Shared Neighborhood Hits	1
SwissProt Accessions	P09874, Q8IUZ9	Gene names	PARP1, ADPRT, PPOL
Domain Architecture
Description	Poly [ADP-ribose] polymerase 1 (EC 2.4.2.30) (PARP-1) (ADPRT) (NAD(+) ADP-ribosyltransferase 1) (Poly[ADP-ribose] synthetase 1).

PARP1_MOUSE
NC score	0.051535 (rank : 15)	θ value	θ > 10 (rank : 22)
Query Neighborhood Hits	16	Target Neighborhood Hits	102	Shared Neighborhood Hits	1
SwissProt Accessions	P11103, Q9JLX4, Q9QVQ3	Gene names	Parp1, Adprp, Adprt, Adprt1
Domain Architecture
Description	Poly [ADP-ribose] polymerase 1 (EC 2.4.2.30) (PARP-1) (ADPRT) (NAD(+) ADP-ribosyltransferase 1) (Poly[ADP-ribose] synthetase 1) (msPARP).

PARP2_MOUSE
NC score	0.050838 (rank : 16)	θ value	θ > 10 (rank : 24)
Query Neighborhood Hits	16	Target Neighborhood Hits	53	Shared Neighborhood Hits	1
SwissProt Accessions	O88554, Q99N29	Gene names	Parp2, Adprt2, Adprtl2, Aspartl2
Domain Architecture
Description	Poly [ADP-ribose] polymerase 2 (EC 2.4.2.30) (PARP-2) (NAD(+) ADP- ribosyltransferase 2) (Poly[ADP-ribose] synthetase 2) (pADPRT-2) (mPARP-2).

PARP3_HUMAN
NC score	0.050013 (rank : 17)	θ value	θ > 10 (rank : 25)
Query Neighborhood Hits	16	Target Neighborhood Hits	30	Shared Neighborhood Hits	1
SwissProt Accessions	Q9Y6F1, Q8NER9, Q96CG2, Q9UG81	Gene names	PARP3, ADPRT3, ADPRTL3
Domain Architecture
Description	Poly [ADP-ribose] polymerase 3 (EC 2.4.2.30) (PARP-3) (NAD(+) ADP- ribosyltransferase 3) (Poly[ADP-ribose] synthetase 3) (pADPRT-3) (hPARP-3) (IRT1).

CASC5_MOUSE
NC score	0.034526 (rank : 18)	θ value	1.38821 (rank : 10)
Query Neighborhood Hits	16	Target Neighborhood Hits	70	Shared Neighborhood Hits	2
SwissProt Accessions	Q66JQ7, Q8CCH6, Q9CV38	Gene names	Casc5
Domain Architecture	No domain graphic available
Description	Protein CASC5 (Cancer susceptibility candidate gene 5 protein homolog).

PTHB1_MOUSE
NC score	0.034107 (rank : 19)	θ value	1.38821 (rank : 11)
Query Neighborhood Hits	16	Target Neighborhood Hits	11	Shared Neighborhood Hits	2
SwissProt Accessions	Q811G0, P97498, Q3UMR2, Q7TQH9, Q8BKD7, Q8K0T5	Gene names	Pthb1
Domain Architecture	No domain graphic available
Description	Protein PTHB1 (Parathyroid hormone-responsive B1 gene protein homolog).

TOP2A_HUMAN
NC score	0.028585 (rank : 20)	θ value	0.62314 (rank : 9)
Query Neighborhood Hits	16	Target Neighborhood Hits	135	Shared Neighborhood Hits	2
SwissProt Accessions	P11388, Q71UN1, Q9HB24, Q9HB25, Q9HB26, Q9UP44, Q9UQP9	Gene names	TOP2A, TOP2
Domain Architecture
Description	DNA topoisomerase 2-alpha (EC 5.99.1.3) (DNA topoisomerase II, alpha isozyme).

AYT1B_MOUSE
NC score	0.010791 (rank : 21)	θ value	8.99809 (rank : 15)
Query Neighborhood Hits	16	Target Neighborhood Hits	113	Shared Neighborhood Hits	3
SwissProt Accessions	Q9D5U0	Gene names	Aytl1b
Domain Architecture	No domain graphic available
Description	Acyltransferase-like 1-B (EC 2.3.1.-).

AYTL1_HUMAN
NC score	0.010427 (rank : 22)	θ value	8.99809 (rank : 16)
Query Neighborhood Hits	16	Target Neighborhood Hits	140	Shared Neighborhood Hits	3
SwissProt Accessions	Q7L5N7, Q6MZJ6, Q9NX23	Gene names	AYTL1
Domain Architecture	No domain graphic available
Description	Acyltransferase-like 1 (EC 2.3.1.-).

MDR1_HUMAN
NC score	0.005007 (rank : 23)	θ value	6.88961 (rank : 14)
Query Neighborhood Hits	16	Target Neighborhood Hits	112	Shared Neighborhood Hits	2
SwissProt Accessions	P08183, Q12755, Q14812	Gene names	ABCB1, MDR1, PGY1
Domain Architecture
Description	Multidrug resistance protein 1 (EC 3.6.3.44) (ATP-binding cassette sub-family B member 1) (P-glycoprotein 1) (CD243 antigen).

EGR3_HUMAN
NC score	0.004116 (rank : 24)	θ value	3.0926 (rank : 12)
Query Neighborhood Hits	16	Target Neighborhood Hits	746	Shared Neighborhood Hits	3
SwissProt Accessions	Q06889	Gene names	EGR3, PILOT
Domain Architecture	No domain graphic available
Description	Early growth response protein 3 (EGR-3) (Zinc finger protein pilot).

EGR3_MOUSE
NC score	0.003535 (rank : 25)	θ value	5.27518 (rank : 13)
Query Neighborhood Hits	16	Target Neighborhood Hits	747	Shared Neighborhood Hits	3
SwissProt Accessions	P43300, Q9R276	Gene names	Egr3, Egr-3
Domain Architecture
Description	Early growth response protein 3 (EGR-3).