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Network neighborhood for query Sequence : IRF5_MOUSE

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IRF5_MOUSE
SwissProt Accessions	P56477	Gene names	Irf5
Domain Architecture
Description	Interferon regulatory factor 5 (IRF-5).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

IRF5_HUMAN
θ value	0 (rank : 1)	NC score	0.995672 (rank : 2)
Query Neighborhood Hits	49	Target Neighborhood Hits	41	Shared Neighborhood Hits	22
SwissProt Accessions	Q13568, Q9BQF0	Gene names	IRF5
Domain Architecture
Description	Interferon regulatory factor 5 (IRF-5).

IRF5_MOUSE
θ value	0 (rank : 2)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	49	Target Neighborhood Hits	49	Shared Neighborhood Hits	49
SwissProt Accessions	P56477	Gene names	Irf5
Domain Architecture
Description	Interferon regulatory factor 5 (IRF-5).

IRF6_MOUSE
θ value	1.63515e-126 (rank : 3)	NC score	0.983668 (rank : 3)
Query Neighborhood Hits	49	Target Neighborhood Hits	26	Shared Neighborhood Hits	18
SwissProt Accessions	P97431	Gene names	Irf6
Domain Architecture
Description	Interferon regulatory factor 6 (IRF-6).

IRF6_HUMAN
θ value	3.08376e-125 (rank : 4)	NC score	0.983283 (rank : 4)
Query Neighborhood Hits	49	Target Neighborhood Hits	30	Shared Neighborhood Hits	18
SwissProt Accessions	O14896	Gene names	IRF6
Domain Architecture
Description	Interferon regulatory factor 6 (IRF-6).

IRF4_HUMAN
θ value	2.7521e-57 (rank : 5)	NC score	0.930214 (rank : 6)
Query Neighborhood Hits	49	Target Neighborhood Hits	31	Shared Neighborhood Hits	18
SwissProt Accessions	Q15306, Q99660	Gene names	IRF4, MUM1
Domain Architecture
Description	Interferon regulatory factor 4 (IRF-4) (Lymphocyte-specific interferon regulatory factor) (LSIRF) (NF-EM5) (Multiple myeloma oncogene 1).

IRF4_MOUSE
θ value	3.974e-56 (rank : 6)	NC score	0.930930 (rank : 5)
Query Neighborhood Hits	49	Target Neighborhood Hits	27	Shared Neighborhood Hits	18
SwissProt Accessions	Q64287, Q60802	Gene names	Irf4, Spip
Domain Architecture
Description	Interferon regulatory factor 4 (IRF-4) (Lymphocyte-specific interferon regulatory factor) (LSIRF) (NF-EM5) (PU.1 interaction partner) (Transcriptional activator PIP).

IRF8_HUMAN
θ value	3.71957e-54 (rank : 7)	NC score	0.926846 (rank : 7)
Query Neighborhood Hits	49	Target Neighborhood Hits	25	Shared Neighborhood Hits	18
SwissProt Accessions	Q02556	Gene names	IRF8, ICSBP1
Domain Architecture
Description	Interferon regulatory factor 8 (IRF-8) (Interferon consensus sequence- binding protein) (ICSBP).

IRF8_MOUSE
θ value	3.1488e-53 (rank : 8)	NC score	0.924206 (rank : 8)
Query Neighborhood Hits	49	Target Neighborhood Hits	31	Shared Neighborhood Hits	18
SwissProt Accessions	P23611	Gene names	Irf8, Icsbp, Icsbp1
Domain Architecture
Description	Interferon regulatory factor 8 (IRF-8) (Interferon consensus sequence- binding protein) (ICSBP).

IRF3_HUMAN
θ value	5.38352e-45 (rank : 9)	NC score	0.900261 (rank : 10)
Query Neighborhood Hits	49	Target Neighborhood Hits	129	Shared Neighborhood Hits	19
SwissProt Accessions	Q14653	Gene names	IRF3
Domain Architecture
Description	Interferon regulatory factor 3 (IRF-3).

IRF3_MOUSE
θ value	4.88048e-38 (rank : 10)	NC score	0.902641 (rank : 9)
Query Neighborhood Hits	49	Target Neighborhood Hits	25	Shared Neighborhood Hits	18
SwissProt Accessions	P70671	Gene names	Irf3
Domain Architecture
Description	Interferon regulatory factor 3 (IRF-3).

IRF7_HUMAN
θ value	2.50655e-34 (rank : 11)	NC score	0.881091 (rank : 13)
Query Neighborhood Hits	49	Target Neighborhood Hits	73	Shared Neighborhood Hits	21
SwissProt Accessions	Q92985, O00331, O00332, O00333, O75924	Gene names	IRF7
Domain Architecture
Description	Interferon regulatory factor 7 (IRF-7).

IRF7_MOUSE
θ value	3.27365e-34 (rank : 12)	NC score	0.894929 (rank : 11)
Query Neighborhood Hits	49	Target Neighborhood Hits	34	Shared Neighborhood Hits	18
SwissProt Accessions	P70434	Gene names	Irf7
Domain Architecture
Description	Interferon regulatory factor 7 (IRF-7).

IRTF_HUMAN
θ value	2.12192e-33 (rank : 13)	NC score	0.891904 (rank : 12)
Query Neighborhood Hits	49	Target Neighborhood Hits	41	Shared Neighborhood Hits	18
SwissProt Accessions	Q00978	Gene names	ISGF3G, IRF9
Domain Architecture
Description	Transcriptional regulator ISGF3 subunit gamma (Interferon regulatory factor 9) (IRF-9) (IFN-alpha-responsive transcription factor subunit) (Interferon-stimulated gene factor 3 gamma) (ISGF3 p48 subunit) (ISGF- 3 gamma).

IRF2_HUMAN
θ value	8.08199e-25 (rank : 14)	NC score	0.838899 (rank : 17)
Query Neighborhood Hits	49	Target Neighborhood Hits	35	Shared Neighborhood Hits	18
SwissProt Accessions	P14316, Q96B99	Gene names	IRF2
Domain Architecture
Description	Interferon regulatory factor 2 (IRF-2).

IRF2_MOUSE
θ value	1.05554e-24 (rank : 15)	NC score	0.835749 (rank : 18)
Query Neighborhood Hits	49	Target Neighborhood Hits	49	Shared Neighborhood Hits	18
SwissProt Accessions	P23906	Gene names	Irf2
Domain Architecture
Description	Interferon regulatory factor 2 (IRF-2).

IRF1_HUMAN
θ value	8.93572e-24 (rank : 16)	NC score	0.842592 (rank : 15)
Query Neighborhood Hits	49	Target Neighborhood Hits	26	Shared Neighborhood Hits	18
SwissProt Accessions	P10914, Q96GG7	Gene names	IRF1
Domain Architecture
Description	Interferon regulatory factor 1 (IRF-1).

IRF1_MOUSE
θ value	8.93572e-24 (rank : 17)	NC score	0.839181 (rank : 16)
Query Neighborhood Hits	49	Target Neighborhood Hits	27	Shared Neighborhood Hits	18
SwissProt Accessions	P15314	Gene names	Irf1
Domain Architecture
Description	Interferon regulatory factor 1 (IRF-1).

IRTF_MOUSE
θ value	4.58923e-20 (rank : 18)	NC score	0.861097 (rank : 14)
Query Neighborhood Hits	49	Target Neighborhood Hits	26	Shared Neighborhood Hits	18
SwissProt Accessions	Q61179	Gene names	Isgf3g
Domain Architecture
Description	Transcriptional regulator ISGF3 subunit gamma (IFN-alpha-responsive transcription factor subunit) (Interferon-stimulated gene factor 3 gamma) (ISGF3 p48 subunit) (ISGF-3 gamma).

GNAS1_MOUSE
θ value	0.163984 (rank : 19)	NC score	0.012329 (rank : 28)
Query Neighborhood Hits	49	Target Neighborhood Hits	651	Shared Neighborhood Hits	8
SwissProt Accessions	Q6R0H7, Q6R0H4, Q6R0H5, Q6R2J5, Q9JJX0, Q9Z1N8	Gene names	Gnas, Gnas1
Domain Architecture	No domain graphic available
Description	Guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas (Adenylate cyclase-stimulating G alpha protein) (Extra large alphas protein) (XLalphas).

PLXB3_HUMAN
θ value	0.47712 (rank : 20)	NC score	0.011288 (rank : 31)
Query Neighborhood Hits	49	Target Neighborhood Hits	106	Shared Neighborhood Hits	2
SwissProt Accessions	Q9ULL4, Q9HDA4	Gene names	PLXNB3, KIAA1206
Domain Architecture	No domain graphic available
Description	Plexin-B3 precursor.

RPGF3_HUMAN
θ value	0.47712 (rank : 21)	NC score	0.024673 (rank : 19)
Query Neighborhood Hits	49	Target Neighborhood Hits	56	Shared Neighborhood Hits	3
SwissProt Accessions	O95398, O95634, Q8WVN0	Gene names	RAPGEF3, CGEF1, EPAC, EPAC1
Domain Architecture
Description	Rap guanine nucleotide exchange factor 3 (cAMP-regulated guanine nucleotide exchange factor I) (cAMP-GEFI) (Exchange factor directly activated by cAMP 1) (Epac 1) (Rap1 guanine-nucleotide-exchange factor directly activated by cAMP).

RPGF3_MOUSE
θ value	0.62314 (rank : 22)	NC score	0.024491 (rank : 20)
Query Neighborhood Hits	49	Target Neighborhood Hits	54	Shared Neighborhood Hits	3
SwissProt Accessions	Q8VCC8, Q8BZK9, Q8R1R1	Gene names	Rapgef3, Epac, Epac1
Domain Architecture
Description	Rap guanine nucleotide exchange factor 3 (cAMP-regulated guanine nucleotide exchange factor I) (cAMP-GEFI) (Exchange factor directly activated by cAMP 1) (Epac 1).

ZN692_HUMAN
θ value	0.813845 (rank : 23)	NC score	0.000313 (rank : 47)
Query Neighborhood Hits	49	Target Neighborhood Hits	808	Shared Neighborhood Hits	4
SwissProt Accessions	Q9BU19, Q5SRA5, Q5SRA6, Q9HBC9, Q9NW93, Q9NWY6, Q9UF97	Gene names	ZNF692
Domain Architecture	No domain graphic available
Description	Zinc finger protein 692.

SSBP4_HUMAN
θ value	1.06291 (rank : 24)	NC score	0.012210 (rank : 29)
Query Neighborhood Hits	49	Target Neighborhood Hits	753	Shared Neighborhood Hits	8
SwissProt Accessions	Q9BWG4	Gene names	SSBP4
Domain Architecture
Description	Single-stranded DNA-binding protein 4.

SON_HUMAN
θ value	1.38821 (rank : 25)	NC score	0.012441 (rank : 27)
Query Neighborhood Hits	49	Target Neighborhood Hits	1568	Shared Neighborhood Hits	14
SwissProt Accessions	P18583, O14487, O95981, Q14120, Q9H7B1, Q9P070, Q9P072, Q9UKP9, Q9UPY0	Gene names	SON, C21orf50, DBP5, KIAA1019, NREBP
Domain Architecture
Description	SON protein (SON3) (Negative regulatory element-binding protein) (NRE- binding protein) (DBP-5) (Bax antagonist selected in saccharomyces 1) (BASS1).

MNT_HUMAN
θ value	1.81305 (rank : 26)	NC score	0.015682 (rank : 24)
Query Neighborhood Hits	49	Target Neighborhood Hits	496	Shared Neighborhood Hits	7
SwissProt Accessions	Q99583	Gene names	MNT, ROX
Domain Architecture
Description	Max-binding protein MNT (Protein ROX) (Myc antagonist MNT).

PIGT_HUMAN
θ value	2.36792 (rank : 27)	NC score	0.018335 (rank : 21)
Query Neighborhood Hits	49	Target Neighborhood Hits	8	Shared Neighborhood Hits	2
SwissProt Accessions	Q969N2, Q7Z3N7, Q9BQY7, Q9BQY8, Q9UJG6, Q9Y2Z5	Gene names	PIGT
Domain Architecture
Description	GPI transamidase component PIG-T precursor (Phosphatidylinositol- glycan biosynthesis class T protein).

PO121_HUMAN
θ value	2.36792 (rank : 28)	NC score	0.018012 (rank : 22)
Query Neighborhood Hits	49	Target Neighborhood Hits	344	Shared Neighborhood Hits	10
SwissProt Accessions	Q9Y2N3, O75115, Q9Y4S7	Gene names	POM121, KIAA0618, NUP121
Domain Architecture	No domain graphic available
Description	Nuclear envelope pore membrane protein POM 121 (Pore membrane protein of 121 kDa) (P145).

ACK1_MOUSE
θ value	3.0926 (rank : 29)	NC score	-0.000963 (rank : 49)
Query Neighborhood Hits	49	Target Neighborhood Hits	1080	Shared Neighborhood Hits	6
SwissProt Accessions	O54967, Q8C2U0, Q8K0K4	Gene names	Tnk2, Ack1
Domain Architecture
Description	Activated CDC42 kinase 1 (EC 2.7.10.2) (ACK-1) (Non-receptor protein tyrosine kinase Ack) (Tyrosine kinase non-receptor protein 2).

DEN1A_HUMAN
θ value	3.0926 (rank : 30)	NC score	0.013866 (rank : 25)
Query Neighborhood Hits	49	Target Neighborhood Hits	176	Shared Neighborhood Hits	5
SwissProt Accessions	Q8TEH3, Q5VWF0, Q8IVD6, Q9H796	Gene names	DENND1A
Domain Architecture	No domain graphic available
Description	DENN domain-containing protein 1A.

TLE1_HUMAN
θ value	3.0926 (rank : 31)	NC score	0.009553 (rank : 33)
Query Neighborhood Hits	49	Target Neighborhood Hits	485	Shared Neighborhood Hits	5
SwissProt Accessions	Q04724, Q5T3G4, Q969V9	Gene names	TLE1
Domain Architecture
Description	Transducin-like enhancer protein 1 (ESG1) (E(Sp1) homolog).

TLE1_MOUSE
θ value	3.0926 (rank : 32)	NC score	0.009252 (rank : 34)
Query Neighborhood Hits	49	Target Neighborhood Hits	491	Shared Neighborhood Hits	5
SwissProt Accessions	Q62440	Gene names	Tle1, Grg1
Domain Architecture
Description	Transducin-like enhancer protein 1 (Groucho-related protein 1) (Grg- 1).

MTSS1_MOUSE
θ value	4.03905 (rank : 33)	NC score	0.016516 (rank : 23)
Query Neighborhood Hits	49	Target Neighborhood Hits	592	Shared Neighborhood Hits	8
SwissProt Accessions	Q8R1S4, Q8BMM3, Q99LB3	Gene names	Mtss1, Mim
Domain Architecture	No domain graphic available
Description	Metastasis suppressor protein 1 (Missing in metastasis protein).

DPOE2_HUMAN
θ value	5.27518 (rank : 34)	NC score	0.012593 (rank : 26)
Query Neighborhood Hits	49	Target Neighborhood Hits	9	Shared Neighborhood Hits	2
SwissProt Accessions	P56282, O43560	Gene names	POLE2, DPE2
Domain Architecture
Description	DNA polymerase epsilon subunit 2 (EC 2.7.7.7) (DNA polymerase II subunit 2) (DNA polymerase epsilon subunit B).

NALP6_HUMAN
θ value	5.27518 (rank : 35)	NC score	0.005679 (rank : 44)
Query Neighborhood Hits	49	Target Neighborhood Hits	52	Shared Neighborhood Hits	2
SwissProt Accessions	P59044	Gene names	NALP6, PYPAF5
Domain Architecture
Description	NACHT, LRR and PYD-containing protein 6 (PYRIN-containing APAF1-like protein 5).

SEZ6L_HUMAN
θ value	5.27518 (rank : 36)	NC score	0.005939 (rank : 43)
Query Neighborhood Hits	49	Target Neighborhood Hits	289	Shared Neighborhood Hits	5
SwissProt Accessions	Q9BYH1, O95917, Q5THY5, Q6IBZ4, Q6UXD4, Q9NUI3, Q9NUI4, Q9NUI5, Q9Y2E1, Q9Y3J6	Gene names	SEZ6L, KIAA0927
Domain Architecture
Description	Seizure 6-like protein precursor.

XYLT1_HUMAN
θ value	5.27518 (rank : 37)	NC score	0.008307 (rank : 39)
Query Neighborhood Hits	49	Target Neighborhood Hits	87	Shared Neighborhood Hits	2
SwissProt Accessions	Q86Y38, Q9H1B6	Gene names	XYLT1, XT1
Domain Architecture	No domain graphic available
Description	Xylosyltransferase 1 (EC 2.4.2.26) (Xylosyltransferase I) (XylT-I) (XT-I) (Peptide O-xylosyltransferase 1).

ZMYM3_MOUSE
θ value	5.27518 (rank : 38)	NC score	0.008439 (rank : 37)
Query Neighborhood Hits	49	Target Neighborhood Hits	177	Shared Neighborhood Hits	4
SwissProt Accessions	Q9JLM4, Q80U17	Gene names	Zmym3, Kiaa0385, Zfp261, Znf261
Domain Architecture	No domain graphic available
Description	Zinc finger MYM-type protein 3 (Zinc finger protein 261) (DXHXS6673E protein).

BIM_MOUSE
θ value	6.88961 (rank : 39)	NC score	0.011481 (rank : 30)
Query Neighborhood Hits	49	Target Neighborhood Hits	124	Shared Neighborhood Hits	2
SwissProt Accessions	O54918, O54919, O54920	Gene names	Bcl2l11, Bim
Domain Architecture
Description	Bcl-2-like protein 11 (Bcl2-interacting mediator of cell death).

ENPP7_HUMAN
θ value	6.88961 (rank : 40)	NC score	0.007238 (rank : 40)
Query Neighborhood Hits	49	Target Neighborhood Hits	30	Shared Neighborhood Hits	2
SwissProt Accessions	Q6UWV6, Q6ZTS5, Q8IUS8	Gene names	ENPP7
Domain Architecture	No domain graphic available
Description	Ectonucleotide pyrophosphatase/phosphodiesterase 7 precursor (EC 3.1.4.12) (E-NPP7) (NPP-7) (Alkaline sphingomyelin phosphodiesterase) (Intestinal alkaline sphingomyelinase) (Alk-SMase).

SAPS1_HUMAN
θ value	6.88961 (rank : 41)	NC score	0.008316 (rank : 38)
Query Neighborhood Hits	49	Target Neighborhood Hits	704	Shared Neighborhood Hits	9
SwissProt Accessions	Q9UPN7, Q504V2, Q6NVJ6, Q9BU97	Gene names	SAPS1, KIAA1115
Domain Architecture
Description	SAPS domain family member 1.

TMEPA_HUMAN
θ value	6.88961 (rank : 42)	NC score	0.008945 (rank : 36)
Query Neighborhood Hits	49	Target Neighborhood Hits	46	Shared Neighborhood Hits	2
SwissProt Accessions	Q969W9, Q5TDR6, Q96B72, Q9UJD3	Gene names	TMEPAI, PMEPA1, STAG1
Domain Architecture
Description	Transmembrane prostate androgen-induced protein (Solid tumor- associated 1 protein).

CNTRB_MOUSE
θ value	8.99809 (rank : 43)	NC score	0.000067 (rank : 48)
Query Neighborhood Hits	49	Target Neighborhood Hits	1029	Shared Neighborhood Hits	4
SwissProt Accessions	Q8CB62, Q5NCF3	Gene names	Cntrob, Lip8
Domain Architecture	No domain graphic available
Description	Centrobin (LYST-interacting protein 8).

ECM1_MOUSE
θ value	8.99809 (rank : 44)	NC score	0.009164 (rank : 35)
Query Neighborhood Hits	49	Target Neighborhood Hits	105	Shared Neighborhood Hits	4
SwissProt Accessions	Q61508	Gene names	Ecm1
Domain Architecture
Description	Extracellular matrix protein 1 precursor (Secretory component p85).

MDFI_HUMAN
θ value	8.99809 (rank : 45)	NC score	0.011140 (rank : 32)
Query Neighborhood Hits	49	Target Neighborhood Hits	45	Shared Neighborhood Hits	2
SwissProt Accessions	Q99750	Gene names	MDFI
Domain Architecture	No domain graphic available
Description	MyoD family inhibitor (Myogenic repressor I-mf).

PHC2_MOUSE
θ value	8.99809 (rank : 46)	NC score	0.006636 (rank : 42)
Query Neighborhood Hits	49	Target Neighborhood Hits	156	Shared Neighborhood Hits	7
SwissProt Accessions	Q9QWH1, O88463, Q8K5D9	Gene names	Phc2, Edr2, Ph2
Domain Architecture	No domain graphic available
Description	Polyhomeotic-like protein 2 (mPH2) (Early development regulatory protein 2) (p36).

SOX21_HUMAN
θ value	8.99809 (rank : 47)	NC score	0.003991 (rank : 45)
Query Neighborhood Hits	49	Target Neighborhood Hits	89	Shared Neighborhood Hits	3
SwissProt Accessions	Q9Y651, P35715, Q15504	Gene names	SOX21, SOX25, SOXA
Domain Architecture
Description	Transcription factor SOX-21 (SOX-A).

SOX21_MOUSE
θ value	8.99809 (rank : 48)	NC score	0.003989 (rank : 46)
Query Neighborhood Hits	49	Target Neighborhood Hits	90	Shared Neighborhood Hits	3
SwissProt Accessions	Q811W0, Q8VH35	Gene names	Sox21
Domain Architecture	No domain graphic available
Description	Transcription factor SOX-21.

SYNG_HUMAN
θ value	8.99809 (rank : 49)	NC score	0.007059 (rank : 41)
Query Neighborhood Hits	49	Target Neighborhood Hits	160	Shared Neighborhood Hits	3
SwissProt Accessions	Q9UMZ2, Q6ZT17	Gene names	AP1GBP1, SYNG
Domain Architecture	No domain graphic available
Description	AP1 subunit gamma-binding protein 1 (Gamma-synergin).

Hits sorted by NC score

IRF5_MOUSE
NC score	0.999962 (rank : 1)	θ value	0 (rank : 2)
Query Neighborhood Hits	49	Target Neighborhood Hits	49	Shared Neighborhood Hits	49
SwissProt Accessions	P56477	Gene names	Irf5
Domain Architecture
Description	Interferon regulatory factor 5 (IRF-5).

IRF5_HUMAN
NC score	0.995672 (rank : 2)	θ value	0 (rank : 1)
Query Neighborhood Hits	49	Target Neighborhood Hits	41	Shared Neighborhood Hits	22
SwissProt Accessions	Q13568, Q9BQF0	Gene names	IRF5
Domain Architecture
Description	Interferon regulatory factor 5 (IRF-5).

IRF6_MOUSE
NC score	0.983668 (rank : 3)	θ value	1.63515e-126 (rank : 3)
Query Neighborhood Hits	49	Target Neighborhood Hits	26	Shared Neighborhood Hits	18
SwissProt Accessions	P97431	Gene names	Irf6
Domain Architecture
Description	Interferon regulatory factor 6 (IRF-6).

IRF6_HUMAN
NC score	0.983283 (rank : 4)	θ value	3.08376e-125 (rank : 4)
Query Neighborhood Hits	49	Target Neighborhood Hits	30	Shared Neighborhood Hits	18
SwissProt Accessions	O14896	Gene names	IRF6
Domain Architecture
Description	Interferon regulatory factor 6 (IRF-6).

IRF4_MOUSE
NC score	0.930930 (rank : 5)	θ value	3.974e-56 (rank : 6)
Query Neighborhood Hits	49	Target Neighborhood Hits	27	Shared Neighborhood Hits	18
SwissProt Accessions	Q64287, Q60802	Gene names	Irf4, Spip
Domain Architecture
Description	Interferon regulatory factor 4 (IRF-4) (Lymphocyte-specific interferon regulatory factor) (LSIRF) (NF-EM5) (PU.1 interaction partner) (Transcriptional activator PIP).

IRF4_HUMAN
NC score	0.930214 (rank : 6)	θ value	2.7521e-57 (rank : 5)
Query Neighborhood Hits	49	Target Neighborhood Hits	31	Shared Neighborhood Hits	18
SwissProt Accessions	Q15306, Q99660	Gene names	IRF4, MUM1
Domain Architecture
Description	Interferon regulatory factor 4 (IRF-4) (Lymphocyte-specific interferon regulatory factor) (LSIRF) (NF-EM5) (Multiple myeloma oncogene 1).

IRF8_HUMAN
NC score	0.926846 (rank : 7)	θ value	3.71957e-54 (rank : 7)
Query Neighborhood Hits	49	Target Neighborhood Hits	25	Shared Neighborhood Hits	18
SwissProt Accessions	Q02556	Gene names	IRF8, ICSBP1
Domain Architecture
Description	Interferon regulatory factor 8 (IRF-8) (Interferon consensus sequence- binding protein) (ICSBP).

IRF8_MOUSE
NC score	0.924206 (rank : 8)	θ value	3.1488e-53 (rank : 8)
Query Neighborhood Hits	49	Target Neighborhood Hits	31	Shared Neighborhood Hits	18
SwissProt Accessions	P23611	Gene names	Irf8, Icsbp, Icsbp1
Domain Architecture
Description	Interferon regulatory factor 8 (IRF-8) (Interferon consensus sequence- binding protein) (ICSBP).

IRF3_MOUSE
NC score	0.902641 (rank : 9)	θ value	4.88048e-38 (rank : 10)
Query Neighborhood Hits	49	Target Neighborhood Hits	25	Shared Neighborhood Hits	18
SwissProt Accessions	P70671	Gene names	Irf3
Domain Architecture
Description	Interferon regulatory factor 3 (IRF-3).

IRF3_HUMAN
NC score	0.900261 (rank : 10)	θ value	5.38352e-45 (rank : 9)
Query Neighborhood Hits	49	Target Neighborhood Hits	129	Shared Neighborhood Hits	19
SwissProt Accessions	Q14653	Gene names	IRF3
Domain Architecture
Description	Interferon regulatory factor 3 (IRF-3).

IRF7_MOUSE
NC score	0.894929 (rank : 11)	θ value	3.27365e-34 (rank : 12)
Query Neighborhood Hits	49	Target Neighborhood Hits	34	Shared Neighborhood Hits	18
SwissProt Accessions	P70434	Gene names	Irf7
Domain Architecture
Description	Interferon regulatory factor 7 (IRF-7).

IRTF_HUMAN
NC score	0.891904 (rank : 12)	θ value	2.12192e-33 (rank : 13)
Query Neighborhood Hits	49	Target Neighborhood Hits	41	Shared Neighborhood Hits	18
SwissProt Accessions	Q00978	Gene names	ISGF3G, IRF9
Domain Architecture
Description	Transcriptional regulator ISGF3 subunit gamma (Interferon regulatory factor 9) (IRF-9) (IFN-alpha-responsive transcription factor subunit) (Interferon-stimulated gene factor 3 gamma) (ISGF3 p48 subunit) (ISGF- 3 gamma).

IRF7_HUMAN
NC score	0.881091 (rank : 13)	θ value	2.50655e-34 (rank : 11)
Query Neighborhood Hits	49	Target Neighborhood Hits	73	Shared Neighborhood Hits	21
SwissProt Accessions	Q92985, O00331, O00332, O00333, O75924	Gene names	IRF7
Domain Architecture
Description	Interferon regulatory factor 7 (IRF-7).

IRTF_MOUSE
NC score	0.861097 (rank : 14)	θ value	4.58923e-20 (rank : 18)
Query Neighborhood Hits	49	Target Neighborhood Hits	26	Shared Neighborhood Hits	18
SwissProt Accessions	Q61179	Gene names	Isgf3g
Domain Architecture
Description	Transcriptional regulator ISGF3 subunit gamma (IFN-alpha-responsive transcription factor subunit) (Interferon-stimulated gene factor 3 gamma) (ISGF3 p48 subunit) (ISGF-3 gamma).

IRF1_HUMAN
NC score	0.842592 (rank : 15)	θ value	8.93572e-24 (rank : 16)
Query Neighborhood Hits	49	Target Neighborhood Hits	26	Shared Neighborhood Hits	18
SwissProt Accessions	P10914, Q96GG7	Gene names	IRF1
Domain Architecture
Description	Interferon regulatory factor 1 (IRF-1).

IRF1_MOUSE
NC score	0.839181 (rank : 16)	θ value	8.93572e-24 (rank : 17)
Query Neighborhood Hits	49	Target Neighborhood Hits	27	Shared Neighborhood Hits	18
SwissProt Accessions	P15314	Gene names	Irf1
Domain Architecture
Description	Interferon regulatory factor 1 (IRF-1).

IRF2_HUMAN
NC score	0.838899 (rank : 17)	θ value	8.08199e-25 (rank : 14)
Query Neighborhood Hits	49	Target Neighborhood Hits	35	Shared Neighborhood Hits	18
SwissProt Accessions	P14316, Q96B99	Gene names	IRF2
Domain Architecture
Description	Interferon regulatory factor 2 (IRF-2).

IRF2_MOUSE
NC score	0.835749 (rank : 18)	θ value	1.05554e-24 (rank : 15)
Query Neighborhood Hits	49	Target Neighborhood Hits	49	Shared Neighborhood Hits	18
SwissProt Accessions	P23906	Gene names	Irf2
Domain Architecture
Description	Interferon regulatory factor 2 (IRF-2).

RPGF3_HUMAN
NC score	0.024673 (rank : 19)	θ value	0.47712 (rank : 21)
Query Neighborhood Hits	49	Target Neighborhood Hits	56	Shared Neighborhood Hits	3
SwissProt Accessions	O95398, O95634, Q8WVN0	Gene names	RAPGEF3, CGEF1, EPAC, EPAC1
Domain Architecture
Description	Rap guanine nucleotide exchange factor 3 (cAMP-regulated guanine nucleotide exchange factor I) (cAMP-GEFI) (Exchange factor directly activated by cAMP 1) (Epac 1) (Rap1 guanine-nucleotide-exchange factor directly activated by cAMP).

RPGF3_MOUSE
NC score	0.024491 (rank : 20)	θ value	0.62314 (rank : 22)
Query Neighborhood Hits	49	Target Neighborhood Hits	54	Shared Neighborhood Hits	3
SwissProt Accessions	Q8VCC8, Q8BZK9, Q8R1R1	Gene names	Rapgef3, Epac, Epac1
Domain Architecture
Description	Rap guanine nucleotide exchange factor 3 (cAMP-regulated guanine nucleotide exchange factor I) (cAMP-GEFI) (Exchange factor directly activated by cAMP 1) (Epac 1).

PIGT_HUMAN
NC score	0.018335 (rank : 21)	θ value	2.36792 (rank : 27)
Query Neighborhood Hits	49	Target Neighborhood Hits	8	Shared Neighborhood Hits	2
SwissProt Accessions	Q969N2, Q7Z3N7, Q9BQY7, Q9BQY8, Q9UJG6, Q9Y2Z5	Gene names	PIGT
Domain Architecture
Description	GPI transamidase component PIG-T precursor (Phosphatidylinositol- glycan biosynthesis class T protein).

PO121_HUMAN
NC score	0.018012 (rank : 22)	θ value	2.36792 (rank : 28)
Query Neighborhood Hits	49	Target Neighborhood Hits	344	Shared Neighborhood Hits	10
SwissProt Accessions	Q9Y2N3, O75115, Q9Y4S7	Gene names	POM121, KIAA0618, NUP121
Domain Architecture	No domain graphic available
Description	Nuclear envelope pore membrane protein POM 121 (Pore membrane protein of 121 kDa) (P145).

MTSS1_MOUSE
NC score	0.016516 (rank : 23)	θ value	4.03905 (rank : 33)
Query Neighborhood Hits	49	Target Neighborhood Hits	592	Shared Neighborhood Hits	8
SwissProt Accessions	Q8R1S4, Q8BMM3, Q99LB3	Gene names	Mtss1, Mim
Domain Architecture	No domain graphic available
Description	Metastasis suppressor protein 1 (Missing in metastasis protein).

MNT_HUMAN
NC score	0.015682 (rank : 24)	θ value	1.81305 (rank : 26)
Query Neighborhood Hits	49	Target Neighborhood Hits	496	Shared Neighborhood Hits	7
SwissProt Accessions	Q99583	Gene names	MNT, ROX
Domain Architecture
Description	Max-binding protein MNT (Protein ROX) (Myc antagonist MNT).

DEN1A_HUMAN
NC score	0.013866 (rank : 25)	θ value	3.0926 (rank : 30)
Query Neighborhood Hits	49	Target Neighborhood Hits	176	Shared Neighborhood Hits	5
SwissProt Accessions	Q8TEH3, Q5VWF0, Q8IVD6, Q9H796	Gene names	DENND1A
Domain Architecture	No domain graphic available
Description	DENN domain-containing protein 1A.

DPOE2_HUMAN
NC score	0.012593 (rank : 26)	θ value	5.27518 (rank : 34)
Query Neighborhood Hits	49	Target Neighborhood Hits	9	Shared Neighborhood Hits	2
SwissProt Accessions	P56282, O43560	Gene names	POLE2, DPE2
Domain Architecture
Description	DNA polymerase epsilon subunit 2 (EC 2.7.7.7) (DNA polymerase II subunit 2) (DNA polymerase epsilon subunit B).

SON_HUMAN
NC score	0.012441 (rank : 27)	θ value	1.38821 (rank : 25)
Query Neighborhood Hits	49	Target Neighborhood Hits	1568	Shared Neighborhood Hits	14
SwissProt Accessions	P18583, O14487, O95981, Q14120, Q9H7B1, Q9P070, Q9P072, Q9UKP9, Q9UPY0	Gene names	SON, C21orf50, DBP5, KIAA1019, NREBP
Domain Architecture
Description	SON protein (SON3) (Negative regulatory element-binding protein) (NRE- binding protein) (DBP-5) (Bax antagonist selected in saccharomyces 1) (BASS1).

GNAS1_MOUSE
NC score	0.012329 (rank : 28)	θ value	0.163984 (rank : 19)
Query Neighborhood Hits	49	Target Neighborhood Hits	651	Shared Neighborhood Hits	8
SwissProt Accessions	Q6R0H7, Q6R0H4, Q6R0H5, Q6R2J5, Q9JJX0, Q9Z1N8	Gene names	Gnas, Gnas1
Domain Architecture	No domain graphic available
Description	Guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas (Adenylate cyclase-stimulating G alpha protein) (Extra large alphas protein) (XLalphas).

SSBP4_HUMAN
NC score	0.012210 (rank : 29)	θ value	1.06291 (rank : 24)
Query Neighborhood Hits	49	Target Neighborhood Hits	753	Shared Neighborhood Hits	8
SwissProt Accessions	Q9BWG4	Gene names	SSBP4
Domain Architecture
Description	Single-stranded DNA-binding protein 4.

BIM_MOUSE
NC score	0.011481 (rank : 30)	θ value	6.88961 (rank : 39)
Query Neighborhood Hits	49	Target Neighborhood Hits	124	Shared Neighborhood Hits	2
SwissProt Accessions	O54918, O54919, O54920	Gene names	Bcl2l11, Bim
Domain Architecture
Description	Bcl-2-like protein 11 (Bcl2-interacting mediator of cell death).

PLXB3_HUMAN
NC score	0.011288 (rank : 31)	θ value	0.47712 (rank : 20)
Query Neighborhood Hits	49	Target Neighborhood Hits	106	Shared Neighborhood Hits	2
SwissProt Accessions	Q9ULL4, Q9HDA4	Gene names	PLXNB3, KIAA1206
Domain Architecture	No domain graphic available
Description	Plexin-B3 precursor.

MDFI_HUMAN
NC score	0.011140 (rank : 32)	θ value	8.99809 (rank : 45)
Query Neighborhood Hits	49	Target Neighborhood Hits	45	Shared Neighborhood Hits	2
SwissProt Accessions	Q99750	Gene names	MDFI
Domain Architecture	No domain graphic available
Description	MyoD family inhibitor (Myogenic repressor I-mf).

TLE1_HUMAN
NC score	0.009553 (rank : 33)	θ value	3.0926 (rank : 31)
Query Neighborhood Hits	49	Target Neighborhood Hits	485	Shared Neighborhood Hits	5
SwissProt Accessions	Q04724, Q5T3G4, Q969V9	Gene names	TLE1
Domain Architecture
Description	Transducin-like enhancer protein 1 (ESG1) (E(Sp1) homolog).

TLE1_MOUSE
NC score	0.009252 (rank : 34)	θ value	3.0926 (rank : 32)
Query Neighborhood Hits	49	Target Neighborhood Hits	491	Shared Neighborhood Hits	5
SwissProt Accessions	Q62440	Gene names	Tle1, Grg1
Domain Architecture
Description	Transducin-like enhancer protein 1 (Groucho-related protein 1) (Grg- 1).

ECM1_MOUSE
NC score	0.009164 (rank : 35)	θ value	8.99809 (rank : 44)
Query Neighborhood Hits	49	Target Neighborhood Hits	105	Shared Neighborhood Hits	4
SwissProt Accessions	Q61508	Gene names	Ecm1
Domain Architecture
Description	Extracellular matrix protein 1 precursor (Secretory component p85).

TMEPA_HUMAN
NC score	0.008945 (rank : 36)	θ value	6.88961 (rank : 42)
Query Neighborhood Hits	49	Target Neighborhood Hits	46	Shared Neighborhood Hits	2
SwissProt Accessions	Q969W9, Q5TDR6, Q96B72, Q9UJD3	Gene names	TMEPAI, PMEPA1, STAG1
Domain Architecture
Description	Transmembrane prostate androgen-induced protein (Solid tumor- associated 1 protein).

ZMYM3_MOUSE
NC score	0.008439 (rank : 37)	θ value	5.27518 (rank : 38)
Query Neighborhood Hits	49	Target Neighborhood Hits	177	Shared Neighborhood Hits	4
SwissProt Accessions	Q9JLM4, Q80U17	Gene names	Zmym3, Kiaa0385, Zfp261, Znf261
Domain Architecture	No domain graphic available
Description	Zinc finger MYM-type protein 3 (Zinc finger protein 261) (DXHXS6673E protein).

SAPS1_HUMAN
NC score	0.008316 (rank : 38)	θ value	6.88961 (rank : 41)
Query Neighborhood Hits	49	Target Neighborhood Hits	704	Shared Neighborhood Hits	9
SwissProt Accessions	Q9UPN7, Q504V2, Q6NVJ6, Q9BU97	Gene names	SAPS1, KIAA1115
Domain Architecture
Description	SAPS domain family member 1.

XYLT1_HUMAN
NC score	0.008307 (rank : 39)	θ value	5.27518 (rank : 37)
Query Neighborhood Hits	49	Target Neighborhood Hits	87	Shared Neighborhood Hits	2
SwissProt Accessions	Q86Y38, Q9H1B6	Gene names	XYLT1, XT1
Domain Architecture	No domain graphic available
Description	Xylosyltransferase 1 (EC 2.4.2.26) (Xylosyltransferase I) (XylT-I) (XT-I) (Peptide O-xylosyltransferase 1).

ENPP7_HUMAN
NC score	0.007238 (rank : 40)	θ value	6.88961 (rank : 40)
Query Neighborhood Hits	49	Target Neighborhood Hits	30	Shared Neighborhood Hits	2
SwissProt Accessions	Q6UWV6, Q6ZTS5, Q8IUS8	Gene names	ENPP7
Domain Architecture	No domain graphic available
Description	Ectonucleotide pyrophosphatase/phosphodiesterase 7 precursor (EC 3.1.4.12) (E-NPP7) (NPP-7) (Alkaline sphingomyelin phosphodiesterase) (Intestinal alkaline sphingomyelinase) (Alk-SMase).

SYNG_HUMAN
NC score	0.007059 (rank : 41)	θ value	8.99809 (rank : 49)
Query Neighborhood Hits	49	Target Neighborhood Hits	160	Shared Neighborhood Hits	3
SwissProt Accessions	Q9UMZ2, Q6ZT17	Gene names	AP1GBP1, SYNG
Domain Architecture	No domain graphic available
Description	AP1 subunit gamma-binding protein 1 (Gamma-synergin).

PHC2_MOUSE
NC score	0.006636 (rank : 42)	θ value	8.99809 (rank : 46)
Query Neighborhood Hits	49	Target Neighborhood Hits	156	Shared Neighborhood Hits	7
SwissProt Accessions	Q9QWH1, O88463, Q8K5D9	Gene names	Phc2, Edr2, Ph2
Domain Architecture	No domain graphic available
Description	Polyhomeotic-like protein 2 (mPH2) (Early development regulatory protein 2) (p36).

SEZ6L_HUMAN
NC score	0.005939 (rank : 43)	θ value	5.27518 (rank : 36)
Query Neighborhood Hits	49	Target Neighborhood Hits	289	Shared Neighborhood Hits	5
SwissProt Accessions	Q9BYH1, O95917, Q5THY5, Q6IBZ4, Q6UXD4, Q9NUI3, Q9NUI4, Q9NUI5, Q9Y2E1, Q9Y3J6	Gene names	SEZ6L, KIAA0927
Domain Architecture
Description	Seizure 6-like protein precursor.

NALP6_HUMAN
NC score	0.005679 (rank : 44)	θ value	5.27518 (rank : 35)
Query Neighborhood Hits	49	Target Neighborhood Hits	52	Shared Neighborhood Hits	2
SwissProt Accessions	P59044	Gene names	NALP6, PYPAF5
Domain Architecture
Description	NACHT, LRR and PYD-containing protein 6 (PYRIN-containing APAF1-like protein 5).

SOX21_HUMAN
NC score	0.003991 (rank : 45)	θ value	8.99809 (rank : 47)
Query Neighborhood Hits	49	Target Neighborhood Hits	89	Shared Neighborhood Hits	3
SwissProt Accessions	Q9Y651, P35715, Q15504	Gene names	SOX21, SOX25, SOXA
Domain Architecture
Description	Transcription factor SOX-21 (SOX-A).

SOX21_MOUSE
NC score	0.003989 (rank : 46)	θ value	8.99809 (rank : 48)
Query Neighborhood Hits	49	Target Neighborhood Hits	90	Shared Neighborhood Hits	3
SwissProt Accessions	Q811W0, Q8VH35	Gene names	Sox21
Domain Architecture	No domain graphic available
Description	Transcription factor SOX-21.

ZN692_HUMAN
NC score	0.000313 (rank : 47)	θ value	0.813845 (rank : 23)
Query Neighborhood Hits	49	Target Neighborhood Hits	808	Shared Neighborhood Hits	4
SwissProt Accessions	Q9BU19, Q5SRA5, Q5SRA6, Q9HBC9, Q9NW93, Q9NWY6, Q9UF97	Gene names	ZNF692
Domain Architecture	No domain graphic available
Description	Zinc finger protein 692.

CNTRB_MOUSE
NC score	0.000067 (rank : 48)	θ value	8.99809 (rank : 43)
Query Neighborhood Hits	49	Target Neighborhood Hits	1029	Shared Neighborhood Hits	4
SwissProt Accessions	Q8CB62, Q5NCF3	Gene names	Cntrob, Lip8
Domain Architecture	No domain graphic available
Description	Centrobin (LYST-interacting protein 8).

ACK1_MOUSE
NC score	-0.000963 (rank : 49)	θ value	3.0926 (rank : 29)
Query Neighborhood Hits	49	Target Neighborhood Hits	1080	Shared Neighborhood Hits	6
SwissProt Accessions	O54967, Q8C2U0, Q8K0K4	Gene names	Tnk2, Ack1
Domain Architecture
Description	Activated CDC42 kinase 1 (EC 2.7.10.2) (ACK-1) (Non-receptor protein tyrosine kinase Ack) (Tyrosine kinase non-receptor protein 2).