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Network neighborhood for query Sequence : CXX1_HUMAN

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CXX1_HUMAN
SwissProt Accessions	O15255	Gene names	CXX1
Domain Architecture	No domain graphic available
Description	CAAX box protein 1 (Cerebral protein 5).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

CXX1_HUMAN
θ value	9.76566e-63 (rank : 1)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	17	Target Neighborhood Hits	17	Shared Neighborhood Hits	17
SwissProt Accessions	O15255	Gene names	CXX1
Domain Architecture	No domain graphic available
Description	CAAX box protein 1 (Cerebral protein 5).

CD248_HUMAN
θ value	0.0961366 (rank : 2)	NC score	0.058827 (rank : 3)
Query Neighborhood Hits	17	Target Neighborhood Hits	679	Shared Neighborhood Hits	8
SwissProt Accessions	Q9HCU0, Q3SX55, Q96KB6	Gene names	CD248, CD164L1, TEM1
Domain Architecture	No domain graphic available
Description	Endosialin precursor (Tumor endothelial marker 1) (CD248 antigen).

POLS2_HUMAN
θ value	0.163984 (rank : 3)	NC score	0.030035 (rank : 13)
Query Neighborhood Hits	17	Target Neighborhood Hits	192	Shared Neighborhood Hits	2
SwissProt Accessions	Q5K4E3, Q8NBY4	Gene names	PRSS36
Domain Architecture	No domain graphic available
Description	Polyserase-2 precursor (EC 3.4.21.-) (Polyserine protease 2) (Protease serine 36).

SPHK2_MOUSE
θ value	0.47712 (rank : 4)	NC score	0.084537 (rank : 2)
Query Neighborhood Hits	17	Target Neighborhood Hits	78	Shared Neighborhood Hits	4
SwissProt Accessions	Q9JIA7, Q91VA9, Q9DBH6	Gene names	Sphk2
Domain Architecture
Description	Sphingosine kinase 2 (EC 2.7.1.-) (SK 2) (SPK 2).

SMO_MOUSE
θ value	0.62314 (rank : 5)	NC score	0.049481 (rank : 9)
Query Neighborhood Hits	17	Target Neighborhood Hits	61	Shared Neighborhood Hits	2
SwissProt Accessions	P56726	Gene names	Smo, Smoh
Domain Architecture	No domain graphic available
Description	Smoothened homolog precursor (SMO).

DAB2_HUMAN
θ value	1.38821 (rank : 6)	NC score	0.058655 (rank : 4)
Query Neighborhood Hits	17	Target Neighborhood Hits	197	Shared Neighborhood Hits	2
SwissProt Accessions	P98082, Q13598, Q9BTY0, Q9UK04	Gene names	DAB2, DOC2
Domain Architecture
Description	Disabled homolog 2 (Differentially expressed protein 2) (DOC-2).

BCL9_HUMAN
θ value	1.81305 (rank : 7)	NC score	0.057446 (rank : 5)
Query Neighborhood Hits	17	Target Neighborhood Hits	1008	Shared Neighborhood Hits	7
SwissProt Accessions	O00512	Gene names	BCL9
Domain Architecture	No domain graphic available
Description	B-cell lymphoma 9 protein (Bcl-9) (Legless homolog).

PLXD1_HUMAN
θ value	1.81305 (rank : 8)	NC score	0.029755 (rank : 14)
Query Neighborhood Hits	17	Target Neighborhood Hits	89	Shared Neighborhood Hits	2
SwissProt Accessions	Q9Y4D7, Q6PJS9, Q8IZJ2, Q9BTQ2	Gene names	PLXND1, KIAA0620
Domain Architecture	No domain graphic available
Description	Plexin-D1 precursor.

TRI66_MOUSE
θ value	1.81305 (rank : 9)	NC score	0.038562 (rank : 12)
Query Neighborhood Hits	17	Target Neighborhood Hits	491	Shared Neighborhood Hits	4
SwissProt Accessions	Q924W6	Gene names	Trim66
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 66.

STON2_HUMAN
θ value	2.36792 (rank : 10)	NC score	0.044859 (rank : 11)
Query Neighborhood Hits	17	Target Neighborhood Hits	115	Shared Neighborhood Hits	2
SwissProt Accessions	Q8WXE9, Q6NT47, Q96RI7, Q96RU6	Gene names	STON2, STN2, STNB
Domain Architecture
Description	Stonin-2 (Stoned B).

LARG2_HUMAN
θ value	4.03905 (rank : 11)	NC score	0.051107 (rank : 7)
Query Neighborhood Hits	17	Target Neighborhood Hits	14	Shared Neighborhood Hits	3
SwissProt Accessions	Q8N3Y3, Q8N8Y6, Q8NAK3, Q8WY62	Gene names	GYLTL1B
Domain Architecture	No domain graphic available
Description	Glycosyltransferase-like protein LARGE2 (EC 2.4.-.-) (Glycosyltransferase-like 1B).

ADA15_MOUSE
θ value	5.27518 (rank : 12)	NC score	0.019193 (rank : 16)
Query Neighborhood Hits	17	Target Neighborhood Hits	324	Shared Neighborhood Hits	5
SwissProt Accessions	O88839, Q3U7C2, Q8C7Z0, Q91VS9, Q9QYL2	Gene names	Adam15, Mdc15
Domain Architecture
Description	ADAM 15 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase domain 15) (Metalloproteinase-like, disintegrin-like, and cysteine- rich protein 15) (MDC-15) (Metalloprotease RGD disintegrin protein) (Metargidin) (AD56).

LARG2_MOUSE
θ value	5.27518 (rank : 13)	NC score	0.049228 (rank : 10)
Query Neighborhood Hits	17	Target Neighborhood Hits	11	Shared Neighborhood Hits	3
SwissProt Accessions	Q5XPT3, Q5XPT2, Q8BJZ8, Q8K253	Gene names	Gyltl1b
Domain Architecture	No domain graphic available
Description	Glycosyltransferase-like protein LARGE2 (EC 2.4.-.-) (Glycosyltransferase-like 1B).

BCL9_MOUSE
θ value	6.88961 (rank : 14)	NC score	0.055655 (rank : 6)
Query Neighborhood Hits	17	Target Neighborhood Hits	770	Shared Neighborhood Hits	5
SwissProt Accessions	Q9D219, Q67FX9, Q8BUJ8, Q8VE74	Gene names	Bcl9
Domain Architecture	No domain graphic available
Description	B-cell lymphoma 9 protein (Bcl-9).

LOXL1_MOUSE
θ value	6.88961 (rank : 15)	NC score	0.022603 (rank : 15)
Query Neighborhood Hits	17	Target Neighborhood Hits	58	Shared Neighborhood Hits	3
SwissProt Accessions	P97873, Q91ZY4, Q99KX3	Gene names	Loxl1, Lox2, Loxl
Domain Architecture
Description	Lysyl oxidase homolog 1 precursor (EC 1.4.3.-) (Lysyl oxidase-like protein 1) (Lysyl oxidase 2).

ADA15_HUMAN
θ value	8.99809 (rank : 16)	NC score	0.016938 (rank : 17)
Query Neighborhood Hits	17	Target Neighborhood Hits	288	Shared Neighborhood Hits	5
SwissProt Accessions	Q13444, Q13493, Q96C78	Gene names	ADAM15, MDC15
Domain Architecture
Description	ADAM 15 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase domain 15) (Metalloproteinase-like, disintegrin-like, and cysteine- rich protein 15) (MDC-15) (Metalloprotease RGD disintegrin protein) (Metargidin).

KR105_HUMAN
θ value	8.99809 (rank : 17)	NC score	0.013976 (rank : 18)
Query Neighborhood Hits	17	Target Neighborhood Hits	271	Shared Neighborhood Hits	5
SwissProt Accessions	P60370, Q70LJ3	Gene names	KRTAP10-5, KAP10.5, KAP18-5, KRTAP10.5, KRTAP18-5, KRTAP18.5
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 10-5 (Keratin-associated protein 10.5) (High sulfur keratin-associated protein 10.5) (Keratin-associated protein 18-5) (Keratin-associated protein 18.5).

SPHK2_HUMAN
θ value	θ > 10 (rank : 18)	NC score	0.050032 (rank : 8)
Query Neighborhood Hits	17	Target Neighborhood Hits	81	Shared Neighborhood Hits	1
SwissProt Accessions	Q9NRA0, Q9BRN1, Q9H0Q2, Q9NWU7	Gene names	SPHK2
Domain Architecture
Description	Sphingosine kinase 2 (EC 2.7.1.-) (SK 2) (SPK 2).

Hits sorted by NC score

CXX1_HUMAN
NC score	0.999962 (rank : 1)	θ value	9.76566e-63 (rank : 1)
Query Neighborhood Hits	17	Target Neighborhood Hits	17	Shared Neighborhood Hits	17
SwissProt Accessions	O15255	Gene names	CXX1
Domain Architecture	No domain graphic available
Description	CAAX box protein 1 (Cerebral protein 5).

SPHK2_MOUSE
NC score	0.084537 (rank : 2)	θ value	0.47712 (rank : 4)
Query Neighborhood Hits	17	Target Neighborhood Hits	78	Shared Neighborhood Hits	4
SwissProt Accessions	Q9JIA7, Q91VA9, Q9DBH6	Gene names	Sphk2
Domain Architecture
Description	Sphingosine kinase 2 (EC 2.7.1.-) (SK 2) (SPK 2).

CD248_HUMAN
NC score	0.058827 (rank : 3)	θ value	0.0961366 (rank : 2)
Query Neighborhood Hits	17	Target Neighborhood Hits	679	Shared Neighborhood Hits	8
SwissProt Accessions	Q9HCU0, Q3SX55, Q96KB6	Gene names	CD248, CD164L1, TEM1
Domain Architecture	No domain graphic available
Description	Endosialin precursor (Tumor endothelial marker 1) (CD248 antigen).

DAB2_HUMAN
NC score	0.058655 (rank : 4)	θ value	1.38821 (rank : 6)
Query Neighborhood Hits	17	Target Neighborhood Hits	197	Shared Neighborhood Hits	2
SwissProt Accessions	P98082, Q13598, Q9BTY0, Q9UK04	Gene names	DAB2, DOC2
Domain Architecture
Description	Disabled homolog 2 (Differentially expressed protein 2) (DOC-2).

BCL9_HUMAN
NC score	0.057446 (rank : 5)	θ value	1.81305 (rank : 7)
Query Neighborhood Hits	17	Target Neighborhood Hits	1008	Shared Neighborhood Hits	7
SwissProt Accessions	O00512	Gene names	BCL9
Domain Architecture	No domain graphic available
Description	B-cell lymphoma 9 protein (Bcl-9) (Legless homolog).

BCL9_MOUSE
NC score	0.055655 (rank : 6)	θ value	6.88961 (rank : 14)
Query Neighborhood Hits	17	Target Neighborhood Hits	770	Shared Neighborhood Hits	5
SwissProt Accessions	Q9D219, Q67FX9, Q8BUJ8, Q8VE74	Gene names	Bcl9
Domain Architecture	No domain graphic available
Description	B-cell lymphoma 9 protein (Bcl-9).

LARG2_HUMAN
NC score	0.051107 (rank : 7)	θ value	4.03905 (rank : 11)
Query Neighborhood Hits	17	Target Neighborhood Hits	14	Shared Neighborhood Hits	3
SwissProt Accessions	Q8N3Y3, Q8N8Y6, Q8NAK3, Q8WY62	Gene names	GYLTL1B
Domain Architecture	No domain graphic available
Description	Glycosyltransferase-like protein LARGE2 (EC 2.4.-.-) (Glycosyltransferase-like 1B).

SPHK2_HUMAN
NC score	0.050032 (rank : 8)	θ value	θ > 10 (rank : 18)
Query Neighborhood Hits	17	Target Neighborhood Hits	81	Shared Neighborhood Hits	1
SwissProt Accessions	Q9NRA0, Q9BRN1, Q9H0Q2, Q9NWU7	Gene names	SPHK2
Domain Architecture
Description	Sphingosine kinase 2 (EC 2.7.1.-) (SK 2) (SPK 2).

SMO_MOUSE
NC score	0.049481 (rank : 9)	θ value	0.62314 (rank : 5)
Query Neighborhood Hits	17	Target Neighborhood Hits	61	Shared Neighborhood Hits	2
SwissProt Accessions	P56726	Gene names	Smo, Smoh
Domain Architecture	No domain graphic available
Description	Smoothened homolog precursor (SMO).

LARG2_MOUSE
NC score	0.049228 (rank : 10)	θ value	5.27518 (rank : 13)
Query Neighborhood Hits	17	Target Neighborhood Hits	11	Shared Neighborhood Hits	3
SwissProt Accessions	Q5XPT3, Q5XPT2, Q8BJZ8, Q8K253	Gene names	Gyltl1b
Domain Architecture	No domain graphic available
Description	Glycosyltransferase-like protein LARGE2 (EC 2.4.-.-) (Glycosyltransferase-like 1B).

STON2_HUMAN
NC score	0.044859 (rank : 11)	θ value	2.36792 (rank : 10)
Query Neighborhood Hits	17	Target Neighborhood Hits	115	Shared Neighborhood Hits	2
SwissProt Accessions	Q8WXE9, Q6NT47, Q96RI7, Q96RU6	Gene names	STON2, STN2, STNB
Domain Architecture
Description	Stonin-2 (Stoned B).

TRI66_MOUSE
NC score	0.038562 (rank : 12)	θ value	1.81305 (rank : 9)
Query Neighborhood Hits	17	Target Neighborhood Hits	491	Shared Neighborhood Hits	4
SwissProt Accessions	Q924W6	Gene names	Trim66
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 66.

POLS2_HUMAN
NC score	0.030035 (rank : 13)	θ value	0.163984 (rank : 3)
Query Neighborhood Hits	17	Target Neighborhood Hits	192	Shared Neighborhood Hits	2
SwissProt Accessions	Q5K4E3, Q8NBY4	Gene names	PRSS36
Domain Architecture	No domain graphic available
Description	Polyserase-2 precursor (EC 3.4.21.-) (Polyserine protease 2) (Protease serine 36).

PLXD1_HUMAN
NC score	0.029755 (rank : 14)	θ value	1.81305 (rank : 8)
Query Neighborhood Hits	17	Target Neighborhood Hits	89	Shared Neighborhood Hits	2
SwissProt Accessions	Q9Y4D7, Q6PJS9, Q8IZJ2, Q9BTQ2	Gene names	PLXND1, KIAA0620
Domain Architecture	No domain graphic available
Description	Plexin-D1 precursor.

LOXL1_MOUSE
NC score	0.022603 (rank : 15)	θ value	6.88961 (rank : 15)
Query Neighborhood Hits	17	Target Neighborhood Hits	58	Shared Neighborhood Hits	3
SwissProt Accessions	P97873, Q91ZY4, Q99KX3	Gene names	Loxl1, Lox2, Loxl
Domain Architecture
Description	Lysyl oxidase homolog 1 precursor (EC 1.4.3.-) (Lysyl oxidase-like protein 1) (Lysyl oxidase 2).

ADA15_MOUSE
NC score	0.019193 (rank : 16)	θ value	5.27518 (rank : 12)
Query Neighborhood Hits	17	Target Neighborhood Hits	324	Shared Neighborhood Hits	5
SwissProt Accessions	O88839, Q3U7C2, Q8C7Z0, Q91VS9, Q9QYL2	Gene names	Adam15, Mdc15
Domain Architecture
Description	ADAM 15 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase domain 15) (Metalloproteinase-like, disintegrin-like, and cysteine- rich protein 15) (MDC-15) (Metalloprotease RGD disintegrin protein) (Metargidin) (AD56).

ADA15_HUMAN
NC score	0.016938 (rank : 17)	θ value	8.99809 (rank : 16)
Query Neighborhood Hits	17	Target Neighborhood Hits	288	Shared Neighborhood Hits	5
SwissProt Accessions	Q13444, Q13493, Q96C78	Gene names	ADAM15, MDC15
Domain Architecture
Description	ADAM 15 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase domain 15) (Metalloproteinase-like, disintegrin-like, and cysteine- rich protein 15) (MDC-15) (Metalloprotease RGD disintegrin protein) (Metargidin).

KR105_HUMAN
NC score	0.013976 (rank : 18)	θ value	8.99809 (rank : 17)
Query Neighborhood Hits	17	Target Neighborhood Hits	271	Shared Neighborhood Hits	5
SwissProt Accessions	P60370, Q70LJ3	Gene names	KRTAP10-5, KAP10.5, KAP18-5, KRTAP10.5, KRTAP18-5, KRTAP18.5
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 10-5 (Keratin-associated protein 10.5) (High sulfur keratin-associated protein 10.5) (Keratin-associated protein 18-5) (Keratin-associated protein 18.5).