Please be patient as the page loads

Stop Image Loading/Displaying

Network neighborhood for query Sequence : SPIT1_MOUSE

For an explanation of this page, click here

SPIT1_MOUSE
SwissProt Accessions	Q9R097	Gene names	Spint1, Hai1
Domain Architecture
Description	Kunitz-type protease inhibitor 1 precursor (Hepatocyte growth factor activator inhibitor type 1) (HAI-1).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

SPIT1_HUMAN
θ value	0 (rank : 1)	NC score	0.987749 (rank : 2)
Query Neighborhood Hits	96	Target Neighborhood Hits	100	Shared Neighborhood Hits	81
SwissProt Accessions	O43278, Q7Z7D2	Gene names	SPINT1, HAI1
Domain Architecture
Description	Kunitz-type protease inhibitor 1 precursor (Hepatocyte growth factor activator inhibitor type 1) (HAI-1).

SPIT1_MOUSE
θ value	0 (rank : 2)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	96	Target Neighborhood Hits	96	Shared Neighborhood Hits	96
SwissProt Accessions	Q9R097	Gene names	Spint1, Hai1
Domain Architecture
Description	Kunitz-type protease inhibitor 1 precursor (Hepatocyte growth factor activator inhibitor type 1) (HAI-1).

SPIT2_HUMAN
θ value	4.73814e-25 (rank : 3)	NC score	0.740255 (rank : 3)
Query Neighborhood Hits	96	Target Neighborhood Hits	21	Shared Neighborhood Hits	20
SwissProt Accessions	O43291, O00271, O14895, Q5TZQ3, Q969E0	Gene names	SPINT2, HAI2, KOP
Domain Architecture
Description	Kunitz-type protease inhibitor 2 precursor (Hepatocyte growth factor activator inhibitor type 2) (HAI-2) (Placental bikunin).

LRP11_MOUSE
θ value	2.35151e-24 (rank : 4)	NC score	0.594815 (rank : 10)
Query Neighborhood Hits	96	Target Neighborhood Hits	81	Shared Neighborhood Hits	63
SwissProt Accessions	Q8CB67, Q8C7Y7	Gene names	Lrp11
Domain Architecture
Description	Low-density lipoprotein receptor-related protein 11 precursor.

LRP11_HUMAN
θ value	3.75424e-22 (rank : 5)	NC score	0.589525 (rank : 11)
Query Neighborhood Hits	96	Target Neighborhood Hits	82	Shared Neighborhood Hits	58
SwissProt Accessions	Q86VZ4, Q5VYC0, Q96SN6	Gene names	LRP11
Domain Architecture
Description	Low-density lipoprotein receptor-related protein 11 precursor.

SPIT2_MOUSE
θ value	4.9032e-22 (rank : 6)	NC score	0.715525 (rank : 6)
Query Neighborhood Hits	96	Target Neighborhood Hits	24	Shared Neighborhood Hits	21
SwissProt Accessions	Q9WU03, Q9WU04, Q9WU05	Gene names	Spint2, Hai2
Domain Architecture
Description	Kunitz-type protease inhibitor 2 precursor (Hepatocyte growth factor activator inhibitor type 2) (HAI-2).

TFPI2_HUMAN
θ value	2.69047e-20 (rank : 7)	NC score	0.722076 (rank : 4)
Query Neighborhood Hits	96	Target Neighborhood Hits	24	Shared Neighborhood Hits	20
SwissProt Accessions	P48307	Gene names	TFPI2
Domain Architecture
Description	Tissue factor pathway inhibitor 2 precursor (TFPI-2) (Placental protein 5) (PP5).

TFPI1_HUMAN
θ value	3.51386e-20 (rank : 8)	NC score	0.706271 (rank : 7)
Query Neighborhood Hits	96	Target Neighborhood Hits	20	Shared Neighborhood Hits	20
SwissProt Accessions	P10646, O95103	Gene names	TFPI, LACI, TFPI1
Domain Architecture
Description	Tissue factor pathway inhibitor precursor (TFPI) (Lipoprotein- associated coagulation inhibitor) (LACI) (Extrinsic pathway inhibitor) (EPI).

TFPI2_MOUSE
θ value	7.82807e-20 (rank : 9)	NC score	0.719728 (rank : 5)
Query Neighborhood Hits	96	Target Neighborhood Hits	23	Shared Neighborhood Hits	20
SwissProt Accessions	O35536	Gene names	Tfpi2
Domain Architecture
Description	Tissue factor pathway inhibitor 2 precursor (TFPI-2).

TFPI1_MOUSE
θ value	1.74391e-19 (rank : 10)	NC score	0.701843 (rank : 8)
Query Neighborhood Hits	96	Target Neighborhood Hits	22	Shared Neighborhood Hits	20
SwissProt Accessions	O54819, Q9Z2U8	Gene names	Tfpi
Domain Architecture
Description	Tissue factor pathway inhibitor precursor (TFPI) (Lipoprotein- associated coagulation inhibitor) (LACI) (Extrinsic pathway inhibitor) (EPI).

AMBP_MOUSE
θ value	1.33837e-11 (rank : 11)	NC score	0.535442 (rank : 15)
Query Neighborhood Hits	96	Target Neighborhood Hits	48	Shared Neighborhood Hits	20
SwissProt Accessions	Q07456, Q61294	Gene names	Ambp, Itil
Domain Architecture
Description	AMBP protein precursor [Contains: Alpha-1-microglobulin; Inter-alpha- trypsin inhibitor light chain (ITI-LC) (Bikunin) (HI-30)].

AMBP_HUMAN
θ value	5.08577e-11 (rank : 12)	NC score	0.544641 (rank : 14)
Query Neighborhood Hits	96	Target Neighborhood Hits	46	Shared Neighborhood Hits	20
SwissProt Accessions	P02760, P00977, P02759	Gene names	AMBP, HCP, ITIL
Domain Architecture
Description	AMBP protein precursor [Contains: Alpha-1-microglobulin (Protein HC) (Complex-forming glycoprotein heterogeneous in charge) (Alpha-1 microglycoprotein); Inter-alpha-trypsin inhibitor light chain (ITI-LC) (Bikunin) (HI-30)].

APLP2_HUMAN
θ value	1.47974e-10 (rank : 13)	NC score	0.422605 (rank : 19)
Query Neighborhood Hits	96	Target Neighborhood Hits	193	Shared Neighborhood Hits	20
SwissProt Accessions	Q06481	Gene names	APLP2, APPL2
Domain Architecture
Description	Amyloid-like protein 2 precursor (Amyloid protein homolog) (APPH) (CDEI box-binding protein) (CDEBP).

A4_HUMAN
θ value	3.29651e-10 (rank : 14)	NC score	0.423960 (rank : 18)
Query Neighborhood Hits	96	Target Neighborhood Hits	274	Shared Neighborhood Hits	20
SwissProt Accessions	P05067, P09000, P78438, Q13764, Q13778, Q13793, Q16011, Q16014, Q16019, Q16020, Q9BT38, Q9UCA9, Q9UCB6, Q9UCC8, Q9UCD1, Q9UQ58	Gene names	APP, A4, AD1
Domain Architecture	No domain graphic available
Description	Amyloid beta A4 protein precursor (APP) (ABPP) (Alzheimer disease amyloid protein) (Cerebral vascular amyloid peptide) (CVAP) (Protease nexin-II) (PN-II) (APPI) (PreA4) [Contains: Soluble APP-alpha (S-APP- alpha); Soluble APP-beta (S-APP-beta); C99; Beta-amyloid protein 42 (Beta-APP42); Beta-amyloid protein 40 (Beta-APP40); C83; P3(42); P3(40); Gamma-CTF(59) (Gamma-secretase C-terminal fragment 59) (Amyloid intracellular domain 59) (AID(59)); Gamma-CTF(57) (Gamma- secretase C-terminal fragment 57) (Amyloid intracellular domain 57) (AID(57)); Gamma-CTF(50) (Gamma-secretase C-terminal fragment 50) (Amyloid intracellular domain 50) (AID(50)); C31].

A4_MOUSE
θ value	3.29651e-10 (rank : 15)	NC score	0.427045 (rank : 17)
Query Neighborhood Hits	96	Target Neighborhood Hits	275	Shared Neighborhood Hits	20
SwissProt Accessions	P12023, P97487, P97942, Q99K32	Gene names	App
Domain Architecture	No domain graphic available
Description	Amyloid beta A4 protein precursor (APP) (ABPP) (Alzheimer disease amyloid protein homolog) (Amyloidogenic glycoprotein) (AG) [Contains: Soluble APP-alpha (S-APP-alpha); Soluble APP-beta (S-APP-beta); C99 (APP-C99); Beta-amyloid protein 42 (Beta-APP42); Beta-amyloid protein 40 (Beta-APP40); C83; P3(42); P3(40); Gamma-CTF(59) (Gamma-secretase C-terminal fragment 59) (Amyloid intracellular domain 59) (AID(59)) (APP-C59); Gamma-CTF(57) (Gamma-secretase C-terminal fragment 57) (Amyloid intracellular domain 57) (AID(57)) (APP-C57); Gamma-CTF(50) (Gamma-secretase C-terminal fragment 50) (Amyloid intracellular domain 50) (AID(50)); C31].

CO6A3_HUMAN
θ value	1.63604e-09 (rank : 16)	NC score	0.213041 (rank : 47)
Query Neighborhood Hits	96	Target Neighborhood Hits	317	Shared Neighborhood Hits	20
SwissProt Accessions	P12111, Q16501	Gene names	COL6A3
Domain Architecture
Description	Collagen alpha-3(VI) chain precursor.

EPPI_HUMAN
θ value	5.26297e-08 (rank : 17)	NC score	0.575912 (rank : 12)
Query Neighborhood Hits	96	Target Neighborhood Hits	33	Shared Neighborhood Hits	20
SwissProt Accessions	O95925, Q86TP9, Q96SD7, Q9HD30	Gene names	SPINLW1, WAP7, WFDC7
Domain Architecture
Description	Eppin precursor (Epididymal protease inhibitor) (Serine protease inhibitor-like with Kunitz and WAP domains 1) (WAP four-disulfide core domain protein 7) (Protease inhibitor WAP7).

WFDC8_HUMAN
θ value	8.97725e-08 (rank : 18)	NC score	0.485813 (rank : 16)
Query Neighborhood Hits	96	Target Neighborhood Hits	82	Shared Neighborhood Hits	22
SwissProt Accessions	Q8IUA0, Q5TDV2, Q96A34	Gene names	WFDC8, C20orf170, WAP8
Domain Architecture
Description	WAP four-disulfide core domain protein 8 precursor (Putative protease inhibitor WAP8).

EPPI_MOUSE
θ value	2.61198e-07 (rank : 19)	NC score	0.573727 (rank : 13)
Query Neighborhood Hits	96	Target Neighborhood Hits	43	Shared Neighborhood Hits	23
SwissProt Accessions	Q9DA01	Gene names	Spinlw1
Domain Architecture
Description	Eppin precursor (Epididymal protease inhibitor) (Serine protease inhibitor-like with Kunitz and WAP domains 1).

LRP1B_HUMAN
θ value	3.77169e-06 (rank : 20)	NC score	0.288710 (rank : 40)
Query Neighborhood Hits	96	Target Neighborhood Hits	602	Shared Neighborhood Hits	69
SwissProt Accessions	Q9NZR2, Q8WY29, Q8WY30, Q8WY31	Gene names	LRP1B, LRPDIT
Domain Architecture
Description	Low-density lipoprotein receptor-related protein 1B precursor (Low- density lipoprotein receptor-related protein-deleted in tumor) (LRP- DIT).

SORL_MOUSE
θ value	1.09739e-05 (rank : 21)	NC score	0.314225 (rank : 32)
Query Neighborhood Hits	96	Target Neighborhood Hits	439	Shared Neighborhood Hits	70
SwissProt Accessions	O88307, O54711, O70581	Gene names	Sorl1
Domain Architecture
Description	Sortilin-related receptor precursor (Sorting protein-related receptor containing LDLR class A repeats) (mSorLA) (SorLA-1) (Low-density lipoprotein receptor relative with 11 ligand-binding repeats) (LDLR relative with 11 ligand-binding repeats) (LR11) (Gp250).

LRP1B_MOUSE
θ value	3.19293e-05 (rank : 22)	NC score	0.288417 (rank : 41)
Query Neighborhood Hits	96	Target Neighborhood Hits	606	Shared Neighborhood Hits	69
SwissProt Accessions	Q9JI18, Q8BZD3, Q8BZM7	Gene names	Lrp1b, Lrpdit
Domain Architecture
Description	Low-density lipoprotein receptor-related protein 1B precursor (Low- density lipoprotein receptor-related protein-deleted in tumor) (LRP- DIT).

SPIT3_HUMAN
θ value	7.1131e-05 (rank : 23)	NC score	0.661422 (rank : 9)
Query Neighborhood Hits	96	Target Neighborhood Hits	20	Shared Neighborhood Hits	20
SwissProt Accessions	P49223, Q6UDR8, Q96KK2	Gene names	SPINT3
Domain Architecture	No domain graphic available
Description	Kunitz-type protease inhibitor 3 precursor (HKIB9).

ST14_HUMAN
θ value	9.29e-05 (rank : 24)	NC score	0.195121 (rank : 51)
Query Neighborhood Hits	96	Target Neighborhood Hits	409	Shared Neighborhood Hits	67
SwissProt Accessions	Q9Y5Y6, Q9BS01, Q9H3S0, Q9HB36, Q9HCA3	Gene names	ST14, PRSS14, SNC19, TADG15
Domain Architecture
Description	Suppressor of tumorigenicity protein 14 (EC 3.4.21.-) (Serine protease 14) (Matriptase) (Membrane-type serine protease 1) (MT-SP1) (Prostamin) (Serine protease TADG-15) (Tumor-associated differentially-expressed gene 15 protein).

LRP5_MOUSE
θ value	0.000158464 (rank : 25)	NC score	0.344339 (rank : 22)
Query Neighborhood Hits	96	Target Neighborhood Hits	236	Shared Neighborhood Hits	67
SwissProt Accessions	Q91VN0, O88883, Q9R208	Gene names	Lrp5, Lrp7
Domain Architecture
Description	Low-density lipoprotein receptor-related protein 5 precursor (LRP7) (Lr3).

VLDLR_HUMAN
θ value	0.000158464 (rank : 26)	NC score	0.316833 (rank : 30)
Query Neighborhood Hits	96	Target Neighborhood Hits	383	Shared Neighborhood Hits	69
SwissProt Accessions	P98155, Q5VVF6	Gene names	VLDLR
Domain Architecture
Description	Very low-density lipoprotein receptor precursor (VLDL receptor) (VLDL- R).

VLDLR_MOUSE
θ value	0.000158464 (rank : 27)	NC score	0.315242 (rank : 31)
Query Neighborhood Hits	96	Target Neighborhood Hits	360	Shared Neighborhood Hits	69
SwissProt Accessions	P98156, Q64022	Gene names	Vldlr
Domain Architecture
Description	Very low-density lipoprotein receptor precursor (VLDL receptor) (VLDL- R).

LDLR_HUMAN
θ value	0.00020696 (rank : 28)	NC score	0.309039 (rank : 37)
Query Neighborhood Hits	96	Target Neighborhood Hits	375	Shared Neighborhood Hits	69
SwissProt Accessions	P01130, Q53ZD9	Gene names	LDLR
Domain Architecture
Description	Low-density lipoprotein receptor precursor (LDL receptor).

SORL_HUMAN
θ value	0.00020696 (rank : 29)	NC score	0.306921 (rank : 38)
Query Neighborhood Hits	96	Target Neighborhood Hits	440	Shared Neighborhood Hits	68
SwissProt Accessions	Q92673, Q92856	Gene names	SORL1
Domain Architecture
Description	Sortilin-related receptor precursor (Sorting protein-related receptor containing LDLR class A repeats) (SorLA) (SorLA-1) (Low-density lipoprotein receptor relative with 11 ligand-binding repeats) (LDLR relative with 11 ligand-binding repeats) (LR11).

LRP5_HUMAN
θ value	0.000270298 (rank : 30)	NC score	0.342422 (rank : 23)
Query Neighborhood Hits	96	Target Neighborhood Hits	224	Shared Neighborhood Hits	66
SwissProt Accessions	O75197, Q96TD6, Q9UP66	Gene names	LRP5, LRP7
Domain Architecture
Description	Low-density lipoprotein receptor-related protein 5 precursor.

LRP1_HUMAN
θ value	0.00035302 (rank : 31)	NC score	0.286778 (rank : 42)
Query Neighborhood Hits	96	Target Neighborhood Hits	617	Shared Neighborhood Hits	71
SwissProt Accessions	Q07954, Q2PP12, Q8IVG8	Gene names	LRP1, A2MR
Domain Architecture
Description	Low-density lipoprotein receptor-related protein 1 precursor (LRP) (Alpha-2-macroglobulin receptor) (A2MR) (Apolipoprotein E receptor) (APOER) (CD91 antigen).

LRP8_HUMAN
θ value	0.00035302 (rank : 32)	NC score	0.318370 (rank : 26)
Query Neighborhood Hits	96	Target Neighborhood Hits	346	Shared Neighborhood Hits	69
SwissProt Accessions	Q14114, O14968, Q86V27, Q99876, Q9BR78	Gene names	LRP8, APOER2
Domain Architecture
Description	Low-density lipoprotein receptor-related protein 8 precursor (Apolipoprotein E receptor 2).

LRP8_MOUSE
θ value	0.00035302 (rank : 33)	NC score	0.314059 (rank : 33)
Query Neighborhood Hits	96	Target Neighborhood Hits	385	Shared Neighborhood Hits	69
SwissProt Accessions	Q924X6, Q8CAK9, Q8CDF5, Q921B6	Gene names	Lrp8, Apoer2
Domain Architecture
Description	Low-density lipoprotein receptor-related protein 8 precursor (Apolipoprotein E receptor 2).

LRP3_HUMAN
θ value	0.000461057 (rank : 34)	NC score	0.317692 (rank : 28)
Query Neighborhood Hits	96	Target Neighborhood Hits	280	Shared Neighborhood Hits	67
SwissProt Accessions	O75074	Gene names	LRP3
Domain Architecture
Description	Low-density lipoprotein receptor-related protein 3 precursor (hLRp105).

LRP6_HUMAN
θ value	0.000461057 (rank : 35)	NC score	0.339043 (rank : 25)
Query Neighborhood Hits	96	Target Neighborhood Hits	235	Shared Neighborhood Hits	67
SwissProt Accessions	O75581	Gene names	LRP6
Domain Architecture
Description	Low-density lipoprotein receptor-related protein 6 precursor.

LRP6_MOUSE
θ value	0.000461057 (rank : 36)	NC score	0.339528 (rank : 24)
Query Neighborhood Hits	96	Target Neighborhood Hits	232	Shared Neighborhood Hits	67
SwissProt Accessions	O88572	Gene names	Lrp6
Domain Architecture
Description	Low-density lipoprotein receptor-related protein 6 precursor.

TMPS9_HUMAN
θ value	0.000602161 (rank : 37)	NC score	0.121031 (rank : 85)
Query Neighborhood Hits	96	Target Neighborhood Hits	276	Shared Neighborhood Hits	61
SwissProt Accessions	Q7Z410, Q6ZND6, Q7Z411	Gene names	TMPRSS9
Domain Architecture	No domain graphic available
Description	Transmembrane protease, serine 9 (EC 3.4.21.-) (Polyserase-1) (Polyserase-I) (Polyserine protease 1) [Contains: Serase-1; Serase-2; Serase-3].

LDLR_MOUSE
θ value	0.000786445 (rank : 38)	NC score	0.313562 (rank : 34)
Query Neighborhood Hits	96	Target Neighborhood Hits	382	Shared Neighborhood Hits	69
SwissProt Accessions	P35951	Gene names	Ldlr
Domain Architecture
Description	Low-density lipoprotein receptor precursor (LDL receptor).

LRP2_HUMAN
θ value	0.000786445 (rank : 39)	NC score	0.306774 (rank : 39)
Query Neighborhood Hits	96	Target Neighborhood Hits	573	Shared Neighborhood Hits	70
SwissProt Accessions	P98164, O00711, Q16215	Gene names	LRP2
Domain Architecture
Description	Low-density lipoprotein receptor-related protein 2 precursor (Megalin) (Glycoprotein 330) (gp330).

LRP4_MOUSE
θ value	0.00134147 (rank : 40)	NC score	0.311020 (rank : 36)
Query Neighborhood Hits	96	Target Neighborhood Hits	351	Shared Neighborhood Hits	69
SwissProt Accessions	Q8VI56, Q8BPX5, Q8CBB3, Q8CCP5	Gene names	Lrp4, Kiaa0816
Domain Architecture
Description	Low-density lipoprotein receptor-related protein 4 precursor (LDLR dan).

CORIN_HUMAN
θ value	0.00175202 (rank : 41)	NC score	0.194016 (rank : 52)
Query Neighborhood Hits	96	Target Neighborhood Hits	453	Shared Neighborhood Hits	67
SwissProt Accessions	Q9Y5Q5, Q9UHY2	Gene names	CORIN, CRN, TMPRSS10
Domain Architecture
Description	Atrial natriuteric peptide-converting enzyme (EC 3.4.21.-) (pro-ANP- converting enzyme) (Corin) (Heart-specific serine proteinase ATC2) (Transmembrane protease, serine 10).

CO7A1_HUMAN
θ value	0.00228821 (rank : 42)	NC score	0.100525 (rank : 92)
Query Neighborhood Hits	96	Target Neighborhood Hits	807	Shared Neighborhood Hits	25
SwissProt Accessions	Q02388, Q14054, Q16507	Gene names	COL7A1
Domain Architecture
Description	Collagen alpha-1(VII) chain precursor (Long-chain collagen) (LC collagen).

ST14_MOUSE
θ value	0.00228821 (rank : 43)	NC score	0.193147 (rank : 53)
Query Neighborhood Hits	96	Target Neighborhood Hits	419	Shared Neighborhood Hits	67
SwissProt Accessions	P56677	Gene names	St14, Prss14
Domain Architecture
Description	Suppressor of tumorigenicity protein 14 (EC 3.4.21.-) (Serine protease 14) (Epithin).

TMPS9_MOUSE
θ value	0.00298849 (rank : 44)	NC score	0.115274 (rank : 87)
Query Neighborhood Hits	96	Target Neighborhood Hits	296	Shared Neighborhood Hits	56
SwissProt Accessions	P69525	Gene names	Tmprss9
Domain Architecture	No domain graphic available
Description	Transmembrane protease, serine 9 (EC 3.4.21.-) (Polyserase-1) (Polyserine protease 1) (Polyserase-I) [Contains: Serase-1; Serase-2; Serase-3].

LRP4_HUMAN
θ value	0.00390308 (rank : 45)	NC score	0.311167 (rank : 35)
Query Neighborhood Hits	96	Target Neighborhood Hits	355	Shared Neighborhood Hits	69
SwissProt Accessions	O75096	Gene names	LRP4, KIAA0816, MEGF7
Domain Architecture
Description	Low-density lipoprotein receptor-related protein 4 precursor (Multiple epidermal growth factor-like domains 7).

ENTK_MOUSE
θ value	0.00509761 (rank : 46)	NC score	0.133064 (rank : 75)
Query Neighborhood Hits	96	Target Neighborhood Hits	338	Shared Neighborhood Hits	63
SwissProt Accessions	P97435	Gene names	Prss7, Entk
Domain Architecture
Description	Enteropeptidase (EC 3.4.21.9) (Enterokinase) [Contains: Enteropeptidase non-catalytic heavy chain; Enteropeptidase catalytic light chain].

CORIN_MOUSE
θ value	0.0113563 (rank : 47)	NC score	0.189059 (rank : 54)
Query Neighborhood Hits	96	Target Neighborhood Hits	451	Shared Neighborhood Hits	67
SwissProt Accessions	Q9Z319	Gene names	Corin, Crn, Lrp4
Domain Architecture
Description	Atrial natriuteric peptide-converting enzyme (EC 3.4.21.-) (pro-ANP- converting enzyme) (Corin) (Low density lipoprotein receptor-related protein 4).

TMPS7_HUMAN
θ value	0.0113563 (rank : 48)	NC score	0.168347 (rank : 55)
Query Neighborhood Hits	96	Target Neighborhood Hits	275	Shared Neighborhood Hits	60
SwissProt Accessions	Q7RTY8	Gene names	TMPRSS7
Domain Architecture	No domain graphic available
Description	Transmembrane protease, serine 7 precursor (EC 3.4.21.-).

ENTK_HUMAN
θ value	0.0193708 (rank : 49)	NC score	0.129139 (rank : 79)
Query Neighborhood Hits	96	Target Neighborhood Hits	310	Shared Neighborhood Hits	61
SwissProt Accessions	P98073	Gene names	PRSS7, ENTK
Domain Architecture
Description	Enteropeptidase precursor (EC 3.4.21.9) (Enterokinase) [Contains: Enteropeptidase non-catalytic heavy chain; Enteropeptidase catalytic light chain].

LRP12_HUMAN
θ value	0.0193708 (rank : 50)	NC score	0.284990 (rank : 43)
Query Neighborhood Hits	96	Target Neighborhood Hits	205	Shared Neighborhood Hits	62
SwissProt Accessions	Q9Y561	Gene names	LRP12, ST7
Domain Architecture
Description	Low-density lipoprotein receptor-related protein 12 precursor (Suppressor of tumorigenicity protein 7).

PGBM_HUMAN
θ value	0.0193708 (rank : 51)	NC score	0.135869 (rank : 71)
Query Neighborhood Hits	96	Target Neighborhood Hits	1113	Shared Neighborhood Hits	69
SwissProt Accessions	P98160, Q16287, Q9H3V5	Gene names	HSPG2
Domain Architecture
Description	Basement membrane-specific heparan sulfate proteoglycan core protein precursor (HSPG) (Perlecan) (PLC).

CD320_HUMAN
θ value	0.0252991 (rank : 52)	NC score	0.398176 (rank : 20)
Query Neighborhood Hits	96	Target Neighborhood Hits	103	Shared Neighborhood Hits	63
SwissProt Accessions	Q9NPF0, Q53HF7	Gene names	CD320, 8D6A
Domain Architecture	No domain graphic available
Description	CD320 antigen precursor (8D6 antigen) (FDC-signaling molecule 8D6) (FDC-SM-8D6).

WFDC6_HUMAN
θ value	0.0252991 (rank : 53)	NC score	0.364053 (rank : 21)
Query Neighborhood Hits	96	Target Neighborhood Hits	33	Shared Neighborhood Hits	20
SwissProt Accessions	Q9BQY6, Q5JYQ4, Q8NFV6	Gene names	WFDC6, C20orf171, WAP6
Domain Architecture
Description	WAP four-disulfide core domain protein 6 precursor (Putative protease inhibitor WAP6).

MANS1_HUMAN
θ value	0.0431538 (rank : 54)	NC score	0.125039 (rank : 83)
Query Neighborhood Hits	96	Target Neighborhood Hits	44	Shared Neighborhood Hits	5
SwissProt Accessions	Q9H8J5, Q8NEC1	Gene names	MANSC1
Domain Architecture	No domain graphic available
Description	MANSC domain-containing protein 1 precursor.

SSPO_MOUSE
θ value	0.0431538 (rank : 55)	NC score	0.212185 (rank : 48)
Query Neighborhood Hits	96	Target Neighborhood Hits	800	Shared Neighborhood Hits	70
SwissProt Accessions	Q8CG65	Gene names	Sspo
Domain Architecture	No domain graphic available
Description	SCO-spondin precursor.

FBN1_MOUSE
θ value	0.0563607 (rank : 56)	NC score	0.087750 (rank : 97)
Query Neighborhood Hits	96	Target Neighborhood Hits	563	Shared Neighborhood Hits	43
SwissProt Accessions	Q61554, Q60826	Gene names	Fbn1, Fbn-1
Domain Architecture
Description	Fibrillin-1 precursor.

MANS1_MOUSE
θ value	0.0563607 (rank : 57)	NC score	0.134600 (rank : 73)
Query Neighborhood Hits	96	Target Neighborhood Hits	19	Shared Neighborhood Hits	4
SwissProt Accessions	Q9CR33, Q80V71	Gene names	Mansc1
Domain Architecture	No domain graphic available
Description	MANSC domain-containing protein 1 precursor.

TMPS7_MOUSE
θ value	0.0563607 (rank : 58)	NC score	0.167420 (rank : 57)
Query Neighborhood Hits	96	Target Neighborhood Hits	275	Shared Neighborhood Hits	63
SwissProt Accessions	Q8BIK6	Gene names	Tmprss7
Domain Architecture	No domain graphic available
Description	Transmembrane protease, serine 7 precursor (EC 3.4.21.-).

LRP12_MOUSE
θ value	0.0736092 (rank : 59)	NC score	0.280451 (rank : 44)
Query Neighborhood Hits	96	Target Neighborhood Hits	180	Shared Neighborhood Hits	62
SwissProt Accessions	Q8BUJ9, Q8BWM9	Gene names	Lrp12
Domain Architecture
Description	Low-density lipoprotein receptor-related protein 12 precursor.

STAB2_HUMAN
θ value	0.0961366 (rank : 60)	NC score	0.065582 (rank : 164)
Query Neighborhood Hits	96	Target Neighborhood Hits	534	Shared Neighborhood Hits	39
SwissProt Accessions	Q8WWQ8, Q6ZMK2, Q7Z5N9, Q86UR4, Q8IUG9, Q8TES1, Q9H7H7, Q9NRY3	Gene names	STAB2, FEEL2, FELL, FEX2, HARE
Domain Architecture	No domain graphic available
Description	Stabilin-2 precursor (FEEL-2 protein) (Fasciclin EGF-like laminin-type EGF-like and link domain-containing scavenger receptor 1) (FAS1 EGF- like and X-link domain-containing adhesion molecule 2) (Hyaluronan receptor for endocytosis) [Contains: 190 kDa form stabilin-2 (190 kDa hyaluronan receptor for endocytosis)].

CFAI_HUMAN
θ value	0.125558 (rank : 61)	NC score	0.153965 (rank : 61)
Query Neighborhood Hits	96	Target Neighborhood Hits	289	Shared Neighborhood Hits	63
SwissProt Accessions	P05156, O60442	Gene names	CFI, IF
Domain Architecture
Description	Complement factor I precursor (EC 3.4.21.45) (C3B/C4B inactivator) [Contains: Complement factor I heavy chain; Complement factor I light chain].

CFAI_MOUSE
θ value	0.163984 (rank : 62)	NC score	0.141132 (rank : 69)
Query Neighborhood Hits	96	Target Neighborhood Hits	290	Shared Neighborhood Hits	63
SwissProt Accessions	Q61129, Q9WU07	Gene names	Cfi, If
Domain Architecture
Description	Complement factor I precursor (EC 3.4.21.45) (C3B/C4B inactivator) [Contains: Complement factor I heavy chain; Complement factor I light chain].

MFRP_HUMAN
θ value	0.163984 (rank : 63)	NC score	0.168281 (rank : 56)
Query Neighborhood Hits	96	Target Neighborhood Hits	165	Shared Neighborhood Hits	57
SwissProt Accessions	Q9BY79, Q335M3, Q96DQ9	Gene names	MFRP
Domain Architecture	No domain graphic available
Description	Membrane frizzled-related protein (Membrane-type frizzled-related protein).

PGBM_MOUSE
θ value	0.163984 (rank : 64)	NC score	0.139380 (rank : 70)
Query Neighborhood Hits	96	Target Neighborhood Hits	1073	Shared Neighborhood Hits	71
SwissProt Accessions	Q05793	Gene names	Hspg2
Domain Architecture
Description	Basement membrane-specific heparan sulfate proteoglycan core protein precursor (HSPG) (Perlecan) (PLC).

FBN1_HUMAN
θ value	0.21417 (rank : 65)	NC score	0.084423 (rank : 102)
Query Neighborhood Hits	96	Target Neighborhood Hits	557	Shared Neighborhood Hits	37
SwissProt Accessions	P35555, Q15972, Q75N87	Gene names	FBN1, FBN
Domain Architecture
Description	Fibrillin-1 precursor.

TMPS6_MOUSE
θ value	0.21417 (rank : 66)	NC score	0.144554 (rank : 66)
Query Neighborhood Hits	96	Target Neighborhood Hits	341	Shared Neighborhood Hits	66
SwissProt Accessions	Q9DBI0, Q6PF94	Gene names	Tmprss6
Domain Architecture
Description	Transmembrane protease, serine 6 (EC 3.4.21.-) (Matriptase-2).

LRP10_HUMAN
θ value	0.279714 (rank : 67)	NC score	0.317837 (rank : 27)
Query Neighborhood Hits	96	Target Neighborhood Hits	197	Shared Neighborhood Hits	65
SwissProt Accessions	Q7Z4F1, O95882, Q86T02, Q8NCZ4, Q9HC42, Q9UG33	Gene names	LRP10
Domain Architecture
Description	Low-density lipoprotein receptor-related protein 10 precursor.

LRP10_MOUSE
θ value	0.279714 (rank : 68)	NC score	0.317379 (rank : 29)
Query Neighborhood Hits	96	Target Neighborhood Hits	169	Shared Neighborhood Hits	65
SwissProt Accessions	Q7TQH7, Q7TS95, Q921T0, Q9EPE8	Gene names	Lrp10, Lrp9
Domain Architecture
Description	Low-density lipoprotein receptor-related protein 10 precursor.

CO6_HUMAN
θ value	0.365318 (rank : 69)	NC score	0.162558 (rank : 59)
Query Neighborhood Hits	96	Target Neighborhood Hits	331	Shared Neighborhood Hits	66
SwissProt Accessions	P13671	Gene names	C6
Domain Architecture
Description	Complement component C6 precursor.

MFRP_MOUSE
θ value	0.365318 (rank : 70)	NC score	0.153040 (rank : 62)
Query Neighborhood Hits	96	Target Neighborhood Hits	166	Shared Neighborhood Hits	59
SwissProt Accessions	Q8K480, Q8BPP4	Gene names	Mfrp
Domain Architecture	No domain graphic available
Description	Membrane frizzled-related protein (Membrane-type frizzled-related protein).

CO9_MOUSE
θ value	0.62314 (rank : 71)	NC score	0.203345 (rank : 50)
Query Neighborhood Hits	96	Target Neighborhood Hits	153	Shared Neighborhood Hits	59
SwissProt Accessions	P06683, Q91XA7	Gene names	C9
Domain Architecture
Description	Complement component C9 precursor.

K0319_HUMAN
θ value	0.813845 (rank : 72)	NC score	0.127391 (rank : 80)
Query Neighborhood Hits	96	Target Neighborhood Hits	154	Shared Neighborhood Hits	10
SwissProt Accessions	Q5VV43, Q9UJC8, Q9Y4G7	Gene names	KIAA0319
Domain Architecture	No domain graphic available
Description	Protein KIAA0319 precursor.

SREC_HUMAN
θ value	0.813845 (rank : 73)	NC score	0.060414 (rank : 189)
Query Neighborhood Hits	96	Target Neighborhood Hits	645	Shared Neighborhood Hits	40
SwissProt Accessions	Q14162, O43701	Gene names	SCARF1, KIAA0149, SREC
Domain Architecture	No domain graphic available
Description	Endothelial cells scavenger receptor precursor (Acetyl LDL receptor) (Scavenger receptor class F member 1).

TMPS6_HUMAN
θ value	0.813845 (rank : 74)	NC score	0.148247 (rank : 63)
Query Neighborhood Hits	96	Target Neighborhood Hits	338	Shared Neighborhood Hits	66
SwissProt Accessions	Q8IU80, Q5TI06, Q6UXD8, Q8IUE2, Q8IXV8	Gene names	TMPRSS6
Domain Architecture
Description	Transmembrane protease, serine 6 (EC 3.4.21.-) (Matriptase-2).

TEX2_HUMAN
θ value	1.06291 (rank : 75)	NC score	0.027028 (rank : 284)
Query Neighborhood Hits	96	Target Neighborhood Hits	106	Shared Neighborhood Hits	2
SwissProt Accessions	Q8IWB9, Q6AHZ5, Q8N3L0, Q9C0C5	Gene names	TEX2, KIAA1738
Domain Architecture	No domain graphic available
Description	Testis-expressed sequence 2 protein.

TMPS2_MOUSE
θ value	1.06291 (rank : 76)	NC score	0.097735 (rank : 93)
Query Neighborhood Hits	96	Target Neighborhood Hits	243	Shared Neighborhood Hits	57
SwissProt Accessions	Q9JIQ8, Q9JKC4, Q9QY82	Gene names	Tmprss2
Domain Architecture
Description	Transmembrane protease, serine 2 (EC 3.4.21.-) (Epitheliasin) (Plasmic transmembrane protein X) [Contains: Transmembrane protease, serine 2 non-catalytic chain; Transmembrane protease, serine 2 catalytic chain].

ZAN_MOUSE
θ value	1.06291 (rank : 77)	NC score	0.084788 (rank : 101)
Query Neighborhood Hits	96	Target Neighborhood Hits	808	Shared Neighborhood Hits	39
SwissProt Accessions	O88799, O08647	Gene names	Zan
Domain Architecture
Description	Zonadhesin precursor.

ELTD1_MOUSE
θ value	1.38821 (rank : 78)	NC score	0.048285 (rank : 283)
Query Neighborhood Hits	96	Target Neighborhood Hits	288	Shared Neighborhood Hits	20
SwissProt Accessions	Q923X1, Q91W44	Gene names	Eltd1
Domain Architecture
Description	EGF, latrophilin seven transmembrane domain-containing protein 1 precursor.

ERBB3_MOUSE
θ value	1.38821 (rank : 79)	NC score	0.004979 (rank : 286)
Query Neighborhood Hits	96	Target Neighborhood Hits	898	Shared Neighborhood Hits	12
SwissProt Accessions	Q61526, Q3KQR1, Q68J64, Q810U8, Q8K317	Gene names	Erbb3
Domain Architecture	No domain graphic available
Description	Receptor tyrosine-protein kinase erbB-3 precursor (EC 2.7.10.1) (c- erbB3) (Glial growth factor receptor).

CO9_HUMAN
θ value	1.81305 (rank : 80)	NC score	0.225874 (rank : 45)
Query Neighborhood Hits	96	Target Neighborhood Hits	147	Shared Neighborhood Hits	61
SwissProt Accessions	P02748	Gene names	C9
Domain Architecture
Description	Complement component C9 precursor [Contains: Complement component C9a; Complement component C9b].

CO7_HUMAN
θ value	2.36792 (rank : 81)	NC score	0.123106 (rank : 84)
Query Neighborhood Hits	96	Target Neighborhood Hits	278	Shared Neighborhood Hits	56
SwissProt Accessions	P10643, Q6P3T5, Q92489	Gene names	C7
Domain Architecture
Description	Complement component C7 precursor.

K0319_MOUSE
θ value	2.36792 (rank : 82)	NC score	0.117088 (rank : 86)
Query Neighborhood Hits	96	Target Neighborhood Hits	134	Shared Neighborhood Hits	8
SwissProt Accessions	Q5SZV5, Q80U39	Gene names	Kiaa0319
Domain Architecture	No domain graphic available
Description	Protein KIAA0319 precursor.

CO8B_MOUSE
θ value	3.0926 (rank : 83)	NC score	0.132319 (rank : 77)
Query Neighborhood Hits	96	Target Neighborhood Hits	224	Shared Neighborhood Hits	61
SwissProt Accessions	Q8BH35, Q4VAH1, Q8CHJ5, Q8CHJ6, Q8VC14	Gene names	C8b
Domain Architecture	No domain graphic available
Description	Complement component C8 beta chain precursor (Complement component 8 subunit beta).

ALK_MOUSE
θ value	4.03905 (rank : 84)	NC score	0.008913 (rank : 285)
Query Neighborhood Hits	96	Target Neighborhood Hits	811	Shared Neighborhood Hits	29
SwissProt Accessions	P97793	Gene names	Alk
Domain Architecture
Description	ALK tyrosine kinase receptor precursor (EC 2.7.10.1) (Anaplastic lymphoma kinase) (CD246 antigen).

CAD12_HUMAN
θ value	4.03905 (rank : 85)	NC score	0.003025 (rank : 287)
Query Neighborhood Hits	96	Target Neighborhood Hits	154	Shared Neighborhood Hits	3
SwissProt Accessions	P55289	Gene names	CDH12
Domain Architecture
Description	Cadherin-12 precursor (Brain-cadherin) (BR-cadherin) (N-cadherin 2) (Neural type cadherin 2).

CR001_HUMAN
θ value	4.03905 (rank : 86)	NC score	0.145940 (rank : 64)
Query Neighborhood Hits	96	Target Neighborhood Hits	68	Shared Neighborhood Hits	50
SwissProt Accessions	O15165, O15166, O15167, O15168, Q6NXP3	Gene names	C18orf1
Domain Architecture
Description	Protein C18orf1.

CR001_MOUSE
θ value	4.03905 (rank : 87)	NC score	0.144166 (rank : 67)
Query Neighborhood Hits	96	Target Neighborhood Hits	67	Shared Neighborhood Hits	50
SwissProt Accessions	Q8BWJ4	Gene names	D18Ertd653e
Domain Architecture	No domain graphic available
Description	Protein C18orf1 homolog.

IDD_MOUSE
θ value	4.03905 (rank : 88)	NC score	0.207557 (rank : 49)
Query Neighborhood Hits	96	Target Neighborhood Hits	151	Shared Neighborhood Hits	54
SwissProt Accessions	P98154, Q61844	Gene names	Dgcr2, Dgsc, Idd, Sez-12, Sez12
Domain Architecture
Description	Integral membrane protein DGCR2/IDD precursor (Seizure-related membrane-bound adhesion protein).

RXFP2_MOUSE
θ value	4.03905 (rank : 89)	NC score	0.055696 (rank : 226)
Query Neighborhood Hits	96	Target Neighborhood Hits	760	Shared Neighborhood Hits	58
SwissProt Accessions	Q91ZZ5	Gene names	Rxfp2, Gpr106, Great, Lgr8
Domain Architecture
Description	Relaxin receptor 2 (Relaxin family peptide receptor 2) (Leucine-rich repeat-containing G-protein coupled receptor 8) (G-protein coupled receptor affecting testicular descent) (G-protein coupled receptor 106).

TMPS3_HUMAN
θ value	4.03905 (rank : 90)	NC score	0.086611 (rank : 99)
Query Neighborhood Hits	96	Target Neighborhood Hits	245	Shared Neighborhood Hits	59
SwissProt Accessions	P57727, Q6ZMC3	Gene names	TMPRSS3, ECHOS1, TADG12
Domain Architecture
Description	Transmembrane protease, serine 3 (EC 3.4.21.-) (Serine protease TADG- 12) (Tumor-associated differentially-expressed gene 12 protein).

CAD10_HUMAN
θ value	5.27518 (rank : 91)	NC score	0.002673 (rank : 288)
Query Neighborhood Hits	96	Target Neighborhood Hits	162	Shared Neighborhood Hits	3
SwissProt Accessions	Q9Y6N8, Q9ULB3	Gene names	CDH10
Domain Architecture
Description	Cadherin-10 precursor (T2-cadherin).

CO8B_HUMAN
θ value	5.27518 (rank : 92)	NC score	0.132984 (rank : 76)
Query Neighborhood Hits	96	Target Neighborhood Hits	199	Shared Neighborhood Hits	60
SwissProt Accessions	P07358	Gene names	C8B
Domain Architecture
Description	Complement component C8 beta chain precursor (Complement component 8 subunit beta).

GNAS1_MOUSE
θ value	6.88961 (rank : 93)	NC score	0.002199 (rank : 289)
Query Neighborhood Hits	96	Target Neighborhood Hits	651	Shared Neighborhood Hits	4
SwissProt Accessions	Q6R0H7, Q6R0H4, Q6R0H5, Q6R2J5, Q9JJX0, Q9Z1N8	Gene names	Gnas, Gnas1
Domain Architecture	No domain graphic available
Description	Guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas (Adenylate cyclase-stimulating G alpha protein) (Extra large alphas protein) (XLalphas).

IDD_HUMAN
θ value	6.88961 (rank : 94)	NC score	0.219776 (rank : 46)
Query Neighborhood Hits	96	Target Neighborhood Hits	127	Shared Neighborhood Hits	57
SwissProt Accessions	P98153	Gene names	DGCR2, IDD, KIAA0163
Domain Architecture
Description	Integral membrane protein DGCR2/IDD precursor.

CO8A_MOUSE
θ value	8.99809 (rank : 95)	NC score	0.145834 (rank : 65)
Query Neighborhood Hits	96	Target Neighborhood Hits	182	Shared Neighborhood Hits	61
SwissProt Accessions	Q8K182, Q8CHJ9, Q8CHK1	Gene names	C8a
Domain Architecture	No domain graphic available
Description	Complement component C8 alpha chain precursor (Complement component 8 subunit alpha).

RXFP2_HUMAN
θ value	8.99809 (rank : 96)	NC score	0.058994 (rank : 200)
Query Neighborhood Hits	96	Target Neighborhood Hits	736	Shared Neighborhood Hits	56
SwissProt Accessions	Q8WXD0	Gene names	RXFP2, GPR106, GREAT, LGR8
Domain Architecture
Description	Relaxin receptor 2 (Relaxin family peptide receptor 2) (Leucine-rich repeat-containing G-protein coupled receptor 8) (G-protein coupled receptor affecting testicular descent) (G-protein coupled receptor 106).

ACRO_HUMAN
θ value	θ > 10 (rank : 97)	NC score	0.056114 (rank : 223)
Query Neighborhood Hits	96	Target Neighborhood Hits	291	Shared Neighborhood Hits	16
SwissProt Accessions	P10323, Q6ICK2	Gene names	ACR, ACRS
Domain Architecture
Description	Acrosin precursor (EC 3.4.21.10) [Contains: Acrosin light chain; Acrosin heavy chain].

ACRO_MOUSE
θ value	θ > 10 (rank : 98)	NC score	0.054917 (rank : 237)
Query Neighborhood Hits	96	Target Neighborhood Hits	185	Shared Neighborhood Hits	16
SwissProt Accessions	P23578	Gene names	Acr
Domain Architecture
Description	Acrosin precursor (EC 3.4.21.10) [Contains: Acrosin light chain; Acrosin heavy chain].

APLP1_HUMAN
θ value	θ > 10 (rank : 99)	NC score	0.109135 (rank : 89)
Query Neighborhood Hits	96	Target Neighborhood Hits	85	Shared Neighborhood Hits	3
SwissProt Accessions	P51693, O00113, Q96A92	Gene names	APLP1
Domain Architecture
Description	Amyloid-like protein 1 precursor (APLP) (APLP-1) [Contains: C30].

APLP1_MOUSE
θ value	θ > 10 (rank : 100)	NC score	0.108860 (rank : 90)
Query Neighborhood Hits	96	Target Neighborhood Hits	130	Shared Neighborhood Hits	3
SwissProt Accessions	Q03157, Q8VC38	Gene names	Aplp1
Domain Architecture
Description	Amyloid-like protein 1 precursor (APLP) (APLP-1) [Contains: C30].

APLP2_MOUSE
θ value	θ > 10 (rank : 101)	NC score	0.129747 (rank : 78)
Query Neighborhood Hits	96	Target Neighborhood Hits	186	Shared Neighborhood Hits	3
SwissProt Accessions	Q06335	Gene names	Aplp2
Domain Architecture
Description	Amyloid-like protein 2 precursor (CDEI box-binding protein) (CDEBP).

BMP1_HUMAN
θ value	θ > 10 (rank : 102)	NC score	0.065549 (rank : 165)
Query Neighborhood Hits	96	Target Neighborhood Hits	233	Shared Neighborhood Hits	35
SwissProt Accessions	P13497, Q13292, Q13872, Q14874, Q99421, Q99422, Q99423, Q9UL38	Gene names	BMP1, PCOLC
Domain Architecture
Description	Bone morphogenetic protein 1 precursor (EC 3.4.24.19) (BMP-1) (Procollagen C-proteinase) (PCP) (Mammalian tolloid protein) (mTld).

BMP1_MOUSE
θ value	θ > 10 (rank : 103)	NC score	0.066143 (rank : 161)
Query Neighborhood Hits	96	Target Neighborhood Hits	236	Shared Neighborhood Hits	35
SwissProt Accessions	P98063	Gene names	Bmp1
Domain Architecture
Description	Bone morphogenetic protein 1 precursor (EC 3.4.24.19) (BMP-1) (Procollagen C-proteinase) (PCP) (Mammalian tolloid protein) (mTld).

BSSP4_HUMAN
θ value	θ > 10 (rank : 104)	NC score	0.054427 (rank : 243)
Query Neighborhood Hits	96	Target Neighborhood Hits	176	Shared Neighborhood Hits	16
SwissProt Accessions	Q9GZN4, O43342, Q6UXE0	Gene names	PRSS22, BSSP4, PRSS26
Domain Architecture
Description	Brain-specific serine protease 4 precursor (EC 3.4.21.-) (BSSP-4) (Serine protease 22) (Tryptase epsilon).

BSSP4_MOUSE
θ value	θ > 10 (rank : 105)	NC score	0.053347 (rank : 254)
Query Neighborhood Hits	96	Target Neighborhood Hits	179	Shared Neighborhood Hits	16
SwissProt Accessions	Q9ER10	Gene names	Prss22, Bssp4, Prss26
Domain Architecture
Description	Brain-specific serine protease 4 precursor (EC 3.4.21.-) (BSSP-4) (Serine protease 22) (Tryptase epsilon).

C1QR1_HUMAN
θ value	θ > 10 (rank : 106)	NC score	0.072173 (rank : 134)
Query Neighborhood Hits	96	Target Neighborhood Hits	493	Shared Neighborhood Hits	32
SwissProt Accessions	Q9NPY3, O00274	Gene names	CD93, C1QR1, MXRA4
Domain Architecture
Description	Complement component C1q receptor precursor (Complement component 1 q subcomponent receptor 1) (C1qR) (C1qRp) (C1qR(p)) (C1q/MBL/SPA receptor) (CD93 antigen) (CDw93).

C1QR1_MOUSE
θ value	θ > 10 (rank : 107)	NC score	0.067862 (rank : 152)
Query Neighborhood Hits	96	Target Neighborhood Hits	342	Shared Neighborhood Hits	28
SwissProt Accessions	O89103, Q3U2X0	Gene names	Cd93, Aa4, C1qr1, C1qrp, Ly68
Domain Architecture
Description	Complement component C1q receptor precursor (Complement component 1 q subcomponent receptor 1) (C1qRp) (C1qR(p)) (C1q/MBL/SPA receptor) (CD93 antigen) (Cell surface antigen AA4) (Lymphocyte antigen 68).

C1RA_MOUSE
θ value	θ > 10 (rank : 108)	NC score	0.068815 (rank : 148)
Query Neighborhood Hits	96	Target Neighborhood Hits	379	Shared Neighborhood Hits	41
SwissProt Accessions	Q8CG16, Q99KI6, Q9ET60	Gene names	C1ra, C1r
Domain Architecture
Description	Complement C1r-A subcomponent precursor (EC 3.4.21.41) (Complement component 1, r-A subcomponent) [Contains: Complement C1r-A subcomponent heavy chain; Complement C1r-A subcomponent light chain].

C1RB_MOUSE
θ value	θ > 10 (rank : 109)	NC score	0.068322 (rank : 149)
Query Neighborhood Hits	96	Target Neighborhood Hits	380	Shared Neighborhood Hits	40
SwissProt Accessions	Q8CFG9	Gene names	C1rb, C1r
Domain Architecture	No domain graphic available
Description	Complement C1r-B subcomponent precursor (EC 3.4.21.41) (Complement component 1, r-B subcomponent) [Contains: Complement C1r-B subcomponent heavy chain; Complement C1r-B subcomponent light chain].

C1R_HUMAN
θ value	θ > 10 (rank : 110)	NC score	0.069167 (rank : 146)
Query Neighborhood Hits	96	Target Neighborhood Hits	364	Shared Neighborhood Hits	40
SwissProt Accessions	P00736, Q8J012	Gene names	C1R
Domain Architecture
Description	Complement C1r subcomponent precursor (EC 3.4.21.41) (Complement component 1, r subcomponent) [Contains: Complement C1r subcomponent heavy chain; Complement C1r subcomponent light chain].

C1S_HUMAN
θ value	θ > 10 (rank : 111)	NC score	0.063535 (rank : 177)
Query Neighborhood Hits	96	Target Neighborhood Hits	359	Shared Neighborhood Hits	39
SwissProt Accessions	P09871, Q9UCU7, Q9UCU8, Q9UCU9, Q9UCV0, Q9UCV1, Q9UCV2, Q9UCV3, Q9UCV4, Q9UCV5, Q9UM14	Gene names	C1S
Domain Architecture
Description	Complement C1s subcomponent precursor (EC 3.4.21.42) (C1 esterase) [Contains: Complement C1s subcomponent heavy chain; Complement C1s subcomponent light chain].

CD248_HUMAN
θ value	θ > 10 (rank : 112)	NC score	0.079740 (rank : 106)
Query Neighborhood Hits	96	Target Neighborhood Hits	679	Shared Neighborhood Hits	28
SwissProt Accessions	Q9HCU0, Q3SX55, Q96KB6	Gene names	CD248, CD164L1, TEM1
Domain Architecture	No domain graphic available
Description	Endosialin precursor (Tumor endothelial marker 1) (CD248 antigen).

CD248_MOUSE
θ value	θ > 10 (rank : 113)	NC score	0.078959 (rank : 108)
Query Neighborhood Hits	96	Target Neighborhood Hits	578	Shared Neighborhood Hits	28
SwissProt Accessions	Q91V98, Q3UMV6, Q91ZV1	Gene names	Cd248, Tem1
Domain Architecture	No domain graphic available
Description	Endosialin precursor (Tumor endothelial marker 1) (CD248 antigen).

CLCR_HUMAN
θ value	θ > 10 (rank : 114)	NC score	0.052949 (rank : 256)
Query Neighborhood Hits	96	Target Neighborhood Hits	177	Shared Neighborhood Hits	16
SwissProt Accessions	Q99895, O00765, Q9NUH5	Gene names	CTRC, CLCR
Domain Architecture
Description	Caldecrin precursor (EC 3.4.21.2) (Chymotrypsin C).

CO8A_HUMAN
θ value	θ > 10 (rank : 115)	NC score	0.142517 (rank : 68)
Query Neighborhood Hits	96	Target Neighborhood Hits	200	Shared Neighborhood Hits	60
SwissProt Accessions	P07357, Q13668, Q9H130	Gene names	C8A
Domain Architecture
Description	Complement component C8 alpha chain precursor (Complement component 8 subunit alpha).

CO8G_HUMAN
θ value	θ > 10 (rank : 116)	NC score	0.058681 (rank : 202)
Query Neighborhood Hits	96	Target Neighborhood Hits	10	Shared Neighborhood Hits	2
SwissProt Accessions	P07360, Q5SQ07	Gene names	C8G
Domain Architecture
Description	Complement component C8 gamma chain precursor.

CO8G_MOUSE
θ value	θ > 10 (rank : 117)	NC score	0.061984 (rank : 182)
Query Neighborhood Hits	96	Target Neighborhood Hits	15	Shared Neighborhood Hits	2
SwissProt Accessions	Q8VCG4	Gene names	C8g
Domain Architecture
Description	Complement component C8 gamma chain precursor.

CREL1_HUMAN
θ value	θ > 10 (rank : 118)	NC score	0.065054 (rank : 168)
Query Neighborhood Hits	96	Target Neighborhood Hits	441	Shared Neighborhood Hits	26
SwissProt Accessions	Q96HD1, Q6I9X5, Q8NFT4, Q9Y409	Gene names	CRELD1, CIRRIN
Domain Architecture	No domain graphic available
Description	Cysteine-rich with EGF-like domain protein 1 precursor.

CREL1_MOUSE
θ value	θ > 10 (rank : 119)	NC score	0.063944 (rank : 173)
Query Neighborhood Hits	96	Target Neighborhood Hits	524	Shared Neighborhood Hits	27
SwissProt Accessions	Q91XD7, Q8BGJ8	Gene names	Creld1
Domain Architecture	No domain graphic available
Description	Cysteine-rich with EGF-like domain protein 1 precursor.

CRUM1_HUMAN
θ value	θ > 10 (rank : 120)	NC score	0.056265 (rank : 221)
Query Neighborhood Hits	96	Target Neighborhood Hits	457	Shared Neighborhood Hits	38
SwissProt Accessions	P82279, Q5K3A6, Q5TC28, Q5VUT1, Q6N027, Q8WWY0	Gene names	CRB1
Domain Architecture
Description	Crumbs homolog 1 precursor.

CRUM1_MOUSE
θ value	θ > 10 (rank : 121)	NC score	0.054616 (rank : 241)
Query Neighborhood Hits	96	Target Neighborhood Hits	444	Shared Neighborhood Hits	40
SwissProt Accessions	Q8VHS2, Q6ST50, Q71JF2, Q8BGR4	Gene names	Crb1
Domain Architecture	No domain graphic available
Description	Crumbs homolog 1 precursor.

CS1A_MOUSE
θ value	θ > 10 (rank : 122)	NC score	0.063802 (rank : 175)
Query Neighborhood Hits	96	Target Neighborhood Hits	360	Shared Neighborhood Hits	40
SwissProt Accessions	Q8CG14, Q8BJC4, Q8CH28, Q8VBY4	Gene names	C1sa, C1s
Domain Architecture	No domain graphic available
Description	Complement C1s-A subcomponent precursor (EC 3.4.21.42) (C1 esterase) [Contains: Complement C1s-A subcomponent heavy chain; Complement C1s-A subcomponent light chain].

CS1B_MOUSE
θ value	θ > 10 (rank : 123)	NC score	0.065332 (rank : 167)
Query Neighborhood Hits	96	Target Neighborhood Hits	361	Shared Neighborhood Hits	40
SwissProt Accessions	Q8CFG8	Gene names	C1sb, C1s
Domain Architecture	No domain graphic available
Description	Complement C1s-B subcomponent precursor (EC 3.4.21.42) (C1 esterase) [Contains: Complement C1s-B subcomponent heavy chain; Complement C1s-B subcomponent light chain].

CTRB1_HUMAN
θ value	θ > 10 (rank : 124)	NC score	0.053028 (rank : 255)
Query Neighborhood Hits	96	Target Neighborhood Hits	176	Shared Neighborhood Hits	16
SwissProt Accessions	P17538	Gene names	CTRB1, CTRB
Domain Architecture
Description	Chymotrypsinogen B precursor (EC 3.4.21.1) [Contains: Chymotrypsin B chain A; Chymotrypsin B chain B; Chymotrypsin B chain C].

CTRL_HUMAN
θ value	θ > 10 (rank : 125)	NC score	0.052717 (rank : 258)
Query Neighborhood Hits	96	Target Neighborhood Hits	179	Shared Neighborhood Hits	16
SwissProt Accessions	P40313	Gene names	CTRL, CTRL1
Domain Architecture
Description	Chymotrypsin-like protease CTRL-1 precursor (EC 3.4.21.-).

CUBN_HUMAN
θ value	θ > 10 (rank : 126)	NC score	0.060584 (rank : 185)
Query Neighborhood Hits	96	Target Neighborhood Hits	482	Shared Neighborhood Hits	46
SwissProt Accessions	O60494, Q5VTA6, Q96RU9	Gene names	CUBN, IFCR
Domain Architecture	No domain graphic available
Description	Cubilin precursor (Intrinsic factor-cobalamin receptor) (Intrinsic factor-vitamin B12 receptor) (460 kDa receptor) (Intestinal intrinsic factor receptor).

CUBN_MOUSE
θ value	θ > 10 (rank : 127)	NC score	0.067778 (rank : 153)
Query Neighborhood Hits	96	Target Neighborhood Hits	477	Shared Neighborhood Hits	46
SwissProt Accessions	Q9JLB4	Gene names	Cubn, Ifcr
Domain Architecture	No domain graphic available
Description	Cubilin precursor (Intrinsic factor-cobalamin receptor).

DESC4_MOUSE
θ value	θ > 10 (rank : 128)	NC score	0.057736 (rank : 209)
Query Neighborhood Hits	96	Target Neighborhood Hits	176	Shared Neighborhood Hits	16
SwissProt Accessions	Q8BZ10, Q8BZ04	Gene names	Desc4
Domain Architecture	No domain graphic available
Description	Serine protease DESC4 precursor (EC 3.4.21.-) [Contains: Serine protease DESC4 non-catalytic chain; Serine protease DESC4 catalytic chain].

DLL1_HUMAN
θ value	θ > 10 (rank : 129)	NC score	0.059952 (rank : 193)
Query Neighborhood Hits	96	Target Neighborhood Hits	455	Shared Neighborhood Hits	44
SwissProt Accessions	O00548, Q9NU41, Q9UJV2	Gene names	DLL1
Domain Architecture
Description	Delta-like protein 1 precursor (Drosophila Delta homolog 1) (Delta1) (H-Delta-1).

DLL1_MOUSE
θ value	θ > 10 (rank : 130)	NC score	0.057466 (rank : 211)
Query Neighborhood Hits	96	Target Neighborhood Hits	456	Shared Neighborhood Hits	40
SwissProt Accessions	Q61483	Gene names	Dll1
Domain Architecture
Description	Delta-like protein 1 precursor (Drosophila Delta homolog 1) (Delta1).

DLL4_HUMAN
θ value	θ > 10 (rank : 131)	NC score	0.052226 (rank : 262)
Query Neighborhood Hits	96	Target Neighborhood Hits	435	Shared Neighborhood Hits	39
SwissProt Accessions	Q9NR61, Q9NQT9	Gene names	DLL4
Domain Architecture
Description	Delta-like protein 4 precursor (Drosophila Delta homolog 4).

DLL4_MOUSE
θ value	θ > 10 (rank : 132)	NC score	0.051297 (rank : 274)
Query Neighborhood Hits	96	Target Neighborhood Hits	440	Shared Neighborhood Hits	34
SwissProt Accessions	Q9JI71, Q9JHZ7	Gene names	Dll4
Domain Architecture
Description	Delta-like protein 4 precursor (Drosophila Delta homolog 4).

EGFL7_HUMAN
θ value	θ > 10 (rank : 133)	NC score	0.054778 (rank : 238)
Query Neighborhood Hits	96	Target Neighborhood Hits	325	Shared Neighborhood Hits	24
SwissProt Accessions	Q9UHF1, Q5M7Y5, Q5VUD5, Q96EG0	Gene names	EGFL7, MEGF7
Domain Architecture	No domain graphic available
Description	EGF-like domain-containing protein 7 precursor (Multiple EGF-like domain protein 7) (Multiple epidermal growth factor-like domain protein 7) (Vascular endothelial statin) (VE-statin) (NOTCH4-like protein) (ZNEU1).

EGF_HUMAN
θ value	θ > 10 (rank : 134)	NC score	0.164456 (rank : 58)
Query Neighborhood Hits	96	Target Neighborhood Hits	343	Shared Neighborhood Hits	31
SwissProt Accessions	P01133	Gene names	EGF
Domain Architecture
Description	Pro-epidermal growth factor precursor (EGF) [Contains: Epidermal growth factor (Urogastrone)].

EGF_MOUSE
θ value	θ > 10 (rank : 135)	NC score	0.156430 (rank : 60)
Query Neighborhood Hits	96	Target Neighborhood Hits	358	Shared Neighborhood Hits	31
SwissProt Accessions	P01132, Q6P9J2	Gene names	Egf
Domain Architecture
Description	Pro-epidermal growth factor precursor (EGF) [Contains: Epidermal growth factor].

ELA2A_HUMAN
θ value	θ > 10 (rank : 136)	NC score	0.051335 (rank : 273)
Query Neighborhood Hits	96	Target Neighborhood Hits	180	Shared Neighborhood Hits	16
SwissProt Accessions	P08217, Q14243	Gene names	ELA2A
Domain Architecture
Description	Elastase-2A precursor (EC 3.4.21.71).

ELA2A_MOUSE
θ value	θ > 10 (rank : 137)	NC score	0.052261 (rank : 261)
Query Neighborhood Hits	96	Target Neighborhood Hits	178	Shared Neighborhood Hits	16
SwissProt Accessions	P05208	Gene names	Ela2a, Ela-2, Ela2
Domain Architecture
Description	Elastase-2A precursor (EC 3.4.21.71) (Elastase-2).

ELA2B_HUMAN
θ value	θ > 10 (rank : 138)	NC score	0.050866 (rank : 276)
Query Neighborhood Hits	96	Target Neighborhood Hits	178	Shared Neighborhood Hits	16
SwissProt Accessions	P08218	Gene names	ELA2B
Domain Architecture
Description	Elastase-2B precursor (EC 3.4.21.71).

ELA3B_HUMAN
θ value	θ > 10 (rank : 139)	NC score	0.050199 (rank : 282)
Query Neighborhood Hits	96	Target Neighborhood Hits	175	Shared Neighborhood Hits	16
SwissProt Accessions	P08861, P11423, Q5VU28, Q5VU29, Q5VU30	Gene names	ELA3B
Domain Architecture
Description	Elastase-3B precursor (EC 3.4.21.70) (Elastase IIIB) (Protease E).

FA10_HUMAN
θ value	θ > 10 (rank : 140)	NC score	0.069361 (rank : 144)
Query Neighborhood Hits	96	Target Neighborhood Hits	431	Shared Neighborhood Hits	44
SwissProt Accessions	P00742, Q14340	Gene names	F10
Domain Architecture
Description	Coagulation factor X precursor (EC 3.4.21.6) (Stuart factor) (Stuart- Prower factor) [Contains: Factor X light chain; Factor X heavy chain; Activated factor Xa heavy chain].

FA10_MOUSE
θ value	θ > 10 (rank : 141)	NC score	0.070592 (rank : 140)
Query Neighborhood Hits	96	Target Neighborhood Hits	435	Shared Neighborhood Hits	44
SwissProt Accessions	O88947, O54740, Q99L32	Gene names	F10
Domain Architecture
Description	Coagulation factor X precursor (EC 3.4.21.6) (Stuart factor) [Contains: Factor X light chain; Factor X heavy chain; Activated factor Xa heavy chain].

FA11_HUMAN
θ value	θ > 10 (rank : 142)	NC score	0.055076 (rank : 234)
Query Neighborhood Hits	96	Target Neighborhood Hits	178	Shared Neighborhood Hits	16
SwissProt Accessions	P03951, Q9Y495	Gene names	F11
Domain Architecture
Description	Coagulation factor XI precursor (EC 3.4.21.27) (Plasma thromboplastin antecedent) (PTA) (FXI) [Contains: Coagulation factor XIa heavy chain; Coagulation factor XIa light chain].

FA11_MOUSE
θ value	θ > 10 (rank : 143)	NC score	0.055455 (rank : 228)
Query Neighborhood Hits	96	Target Neighborhood Hits	180	Shared Neighborhood Hits	16
SwissProt Accessions	Q91Y47	Gene names	F11
Domain Architecture
Description	Coagulation factor XI precursor (EC 3.4.21.27) (Plasma thromboplastin antecedent) (PTA) (FXI) [Contains: Coagulation factor XIa heavy chain; Coagulation factor XIa light chain].

FA12_HUMAN
θ value	θ > 10 (rank : 144)	NC score	0.060289 (rank : 190)
Query Neighborhood Hits	96	Target Neighborhood Hits	425	Shared Neighborhood Hits	28
SwissProt Accessions	P00748, P78339	Gene names	F12
Domain Architecture
Description	Coagulation factor XII precursor (EC 3.4.21.38) (Hageman factor) (HAF) [Contains: Coagulation factor XIIa heavy chain; Beta-factor XIIa part 1; Beta-factor XIIa part 2; Coagulation factor XIIa light chain].

FA7_HUMAN
θ value	θ > 10 (rank : 145)	NC score	0.065650 (rank : 163)
Query Neighborhood Hits	96	Target Neighborhood Hits	404	Shared Neighborhood Hits	41
SwissProt Accessions	P08709, Q14339, Q5JVF2	Gene names	F7
Domain Architecture
Description	Coagulation factor VII precursor (EC 3.4.21.21) (Serum prothrombin conversion accelerator) (SPCA) (Proconvertin) (Eptacog alfa) [Contains: Factor VII light chain; Factor VII heavy chain].

FA7_MOUSE
θ value	θ > 10 (rank : 146)	NC score	0.065467 (rank : 166)
Query Neighborhood Hits	96	Target Neighborhood Hits	374	Shared Neighborhood Hits	37
SwissProt Accessions	P70375, Q61109	Gene names	F7, Cf7
Domain Architecture
Description	Coagulation factor VII precursor (EC 3.4.21.21) (Serum prothrombin conversion accelerator) [Contains: Factor VII light chain; Factor VII heavy chain].

FA9_HUMAN
θ value	θ > 10 (rank : 147)	NC score	0.070822 (rank : 137)
Query Neighborhood Hits	96	Target Neighborhood Hits	421	Shared Neighborhood Hits	45
SwissProt Accessions	P00740	Gene names	F9
Domain Architecture
Description	Coagulation factor IX precursor (EC 3.4.21.22) (Christmas factor) (Plasma thromboplastin component) (PTC) [Contains: Coagulation factor IXa light chain; Coagulation factor IXa heavy chain].

FBLN1_HUMAN
θ value	θ > 10 (rank : 148)	NC score	0.072139 (rank : 135)
Query Neighborhood Hits	96	Target Neighborhood Hits	324	Shared Neighborhood Hits	33
SwissProt Accessions	P23142, P23143, P23144, P37888, Q5TIC4, Q8TBH8, Q9HBQ5, Q9UC21, Q9UGR4, Q9UH41	Gene names	FBLN1
Domain Architecture
Description	Fibulin-1 precursor.

FBLN1_MOUSE
θ value	θ > 10 (rank : 149)	NC score	0.075567 (rank : 116)
Query Neighborhood Hits	96	Target Neighborhood Hits	329	Shared Neighborhood Hits	33
SwissProt Accessions	Q08879, Q08878, Q8C3B1, Q91ZC9, Q922K8	Gene names	Fbln1
Domain Architecture
Description	Fibulin-1 precursor (Basement-membrane protein 90) (BM-90).

FBLN2_HUMAN
θ value	θ > 10 (rank : 150)	NC score	0.073317 (rank : 128)
Query Neighborhood Hits	96	Target Neighborhood Hits	392	Shared Neighborhood Hits	34
SwissProt Accessions	P98095	Gene names	FBLN2
Domain Architecture
Description	Fibulin-2 precursor.

FBLN2_MOUSE
θ value	θ > 10 (rank : 151)	NC score	0.073182 (rank : 130)
Query Neighborhood Hits	96	Target Neighborhood Hits	505	Shared Neighborhood Hits	35
SwissProt Accessions	P37889, Q9WUI2	Gene names	Fbln2
Domain Architecture
Description	Fibulin-2 precursor.

FBLN3_HUMAN
θ value	θ > 10 (rank : 152)	NC score	0.063893 (rank : 174)
Query Neighborhood Hits	96	Target Neighborhood Hits	293	Shared Neighborhood Hits	30
SwissProt Accessions	Q12805	Gene names	EFEMP1, FBLN3, FBNL
Domain Architecture
Description	EGF-containing fibulin-like extracellular matrix protein 1 precursor (Fibulin-3) (FIBL-3) (Fibrillin-like protein) (Extracellular protein S1-5).

FBLN3_MOUSE
θ value	θ > 10 (rank : 153)	NC score	0.061318 (rank : 184)
Query Neighborhood Hits	96	Target Neighborhood Hits	279	Shared Neighborhood Hits	28
SwissProt Accessions	Q8BPB5, Q6Y3N6	Gene names	Efemp1, Fbln3
Domain Architecture	No domain graphic available
Description	EGF-containing fibulin-like extracellular matrix protein 1 precursor (Fibulin-3) (FIBL-3).

FBLN4_HUMAN
θ value	θ > 10 (rank : 154)	NC score	0.064276 (rank : 171)
Query Neighborhood Hits	96	Target Neighborhood Hits	278	Shared Neighborhood Hits	29
SwissProt Accessions	O95967, O75967	Gene names	EFEMP2, FBLN4
Domain Architecture
Description	EGF-containing fibulin-like extracellular matrix protein 2 precursor (Fibulin-4) (FIBL-4) (UPH1 protein).

FBLN4_MOUSE
θ value	θ > 10 (rank : 155)	NC score	0.064218 (rank : 172)
Query Neighborhood Hits	96	Target Neighborhood Hits	270	Shared Neighborhood Hits	28
SwissProt Accessions	Q9WVJ9	Gene names	Efemp2, Fbln4, Mbp1
Domain Architecture
Description	EGF-containing fibulin-like extracellular matrix protein 2 precursor (Fibulin-4) (FIBL-4) (Mutant p53-binding protein 1).

FBLN5_HUMAN
θ value	θ > 10 (rank : 156)	NC score	0.067905 (rank : 151)
Query Neighborhood Hits	96	Target Neighborhood Hits	329	Shared Neighborhood Hits	32
SwissProt Accessions	Q9UBX5, O75966, Q6UWA3	Gene names	FBLN5, DANCE
Domain Architecture
Description	Fibulin-5 precursor (FIBL-5) (Developmental arteries and neural crest EGF-like protein) (Dance) (Urine p50 protein) (UP50).

FBLN5_MOUSE
θ value	θ > 10 (rank : 157)	NC score	0.066982 (rank : 157)
Query Neighborhood Hits	96	Target Neighborhood Hits	317	Shared Neighborhood Hits	30
SwissProt Accessions	Q9WVH9, Q541Z7	Gene names	Fbln5, Dance
Domain Architecture
Description	Fibulin-5 precursor (FIBL-5) (Developmental arteries and neural crest EGF-like protein) (Dance).

FBN2_HUMAN
θ value	θ > 10 (rank : 158)	NC score	0.077346 (rank : 111)
Query Neighborhood Hits	96	Target Neighborhood Hits	560	Shared Neighborhood Hits	38
SwissProt Accessions	P35556	Gene names	FBN2
Domain Architecture
Description	Fibrillin-2 precursor.

FBN2_MOUSE
θ value	θ > 10 (rank : 159)	NC score	0.077345 (rank : 112)
Query Neighborhood Hits	96	Target Neighborhood Hits	549	Shared Neighborhood Hits	39
SwissProt Accessions	Q61555, Q63957	Gene names	Fbn2, Fbn-2
Domain Architecture
Description	Fibrillin-2 precursor.

FBN3_HUMAN
θ value	θ > 10 (rank : 160)	NC score	0.077261 (rank : 113)
Query Neighborhood Hits	96	Target Neighborhood Hits	543	Shared Neighborhood Hits	35
SwissProt Accessions	Q75N90, Q75N91, Q75N92, Q75N93, Q86SJ5, Q96JP8	Gene names	FBN3, KIAA1776
Domain Architecture	No domain graphic available
Description	Fibrillin-3 precursor.

GAS6_HUMAN
θ value	θ > 10 (rank : 161)	NC score	0.074674 (rank : 121)
Query Neighborhood Hits	96	Target Neighborhood Hits	348	Shared Neighborhood Hits	34
SwissProt Accessions	Q14393, Q7Z7N3	Gene names	GAS6
Domain Architecture
Description	Growth-arrest-specific protein 6 precursor (GAS-6).

GAS6_MOUSE
θ value	θ > 10 (rank : 162)	NC score	0.075277 (rank : 118)
Query Neighborhood Hits	96	Target Neighborhood Hits	343	Shared Neighborhood Hits	29
SwissProt Accessions	Q61592, Q99K57	Gene names	Gas6
Domain Architecture
Description	Growth-arrest-specific protein 6 precursor (GAS-6).

GLU2B_HUMAN
θ value	θ > 10 (rank : 163)	NC score	0.112034 (rank : 88)
Query Neighborhood Hits	96	Target Neighborhood Hits	377	Shared Neighborhood Hits	40
SwissProt Accessions	P14314, Q96BU9, Q96D06, Q9P0W9	Gene names	PRKCSH, G19P1
Domain Architecture	No domain graphic available
Description	Glucosidase 2 subunit beta precursor (Glucosidase II subunit beta) (Protein kinase C substrate, 60.1 kDa protein, heavy chain) (PKCSH) (80K-H protein).

GLU2B_MOUSE
θ value	θ > 10 (rank : 164)	NC score	0.104048 (rank : 91)
Query Neighborhood Hits	96	Target Neighborhood Hits	357	Shared Neighborhood Hits	39
SwissProt Accessions	O08795, Q921X2	Gene names	Prkcsh
Domain Architecture	No domain graphic available
Description	Glucosidase 2 subunit beta precursor (Glucosidase II subunit beta) (Protein kinase C substrate, 60.1 kDa protein, heavy chain) (PKCSH) (80K-H protein).

GRN_HUMAN
θ value	θ > 10 (rank : 165)	NC score	0.094302 (rank : 94)
Query Neighborhood Hits	96	Target Neighborhood Hits	268	Shared Neighborhood Hits	34
SwissProt Accessions	P28799, P23781, P23782, P23783, P23784, Q9BWE7, Q9UCH0	Gene names	GRN
Domain Architecture
Description	Granulins precursor (Proepithelin) (PEPI) [Contains: Acrogranin; Paragranulin; Granulin-1 (Granulin G); Granulin-2 (Granulin F); Granulin-3 (Granulin B); Granulin-4 (Granulin A); Granulin-5 (Granulin C); Granulin-6 (Granulin D); Granulin-7 (Granulin E)].

GRN_MOUSE
θ value	θ > 10 (rank : 166)	NC score	0.072496 (rank : 133)
Query Neighborhood Hits	96	Target Neighborhood Hits	248	Shared Neighborhood Hits	28
SwissProt Accessions	P28798	Gene names	Grn
Domain Architecture
Description	Granulins precursor (Proepithelin) (PEPI) (PC cell-derived growth factor) (PCDGF) [Contains: Acrogranin; Granulin-1; Granulin-2; Granulin-3; Granulin-4; Granulin-5; Granulin-6; Granulin-7].

HABP2_HUMAN
θ value	θ > 10 (rank : 167)	NC score	0.057978 (rank : 206)
Query Neighborhood Hits	96	Target Neighborhood Hits	431	Shared Neighborhood Hits	32
SwissProt Accessions	Q14520, O00663	Gene names	HABP2, HGFAL, PHBP
Domain Architecture	No domain graphic available
Description	Hyaluronan-binding protein 2 precursor (EC 3.4.21.-) (Plasma hyaluronan-binding protein) (Hepatocyte growth factor activator-like protein) (Factor VII-activating protease) (Factor seven-activating protease) (FSAP) [Contains: Hyaluronan-binding protein 2 50 kDa heavy chain; Hyaluronan-binding protein 2 50 kDa heavy chain alternate form; Hyaluronan-binding protein 2 27 kDa light chain; Hyaluronan-binding protein 2 27 kDa light chain alternate form].

HABP2_MOUSE
θ value	θ > 10 (rank : 168)	NC score	0.060530 (rank : 186)
Query Neighborhood Hits	96	Target Neighborhood Hits	445	Shared Neighborhood Hits	39
SwissProt Accessions	Q8K0D2	Gene names	Habp2, Phbp
Domain Architecture	No domain graphic available
Description	Hyaluronan-binding protein 2 precursor (EC 3.4.21.-) (Plasma hyaluronan-binding protein) [Contains: Hyaluronan-binding protein 2 50 kDa heavy chain; Hyaluronan-binding protein 2 50 kDa heavy chain alternate form; Hyaluronan-binding protein 2 27 kDa light chain; Hyaluronan-binding protein 2 27 kDa light chain alternate form].

HEPS_HUMAN
θ value	θ > 10 (rank : 169)	NC score	0.056349 (rank : 220)
Query Neighborhood Hits	96	Target Neighborhood Hits	178	Shared Neighborhood Hits	16
SwissProt Accessions	P05981	Gene names	HPN, TMPRSS1
Domain Architecture
Description	Serine protease hepsin (EC 3.4.21.-) (Transmembrane protease, serine 1) [Contains: Serine protease hepsin non-catalytic chain; Serine protease hepsin catalytic chain].

HEPS_MOUSE
θ value	θ > 10 (rank : 170)	NC score	0.056600 (rank : 217)
Query Neighborhood Hits	96	Target Neighborhood Hits	178	Shared Neighborhood Hits	16
SwissProt Accessions	O35453, Q9CW97	Gene names	Hpn
Domain Architecture
Description	Serine protease hepsin (EC 3.4.21.-) [Contains: Serine protease hepsin non-catalytic chain; Serine protease hepsin catalytic chain].

HGFA_HUMAN
θ value	θ > 10 (rank : 171)	NC score	0.059507 (rank : 196)
Query Neighborhood Hits	96	Target Neighborhood Hits	436	Shared Neighborhood Hits	31
SwissProt Accessions	Q04756, Q14726	Gene names	HGFAC
Domain Architecture
Description	Hepatocyte growth factor activator precursor (EC 3.4.21.-) (HGF activator) (HGFA) [Contains: Hepatocyte growth factor activator short chain; Hepatocyte growth factor activator long chain].

HGFA_MOUSE
θ value	θ > 10 (rank : 172)	NC score	0.059104 (rank : 198)
Query Neighborhood Hits	96	Target Neighborhood Hits	419	Shared Neighborhood Hits	31
SwissProt Accessions	Q9R098, Q9JKV4	Gene names	Hgfac
Domain Architecture
Description	Hepatocyte growth factor activator precursor (EC 3.4.21.-) (HGF activator) (HGFA) [Contains: Hepatocyte growth factor activator short chain; Hepatocyte growth factor activator long chain].

HPT_MOUSE
θ value	θ > 10 (rank : 173)	NC score	0.051569 (rank : 267)
Query Neighborhood Hits	96	Target Neighborhood Hits	178	Shared Neighborhood Hits	16
SwissProt Accessions	Q61646	Gene names	Hp
Domain Architecture
Description	Haptoglobin precursor [Contains: Haptoglobin alpha chain; Haptoglobin beta chain].

JAG1_HUMAN
θ value	θ > 10 (rank : 174)	NC score	0.056563 (rank : 218)
Query Neighborhood Hits	96	Target Neighborhood Hits	514	Shared Neighborhood Hits	38
SwissProt Accessions	P78504, O14902, O15122, Q15816	Gene names	JAG1, JAGL1
Domain Architecture
Description	Jagged-1 precursor (Jagged1) (hJ1) (CD339 antigen).

JAG1_MOUSE
θ value	θ > 10 (rank : 175)	NC score	0.057660 (rank : 210)
Query Neighborhood Hits	96	Target Neighborhood Hits	518	Shared Neighborhood Hits	37
SwissProt Accessions	Q9QXX0	Gene names	Jag1
Domain Architecture
Description	Jagged-1 precursor (Jagged1) (CD339 antigen).

JAG2_HUMAN
θ value	θ > 10 (rank : 176)	NC score	0.060245 (rank : 192)
Query Neighborhood Hits	96	Target Neighborhood Hits	491	Shared Neighborhood Hits	40
SwissProt Accessions	Q9Y219, Q9UE17, Q9UE99, Q9UNK8, Q9Y6P9, Q9Y6Q0	Gene names	JAG2
Domain Architecture
Description	Jagged-2 precursor (Jagged2) (HJ2).

JAG2_MOUSE
θ value	θ > 10 (rank : 177)	NC score	0.060432 (rank : 188)
Query Neighborhood Hits	96	Target Neighborhood Hits	504	Shared Neighborhood Hits	40
SwissProt Accessions	Q9QYE5, O55139, O70219	Gene names	Jag2
Domain Architecture
Description	Jagged-2 precursor (Jagged2).

KLKB1_HUMAN
θ value	θ > 10 (rank : 178)	NC score	0.055177 (rank : 233)
Query Neighborhood Hits	96	Target Neighborhood Hits	183	Shared Neighborhood Hits	16
SwissProt Accessions	P03952	Gene names	KLKB1, KLK3
Domain Architecture
Description	Plasma kallikrein precursor (EC 3.4.21.34) (Plasma prekallikrein) (Kininogenin) (Fletcher factor) [Contains: Plasma kallikrein heavy chain; Plasma kallikrein light chain].

KLKB1_MOUSE
θ value	θ > 10 (rank : 179)	NC score	0.056182 (rank : 222)
Query Neighborhood Hits	96	Target Neighborhood Hits	177	Shared Neighborhood Hits	16
SwissProt Accessions	P26262	Gene names	Klkb1, Klk3, Pk
Domain Architecture
Description	Plasma kallikrein precursor (EC 3.4.21.34) (Plasma prekallikrein) (Kininogenin) (Fletcher factor) [Contains: Plasma kallikrein heavy chain; Plasma kallikrein light chain].

KR104_HUMAN
θ value	θ > 10 (rank : 180)	NC score	0.055249 (rank : 230)
Query Neighborhood Hits	96	Target Neighborhood Hits	313	Shared Neighborhood Hits	23
SwissProt Accessions	P60372	Gene names	KRTAP10-4, KAP10.4, KAP18-4, KRTAP10.4, KRTAP18-4, KRTAP18.4
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 10-4 (Keratin-associated protein 10.4) (High sulfur keratin-associated protein 10.4) (Keratin-associated protein 18-4) (Keratin-associated protein 18.4).

KR106_HUMAN
θ value	θ > 10 (rank : 181)	NC score	0.058223 (rank : 205)
Query Neighborhood Hits	96	Target Neighborhood Hits	347	Shared Neighborhood Hits	30
SwissProt Accessions	P60371	Gene names	KRTAP10-6, KAP10.6, KAP18-6, KRTAP10.6, KRTAP18-6, KRTAP18.6
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 10-6 (Keratin-associated protein 10.6) (High sulfur keratin-associated protein 10.6) (Keratin-associated protein 18-6) (Keratin-associated protein 18.6).

KR107_HUMAN
θ value	θ > 10 (rank : 182)	NC score	0.062722 (rank : 180)
Query Neighborhood Hits	96	Target Neighborhood Hits	330	Shared Neighborhood Hits	28
SwissProt Accessions	P60409, Q70LJ2	Gene names	KRTAP10-7, KAP10.7, KAP18-7, KRTAP10.7, KRTAP18-7, KRTAP18.7
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 10-7 (Keratin-associated protein 10.7) (High sulfur keratin-associated protein 10.7) (Keratin-associated protein 18-7) (Keratin-associated protein 18.7).

KRA53_HUMAN
θ value	θ > 10 (rank : 183)	NC score	0.051761 (rank : 263)
Query Neighborhood Hits	96	Target Neighborhood Hits	331	Shared Neighborhood Hits	22
SwissProt Accessions	Q6L8H2, Q6PL44, Q701N3	Gene names	KRTAP5-3, KAP5-9, KAP5.3, KRTAP5-9, KRTAP5.3, KRTAP5.9
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 5-3 (Keratin-associated protein 5.3) (Ultrahigh sulfur keratin-associated protein 5.3) (Keratin-associated protein 5-9) (Keratin-associated protein 5.9) (UHS KerB-like).

KRA59_HUMAN
θ value	θ > 10 (rank : 184)	NC score	0.050643 (rank : 278)
Query Neighborhood Hits	96	Target Neighborhood Hits	310	Shared Neighborhood Hits	20
SwissProt Accessions	P26371, Q14564	Gene names	KRTAP5-9, KAP5.9, KRN1, KRTAP5.9, UHSK1
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 5-9 (Keratin-associated protein 5.9) (Ultrahigh sulfur keratin-associated protein 5.9) (Keratin, cuticle, ultrahigh sulfur 1) (Keratin, ultra high-sulfur matrix protein A) (UHS keratin A) (UHS KerA).

LCE3B_HUMAN
θ value	θ > 10 (rank : 185)	NC score	0.057456 (rank : 212)
Query Neighborhood Hits	96	Target Neighborhood Hits	47	Shared Neighborhood Hits	10
SwissProt Accessions	Q5TA77	Gene names	LCE3B, LEP14
Domain Architecture	No domain graphic available
Description	Late cornified envelope protein 3B (Late envelope protein 14).

LTB1L_HUMAN
θ value	θ > 10 (rank : 186)	NC score	0.074620 (rank : 122)
Query Neighborhood Hits	96	Target Neighborhood Hits	553	Shared Neighborhood Hits	40
SwissProt Accessions	Q14766	Gene names	LTBP1
Domain Architecture
Description	Latent-transforming growth factor beta-binding protein, isoform 1L precursor (LTBP-1) (Transforming growth factor beta-1-binding protein 1) (TGF-beta1-BP-1).

LTB1L_MOUSE
θ value	θ > 10 (rank : 187)	NC score	0.069965 (rank : 141)
Query Neighborhood Hits	96	Target Neighborhood Hits	514	Shared Neighborhood Hits	39
SwissProt Accessions	Q8CG19, O88349, Q8BNW7, Q8C7F5, Q8CIR0	Gene names	Ltbp1
Domain Architecture
Description	Latent-transforming growth factor beta-binding protein, isoform 1L precursor (LTBP-1) (Transforming growth factor beta-1-binding protein 1) (TGF-beta1-BP-1).

LTB1S_HUMAN
θ value	θ > 10 (rank : 188)	NC score	0.073955 (rank : 124)
Query Neighborhood Hits	96	Target Neighborhood Hits	502	Shared Neighborhood Hits	37
SwissProt Accessions	P22064, Q8TD95	Gene names	LTBP1
Domain Architecture
Description	Latent-transforming growth factor beta-binding protein, isoform 1S precursor (LTBP-1) (Transforming growth factor beta-1-binding protein 1) (TGF-beta1-BP-1).

LTB1S_MOUSE
θ value	θ > 10 (rank : 189)	NC score	0.069852 (rank : 143)
Query Neighborhood Hits	96	Target Neighborhood Hits	479	Shared Neighborhood Hits	36
SwissProt Accessions	Q8CG18, Q8BNW7, Q8C7F5, Q8CIR0	Gene names	Ltbp1
Domain Architecture
Description	Latent-transforming growth factor beta-binding protein, isoform 1S precursor (LTBP-1) (Transforming growth factor beta-1-binding protein 1) (TGF-beta1-BP-1).

LTBP2_HUMAN
θ value	θ > 10 (rank : 190)	NC score	0.070706 (rank : 138)
Query Neighborhood Hits	96	Target Neighborhood Hits	552	Shared Neighborhood Hits	36
SwissProt Accessions	Q14767, Q99907, Q9NS51	Gene names	LTBP2
Domain Architecture
Description	Latent-transforming growth factor beta-binding protein 2 precursor (LTBP-2).

LTBP2_MOUSE
θ value	θ > 10 (rank : 191)	NC score	0.063673 (rank : 176)
Query Neighborhood Hits	96	Target Neighborhood Hits	617	Shared Neighborhood Hits	35
SwissProt Accessions	O08999, Q8C6W9	Gene names	Ltbp2
Domain Architecture
Description	Latent-transforming growth factor beta-binding protein 2 precursor (LTBP-2).

LTBP3_HUMAN
θ value	θ > 10 (rank : 192)	NC score	0.063181 (rank : 179)
Query Neighborhood Hits	96	Target Neighborhood Hits	502	Shared Neighborhood Hits	34
SwissProt Accessions	Q9NS15, O15107, Q96HB9, Q9H7K2, Q9UFN4	Gene names	LTBP3
Domain Architecture
Description	Latent-transforming growth factor beta-binding protein 3 precursor (LTBP-3).

LTBP3_MOUSE
θ value	θ > 10 (rank : 193)	NC score	0.063320 (rank : 178)
Query Neighborhood Hits	96	Target Neighborhood Hits	475	Shared Neighborhood Hits	36
SwissProt Accessions	Q61810, Q8BNQ6	Gene names	Ltbp3
Domain Architecture
Description	Latent-transforming growth factor beta-binding protein 3 precursor (LTBP-3).

LTBP4_MOUSE
θ value	θ > 10 (rank : 194)	NC score	0.066782 (rank : 158)
Query Neighborhood Hits	96	Target Neighborhood Hits	607	Shared Neighborhood Hits	38
SwissProt Accessions	Q8K4G1, Q8K4G0	Gene names	Ltbp4
Domain Architecture
Description	Latent-transforming growth factor beta-binding protein 4 precursor (LTBP-4).

MASP1_HUMAN
θ value	θ > 10 (rank : 195)	NC score	0.069957 (rank : 142)
Query Neighborhood Hits	96	Target Neighborhood Hits	369	Shared Neighborhood Hits	40
SwissProt Accessions	P48740, O95570, Q9UF09	Gene names	MASP1, CRARF, CRARF1, PRSS5
Domain Architecture
Description	Complement-activating component of Ra-reactive factor precursor (EC 3.4.21.-) (Ra-reactive factor serine protease p100) (RaRF) (Mannan-binding lectin serine protease 1) (Mannose-binding protein- associated serine protease) (MASP-1) [Contains: Complement-activating component of Ra-reactive factor heavy chain; Complement-activating component of Ra-reactive factor light chain].

MASP1_MOUSE
θ value	θ > 10 (rank : 196)	NC score	0.068227 (rank : 150)
Query Neighborhood Hits	96	Target Neighborhood Hits	364	Shared Neighborhood Hits	39
SwissProt Accessions	P98064	Gene names	Masp1, Crarf
Domain Architecture
Description	Complement-activating component of Ra-reactive factor precursor (EC 3.4.21.-) (Ra-reactive factor serine protease p100) (RaRF) (Mannan-binding lectin serine protease 1) [Contains: Complement- activating component of Ra-reactive factor heavy chain; Complement- activating component of Ra-reactive factor light chain].

MASP2_HUMAN
θ value	θ > 10 (rank : 197)	NC score	0.069257 (rank : 145)
Query Neighborhood Hits	96	Target Neighborhood Hits	364	Shared Neighborhood Hits	40
SwissProt Accessions	O00187, O75754, Q5TEQ5, Q5TER0, Q96QG4, Q9BZH0, Q9H498, Q9H499, Q9UBP3, Q9ULC7, Q9UMV3, Q9Y270	Gene names	MASP2
Domain Architecture
Description	Mannan-binding lectin serine protease 2 precursor (EC 3.4.21.104) (Mannose-binding protein-associated serine protease 2) (MASP-2) (MBL- associated serine protease 2) [Contains: Mannan-binding lectin serine protease 2 A chain; Mannan-binding lectin serine protease 2 B chain].

MASP2_MOUSE
θ value	θ > 10 (rank : 198)	NC score	0.067130 (rank : 156)
Query Neighborhood Hits	96	Target Neighborhood Hits	382	Shared Neighborhood Hits	39
SwissProt Accessions	Q91WP0, Q9QXA4, Q9QXD2, Q9QXD5, Q9Z338	Gene names	Masp2
Domain Architecture	No domain graphic available
Description	Mannan-binding lectin serine protease 2 precursor (EC 3.4.21.104) (Mannose-binding protein-associated serine protease 2) (MASP-2) (MBL- associated serine protease 2) [Contains: Mannan-binding lectin serine protease 2 A chain; Mannan-binding lectin serine protease 2 B chain].

MATN1_HUMAN
θ value	θ > 10 (rank : 199)	NC score	0.054052 (rank : 250)
Query Neighborhood Hits	96	Target Neighborhood Hits	191	Shared Neighborhood Hits	21
SwissProt Accessions	P21941	Gene names	MATN1, CMP, CRTM
Domain Architecture
Description	Cartilage matrix protein precursor (Matrilin-1).

MATN1_MOUSE
θ value	θ > 10 (rank : 200)	NC score	0.054424 (rank : 244)
Query Neighborhood Hits	96	Target Neighborhood Hits	186	Shared Neighborhood Hits	20
SwissProt Accessions	P51942	Gene names	Matn1, Cmp, Crtm
Domain Architecture
Description	Cartilage matrix protein precursor (Matrilin-1).

MATN2_HUMAN
θ value	θ > 10 (rank : 201)	NC score	0.079570 (rank : 107)
Query Neighborhood Hits	96	Target Neighborhood Hits	365	Shared Neighborhood Hits	33
SwissProt Accessions	O00339, Q6UWA5, Q7Z5X1, Q8NDE6, Q96FT5, Q9NSZ1	Gene names	MATN2
Domain Architecture
Description	Matrilin-2 precursor.

MATN2_MOUSE
θ value	θ > 10 (rank : 202)	NC score	0.073336 (rank : 127)
Query Neighborhood Hits	96	Target Neighborhood Hits	356	Shared Neighborhood Hits	31
SwissProt Accessions	O08746	Gene names	Matn2
Domain Architecture
Description	Matrilin-2 precursor.

MATN3_HUMAN
θ value	θ > 10 (rank : 203)	NC score	0.075112 (rank : 120)
Query Neighborhood Hits	96	Target Neighborhood Hits	268	Shared Neighborhood Hits	26
SwissProt Accessions	O15232	Gene names	MATN3
Domain Architecture
Description	Matrilin-3 precursor.

MATN3_MOUSE
θ value	θ > 10 (rank : 204)	NC score	0.073716 (rank : 126)
Query Neighborhood Hits	96	Target Neighborhood Hits	261	Shared Neighborhood Hits	25
SwissProt Accessions	O35701, Q9JHM0	Gene names	Matn3
Domain Architecture
Description	Matrilin-3 precursor.

MATN4_HUMAN
θ value	θ > 10 (rank : 205)	NC score	0.075225 (rank : 119)
Query Neighborhood Hits	96	Target Neighborhood Hits	287	Shared Neighborhood Hits	30
SwissProt Accessions	O95460, Q5QPU2, Q5QPU3, Q5QPU4, Q8N2M5, Q8N2M7, Q9H1F8, Q9H1F9	Gene names	MATN4
Domain Architecture
Description	Matrilin-4 precursor.

MATN4_MOUSE
θ value	θ > 10 (rank : 206)	NC score	0.075988 (rank : 114)
Query Neighborhood Hits	96	Target Neighborhood Hits	277	Shared Neighborhood Hits	31
SwissProt Accessions	O89029, O89030, Q9QWS3	Gene names	Matn4
Domain Architecture
Description	Matrilin-4 precursor (MAT-4).

MCPT6_MOUSE
θ value	θ > 10 (rank : 207)	NC score	0.052722 (rank : 257)
Query Neighborhood Hits	96	Target Neighborhood Hits	175	Shared Neighborhood Hits	16
SwissProt Accessions	P21845, Q61962	Gene names	Mcpt6
Domain Architecture
Description	Mast cell protease 6 precursor (EC 3.4.21.59) (MMCP-6) (Tryptase).

MEGF6_HUMAN
θ value	θ > 10 (rank : 208)	NC score	0.066652 (rank : 159)
Query Neighborhood Hits	96	Target Neighborhood Hits	671	Shared Neighborhood Hits	40
SwissProt Accessions	O75095, Q5VV39	Gene names	MEGF6, EGFL3, KIAA0815
Domain Architecture	No domain graphic available
Description	Multiple epidermal growth factor-like domains 6 precursor (EGF-like domain-containing protein 3) (Multiple EGF-like domain protein 3).

NELL1_HUMAN
θ value	θ > 10 (rank : 209)	NC score	0.059154 (rank : 197)
Query Neighborhood Hits	96	Target Neighborhood Hits	451	Shared Neighborhood Hits	31
SwissProt Accessions	Q92832, Q9Y472	Gene names	NELL1, NRP1
Domain Architecture
Description	Protein kinase C-binding protein NELL1 precursor (NEL-like protein 1) (Nel-related protein 1).

NELL2_HUMAN
θ value	θ > 10 (rank : 210)	NC score	0.062318 (rank : 181)
Query Neighborhood Hits	96	Target Neighborhood Hits	449	Shared Neighborhood Hits	34
SwissProt Accessions	Q99435	Gene names	NELL2, NRP2
Domain Architecture
Description	Protein kinase C-binding protein NELL2 precursor (NEL-like protein 2) (Nel-related protein 2).

NELL2_MOUSE
θ value	θ > 10 (rank : 211)	NC score	0.060259 (rank : 191)
Query Neighborhood Hits	96	Target Neighborhood Hits	436	Shared Neighborhood Hits	31
SwissProt Accessions	Q61220	Gene names	Nell2, Mel91
Domain Architecture
Description	Protein kinase C-binding protein NELL2 precursor (NEL-like protein 2) (MEL91 protein).

NETO1_HUMAN
θ value	θ > 10 (rank : 212)	NC score	0.084363 (rank : 103)
Query Neighborhood Hits	96	Target Neighborhood Hits	110	Shared Neighborhood Hits	49
SwissProt Accessions	Q8TDF5, Q86W85, Q8ND78, Q8TDF4	Gene names	NETO1, BTCL1
Domain Architecture	No domain graphic available
Description	Neuropilin and tolloid-like protein 1 precursor (Brain-specific transmembrane protein containing 2 CUB and 1 LDL-receptor class A domains protein 1).

NETO1_MOUSE
θ value	θ > 10 (rank : 213)	NC score	0.084340 (rank : 104)
Query Neighborhood Hits	96	Target Neighborhood Hits	109	Shared Neighborhood Hits	49
SwissProt Accessions	Q8R4I7, Q80X39, Q8C4S3, Q8CCM2	Gene names	Neto1, Btcl1
Domain Architecture	No domain graphic available
Description	Neuropilin and tolloid-like protein 1 precursor (Brain-specific transmembrane protein containing 2 CUB and 1 LDL-receptor class A domains protein 1).

NETO2_HUMAN
θ value	θ > 10 (rank : 214)	NC score	0.089556 (rank : 96)
Query Neighborhood Hits	96	Target Neighborhood Hits	109	Shared Neighborhood Hits	46
SwissProt Accessions	Q8NC67, Q7Z381, Q8ND51, Q96SP4, Q9NVY8	Gene names	NETO2, BTCL2
Domain Architecture	No domain graphic available
Description	Neuropilin and tolloid-like protein 2 precursor (Brain-specific transmembrane protein containing 2 CUB and 1 LDL-receptor class A domains protein 2).

NETO2_MOUSE
θ value	θ > 10 (rank : 215)	NC score	0.089745 (rank : 95)
Query Neighborhood Hits	96	Target Neighborhood Hits	113	Shared Neighborhood Hits	46
SwissProt Accessions	Q8BNJ6, Q5VM49, Q8C4Q8	Gene names	Neto2, Btcl2
Domain Architecture	No domain graphic available
Description	Neuropilin and tolloid-like protein 2 precursor (Brain-specific transmembrane protein containing 2 CUB and 1 LDL-receptor class A domains protein 2).

NETR_HUMAN
θ value	θ > 10 (rank : 216)	NC score	0.050609 (rank : 279)
Query Neighborhood Hits	96	Target Neighborhood Hits	218	Shared Neighborhood Hits	16
SwissProt Accessions	P56730, Q9UP16	Gene names	PRSS12
Domain Architecture
Description	Neurotrypsin precursor (EC 3.4.21.-) (Motopsin) (Leydin).

NETR_MOUSE
θ value	θ > 10 (rank : 217)	NC score	0.051382 (rank : 271)
Query Neighborhood Hits	96	Target Neighborhood Hits	216	Shared Neighborhood Hits	16
SwissProt Accessions	O08762	Gene names	Prss12, Bssp3
Domain Architecture
Description	Neurotrypsin precursor (EC 3.4.21.-) (Motopsin) (Brain-specific serine protease 3) (BSSP-3).

NID1_HUMAN
θ value	θ > 10 (rank : 218)	NC score	0.134050 (rank : 74)
Query Neighborhood Hits	96	Target Neighborhood Hits	329	Shared Neighborhood Hits	28
SwissProt Accessions	P14543, Q14942, Q59FL2, Q5TAF2, Q5TAF3, Q86XD7	Gene names	NID1, NID
Domain Architecture
Description	Nidogen-1 precursor (Entactin).

NID1_MOUSE
θ value	θ > 10 (rank : 219)	NC score	0.135219 (rank : 72)
Query Neighborhood Hits	96	Target Neighborhood Hits	335	Shared Neighborhood Hits	29
SwissProt Accessions	P10493, Q8BQI3, Q8C3U8, Q8C9P6	Gene names	Nid1, Ent
Domain Architecture
Description	Nidogen-1 precursor (Entactin).

NID2_HUMAN
θ value	θ > 10 (rank : 220)	NC score	0.125641 (rank : 82)
Query Neighborhood Hits	96	Target Neighborhood Hits	456	Shared Neighborhood Hits	28
SwissProt Accessions	Q14112, O43710	Gene names	NID2
Domain Architecture
Description	Nidogen-2 precursor (NID-2) (Osteonidogen).

NID2_MOUSE
θ value	θ > 10 (rank : 221)	NC score	0.127217 (rank : 81)
Query Neighborhood Hits	96	Target Neighborhood Hits	338	Shared Neighborhood Hits	30
SwissProt Accessions	O88322	Gene names	Nid2
Domain Architecture
Description	Nidogen-2 precursor (NID-2) (Entactin-2).

NOTC1_HUMAN
θ value	θ > 10 (rank : 222)	NC score	0.054919 (rank : 236)
Query Neighborhood Hits	96	Target Neighborhood Hits	906	Shared Neighborhood Hits	41
SwissProt Accessions	P46531	Gene names	NOTCH1, TAN1
Domain Architecture
Description	Neurogenic locus notch homolog protein 1 precursor (Notch 1) (hN1) (Translocation-associated notch protein TAN-1) [Contains: Notch 1 extracellular truncation; Notch 1 intracellular domain].

NOTC1_MOUSE
θ value	θ > 10 (rank : 223)	NC score	0.058461 (rank : 203)
Query Neighborhood Hits	96	Target Neighborhood Hits	916	Shared Neighborhood Hits	44
SwissProt Accessions	Q01705, Q06007, Q61905, Q99JC2, Q9QW58, Q9R0X7	Gene names	Notch1, Motch
Domain Architecture
Description	Neurogenic locus notch homolog protein 1 precursor (Notch 1) (Motch A) (mT14) (p300) [Contains: Notch 1 extracellular truncation; Notch 1 intracellular domain].

NOTC2_HUMAN
θ value	θ > 10 (rank : 224)	NC score	0.054079 (rank : 249)
Query Neighborhood Hits	96	Target Neighborhood Hits	1113	Shared Neighborhood Hits	44
SwissProt Accessions	Q04721, Q99734, Q9H240	Gene names	NOTCH2
Domain Architecture
Description	Neurogenic locus notch homolog protein 2 precursor (Notch 2) (hN2) [Contains: Notch 2 extracellular truncation; Notch 2 intracellular domain].

NOTC2_MOUSE
θ value	θ > 10 (rank : 225)	NC score	0.054396 (rank : 245)
Query Neighborhood Hits	96	Target Neighborhood Hits	1069	Shared Neighborhood Hits	46
SwissProt Accessions	O35516, Q06008, Q60941	Gene names	Notch2
Domain Architecture
Description	Neurogenic locus notch homolog protein 2 precursor (Notch 2) (Motch B) [Contains: Notch 2 extracellular truncation; Notch 2 intracellular domain].

NOTC4_HUMAN
θ value	θ > 10 (rank : 226)	NC score	0.052539 (rank : 260)
Query Neighborhood Hits	96	Target Neighborhood Hits	905	Shared Neighborhood Hits	46
SwissProt Accessions	Q99466, O00306, Q99458, Q99940, Q9H3S8, Q9UII9, Q9UIJ0	Gene names	NOTCH4
Domain Architecture
Description	Neurogenic locus notch homolog protein 4 precursor (Notch 4) (hNotch4) [Contains: Notch 4 extracellular truncation; Notch 4 intracellular domain].

POLS2_HUMAN
θ value	θ > 10 (rank : 227)	NC score	0.058393 (rank : 204)
Query Neighborhood Hits	96	Target Neighborhood Hits	192	Shared Neighborhood Hits	18
SwissProt Accessions	Q5K4E3, Q8NBY4	Gene names	PRSS36
Domain Architecture	No domain graphic available
Description	Polyserase-2 precursor (EC 3.4.21.-) (Polyserine protease 2) (Protease serine 36).

POLS2_MOUSE
θ value	θ > 10 (rank : 228)	NC score	0.057821 (rank : 208)
Query Neighborhood Hits	96	Target Neighborhood Hits	188	Shared Neighborhood Hits	16
SwissProt Accessions	Q5K2P8	Gene names	Prss36
Domain Architecture	No domain graphic available
Description	Polyserase-2 precursor (EC 3.4.21.-) (Polyserine protease 2) (Protease serine 36).

PROC_HUMAN
θ value	θ > 10 (rank : 229)	NC score	0.070693 (rank : 139)
Query Neighborhood Hits	96	Target Neighborhood Hits	406	Shared Neighborhood Hits	39
SwissProt Accessions	P04070, Q15189, Q15190, Q16001	Gene names	PROC
Domain Architecture
Description	Vitamin K-dependent protein C precursor (EC 3.4.21.69) (Autoprothrombin IIA) (Anticoagulant protein C) (Blood coagulation factor XIV) [Contains: Vitamin K-dependent protein C light chain; Vitamin K-dependent protein C heavy chain; Activation peptide].

PROC_MOUSE
θ value	θ > 10 (rank : 230)	NC score	0.073892 (rank : 125)
Query Neighborhood Hits	96	Target Neighborhood Hits	426	Shared Neighborhood Hits	41
SwissProt Accessions	P33587, O35498, Q91WN8, Q99PC6	Gene names	Proc
Domain Architecture
Description	Vitamin K-dependent protein C precursor (EC 3.4.21.69) (Autoprothrombin IIA) (Anticoagulant protein C) (Blood coagulation factor XIV) [Contains: Vitamin K-dependent protein C light chain; Vitamin K-dependent protein C heavy chain; Activation peptide].

PROS_HUMAN
θ value	θ > 10 (rank : 231)	NC score	0.073179 (rank : 131)
Query Neighborhood Hits	96	Target Neighborhood Hits	340	Shared Neighborhood Hits	33
SwissProt Accessions	P07225, Q15518, Q7Z715	Gene names	PROS1, PROS
Domain Architecture
Description	Vitamin K-dependent protein S precursor.

PROS_MOUSE
θ value	θ > 10 (rank : 232)	NC score	0.070981 (rank : 136)
Query Neighborhood Hits	96	Target Neighborhood Hits	330	Shared Neighborhood Hits	29
SwissProt Accessions	Q08761, P43483	Gene names	Pros1, Pros
Domain Architecture
Description	Vitamin K-dependent protein S precursor.

PROZ_HUMAN
θ value	θ > 10 (rank : 233)	NC score	0.078436 (rank : 109)
Query Neighborhood Hits	96	Target Neighborhood Hits	422	Shared Neighborhood Hits	42
SwissProt Accessions	P22891, Q15213	Gene names	PROZ
Domain Architecture
Description	Vitamin K-dependent protein Z precursor.

PROZ_MOUSE
θ value	θ > 10 (rank : 234)	NC score	0.068815 (rank : 147)
Query Neighborhood Hits	96	Target Neighborhood Hits	410	Shared Neighborhood Hits	37
SwissProt Accessions	Q9CQW3	Gene names	Proz
Domain Architecture
Description	Vitamin K-dependent protein Z precursor.

PRS27_HUMAN
θ value	θ > 10 (rank : 235)	NC score	0.055773 (rank : 224)
Query Neighborhood Hits	96	Target Neighborhood Hits	177	Shared Neighborhood Hits	16
SwissProt Accessions	Q9BQR3	Gene names	PRSS27, MPN
Domain Architecture
Description	Protease serine 27 precursor (EC 3.4.21.-) (Marapsin) (Pancreasin) (Channel-activating protease 2) (CAPH2).

PRS27_MOUSE
θ value	θ > 10 (rank : 236)	NC score	0.055473 (rank : 227)
Query Neighborhood Hits	96	Target Neighborhood Hits	175	Shared Neighborhood Hits	16
SwissProt Accessions	Q8BJR6	Gene names	Prss27, Mpn
Domain Architecture	No domain graphic available
Description	Protease serine 27 precursor (EC 3.4.21.-) (Marapsin) (Pancreasin).

PRSS8_HUMAN
θ value	θ > 10 (rank : 237)	NC score	0.054536 (rank : 242)
Query Neighborhood Hits	96	Target Neighborhood Hits	177	Shared Neighborhood Hits	17
SwissProt Accessions	Q16651, Q9UCA3	Gene names	PRSS8
Domain Architecture
Description	Prostasin precursor (EC 3.4.21.-) [Contains: Prostasin light chain; Prostasin heavy chain].

PRSS8_MOUSE
θ value	θ > 10 (rank : 238)	NC score	0.055343 (rank : 229)
Query Neighborhood Hits	96	Target Neighborhood Hits	177	Shared Neighborhood Hits	17
SwissProt Accessions	Q9ESD1	Gene names	Prss8, Cap1
Domain Architecture
Description	Prostasin precursor (EC 3.4.21.-) (Channel-activating protease 1) [Contains: Prostasin light chain; Prostasin heavy chain].

PTGDS_HUMAN
θ value	θ > 10 (rank : 239)	NC score	0.051376 (rank : 272)
Query Neighborhood Hits	96	Target Neighborhood Hits	31	Shared Neighborhood Hits	2
SwissProt Accessions	P41222, Q5SQ10, Q7M4P3, Q9UCC9, Q9UCD9	Gene names	PTGDS, PDS
Domain Architecture
Description	Prostaglandin-H2 D-isomerase precursor (EC 5.3.99.2) (Lipocalin-type prostaglandin-D synthase) (Glutathione-independent PGD synthetase) (Prostaglandin-D2 synthase) (PGD2 synthase) (PGDS2) (PGDS) (Beta-trace protein) (Cerebrin-28).

SCUB3_HUMAN
θ value	θ > 10 (rank : 240)	NC score	0.086907 (rank : 98)
Query Neighborhood Hits	96	Target Neighborhood Hits	428	Shared Neighborhood Hits	41
SwissProt Accessions	Q8IX30, Q5CZB3, Q86UZ9, Q8NAU9	Gene names	SCUBE3, CEGF3
Domain Architecture	No domain graphic available
Description	Signal peptide, CUB and EGF-like domain-containing protein 3 precursor.

SCUB3_MOUSE
θ value	θ > 10 (rank : 241)	NC score	0.086391 (rank : 100)
Query Neighborhood Hits	96	Target Neighborhood Hits	442	Shared Neighborhood Hits	41
SwissProt Accessions	Q66PY1, Q68FG9	Gene names	Scube3
Domain Architecture	No domain graphic available
Description	Signal peptide, CUB and EGF-like domain-containing protein 3 precursor.

SREC2_HUMAN
θ value	θ > 10 (rank : 242)	NC score	0.054169 (rank : 248)
Query Neighborhood Hits	96	Target Neighborhood Hits	645	Shared Neighborhood Hits	34
SwissProt Accessions	Q96GP6, Q8IXF3, Q9BW74	Gene names	SCARF2, SREC2, SREPCR
Domain Architecture	No domain graphic available
Description	Scavenger receptor class F member 2 precursor (Scavenger receptor expressed by endothelial cells 2 protein) (SREC-II) (SRECRP-1).

SREC2_MOUSE
θ value	θ > 10 (rank : 243)	NC score	0.051593 (rank : 266)
Query Neighborhood Hits	96	Target Neighborhood Hits	605	Shared Neighborhood Hits	31
SwissProt Accessions	P59222	Gene names	Scarf2, Srec2
Domain Architecture	No domain graphic available
Description	Scavenger receptor class F member 2 precursor (Scavenger receptor expressed by endothelial cells 2 protein) (SREC-II).

STAB1_HUMAN
θ value	θ > 10 (rank : 244)	NC score	0.053394 (rank : 253)
Query Neighborhood Hits	96	Target Neighborhood Hits	546	Shared Neighborhood Hits	40
SwissProt Accessions	Q9NY15, Q8IUH0, Q8IUH1, Q93072	Gene names	STAB1, FEEL1, KIAA0246
Domain Architecture
Description	Stabilin-1 precursor (FEEL-1 protein) (MS-1 antigen).

STAB1_MOUSE
θ value	θ > 10 (rank : 245)	NC score	0.054051 (rank : 251)
Query Neighborhood Hits	96	Target Neighborhood Hits	566	Shared Neighborhood Hits	35
SwissProt Accessions	Q8R4Y4, Q8K0K6, Q8VC09	Gene names	Stab1, Feel1
Domain Architecture
Description	Stabilin-1 precursor (FEEL-1 protein).

STAB2_MOUSE
θ value	θ > 10 (rank : 246)	NC score	0.058836 (rank : 201)
Query Neighborhood Hits	96	Target Neighborhood Hits	528	Shared Neighborhood Hits	38
SwissProt Accessions	Q8R4U0, Q8BM87	Gene names	Stab2
Domain Architecture	No domain graphic available
Description	Stabilin-2 precursor [Contains: Short form stabilin-2].

SUSD1_HUMAN
θ value	θ > 10 (rank : 247)	NC score	0.055198 (rank : 232)
Query Neighborhood Hits	96	Target Neighborhood Hits	285	Shared Neighborhood Hits	22
SwissProt Accessions	Q6UWL2, Q5T8V7, Q6P9G7, Q8WU83, Q9H6V2, Q9NTA7	Gene names	SUSD1
Domain Architecture	No domain graphic available
Description	Sushi domain-containing protein 1 precursor.

TENA_HUMAN
θ value	θ > 10 (rank : 248)	NC score	0.074041 (rank : 123)
Query Neighborhood Hits	96	Target Neighborhood Hits	631	Shared Neighborhood Hits	42
SwissProt Accessions	P24821, Q14583, Q15567	Gene names	TNC, HXB
Domain Architecture
Description	Tenascin precursor (TN) (Tenascin-C) (TN-C) (Hexabrachion) (Cytotactin) (Neuronectin) (GMEM) (JI) (Myotendinous antigen) (Glioma- associated-extracellular matrix antigen) (GP 150-225).

TENA_MOUSE
θ value	θ > 10 (rank : 249)	NC score	0.073119 (rank : 132)
Query Neighborhood Hits	96	Target Neighborhood Hits	596	Shared Neighborhood Hits	45
SwissProt Accessions	Q80YX1, Q64706, Q80YX2	Gene names	Tnc, Hxb
Domain Architecture	No domain graphic available
Description	Tenascin precursor (TN) (Tenascin-C) (TN-C) (Hexabrachion).

TENX_HUMAN
θ value	θ > 10 (rank : 250)	NC score	0.059880 (rank : 194)
Query Neighborhood Hits	96	Target Neighborhood Hits	789	Shared Neighborhood Hits	42
SwissProt Accessions	P22105, P78530, P78531, Q08424, Q9UMG7	Gene names	TNXB, HXBL, TNX, XB
Domain Architecture
Description	Tenascin-X precursor (TN-X) (Hexabrachion-like protein).

TEST_HUMAN
θ value	θ > 10 (rank : 251)	NC score	0.057441 (rank : 213)
Query Neighborhood Hits	96	Target Neighborhood Hits	172	Shared Neighborhood Hits	16
SwissProt Accessions	Q9Y6M0, Q9NS34, Q9P2V6	Gene names	PRSS21, ESP1, TEST1
Domain Architecture
Description	Testisin precursor (EC 3.4.21.-) (Eosinophil serine protease 1) (ESP- 1).

TEST_MOUSE
θ value	θ > 10 (rank : 252)	NC score	0.055231 (rank : 231)
Query Neighborhood Hits	96	Target Neighborhood Hits	174	Shared Neighborhood Hits	16
SwissProt Accessions	Q9JHJ7, Q9DA14	Gene names	Prss21
Domain Architecture
Description	Testisin precursor (EC 3.4.21.-) (Tryptase 4).

THRB_HUMAN
θ value	θ > 10 (rank : 253)	NC score	0.051056 (rank : 275)
Query Neighborhood Hits	96	Target Neighborhood Hits	196	Shared Neighborhood Hits	16
SwissProt Accessions	P00734	Gene names	F2
Domain Architecture
Description	Prothrombin precursor (EC 3.4.21.5) (Coagulation factor II) [Contains: Activation peptide fragment 1; Activation peptide fragment 2; Thrombin light chain; Thrombin heavy chain].

THRB_MOUSE
θ value	θ > 10 (rank : 254)	NC score	0.050203 (rank : 281)
Query Neighborhood Hits	96	Target Neighborhood Hits	195	Shared Neighborhood Hits	16
SwissProt Accessions	P19221	Gene names	F2, Cf2
Domain Architecture
Description	Prothrombin precursor (EC 3.4.21.5) (Coagulation factor II) [Contains: Activation peptide fragment 1; Activation peptide fragment 2; Thrombin light chain; Thrombin heavy chain].

TLL1_HUMAN
θ value	θ > 10 (rank : 255)	NC score	0.067312 (rank : 155)
Query Neighborhood Hits	96	Target Neighborhood Hits	236	Shared Neighborhood Hits	34
SwissProt Accessions	O43897, Q96AN3, Q9NQS4	Gene names	TLL1, TLL
Domain Architecture	No domain graphic available
Description	Tolloid-like protein 1 precursor (EC 3.4.24.-).

TLL1_MOUSE
θ value	θ > 10 (rank : 256)	NC score	0.067627 (rank : 154)
Query Neighborhood Hits	96	Target Neighborhood Hits	237	Shared Neighborhood Hits	36
SwissProt Accessions	Q62381, Q3UTT9, Q8BNP5	Gene names	Tll1, Tll
Domain Architecture	No domain graphic available
Description	Tolloid-like protein 1 precursor (EC 3.4.24.-) (mTll).

TLL2_HUMAN
θ value	θ > 10 (rank : 257)	NC score	0.064993 (rank : 169)
Query Neighborhood Hits	96	Target Neighborhood Hits	241	Shared Neighborhood Hits	36
SwissProt Accessions	Q9Y6L7, Q6PJN5, Q9UQ00	Gene names	TLL2, KIAA0932
Domain Architecture	No domain graphic available
Description	Tolloid-like protein 2 precursor (EC 3.4.24.-).

TLL2_MOUSE
θ value	θ > 10 (rank : 258)	NC score	0.065664 (rank : 162)
Query Neighborhood Hits	96	Target Neighborhood Hits	240	Shared Neighborhood Hits	36
SwissProt Accessions	Q9WVM6	Gene names	Tll2
Domain Architecture	No domain graphic available
Description	Tolloid-like protein 2 precursor (EC 3.4.24.-).

TM11D_HUMAN
θ value	θ > 10 (rank : 259)	NC score	0.056532 (rank : 219)
Query Neighborhood Hits	96	Target Neighborhood Hits	176	Shared Neighborhood Hits	16
SwissProt Accessions	O60235	Gene names	TMPRSS11D, HAT
Domain Architecture
Description	Transmembrane protease, serine 11D precursor (EC 3.4.21.-) (Airway trypsin-like protease) [Contains: Transmembrane protease, serine 11D non-catalytic chain; Transmembrane protease, serine 11D catalytic chain].

TM11D_MOUSE
θ value	θ > 10 (rank : 260)	NC score	0.057976 (rank : 207)
Query Neighborhood Hits	96	Target Neighborhood Hits	179	Shared Neighborhood Hits	16
SwissProt Accessions	Q8VHK8, Q7TNX3, Q8VDV1	Gene names	Tmprss11d, Mat
Domain Architecture	No domain graphic available
Description	Transmembrane protease, serine 11D precursor (EC 3.4.21.-) (Airway trypsin-like protease) (AT) (Adrenal secretory serine protease) (AsP) [Contains: Transmembrane protease, serine 11D non-catalytic chain; Transmembrane protease, serine 11D catalytic chain].

TM11E_HUMAN
θ value	θ > 10 (rank : 261)	NC score	0.060485 (rank : 187)
Query Neighborhood Hits	96	Target Neighborhood Hits	181	Shared Neighborhood Hits	16
SwissProt Accessions	Q9UL52, Q6UW31	Gene names	TMPRSS11E, DESC1
Domain Architecture	No domain graphic available
Description	Transmembrane protease, serine 11E precursor (EC 3.4.21.-) (Serine protease DESC1) [Contains: Transmembrane protease, serine 11E non- catalytic chain; Transmembrane protease, serine 11E catalytic chain].

TM11E_MOUSE
θ value	θ > 10 (rank : 262)	NC score	0.059046 (rank : 199)
Query Neighborhood Hits	96	Target Neighborhood Hits	176	Shared Neighborhood Hits	16
SwissProt Accessions	Q5S248, Q8BM10	Gene names	Tmprss11e, Desc1
Domain Architecture	No domain graphic available
Description	Transmembrane protease, serine 11E precursor (EC 3.4.21.-) (Serine protease DESC1) [Contains: Transmembrane protease, serine 11E non- catalytic chain; Transmembrane protease, serine 11E catalytic chain].

TMPS2_HUMAN
θ value	θ > 10 (rank : 263)	NC score	0.081525 (rank : 105)
Query Neighborhood Hits	96	Target Neighborhood Hits	252	Shared Neighborhood Hits	48
SwissProt Accessions	O15393, Q9BXX1	Gene names	TMPRSS2, PRSS10
Domain Architecture
Description	Transmembrane protease, serine 2 precursor (EC 3.4.21.-) [Contains: Transmembrane protease, serine 2 non-catalytic chain; Transmembrane protease, serine 2 catalytic chain].

TMPS3_MOUSE
θ value	θ > 10 (rank : 264)	NC score	0.075796 (rank : 115)
Query Neighborhood Hits	96	Target Neighborhood Hits	239	Shared Neighborhood Hits	53
SwissProt Accessions	Q8K1T0, Q8VDE0	Gene names	Tmprss3
Domain Architecture
Description	Transmembrane protease, serine 3 (EC 3.4.21.-).

TMPS4_HUMAN
θ value	θ > 10 (rank : 265)	NC score	0.066651 (rank : 160)
Query Neighborhood Hits	96	Target Neighborhood Hits	203	Shared Neighborhood Hits	37
SwissProt Accessions	Q9NRS4, Q5XKQ6, Q6UX37, Q9NZA5	Gene names	TMPRSS4, TMPRSS3
Domain Architecture
Description	Transmembrane protease, serine 4 (EC 3.4.21.-) (Membrane-type serine protease 2) (MT-SP2).

TMPS4_MOUSE
θ value	θ > 10 (rank : 266)	NC score	0.064363 (rank : 170)
Query Neighborhood Hits	96	Target Neighborhood Hits	210	Shared Neighborhood Hits	36
SwissProt Accessions	Q8VCA5	Gene names	Tmprss4, Cap2
Domain Architecture
Description	Transmembrane protease, serine 4 (EC 3.4.21.-) (Channel-activating protease 2) (mCAP2).

TMPS5_HUMAN
θ value	θ > 10 (rank : 267)	NC score	0.057298 (rank : 214)
Query Neighborhood Hits	96	Target Neighborhood Hits	181	Shared Neighborhood Hits	16
SwissProt Accessions	Q9H3S3	Gene names	TMPRSS5
Domain Architecture
Description	Transmembrane protease, serine 5 (EC 3.4.21.-) (Spinesin).

TMPS5_MOUSE
θ value	θ > 10 (rank : 268)	NC score	0.057138 (rank : 215)
Query Neighborhood Hits	96	Target Neighborhood Hits	185	Shared Neighborhood Hits	16
SwissProt Accessions	Q9ER04, Q9ER02, Q9ER03	Gene names	Tmprss5
Domain Architecture
Description	Transmembrane protease, serine 5 (EC 3.4.21.-) (Spinesin).

TMPSD_HUMAN
θ value	θ > 10 (rank : 269)	NC score	0.061939 (rank : 183)
Query Neighborhood Hits	96	Target Neighborhood Hits	333	Shared Neighborhood Hits	32
SwissProt Accessions	Q9BYE2, Q86YM4, Q96JY8, Q9BYE1	Gene names	TMPRSS13, MSP, TMPRSS11
Domain Architecture	No domain graphic available
Description	Transmembrane protease, serine 13 (EC 3.4.21.-) (Mosaic serine protease) (Membrane-type mosaic serine protease).

TMPSD_MOUSE
θ value	θ > 10 (rank : 270)	NC score	0.059865 (rank : 195)
Query Neighborhood Hits	96	Target Neighborhood Hits	334	Shared Neighborhood Hits	23
SwissProt Accessions	Q5U405, Q8CFE0, Q91VQ8	Gene names	Tmprss13, Msp
Domain Architecture	No domain graphic available
Description	Transmembrane protease, serine 13 (EC 3.4.21.-) (Mosaic serine protease) (Membrane-type mosaic serine protease).

TMSP8_MOUSE
θ value	θ > 10 (rank : 271)	NC score	0.054729 (rank : 239)
Query Neighborhood Hits	96	Target Neighborhood Hits	176	Shared Neighborhood Hits	18
SwissProt Accessions	Q9QYZ9, Q91XC4	Gene names	Tmprss8, Disp
Domain Architecture
Description	Transmembrane serine protease 8 precursor (EC 3.4.21.-) (Distal intestinal serine protease).

TPA_HUMAN
θ value	θ > 10 (rank : 272)	NC score	0.056658 (rank : 216)
Query Neighborhood Hits	96	Target Neighborhood Hits	324	Shared Neighborhood Hits	27
SwissProt Accessions	P00750, Q15103, Q7Z7N2, Q86YK8, Q9BU99	Gene names	PLAT
Domain Architecture
Description	Tissue-type plasminogen activator precursor (EC 3.4.21.68) (tPA) (t- PA) (t-plasminogen activator) (Alteplase) (Reteplase) [Contains: Tissue-type plasminogen activator chain A; Tissue-type plasminogen activator chain B].

TPA_MOUSE
θ value	θ > 10 (rank : 273)	NC score	0.055747 (rank : 225)
Query Neighborhood Hits	96	Target Neighborhood Hits	335	Shared Neighborhood Hits	27
SwissProt Accessions	P11214, Q91VP2	Gene names	Plat
Domain Architecture
Description	Tissue-type plasminogen activator precursor (EC 3.4.21.68) (tPA) (t- PA) (t-plasminogen activator) [Contains: Tissue-type plasminogen activator chain A; Tissue-type plasminogen activator chain B].

TRBM_HUMAN
θ value	θ > 10 (rank : 274)	NC score	0.073257 (rank : 129)
Query Neighborhood Hits	96	Target Neighborhood Hits	339	Shared Neighborhood Hits	32
SwissProt Accessions	P07204, Q9UC32	Gene names	THBD, THRM
Domain Architecture
Description	Thrombomodulin precursor (TM) (Fetomodulin) (CD141 antigen).

TRBM_MOUSE
θ value	θ > 10 (rank : 275)	NC score	0.075499 (rank : 117)
Query Neighborhood Hits	96	Target Neighborhood Hits	361	Shared Neighborhood Hits	32
SwissProt Accessions	P15306	Gene names	Thbd
Domain Architecture
Description	Thrombomodulin precursor (TM) (Fetomodulin) (CD141 antigen).

TRYA1_HUMAN
θ value	θ > 10 (rank : 276)	NC score	0.051528 (rank : 269)
Query Neighborhood Hits	96	Target Neighborhood Hits	177	Shared Neighborhood Hits	16
SwissProt Accessions	P15157, Q9H2Y5, Q9UQI1	Gene names	TPSAB1, TPS1
Domain Architecture
Description	Tryptase alpha-1 precursor (EC 3.4.21.59) (Tryptase-1).

TRYB1_HUMAN
θ value	θ > 10 (rank : 277)	NC score	0.051680 (rank : 264)
Query Neighborhood Hits	96	Target Neighborhood Hits	175	Shared Neighborhood Hits	16
SwissProt Accessions	Q15661, Q15663, Q9H2Y4	Gene names	TPSAB1, TPSB1
Domain Architecture
Description	Tryptase beta-1 precursor (EC 3.4.21.59) (Tryptase-1) (Tryptase I).

TRYB1_MOUSE
θ value	θ > 10 (rank : 278)	NC score	0.051548 (rank : 268)
Query Neighborhood Hits	96	Target Neighborhood Hits	175	Shared Neighborhood Hits	16
SwissProt Accessions	Q02844	Gene names	Tpsab1, Mcpt7
Domain Architecture
Description	Tryptase precursor (EC 3.4.21.59) (Mast cell protease 7) (MMCP-7) (Tryptase alpha/beta-1).

TRYB2_HUMAN
θ value	θ > 10 (rank : 279)	NC score	0.051680 (rank : 265)
Query Neighborhood Hits	96	Target Neighborhood Hits	175	Shared Neighborhood Hits	16
SwissProt Accessions	P20231, O95827, Q15664, Q9UQI6, Q9UQI7	Gene names	TPSB2, TPS2
Domain Architecture
Description	Tryptase beta-2 precursor (EC 3.4.21.59) (Tryptase-2) (Tryptase II).

TRYD_HUMAN
θ value	θ > 10 (rank : 280)	NC score	0.050592 (rank : 280)
Query Neighborhood Hits	96	Target Neighborhood Hits	175	Shared Neighborhood Hits	16
SwissProt Accessions	Q9BZJ3, O95824, Q8TDI6, Q96L36, Q96RZ5, Q9H2Y6, Q9UQI8	Gene names	TPSD1
Domain Architecture
Description	Tryptase delta precursor (EC 3.4.21.59) (Delta tryptase) (Mast cell mMCP-7-like) (Tryptase-3) (HmMCP-3-like tryptase III).

TRYG1_HUMAN
θ value	θ > 10 (rank : 281)	NC score	0.054279 (rank : 246)
Query Neighborhood Hits	96	Target Neighborhood Hits	179	Shared Neighborhood Hits	16
SwissProt Accessions	Q9NRR2, Q96RZ8, Q9C015, Q9NRQ8, Q9UBB2	Gene names	TPSG1, TMT
Domain Architecture
Description	Tryptase gamma precursor (EC 3.4.21.-) (Transmembrane tryptase) [Contains: Tryptase gamma light chain; Tryptase gamma heavy chain].

TRYG1_MOUSE
θ value	θ > 10 (rank : 282)	NC score	0.054265 (rank : 247)
Query Neighborhood Hits	96	Target Neighborhood Hits	181	Shared Neighborhood Hits	16
SwissProt Accessions	Q9QUL7	Gene names	Tpsg1, Tmt
Domain Architecture
Description	Tryptase gamma precursor (EC 3.4.21.-) (Transmembrane tryptase) [Contains: Tryptase gamma light chain; Tryptase gamma heavy chain].

TSP50_HUMAN
θ value	θ > 10 (rank : 283)	NC score	0.054631 (rank : 240)
Query Neighborhood Hits	96	Target Neighborhood Hits	178	Shared Neighborhood Hits	16
SwissProt Accessions	Q9UI38	Gene names	TSP50
Domain Architecture
Description	Testis-specific protease-like protein 50 precursor.

UROK_HUMAN
θ value	θ > 10 (rank : 284)	NC score	0.052647 (rank : 259)
Query Neighborhood Hits	96	Target Neighborhood Hits	272	Shared Neighborhood Hits	24
SwissProt Accessions	P00749, Q15844, Q16618, Q969W6	Gene names	PLAU
Domain Architecture
Description	Urokinase-type plasminogen activator precursor (EC 3.4.21.73) (uPA) (U-plasminogen activator) [Contains: Urokinase-type plasminogen activator long chain A; Urokinase-type plasminogen activator short chain A; Urokinase-type plasminogen activator chain B].

UROK_MOUSE
θ value	θ > 10 (rank : 285)	NC score	0.053492 (rank : 252)
Query Neighborhood Hits	96	Target Neighborhood Hits	273	Shared Neighborhood Hits	24
SwissProt Accessions	P06869	Gene names	Plau
Domain Architecture
Description	Urokinase-type plasminogen activator precursor (EC 3.4.21.73) (uPA) (U-plasminogen activator) [Contains: Urokinase-type plasminogen activator long chain A; Urokinase-type plasminogen activator short chain A; Urokinase-type plasminogen activator chain B].

UROM_HUMAN
θ value	θ > 10 (rank : 286)	NC score	0.051384 (rank : 270)
Query Neighborhood Hits	96	Target Neighborhood Hits	284	Shared Neighborhood Hits	25
SwissProt Accessions	P07911, Q540J6, Q6ZS84, Q8IYG0	Gene names	UMOD
Domain Architecture
Description	Uromodulin precursor (Tamm-Horsfall urinary glycoprotein) (THP).

UROM_MOUSE
θ value	θ > 10 (rank : 287)	NC score	0.050795 (rank : 277)
Query Neighborhood Hits	96	Target Neighborhood Hits	276	Shared Neighborhood Hits	25
SwissProt Accessions	Q91X17, Q3TN64, Q3TP60, Q62285	Gene names	Umod
Domain Architecture	No domain graphic available
Description	Uromodulin precursor (Tamm-Horsfall urinary glycoprotein) (THP).

WFD15_MOUSE
θ value	θ > 10 (rank : 288)	NC score	0.077662 (rank : 110)
Query Neighborhood Hits	96	Target Neighborhood Hits	17	Shared Neighborhood Hits	4
SwissProt Accessions	Q9JHY4, Q8BVC0	Gene names	Wfdc15, Swam1
Domain Architecture
Description	WAP four-disulfide core domain protein 15 precursor (Single WAP motif protein 1) (Elafin-like protein I).

WFDC3_HUMAN
θ value	θ > 10 (rank : 289)	NC score	0.055074 (rank : 235)
Query Neighborhood Hits	96	Target Neighborhood Hits	138	Shared Neighborhood Hits	16
SwissProt Accessions	Q8IUB2, Q8TC52, Q9BQP3, Q9BQP4	Gene names	WFDC3, WAP14
Domain Architecture	No domain graphic available
Description	WAP four-disulfide core domain protein 3 precursor (Putative protease inhibitor WAP14).

Hits sorted by NC score

SPIT1_MOUSE
NC score	0.999962 (rank : 1)	θ value	0 (rank : 2)
Query Neighborhood Hits	96	Target Neighborhood Hits	96	Shared Neighborhood Hits	96
SwissProt Accessions	Q9R097	Gene names	Spint1, Hai1
Domain Architecture
Description	Kunitz-type protease inhibitor 1 precursor (Hepatocyte growth factor activator inhibitor type 1) (HAI-1).

SPIT1_HUMAN
NC score	0.987749 (rank : 2)	θ value	0 (rank : 1)
Query Neighborhood Hits	96	Target Neighborhood Hits	100	Shared Neighborhood Hits	81
SwissProt Accessions	O43278, Q7Z7D2	Gene names	SPINT1, HAI1
Domain Architecture
Description	Kunitz-type protease inhibitor 1 precursor (Hepatocyte growth factor activator inhibitor type 1) (HAI-1).

SPIT2_HUMAN
NC score	0.740255 (rank : 3)	θ value	4.73814e-25 (rank : 3)
Query Neighborhood Hits	96	Target Neighborhood Hits	21	Shared Neighborhood Hits	20
SwissProt Accessions	O43291, O00271, O14895, Q5TZQ3, Q969E0	Gene names	SPINT2, HAI2, KOP
Domain Architecture
Description	Kunitz-type protease inhibitor 2 precursor (Hepatocyte growth factor activator inhibitor type 2) (HAI-2) (Placental bikunin).

TFPI2_HUMAN
NC score	0.722076 (rank : 4)	θ value	2.69047e-20 (rank : 7)
Query Neighborhood Hits	96	Target Neighborhood Hits	24	Shared Neighborhood Hits	20
SwissProt Accessions	P48307	Gene names	TFPI2
Domain Architecture
Description	Tissue factor pathway inhibitor 2 precursor (TFPI-2) (Placental protein 5) (PP5).

TFPI2_MOUSE
NC score	0.719728 (rank : 5)	θ value	7.82807e-20 (rank : 9)
Query Neighborhood Hits	96	Target Neighborhood Hits	23	Shared Neighborhood Hits	20
SwissProt Accessions	O35536	Gene names	Tfpi2
Domain Architecture
Description	Tissue factor pathway inhibitor 2 precursor (TFPI-2).

SPIT2_MOUSE
NC score	0.715525 (rank : 6)	θ value	4.9032e-22 (rank : 6)
Query Neighborhood Hits	96	Target Neighborhood Hits	24	Shared Neighborhood Hits	21
SwissProt Accessions	Q9WU03, Q9WU04, Q9WU05	Gene names	Spint2, Hai2
Domain Architecture
Description	Kunitz-type protease inhibitor 2 precursor (Hepatocyte growth factor activator inhibitor type 2) (HAI-2).

TFPI1_HUMAN
NC score	0.706271 (rank : 7)	θ value	3.51386e-20 (rank : 8)
Query Neighborhood Hits	96	Target Neighborhood Hits	20	Shared Neighborhood Hits	20
SwissProt Accessions	P10646, O95103	Gene names	TFPI, LACI, TFPI1
Domain Architecture
Description	Tissue factor pathway inhibitor precursor (TFPI) (Lipoprotein- associated coagulation inhibitor) (LACI) (Extrinsic pathway inhibitor) (EPI).

TFPI1_MOUSE
NC score	0.701843 (rank : 8)	θ value	1.74391e-19 (rank : 10)
Query Neighborhood Hits	96	Target Neighborhood Hits	22	Shared Neighborhood Hits	20
SwissProt Accessions	O54819, Q9Z2U8	Gene names	Tfpi
Domain Architecture
Description	Tissue factor pathway inhibitor precursor (TFPI) (Lipoprotein- associated coagulation inhibitor) (LACI) (Extrinsic pathway inhibitor) (EPI).

SPIT3_HUMAN
NC score	0.661422 (rank : 9)	θ value	7.1131e-05 (rank : 23)
Query Neighborhood Hits	96	Target Neighborhood Hits	20	Shared Neighborhood Hits	20
SwissProt Accessions	P49223, Q6UDR8, Q96KK2	Gene names	SPINT3
Domain Architecture	No domain graphic available
Description	Kunitz-type protease inhibitor 3 precursor (HKIB9).

LRP11_MOUSE
NC score	0.594815 (rank : 10)	θ value	2.35151e-24 (rank : 4)
Query Neighborhood Hits	96	Target Neighborhood Hits	81	Shared Neighborhood Hits	63
SwissProt Accessions	Q8CB67, Q8C7Y7	Gene names	Lrp11
Domain Architecture
Description	Low-density lipoprotein receptor-related protein 11 precursor.

LRP11_HUMAN
NC score	0.589525 (rank : 11)	θ value	3.75424e-22 (rank : 5)
Query Neighborhood Hits	96	Target Neighborhood Hits	82	Shared Neighborhood Hits	58
SwissProt Accessions	Q86VZ4, Q5VYC0, Q96SN6	Gene names	LRP11
Domain Architecture
Description	Low-density lipoprotein receptor-related protein 11 precursor.

EPPI_HUMAN
NC score	0.575912 (rank : 12)	θ value	5.26297e-08 (rank : 17)
Query Neighborhood Hits	96	Target Neighborhood Hits	33	Shared Neighborhood Hits	20
SwissProt Accessions	O95925, Q86TP9, Q96SD7, Q9HD30	Gene names	SPINLW1, WAP7, WFDC7
Domain Architecture
Description	Eppin precursor (Epididymal protease inhibitor) (Serine protease inhibitor-like with Kunitz and WAP domains 1) (WAP four-disulfide core domain protein 7) (Protease inhibitor WAP7).

EPPI_MOUSE
NC score	0.573727 (rank : 13)	θ value	2.61198e-07 (rank : 19)
Query Neighborhood Hits	96	Target Neighborhood Hits	43	Shared Neighborhood Hits	23
SwissProt Accessions	Q9DA01	Gene names	Spinlw1
Domain Architecture
Description	Eppin precursor (Epididymal protease inhibitor) (Serine protease inhibitor-like with Kunitz and WAP domains 1).

AMBP_HUMAN
NC score	0.544641 (rank : 14)	θ value	5.08577e-11 (rank : 12)
Query Neighborhood Hits	96	Target Neighborhood Hits	46	Shared Neighborhood Hits	20
SwissProt Accessions	P02760, P00977, P02759	Gene names	AMBP, HCP, ITIL
Domain Architecture
Description	AMBP protein precursor [Contains: Alpha-1-microglobulin (Protein HC) (Complex-forming glycoprotein heterogeneous in charge) (Alpha-1 microglycoprotein); Inter-alpha-trypsin inhibitor light chain (ITI-LC) (Bikunin) (HI-30)].

AMBP_MOUSE
NC score	0.535442 (rank : 15)	θ value	1.33837e-11 (rank : 11)
Query Neighborhood Hits	96	Target Neighborhood Hits	48	Shared Neighborhood Hits	20
SwissProt Accessions	Q07456, Q61294	Gene names	Ambp, Itil
Domain Architecture
Description	AMBP protein precursor [Contains: Alpha-1-microglobulin; Inter-alpha- trypsin inhibitor light chain (ITI-LC) (Bikunin) (HI-30)].

WFDC8_HUMAN
NC score	0.485813 (rank : 16)	θ value	8.97725e-08 (rank : 18)
Query Neighborhood Hits	96	Target Neighborhood Hits	82	Shared Neighborhood Hits	22
SwissProt Accessions	Q8IUA0, Q5TDV2, Q96A34	Gene names	WFDC8, C20orf170, WAP8
Domain Architecture
Description	WAP four-disulfide core domain protein 8 precursor (Putative protease inhibitor WAP8).

A4_MOUSE
NC score	0.427045 (rank : 17)	θ value	3.29651e-10 (rank : 15)
Query Neighborhood Hits	96	Target Neighborhood Hits	275	Shared Neighborhood Hits	20
SwissProt Accessions	P12023, P97487, P97942, Q99K32	Gene names	App
Domain Architecture	No domain graphic available
Description	Amyloid beta A4 protein precursor (APP) (ABPP) (Alzheimer disease amyloid protein homolog) (Amyloidogenic glycoprotein) (AG) [Contains: Soluble APP-alpha (S-APP-alpha); Soluble APP-beta (S-APP-beta); C99 (APP-C99); Beta-amyloid protein 42 (Beta-APP42); Beta-amyloid protein 40 (Beta-APP40); C83; P3(42); P3(40); Gamma-CTF(59) (Gamma-secretase C-terminal fragment 59) (Amyloid intracellular domain 59) (AID(59)) (APP-C59); Gamma-CTF(57) (Gamma-secretase C-terminal fragment 57) (Amyloid intracellular domain 57) (AID(57)) (APP-C57); Gamma-CTF(50) (Gamma-secretase C-terminal fragment 50) (Amyloid intracellular domain 50) (AID(50)); C31].

A4_HUMAN
NC score	0.423960 (rank : 18)	θ value	3.29651e-10 (rank : 14)
Query Neighborhood Hits	96	Target Neighborhood Hits	274	Shared Neighborhood Hits	20
SwissProt Accessions	P05067, P09000, P78438, Q13764, Q13778, Q13793, Q16011, Q16014, Q16019, Q16020, Q9BT38, Q9UCA9, Q9UCB6, Q9UCC8, Q9UCD1, Q9UQ58	Gene names	APP, A4, AD1
Domain Architecture	No domain graphic available
Description	Amyloid beta A4 protein precursor (APP) (ABPP) (Alzheimer disease amyloid protein) (Cerebral vascular amyloid peptide) (CVAP) (Protease nexin-II) (PN-II) (APPI) (PreA4) [Contains: Soluble APP-alpha (S-APP- alpha); Soluble APP-beta (S-APP-beta); C99; Beta-amyloid protein 42 (Beta-APP42); Beta-amyloid protein 40 (Beta-APP40); C83; P3(42); P3(40); Gamma-CTF(59) (Gamma-secretase C-terminal fragment 59) (Amyloid intracellular domain 59) (AID(59)); Gamma-CTF(57) (Gamma- secretase C-terminal fragment 57) (Amyloid intracellular domain 57) (AID(57)); Gamma-CTF(50) (Gamma-secretase C-terminal fragment 50) (Amyloid intracellular domain 50) (AID(50)); C31].

APLP2_HUMAN
NC score	0.422605 (rank : 19)	θ value	1.47974e-10 (rank : 13)
Query Neighborhood Hits	96	Target Neighborhood Hits	193	Shared Neighborhood Hits	20
SwissProt Accessions	Q06481	Gene names	APLP2, APPL2
Domain Architecture
Description	Amyloid-like protein 2 precursor (Amyloid protein homolog) (APPH) (CDEI box-binding protein) (CDEBP).

CD320_HUMAN
NC score	0.398176 (rank : 20)	θ value	0.0252991 (rank : 52)
Query Neighborhood Hits	96	Target Neighborhood Hits	103	Shared Neighborhood Hits	63
SwissProt Accessions	Q9NPF0, Q53HF7	Gene names	CD320, 8D6A
Domain Architecture	No domain graphic available
Description	CD320 antigen precursor (8D6 antigen) (FDC-signaling molecule 8D6) (FDC-SM-8D6).

WFDC6_HUMAN
NC score	0.364053 (rank : 21)	θ value	0.0252991 (rank : 53)
Query Neighborhood Hits	96	Target Neighborhood Hits	33	Shared Neighborhood Hits	20
SwissProt Accessions	Q9BQY6, Q5JYQ4, Q8NFV6	Gene names	WFDC6, C20orf171, WAP6
Domain Architecture
Description	WAP four-disulfide core domain protein 6 precursor (Putative protease inhibitor WAP6).

LRP5_MOUSE
NC score	0.344339 (rank : 22)	θ value	0.000158464 (rank : 25)
Query Neighborhood Hits	96	Target Neighborhood Hits	236	Shared Neighborhood Hits	67
SwissProt Accessions	Q91VN0, O88883, Q9R208	Gene names	Lrp5, Lrp7
Domain Architecture
Description	Low-density lipoprotein receptor-related protein 5 precursor (LRP7) (Lr3).

LRP5_HUMAN
NC score	0.342422 (rank : 23)	θ value	0.000270298 (rank : 30)
Query Neighborhood Hits	96	Target Neighborhood Hits	224	Shared Neighborhood Hits	66
SwissProt Accessions	O75197, Q96TD6, Q9UP66	Gene names	LRP5, LRP7
Domain Architecture
Description	Low-density lipoprotein receptor-related protein 5 precursor.

LRP6_MOUSE
NC score	0.339528 (rank : 24)	θ value	0.000461057 (rank : 36)
Query Neighborhood Hits	96	Target Neighborhood Hits	232	Shared Neighborhood Hits	67
SwissProt Accessions	O88572	Gene names	Lrp6
Domain Architecture
Description	Low-density lipoprotein receptor-related protein 6 precursor.

LRP6_HUMAN
NC score	0.339043 (rank : 25)	θ value	0.000461057 (rank : 35)
Query Neighborhood Hits	96	Target Neighborhood Hits	235	Shared Neighborhood Hits	67
SwissProt Accessions	O75581	Gene names	LRP6
Domain Architecture
Description	Low-density lipoprotein receptor-related protein 6 precursor.

LRP8_HUMAN
NC score	0.318370 (rank : 26)	θ value	0.00035302 (rank : 32)
Query Neighborhood Hits	96	Target Neighborhood Hits	346	Shared Neighborhood Hits	69
SwissProt Accessions	Q14114, O14968, Q86V27, Q99876, Q9BR78	Gene names	LRP8, APOER2
Domain Architecture
Description	Low-density lipoprotein receptor-related protein 8 precursor (Apolipoprotein E receptor 2).

LRP10_HUMAN
NC score	0.317837 (rank : 27)	θ value	0.279714 (rank : 67)
Query Neighborhood Hits	96	Target Neighborhood Hits	197	Shared Neighborhood Hits	65
SwissProt Accessions	Q7Z4F1, O95882, Q86T02, Q8NCZ4, Q9HC42, Q9UG33	Gene names	LRP10
Domain Architecture
Description	Low-density lipoprotein receptor-related protein 10 precursor.

LRP3_HUMAN
NC score	0.317692 (rank : 28)	θ value	0.000461057 (rank : 34)
Query Neighborhood Hits	96	Target Neighborhood Hits	280	Shared Neighborhood Hits	67
SwissProt Accessions	O75074	Gene names	LRP3
Domain Architecture
Description	Low-density lipoprotein receptor-related protein 3 precursor (hLRp105).

LRP10_MOUSE
NC score	0.317379 (rank : 29)	θ value	0.279714 (rank : 68)
Query Neighborhood Hits	96	Target Neighborhood Hits	169	Shared Neighborhood Hits	65
SwissProt Accessions	Q7TQH7, Q7TS95, Q921T0, Q9EPE8	Gene names	Lrp10, Lrp9
Domain Architecture
Description	Low-density lipoprotein receptor-related protein 10 precursor.

VLDLR_HUMAN
NC score	0.316833 (rank : 30)	θ value	0.000158464 (rank : 26)
Query Neighborhood Hits	96	Target Neighborhood Hits	383	Shared Neighborhood Hits	69
SwissProt Accessions	P98155, Q5VVF6	Gene names	VLDLR
Domain Architecture
Description	Very low-density lipoprotein receptor precursor (VLDL receptor) (VLDL- R).

VLDLR_MOUSE
NC score	0.315242 (rank : 31)	θ value	0.000158464 (rank : 27)
Query Neighborhood Hits	96	Target Neighborhood Hits	360	Shared Neighborhood Hits	69
SwissProt Accessions	P98156, Q64022	Gene names	Vldlr
Domain Architecture
Description	Very low-density lipoprotein receptor precursor (VLDL receptor) (VLDL- R).

SORL_MOUSE
NC score	0.314225 (rank : 32)	θ value	1.09739e-05 (rank : 21)
Query Neighborhood Hits	96	Target Neighborhood Hits	439	Shared Neighborhood Hits	70
SwissProt Accessions	O88307, O54711, O70581	Gene names	Sorl1
Domain Architecture
Description	Sortilin-related receptor precursor (Sorting protein-related receptor containing LDLR class A repeats) (mSorLA) (SorLA-1) (Low-density lipoprotein receptor relative with 11 ligand-binding repeats) (LDLR relative with 11 ligand-binding repeats) (LR11) (Gp250).

LRP8_MOUSE
NC score	0.314059 (rank : 33)	θ value	0.00035302 (rank : 33)
Query Neighborhood Hits	96	Target Neighborhood Hits	385	Shared Neighborhood Hits	69
SwissProt Accessions	Q924X6, Q8CAK9, Q8CDF5, Q921B6	Gene names	Lrp8, Apoer2
Domain Architecture
Description	Low-density lipoprotein receptor-related protein 8 precursor (Apolipoprotein E receptor 2).

LDLR_MOUSE
NC score	0.313562 (rank : 34)	θ value	0.000786445 (rank : 38)
Query Neighborhood Hits	96	Target Neighborhood Hits	382	Shared Neighborhood Hits	69
SwissProt Accessions	P35951	Gene names	Ldlr
Domain Architecture
Description	Low-density lipoprotein receptor precursor (LDL receptor).

LRP4_HUMAN
NC score	0.311167 (rank : 35)	θ value	0.00390308 (rank : 45)
Query Neighborhood Hits	96	Target Neighborhood Hits	355	Shared Neighborhood Hits	69
SwissProt Accessions	O75096	Gene names	LRP4, KIAA0816, MEGF7
Domain Architecture
Description	Low-density lipoprotein receptor-related protein 4 precursor (Multiple epidermal growth factor-like domains 7).

LRP4_MOUSE
NC score	0.311020 (rank : 36)	θ value	0.00134147 (rank : 40)
Query Neighborhood Hits	96	Target Neighborhood Hits	351	Shared Neighborhood Hits	69
SwissProt Accessions	Q8VI56, Q8BPX5, Q8CBB3, Q8CCP5	Gene names	Lrp4, Kiaa0816
Domain Architecture
Description	Low-density lipoprotein receptor-related protein 4 precursor (LDLR dan).

LDLR_HUMAN
NC score	0.309039 (rank : 37)	θ value	0.00020696 (rank : 28)
Query Neighborhood Hits	96	Target Neighborhood Hits	375	Shared Neighborhood Hits	69
SwissProt Accessions	P01130, Q53ZD9	Gene names	LDLR
Domain Architecture
Description	Low-density lipoprotein receptor precursor (LDL receptor).

SORL_HUMAN
NC score	0.306921 (rank : 38)	θ value	0.00020696 (rank : 29)
Query Neighborhood Hits	96	Target Neighborhood Hits	440	Shared Neighborhood Hits	68
SwissProt Accessions	Q92673, Q92856	Gene names	SORL1
Domain Architecture
Description	Sortilin-related receptor precursor (Sorting protein-related receptor containing LDLR class A repeats) (SorLA) (SorLA-1) (Low-density lipoprotein receptor relative with 11 ligand-binding repeats) (LDLR relative with 11 ligand-binding repeats) (LR11).

LRP2_HUMAN
NC score	0.306774 (rank : 39)	θ value	0.000786445 (rank : 39)
Query Neighborhood Hits	96	Target Neighborhood Hits	573	Shared Neighborhood Hits	70
SwissProt Accessions	P98164, O00711, Q16215	Gene names	LRP2
Domain Architecture
Description	Low-density lipoprotein receptor-related protein 2 precursor (Megalin) (Glycoprotein 330) (gp330).

LRP1B_HUMAN
NC score	0.288710 (rank : 40)	θ value	3.77169e-06 (rank : 20)
Query Neighborhood Hits	96	Target Neighborhood Hits	602	Shared Neighborhood Hits	69
SwissProt Accessions	Q9NZR2, Q8WY29, Q8WY30, Q8WY31	Gene names	LRP1B, LRPDIT
Domain Architecture
Description	Low-density lipoprotein receptor-related protein 1B precursor (Low- density lipoprotein receptor-related protein-deleted in tumor) (LRP- DIT).

LRP1B_MOUSE
NC score	0.288417 (rank : 41)	θ value	3.19293e-05 (rank : 22)
Query Neighborhood Hits	96	Target Neighborhood Hits	606	Shared Neighborhood Hits	69
SwissProt Accessions	Q9JI18, Q8BZD3, Q8BZM7	Gene names	Lrp1b, Lrpdit
Domain Architecture
Description	Low-density lipoprotein receptor-related protein 1B precursor (Low- density lipoprotein receptor-related protein-deleted in tumor) (LRP- DIT).

LRP1_HUMAN
NC score	0.286778 (rank : 42)	θ value	0.00035302 (rank : 31)
Query Neighborhood Hits	96	Target Neighborhood Hits	617	Shared Neighborhood Hits	71
SwissProt Accessions	Q07954, Q2PP12, Q8IVG8	Gene names	LRP1, A2MR
Domain Architecture
Description	Low-density lipoprotein receptor-related protein 1 precursor (LRP) (Alpha-2-macroglobulin receptor) (A2MR) (Apolipoprotein E receptor) (APOER) (CD91 antigen).

LRP12_HUMAN
NC score	0.284990 (rank : 43)	θ value	0.0193708 (rank : 50)
Query Neighborhood Hits	96	Target Neighborhood Hits	205	Shared Neighborhood Hits	62
SwissProt Accessions	Q9Y561	Gene names	LRP12, ST7
Domain Architecture
Description	Low-density lipoprotein receptor-related protein 12 precursor (Suppressor of tumorigenicity protein 7).

LRP12_MOUSE
NC score	0.280451 (rank : 44)	θ value	0.0736092 (rank : 59)
Query Neighborhood Hits	96	Target Neighborhood Hits	180	Shared Neighborhood Hits	62
SwissProt Accessions	Q8BUJ9, Q8BWM9	Gene names	Lrp12
Domain Architecture
Description	Low-density lipoprotein receptor-related protein 12 precursor.

CO9_HUMAN
NC score	0.225874 (rank : 45)	θ value	1.81305 (rank : 80)
Query Neighborhood Hits	96	Target Neighborhood Hits	147	Shared Neighborhood Hits	61
SwissProt Accessions	P02748	Gene names	C9
Domain Architecture
Description	Complement component C9 precursor [Contains: Complement component C9a; Complement component C9b].

IDD_HUMAN
NC score	0.219776 (rank : 46)	θ value	6.88961 (rank : 94)
Query Neighborhood Hits	96	Target Neighborhood Hits	127	Shared Neighborhood Hits	57
SwissProt Accessions	P98153	Gene names	DGCR2, IDD, KIAA0163
Domain Architecture
Description	Integral membrane protein DGCR2/IDD precursor.

CO6A3_HUMAN
NC score	0.213041 (rank : 47)	θ value	1.63604e-09 (rank : 16)
Query Neighborhood Hits	96	Target Neighborhood Hits	317	Shared Neighborhood Hits	20
SwissProt Accessions	P12111, Q16501	Gene names	COL6A3
Domain Architecture
Description	Collagen alpha-3(VI) chain precursor.

SSPO_MOUSE
NC score	0.212185 (rank : 48)	θ value	0.0431538 (rank : 55)
Query Neighborhood Hits	96	Target Neighborhood Hits	800	Shared Neighborhood Hits	70
SwissProt Accessions	Q8CG65	Gene names	Sspo
Domain Architecture	No domain graphic available
Description	SCO-spondin precursor.

IDD_MOUSE
NC score	0.207557 (rank : 49)	θ value	4.03905 (rank : 88)
Query Neighborhood Hits	96	Target Neighborhood Hits	151	Shared Neighborhood Hits	54
SwissProt Accessions	P98154, Q61844	Gene names	Dgcr2, Dgsc, Idd, Sez-12, Sez12
Domain Architecture
Description	Integral membrane protein DGCR2/IDD precursor (Seizure-related membrane-bound adhesion protein).

CO9_MOUSE
NC score	0.203345 (rank : 50)	θ value	0.62314 (rank : 71)
Query Neighborhood Hits	96	Target Neighborhood Hits	153	Shared Neighborhood Hits	59
SwissProt Accessions	P06683, Q91XA7	Gene names	C9
Domain Architecture
Description	Complement component C9 precursor.

ST14_HUMAN
NC score	0.195121 (rank : 51)	θ value	9.29e-05 (rank : 24)
Query Neighborhood Hits	96	Target Neighborhood Hits	409	Shared Neighborhood Hits	67
SwissProt Accessions	Q9Y5Y6, Q9BS01, Q9H3S0, Q9HB36, Q9HCA3	Gene names	ST14, PRSS14, SNC19, TADG15
Domain Architecture
Description	Suppressor of tumorigenicity protein 14 (EC 3.4.21.-) (Serine protease 14) (Matriptase) (Membrane-type serine protease 1) (MT-SP1) (Prostamin) (Serine protease TADG-15) (Tumor-associated differentially-expressed gene 15 protein).

CORIN_HUMAN
NC score	0.194016 (rank : 52)	θ value	0.00175202 (rank : 41)
Query Neighborhood Hits	96	Target Neighborhood Hits	453	Shared Neighborhood Hits	67
SwissProt Accessions	Q9Y5Q5, Q9UHY2	Gene names	CORIN, CRN, TMPRSS10
Domain Architecture
Description	Atrial natriuteric peptide-converting enzyme (EC 3.4.21.-) (pro-ANP- converting enzyme) (Corin) (Heart-specific serine proteinase ATC2) (Transmembrane protease, serine 10).

ST14_MOUSE
NC score	0.193147 (rank : 53)	θ value	0.00228821 (rank : 43)
Query Neighborhood Hits	96	Target Neighborhood Hits	419	Shared Neighborhood Hits	67
SwissProt Accessions	P56677	Gene names	St14, Prss14
Domain Architecture
Description	Suppressor of tumorigenicity protein 14 (EC 3.4.21.-) (Serine protease 14) (Epithin).

CORIN_MOUSE
NC score	0.189059 (rank : 54)	θ value	0.0113563 (rank : 47)
Query Neighborhood Hits	96	Target Neighborhood Hits	451	Shared Neighborhood Hits	67
SwissProt Accessions	Q9Z319	Gene names	Corin, Crn, Lrp4
Domain Architecture
Description	Atrial natriuteric peptide-converting enzyme (EC 3.4.21.-) (pro-ANP- converting enzyme) (Corin) (Low density lipoprotein receptor-related protein 4).

TMPS7_HUMAN
NC score	0.168347 (rank : 55)	θ value	0.0113563 (rank : 48)
Query Neighborhood Hits	96	Target Neighborhood Hits	275	Shared Neighborhood Hits	60
SwissProt Accessions	Q7RTY8	Gene names	TMPRSS7
Domain Architecture	No domain graphic available
Description	Transmembrane protease, serine 7 precursor (EC 3.4.21.-).

MFRP_HUMAN
NC score	0.168281 (rank : 56)	θ value	0.163984 (rank : 63)
Query Neighborhood Hits	96	Target Neighborhood Hits	165	Shared Neighborhood Hits	57
SwissProt Accessions	Q9BY79, Q335M3, Q96DQ9	Gene names	MFRP
Domain Architecture	No domain graphic available
Description	Membrane frizzled-related protein (Membrane-type frizzled-related protein).

TMPS7_MOUSE
NC score	0.167420 (rank : 57)	θ value	0.0563607 (rank : 58)
Query Neighborhood Hits	96	Target Neighborhood Hits	275	Shared Neighborhood Hits	63
SwissProt Accessions	Q8BIK6	Gene names	Tmprss7
Domain Architecture	No domain graphic available
Description	Transmembrane protease, serine 7 precursor (EC 3.4.21.-).

EGF_HUMAN
NC score	0.164456 (rank : 58)	θ value	θ > 10 (rank : 134)
Query Neighborhood Hits	96	Target Neighborhood Hits	343	Shared Neighborhood Hits	31
SwissProt Accessions	P01133	Gene names	EGF
Domain Architecture
Description	Pro-epidermal growth factor precursor (EGF) [Contains: Epidermal growth factor (Urogastrone)].

CO6_HUMAN
NC score	0.162558 (rank : 59)	θ value	0.365318 (rank : 69)
Query Neighborhood Hits	96	Target Neighborhood Hits	331	Shared Neighborhood Hits	66
SwissProt Accessions	P13671	Gene names	C6
Domain Architecture
Description	Complement component C6 precursor.

EGF_MOUSE
NC score	0.156430 (rank : 60)	θ value	θ > 10 (rank : 135)
Query Neighborhood Hits	96	Target Neighborhood Hits	358	Shared Neighborhood Hits	31
SwissProt Accessions	P01132, Q6P9J2	Gene names	Egf
Domain Architecture
Description	Pro-epidermal growth factor precursor (EGF) [Contains: Epidermal growth factor].

CFAI_HUMAN
NC score	0.153965 (rank : 61)	θ value	0.125558 (rank : 61)
Query Neighborhood Hits	96	Target Neighborhood Hits	289	Shared Neighborhood Hits	63
SwissProt Accessions	P05156, O60442	Gene names	CFI, IF
Domain Architecture
Description	Complement factor I precursor (EC 3.4.21.45) (C3B/C4B inactivator) [Contains: Complement factor I heavy chain; Complement factor I light chain].

MFRP_MOUSE
NC score	0.153040 (rank : 62)	θ value	0.365318 (rank : 70)
Query Neighborhood Hits	96	Target Neighborhood Hits	166	Shared Neighborhood Hits	59
SwissProt Accessions	Q8K480, Q8BPP4	Gene names	Mfrp
Domain Architecture	No domain graphic available
Description	Membrane frizzled-related protein (Membrane-type frizzled-related protein).

TMPS6_HUMAN
NC score	0.148247 (rank : 63)	θ value	0.813845 (rank : 74)
Query Neighborhood Hits	96	Target Neighborhood Hits	338	Shared Neighborhood Hits	66
SwissProt Accessions	Q8IU80, Q5TI06, Q6UXD8, Q8IUE2, Q8IXV8	Gene names	TMPRSS6
Domain Architecture
Description	Transmembrane protease, serine 6 (EC 3.4.21.-) (Matriptase-2).

CR001_HUMAN
NC score	0.145940 (rank : 64)	θ value	4.03905 (rank : 86)
Query Neighborhood Hits	96	Target Neighborhood Hits	68	Shared Neighborhood Hits	50
SwissProt Accessions	O15165, O15166, O15167, O15168, Q6NXP3	Gene names	C18orf1
Domain Architecture
Description	Protein C18orf1.

CO8A_MOUSE
NC score	0.145834 (rank : 65)	θ value	8.99809 (rank : 95)
Query Neighborhood Hits	96	Target Neighborhood Hits	182	Shared Neighborhood Hits	61
SwissProt Accessions	Q8K182, Q8CHJ9, Q8CHK1	Gene names	C8a
Domain Architecture	No domain graphic available
Description	Complement component C8 alpha chain precursor (Complement component 8 subunit alpha).

TMPS6_MOUSE
NC score	0.144554 (rank : 66)	θ value	0.21417 (rank : 66)
Query Neighborhood Hits	96	Target Neighborhood Hits	341	Shared Neighborhood Hits	66
SwissProt Accessions	Q9DBI0, Q6PF94	Gene names	Tmprss6
Domain Architecture
Description	Transmembrane protease, serine 6 (EC 3.4.21.-) (Matriptase-2).

CR001_MOUSE
NC score	0.144166 (rank : 67)	θ value	4.03905 (rank : 87)
Query Neighborhood Hits	96	Target Neighborhood Hits	67	Shared Neighborhood Hits	50
SwissProt Accessions	Q8BWJ4	Gene names	D18Ertd653e
Domain Architecture	No domain graphic available
Description	Protein C18orf1 homolog.

CO8A_HUMAN
NC score	0.142517 (rank : 68)	θ value	θ > 10 (rank : 115)
Query Neighborhood Hits	96	Target Neighborhood Hits	200	Shared Neighborhood Hits	60
SwissProt Accessions	P07357, Q13668, Q9H130	Gene names	C8A
Domain Architecture
Description	Complement component C8 alpha chain precursor (Complement component 8 subunit alpha).

CFAI_MOUSE
NC score	0.141132 (rank : 69)	θ value	0.163984 (rank : 62)
Query Neighborhood Hits	96	Target Neighborhood Hits	290	Shared Neighborhood Hits	63
SwissProt Accessions	Q61129, Q9WU07	Gene names	Cfi, If
Domain Architecture
Description	Complement factor I precursor (EC 3.4.21.45) (C3B/C4B inactivator) [Contains: Complement factor I heavy chain; Complement factor I light chain].

PGBM_MOUSE
NC score	0.139380 (rank : 70)	θ value	0.163984 (rank : 64)
Query Neighborhood Hits	96	Target Neighborhood Hits	1073	Shared Neighborhood Hits	71
SwissProt Accessions	Q05793	Gene names	Hspg2
Domain Architecture
Description	Basement membrane-specific heparan sulfate proteoglycan core protein precursor (HSPG) (Perlecan) (PLC).

PGBM_HUMAN
NC score	0.135869 (rank : 71)	θ value	0.0193708 (rank : 51)
Query Neighborhood Hits	96	Target Neighborhood Hits	1113	Shared Neighborhood Hits	69
SwissProt Accessions	P98160, Q16287, Q9H3V5	Gene names	HSPG2
Domain Architecture
Description	Basement membrane-specific heparan sulfate proteoglycan core protein precursor (HSPG) (Perlecan) (PLC).

NID1_MOUSE
NC score	0.135219 (rank : 72)	θ value	θ > 10 (rank : 219)
Query Neighborhood Hits	96	Target Neighborhood Hits	335	Shared Neighborhood Hits	29
SwissProt Accessions	P10493, Q8BQI3, Q8C3U8, Q8C9P6	Gene names	Nid1, Ent
Domain Architecture
Description	Nidogen-1 precursor (Entactin).

MANS1_MOUSE
NC score	0.134600 (rank : 73)	θ value	0.0563607 (rank : 57)
Query Neighborhood Hits	96	Target Neighborhood Hits	19	Shared Neighborhood Hits	4
SwissProt Accessions	Q9CR33, Q80V71	Gene names	Mansc1
Domain Architecture	No domain graphic available
Description	MANSC domain-containing protein 1 precursor.

NID1_HUMAN
NC score	0.134050 (rank : 74)	θ value	θ > 10 (rank : 218)
Query Neighborhood Hits	96	Target Neighborhood Hits	329	Shared Neighborhood Hits	28
SwissProt Accessions	P14543, Q14942, Q59FL2, Q5TAF2, Q5TAF3, Q86XD7	Gene names	NID1, NID
Domain Architecture
Description	Nidogen-1 precursor (Entactin).

ENTK_MOUSE
NC score	0.133064 (rank : 75)	θ value	0.00509761 (rank : 46)
Query Neighborhood Hits	96	Target Neighborhood Hits	338	Shared Neighborhood Hits	63
SwissProt Accessions	P97435	Gene names	Prss7, Entk
Domain Architecture
Description	Enteropeptidase (EC 3.4.21.9) (Enterokinase) [Contains: Enteropeptidase non-catalytic heavy chain; Enteropeptidase catalytic light chain].

CO8B_HUMAN
NC score	0.132984 (rank : 76)	θ value	5.27518 (rank : 92)
Query Neighborhood Hits	96	Target Neighborhood Hits	199	Shared Neighborhood Hits	60
SwissProt Accessions	P07358	Gene names	C8B
Domain Architecture
Description	Complement component C8 beta chain precursor (Complement component 8 subunit beta).

CO8B_MOUSE
NC score	0.132319 (rank : 77)	θ value	3.0926 (rank : 83)
Query Neighborhood Hits	96	Target Neighborhood Hits	224	Shared Neighborhood Hits	61
SwissProt Accessions	Q8BH35, Q4VAH1, Q8CHJ5, Q8CHJ6, Q8VC14	Gene names	C8b
Domain Architecture	No domain graphic available
Description	Complement component C8 beta chain precursor (Complement component 8 subunit beta).

APLP2_MOUSE
NC score	0.129747 (rank : 78)	θ value	θ > 10 (rank : 101)
Query Neighborhood Hits	96	Target Neighborhood Hits	186	Shared Neighborhood Hits	3
SwissProt Accessions	Q06335	Gene names	Aplp2
Domain Architecture
Description	Amyloid-like protein 2 precursor (CDEI box-binding protein) (CDEBP).

ENTK_HUMAN
NC score	0.129139 (rank : 79)	θ value	0.0193708 (rank : 49)
Query Neighborhood Hits	96	Target Neighborhood Hits	310	Shared Neighborhood Hits	61
SwissProt Accessions	P98073	Gene names	PRSS7, ENTK
Domain Architecture
Description	Enteropeptidase precursor (EC 3.4.21.9) (Enterokinase) [Contains: Enteropeptidase non-catalytic heavy chain; Enteropeptidase catalytic light chain].

K0319_HUMAN
NC score	0.127391 (rank : 80)	θ value	0.813845 (rank : 72)
Query Neighborhood Hits	96	Target Neighborhood Hits	154	Shared Neighborhood Hits	10
SwissProt Accessions	Q5VV43, Q9UJC8, Q9Y4G7	Gene names	KIAA0319
Domain Architecture	No domain graphic available
Description	Protein KIAA0319 precursor.

NID2_MOUSE
NC score	0.127217 (rank : 81)	θ value	θ > 10 (rank : 221)
Query Neighborhood Hits	96	Target Neighborhood Hits	338	Shared Neighborhood Hits	30
SwissProt Accessions	O88322	Gene names	Nid2
Domain Architecture
Description	Nidogen-2 precursor (NID-2) (Entactin-2).

NID2_HUMAN
NC score	0.125641 (rank : 82)	θ value	θ > 10 (rank : 220)
Query Neighborhood Hits	96	Target Neighborhood Hits	456	Shared Neighborhood Hits	28
SwissProt Accessions	Q14112, O43710	Gene names	NID2
Domain Architecture
Description	Nidogen-2 precursor (NID-2) (Osteonidogen).

MANS1_HUMAN
NC score	0.125039 (rank : 83)	θ value	0.0431538 (rank : 54)
Query Neighborhood Hits	96	Target Neighborhood Hits	44	Shared Neighborhood Hits	5
SwissProt Accessions	Q9H8J5, Q8NEC1	Gene names	MANSC1
Domain Architecture	No domain graphic available
Description	MANSC domain-containing protein 1 precursor.

CO7_HUMAN
NC score	0.123106 (rank : 84)	θ value	2.36792 (rank : 81)
Query Neighborhood Hits	96	Target Neighborhood Hits	278	Shared Neighborhood Hits	56
SwissProt Accessions	P10643, Q6P3T5, Q92489	Gene names	C7
Domain Architecture
Description	Complement component C7 precursor.

TMPS9_HUMAN
NC score	0.121031 (rank : 85)	θ value	0.000602161 (rank : 37)
Query Neighborhood Hits	96	Target Neighborhood Hits	276	Shared Neighborhood Hits	61
SwissProt Accessions	Q7Z410, Q6ZND6, Q7Z411	Gene names	TMPRSS9
Domain Architecture	No domain graphic available
Description	Transmembrane protease, serine 9 (EC 3.4.21.-) (Polyserase-1) (Polyserase-I) (Polyserine protease 1) [Contains: Serase-1; Serase-2; Serase-3].

K0319_MOUSE
NC score	0.117088 (rank : 86)	θ value	2.36792 (rank : 82)
Query Neighborhood Hits	96	Target Neighborhood Hits	134	Shared Neighborhood Hits	8
SwissProt Accessions	Q5SZV5, Q80U39	Gene names	Kiaa0319
Domain Architecture	No domain graphic available
Description	Protein KIAA0319 precursor.

TMPS9_MOUSE
NC score	0.115274 (rank : 87)	θ value	0.00298849 (rank : 44)
Query Neighborhood Hits	96	Target Neighborhood Hits	296	Shared Neighborhood Hits	56
SwissProt Accessions	P69525	Gene names	Tmprss9
Domain Architecture	No domain graphic available
Description	Transmembrane protease, serine 9 (EC 3.4.21.-) (Polyserase-1) (Polyserine protease 1) (Polyserase-I) [Contains: Serase-1; Serase-2; Serase-3].

GLU2B_HUMAN
NC score	0.112034 (rank : 88)	θ value	θ > 10 (rank : 163)
Query Neighborhood Hits	96	Target Neighborhood Hits	377	Shared Neighborhood Hits	40
SwissProt Accessions	P14314, Q96BU9, Q96D06, Q9P0W9	Gene names	PRKCSH, G19P1
Domain Architecture	No domain graphic available
Description	Glucosidase 2 subunit beta precursor (Glucosidase II subunit beta) (Protein kinase C substrate, 60.1 kDa protein, heavy chain) (PKCSH) (80K-H protein).

APLP1_HUMAN
NC score	0.109135 (rank : 89)	θ value	θ > 10 (rank : 99)
Query Neighborhood Hits	96	Target Neighborhood Hits	85	Shared Neighborhood Hits	3
SwissProt Accessions	P51693, O00113, Q96A92	Gene names	APLP1
Domain Architecture
Description	Amyloid-like protein 1 precursor (APLP) (APLP-1) [Contains: C30].

APLP1_MOUSE
NC score	0.108860 (rank : 90)	θ value	θ > 10 (rank : 100)
Query Neighborhood Hits	96	Target Neighborhood Hits	130	Shared Neighborhood Hits	3
SwissProt Accessions	Q03157, Q8VC38	Gene names	Aplp1
Domain Architecture
Description	Amyloid-like protein 1 precursor (APLP) (APLP-1) [Contains: C30].

GLU2B_MOUSE
NC score	0.104048 (rank : 91)	θ value	θ > 10 (rank : 164)
Query Neighborhood Hits	96	Target Neighborhood Hits	357	Shared Neighborhood Hits	39
SwissProt Accessions	O08795, Q921X2	Gene names	Prkcsh
Domain Architecture	No domain graphic available
Description	Glucosidase 2 subunit beta precursor (Glucosidase II subunit beta) (Protein kinase C substrate, 60.1 kDa protein, heavy chain) (PKCSH) (80K-H protein).

CO7A1_HUMAN
NC score	0.100525 (rank : 92)	θ value	0.00228821 (rank : 42)
Query Neighborhood Hits	96	Target Neighborhood Hits	807	Shared Neighborhood Hits	25
SwissProt Accessions	Q02388, Q14054, Q16507	Gene names	COL7A1
Domain Architecture
Description	Collagen alpha-1(VII) chain precursor (Long-chain collagen) (LC collagen).

TMPS2_MOUSE
NC score	0.097735 (rank : 93)	θ value	1.06291 (rank : 76)
Query Neighborhood Hits	96	Target Neighborhood Hits	243	Shared Neighborhood Hits	57
SwissProt Accessions	Q9JIQ8, Q9JKC4, Q9QY82	Gene names	Tmprss2
Domain Architecture
Description	Transmembrane protease, serine 2 (EC 3.4.21.-) (Epitheliasin) (Plasmic transmembrane protein X) [Contains: Transmembrane protease, serine 2 non-catalytic chain; Transmembrane protease, serine 2 catalytic chain].

GRN_HUMAN
NC score	0.094302 (rank : 94)	θ value	θ > 10 (rank : 165)
Query Neighborhood Hits	96	Target Neighborhood Hits	268	Shared Neighborhood Hits	34
SwissProt Accessions	P28799, P23781, P23782, P23783, P23784, Q9BWE7, Q9UCH0	Gene names	GRN
Domain Architecture
Description	Granulins precursor (Proepithelin) (PEPI) [Contains: Acrogranin; Paragranulin; Granulin-1 (Granulin G); Granulin-2 (Granulin F); Granulin-3 (Granulin B); Granulin-4 (Granulin A); Granulin-5 (Granulin C); Granulin-6 (Granulin D); Granulin-7 (Granulin E)].

NETO2_MOUSE
NC score	0.089745 (rank : 95)	θ value	θ > 10 (rank : 215)
Query Neighborhood Hits	96	Target Neighborhood Hits	113	Shared Neighborhood Hits	46
SwissProt Accessions	Q8BNJ6, Q5VM49, Q8C4Q8	Gene names	Neto2, Btcl2
Domain Architecture	No domain graphic available
Description	Neuropilin and tolloid-like protein 2 precursor (Brain-specific transmembrane protein containing 2 CUB and 1 LDL-receptor class A domains protein 2).

NETO2_HUMAN
NC score	0.089556 (rank : 96)	θ value	θ > 10 (rank : 214)
Query Neighborhood Hits	96	Target Neighborhood Hits	109	Shared Neighborhood Hits	46
SwissProt Accessions	Q8NC67, Q7Z381, Q8ND51, Q96SP4, Q9NVY8	Gene names	NETO2, BTCL2
Domain Architecture	No domain graphic available
Description	Neuropilin and tolloid-like protein 2 precursor (Brain-specific transmembrane protein containing 2 CUB and 1 LDL-receptor class A domains protein 2).

FBN1_MOUSE
NC score	0.087750 (rank : 97)	θ value	0.0563607 (rank : 56)
Query Neighborhood Hits	96	Target Neighborhood Hits	563	Shared Neighborhood Hits	43
SwissProt Accessions	Q61554, Q60826	Gene names	Fbn1, Fbn-1
Domain Architecture
Description	Fibrillin-1 precursor.

SCUB3_HUMAN
NC score	0.086907 (rank : 98)	θ value	θ > 10 (rank : 240)
Query Neighborhood Hits	96	Target Neighborhood Hits	428	Shared Neighborhood Hits	41
SwissProt Accessions	Q8IX30, Q5CZB3, Q86UZ9, Q8NAU9	Gene names	SCUBE3, CEGF3
Domain Architecture	No domain graphic available
Description	Signal peptide, CUB and EGF-like domain-containing protein 3 precursor.

TMPS3_HUMAN
NC score	0.086611 (rank : 99)	θ value	4.03905 (rank : 90)
Query Neighborhood Hits	96	Target Neighborhood Hits	245	Shared Neighborhood Hits	59
SwissProt Accessions	P57727, Q6ZMC3	Gene names	TMPRSS3, ECHOS1, TADG12
Domain Architecture
Description	Transmembrane protease, serine 3 (EC 3.4.21.-) (Serine protease TADG- 12) (Tumor-associated differentially-expressed gene 12 protein).

SCUB3_MOUSE
NC score	0.086391 (rank : 100)	θ value	θ > 10 (rank : 241)
Query Neighborhood Hits	96	Target Neighborhood Hits	442	Shared Neighborhood Hits	41
SwissProt Accessions	Q66PY1, Q68FG9	Gene names	Scube3
Domain Architecture	No domain graphic available
Description	Signal peptide, CUB and EGF-like domain-containing protein 3 precursor.

ZAN_MOUSE
NC score	0.084788 (rank : 101)	θ value	1.06291 (rank : 77)
Query Neighborhood Hits	96	Target Neighborhood Hits	808	Shared Neighborhood Hits	39
SwissProt Accessions	O88799, O08647	Gene names	Zan
Domain Architecture
Description	Zonadhesin precursor.

FBN1_HUMAN
NC score	0.084423 (rank : 102)	θ value	0.21417 (rank : 65)
Query Neighborhood Hits	96	Target Neighborhood Hits	557	Shared Neighborhood Hits	37
SwissProt Accessions	P35555, Q15972, Q75N87	Gene names	FBN1, FBN
Domain Architecture
Description	Fibrillin-1 precursor.

NETO1_HUMAN
NC score	0.084363 (rank : 103)	θ value	θ > 10 (rank : 212)
Query Neighborhood Hits	96	Target Neighborhood Hits	110	Shared Neighborhood Hits	49
SwissProt Accessions	Q8TDF5, Q86W85, Q8ND78, Q8TDF4	Gene names	NETO1, BTCL1
Domain Architecture	No domain graphic available
Description	Neuropilin and tolloid-like protein 1 precursor (Brain-specific transmembrane protein containing 2 CUB and 1 LDL-receptor class A domains protein 1).

NETO1_MOUSE
NC score	0.084340 (rank : 104)	θ value	θ > 10 (rank : 213)
Query Neighborhood Hits	96	Target Neighborhood Hits	109	Shared Neighborhood Hits	49
SwissProt Accessions	Q8R4I7, Q80X39, Q8C4S3, Q8CCM2	Gene names	Neto1, Btcl1
Domain Architecture	No domain graphic available
Description	Neuropilin and tolloid-like protein 1 precursor (Brain-specific transmembrane protein containing 2 CUB and 1 LDL-receptor class A domains protein 1).

TMPS2_HUMAN
NC score	0.081525 (rank : 105)	θ value	θ > 10 (rank : 263)
Query Neighborhood Hits	96	Target Neighborhood Hits	252	Shared Neighborhood Hits	48
SwissProt Accessions	O15393, Q9BXX1	Gene names	TMPRSS2, PRSS10
Domain Architecture
Description	Transmembrane protease, serine 2 precursor (EC 3.4.21.-) [Contains: Transmembrane protease, serine 2 non-catalytic chain; Transmembrane protease, serine 2 catalytic chain].

CD248_HUMAN
NC score	0.079740 (rank : 106)	θ value	θ > 10 (rank : 112)
Query Neighborhood Hits	96	Target Neighborhood Hits	679	Shared Neighborhood Hits	28
SwissProt Accessions	Q9HCU0, Q3SX55, Q96KB6	Gene names	CD248, CD164L1, TEM1
Domain Architecture	No domain graphic available
Description	Endosialin precursor (Tumor endothelial marker 1) (CD248 antigen).

MATN2_HUMAN
NC score	0.079570 (rank : 107)	θ value	θ > 10 (rank : 201)
Query Neighborhood Hits	96	Target Neighborhood Hits	365	Shared Neighborhood Hits	33
SwissProt Accessions	O00339, Q6UWA5, Q7Z5X1, Q8NDE6, Q96FT5, Q9NSZ1	Gene names	MATN2
Domain Architecture
Description	Matrilin-2 precursor.

CD248_MOUSE
NC score	0.078959 (rank : 108)	θ value	θ > 10 (rank : 113)
Query Neighborhood Hits	96	Target Neighborhood Hits	578	Shared Neighborhood Hits	28
SwissProt Accessions	Q91V98, Q3UMV6, Q91ZV1	Gene names	Cd248, Tem1
Domain Architecture	No domain graphic available
Description	Endosialin precursor (Tumor endothelial marker 1) (CD248 antigen).

PROZ_HUMAN
NC score	0.078436 (rank : 109)	θ value	θ > 10 (rank : 233)
Query Neighborhood Hits	96	Target Neighborhood Hits	422	Shared Neighborhood Hits	42
SwissProt Accessions	P22891, Q15213	Gene names	PROZ
Domain Architecture
Description	Vitamin K-dependent protein Z precursor.

WFD15_MOUSE
NC score	0.077662 (rank : 110)	θ value	θ > 10 (rank : 288)
Query Neighborhood Hits	96	Target Neighborhood Hits	17	Shared Neighborhood Hits	4
SwissProt Accessions	Q9JHY4, Q8BVC0	Gene names	Wfdc15, Swam1
Domain Architecture
Description	WAP four-disulfide core domain protein 15 precursor (Single WAP motif protein 1) (Elafin-like protein I).

FBN2_HUMAN
NC score	0.077346 (rank : 111)	θ value	θ > 10 (rank : 158)
Query Neighborhood Hits	96	Target Neighborhood Hits	560	Shared Neighborhood Hits	38
SwissProt Accessions	P35556	Gene names	FBN2
Domain Architecture
Description	Fibrillin-2 precursor.

FBN2_MOUSE
NC score	0.077345 (rank : 112)	θ value	θ > 10 (rank : 159)
Query Neighborhood Hits	96	Target Neighborhood Hits	549	Shared Neighborhood Hits	39
SwissProt Accessions	Q61555, Q63957	Gene names	Fbn2, Fbn-2
Domain Architecture
Description	Fibrillin-2 precursor.

FBN3_HUMAN
NC score	0.077261 (rank : 113)	θ value	θ > 10 (rank : 160)
Query Neighborhood Hits	96	Target Neighborhood Hits	543	Shared Neighborhood Hits	35
SwissProt Accessions	Q75N90, Q75N91, Q75N92, Q75N93, Q86SJ5, Q96JP8	Gene names	FBN3, KIAA1776
Domain Architecture	No domain graphic available
Description	Fibrillin-3 precursor.

MATN4_MOUSE
NC score	0.075988 (rank : 114)	θ value	θ > 10 (rank : 206)
Query Neighborhood Hits	96	Target Neighborhood Hits	277	Shared Neighborhood Hits	31
SwissProt Accessions	O89029, O89030, Q9QWS3	Gene names	Matn4
Domain Architecture
Description	Matrilin-4 precursor (MAT-4).

TMPS3_MOUSE
NC score	0.075796 (rank : 115)	θ value	θ > 10 (rank : 264)
Query Neighborhood Hits	96	Target Neighborhood Hits	239	Shared Neighborhood Hits	53
SwissProt Accessions	Q8K1T0, Q8VDE0	Gene names	Tmprss3
Domain Architecture
Description	Transmembrane protease, serine 3 (EC 3.4.21.-).

FBLN1_MOUSE
NC score	0.075567 (rank : 116)	θ value	θ > 10 (rank : 149)
Query Neighborhood Hits	96	Target Neighborhood Hits	329	Shared Neighborhood Hits	33
SwissProt Accessions	Q08879, Q08878, Q8C3B1, Q91ZC9, Q922K8	Gene names	Fbln1
Domain Architecture
Description	Fibulin-1 precursor (Basement-membrane protein 90) (BM-90).

TRBM_MOUSE
NC score	0.075499 (rank : 117)	θ value	θ > 10 (rank : 275)
Query Neighborhood Hits	96	Target Neighborhood Hits	361	Shared Neighborhood Hits	32
SwissProt Accessions	P15306	Gene names	Thbd
Domain Architecture
Description	Thrombomodulin precursor (TM) (Fetomodulin) (CD141 antigen).

GAS6_MOUSE
NC score	0.075277 (rank : 118)	θ value	θ > 10 (rank : 162)
Query Neighborhood Hits	96	Target Neighborhood Hits	343	Shared Neighborhood Hits	29
SwissProt Accessions	Q61592, Q99K57	Gene names	Gas6
Domain Architecture
Description	Growth-arrest-specific protein 6 precursor (GAS-6).

MATN4_HUMAN
NC score	0.075225 (rank : 119)	θ value	θ > 10 (rank : 205)
Query Neighborhood Hits	96	Target Neighborhood Hits	287	Shared Neighborhood Hits	30
SwissProt Accessions	O95460, Q5QPU2, Q5QPU3, Q5QPU4, Q8N2M5, Q8N2M7, Q9H1F8, Q9H1F9	Gene names	MATN4
Domain Architecture
Description	Matrilin-4 precursor.

MATN3_HUMAN
NC score	0.075112 (rank : 120)	θ value	θ > 10 (rank : 203)
Query Neighborhood Hits	96	Target Neighborhood Hits	268	Shared Neighborhood Hits	26
SwissProt Accessions	O15232	Gene names	MATN3
Domain Architecture
Description	Matrilin-3 precursor.

GAS6_HUMAN
NC score	0.074674 (rank : 121)	θ value	θ > 10 (rank : 161)
Query Neighborhood Hits	96	Target Neighborhood Hits	348	Shared Neighborhood Hits	34
SwissProt Accessions	Q14393, Q7Z7N3	Gene names	GAS6
Domain Architecture
Description	Growth-arrest-specific protein 6 precursor (GAS-6).

LTB1L_HUMAN
NC score	0.074620 (rank : 122)	θ value	θ > 10 (rank : 186)
Query Neighborhood Hits	96	Target Neighborhood Hits	553	Shared Neighborhood Hits	40
SwissProt Accessions	Q14766	Gene names	LTBP1
Domain Architecture
Description	Latent-transforming growth factor beta-binding protein, isoform 1L precursor (LTBP-1) (Transforming growth factor beta-1-binding protein 1) (TGF-beta1-BP-1).

TENA_HUMAN
NC score	0.074041 (rank : 123)	θ value	θ > 10 (rank : 248)
Query Neighborhood Hits	96	Target Neighborhood Hits	631	Shared Neighborhood Hits	42
SwissProt Accessions	P24821, Q14583, Q15567	Gene names	TNC, HXB
Domain Architecture
Description	Tenascin precursor (TN) (Tenascin-C) (TN-C) (Hexabrachion) (Cytotactin) (Neuronectin) (GMEM) (JI) (Myotendinous antigen) (Glioma- associated-extracellular matrix antigen) (GP 150-225).

LTB1S_HUMAN
NC score	0.073955 (rank : 124)	θ value	θ > 10 (rank : 188)
Query Neighborhood Hits	96	Target Neighborhood Hits	502	Shared Neighborhood Hits	37
SwissProt Accessions	P22064, Q8TD95	Gene names	LTBP1
Domain Architecture
Description	Latent-transforming growth factor beta-binding protein, isoform 1S precursor (LTBP-1) (Transforming growth factor beta-1-binding protein 1) (TGF-beta1-BP-1).

PROC_MOUSE
NC score	0.073892 (rank : 125)	θ value	θ > 10 (rank : 230)
Query Neighborhood Hits	96	Target Neighborhood Hits	426	Shared Neighborhood Hits	41
SwissProt Accessions	P33587, O35498, Q91WN8, Q99PC6	Gene names	Proc
Domain Architecture
Description	Vitamin K-dependent protein C precursor (EC 3.4.21.69) (Autoprothrombin IIA) (Anticoagulant protein C) (Blood coagulation factor XIV) [Contains: Vitamin K-dependent protein C light chain; Vitamin K-dependent protein C heavy chain; Activation peptide].

MATN3_MOUSE
NC score	0.073716 (rank : 126)	θ value	θ > 10 (rank : 204)
Query Neighborhood Hits	96	Target Neighborhood Hits	261	Shared Neighborhood Hits	25
SwissProt Accessions	O35701, Q9JHM0	Gene names	Matn3
Domain Architecture
Description	Matrilin-3 precursor.

MATN2_MOUSE
NC score	0.073336 (rank : 127)	θ value	θ > 10 (rank : 202)
Query Neighborhood Hits	96	Target Neighborhood Hits	356	Shared Neighborhood Hits	31
SwissProt Accessions	O08746	Gene names	Matn2
Domain Architecture
Description	Matrilin-2 precursor.

FBLN2_HUMAN
NC score	0.073317 (rank : 128)	θ value	θ > 10 (rank : 150)
Query Neighborhood Hits	96	Target Neighborhood Hits	392	Shared Neighborhood Hits	34
SwissProt Accessions	P98095	Gene names	FBLN2
Domain Architecture
Description	Fibulin-2 precursor.

TRBM_HUMAN
NC score	0.073257 (rank : 129)	θ value	θ > 10 (rank : 274)
Query Neighborhood Hits	96	Target Neighborhood Hits	339	Shared Neighborhood Hits	32
SwissProt Accessions	P07204, Q9UC32	Gene names	THBD, THRM
Domain Architecture
Description	Thrombomodulin precursor (TM) (Fetomodulin) (CD141 antigen).

FBLN2_MOUSE
NC score	0.073182 (rank : 130)	θ value	θ > 10 (rank : 151)
Query Neighborhood Hits	96	Target Neighborhood Hits	505	Shared Neighborhood Hits	35
SwissProt Accessions	P37889, Q9WUI2	Gene names	Fbln2
Domain Architecture
Description	Fibulin-2 precursor.

PROS_HUMAN
NC score	0.073179 (rank : 131)	θ value	θ > 10 (rank : 231)
Query Neighborhood Hits	96	Target Neighborhood Hits	340	Shared Neighborhood Hits	33
SwissProt Accessions	P07225, Q15518, Q7Z715	Gene names	PROS1, PROS
Domain Architecture
Description	Vitamin K-dependent protein S precursor.

TENA_MOUSE
NC score	0.073119 (rank : 132)	θ value	θ > 10 (rank : 249)
Query Neighborhood Hits	96	Target Neighborhood Hits	596	Shared Neighborhood Hits	45
SwissProt Accessions	Q80YX1, Q64706, Q80YX2	Gene names	Tnc, Hxb
Domain Architecture	No domain graphic available
Description	Tenascin precursor (TN) (Tenascin-C) (TN-C) (Hexabrachion).

GRN_MOUSE
NC score	0.072496 (rank : 133)	θ value	θ > 10 (rank : 166)
Query Neighborhood Hits	96	Target Neighborhood Hits	248	Shared Neighborhood Hits	28
SwissProt Accessions	P28798	Gene names	Grn
Domain Architecture
Description	Granulins precursor (Proepithelin) (PEPI) (PC cell-derived growth factor) (PCDGF) [Contains: Acrogranin; Granulin-1; Granulin-2; Granulin-3; Granulin-4; Granulin-5; Granulin-6; Granulin-7].

C1QR1_HUMAN
NC score	0.072173 (rank : 134)	θ value	θ > 10 (rank : 106)
Query Neighborhood Hits	96	Target Neighborhood Hits	493	Shared Neighborhood Hits	32
SwissProt Accessions	Q9NPY3, O00274	Gene names	CD93, C1QR1, MXRA4
Domain Architecture
Description	Complement component C1q receptor precursor (Complement component 1 q subcomponent receptor 1) (C1qR) (C1qRp) (C1qR(p)) (C1q/MBL/SPA receptor) (CD93 antigen) (CDw93).

FBLN1_HUMAN
NC score	0.072139 (rank : 135)	θ value	θ > 10 (rank : 148)
Query Neighborhood Hits	96	Target Neighborhood Hits	324	Shared Neighborhood Hits	33
SwissProt Accessions	P23142, P23143, P23144, P37888, Q5TIC4, Q8TBH8, Q9HBQ5, Q9UC21, Q9UGR4, Q9UH41	Gene names	FBLN1
Domain Architecture
Description	Fibulin-1 precursor.

PROS_MOUSE
NC score	0.070981 (rank : 136)	θ value	θ > 10 (rank : 232)
Query Neighborhood Hits	96	Target Neighborhood Hits	330	Shared Neighborhood Hits	29
SwissProt Accessions	Q08761, P43483	Gene names	Pros1, Pros
Domain Architecture
Description	Vitamin K-dependent protein S precursor.

FA9_HUMAN
NC score	0.070822 (rank : 137)	θ value	θ > 10 (rank : 147)
Query Neighborhood Hits	96	Target Neighborhood Hits	421	Shared Neighborhood Hits	45
SwissProt Accessions	P00740	Gene names	F9
Domain Architecture
Description	Coagulation factor IX precursor (EC 3.4.21.22) (Christmas factor) (Plasma thromboplastin component) (PTC) [Contains: Coagulation factor IXa light chain; Coagulation factor IXa heavy chain].

LTBP2_HUMAN
NC score	0.070706 (rank : 138)	θ value	θ > 10 (rank : 190)
Query Neighborhood Hits	96	Target Neighborhood Hits	552	Shared Neighborhood Hits	36
SwissProt Accessions	Q14767, Q99907, Q9NS51	Gene names	LTBP2
Domain Architecture
Description	Latent-transforming growth factor beta-binding protein 2 precursor (LTBP-2).

PROC_HUMAN
NC score	0.070693 (rank : 139)	θ value	θ > 10 (rank : 229)
Query Neighborhood Hits	96	Target Neighborhood Hits	406	Shared Neighborhood Hits	39
SwissProt Accessions	P04070, Q15189, Q15190, Q16001	Gene names	PROC
Domain Architecture
Description	Vitamin K-dependent protein C precursor (EC 3.4.21.69) (Autoprothrombin IIA) (Anticoagulant protein C) (Blood coagulation factor XIV) [Contains: Vitamin K-dependent protein C light chain; Vitamin K-dependent protein C heavy chain; Activation peptide].

FA10_MOUSE
NC score	0.070592 (rank : 140)	θ value	θ > 10 (rank : 141)
Query Neighborhood Hits	96	Target Neighborhood Hits	435	Shared Neighborhood Hits	44
SwissProt Accessions	O88947, O54740, Q99L32	Gene names	F10
Domain Architecture
Description	Coagulation factor X precursor (EC 3.4.21.6) (Stuart factor) [Contains: Factor X light chain; Factor X heavy chain; Activated factor Xa heavy chain].

LTB1L_MOUSE
NC score	0.069965 (rank : 141)	θ value	θ > 10 (rank : 187)
Query Neighborhood Hits	96	Target Neighborhood Hits	514	Shared Neighborhood Hits	39
SwissProt Accessions	Q8CG19, O88349, Q8BNW7, Q8C7F5, Q8CIR0	Gene names	Ltbp1
Domain Architecture
Description	Latent-transforming growth factor beta-binding protein, isoform 1L precursor (LTBP-1) (Transforming growth factor beta-1-binding protein 1) (TGF-beta1-BP-1).

MASP1_HUMAN
NC score	0.069957 (rank : 142)	θ value	θ > 10 (rank : 195)
Query Neighborhood Hits	96	Target Neighborhood Hits	369	Shared Neighborhood Hits	40
SwissProt Accessions	P48740, O95570, Q9UF09	Gene names	MASP1, CRARF, CRARF1, PRSS5
Domain Architecture
Description	Complement-activating component of Ra-reactive factor precursor (EC 3.4.21.-) (Ra-reactive factor serine protease p100) (RaRF) (Mannan-binding lectin serine protease 1) (Mannose-binding protein- associated serine protease) (MASP-1) [Contains: Complement-activating component of Ra-reactive factor heavy chain; Complement-activating component of Ra-reactive factor light chain].

LTB1S_MOUSE
NC score	0.069852 (rank : 143)	θ value	θ > 10 (rank : 189)
Query Neighborhood Hits	96	Target Neighborhood Hits	479	Shared Neighborhood Hits	36
SwissProt Accessions	Q8CG18, Q8BNW7, Q8C7F5, Q8CIR0	Gene names	Ltbp1
Domain Architecture
Description	Latent-transforming growth factor beta-binding protein, isoform 1S precursor (LTBP-1) (Transforming growth factor beta-1-binding protein 1) (TGF-beta1-BP-1).

FA10_HUMAN
NC score	0.069361 (rank : 144)	θ value	θ > 10 (rank : 140)
Query Neighborhood Hits	96	Target Neighborhood Hits	431	Shared Neighborhood Hits	44
SwissProt Accessions	P00742, Q14340	Gene names	F10
Domain Architecture
Description	Coagulation factor X precursor (EC 3.4.21.6) (Stuart factor) (Stuart- Prower factor) [Contains: Factor X light chain; Factor X heavy chain; Activated factor Xa heavy chain].

MASP2_HUMAN
NC score	0.069257 (rank : 145)	θ value	θ > 10 (rank : 197)
Query Neighborhood Hits	96	Target Neighborhood Hits	364	Shared Neighborhood Hits	40
SwissProt Accessions	O00187, O75754, Q5TEQ5, Q5TER0, Q96QG4, Q9BZH0, Q9H498, Q9H499, Q9UBP3, Q9ULC7, Q9UMV3, Q9Y270	Gene names	MASP2
Domain Architecture
Description	Mannan-binding lectin serine protease 2 precursor (EC 3.4.21.104) (Mannose-binding protein-associated serine protease 2) (MASP-2) (MBL- associated serine protease 2) [Contains: Mannan-binding lectin serine protease 2 A chain; Mannan-binding lectin serine protease 2 B chain].

C1R_HUMAN
NC score	0.069167 (rank : 146)	θ value	θ > 10 (rank : 110)
Query Neighborhood Hits	96	Target Neighborhood Hits	364	Shared Neighborhood Hits	40
SwissProt Accessions	P00736, Q8J012	Gene names	C1R
Domain Architecture
Description	Complement C1r subcomponent precursor (EC 3.4.21.41) (Complement component 1, r subcomponent) [Contains: Complement C1r subcomponent heavy chain; Complement C1r subcomponent light chain].

PROZ_MOUSE
NC score	0.068815 (rank : 147)	θ value	θ > 10 (rank : 234)
Query Neighborhood Hits	96	Target Neighborhood Hits	410	Shared Neighborhood Hits	37
SwissProt Accessions	Q9CQW3	Gene names	Proz
Domain Architecture
Description	Vitamin K-dependent protein Z precursor.

C1RA_MOUSE
NC score	0.068815 (rank : 148)	θ value	θ > 10 (rank : 108)
Query Neighborhood Hits	96	Target Neighborhood Hits	379	Shared Neighborhood Hits	41
SwissProt Accessions	Q8CG16, Q99KI6, Q9ET60	Gene names	C1ra, C1r
Domain Architecture
Description	Complement C1r-A subcomponent precursor (EC 3.4.21.41) (Complement component 1, r-A subcomponent) [Contains: Complement C1r-A subcomponent heavy chain; Complement C1r-A subcomponent light chain].

C1RB_MOUSE
NC score	0.068322 (rank : 149)	θ value	θ > 10 (rank : 109)
Query Neighborhood Hits	96	Target Neighborhood Hits	380	Shared Neighborhood Hits	40
SwissProt Accessions	Q8CFG9	Gene names	C1rb, C1r
Domain Architecture	No domain graphic available
Description	Complement C1r-B subcomponent precursor (EC 3.4.21.41) (Complement component 1, r-B subcomponent) [Contains: Complement C1r-B subcomponent heavy chain; Complement C1r-B subcomponent light chain].

MASP1_MOUSE
NC score	0.068227 (rank : 150)	θ value	θ > 10 (rank : 196)
Query Neighborhood Hits	96	Target Neighborhood Hits	364	Shared Neighborhood Hits	39
SwissProt Accessions	P98064	Gene names	Masp1, Crarf
Domain Architecture
Description	Complement-activating component of Ra-reactive factor precursor (EC 3.4.21.-) (Ra-reactive factor serine protease p100) (RaRF) (Mannan-binding lectin serine protease 1) [Contains: Complement- activating component of Ra-reactive factor heavy chain; Complement- activating component of Ra-reactive factor light chain].

FBLN5_HUMAN
NC score	0.067905 (rank : 151)	θ value	θ > 10 (rank : 156)
Query Neighborhood Hits	96	Target Neighborhood Hits	329	Shared Neighborhood Hits	32
SwissProt Accessions	Q9UBX5, O75966, Q6UWA3	Gene names	FBLN5, DANCE
Domain Architecture
Description	Fibulin-5 precursor (FIBL-5) (Developmental arteries and neural crest EGF-like protein) (Dance) (Urine p50 protein) (UP50).

C1QR1_MOUSE
NC score	0.067862 (rank : 152)	θ value	θ > 10 (rank : 107)
Query Neighborhood Hits	96	Target Neighborhood Hits	342	Shared Neighborhood Hits	28
SwissProt Accessions	O89103, Q3U2X0	Gene names	Cd93, Aa4, C1qr1, C1qrp, Ly68
Domain Architecture
Description	Complement component C1q receptor precursor (Complement component 1 q subcomponent receptor 1) (C1qRp) (C1qR(p)) (C1q/MBL/SPA receptor) (CD93 antigen) (Cell surface antigen AA4) (Lymphocyte antigen 68).

CUBN_MOUSE
NC score	0.067778 (rank : 153)	θ value	θ > 10 (rank : 127)
Query Neighborhood Hits	96	Target Neighborhood Hits	477	Shared Neighborhood Hits	46
SwissProt Accessions	Q9JLB4	Gene names	Cubn, Ifcr
Domain Architecture	No domain graphic available
Description	Cubilin precursor (Intrinsic factor-cobalamin receptor).

TLL1_MOUSE
NC score	0.067627 (rank : 154)	θ value	θ > 10 (rank : 256)
Query Neighborhood Hits	96	Target Neighborhood Hits	237	Shared Neighborhood Hits	36
SwissProt Accessions	Q62381, Q3UTT9, Q8BNP5	Gene names	Tll1, Tll
Domain Architecture	No domain graphic available
Description	Tolloid-like protein 1 precursor (EC 3.4.24.-) (mTll).

TLL1_HUMAN
NC score	0.067312 (rank : 155)	θ value	θ > 10 (rank : 255)
Query Neighborhood Hits	96	Target Neighborhood Hits	236	Shared Neighborhood Hits	34
SwissProt Accessions	O43897, Q96AN3, Q9NQS4	Gene names	TLL1, TLL
Domain Architecture	No domain graphic available
Description	Tolloid-like protein 1 precursor (EC 3.4.24.-).

MASP2_MOUSE
NC score	0.067130 (rank : 156)	θ value	θ > 10 (rank : 198)
Query Neighborhood Hits	96	Target Neighborhood Hits	382	Shared Neighborhood Hits	39
SwissProt Accessions	Q91WP0, Q9QXA4, Q9QXD2, Q9QXD5, Q9Z338	Gene names	Masp2
Domain Architecture	No domain graphic available
Description	Mannan-binding lectin serine protease 2 precursor (EC 3.4.21.104) (Mannose-binding protein-associated serine protease 2) (MASP-2) (MBL- associated serine protease 2) [Contains: Mannan-binding lectin serine protease 2 A chain; Mannan-binding lectin serine protease 2 B chain].

FBLN5_MOUSE
NC score	0.066982 (rank : 157)	θ value	θ > 10 (rank : 157)
Query Neighborhood Hits	96	Target Neighborhood Hits	317	Shared Neighborhood Hits	30
SwissProt Accessions	Q9WVH9, Q541Z7	Gene names	Fbln5, Dance
Domain Architecture
Description	Fibulin-5 precursor (FIBL-5) (Developmental arteries and neural crest EGF-like protein) (Dance).

LTBP4_MOUSE
NC score	0.066782 (rank : 158)	θ value	θ > 10 (rank : 194)
Query Neighborhood Hits	96	Target Neighborhood Hits	607	Shared Neighborhood Hits	38
SwissProt Accessions	Q8K4G1, Q8K4G0	Gene names	Ltbp4
Domain Architecture
Description	Latent-transforming growth factor beta-binding protein 4 precursor (LTBP-4).

MEGF6_HUMAN
NC score	0.066652 (rank : 159)	θ value	θ > 10 (rank : 208)
Query Neighborhood Hits	96	Target Neighborhood Hits	671	Shared Neighborhood Hits	40
SwissProt Accessions	O75095, Q5VV39	Gene names	MEGF6, EGFL3, KIAA0815
Domain Architecture	No domain graphic available
Description	Multiple epidermal growth factor-like domains 6 precursor (EGF-like domain-containing protein 3) (Multiple EGF-like domain protein 3).

TMPS4_HUMAN
NC score	0.066651 (rank : 160)	θ value	θ > 10 (rank : 265)
Query Neighborhood Hits	96	Target Neighborhood Hits	203	Shared Neighborhood Hits	37
SwissProt Accessions	Q9NRS4, Q5XKQ6, Q6UX37, Q9NZA5	Gene names	TMPRSS4, TMPRSS3
Domain Architecture
Description	Transmembrane protease, serine 4 (EC 3.4.21.-) (Membrane-type serine protease 2) (MT-SP2).

BMP1_MOUSE
NC score	0.066143 (rank : 161)	θ value	θ > 10 (rank : 103)
Query Neighborhood Hits	96	Target Neighborhood Hits	236	Shared Neighborhood Hits	35
SwissProt Accessions	P98063	Gene names	Bmp1
Domain Architecture
Description	Bone morphogenetic protein 1 precursor (EC 3.4.24.19) (BMP-1) (Procollagen C-proteinase) (PCP) (Mammalian tolloid protein) (mTld).

TLL2_MOUSE
NC score	0.065664 (rank : 162)	θ value	θ > 10 (rank : 258)
Query Neighborhood Hits	96	Target Neighborhood Hits	240	Shared Neighborhood Hits	36
SwissProt Accessions	Q9WVM6	Gene names	Tll2
Domain Architecture	No domain graphic available
Description	Tolloid-like protein 2 precursor (EC 3.4.24.-).

FA7_HUMAN
NC score	0.065650 (rank : 163)	θ value	θ > 10 (rank : 145)
Query Neighborhood Hits	96	Target Neighborhood Hits	404	Shared Neighborhood Hits	41
SwissProt Accessions	P08709, Q14339, Q5JVF2	Gene names	F7
Domain Architecture
Description	Coagulation factor VII precursor (EC 3.4.21.21) (Serum prothrombin conversion accelerator) (SPCA) (Proconvertin) (Eptacog alfa) [Contains: Factor VII light chain; Factor VII heavy chain].

STAB2_HUMAN
NC score	0.065582 (rank : 164)	θ value	0.0961366 (rank : 60)
Query Neighborhood Hits	96	Target Neighborhood Hits	534	Shared Neighborhood Hits	39
SwissProt Accessions	Q8WWQ8, Q6ZMK2, Q7Z5N9, Q86UR4, Q8IUG9, Q8TES1, Q9H7H7, Q9NRY3	Gene names	STAB2, FEEL2, FELL, FEX2, HARE
Domain Architecture	No domain graphic available
Description	Stabilin-2 precursor (FEEL-2 protein) (Fasciclin EGF-like laminin-type EGF-like and link domain-containing scavenger receptor 1) (FAS1 EGF- like and X-link domain-containing adhesion molecule 2) (Hyaluronan receptor for endocytosis) [Contains: 190 kDa form stabilin-2 (190 kDa hyaluronan receptor for endocytosis)].

BMP1_HUMAN
NC score	0.065549 (rank : 165)	θ value	θ > 10 (rank : 102)
Query Neighborhood Hits	96	Target Neighborhood Hits	233	Shared Neighborhood Hits	35
SwissProt Accessions	P13497, Q13292, Q13872, Q14874, Q99421, Q99422, Q99423, Q9UL38	Gene names	BMP1, PCOLC
Domain Architecture
Description	Bone morphogenetic protein 1 precursor (EC 3.4.24.19) (BMP-1) (Procollagen C-proteinase) (PCP) (Mammalian tolloid protein) (mTld).

FA7_MOUSE
NC score	0.065467 (rank : 166)	θ value	θ > 10 (rank : 146)
Query Neighborhood Hits	96	Target Neighborhood Hits	374	Shared Neighborhood Hits	37
SwissProt Accessions	P70375, Q61109	Gene names	F7, Cf7
Domain Architecture
Description	Coagulation factor VII precursor (EC 3.4.21.21) (Serum prothrombin conversion accelerator) [Contains: Factor VII light chain; Factor VII heavy chain].

CS1B_MOUSE
NC score	0.065332 (rank : 167)	θ value	θ > 10 (rank : 123)
Query Neighborhood Hits	96	Target Neighborhood Hits	361	Shared Neighborhood Hits	40
SwissProt Accessions	Q8CFG8	Gene names	C1sb, C1s
Domain Architecture	No domain graphic available
Description	Complement C1s-B subcomponent precursor (EC 3.4.21.42) (C1 esterase) [Contains: Complement C1s-B subcomponent heavy chain; Complement C1s-B subcomponent light chain].

CREL1_HUMAN
NC score	0.065054 (rank : 168)	θ value	θ > 10 (rank : 118)
Query Neighborhood Hits	96	Target Neighborhood Hits	441	Shared Neighborhood Hits	26
SwissProt Accessions	Q96HD1, Q6I9X5, Q8NFT4, Q9Y409	Gene names	CRELD1, CIRRIN
Domain Architecture	No domain graphic available
Description	Cysteine-rich with EGF-like domain protein 1 precursor.

TLL2_HUMAN
NC score	0.064993 (rank : 169)	θ value	θ > 10 (rank : 257)
Query Neighborhood Hits	96	Target Neighborhood Hits	241	Shared Neighborhood Hits	36
SwissProt Accessions	Q9Y6L7, Q6PJN5, Q9UQ00	Gene names	TLL2, KIAA0932
Domain Architecture	No domain graphic available
Description	Tolloid-like protein 2 precursor (EC 3.4.24.-).

TMPS4_MOUSE
NC score	0.064363 (rank : 170)	θ value	θ > 10 (rank : 266)
Query Neighborhood Hits	96	Target Neighborhood Hits	210	Shared Neighborhood Hits	36
SwissProt Accessions	Q8VCA5	Gene names	Tmprss4, Cap2
Domain Architecture
Description	Transmembrane protease, serine 4 (EC 3.4.21.-) (Channel-activating protease 2) (mCAP2).

FBLN4_HUMAN
NC score	0.064276 (rank : 171)	θ value	θ > 10 (rank : 154)
Query Neighborhood Hits	96	Target Neighborhood Hits	278	Shared Neighborhood Hits	29
SwissProt Accessions	O95967, O75967	Gene names	EFEMP2, FBLN4
Domain Architecture
Description	EGF-containing fibulin-like extracellular matrix protein 2 precursor (Fibulin-4) (FIBL-4) (UPH1 protein).

FBLN4_MOUSE
NC score	0.064218 (rank : 172)	θ value	θ > 10 (rank : 155)
Query Neighborhood Hits	96	Target Neighborhood Hits	270	Shared Neighborhood Hits	28
SwissProt Accessions	Q9WVJ9	Gene names	Efemp2, Fbln4, Mbp1
Domain Architecture
Description	EGF-containing fibulin-like extracellular matrix protein 2 precursor (Fibulin-4) (FIBL-4) (Mutant p53-binding protein 1).

CREL1_MOUSE
NC score	0.063944 (rank : 173)	θ value	θ > 10 (rank : 119)
Query Neighborhood Hits	96	Target Neighborhood Hits	524	Shared Neighborhood Hits	27
SwissProt Accessions	Q91XD7, Q8BGJ8	Gene names	Creld1
Domain Architecture	No domain graphic available
Description	Cysteine-rich with EGF-like domain protein 1 precursor.

FBLN3_HUMAN
NC score	0.063893 (rank : 174)	θ value	θ > 10 (rank : 152)
Query Neighborhood Hits	96	Target Neighborhood Hits	293	Shared Neighborhood Hits	30
SwissProt Accessions	Q12805	Gene names	EFEMP1, FBLN3, FBNL
Domain Architecture
Description	EGF-containing fibulin-like extracellular matrix protein 1 precursor (Fibulin-3) (FIBL-3) (Fibrillin-like protein) (Extracellular protein S1-5).

CS1A_MOUSE
NC score	0.063802 (rank : 175)	θ value	θ > 10 (rank : 122)
Query Neighborhood Hits	96	Target Neighborhood Hits	360	Shared Neighborhood Hits	40
SwissProt Accessions	Q8CG14, Q8BJC4, Q8CH28, Q8VBY4	Gene names	C1sa, C1s
Domain Architecture	No domain graphic available
Description	Complement C1s-A subcomponent precursor (EC 3.4.21.42) (C1 esterase) [Contains: Complement C1s-A subcomponent heavy chain; Complement C1s-A subcomponent light chain].

LTBP2_MOUSE
NC score	0.063673 (rank : 176)	θ value	θ > 10 (rank : 191)
Query Neighborhood Hits	96	Target Neighborhood Hits	617	Shared Neighborhood Hits	35
SwissProt Accessions	O08999, Q8C6W9	Gene names	Ltbp2
Domain Architecture
Description	Latent-transforming growth factor beta-binding protein 2 precursor (LTBP-2).

C1S_HUMAN
NC score	0.063535 (rank : 177)	θ value	θ > 10 (rank : 111)
Query Neighborhood Hits	96	Target Neighborhood Hits	359	Shared Neighborhood Hits	39
SwissProt Accessions	P09871, Q9UCU7, Q9UCU8, Q9UCU9, Q9UCV0, Q9UCV1, Q9UCV2, Q9UCV3, Q9UCV4, Q9UCV5, Q9UM14	Gene names	C1S
Domain Architecture
Description	Complement C1s subcomponent precursor (EC 3.4.21.42) (C1 esterase) [Contains: Complement C1s subcomponent heavy chain; Complement C1s subcomponent light chain].

LTBP3_MOUSE
NC score	0.063320 (rank : 178)	θ value	θ > 10 (rank : 193)
Query Neighborhood Hits	96	Target Neighborhood Hits	475	Shared Neighborhood Hits	36
SwissProt Accessions	Q61810, Q8BNQ6	Gene names	Ltbp3
Domain Architecture
Description	Latent-transforming growth factor beta-binding protein 3 precursor (LTBP-3).

LTBP3_HUMAN
NC score	0.063181 (rank : 179)	θ value	θ > 10 (rank : 192)
Query Neighborhood Hits	96	Target Neighborhood Hits	502	Shared Neighborhood Hits	34
SwissProt Accessions	Q9NS15, O15107, Q96HB9, Q9H7K2, Q9UFN4	Gene names	LTBP3
Domain Architecture
Description	Latent-transforming growth factor beta-binding protein 3 precursor (LTBP-3).

KR107_HUMAN
NC score	0.062722 (rank : 180)	θ value	θ > 10 (rank : 182)
Query Neighborhood Hits	96	Target Neighborhood Hits	330	Shared Neighborhood Hits	28
SwissProt Accessions	P60409, Q70LJ2	Gene names	KRTAP10-7, KAP10.7, KAP18-7, KRTAP10.7, KRTAP18-7, KRTAP18.7
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 10-7 (Keratin-associated protein 10.7) (High sulfur keratin-associated protein 10.7) (Keratin-associated protein 18-7) (Keratin-associated protein 18.7).

NELL2_HUMAN
NC score	0.062318 (rank : 181)	θ value	θ > 10 (rank : 210)
Query Neighborhood Hits	96	Target Neighborhood Hits	449	Shared Neighborhood Hits	34
SwissProt Accessions	Q99435	Gene names	NELL2, NRP2
Domain Architecture
Description	Protein kinase C-binding protein NELL2 precursor (NEL-like protein 2) (Nel-related protein 2).

CO8G_MOUSE
NC score	0.061984 (rank : 182)	θ value	θ > 10 (rank : 117)
Query Neighborhood Hits	96	Target Neighborhood Hits	15	Shared Neighborhood Hits	2
SwissProt Accessions	Q8VCG4	Gene names	C8g
Domain Architecture
Description	Complement component C8 gamma chain precursor.

TMPSD_HUMAN
NC score	0.061939 (rank : 183)	θ value	θ > 10 (rank : 269)
Query Neighborhood Hits	96	Target Neighborhood Hits	333	Shared Neighborhood Hits	32
SwissProt Accessions	Q9BYE2, Q86YM4, Q96JY8, Q9BYE1	Gene names	TMPRSS13, MSP, TMPRSS11
Domain Architecture	No domain graphic available
Description	Transmembrane protease, serine 13 (EC 3.4.21.-) (Mosaic serine protease) (Membrane-type mosaic serine protease).

FBLN3_MOUSE
NC score	0.061318 (rank : 184)	θ value	θ > 10 (rank : 153)
Query Neighborhood Hits	96	Target Neighborhood Hits	279	Shared Neighborhood Hits	28
SwissProt Accessions	Q8BPB5, Q6Y3N6	Gene names	Efemp1, Fbln3
Domain Architecture	No domain graphic available
Description	EGF-containing fibulin-like extracellular matrix protein 1 precursor (Fibulin-3) (FIBL-3).

CUBN_HUMAN
NC score	0.060584 (rank : 185)	θ value	θ > 10 (rank : 126)
Query Neighborhood Hits	96	Target Neighborhood Hits	482	Shared Neighborhood Hits	46
SwissProt Accessions	O60494, Q5VTA6, Q96RU9	Gene names	CUBN, IFCR
Domain Architecture	No domain graphic available
Description	Cubilin precursor (Intrinsic factor-cobalamin receptor) (Intrinsic factor-vitamin B12 receptor) (460 kDa receptor) (Intestinal intrinsic factor receptor).

HABP2_MOUSE
NC score	0.060530 (rank : 186)	θ value	θ > 10 (rank : 168)
Query Neighborhood Hits	96	Target Neighborhood Hits	445	Shared Neighborhood Hits	39
SwissProt Accessions	Q8K0D2	Gene names	Habp2, Phbp
Domain Architecture	No domain graphic available
Description	Hyaluronan-binding protein 2 precursor (EC 3.4.21.-) (Plasma hyaluronan-binding protein) [Contains: Hyaluronan-binding protein 2 50 kDa heavy chain; Hyaluronan-binding protein 2 50 kDa heavy chain alternate form; Hyaluronan-binding protein 2 27 kDa light chain; Hyaluronan-binding protein 2 27 kDa light chain alternate form].

TM11E_HUMAN
NC score	0.060485 (rank : 187)	θ value	θ > 10 (rank : 261)
Query Neighborhood Hits	96	Target Neighborhood Hits	181	Shared Neighborhood Hits	16
SwissProt Accessions	Q9UL52, Q6UW31	Gene names	TMPRSS11E, DESC1
Domain Architecture	No domain graphic available
Description	Transmembrane protease, serine 11E precursor (EC 3.4.21.-) (Serine protease DESC1) [Contains: Transmembrane protease, serine 11E non- catalytic chain; Transmembrane protease, serine 11E catalytic chain].

JAG2_MOUSE
NC score	0.060432 (rank : 188)	θ value	θ > 10 (rank : 177)
Query Neighborhood Hits	96	Target Neighborhood Hits	504	Shared Neighborhood Hits	40
SwissProt Accessions	Q9QYE5, O55139, O70219	Gene names	Jag2
Domain Architecture
Description	Jagged-2 precursor (Jagged2).

SREC_HUMAN
NC score	0.060414 (rank : 189)	θ value	0.813845 (rank : 73)
Query Neighborhood Hits	96	Target Neighborhood Hits	645	Shared Neighborhood Hits	40
SwissProt Accessions	Q14162, O43701	Gene names	SCARF1, KIAA0149, SREC
Domain Architecture	No domain graphic available
Description	Endothelial cells scavenger receptor precursor (Acetyl LDL receptor) (Scavenger receptor class F member 1).

FA12_HUMAN
NC score	0.060289 (rank : 190)	θ value	θ > 10 (rank : 144)
Query Neighborhood Hits	96	Target Neighborhood Hits	425	Shared Neighborhood Hits	28
SwissProt Accessions	P00748, P78339	Gene names	F12
Domain Architecture
Description	Coagulation factor XII precursor (EC 3.4.21.38) (Hageman factor) (HAF) [Contains: Coagulation factor XIIa heavy chain; Beta-factor XIIa part 1; Beta-factor XIIa part 2; Coagulation factor XIIa light chain].

NELL2_MOUSE
NC score	0.060259 (rank : 191)	θ value	θ > 10 (rank : 211)
Query Neighborhood Hits	96	Target Neighborhood Hits	436	Shared Neighborhood Hits	31
SwissProt Accessions	Q61220	Gene names	Nell2, Mel91
Domain Architecture
Description	Protein kinase C-binding protein NELL2 precursor (NEL-like protein 2) (MEL91 protein).

JAG2_HUMAN
NC score	0.060245 (rank : 192)	θ value	θ > 10 (rank : 176)
Query Neighborhood Hits	96	Target Neighborhood Hits	491	Shared Neighborhood Hits	40
SwissProt Accessions	Q9Y219, Q9UE17, Q9UE99, Q9UNK8, Q9Y6P9, Q9Y6Q0	Gene names	JAG2
Domain Architecture
Description	Jagged-2 precursor (Jagged2) (HJ2).

DLL1_HUMAN
NC score	0.059952 (rank : 193)	θ value	θ > 10 (rank : 129)
Query Neighborhood Hits	96	Target Neighborhood Hits	455	Shared Neighborhood Hits	44
SwissProt Accessions	O00548, Q9NU41, Q9UJV2	Gene names	DLL1
Domain Architecture
Description	Delta-like protein 1 precursor (Drosophila Delta homolog 1) (Delta1) (H-Delta-1).

TENX_HUMAN
NC score	0.059880 (rank : 194)	θ value	θ > 10 (rank : 250)
Query Neighborhood Hits	96	Target Neighborhood Hits	789	Shared Neighborhood Hits	42
SwissProt Accessions	P22105, P78530, P78531, Q08424, Q9UMG7	Gene names	TNXB, HXBL, TNX, XB
Domain Architecture
Description	Tenascin-X precursor (TN-X) (Hexabrachion-like protein).

TMPSD_MOUSE
NC score	0.059865 (rank : 195)	θ value	θ > 10 (rank : 270)
Query Neighborhood Hits	96	Target Neighborhood Hits	334	Shared Neighborhood Hits	23
SwissProt Accessions	Q5U405, Q8CFE0, Q91VQ8	Gene names	Tmprss13, Msp
Domain Architecture	No domain graphic available
Description	Transmembrane protease, serine 13 (EC 3.4.21.-) (Mosaic serine protease) (Membrane-type mosaic serine protease).

HGFA_HUMAN
NC score	0.059507 (rank : 196)	θ value	θ > 10 (rank : 171)
Query Neighborhood Hits	96	Target Neighborhood Hits	436	Shared Neighborhood Hits	31
SwissProt Accessions	Q04756, Q14726	Gene names	HGFAC
Domain Architecture
Description	Hepatocyte growth factor activator precursor (EC 3.4.21.-) (HGF activator) (HGFA) [Contains: Hepatocyte growth factor activator short chain; Hepatocyte growth factor activator long chain].

NELL1_HUMAN
NC score	0.059154 (rank : 197)	θ value	θ > 10 (rank : 209)
Query Neighborhood Hits	96	Target Neighborhood Hits	451	Shared Neighborhood Hits	31
SwissProt Accessions	Q92832, Q9Y472	Gene names	NELL1, NRP1
Domain Architecture
Description	Protein kinase C-binding protein NELL1 precursor (NEL-like protein 1) (Nel-related protein 1).

HGFA_MOUSE
NC score	0.059104 (rank : 198)	θ value	θ > 10 (rank : 172)
Query Neighborhood Hits	96	Target Neighborhood Hits	419	Shared Neighborhood Hits	31
SwissProt Accessions	Q9R098, Q9JKV4	Gene names	Hgfac
Domain Architecture
Description	Hepatocyte growth factor activator precursor (EC 3.4.21.-) (HGF activator) (HGFA) [Contains: Hepatocyte growth factor activator short chain; Hepatocyte growth factor activator long chain].

TM11E_MOUSE
NC score	0.059046 (rank : 199)	θ value	θ > 10 (rank : 262)
Query Neighborhood Hits	96	Target Neighborhood Hits	176	Shared Neighborhood Hits	16
SwissProt Accessions	Q5S248, Q8BM10	Gene names	Tmprss11e, Desc1
Domain Architecture	No domain graphic available
Description	Transmembrane protease, serine 11E precursor (EC 3.4.21.-) (Serine protease DESC1) [Contains: Transmembrane protease, serine 11E non- catalytic chain; Transmembrane protease, serine 11E catalytic chain].

RXFP2_HUMAN
NC score	0.058994 (rank : 200)	θ value	8.99809 (rank : 96)
Query Neighborhood Hits	96	Target Neighborhood Hits	736	Shared Neighborhood Hits	56
SwissProt Accessions	Q8WXD0	Gene names	RXFP2, GPR106, GREAT, LGR8
Domain Architecture
Description	Relaxin receptor 2 (Relaxin family peptide receptor 2) (Leucine-rich repeat-containing G-protein coupled receptor 8) (G-protein coupled receptor affecting testicular descent) (G-protein coupled receptor 106).

STAB2_MOUSE
NC score	0.058836 (rank : 201)	θ value	θ > 10 (rank : 246)
Query Neighborhood Hits	96	Target Neighborhood Hits	528	Shared Neighborhood Hits	38
SwissProt Accessions	Q8R4U0, Q8BM87	Gene names	Stab2
Domain Architecture	No domain graphic available
Description	Stabilin-2 precursor [Contains: Short form stabilin-2].

CO8G_HUMAN
NC score	0.058681 (rank : 202)	θ value	θ > 10 (rank : 116)
Query Neighborhood Hits	96	Target Neighborhood Hits	10	Shared Neighborhood Hits	2
SwissProt Accessions	P07360, Q5SQ07	Gene names	C8G
Domain Architecture
Description	Complement component C8 gamma chain precursor.

NOTC1_MOUSE
NC score	0.058461 (rank : 203)	θ value	θ > 10 (rank : 223)
Query Neighborhood Hits	96	Target Neighborhood Hits	916	Shared Neighborhood Hits	44
SwissProt Accessions	Q01705, Q06007, Q61905, Q99JC2, Q9QW58, Q9R0X7	Gene names	Notch1, Motch
Domain Architecture
Description	Neurogenic locus notch homolog protein 1 precursor (Notch 1) (Motch A) (mT14) (p300) [Contains: Notch 1 extracellular truncation; Notch 1 intracellular domain].

POLS2_HUMAN
NC score	0.058393 (rank : 204)	θ value	θ > 10 (rank : 227)
Query Neighborhood Hits	96	Target Neighborhood Hits	192	Shared Neighborhood Hits	18
SwissProt Accessions	Q5K4E3, Q8NBY4	Gene names	PRSS36
Domain Architecture	No domain graphic available
Description	Polyserase-2 precursor (EC 3.4.21.-) (Polyserine protease 2) (Protease serine 36).

KR106_HUMAN
NC score	0.058223 (rank : 205)	θ value	θ > 10 (rank : 181)
Query Neighborhood Hits	96	Target Neighborhood Hits	347	Shared Neighborhood Hits	30
SwissProt Accessions	P60371	Gene names	KRTAP10-6, KAP10.6, KAP18-6, KRTAP10.6, KRTAP18-6, KRTAP18.6
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 10-6 (Keratin-associated protein 10.6) (High sulfur keratin-associated protein 10.6) (Keratin-associated protein 18-6) (Keratin-associated protein 18.6).

HABP2_HUMAN
NC score	0.057978 (rank : 206)	θ value	θ > 10 (rank : 167)
Query Neighborhood Hits	96	Target Neighborhood Hits	431	Shared Neighborhood Hits	32
SwissProt Accessions	Q14520, O00663	Gene names	HABP2, HGFAL, PHBP
Domain Architecture	No domain graphic available
Description	Hyaluronan-binding protein 2 precursor (EC 3.4.21.-) (Plasma hyaluronan-binding protein) (Hepatocyte growth factor activator-like protein) (Factor VII-activating protease) (Factor seven-activating protease) (FSAP) [Contains: Hyaluronan-binding protein 2 50 kDa heavy chain; Hyaluronan-binding protein 2 50 kDa heavy chain alternate form; Hyaluronan-binding protein 2 27 kDa light chain; Hyaluronan-binding protein 2 27 kDa light chain alternate form].

TM11D_MOUSE
NC score	0.057976 (rank : 207)	θ value	θ > 10 (rank : 260)
Query Neighborhood Hits	96	Target Neighborhood Hits	179	Shared Neighborhood Hits	16
SwissProt Accessions	Q8VHK8, Q7TNX3, Q8VDV1	Gene names	Tmprss11d, Mat
Domain Architecture	No domain graphic available
Description	Transmembrane protease, serine 11D precursor (EC 3.4.21.-) (Airway trypsin-like protease) (AT) (Adrenal secretory serine protease) (AsP) [Contains: Transmembrane protease, serine 11D non-catalytic chain; Transmembrane protease, serine 11D catalytic chain].

POLS2_MOUSE
NC score	0.057821 (rank : 208)	θ value	θ > 10 (rank : 228)
Query Neighborhood Hits	96	Target Neighborhood Hits	188	Shared Neighborhood Hits	16
SwissProt Accessions	Q5K2P8	Gene names	Prss36
Domain Architecture	No domain graphic available
Description	Polyserase-2 precursor (EC 3.4.21.-) (Polyserine protease 2) (Protease serine 36).

DESC4_MOUSE
NC score	0.057736 (rank : 209)	θ value	θ > 10 (rank : 128)
Query Neighborhood Hits	96	Target Neighborhood Hits	176	Shared Neighborhood Hits	16
SwissProt Accessions	Q8BZ10, Q8BZ04	Gene names	Desc4
Domain Architecture	No domain graphic available
Description	Serine protease DESC4 precursor (EC 3.4.21.-) [Contains: Serine protease DESC4 non-catalytic chain; Serine protease DESC4 catalytic chain].

JAG1_MOUSE
NC score	0.057660 (rank : 210)	θ value	θ > 10 (rank : 175)
Query Neighborhood Hits	96	Target Neighborhood Hits	518	Shared Neighborhood Hits	37
SwissProt Accessions	Q9QXX0	Gene names	Jag1
Domain Architecture
Description	Jagged-1 precursor (Jagged1) (CD339 antigen).

DLL1_MOUSE
NC score	0.057466 (rank : 211)	θ value	θ > 10 (rank : 130)
Query Neighborhood Hits	96	Target Neighborhood Hits	456	Shared Neighborhood Hits	40
SwissProt Accessions	Q61483	Gene names	Dll1
Domain Architecture
Description	Delta-like protein 1 precursor (Drosophila Delta homolog 1) (Delta1).

LCE3B_HUMAN
NC score	0.057456 (rank : 212)	θ value	θ > 10 (rank : 185)
Query Neighborhood Hits	96	Target Neighborhood Hits	47	Shared Neighborhood Hits	10
SwissProt Accessions	Q5TA77	Gene names	LCE3B, LEP14
Domain Architecture	No domain graphic available
Description	Late cornified envelope protein 3B (Late envelope protein 14).

TEST_HUMAN
NC score	0.057441 (rank : 213)	θ value	θ > 10 (rank : 251)
Query Neighborhood Hits	96	Target Neighborhood Hits	172	Shared Neighborhood Hits	16
SwissProt Accessions	Q9Y6M0, Q9NS34, Q9P2V6	Gene names	PRSS21, ESP1, TEST1
Domain Architecture
Description	Testisin precursor (EC 3.4.21.-) (Eosinophil serine protease 1) (ESP- 1).

TMPS5_HUMAN
NC score	0.057298 (rank : 214)	θ value	θ > 10 (rank : 267)
Query Neighborhood Hits	96	Target Neighborhood Hits	181	Shared Neighborhood Hits	16
SwissProt Accessions	Q9H3S3	Gene names	TMPRSS5
Domain Architecture
Description	Transmembrane protease, serine 5 (EC 3.4.21.-) (Spinesin).

TMPS5_MOUSE
NC score	0.057138 (rank : 215)	θ value	θ > 10 (rank : 268)
Query Neighborhood Hits	96	Target Neighborhood Hits	185	Shared Neighborhood Hits	16
SwissProt Accessions	Q9ER04, Q9ER02, Q9ER03	Gene names	Tmprss5
Domain Architecture
Description	Transmembrane protease, serine 5 (EC 3.4.21.-) (Spinesin).

TPA_HUMAN
NC score	0.056658 (rank : 216)	θ value	θ > 10 (rank : 272)
Query Neighborhood Hits	96	Target Neighborhood Hits	324	Shared Neighborhood Hits	27
SwissProt Accessions	P00750, Q15103, Q7Z7N2, Q86YK8, Q9BU99	Gene names	PLAT
Domain Architecture
Description	Tissue-type plasminogen activator precursor (EC 3.4.21.68) (tPA) (t- PA) (t-plasminogen activator) (Alteplase) (Reteplase) [Contains: Tissue-type plasminogen activator chain A; Tissue-type plasminogen activator chain B].

HEPS_MOUSE
NC score	0.056600 (rank : 217)	θ value	θ > 10 (rank : 170)
Query Neighborhood Hits	96	Target Neighborhood Hits	178	Shared Neighborhood Hits	16
SwissProt Accessions	O35453, Q9CW97	Gene names	Hpn
Domain Architecture
Description	Serine protease hepsin (EC 3.4.21.-) [Contains: Serine protease hepsin non-catalytic chain; Serine protease hepsin catalytic chain].

JAG1_HUMAN
NC score	0.056563 (rank : 218)	θ value	θ > 10 (rank : 174)
Query Neighborhood Hits	96	Target Neighborhood Hits	514	Shared Neighborhood Hits	38
SwissProt Accessions	P78504, O14902, O15122, Q15816	Gene names	JAG1, JAGL1
Domain Architecture
Description	Jagged-1 precursor (Jagged1) (hJ1) (CD339 antigen).

TM11D_HUMAN
NC score	0.056532 (rank : 219)	θ value	θ > 10 (rank : 259)
Query Neighborhood Hits	96	Target Neighborhood Hits	176	Shared Neighborhood Hits	16
SwissProt Accessions	O60235	Gene names	TMPRSS11D, HAT
Domain Architecture
Description	Transmembrane protease, serine 11D precursor (EC 3.4.21.-) (Airway trypsin-like protease) [Contains: Transmembrane protease, serine 11D non-catalytic chain; Transmembrane protease, serine 11D catalytic chain].

HEPS_HUMAN
NC score	0.056349 (rank : 220)	θ value	θ > 10 (rank : 169)
Query Neighborhood Hits	96	Target Neighborhood Hits	178	Shared Neighborhood Hits	16
SwissProt Accessions	P05981	Gene names	HPN, TMPRSS1
Domain Architecture
Description	Serine protease hepsin (EC 3.4.21.-) (Transmembrane protease, serine 1) [Contains: Serine protease hepsin non-catalytic chain; Serine protease hepsin catalytic chain].

CRUM1_HUMAN
NC score	0.056265 (rank : 221)	θ value	θ > 10 (rank : 120)
Query Neighborhood Hits	96	Target Neighborhood Hits	457	Shared Neighborhood Hits	38
SwissProt Accessions	P82279, Q5K3A6, Q5TC28, Q5VUT1, Q6N027, Q8WWY0	Gene names	CRB1
Domain Architecture
Description	Crumbs homolog 1 precursor.

KLKB1_MOUSE
NC score	0.056182 (rank : 222)	θ value	θ > 10 (rank : 179)
Query Neighborhood Hits	96	Target Neighborhood Hits	177	Shared Neighborhood Hits	16
SwissProt Accessions	P26262	Gene names	Klkb1, Klk3, Pk
Domain Architecture
Description	Plasma kallikrein precursor (EC 3.4.21.34) (Plasma prekallikrein) (Kininogenin) (Fletcher factor) [Contains: Plasma kallikrein heavy chain; Plasma kallikrein light chain].

ACRO_HUMAN
NC score	0.056114 (rank : 223)	θ value	θ > 10 (rank : 97)
Query Neighborhood Hits	96	Target Neighborhood Hits	291	Shared Neighborhood Hits	16
SwissProt Accessions	P10323, Q6ICK2	Gene names	ACR, ACRS
Domain Architecture
Description	Acrosin precursor (EC 3.4.21.10) [Contains: Acrosin light chain; Acrosin heavy chain].

PRS27_HUMAN
NC score	0.055773 (rank : 224)	θ value	θ > 10 (rank : 235)
Query Neighborhood Hits	96	Target Neighborhood Hits	177	Shared Neighborhood Hits	16
SwissProt Accessions	Q9BQR3	Gene names	PRSS27, MPN
Domain Architecture
Description	Protease serine 27 precursor (EC 3.4.21.-) (Marapsin) (Pancreasin) (Channel-activating protease 2) (CAPH2).

TPA_MOUSE
NC score	0.055747 (rank : 225)	θ value	θ > 10 (rank : 273)
Query Neighborhood Hits	96	Target Neighborhood Hits	335	Shared Neighborhood Hits	27
SwissProt Accessions	P11214, Q91VP2	Gene names	Plat
Domain Architecture
Description	Tissue-type plasminogen activator precursor (EC 3.4.21.68) (tPA) (t- PA) (t-plasminogen activator) [Contains: Tissue-type plasminogen activator chain A; Tissue-type plasminogen activator chain B].

RXFP2_MOUSE
NC score	0.055696 (rank : 226)	θ value	4.03905 (rank : 89)
Query Neighborhood Hits	96	Target Neighborhood Hits	760	Shared Neighborhood Hits	58
SwissProt Accessions	Q91ZZ5	Gene names	Rxfp2, Gpr106, Great, Lgr8
Domain Architecture
Description	Relaxin receptor 2 (Relaxin family peptide receptor 2) (Leucine-rich repeat-containing G-protein coupled receptor 8) (G-protein coupled receptor affecting testicular descent) (G-protein coupled receptor 106).

PRS27_MOUSE
NC score	0.055473 (rank : 227)	θ value	θ > 10 (rank : 236)
Query Neighborhood Hits	96	Target Neighborhood Hits	175	Shared Neighborhood Hits	16
SwissProt Accessions	Q8BJR6	Gene names	Prss27, Mpn
Domain Architecture	No domain graphic available
Description	Protease serine 27 precursor (EC 3.4.21.-) (Marapsin) (Pancreasin).

FA11_MOUSE
NC score	0.055455 (rank : 228)	θ value	θ > 10 (rank : 143)
Query Neighborhood Hits	96	Target Neighborhood Hits	180	Shared Neighborhood Hits	16
SwissProt Accessions	Q91Y47	Gene names	F11
Domain Architecture
Description	Coagulation factor XI precursor (EC 3.4.21.27) (Plasma thromboplastin antecedent) (PTA) (FXI) [Contains: Coagulation factor XIa heavy chain; Coagulation factor XIa light chain].

PRSS8_MOUSE
NC score	0.055343 (rank : 229)	θ value	θ > 10 (rank : 238)
Query Neighborhood Hits	96	Target Neighborhood Hits	177	Shared Neighborhood Hits	17
SwissProt Accessions	Q9ESD1	Gene names	Prss8, Cap1
Domain Architecture
Description	Prostasin precursor (EC 3.4.21.-) (Channel-activating protease 1) [Contains: Prostasin light chain; Prostasin heavy chain].

KR104_HUMAN
NC score	0.055249 (rank : 230)	θ value	θ > 10 (rank : 180)
Query Neighborhood Hits	96	Target Neighborhood Hits	313	Shared Neighborhood Hits	23
SwissProt Accessions	P60372	Gene names	KRTAP10-4, KAP10.4, KAP18-4, KRTAP10.4, KRTAP18-4, KRTAP18.4
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 10-4 (Keratin-associated protein 10.4) (High sulfur keratin-associated protein 10.4) (Keratin-associated protein 18-4) (Keratin-associated protein 18.4).

TEST_MOUSE
NC score	0.055231 (rank : 231)	θ value	θ > 10 (rank : 252)
Query Neighborhood Hits	96	Target Neighborhood Hits	174	Shared Neighborhood Hits	16
SwissProt Accessions	Q9JHJ7, Q9DA14	Gene names	Prss21
Domain Architecture
Description	Testisin precursor (EC 3.4.21.-) (Tryptase 4).

SUSD1_HUMAN
NC score	0.055198 (rank : 232)	θ value	θ > 10 (rank : 247)
Query Neighborhood Hits	96	Target Neighborhood Hits	285	Shared Neighborhood Hits	22
SwissProt Accessions	Q6UWL2, Q5T8V7, Q6P9G7, Q8WU83, Q9H6V2, Q9NTA7	Gene names	SUSD1
Domain Architecture	No domain graphic available
Description	Sushi domain-containing protein 1 precursor.

KLKB1_HUMAN
NC score	0.055177 (rank : 233)	θ value	θ > 10 (rank : 178)
Query Neighborhood Hits	96	Target Neighborhood Hits	183	Shared Neighborhood Hits	16
SwissProt Accessions	P03952	Gene names	KLKB1, KLK3
Domain Architecture
Description	Plasma kallikrein precursor (EC 3.4.21.34) (Plasma prekallikrein) (Kininogenin) (Fletcher factor) [Contains: Plasma kallikrein heavy chain; Plasma kallikrein light chain].

FA11_HUMAN
NC score	0.055076 (rank : 234)	θ value	θ > 10 (rank : 142)
Query Neighborhood Hits	96	Target Neighborhood Hits	178	Shared Neighborhood Hits	16
SwissProt Accessions	P03951, Q9Y495	Gene names	F11
Domain Architecture
Description	Coagulation factor XI precursor (EC 3.4.21.27) (Plasma thromboplastin antecedent) (PTA) (FXI) [Contains: Coagulation factor XIa heavy chain; Coagulation factor XIa light chain].

WFDC3_HUMAN
NC score	0.055074 (rank : 235)	θ value	θ > 10 (rank : 289)
Query Neighborhood Hits	96	Target Neighborhood Hits	138	Shared Neighborhood Hits	16
SwissProt Accessions	Q8IUB2, Q8TC52, Q9BQP3, Q9BQP4	Gene names	WFDC3, WAP14
Domain Architecture	No domain graphic available
Description	WAP four-disulfide core domain protein 3 precursor (Putative protease inhibitor WAP14).

NOTC1_HUMAN
NC score	0.054919 (rank : 236)	θ value	θ > 10 (rank : 222)
Query Neighborhood Hits	96	Target Neighborhood Hits	906	Shared Neighborhood Hits	41
SwissProt Accessions	P46531	Gene names	NOTCH1, TAN1
Domain Architecture
Description	Neurogenic locus notch homolog protein 1 precursor (Notch 1) (hN1) (Translocation-associated notch protein TAN-1) [Contains: Notch 1 extracellular truncation; Notch 1 intracellular domain].

ACRO_MOUSE
NC score	0.054917 (rank : 237)	θ value	θ > 10 (rank : 98)
Query Neighborhood Hits	96	Target Neighborhood Hits	185	Shared Neighborhood Hits	16
SwissProt Accessions	P23578	Gene names	Acr
Domain Architecture
Description	Acrosin precursor (EC 3.4.21.10) [Contains: Acrosin light chain; Acrosin heavy chain].

EGFL7_HUMAN
NC score	0.054778 (rank : 238)	θ value	θ > 10 (rank : 133)
Query Neighborhood Hits	96	Target Neighborhood Hits	325	Shared Neighborhood Hits	24
SwissProt Accessions	Q9UHF1, Q5M7Y5, Q5VUD5, Q96EG0	Gene names	EGFL7, MEGF7
Domain Architecture	No domain graphic available
Description	EGF-like domain-containing protein 7 precursor (Multiple EGF-like domain protein 7) (Multiple epidermal growth factor-like domain protein 7) (Vascular endothelial statin) (VE-statin) (NOTCH4-like protein) (ZNEU1).

TMSP8_MOUSE
NC score	0.054729 (rank : 239)	θ value	θ > 10 (rank : 271)
Query Neighborhood Hits	96	Target Neighborhood Hits	176	Shared Neighborhood Hits	18
SwissProt Accessions	Q9QYZ9, Q91XC4	Gene names	Tmprss8, Disp
Domain Architecture
Description	Transmembrane serine protease 8 precursor (EC 3.4.21.-) (Distal intestinal serine protease).

TSP50_HUMAN
NC score	0.054631 (rank : 240)	θ value	θ > 10 (rank : 283)
Query Neighborhood Hits	96	Target Neighborhood Hits	178	Shared Neighborhood Hits	16
SwissProt Accessions	Q9UI38	Gene names	TSP50
Domain Architecture
Description	Testis-specific protease-like protein 50 precursor.

CRUM1_MOUSE
NC score	0.054616 (rank : 241)	θ value	θ > 10 (rank : 121)
Query Neighborhood Hits	96	Target Neighborhood Hits	444	Shared Neighborhood Hits	40
SwissProt Accessions	Q8VHS2, Q6ST50, Q71JF2, Q8BGR4	Gene names	Crb1
Domain Architecture	No domain graphic available
Description	Crumbs homolog 1 precursor.

PRSS8_HUMAN
NC score	0.054536 (rank : 242)	θ value	θ > 10 (rank : 237)
Query Neighborhood Hits	96	Target Neighborhood Hits	177	Shared Neighborhood Hits	17
SwissProt Accessions	Q16651, Q9UCA3	Gene names	PRSS8
Domain Architecture
Description	Prostasin precursor (EC 3.4.21.-) [Contains: Prostasin light chain; Prostasin heavy chain].

BSSP4_HUMAN
NC score	0.054427 (rank : 243)	θ value	θ > 10 (rank : 104)
Query Neighborhood Hits	96	Target Neighborhood Hits	176	Shared Neighborhood Hits	16
SwissProt Accessions	Q9GZN4, O43342, Q6UXE0	Gene names	PRSS22, BSSP4, PRSS26
Domain Architecture
Description	Brain-specific serine protease 4 precursor (EC 3.4.21.-) (BSSP-4) (Serine protease 22) (Tryptase epsilon).

MATN1_MOUSE
NC score	0.054424 (rank : 244)	θ value	θ > 10 (rank : 200)
Query Neighborhood Hits	96	Target Neighborhood Hits	186	Shared Neighborhood Hits	20
SwissProt Accessions	P51942	Gene names	Matn1, Cmp, Crtm
Domain Architecture
Description	Cartilage matrix protein precursor (Matrilin-1).

NOTC2_MOUSE
NC score	0.054396 (rank : 245)	θ value	θ > 10 (rank : 225)
Query Neighborhood Hits	96	Target Neighborhood Hits	1069	Shared Neighborhood Hits	46
SwissProt Accessions	O35516, Q06008, Q60941	Gene names	Notch2
Domain Architecture
Description	Neurogenic locus notch homolog protein 2 precursor (Notch 2) (Motch B) [Contains: Notch 2 extracellular truncation; Notch 2 intracellular domain].

TRYG1_HUMAN
NC score	0.054279 (rank : 246)	θ value	θ > 10 (rank : 281)
Query Neighborhood Hits	96	Target Neighborhood Hits	179	Shared Neighborhood Hits	16
SwissProt Accessions	Q9NRR2, Q96RZ8, Q9C015, Q9NRQ8, Q9UBB2	Gene names	TPSG1, TMT
Domain Architecture
Description	Tryptase gamma precursor (EC 3.4.21.-) (Transmembrane tryptase) [Contains: Tryptase gamma light chain; Tryptase gamma heavy chain].

TRYG1_MOUSE
NC score	0.054265 (rank : 247)	θ value	θ > 10 (rank : 282)
Query Neighborhood Hits	96	Target Neighborhood Hits	181	Shared Neighborhood Hits	16
SwissProt Accessions	Q9QUL7	Gene names	Tpsg1, Tmt
Domain Architecture
Description	Tryptase gamma precursor (EC 3.4.21.-) (Transmembrane tryptase) [Contains: Tryptase gamma light chain; Tryptase gamma heavy chain].

SREC2_HUMAN
NC score	0.054169 (rank : 248)	θ value	θ > 10 (rank : 242)
Query Neighborhood Hits	96	Target Neighborhood Hits	645	Shared Neighborhood Hits	34
SwissProt Accessions	Q96GP6, Q8IXF3, Q9BW74	Gene names	SCARF2, SREC2, SREPCR
Domain Architecture	No domain graphic available
Description	Scavenger receptor class F member 2 precursor (Scavenger receptor expressed by endothelial cells 2 protein) (SREC-II) (SRECRP-1).

NOTC2_HUMAN
NC score	0.054079 (rank : 249)	θ value	θ > 10 (rank : 224)
Query Neighborhood Hits	96	Target Neighborhood Hits	1113	Shared Neighborhood Hits	44
SwissProt Accessions	Q04721, Q99734, Q9H240	Gene names	NOTCH2
Domain Architecture
Description	Neurogenic locus notch homolog protein 2 precursor (Notch 2) (hN2) [Contains: Notch 2 extracellular truncation; Notch 2 intracellular domain].

MATN1_HUMAN
NC score	0.054052 (rank : 250)	θ value	θ > 10 (rank : 199)
Query Neighborhood Hits	96	Target Neighborhood Hits	191	Shared Neighborhood Hits	21
SwissProt Accessions	P21941	Gene names	MATN1, CMP, CRTM
Domain Architecture
Description	Cartilage matrix protein precursor (Matrilin-1).

STAB1_MOUSE
NC score	0.054051 (rank : 251)	θ value	θ > 10 (rank : 245)
Query Neighborhood Hits	96	Target Neighborhood Hits	566	Shared Neighborhood Hits	35
SwissProt Accessions	Q8R4Y4, Q8K0K6, Q8VC09	Gene names	Stab1, Feel1
Domain Architecture
Description	Stabilin-1 precursor (FEEL-1 protein).

UROK_MOUSE
NC score	0.053492 (rank : 252)	θ value	θ > 10 (rank : 285)
Query Neighborhood Hits	96	Target Neighborhood Hits	273	Shared Neighborhood Hits	24
SwissProt Accessions	P06869	Gene names	Plau
Domain Architecture
Description	Urokinase-type plasminogen activator precursor (EC 3.4.21.73) (uPA) (U-plasminogen activator) [Contains: Urokinase-type plasminogen activator long chain A; Urokinase-type plasminogen activator short chain A; Urokinase-type plasminogen activator chain B].

STAB1_HUMAN
NC score	0.053394 (rank : 253)	θ value	θ > 10 (rank : 244)
Query Neighborhood Hits	96	Target Neighborhood Hits	546	Shared Neighborhood Hits	40
SwissProt Accessions	Q9NY15, Q8IUH0, Q8IUH1, Q93072	Gene names	STAB1, FEEL1, KIAA0246
Domain Architecture
Description	Stabilin-1 precursor (FEEL-1 protein) (MS-1 antigen).

BSSP4_MOUSE
NC score	0.053347 (rank : 254)	θ value	θ > 10 (rank : 105)
Query Neighborhood Hits	96	Target Neighborhood Hits	179	Shared Neighborhood Hits	16
SwissProt Accessions	Q9ER10	Gene names	Prss22, Bssp4, Prss26
Domain Architecture
Description	Brain-specific serine protease 4 precursor (EC 3.4.21.-) (BSSP-4) (Serine protease 22) (Tryptase epsilon).

CTRB1_HUMAN
NC score	0.053028 (rank : 255)	θ value	θ > 10 (rank : 124)
Query Neighborhood Hits	96	Target Neighborhood Hits	176	Shared Neighborhood Hits	16
SwissProt Accessions	P17538	Gene names	CTRB1, CTRB
Domain Architecture
Description	Chymotrypsinogen B precursor (EC 3.4.21.1) [Contains: Chymotrypsin B chain A; Chymotrypsin B chain B; Chymotrypsin B chain C].

CLCR_HUMAN
NC score	0.052949 (rank : 256)	θ value	θ > 10 (rank : 114)
Query Neighborhood Hits	96	Target Neighborhood Hits	177	Shared Neighborhood Hits	16
SwissProt Accessions	Q99895, O00765, Q9NUH5	Gene names	CTRC, CLCR
Domain Architecture
Description	Caldecrin precursor (EC 3.4.21.2) (Chymotrypsin C).

MCPT6_MOUSE
NC score	0.052722 (rank : 257)	θ value	θ > 10 (rank : 207)
Query Neighborhood Hits	96	Target Neighborhood Hits	175	Shared Neighborhood Hits	16
SwissProt Accessions	P21845, Q61962	Gene names	Mcpt6
Domain Architecture
Description	Mast cell protease 6 precursor (EC 3.4.21.59) (MMCP-6) (Tryptase).

CTRL_HUMAN
NC score	0.052717 (rank : 258)	θ value	θ > 10 (rank : 125)
Query Neighborhood Hits	96	Target Neighborhood Hits	179	Shared Neighborhood Hits	16
SwissProt Accessions	P40313	Gene names	CTRL, CTRL1
Domain Architecture
Description	Chymotrypsin-like protease CTRL-1 precursor (EC 3.4.21.-).

UROK_HUMAN
NC score	0.052647 (rank : 259)	θ value	θ > 10 (rank : 284)
Query Neighborhood Hits	96	Target Neighborhood Hits	272	Shared Neighborhood Hits	24
SwissProt Accessions	P00749, Q15844, Q16618, Q969W6	Gene names	PLAU
Domain Architecture
Description	Urokinase-type plasminogen activator precursor (EC 3.4.21.73) (uPA) (U-plasminogen activator) [Contains: Urokinase-type plasminogen activator long chain A; Urokinase-type plasminogen activator short chain A; Urokinase-type plasminogen activator chain B].

NOTC4_HUMAN
NC score	0.052539 (rank : 260)	θ value	θ > 10 (rank : 226)
Query Neighborhood Hits	96	Target Neighborhood Hits	905	Shared Neighborhood Hits	46
SwissProt Accessions	Q99466, O00306, Q99458, Q99940, Q9H3S8, Q9UII9, Q9UIJ0	Gene names	NOTCH4
Domain Architecture
Description	Neurogenic locus notch homolog protein 4 precursor (Notch 4) (hNotch4) [Contains: Notch 4 extracellular truncation; Notch 4 intracellular domain].

ELA2A_MOUSE
NC score	0.052261 (rank : 261)	θ value	θ > 10 (rank : 137)
Query Neighborhood Hits	96	Target Neighborhood Hits	178	Shared Neighborhood Hits	16
SwissProt Accessions	P05208	Gene names	Ela2a, Ela-2, Ela2
Domain Architecture
Description	Elastase-2A precursor (EC 3.4.21.71) (Elastase-2).

DLL4_HUMAN
NC score	0.052226 (rank : 262)	θ value	θ > 10 (rank : 131)
Query Neighborhood Hits	96	Target Neighborhood Hits	435	Shared Neighborhood Hits	39
SwissProt Accessions	Q9NR61, Q9NQT9	Gene names	DLL4
Domain Architecture
Description	Delta-like protein 4 precursor (Drosophila Delta homolog 4).

KRA53_HUMAN
NC score	0.051761 (rank : 263)	θ value	θ > 10 (rank : 183)
Query Neighborhood Hits	96	Target Neighborhood Hits	331	Shared Neighborhood Hits	22
SwissProt Accessions	Q6L8H2, Q6PL44, Q701N3	Gene names	KRTAP5-3, KAP5-9, KAP5.3, KRTAP5-9, KRTAP5.3, KRTAP5.9
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 5-3 (Keratin-associated protein 5.3) (Ultrahigh sulfur keratin-associated protein 5.3) (Keratin-associated protein 5-9) (Keratin-associated protein 5.9) (UHS KerB-like).

TRYB1_HUMAN
NC score	0.051680 (rank : 264)	θ value	θ > 10 (rank : 277)
Query Neighborhood Hits	96	Target Neighborhood Hits	175	Shared Neighborhood Hits	16
SwissProt Accessions	Q15661, Q15663, Q9H2Y4	Gene names	TPSAB1, TPSB1
Domain Architecture
Description	Tryptase beta-1 precursor (EC 3.4.21.59) (Tryptase-1) (Tryptase I).

TRYB2_HUMAN
NC score	0.051680 (rank : 265)	θ value	θ > 10 (rank : 279)
Query Neighborhood Hits	96	Target Neighborhood Hits	175	Shared Neighborhood Hits	16
SwissProt Accessions	P20231, O95827, Q15664, Q9UQI6, Q9UQI7	Gene names	TPSB2, TPS2
Domain Architecture
Description	Tryptase beta-2 precursor (EC 3.4.21.59) (Tryptase-2) (Tryptase II).

SREC2_MOUSE
NC score	0.051593 (rank : 266)	θ value	θ > 10 (rank : 243)
Query Neighborhood Hits	96	Target Neighborhood Hits	605	Shared Neighborhood Hits	31
SwissProt Accessions	P59222	Gene names	Scarf2, Srec2
Domain Architecture	No domain graphic available
Description	Scavenger receptor class F member 2 precursor (Scavenger receptor expressed by endothelial cells 2 protein) (SREC-II).

HPT_MOUSE
NC score	0.051569 (rank : 267)	θ value	θ > 10 (rank : 173)
Query Neighborhood Hits	96	Target Neighborhood Hits	178	Shared Neighborhood Hits	16
SwissProt Accessions	Q61646	Gene names	Hp
Domain Architecture
Description	Haptoglobin precursor [Contains: Haptoglobin alpha chain; Haptoglobin beta chain].

TRYB1_MOUSE
NC score	0.051548 (rank : 268)	θ value	θ > 10 (rank : 278)
Query Neighborhood Hits	96	Target Neighborhood Hits	175	Shared Neighborhood Hits	16
SwissProt Accessions	Q02844	Gene names	Tpsab1, Mcpt7
Domain Architecture
Description	Tryptase precursor (EC 3.4.21.59) (Mast cell protease 7) (MMCP-7) (Tryptase alpha/beta-1).

TRYA1_HUMAN
NC score	0.051528 (rank : 269)	θ value	θ > 10 (rank : 276)
Query Neighborhood Hits	96	Target Neighborhood Hits	177	Shared Neighborhood Hits	16
SwissProt Accessions	P15157, Q9H2Y5, Q9UQI1	Gene names	TPSAB1, TPS1
Domain Architecture
Description	Tryptase alpha-1 precursor (EC 3.4.21.59) (Tryptase-1).

UROM_HUMAN
NC score	0.051384 (rank : 270)	θ value	θ > 10 (rank : 286)
Query Neighborhood Hits	96	Target Neighborhood Hits	284	Shared Neighborhood Hits	25
SwissProt Accessions	P07911, Q540J6, Q6ZS84, Q8IYG0	Gene names	UMOD
Domain Architecture
Description	Uromodulin precursor (Tamm-Horsfall urinary glycoprotein) (THP).

NETR_MOUSE
NC score	0.051382 (rank : 271)	θ value	θ > 10 (rank : 217)
Query Neighborhood Hits	96	Target Neighborhood Hits	216	Shared Neighborhood Hits	16
SwissProt Accessions	O08762	Gene names	Prss12, Bssp3
Domain Architecture
Description	Neurotrypsin precursor (EC 3.4.21.-) (Motopsin) (Brain-specific serine protease 3) (BSSP-3).

PTGDS_HUMAN
NC score	0.051376 (rank : 272)	θ value	θ > 10 (rank : 239)
Query Neighborhood Hits	96	Target Neighborhood Hits	31	Shared Neighborhood Hits	2
SwissProt Accessions	P41222, Q5SQ10, Q7M4P3, Q9UCC9, Q9UCD9	Gene names	PTGDS, PDS
Domain Architecture
Description	Prostaglandin-H2 D-isomerase precursor (EC 5.3.99.2) (Lipocalin-type prostaglandin-D synthase) (Glutathione-independent PGD synthetase) (Prostaglandin-D2 synthase) (PGD2 synthase) (PGDS2) (PGDS) (Beta-trace protein) (Cerebrin-28).

ELA2A_HUMAN
NC score	0.051335 (rank : 273)	θ value	θ > 10 (rank : 136)
Query Neighborhood Hits	96	Target Neighborhood Hits	180	Shared Neighborhood Hits	16
SwissProt Accessions	P08217, Q14243	Gene names	ELA2A
Domain Architecture
Description	Elastase-2A precursor (EC 3.4.21.71).

DLL4_MOUSE
NC score	0.051297 (rank : 274)	θ value	θ > 10 (rank : 132)
Query Neighborhood Hits	96	Target Neighborhood Hits	440	Shared Neighborhood Hits	34
SwissProt Accessions	Q9JI71, Q9JHZ7	Gene names	Dll4
Domain Architecture
Description	Delta-like protein 4 precursor (Drosophila Delta homolog 4).

THRB_HUMAN
NC score	0.051056 (rank : 275)	θ value	θ > 10 (rank : 253)
Query Neighborhood Hits	96	Target Neighborhood Hits	196	Shared Neighborhood Hits	16
SwissProt Accessions	P00734	Gene names	F2
Domain Architecture
Description	Prothrombin precursor (EC 3.4.21.5) (Coagulation factor II) [Contains: Activation peptide fragment 1; Activation peptide fragment 2; Thrombin light chain; Thrombin heavy chain].

ELA2B_HUMAN
NC score	0.050866 (rank : 276)	θ value	θ > 10 (rank : 138)
Query Neighborhood Hits	96	Target Neighborhood Hits	178	Shared Neighborhood Hits	16
SwissProt Accessions	P08218	Gene names	ELA2B
Domain Architecture
Description	Elastase-2B precursor (EC 3.4.21.71).

UROM_MOUSE
NC score	0.050795 (rank : 277)	θ value	θ > 10 (rank : 287)
Query Neighborhood Hits	96	Target Neighborhood Hits	276	Shared Neighborhood Hits	25
SwissProt Accessions	Q91X17, Q3TN64, Q3TP60, Q62285	Gene names	Umod
Domain Architecture	No domain graphic available
Description	Uromodulin precursor (Tamm-Horsfall urinary glycoprotein) (THP).

KRA59_HUMAN
NC score	0.050643 (rank : 278)	θ value	θ > 10 (rank : 184)
Query Neighborhood Hits	96	Target Neighborhood Hits	310	Shared Neighborhood Hits	20
SwissProt Accessions	P26371, Q14564	Gene names	KRTAP5-9, KAP5.9, KRN1, KRTAP5.9, UHSK1
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 5-9 (Keratin-associated protein 5.9) (Ultrahigh sulfur keratin-associated protein 5.9) (Keratin, cuticle, ultrahigh sulfur 1) (Keratin, ultra high-sulfur matrix protein A) (UHS keratin A) (UHS KerA).

NETR_HUMAN
NC score	0.050609 (rank : 279)	θ value	θ > 10 (rank : 216)
Query Neighborhood Hits	96	Target Neighborhood Hits	218	Shared Neighborhood Hits	16
SwissProt Accessions	P56730, Q9UP16	Gene names	PRSS12
Domain Architecture
Description	Neurotrypsin precursor (EC 3.4.21.-) (Motopsin) (Leydin).

TRYD_HUMAN
NC score	0.050592 (rank : 280)	θ value	θ > 10 (rank : 280)
Query Neighborhood Hits	96	Target Neighborhood Hits	175	Shared Neighborhood Hits	16
SwissProt Accessions	Q9BZJ3, O95824, Q8TDI6, Q96L36, Q96RZ5, Q9H2Y6, Q9UQI8	Gene names	TPSD1
Domain Architecture
Description	Tryptase delta precursor (EC 3.4.21.59) (Delta tryptase) (Mast cell mMCP-7-like) (Tryptase-3) (HmMCP-3-like tryptase III).

THRB_MOUSE
NC score	0.050203 (rank : 281)	θ value	θ > 10 (rank : 254)
Query Neighborhood Hits	96	Target Neighborhood Hits	195	Shared Neighborhood Hits	16
SwissProt Accessions	P19221	Gene names	F2, Cf2
Domain Architecture
Description	Prothrombin precursor (EC 3.4.21.5) (Coagulation factor II) [Contains: Activation peptide fragment 1; Activation peptide fragment 2; Thrombin light chain; Thrombin heavy chain].

ELA3B_HUMAN
NC score	0.050199 (rank : 282)	θ value	θ > 10 (rank : 139)
Query Neighborhood Hits	96	Target Neighborhood Hits	175	Shared Neighborhood Hits	16
SwissProt Accessions	P08861, P11423, Q5VU28, Q5VU29, Q5VU30	Gene names	ELA3B
Domain Architecture
Description	Elastase-3B precursor (EC 3.4.21.70) (Elastase IIIB) (Protease E).

ELTD1_MOUSE
NC score	0.048285 (rank : 283)	θ value	1.38821 (rank : 78)
Query Neighborhood Hits	96	Target Neighborhood Hits	288	Shared Neighborhood Hits	20
SwissProt Accessions	Q923X1, Q91W44	Gene names	Eltd1
Domain Architecture
Description	EGF, latrophilin seven transmembrane domain-containing protein 1 precursor.

TEX2_HUMAN
NC score	0.027028 (rank : 284)	θ value	1.06291 (rank : 75)
Query Neighborhood Hits	96	Target Neighborhood Hits	106	Shared Neighborhood Hits	2
SwissProt Accessions	Q8IWB9, Q6AHZ5, Q8N3L0, Q9C0C5	Gene names	TEX2, KIAA1738
Domain Architecture	No domain graphic available
Description	Testis-expressed sequence 2 protein.

ALK_MOUSE
NC score	0.008913 (rank : 285)	θ value	4.03905 (rank : 84)
Query Neighborhood Hits	96	Target Neighborhood Hits	811	Shared Neighborhood Hits	29
SwissProt Accessions	P97793	Gene names	Alk
Domain Architecture
Description	ALK tyrosine kinase receptor precursor (EC 2.7.10.1) (Anaplastic lymphoma kinase) (CD246 antigen).

ERBB3_MOUSE
NC score	0.004979 (rank : 286)	θ value	1.38821 (rank : 79)
Query Neighborhood Hits	96	Target Neighborhood Hits	898	Shared Neighborhood Hits	12
SwissProt Accessions	Q61526, Q3KQR1, Q68J64, Q810U8, Q8K317	Gene names	Erbb3
Domain Architecture	No domain graphic available
Description	Receptor tyrosine-protein kinase erbB-3 precursor (EC 2.7.10.1) (c- erbB3) (Glial growth factor receptor).

CAD12_HUMAN
NC score	0.003025 (rank : 287)	θ value	4.03905 (rank : 85)
Query Neighborhood Hits	96	Target Neighborhood Hits	154	Shared Neighborhood Hits	3
SwissProt Accessions	P55289	Gene names	CDH12
Domain Architecture
Description	Cadherin-12 precursor (Brain-cadherin) (BR-cadherin) (N-cadherin 2) (Neural type cadherin 2).

CAD10_HUMAN
NC score	0.002673 (rank : 288)	θ value	5.27518 (rank : 91)
Query Neighborhood Hits	96	Target Neighborhood Hits	162	Shared Neighborhood Hits	3
SwissProt Accessions	Q9Y6N8, Q9ULB3	Gene names	CDH10
Domain Architecture
Description	Cadherin-10 precursor (T2-cadherin).

GNAS1_MOUSE
NC score	0.002199 (rank : 289)	θ value	6.88961 (rank : 93)
Query Neighborhood Hits	96	Target Neighborhood Hits	651	Shared Neighborhood Hits	4
SwissProt Accessions	Q6R0H7, Q6R0H4, Q6R0H5, Q6R2J5, Q9JJX0, Q9Z1N8	Gene names	Gnas, Gnas1
Domain Architecture	No domain graphic available
Description	Guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas (Adenylate cyclase-stimulating G alpha protein) (Extra large alphas protein) (XLalphas).