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Network neighborhood for query Sequence : ITIH2_HUMAN

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ITIH2_HUMAN
SwissProt Accessions	P19823, Q14659, Q15484	Gene names	ITIH2, IGHEP2
Domain Architecture
Description	Inter-alpha-trypsin inhibitor heavy chain H2 precursor (ITI heavy chain H2) (Inter-alpha-inhibitor heavy chain 2) (Inter-alpha-trypsin inhibitor complex component II) (Serum-derived hyaluronan-associated protein) (SHAP).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

ITIH2_HUMAN
θ value	0 (rank : 1)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	29	Target Neighborhood Hits	29	Shared Neighborhood Hits	29
SwissProt Accessions	P19823, Q14659, Q15484	Gene names	ITIH2, IGHEP2
Domain Architecture
Description	Inter-alpha-trypsin inhibitor heavy chain H2 precursor (ITI heavy chain H2) (Inter-alpha-inhibitor heavy chain 2) (Inter-alpha-trypsin inhibitor complex component II) (Serum-derived hyaluronan-associated protein) (SHAP).

ITIH2_MOUSE
θ value	0 (rank : 2)	NC score	0.995163 (rank : 2)
Query Neighborhood Hits	29	Target Neighborhood Hits	27	Shared Neighborhood Hits	13
SwissProt Accessions	Q61703	Gene names	Itih2
Domain Architecture
Description	Inter-alpha-trypsin inhibitor heavy chain H2 precursor (ITI heavy chain H2) (Inter-alpha-inhibitor heavy chain 2).

ITIH3_HUMAN
θ value	0 (rank : 3)	NC score	0.971754 (rank : 4)
Query Neighborhood Hits	29	Target Neighborhood Hits	38	Shared Neighborhood Hits	10
SwissProt Accessions	Q06033, Q99085	Gene names	ITIH3
Domain Architecture
Description	Inter-alpha-trypsin inhibitor heavy chain H3 precursor (ITI heavy chain H3) (Inter-alpha-inhibitor heavy chain 3) (Serum-derived hyaluronan-associated protein) (SHAP).

ITIH3_MOUSE
θ value	0 (rank : 4)	NC score	0.972040 (rank : 3)
Query Neighborhood Hits	29	Target Neighborhood Hits	34	Shared Neighborhood Hits	10
SwissProt Accessions	Q61704	Gene names	Itih3
Domain Architecture
Description	Inter-alpha-trypsin inhibitor heavy chain H3 precursor (ITI heavy chain H3) (Inter-alpha-inhibitor heavy chain 3).

ITIH1_MOUSE
θ value	1.04281e-181 (rank : 5)	NC score	0.969348 (rank : 5)
Query Neighborhood Hits	29	Target Neighborhood Hits	31	Shared Neighborhood Hits	11
SwissProt Accessions	Q61702	Gene names	Itih1
Domain Architecture
Description	Inter-alpha-trypsin inhibitor heavy chain H1 precursor (ITI heavy chain H1) (Inter-alpha-inhibitor heavy chain 1).

ITIH1_HUMAN
θ value	2.48782e-175 (rank : 6)	NC score	0.965036 (rank : 6)
Query Neighborhood Hits	29	Target Neighborhood Hits	30	Shared Neighborhood Hits	10
SwissProt Accessions	P19827, P78455, Q01746	Gene names	ITIH1, IGHEP1
Domain Architecture
Description	Inter-alpha-trypsin inhibitor heavy chain H1 precursor (ITI heavy chain H1) (Inter-alpha-inhibitor heavy chain 1) (Inter-alpha-trypsin inhibitor complex component III) (Serum-derived hyaluronan-associated protein) (SHAP).

ITIH4_HUMAN
θ value	2.97304e-136 (rank : 7)	NC score	0.952003 (rank : 7)
Query Neighborhood Hits	29	Target Neighborhood Hits	46	Shared Neighborhood Hits	10
SwissProt Accessions	Q14624, Q15135, Q9P190, Q9UQ54	Gene names	ITIH4, IHRP, ITIHL1, PK120
Domain Architecture
Description	Inter-alpha-trypsin inhibitor heavy chain H4 precursor (ITI heavy chain H4) (Inter-alpha-inhibitor heavy chain 4) (Inter-alpha-trypsin inhibitor family heavy chain-related protein) (IHRP) (Plasma kallikrein sensitive glycoprotein 120) (PK-120) (GP120) [Contains: 70 kDa inter-alpha-trypsin inhibitor heavy chain H4; 35 kDa inter-alpha- trypsin inhibitor heavy chain H4].

CAC2D_HUMAN
θ value	0.000158464 (rank : 8)	NC score	0.304280 (rank : 9)
Query Neighborhood Hits	29	Target Neighborhood Hits	32	Shared Neighborhood Hits	11
SwissProt Accessions	P54289	Gene names	CACNA2D1, CACNL2A, CCHL2A
Domain Architecture
Description	Dihydropyridine-sensitive L-type calcium channel subunits alpha- 2/delta precursor [Contains: L-type calcium channel subunit alpha-2; L-type calcium channel subunit delta].

CAC2D_MOUSE
θ value	0.000158464 (rank : 9)	NC score	0.305760 (rank : 8)
Query Neighborhood Hits	29	Target Neighborhood Hits	42	Shared Neighborhood Hits	11
SwissProt Accessions	O08532, O08533, O08534, O08535, O08536	Gene names	Cacna2d1, Cacna2
Domain Architecture
Description	Dihydropyridine-sensitive L-type calcium channel subunits alpha- 2/delta precursor [Contains: L-type calcium channel subunit alpha-2; L-type calcium channel subunit delta].

PARP4_HUMAN
θ value	0.0431538 (rank : 10)	NC score	0.227211 (rank : 10)
Query Neighborhood Hits	29	Target Neighborhood Hits	93	Shared Neighborhood Hits	13
SwissProt Accessions	Q9UKK3, O75903, Q14682, Q9H1M6	Gene names	PARP4, ADPRTL1, KIAA0177, PARPL
Domain Architecture
Description	Poly [ADP-ribose] polymerase 4 (EC 2.4.2.30) (PARP-4) (Vault poly(ADP- ribose) polymerase) (VPARP) (193 kDa vault protein) (PARP- related/IalphaI-related H5/proline-rich) (PH5P).

PTEN_HUMAN
θ value	1.06291 (rank : 11)	NC score	0.027486 (rank : 14)
Query Neighborhood Hits	29	Target Neighborhood Hits	72	Shared Neighborhood Hits	3
SwissProt Accessions	P60484, O00633, O02679, Q6ICT7	Gene names	PTEN, MMAC1, TEP1
Domain Architecture
Description	Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual- specificity protein phosphatase PTEN (EC 3.1.3.67) (EC 3.1.3.16) (EC 3.1.3.48) (Phosphatase and tensin homolog) (Mutated in multiple advanced cancers 1).

PTEN_MOUSE
θ value	1.06291 (rank : 12)	NC score	0.027484 (rank : 15)
Query Neighborhood Hits	29	Target Neighborhood Hits	73	Shared Neighborhood Hits	3
SwissProt Accessions	O08586, Q542G1	Gene names	Pten, Mmac1
Domain Architecture
Description	Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase PTEN (EC 3.1.3.67) (Mutated in multiple advanced cancers 1).

FA29A_HUMAN
θ value	1.81305 (rank : 13)	NC score	0.027993 (rank : 13)
Query Neighborhood Hits	29	Target Neighborhood Hits	88	Shared Neighborhood Hits	3
SwissProt Accessions	Q7Z4H7, Q6IQ10, Q6NZX5, Q8IZQ4, Q96FN0, Q9H950, Q9H998, Q9HCJ8, Q9NXT8	Gene names	FAM29A, KIAA1574
Domain Architecture	No domain graphic available
Description	Protein FAM29A.

FNBP2_HUMAN
θ value	1.81305 (rank : 14)	NC score	0.012317 (rank : 19)
Query Neighborhood Hits	29	Target Neighborhood Hits	432	Shared Neighborhood Hits	6
SwissProt Accessions	O75044	Gene names	SRGAP2, FNBP2, KIAA0456
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 2 (srGAP2) (Formin-binding protein 2).

KIF3C_HUMAN
θ value	3.0926 (rank : 15)	NC score	0.008963 (rank : 22)
Query Neighborhood Hits	29	Target Neighborhood Hits	478	Shared Neighborhood Hits	7
SwissProt Accessions	O14782, O43544	Gene names	KIF3C
Domain Architecture
Description	Kinesin-like protein KIF3C.

KIF3C_MOUSE
θ value	3.0926 (rank : 16)	NC score	0.008929 (rank : 23)
Query Neighborhood Hits	29	Target Neighborhood Hits	468	Shared Neighborhood Hits	7
SwissProt Accessions	O35066, O35229	Gene names	Kif3c
Domain Architecture
Description	Kinesin-like protein KIF3C.

MYH8_HUMAN
θ value	3.0926 (rank : 17)	NC score	0.004205 (rank : 28)
Query Neighborhood Hits	29	Target Neighborhood Hits	1610	Shared Neighborhood Hits	10
SwissProt Accessions	P13535, Q14910	Gene names	MYH8
Domain Architecture
Description	Myosin-8 (Myosin heavy chain, skeletal muscle, perinatal) (MyHC- perinatal).

COKA1_HUMAN
θ value	4.03905 (rank : 18)	NC score	0.015065 (rank : 16)
Query Neighborhood Hits	29	Target Neighborhood Hits	403	Shared Neighborhood Hits	7
SwissProt Accessions	Q9P218, Q4VXQ4, Q8WUT2, Q96CY9, Q9BQU6, Q9BQU7	Gene names	COL20A1, KIAA1510
Domain Architecture
Description	Collagen alpha-1(XX) chain precursor.

MYH8_MOUSE
θ value	4.03905 (rank : 19)	NC score	0.003954 (rank : 29)
Query Neighborhood Hits	29	Target Neighborhood Hits	1600	Shared Neighborhood Hits	9
SwissProt Accessions	P13542, Q5SX36	Gene names	Myh8, Myhsp
Domain Architecture	No domain graphic available
Description	Myosin-8 (Myosin heavy chain, skeletal muscle, perinatal) (MyHC- perinatal).

MTMR5_HUMAN
θ value	5.27518 (rank : 20)	NC score	0.007505 (rank : 26)
Query Neighborhood Hits	29	Target Neighborhood Hits	141	Shared Neighborhood Hits	2
SwissProt Accessions	O95248, O60228, Q5JXD8, Q5PPM2, Q96GR9, Q9UGB8	Gene names	SBF1, MTMR5
Domain Architecture
Description	SET-binding factor 1 (Sbf1) (Myotubularin-related protein 5).

NFRKB_MOUSE
θ value	5.27518 (rank : 21)	NC score	0.009397 (rank : 20)
Query Neighborhood Hits	29	Target Neighborhood Hits	393	Shared Neighborhood Hits	3
SwissProt Accessions	Q6PIJ4, Q8BWV5, Q8K0X6	Gene names	Nfrkb
Domain Architecture	No domain graphic available
Description	Nuclear factor related to kappa-B-binding protein (DNA-binding protein R kappa-B).

SETD2_HUMAN
θ value	5.27518 (rank : 22)	NC score	0.008565 (rank : 25)
Query Neighborhood Hits	29	Target Neighborhood Hits	412	Shared Neighborhood Hits	2
SwissProt Accessions	Q9BYW2, O75397, O75405, Q17RW8, Q5BKS9, Q5QGN2, Q69YI5, Q6IN64, Q6ZN53, Q6ZS25, Q8N3R0, Q8TCN0, Q9C0D1, Q9H696, Q9NZW9	Gene names	SETD2, HIF1, HYPB, KIAA1732, SET2
Domain Architecture	No domain graphic available
Description	Histone-lysine N-methyltransferase, H3 lysine-36-specific (EC 2.1.1.43) (SET domain-containing protein 2) (hSET2) (Huntingtin- interacting protein HYPB) (Huntingtin-interacting protein 1) (HIF-1) (p231HBP).

UGPA2_HUMAN
θ value	5.27518 (rank : 23)	NC score	0.014657 (rank : 17)
Query Neighborhood Hits	29	Target Neighborhood Hits	14	Shared Neighborhood Hits	3
SwissProt Accessions	Q16851, Q86Y81, Q9BU15	Gene names	UGP2
Domain Architecture
Description	UTP--glucose-1-phosphate uridylyltransferase 2 (EC 2.7.7.9) (UDP- glucose pyrophosphorylase 2) (UDPGP 2) (UGPase 2).

GSCR1_HUMAN
θ value	6.88961 (rank : 24)	NC score	0.007039 (rank : 27)
Query Neighborhood Hits	29	Target Neighborhood Hits	674	Shared Neighborhood Hits	4
SwissProt Accessions	Q9NZM4	Gene names	GLTSCR1
Domain Architecture	No domain graphic available
Description	Glioma tumor suppressor candidate region gene 1 protein.

MYH4_HUMAN
θ value	6.88961 (rank : 25)	NC score	0.003883 (rank : 30)
Query Neighborhood Hits	29	Target Neighborhood Hits	1377	Shared Neighborhood Hits	9
SwissProt Accessions	Q9Y623	Gene names	MYH4
Domain Architecture
Description	Myosin-4 (Myosin heavy chain, skeletal muscle, fetal) (Myosin heavy chain IIb) (MyHC-IIb).

SRGP1_HUMAN
θ value	6.88961 (rank : 26)	NC score	0.009114 (rank : 21)
Query Neighborhood Hits	29	Target Neighborhood Hits	390	Shared Neighborhood Hits	6
SwissProt Accessions	Q7Z6B7, Q9H8A3, Q9P2P2	Gene names	SRGAP1, ARHGAP13, KIAA1304
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 1 (srGAP1) (Rho-GTPase- activating protein 13).

FANCA_HUMAN
θ value	8.99809 (rank : 27)	NC score	0.008637 (rank : 24)
Query Neighborhood Hits	29	Target Neighborhood Hits	18	Shared Neighborhood Hits	2
SwissProt Accessions	O15360, O75266, Q6PL10, Q92497, Q96H18, Q9UEA5, Q9UEL8, Q9UEL9, Q9UPK3, Q9Y6M2	Gene names	FANCA, FAA
Domain Architecture
Description	Fanconi anemia group A protein (Protein FACA).

PLK4_MOUSE
θ value	8.99809 (rank : 28)	NC score	-0.001683 (rank : 31)
Query Neighborhood Hits	29	Target Neighborhood Hits	879	Shared Neighborhood Hits	2
SwissProt Accessions	Q64702, Q6PEP6, Q78EG6, Q8R0I5, Q9CVR6, Q9CVU6	Gene names	Plk4, Sak, Stk18
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase PLK4 (EC 2.7.11.21) (Polo-like kinase 4) (PLK-4) (Serine/threonine-protein kinase Sak) (Serine/threonine- protein kinase 18).

UGPA2_MOUSE
θ value	8.99809 (rank : 29)	NC score	0.012714 (rank : 18)
Query Neighborhood Hits	29	Target Neighborhood Hits	11	Shared Neighborhood Hits	3
SwissProt Accessions	Q91ZJ5, Q8R3D2	Gene names	Ugp2
Domain Architecture	No domain graphic available
Description	UTP--glucose-1-phosphate uridylyltransferase 2 (EC 2.7.7.9) (UDP- glucose pyrophosphorylase 2) (UDPGP 2) (UGPase 2).

LHR2A_HUMAN
θ value	θ > 10 (rank : 30)	NC score	0.205624 (rank : 11)
Query Neighborhood Hits	29	Target Neighborhood Hits	16	Shared Neighborhood Hits	6
SwissProt Accessions	O00534, Q6UN19, Q6UN20, Q9BVF8	Gene names	LOH11CR2A, BCSC1
Domain Architecture
Description	Loss of heterozygosity 11 chromosomal region 2 gene A protein (Breast cancer suppressor candidate 1) (BCSC-1).

LHR2A_MOUSE
θ value	θ > 10 (rank : 31)	NC score	0.189843 (rank : 12)
Query Neighborhood Hits	29	Target Neighborhood Hits	16	Shared Neighborhood Hits	7
SwissProt Accessions	Q99KC8, Q3TTU2, Q6UN22, Q8BHA8, Q9CTV9	Gene names	Loh11cr2a
Domain Architecture
Description	Loss of heterozygosity 11 chromosomal region 2 gene A protein homolog.

Hits sorted by NC score

ITIH2_HUMAN
NC score	0.999962 (rank : 1)	θ value	0 (rank : 1)
Query Neighborhood Hits	29	Target Neighborhood Hits	29	Shared Neighborhood Hits	29
SwissProt Accessions	P19823, Q14659, Q15484	Gene names	ITIH2, IGHEP2
Domain Architecture
Description	Inter-alpha-trypsin inhibitor heavy chain H2 precursor (ITI heavy chain H2) (Inter-alpha-inhibitor heavy chain 2) (Inter-alpha-trypsin inhibitor complex component II) (Serum-derived hyaluronan-associated protein) (SHAP).

ITIH2_MOUSE
NC score	0.995163 (rank : 2)	θ value	0 (rank : 2)
Query Neighborhood Hits	29	Target Neighborhood Hits	27	Shared Neighborhood Hits	13
SwissProt Accessions	Q61703	Gene names	Itih2
Domain Architecture
Description	Inter-alpha-trypsin inhibitor heavy chain H2 precursor (ITI heavy chain H2) (Inter-alpha-inhibitor heavy chain 2).

ITIH3_MOUSE
NC score	0.972040 (rank : 3)	θ value	0 (rank : 4)
Query Neighborhood Hits	29	Target Neighborhood Hits	34	Shared Neighborhood Hits	10
SwissProt Accessions	Q61704	Gene names	Itih3
Domain Architecture
Description	Inter-alpha-trypsin inhibitor heavy chain H3 precursor (ITI heavy chain H3) (Inter-alpha-inhibitor heavy chain 3).

ITIH3_HUMAN
NC score	0.971754 (rank : 4)	θ value	0 (rank : 3)
Query Neighborhood Hits	29	Target Neighborhood Hits	38	Shared Neighborhood Hits	10
SwissProt Accessions	Q06033, Q99085	Gene names	ITIH3
Domain Architecture
Description	Inter-alpha-trypsin inhibitor heavy chain H3 precursor (ITI heavy chain H3) (Inter-alpha-inhibitor heavy chain 3) (Serum-derived hyaluronan-associated protein) (SHAP).

ITIH1_MOUSE
NC score	0.969348 (rank : 5)	θ value	1.04281e-181 (rank : 5)
Query Neighborhood Hits	29	Target Neighborhood Hits	31	Shared Neighborhood Hits	11
SwissProt Accessions	Q61702	Gene names	Itih1
Domain Architecture
Description	Inter-alpha-trypsin inhibitor heavy chain H1 precursor (ITI heavy chain H1) (Inter-alpha-inhibitor heavy chain 1).

ITIH1_HUMAN
NC score	0.965036 (rank : 6)	θ value	2.48782e-175 (rank : 6)
Query Neighborhood Hits	29	Target Neighborhood Hits	30	Shared Neighborhood Hits	10
SwissProt Accessions	P19827, P78455, Q01746	Gene names	ITIH1, IGHEP1
Domain Architecture
Description	Inter-alpha-trypsin inhibitor heavy chain H1 precursor (ITI heavy chain H1) (Inter-alpha-inhibitor heavy chain 1) (Inter-alpha-trypsin inhibitor complex component III) (Serum-derived hyaluronan-associated protein) (SHAP).

ITIH4_HUMAN
NC score	0.952003 (rank : 7)	θ value	2.97304e-136 (rank : 7)
Query Neighborhood Hits	29	Target Neighborhood Hits	46	Shared Neighborhood Hits	10
SwissProt Accessions	Q14624, Q15135, Q9P190, Q9UQ54	Gene names	ITIH4, IHRP, ITIHL1, PK120
Domain Architecture
Description	Inter-alpha-trypsin inhibitor heavy chain H4 precursor (ITI heavy chain H4) (Inter-alpha-inhibitor heavy chain 4) (Inter-alpha-trypsin inhibitor family heavy chain-related protein) (IHRP) (Plasma kallikrein sensitive glycoprotein 120) (PK-120) (GP120) [Contains: 70 kDa inter-alpha-trypsin inhibitor heavy chain H4; 35 kDa inter-alpha- trypsin inhibitor heavy chain H4].

CAC2D_MOUSE
NC score	0.305760 (rank : 8)	θ value	0.000158464 (rank : 9)
Query Neighborhood Hits	29	Target Neighborhood Hits	42	Shared Neighborhood Hits	11
SwissProt Accessions	O08532, O08533, O08534, O08535, O08536	Gene names	Cacna2d1, Cacna2
Domain Architecture
Description	Dihydropyridine-sensitive L-type calcium channel subunits alpha- 2/delta precursor [Contains: L-type calcium channel subunit alpha-2; L-type calcium channel subunit delta].

CAC2D_HUMAN
NC score	0.304280 (rank : 9)	θ value	0.000158464 (rank : 8)
Query Neighborhood Hits	29	Target Neighborhood Hits	32	Shared Neighborhood Hits	11
SwissProt Accessions	P54289	Gene names	CACNA2D1, CACNL2A, CCHL2A
Domain Architecture
Description	Dihydropyridine-sensitive L-type calcium channel subunits alpha- 2/delta precursor [Contains: L-type calcium channel subunit alpha-2; L-type calcium channel subunit delta].

PARP4_HUMAN
NC score	0.227211 (rank : 10)	θ value	0.0431538 (rank : 10)
Query Neighborhood Hits	29	Target Neighborhood Hits	93	Shared Neighborhood Hits	13
SwissProt Accessions	Q9UKK3, O75903, Q14682, Q9H1M6	Gene names	PARP4, ADPRTL1, KIAA0177, PARPL
Domain Architecture
Description	Poly [ADP-ribose] polymerase 4 (EC 2.4.2.30) (PARP-4) (Vault poly(ADP- ribose) polymerase) (VPARP) (193 kDa vault protein) (PARP- related/IalphaI-related H5/proline-rich) (PH5P).

LHR2A_HUMAN
NC score	0.205624 (rank : 11)	θ value	θ > 10 (rank : 30)
Query Neighborhood Hits	29	Target Neighborhood Hits	16	Shared Neighborhood Hits	6
SwissProt Accessions	O00534, Q6UN19, Q6UN20, Q9BVF8	Gene names	LOH11CR2A, BCSC1
Domain Architecture
Description	Loss of heterozygosity 11 chromosomal region 2 gene A protein (Breast cancer suppressor candidate 1) (BCSC-1).

LHR2A_MOUSE
NC score	0.189843 (rank : 12)	θ value	θ > 10 (rank : 31)
Query Neighborhood Hits	29	Target Neighborhood Hits	16	Shared Neighborhood Hits	7
SwissProt Accessions	Q99KC8, Q3TTU2, Q6UN22, Q8BHA8, Q9CTV9	Gene names	Loh11cr2a
Domain Architecture
Description	Loss of heterozygosity 11 chromosomal region 2 gene A protein homolog.

FA29A_HUMAN
NC score	0.027993 (rank : 13)	θ value	1.81305 (rank : 13)
Query Neighborhood Hits	29	Target Neighborhood Hits	88	Shared Neighborhood Hits	3
SwissProt Accessions	Q7Z4H7, Q6IQ10, Q6NZX5, Q8IZQ4, Q96FN0, Q9H950, Q9H998, Q9HCJ8, Q9NXT8	Gene names	FAM29A, KIAA1574
Domain Architecture	No domain graphic available
Description	Protein FAM29A.

PTEN_HUMAN
NC score	0.027486 (rank : 14)	θ value	1.06291 (rank : 11)
Query Neighborhood Hits	29	Target Neighborhood Hits	72	Shared Neighborhood Hits	3
SwissProt Accessions	P60484, O00633, O02679, Q6ICT7	Gene names	PTEN, MMAC1, TEP1
Domain Architecture
Description	Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual- specificity protein phosphatase PTEN (EC 3.1.3.67) (EC 3.1.3.16) (EC 3.1.3.48) (Phosphatase and tensin homolog) (Mutated in multiple advanced cancers 1).

PTEN_MOUSE
NC score	0.027484 (rank : 15)	θ value	1.06291 (rank : 12)
Query Neighborhood Hits	29	Target Neighborhood Hits	73	Shared Neighborhood Hits	3
SwissProt Accessions	O08586, Q542G1	Gene names	Pten, Mmac1
Domain Architecture
Description	Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase PTEN (EC 3.1.3.67) (Mutated in multiple advanced cancers 1).

COKA1_HUMAN
NC score	0.015065 (rank : 16)	θ value	4.03905 (rank : 18)
Query Neighborhood Hits	29	Target Neighborhood Hits	403	Shared Neighborhood Hits	7
SwissProt Accessions	Q9P218, Q4VXQ4, Q8WUT2, Q96CY9, Q9BQU6, Q9BQU7	Gene names	COL20A1, KIAA1510
Domain Architecture
Description	Collagen alpha-1(XX) chain precursor.

UGPA2_HUMAN
NC score	0.014657 (rank : 17)	θ value	5.27518 (rank : 23)
Query Neighborhood Hits	29	Target Neighborhood Hits	14	Shared Neighborhood Hits	3
SwissProt Accessions	Q16851, Q86Y81, Q9BU15	Gene names	UGP2
Domain Architecture
Description	UTP--glucose-1-phosphate uridylyltransferase 2 (EC 2.7.7.9) (UDP- glucose pyrophosphorylase 2) (UDPGP 2) (UGPase 2).

UGPA2_MOUSE
NC score	0.012714 (rank : 18)	θ value	8.99809 (rank : 29)
Query Neighborhood Hits	29	Target Neighborhood Hits	11	Shared Neighborhood Hits	3
SwissProt Accessions	Q91ZJ5, Q8R3D2	Gene names	Ugp2
Domain Architecture	No domain graphic available
Description	UTP--glucose-1-phosphate uridylyltransferase 2 (EC 2.7.7.9) (UDP- glucose pyrophosphorylase 2) (UDPGP 2) (UGPase 2).

FNBP2_HUMAN
NC score	0.012317 (rank : 19)	θ value	1.81305 (rank : 14)
Query Neighborhood Hits	29	Target Neighborhood Hits	432	Shared Neighborhood Hits	6
SwissProt Accessions	O75044	Gene names	SRGAP2, FNBP2, KIAA0456
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 2 (srGAP2) (Formin-binding protein 2).

NFRKB_MOUSE
NC score	0.009397 (rank : 20)	θ value	5.27518 (rank : 21)
Query Neighborhood Hits	29	Target Neighborhood Hits	393	Shared Neighborhood Hits	3
SwissProt Accessions	Q6PIJ4, Q8BWV5, Q8K0X6	Gene names	Nfrkb
Domain Architecture	No domain graphic available
Description	Nuclear factor related to kappa-B-binding protein (DNA-binding protein R kappa-B).

SRGP1_HUMAN
NC score	0.009114 (rank : 21)	θ value	6.88961 (rank : 26)
Query Neighborhood Hits	29	Target Neighborhood Hits	390	Shared Neighborhood Hits	6
SwissProt Accessions	Q7Z6B7, Q9H8A3, Q9P2P2	Gene names	SRGAP1, ARHGAP13, KIAA1304
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 1 (srGAP1) (Rho-GTPase- activating protein 13).

KIF3C_HUMAN
NC score	0.008963 (rank : 22)	θ value	3.0926 (rank : 15)
Query Neighborhood Hits	29	Target Neighborhood Hits	478	Shared Neighborhood Hits	7
SwissProt Accessions	O14782, O43544	Gene names	KIF3C
Domain Architecture
Description	Kinesin-like protein KIF3C.

KIF3C_MOUSE
NC score	0.008929 (rank : 23)	θ value	3.0926 (rank : 16)
Query Neighborhood Hits	29	Target Neighborhood Hits	468	Shared Neighborhood Hits	7
SwissProt Accessions	O35066, O35229	Gene names	Kif3c
Domain Architecture
Description	Kinesin-like protein KIF3C.

FANCA_HUMAN
NC score	0.008637 (rank : 24)	θ value	8.99809 (rank : 27)
Query Neighborhood Hits	29	Target Neighborhood Hits	18	Shared Neighborhood Hits	2
SwissProt Accessions	O15360, O75266, Q6PL10, Q92497, Q96H18, Q9UEA5, Q9UEL8, Q9UEL9, Q9UPK3, Q9Y6M2	Gene names	FANCA, FAA
Domain Architecture
Description	Fanconi anemia group A protein (Protein FACA).

SETD2_HUMAN
NC score	0.008565 (rank : 25)	θ value	5.27518 (rank : 22)
Query Neighborhood Hits	29	Target Neighborhood Hits	412	Shared Neighborhood Hits	2
SwissProt Accessions	Q9BYW2, O75397, O75405, Q17RW8, Q5BKS9, Q5QGN2, Q69YI5, Q6IN64, Q6ZN53, Q6ZS25, Q8N3R0, Q8TCN0, Q9C0D1, Q9H696, Q9NZW9	Gene names	SETD2, HIF1, HYPB, KIAA1732, SET2
Domain Architecture	No domain graphic available
Description	Histone-lysine N-methyltransferase, H3 lysine-36-specific (EC 2.1.1.43) (SET domain-containing protein 2) (hSET2) (Huntingtin- interacting protein HYPB) (Huntingtin-interacting protein 1) (HIF-1) (p231HBP).

MTMR5_HUMAN
NC score	0.007505 (rank : 26)	θ value	5.27518 (rank : 20)
Query Neighborhood Hits	29	Target Neighborhood Hits	141	Shared Neighborhood Hits	2
SwissProt Accessions	O95248, O60228, Q5JXD8, Q5PPM2, Q96GR9, Q9UGB8	Gene names	SBF1, MTMR5
Domain Architecture
Description	SET-binding factor 1 (Sbf1) (Myotubularin-related protein 5).

GSCR1_HUMAN
NC score	0.007039 (rank : 27)	θ value	6.88961 (rank : 24)
Query Neighborhood Hits	29	Target Neighborhood Hits	674	Shared Neighborhood Hits	4
SwissProt Accessions	Q9NZM4	Gene names	GLTSCR1
Domain Architecture	No domain graphic available
Description	Glioma tumor suppressor candidate region gene 1 protein.

MYH8_HUMAN
NC score	0.004205 (rank : 28)	θ value	3.0926 (rank : 17)
Query Neighborhood Hits	29	Target Neighborhood Hits	1610	Shared Neighborhood Hits	10
SwissProt Accessions	P13535, Q14910	Gene names	MYH8
Domain Architecture
Description	Myosin-8 (Myosin heavy chain, skeletal muscle, perinatal) (MyHC- perinatal).

MYH8_MOUSE
NC score	0.003954 (rank : 29)	θ value	4.03905 (rank : 19)
Query Neighborhood Hits	29	Target Neighborhood Hits	1600	Shared Neighborhood Hits	9
SwissProt Accessions	P13542, Q5SX36	Gene names	Myh8, Myhsp
Domain Architecture	No domain graphic available
Description	Myosin-8 (Myosin heavy chain, skeletal muscle, perinatal) (MyHC- perinatal).

MYH4_HUMAN
NC score	0.003883 (rank : 30)	θ value	6.88961 (rank : 25)
Query Neighborhood Hits	29	Target Neighborhood Hits	1377	Shared Neighborhood Hits	9
SwissProt Accessions	Q9Y623	Gene names	MYH4
Domain Architecture
Description	Myosin-4 (Myosin heavy chain, skeletal muscle, fetal) (Myosin heavy chain IIb) (MyHC-IIb).

PLK4_MOUSE
NC score	-0.001683 (rank : 31)	θ value	8.99809 (rank : 28)
Query Neighborhood Hits	29	Target Neighborhood Hits	879	Shared Neighborhood Hits	2
SwissProt Accessions	Q64702, Q6PEP6, Q78EG6, Q8R0I5, Q9CVR6, Q9CVU6	Gene names	Plk4, Sak, Stk18
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase PLK4 (EC 2.7.11.21) (Polo-like kinase 4) (PLK-4) (Serine/threonine-protein kinase Sak) (Serine/threonine- protein kinase 18).