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Network neighborhood for query Sequence : MDFI_HUMAN

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MDFI_HUMAN
SwissProt Accessions	Q99750	Gene names	MDFI
Domain Architecture	No domain graphic available
Description	MyoD family inhibitor (Myogenic repressor I-mf).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

MDFI_HUMAN
θ value	1.64657e-102 (rank : 1)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	45	Target Neighborhood Hits	45	Shared Neighborhood Hits	45
SwissProt Accessions	Q99750	Gene names	MDFI
Domain Architecture	No domain graphic available
Description	MyoD family inhibitor (Myogenic repressor I-mf).

MDFI_MOUSE
θ value	7.51208e-47 (rank : 2)	NC score	0.901438 (rank : 2)
Query Neighborhood Hits	45	Target Neighborhood Hits	20	Shared Neighborhood Hits	3
SwissProt Accessions	P70331, P70330, P70332, Q99JM9	Gene names	Mdfi
Domain Architecture	No domain graphic available
Description	MyoD family inhibitor (Myogenic repressor I-mf).

PRG4_HUMAN
θ value	0.0961366 (rank : 3)	NC score	0.068116 (rank : 7)
Query Neighborhood Hits	45	Target Neighborhood Hits	764	Shared Neighborhood Hits	9
SwissProt Accessions	Q92954, Q6DNC4, Q6DNC5, Q6ZMZ5, Q9BX49	Gene names	PRG4, MSF, SZP
Domain Architecture	No domain graphic available
Description	Proteoglycan-4 precursor (Lubricin) (Megakaryocyte-stimulating factor) (Superficial zone proteoglycan) [Contains: Proteoglycan-4 C-terminal part].

MLL3_MOUSE
θ value	0.125558 (rank : 4)	NC score	0.052484 (rank : 19)
Query Neighborhood Hits	45	Target Neighborhood Hits	1399	Shared Neighborhood Hits	18
SwissProt Accessions	Q8BRH4, Q5YLV9, Q8BK12, Q8C6M3, Q923H5, Q923H6	Gene names	Mll3
Domain Architecture
Description	Myeloid/lymphoid or mixed-lineage leukemia protein 3 homolog (EC 2.1.1.43) (Histone-lysine N-methyltransferase, H3 lysine-4 specific MLL3).

OGFR_HUMAN
θ value	0.163984 (rank : 5)	NC score	0.066479 (rank : 9)
Query Neighborhood Hits	45	Target Neighborhood Hits	1582	Shared Neighborhood Hits	21
SwissProt Accessions	Q9NZT2, O96029, Q4VXW5, Q96CM2, Q9BQW1, Q9H4H0, Q9H7J5, Q9NZT3, Q9NZT4	Gene names	OGFR
Domain Architecture
Description	Opioid growth factor receptor (OGFr) (Zeta-type opioid receptor) (7-60 protein).

PIGQ_HUMAN
θ value	0.365318 (rank : 6)	NC score	0.074821 (rank : 3)
Query Neighborhood Hits	45	Target Neighborhood Hits	84	Shared Neighborhood Hits	3
SwissProt Accessions	Q9BRB3, O14927, Q96G00, Q96S22, Q9UJH4	Gene names	PIGQ, GPI1
Domain Architecture
Description	Phosphatidylinositol N-acetylglucosaminyltransferase subunit Q (EC 2.4.1.198) (Phosphatidylinositol-glycan biosynthesis class Q protein) (PIG-Q) (N-acetylglucosamyl transferase component GPI1).

COBA2_HUMAN
θ value	0.47712 (rank : 7)	NC score	0.068641 (rank : 6)
Query Neighborhood Hits	45	Target Neighborhood Hits	408	Shared Neighborhood Hits	9
SwissProt Accessions	P13942, Q07751, Q13271, Q13272, Q13273, Q99866, Q9UIP9	Gene names	COL11A2
Domain Architecture
Description	Collagen alpha-2(XI) chain precursor.

LRP5_HUMAN
θ value	0.47712 (rank : 8)	NC score	0.064547 (rank : 10)
Query Neighborhood Hits	45	Target Neighborhood Hits	224	Shared Neighborhood Hits	11
SwissProt Accessions	O75197, Q96TD6, Q9UP66	Gene names	LRP5, LRP7
Domain Architecture
Description	Low-density lipoprotein receptor-related protein 5 precursor.

COBA2_MOUSE
θ value	0.813845 (rank : 9)	NC score	0.066673 (rank : 8)
Query Neighborhood Hits	45	Target Neighborhood Hits	501	Shared Neighborhood Hits	12
SwissProt Accessions	Q64739, Q61432, Q9Z1W0	Gene names	Col11a2
Domain Architecture
Description	Collagen alpha-2(XI) chain precursor.

CSPG2_MOUSE
θ value	0.813845 (rank : 10)	NC score	0.027907 (rank : 29)
Query Neighborhood Hits	45	Target Neighborhood Hits	711	Shared Neighborhood Hits	9
SwissProt Accessions	Q62059, Q62058, Q9CUU0	Gene names	Cspg2
Domain Architecture
Description	Versican core protein precursor (Large fibroblast proteoglycan) (Chondroitin sulfate proteoglycan core protein 2) (PG-M).

CO5A1_HUMAN
θ value	1.06291 (rank : 11)	NC score	0.072849 (rank : 4)
Query Neighborhood Hits	45	Target Neighborhood Hits	434	Shared Neighborhood Hits	10
SwissProt Accessions	P20908, Q15094, Q5SUX4	Gene names	COL5A1
Domain Architecture
Description	Collagen alpha-1(V) chain precursor.

NECD_HUMAN
θ value	1.06291 (rank : 12)	NC score	0.027153 (rank : 30)
Query Neighborhood Hits	45	Target Neighborhood Hits	82	Shared Neighborhood Hits	3
SwissProt Accessions	Q99608	Gene names	NDN
Domain Architecture
Description	Necdin.

RGS3_HUMAN
θ value	1.06291 (rank : 13)	NC score	0.036754 (rank : 27)
Query Neighborhood Hits	45	Target Neighborhood Hits	1375	Shared Neighborhood Hits	17
SwissProt Accessions	P49796, Q5VXC1, Q5VZ05, Q6ZRM5, Q8IUQ1, Q8NC47, Q8NFN4, Q8NFN5, Q8TD59, Q8TD68, Q8WXA0	Gene names	RGS3
Domain Architecture
Description	Regulator of G-protein signaling 3 (RGS3) (RGP3).

COBA1_MOUSE
θ value	1.38821 (rank : 14)	NC score	0.064145 (rank : 12)
Query Neighborhood Hits	45	Target Neighborhood Hits	487	Shared Neighborhood Hits	11
SwissProt Accessions	Q61245, Q64047	Gene names	Col11a1
Domain Architecture
Description	Collagen alpha-1(XI) chain precursor.

LRP2_HUMAN
θ value	1.38821 (rank : 15)	NC score	0.048579 (rank : 22)
Query Neighborhood Hits	45	Target Neighborhood Hits	573	Shared Neighborhood Hits	16
SwissProt Accessions	P98164, O00711, Q16215	Gene names	LRP2
Domain Architecture
Description	Low-density lipoprotein receptor-related protein 2 precursor (Megalin) (Glycoprotein 330) (gp330).

PRG4_MOUSE
θ value	1.38821 (rank : 16)	NC score	0.061186 (rank : 14)
Query Neighborhood Hits	45	Target Neighborhood Hits	624	Shared Neighborhood Hits	8
SwissProt Accessions	Q9JM99, Q3UEL1, Q3V198	Gene names	Prg4, Msf, Szp
Domain Architecture	No domain graphic available
Description	Proteoglycan-4 precursor (Lubricin) (Megakaryocyte-stimulating factor) (Superficial zone proteoglycan) [Contains: Proteoglycan-4 C-terminal part].

BRSK1_HUMAN
θ value	1.81305 (rank : 17)	NC score	0.006733 (rank : 46)
Query Neighborhood Hits	45	Target Neighborhood Hits	942	Shared Neighborhood Hits	6
SwissProt Accessions	Q8TDC3, Q5J5B5, Q8NDD0, Q8NDR4, Q8TDC2, Q96AV4, Q96JL4	Gene names	BRSK1, KIAA1811, SAD1
Domain Architecture
Description	BR serine/threonine-protein kinase 1 (EC 2.7.11.1) (SAD1 kinase) (SAD1A).

CO5A1_MOUSE
θ value	1.81305 (rank : 18)	NC score	0.070899 (rank : 5)
Query Neighborhood Hits	45	Target Neighborhood Hits	419	Shared Neighborhood Hits	10
SwissProt Accessions	O88207	Gene names	Col5a1
Domain Architecture	No domain graphic available
Description	Collagen alpha-1(V) chain precursor.

CO8B_HUMAN
θ value	1.81305 (rank : 19)	NC score	0.054059 (rank : 17)
Query Neighborhood Hits	45	Target Neighborhood Hits	199	Shared Neighborhood Hits	10
SwissProt Accessions	P07358	Gene names	C8B
Domain Architecture
Description	Complement component C8 beta chain precursor (Complement component 8 subunit beta).

CO8B_MOUSE
θ value	1.81305 (rank : 20)	NC score	0.051480 (rank : 20)
Query Neighborhood Hits	45	Target Neighborhood Hits	224	Shared Neighborhood Hits	10
SwissProt Accessions	Q8BH35, Q4VAH1, Q8CHJ5, Q8CHJ6, Q8VC14	Gene names	C8b
Domain Architecture	No domain graphic available
Description	Complement component C8 beta chain precursor (Complement component 8 subunit beta).

COBA1_HUMAN
θ value	1.81305 (rank : 21)	NC score	0.064315 (rank : 11)
Query Neighborhood Hits	45	Target Neighborhood Hits	491	Shared Neighborhood Hits	12
SwissProt Accessions	P12107, Q14034, Q9UIT4, Q9UIT5, Q9UIT6	Gene names	COL11A1
Domain Architecture
Description	Collagen alpha-1(XI) chain precursor.

LRP5_MOUSE
θ value	1.81305 (rank : 22)	NC score	0.061736 (rank : 13)
Query Neighborhood Hits	45	Target Neighborhood Hits	236	Shared Neighborhood Hits	11
SwissProt Accessions	Q91VN0, O88883, Q9R208	Gene names	Lrp5, Lrp7
Domain Architecture
Description	Low-density lipoprotein receptor-related protein 5 precursor (LRP7) (Lr3).

UBXD2_MOUSE
θ value	1.81305 (rank : 23)	NC score	0.044482 (rank : 23)
Query Neighborhood Hits	45	Target Neighborhood Hits	183	Shared Neighborhood Hits	2
SwissProt Accessions	Q8VCH8, Q8BW17	Gene names	Ubxd2, Ubxdc1
Domain Architecture
Description	UBX domain-containing protein 2.

WNK2_HUMAN
θ value	1.81305 (rank : 24)	NC score	0.012220 (rank : 43)
Query Neighborhood Hits	45	Target Neighborhood Hits	1407	Shared Neighborhood Hits	11
SwissProt Accessions	Q9Y3S1, Q8IY36, Q9C0A3, Q9H3P4	Gene names	WNK2, KIAA1760, PRKWNK2
Domain Architecture
Description	Serine/threonine-protein kinase WNK2 (EC 2.7.11.1) (Protein kinase with no lysine 2) (Protein kinase, lysine-deficient 2).

CK024_HUMAN
θ value	2.36792 (rank : 25)	NC score	0.049782 (rank : 21)
Query Neighborhood Hits	45	Target Neighborhood Hits	408	Shared Neighborhood Hits	9
SwissProt Accessions	Q96F05, Q9H2K4	Gene names	C11orf24
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C11orf24 precursor (Protein DM4E3).

HTRA3_HUMAN
θ value	2.36792 (rank : 26)	NC score	0.040484 (rank : 24)
Query Neighborhood Hits	45	Target Neighborhood Hits	152	Shared Neighborhood Hits	5
SwissProt Accessions	P83110, Q7Z7A2	Gene names	HTRA3, PRSP
Domain Architecture
Description	Probable serine protease HTRA3 precursor (EC 3.4.21.-) (High- temperature requirement factor A3) (Pregnancy-related serine protease).

HTRA3_MOUSE
θ value	3.0926 (rank : 27)	NC score	0.039493 (rank : 25)
Query Neighborhood Hits	45	Target Neighborhood Hits	156	Shared Neighborhood Hits	7
SwissProt Accessions	Q9D236, Q6WLC5, Q6YDR0	Gene names	Htra3, Prsp, Tasp
Domain Architecture
Description	Probable serine protease HTRA3 precursor (EC 3.4.21.-) (High- temperature requirement factor A3) (Pregnancy-related serine protease) (Toll-associated serine protease).

PCSK5_MOUSE
θ value	3.0926 (rank : 28)	NC score	0.024226 (rank : 32)
Query Neighborhood Hits	45	Target Neighborhood Hits	613	Shared Neighborhood Hits	13
SwissProt Accessions	Q04592, Q62040	Gene names	Pcsk5
Domain Architecture
Description	Proprotein convertase subtilisin/kexin type 5 precursor (EC 3.4.21.-) (Proprotein convertase PC5) (Subtilisin/kexin-like protease PC5) (PC6) (Subtilisin-like proprotein convertase 6) (SPC6).

TNR26_MOUSE
θ value	3.0926 (rank : 29)	NC score	0.032327 (rank : 28)
Query Neighborhood Hits	45	Target Neighborhood Hits	106	Shared Neighborhood Hits	7
SwissProt Accessions	P83626	Gene names	Tnfrsf26, Tnfrh3
Domain Architecture
Description	Tumor necrosis factor receptor superfamily member 26 precursor (TNF receptor homolog 3).

FRAS1_HUMAN
θ value	4.03905 (rank : 30)	NC score	0.021359 (rank : 34)
Query Neighborhood Hits	45	Target Neighborhood Hits	759	Shared Neighborhood Hits	13
SwissProt Accessions	Q86XX4, Q86UZ4, Q8N3U9, Q8NAU7, Q96JW7, Q9H6N9, Q9P228	Gene names	FRAS1, KIAA1500
Domain Architecture	No domain graphic available
Description	Extracellular matrix protein FRAS1 precursor.

NFAC1_HUMAN
θ value	4.03905 (rank : 31)	NC score	0.023544 (rank : 33)
Query Neighborhood Hits	45	Target Neighborhood Hits	312	Shared Neighborhood Hits	8
SwissProt Accessions	O95644, Q12865, Q15793	Gene names	NFATC1, NFAT2, NFATC
Domain Architecture
Description	Nuclear factor of activated T-cells, cytoplasmic 1 (NFAT transcription complex cytosolic component) (NF-ATc1) (NF-ATc).

CORIN_MOUSE
θ value	5.27518 (rank : 32)	NC score	0.019010 (rank : 38)
Query Neighborhood Hits	45	Target Neighborhood Hits	451	Shared Neighborhood Hits	14
SwissProt Accessions	Q9Z319	Gene names	Corin, Crn, Lrp4
Domain Architecture
Description	Atrial natriuteric peptide-converting enzyme (EC 3.4.21.-) (pro-ANP- converting enzyme) (Corin) (Low density lipoprotein receptor-related protein 4).

LRP6_HUMAN
θ value	5.27518 (rank : 33)	NC score	0.058414 (rank : 15)
Query Neighborhood Hits	45	Target Neighborhood Hits	235	Shared Neighborhood Hits	13
SwissProt Accessions	O75581	Gene names	LRP6
Domain Architecture
Description	Low-density lipoprotein receptor-related protein 6 precursor.

LRP6_MOUSE
θ value	5.27518 (rank : 34)	NC score	0.057960 (rank : 16)
Query Neighborhood Hits	45	Target Neighborhood Hits	232	Shared Neighborhood Hits	12
SwissProt Accessions	O88572	Gene names	Lrp6
Domain Architecture
Description	Low-density lipoprotein receptor-related protein 6 precursor.

HMCN1_HUMAN
θ value	6.88961 (rank : 35)	NC score	0.010625 (rank : 45)
Query Neighborhood Hits	45	Target Neighborhood Hits	983	Shared Neighborhood Hits	13
SwissProt Accessions	Q96RW7, Q5TYR7, Q96DN3, Q96DN8, Q96SC3	Gene names	HMCN1, FIBL6
Domain Architecture	No domain graphic available
Description	Hemicentin-1 precursor (Fibulin-6) (FIBL-6).

IBP3_HUMAN
θ value	6.88961 (rank : 36)	NC score	0.019455 (rank : 36)
Query Neighborhood Hits	45	Target Neighborhood Hits	67	Shared Neighborhood Hits	4
SwissProt Accessions	P17936, Q2V509, Q6P1M6	Gene names	IGFBP3, IBP3
Domain Architecture
Description	Insulin-like growth factor-binding protein 3 precursor (IGFBP-3) (IBP- 3) (IGF-binding protein 3).

PRPC_HUMAN
θ value	6.88961 (rank : 37)	NC score	0.038656 (rank : 26)
Query Neighborhood Hits	45	Target Neighborhood Hits	165	Shared Neighborhood Hits	5
SwissProt Accessions	P02810, Q4VBP2, Q53XA2, Q6P2F6	Gene names	PRH1
Domain Architecture	No domain graphic available
Description	Salivary acidic proline-rich phosphoprotein 1/2 precursor (PRP-1/PRP- 2) (Parotid proline-rich protein 1/2) (Pr1/Pr2) (Protein C) (Parotid acidic protein) (Pa) (Parotid isoelectric focusing variant protein) (PIF-S) (Parotid double-band protein) (Db-s) [Contains: Salivary acidic proline-rich phosphoprotein 1/2; Salivary acidic proline-rich phosphoprotein 3/4 (PRP-3/PRP-4) (Protein A) (PIF-F) (Db-F); Peptide P-C].

SHAN1_HUMAN
θ value	6.88961 (rank : 38)	NC score	0.015243 (rank : 40)
Query Neighborhood Hits	45	Target Neighborhood Hits	1041	Shared Neighborhood Hits	14
SwissProt Accessions	Q9Y566, Q9NYW9	Gene names	SHANK1
Domain Architecture
Description	SH3 and multiple ankyrin repeat domains protein 1 (Shank1) (Somatostatin receptor-interacting protein) (SSTR-interacting protein) (SSTRIP).

CAPON_MOUSE
θ value	8.99809 (rank : 39)	NC score	0.019420 (rank : 37)
Query Neighborhood Hits	45	Target Neighborhood Hits	34	Shared Neighborhood Hits	2
SwissProt Accessions	Q9D3A8, Q80TZ6	Gene names	Nos1ap, Capon, Kiaa0464
Domain Architecture	No domain graphic available
Description	Carboxyl-terminal PDZ ligand of neuronal nitric oxide synthase protein (C--terminal PDZ ligand of neuronal nitric oxide synthase protein) (Nitric oxide synthase 1 adaptor protein).

CT112_MOUSE
θ value	8.99809 (rank : 40)	NC score	0.016745 (rank : 39)
Query Neighborhood Hits	45	Target Neighborhood Hits	35	Shared Neighborhood Hits	2
SwissProt Accessions	Q6DIB4	Gene names
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C20orf112 homolog.

GRN_HUMAN
θ value	8.99809 (rank : 41)	NC score	0.026793 (rank : 31)
Query Neighborhood Hits	45	Target Neighborhood Hits	268	Shared Neighborhood Hits	13
SwissProt Accessions	P28799, P23781, P23782, P23783, P23784, Q9BWE7, Q9UCH0	Gene names	GRN
Domain Architecture
Description	Granulins precursor (Proepithelin) (PEPI) [Contains: Acrogranin; Paragranulin; Granulin-1 (Granulin G); Granulin-2 (Granulin F); Granulin-3 (Granulin B); Granulin-4 (Granulin A); Granulin-5 (Granulin C); Granulin-6 (Granulin D); Granulin-7 (Granulin E)].

IRF5_MOUSE
θ value	8.99809 (rank : 42)	NC score	0.011140 (rank : 44)
Query Neighborhood Hits	45	Target Neighborhood Hits	49	Shared Neighborhood Hits	2
SwissProt Accessions	P56477	Gene names	Irf5
Domain Architecture
Description	Interferon regulatory factor 5 (IRF-5).

ORAI3_MOUSE
θ value	8.99809 (rank : 43)	NC score	0.015062 (rank : 41)
Query Neighborhood Hits	45	Target Neighborhood Hits	26	Shared Neighborhood Hits	3
SwissProt Accessions	Q6P8G8	Gene names	Tmem142c, Orai3
Domain Architecture	No domain graphic available
Description	Protein orai-3 (Transmembrane protein 142C).

SFPQ_HUMAN
θ value	8.99809 (rank : 44)	NC score	0.019803 (rank : 35)
Query Neighborhood Hits	45	Target Neighborhood Hits	986	Shared Neighborhood Hits	11
SwissProt Accessions	P23246, P30808	Gene names	SFPQ, PSF
Domain Architecture
Description	Splicing factor, proline- and glutamine-rich (Polypyrimidine tract- binding protein-associated-splicing factor) (PTB-associated-splicing factor) (PSF) (DNA-binding p52/p100 complex, 100 kDa subunit) (100 kDa DNA-pairing protein) (hPOMp100).

TRI42_MOUSE
θ value	8.99809 (rank : 45)	NC score	0.013296 (rank : 42)
Query Neighborhood Hits	45	Target Neighborhood Hits	316	Shared Neighborhood Hits	6
SwissProt Accessions	Q9D2H5	Gene names	Trim42
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 42.

OGFR_MOUSE
θ value	θ > 10 (rank : 46)	NC score	0.053143 (rank : 18)
Query Neighborhood Hits	45	Target Neighborhood Hits	584	Shared Neighborhood Hits	13
SwissProt Accessions	Q99PG2, Q99L33	Gene names	Ogfr
Domain Architecture
Description	Opioid growth factor receptor (OGFr) (Zeta-type opioid receptor).

Hits sorted by NC score

MDFI_HUMAN
NC score	0.999962 (rank : 1)	θ value	1.64657e-102 (rank : 1)
Query Neighborhood Hits	45	Target Neighborhood Hits	45	Shared Neighborhood Hits	45
SwissProt Accessions	Q99750	Gene names	MDFI
Domain Architecture	No domain graphic available
Description	MyoD family inhibitor (Myogenic repressor I-mf).

MDFI_MOUSE
NC score	0.901438 (rank : 2)	θ value	7.51208e-47 (rank : 2)
Query Neighborhood Hits	45	Target Neighborhood Hits	20	Shared Neighborhood Hits	3
SwissProt Accessions	P70331, P70330, P70332, Q99JM9	Gene names	Mdfi
Domain Architecture	No domain graphic available
Description	MyoD family inhibitor (Myogenic repressor I-mf).

PIGQ_HUMAN
NC score	0.074821 (rank : 3)	θ value	0.365318 (rank : 6)
Query Neighborhood Hits	45	Target Neighborhood Hits	84	Shared Neighborhood Hits	3
SwissProt Accessions	Q9BRB3, O14927, Q96G00, Q96S22, Q9UJH4	Gene names	PIGQ, GPI1
Domain Architecture
Description	Phosphatidylinositol N-acetylglucosaminyltransferase subunit Q (EC 2.4.1.198) (Phosphatidylinositol-glycan biosynthesis class Q protein) (PIG-Q) (N-acetylglucosamyl transferase component GPI1).

CO5A1_HUMAN
NC score	0.072849 (rank : 4)	θ value	1.06291 (rank : 11)
Query Neighborhood Hits	45	Target Neighborhood Hits	434	Shared Neighborhood Hits	10
SwissProt Accessions	P20908, Q15094, Q5SUX4	Gene names	COL5A1
Domain Architecture
Description	Collagen alpha-1(V) chain precursor.

CO5A1_MOUSE
NC score	0.070899 (rank : 5)	θ value	1.81305 (rank : 18)
Query Neighborhood Hits	45	Target Neighborhood Hits	419	Shared Neighborhood Hits	10
SwissProt Accessions	O88207	Gene names	Col5a1
Domain Architecture	No domain graphic available
Description	Collagen alpha-1(V) chain precursor.

COBA2_HUMAN
NC score	0.068641 (rank : 6)	θ value	0.47712 (rank : 7)
Query Neighborhood Hits	45	Target Neighborhood Hits	408	Shared Neighborhood Hits	9
SwissProt Accessions	P13942, Q07751, Q13271, Q13272, Q13273, Q99866, Q9UIP9	Gene names	COL11A2
Domain Architecture
Description	Collagen alpha-2(XI) chain precursor.

PRG4_HUMAN
NC score	0.068116 (rank : 7)	θ value	0.0961366 (rank : 3)
Query Neighborhood Hits	45	Target Neighborhood Hits	764	Shared Neighborhood Hits	9
SwissProt Accessions	Q92954, Q6DNC4, Q6DNC5, Q6ZMZ5, Q9BX49	Gene names	PRG4, MSF, SZP
Domain Architecture	No domain graphic available
Description	Proteoglycan-4 precursor (Lubricin) (Megakaryocyte-stimulating factor) (Superficial zone proteoglycan) [Contains: Proteoglycan-4 C-terminal part].

COBA2_MOUSE
NC score	0.066673 (rank : 8)	θ value	0.813845 (rank : 9)
Query Neighborhood Hits	45	Target Neighborhood Hits	501	Shared Neighborhood Hits	12
SwissProt Accessions	Q64739, Q61432, Q9Z1W0	Gene names	Col11a2
Domain Architecture
Description	Collagen alpha-2(XI) chain precursor.

OGFR_HUMAN
NC score	0.066479 (rank : 9)	θ value	0.163984 (rank : 5)
Query Neighborhood Hits	45	Target Neighborhood Hits	1582	Shared Neighborhood Hits	21
SwissProt Accessions	Q9NZT2, O96029, Q4VXW5, Q96CM2, Q9BQW1, Q9H4H0, Q9H7J5, Q9NZT3, Q9NZT4	Gene names	OGFR
Domain Architecture
Description	Opioid growth factor receptor (OGFr) (Zeta-type opioid receptor) (7-60 protein).

LRP5_HUMAN
NC score	0.064547 (rank : 10)	θ value	0.47712 (rank : 8)
Query Neighborhood Hits	45	Target Neighborhood Hits	224	Shared Neighborhood Hits	11
SwissProt Accessions	O75197, Q96TD6, Q9UP66	Gene names	LRP5, LRP7
Domain Architecture
Description	Low-density lipoprotein receptor-related protein 5 precursor.

COBA1_HUMAN
NC score	0.064315 (rank : 11)	θ value	1.81305 (rank : 21)
Query Neighborhood Hits	45	Target Neighborhood Hits	491	Shared Neighborhood Hits	12
SwissProt Accessions	P12107, Q14034, Q9UIT4, Q9UIT5, Q9UIT6	Gene names	COL11A1
Domain Architecture
Description	Collagen alpha-1(XI) chain precursor.

COBA1_MOUSE
NC score	0.064145 (rank : 12)	θ value	1.38821 (rank : 14)
Query Neighborhood Hits	45	Target Neighborhood Hits	487	Shared Neighborhood Hits	11
SwissProt Accessions	Q61245, Q64047	Gene names	Col11a1
Domain Architecture
Description	Collagen alpha-1(XI) chain precursor.

LRP5_MOUSE
NC score	0.061736 (rank : 13)	θ value	1.81305 (rank : 22)
Query Neighborhood Hits	45	Target Neighborhood Hits	236	Shared Neighborhood Hits	11
SwissProt Accessions	Q91VN0, O88883, Q9R208	Gene names	Lrp5, Lrp7
Domain Architecture
Description	Low-density lipoprotein receptor-related protein 5 precursor (LRP7) (Lr3).

PRG4_MOUSE
NC score	0.061186 (rank : 14)	θ value	1.38821 (rank : 16)
Query Neighborhood Hits	45	Target Neighborhood Hits	624	Shared Neighborhood Hits	8
SwissProt Accessions	Q9JM99, Q3UEL1, Q3V198	Gene names	Prg4, Msf, Szp
Domain Architecture	No domain graphic available
Description	Proteoglycan-4 precursor (Lubricin) (Megakaryocyte-stimulating factor) (Superficial zone proteoglycan) [Contains: Proteoglycan-4 C-terminal part].

LRP6_HUMAN
NC score	0.058414 (rank : 15)	θ value	5.27518 (rank : 33)
Query Neighborhood Hits	45	Target Neighborhood Hits	235	Shared Neighborhood Hits	13
SwissProt Accessions	O75581	Gene names	LRP6
Domain Architecture
Description	Low-density lipoprotein receptor-related protein 6 precursor.

LRP6_MOUSE
NC score	0.057960 (rank : 16)	θ value	5.27518 (rank : 34)
Query Neighborhood Hits	45	Target Neighborhood Hits	232	Shared Neighborhood Hits	12
SwissProt Accessions	O88572	Gene names	Lrp6
Domain Architecture
Description	Low-density lipoprotein receptor-related protein 6 precursor.

CO8B_HUMAN
NC score	0.054059 (rank : 17)	θ value	1.81305 (rank : 19)
Query Neighborhood Hits	45	Target Neighborhood Hits	199	Shared Neighborhood Hits	10
SwissProt Accessions	P07358	Gene names	C8B
Domain Architecture
Description	Complement component C8 beta chain precursor (Complement component 8 subunit beta).

OGFR_MOUSE
NC score	0.053143 (rank : 18)	θ value	θ > 10 (rank : 46)
Query Neighborhood Hits	45	Target Neighborhood Hits	584	Shared Neighborhood Hits	13
SwissProt Accessions	Q99PG2, Q99L33	Gene names	Ogfr
Domain Architecture
Description	Opioid growth factor receptor (OGFr) (Zeta-type opioid receptor).

MLL3_MOUSE
NC score	0.052484 (rank : 19)	θ value	0.125558 (rank : 4)
Query Neighborhood Hits	45	Target Neighborhood Hits	1399	Shared Neighborhood Hits	18
SwissProt Accessions	Q8BRH4, Q5YLV9, Q8BK12, Q8C6M3, Q923H5, Q923H6	Gene names	Mll3
Domain Architecture
Description	Myeloid/lymphoid or mixed-lineage leukemia protein 3 homolog (EC 2.1.1.43) (Histone-lysine N-methyltransferase, H3 lysine-4 specific MLL3).

CO8B_MOUSE
NC score	0.051480 (rank : 20)	θ value	1.81305 (rank : 20)
Query Neighborhood Hits	45	Target Neighborhood Hits	224	Shared Neighborhood Hits	10
SwissProt Accessions	Q8BH35, Q4VAH1, Q8CHJ5, Q8CHJ6, Q8VC14	Gene names	C8b
Domain Architecture	No domain graphic available
Description	Complement component C8 beta chain precursor (Complement component 8 subunit beta).

CK024_HUMAN
NC score	0.049782 (rank : 21)	θ value	2.36792 (rank : 25)
Query Neighborhood Hits	45	Target Neighborhood Hits	408	Shared Neighborhood Hits	9
SwissProt Accessions	Q96F05, Q9H2K4	Gene names	C11orf24
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C11orf24 precursor (Protein DM4E3).

LRP2_HUMAN
NC score	0.048579 (rank : 22)	θ value	1.38821 (rank : 15)
Query Neighborhood Hits	45	Target Neighborhood Hits	573	Shared Neighborhood Hits	16
SwissProt Accessions	P98164, O00711, Q16215	Gene names	LRP2
Domain Architecture
Description	Low-density lipoprotein receptor-related protein 2 precursor (Megalin) (Glycoprotein 330) (gp330).

UBXD2_MOUSE
NC score	0.044482 (rank : 23)	θ value	1.81305 (rank : 23)
Query Neighborhood Hits	45	Target Neighborhood Hits	183	Shared Neighborhood Hits	2
SwissProt Accessions	Q8VCH8, Q8BW17	Gene names	Ubxd2, Ubxdc1
Domain Architecture
Description	UBX domain-containing protein 2.

HTRA3_HUMAN
NC score	0.040484 (rank : 24)	θ value	2.36792 (rank : 26)
Query Neighborhood Hits	45	Target Neighborhood Hits	152	Shared Neighborhood Hits	5
SwissProt Accessions	P83110, Q7Z7A2	Gene names	HTRA3, PRSP
Domain Architecture
Description	Probable serine protease HTRA3 precursor (EC 3.4.21.-) (High- temperature requirement factor A3) (Pregnancy-related serine protease).

HTRA3_MOUSE
NC score	0.039493 (rank : 25)	θ value	3.0926 (rank : 27)
Query Neighborhood Hits	45	Target Neighborhood Hits	156	Shared Neighborhood Hits	7
SwissProt Accessions	Q9D236, Q6WLC5, Q6YDR0	Gene names	Htra3, Prsp, Tasp
Domain Architecture
Description	Probable serine protease HTRA3 precursor (EC 3.4.21.-) (High- temperature requirement factor A3) (Pregnancy-related serine protease) (Toll-associated serine protease).

PRPC_HUMAN
NC score	0.038656 (rank : 26)	θ value	6.88961 (rank : 37)
Query Neighborhood Hits	45	Target Neighborhood Hits	165	Shared Neighborhood Hits	5
SwissProt Accessions	P02810, Q4VBP2, Q53XA2, Q6P2F6	Gene names	PRH1
Domain Architecture	No domain graphic available
Description	Salivary acidic proline-rich phosphoprotein 1/2 precursor (PRP-1/PRP- 2) (Parotid proline-rich protein 1/2) (Pr1/Pr2) (Protein C) (Parotid acidic protein) (Pa) (Parotid isoelectric focusing variant protein) (PIF-S) (Parotid double-band protein) (Db-s) [Contains: Salivary acidic proline-rich phosphoprotein 1/2; Salivary acidic proline-rich phosphoprotein 3/4 (PRP-3/PRP-4) (Protein A) (PIF-F) (Db-F); Peptide P-C].

RGS3_HUMAN
NC score	0.036754 (rank : 27)	θ value	1.06291 (rank : 13)
Query Neighborhood Hits	45	Target Neighborhood Hits	1375	Shared Neighborhood Hits	17
SwissProt Accessions	P49796, Q5VXC1, Q5VZ05, Q6ZRM5, Q8IUQ1, Q8NC47, Q8NFN4, Q8NFN5, Q8TD59, Q8TD68, Q8WXA0	Gene names	RGS3
Domain Architecture
Description	Regulator of G-protein signaling 3 (RGS3) (RGP3).

TNR26_MOUSE
NC score	0.032327 (rank : 28)	θ value	3.0926 (rank : 29)
Query Neighborhood Hits	45	Target Neighborhood Hits	106	Shared Neighborhood Hits	7
SwissProt Accessions	P83626	Gene names	Tnfrsf26, Tnfrh3
Domain Architecture
Description	Tumor necrosis factor receptor superfamily member 26 precursor (TNF receptor homolog 3).

CSPG2_MOUSE
NC score	0.027907 (rank : 29)	θ value	0.813845 (rank : 10)
Query Neighborhood Hits	45	Target Neighborhood Hits	711	Shared Neighborhood Hits	9
SwissProt Accessions	Q62059, Q62058, Q9CUU0	Gene names	Cspg2
Domain Architecture
Description	Versican core protein precursor (Large fibroblast proteoglycan) (Chondroitin sulfate proteoglycan core protein 2) (PG-M).

NECD_HUMAN
NC score	0.027153 (rank : 30)	θ value	1.06291 (rank : 12)
Query Neighborhood Hits	45	Target Neighborhood Hits	82	Shared Neighborhood Hits	3
SwissProt Accessions	Q99608	Gene names	NDN
Domain Architecture
Description	Necdin.

GRN_HUMAN
NC score	0.026793 (rank : 31)	θ value	8.99809 (rank : 41)
Query Neighborhood Hits	45	Target Neighborhood Hits	268	Shared Neighborhood Hits	13
SwissProt Accessions	P28799, P23781, P23782, P23783, P23784, Q9BWE7, Q9UCH0	Gene names	GRN
Domain Architecture
Description	Granulins precursor (Proepithelin) (PEPI) [Contains: Acrogranin; Paragranulin; Granulin-1 (Granulin G); Granulin-2 (Granulin F); Granulin-3 (Granulin B); Granulin-4 (Granulin A); Granulin-5 (Granulin C); Granulin-6 (Granulin D); Granulin-7 (Granulin E)].

PCSK5_MOUSE
NC score	0.024226 (rank : 32)	θ value	3.0926 (rank : 28)
Query Neighborhood Hits	45	Target Neighborhood Hits	613	Shared Neighborhood Hits	13
SwissProt Accessions	Q04592, Q62040	Gene names	Pcsk5
Domain Architecture
Description	Proprotein convertase subtilisin/kexin type 5 precursor (EC 3.4.21.-) (Proprotein convertase PC5) (Subtilisin/kexin-like protease PC5) (PC6) (Subtilisin-like proprotein convertase 6) (SPC6).

NFAC1_HUMAN
NC score	0.023544 (rank : 33)	θ value	4.03905 (rank : 31)
Query Neighborhood Hits	45	Target Neighborhood Hits	312	Shared Neighborhood Hits	8
SwissProt Accessions	O95644, Q12865, Q15793	Gene names	NFATC1, NFAT2, NFATC
Domain Architecture
Description	Nuclear factor of activated T-cells, cytoplasmic 1 (NFAT transcription complex cytosolic component) (NF-ATc1) (NF-ATc).

FRAS1_HUMAN
NC score	0.021359 (rank : 34)	θ value	4.03905 (rank : 30)
Query Neighborhood Hits	45	Target Neighborhood Hits	759	Shared Neighborhood Hits	13
SwissProt Accessions	Q86XX4, Q86UZ4, Q8N3U9, Q8NAU7, Q96JW7, Q9H6N9, Q9P228	Gene names	FRAS1, KIAA1500
Domain Architecture	No domain graphic available
Description	Extracellular matrix protein FRAS1 precursor.

SFPQ_HUMAN
NC score	0.019803 (rank : 35)	θ value	8.99809 (rank : 44)
Query Neighborhood Hits	45	Target Neighborhood Hits	986	Shared Neighborhood Hits	11
SwissProt Accessions	P23246, P30808	Gene names	SFPQ, PSF
Domain Architecture
Description	Splicing factor, proline- and glutamine-rich (Polypyrimidine tract- binding protein-associated-splicing factor) (PTB-associated-splicing factor) (PSF) (DNA-binding p52/p100 complex, 100 kDa subunit) (100 kDa DNA-pairing protein) (hPOMp100).

IBP3_HUMAN
NC score	0.019455 (rank : 36)	θ value	6.88961 (rank : 36)
Query Neighborhood Hits	45	Target Neighborhood Hits	67	Shared Neighborhood Hits	4
SwissProt Accessions	P17936, Q2V509, Q6P1M6	Gene names	IGFBP3, IBP3
Domain Architecture
Description	Insulin-like growth factor-binding protein 3 precursor (IGFBP-3) (IBP- 3) (IGF-binding protein 3).

CAPON_MOUSE
NC score	0.019420 (rank : 37)	θ value	8.99809 (rank : 39)
Query Neighborhood Hits	45	Target Neighborhood Hits	34	Shared Neighborhood Hits	2
SwissProt Accessions	Q9D3A8, Q80TZ6	Gene names	Nos1ap, Capon, Kiaa0464
Domain Architecture	No domain graphic available
Description	Carboxyl-terminal PDZ ligand of neuronal nitric oxide synthase protein (C--terminal PDZ ligand of neuronal nitric oxide synthase protein) (Nitric oxide synthase 1 adaptor protein).

CORIN_MOUSE
NC score	0.019010 (rank : 38)	θ value	5.27518 (rank : 32)
Query Neighborhood Hits	45	Target Neighborhood Hits	451	Shared Neighborhood Hits	14
SwissProt Accessions	Q9Z319	Gene names	Corin, Crn, Lrp4
Domain Architecture
Description	Atrial natriuteric peptide-converting enzyme (EC 3.4.21.-) (pro-ANP- converting enzyme) (Corin) (Low density lipoprotein receptor-related protein 4).

CT112_MOUSE
NC score	0.016745 (rank : 39)	θ value	8.99809 (rank : 40)
Query Neighborhood Hits	45	Target Neighborhood Hits	35	Shared Neighborhood Hits	2
SwissProt Accessions	Q6DIB4	Gene names
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C20orf112 homolog.

SHAN1_HUMAN
NC score	0.015243 (rank : 40)	θ value	6.88961 (rank : 38)
Query Neighborhood Hits	45	Target Neighborhood Hits	1041	Shared Neighborhood Hits	14
SwissProt Accessions	Q9Y566, Q9NYW9	Gene names	SHANK1
Domain Architecture
Description	SH3 and multiple ankyrin repeat domains protein 1 (Shank1) (Somatostatin receptor-interacting protein) (SSTR-interacting protein) (SSTRIP).

ORAI3_MOUSE
NC score	0.015062 (rank : 41)	θ value	8.99809 (rank : 43)
Query Neighborhood Hits	45	Target Neighborhood Hits	26	Shared Neighborhood Hits	3
SwissProt Accessions	Q6P8G8	Gene names	Tmem142c, Orai3
Domain Architecture	No domain graphic available
Description	Protein orai-3 (Transmembrane protein 142C).

TRI42_MOUSE
NC score	0.013296 (rank : 42)	θ value	8.99809 (rank : 45)
Query Neighborhood Hits	45	Target Neighborhood Hits	316	Shared Neighborhood Hits	6
SwissProt Accessions	Q9D2H5	Gene names	Trim42
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 42.

WNK2_HUMAN
NC score	0.012220 (rank : 43)	θ value	1.81305 (rank : 24)
Query Neighborhood Hits	45	Target Neighborhood Hits	1407	Shared Neighborhood Hits	11
SwissProt Accessions	Q9Y3S1, Q8IY36, Q9C0A3, Q9H3P4	Gene names	WNK2, KIAA1760, PRKWNK2
Domain Architecture
Description	Serine/threonine-protein kinase WNK2 (EC 2.7.11.1) (Protein kinase with no lysine 2) (Protein kinase, lysine-deficient 2).

IRF5_MOUSE
NC score	0.011140 (rank : 44)	θ value	8.99809 (rank : 42)
Query Neighborhood Hits	45	Target Neighborhood Hits	49	Shared Neighborhood Hits	2
SwissProt Accessions	P56477	Gene names	Irf5
Domain Architecture
Description	Interferon regulatory factor 5 (IRF-5).

HMCN1_HUMAN
NC score	0.010625 (rank : 45)	θ value	6.88961 (rank : 35)
Query Neighborhood Hits	45	Target Neighborhood Hits	983	Shared Neighborhood Hits	13
SwissProt Accessions	Q96RW7, Q5TYR7, Q96DN3, Q96DN8, Q96SC3	Gene names	HMCN1, FIBL6
Domain Architecture	No domain graphic available
Description	Hemicentin-1 precursor (Fibulin-6) (FIBL-6).

BRSK1_HUMAN
NC score	0.006733 (rank : 46)	θ value	1.81305 (rank : 17)
Query Neighborhood Hits	45	Target Neighborhood Hits	942	Shared Neighborhood Hits	6
SwissProt Accessions	Q8TDC3, Q5J5B5, Q8NDD0, Q8NDR4, Q8TDC2, Q96AV4, Q96JL4	Gene names	BRSK1, KIAA1811, SAD1
Domain Architecture
Description	BR serine/threonine-protein kinase 1 (EC 2.7.11.1) (SAD1 kinase) (SAD1A).