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Network neighborhood for query Sequence : CR001_HUMAN

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CR001_HUMAN
SwissProt Accessions	O15165, O15166, O15167, O15168, Q6NXP3	Gene names	C18orf1
Domain Architecture
Description	Protein C18orf1.
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

CR001_HUMAN
θ value	6.35588e-163 (rank : 1)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	68	Target Neighborhood Hits	68	Shared Neighborhood Hits	68
SwissProt Accessions	O15165, O15166, O15167, O15168, Q6NXP3	Gene names	C18orf1
Domain Architecture
Description	Protein C18orf1.

CR001_MOUSE
θ value	4.26331e-159 (rank : 2)	NC score	0.994703 (rank : 2)
Query Neighborhood Hits	68	Target Neighborhood Hits	67	Shared Neighborhood Hits	59
SwissProt Accessions	Q8BWJ4	Gene names	D18Ertd653e
Domain Architecture	No domain graphic available
Description	Protein C18orf1 homolog.

TMEPA_HUMAN
θ value	3.56943e-81 (rank : 3)	NC score	0.886250 (rank : 4)
Query Neighborhood Hits	68	Target Neighborhood Hits	46	Shared Neighborhood Hits	11
SwissProt Accessions	Q969W9, Q5TDR6, Q96B72, Q9UJD3	Gene names	TMEPAI, PMEPA1, STAG1
Domain Architecture
Description	Transmembrane prostate androgen-induced protein (Solid tumor- associated 1 protein).

TMEPA_MOUSE
θ value	1.95861e-79 (rank : 4)	NC score	0.890232 (rank : 3)
Query Neighborhood Hits	68	Target Neighborhood Hits	46	Shared Neighborhood Hits	10
SwissProt Accessions	Q9D7R2, Q9EQH9	Gene names	Tmepai, N4wbp4
Domain Architecture	No domain graphic available
Description	Transmembrane prostate androgen-induced protein (NEDD4 WW domain- binding protein 4).

SSPO_MOUSE
θ value	9.29e-05 (rank : 5)	NC score	0.219731 (rank : 35)
Query Neighborhood Hits	68	Target Neighborhood Hits	800	Shared Neighborhood Hits	56
SwissProt Accessions	Q8CG65	Gene names	Sspo
Domain Architecture	No domain graphic available
Description	SCO-spondin precursor.

CO6_HUMAN
θ value	0.000121331 (rank : 6)	NC score	0.245451 (rank : 31)
Query Neighborhood Hits	68	Target Neighborhood Hits	331	Shared Neighborhood Hits	55
SwissProt Accessions	P13671	Gene names	C6
Domain Architecture
Description	Complement component C6 precursor.

LRP2_HUMAN
θ value	0.00020696 (rank : 7)	NC score	0.284353 (rank : 22)
Query Neighborhood Hits	68	Target Neighborhood Hits	573	Shared Neighborhood Hits	54
SwissProt Accessions	P98164, O00711, Q16215	Gene names	LRP2
Domain Architecture
Description	Low-density lipoprotein receptor-related protein 2 precursor (Megalin) (Glycoprotein 330) (gp330).

LRP4_MOUSE
θ value	0.000602161 (rank : 8)	NC score	0.289603 (rank : 16)
Query Neighborhood Hits	68	Target Neighborhood Hits	351	Shared Neighborhood Hits	53
SwissProt Accessions	Q8VI56, Q8BPX5, Q8CBB3, Q8CCP5	Gene names	Lrp4, Kiaa0816
Domain Architecture
Description	Low-density lipoprotein receptor-related protein 4 precursor (LDLR dan).

LRP1_HUMAN
θ value	0.000786445 (rank : 9)	NC score	0.262814 (rank : 29)
Query Neighborhood Hits	68	Target Neighborhood Hits	617	Shared Neighborhood Hits	55
SwissProt Accessions	Q07954, Q2PP12, Q8IVG8	Gene names	LRP1, A2MR
Domain Architecture
Description	Low-density lipoprotein receptor-related protein 1 precursor (LRP) (Alpha-2-macroglobulin receptor) (A2MR) (Apolipoprotein E receptor) (APOER) (CD91 antigen).

LRP4_HUMAN
θ value	0.000786445 (rank : 10)	NC score	0.289933 (rank : 15)
Query Neighborhood Hits	68	Target Neighborhood Hits	355	Shared Neighborhood Hits	53
SwissProt Accessions	O75096	Gene names	LRP4, KIAA0816, MEGF7
Domain Architecture
Description	Low-density lipoprotein receptor-related protein 4 precursor (Multiple epidermal growth factor-like domains 7).

CORIN_MOUSE
θ value	0.00102713 (rank : 11)	NC score	0.174344 (rank : 39)
Query Neighborhood Hits	68	Target Neighborhood Hits	451	Shared Neighborhood Hits	51
SwissProt Accessions	Q9Z319	Gene names	Corin, Crn, Lrp4
Domain Architecture
Description	Atrial natriuteric peptide-converting enzyme (EC 3.4.21.-) (pro-ANP- converting enzyme) (Corin) (Low density lipoprotein receptor-related protein 4).

LRP12_HUMAN
θ value	0.00102713 (rank : 12)	NC score	0.289346 (rank : 18)
Query Neighborhood Hits	68	Target Neighborhood Hits	205	Shared Neighborhood Hits	52
SwissProt Accessions	Q9Y561	Gene names	LRP12, ST7
Domain Architecture
Description	Low-density lipoprotein receptor-related protein 12 precursor (Suppressor of tumorigenicity protein 7).

LRP12_MOUSE
θ value	0.00102713 (rank : 13)	NC score	0.289407 (rank : 17)
Query Neighborhood Hits	68	Target Neighborhood Hits	180	Shared Neighborhood Hits	51
SwissProt Accessions	Q8BUJ9, Q8BWM9	Gene names	Lrp12
Domain Architecture
Description	Low-density lipoprotein receptor-related protein 12 precursor.

CORIN_HUMAN
θ value	0.00134147 (rank : 14)	NC score	0.174376 (rank : 38)
Query Neighborhood Hits	68	Target Neighborhood Hits	453	Shared Neighborhood Hits	51
SwissProt Accessions	Q9Y5Q5, Q9UHY2	Gene names	CORIN, CRN, TMPRSS10
Domain Architecture
Description	Atrial natriuteric peptide-converting enzyme (EC 3.4.21.-) (pro-ANP- converting enzyme) (Corin) (Heart-specific serine proteinase ATC2) (Transmembrane protease, serine 10).

LRP3_HUMAN
θ value	0.00134147 (rank : 15)	NC score	0.312450 (rank : 8)
Query Neighborhood Hits	68	Target Neighborhood Hits	280	Shared Neighborhood Hits	52
SwissProt Accessions	O75074	Gene names	LRP3
Domain Architecture
Description	Low-density lipoprotein receptor-related protein 3 precursor (hLRp105).

LRP1B_HUMAN
θ value	0.00175202 (rank : 16)	NC score	0.262403 (rank : 30)
Query Neighborhood Hits	68	Target Neighborhood Hits	602	Shared Neighborhood Hits	54
SwissProt Accessions	Q9NZR2, Q8WY29, Q8WY30, Q8WY31	Gene names	LRP1B, LRPDIT
Domain Architecture
Description	Low-density lipoprotein receptor-related protein 1B precursor (Low- density lipoprotein receptor-related protein-deleted in tumor) (LRP- DIT).

LRP1B_MOUSE
θ value	0.00175202 (rank : 17)	NC score	0.262981 (rank : 28)
Query Neighborhood Hits	68	Target Neighborhood Hits	606	Shared Neighborhood Hits	55
SwissProt Accessions	Q9JI18, Q8BZD3, Q8BZM7	Gene names	Lrp1b, Lrpdit
Domain Architecture
Description	Low-density lipoprotein receptor-related protein 1B precursor (Low- density lipoprotein receptor-related protein-deleted in tumor) (LRP- DIT).

LRP8_MOUSE
θ value	0.00228821 (rank : 18)	NC score	0.282565 (rank : 23)
Query Neighborhood Hits	68	Target Neighborhood Hits	385	Shared Neighborhood Hits	52
SwissProt Accessions	Q924X6, Q8CAK9, Q8CDF5, Q921B6	Gene names	Lrp8, Apoer2
Domain Architecture
Description	Low-density lipoprotein receptor-related protein 8 precursor (Apolipoprotein E receptor 2).

VLDLR_HUMAN
θ value	0.00228821 (rank : 19)	NC score	0.288996 (rank : 19)
Query Neighborhood Hits	68	Target Neighborhood Hits	383	Shared Neighborhood Hits	54
SwissProt Accessions	P98155, Q5VVF6	Gene names	VLDLR
Domain Architecture
Description	Very low-density lipoprotein receptor precursor (VLDL receptor) (VLDL- R).

CO9_HUMAN
θ value	0.00390308 (rank : 20)	NC score	0.314248 (rank : 7)
Query Neighborhood Hits	68	Target Neighborhood Hits	147	Shared Neighborhood Hits	52
SwissProt Accessions	P02748	Gene names	C9
Domain Architecture
Description	Complement component C9 precursor [Contains: Complement component C9a; Complement component C9b].

ST14_MOUSE
θ value	0.00390308 (rank : 21)	NC score	0.168330 (rank : 41)
Query Neighborhood Hits	68	Target Neighborhood Hits	419	Shared Neighborhood Hits	51
SwissProt Accessions	P56677	Gene names	St14, Prss14
Domain Architecture
Description	Suppressor of tumorigenicity protein 14 (EC 3.4.21.-) (Serine protease 14) (Epithin).

VLDLR_MOUSE
θ value	0.00390308 (rank : 22)	NC score	0.286376 (rank : 21)
Query Neighborhood Hits	68	Target Neighborhood Hits	360	Shared Neighborhood Hits	54
SwissProt Accessions	P98156, Q64022	Gene names	Vldlr
Domain Architecture
Description	Very low-density lipoprotein receptor precursor (VLDL receptor) (VLDL- R).

LDLR_MOUSE
θ value	0.00509761 (rank : 23)	NC score	0.287315 (rank : 20)
Query Neighborhood Hits	68	Target Neighborhood Hits	382	Shared Neighborhood Hits	53
SwissProt Accessions	P35951	Gene names	Ldlr
Domain Architecture
Description	Low-density lipoprotein receptor precursor (LDL receptor).

LRP6_HUMAN
θ value	0.00869519 (rank : 24)	NC score	0.304261 (rank : 11)
Query Neighborhood Hits	68	Target Neighborhood Hits	235	Shared Neighborhood Hits	52
SwissProt Accessions	O75581	Gene names	LRP6
Domain Architecture
Description	Low-density lipoprotein receptor-related protein 6 precursor.

LRP6_MOUSE
θ value	0.00869519 (rank : 25)	NC score	0.304713 (rank : 10)
Query Neighborhood Hits	68	Target Neighborhood Hits	232	Shared Neighborhood Hits	52
SwissProt Accessions	O88572	Gene names	Lrp6
Domain Architecture
Description	Low-density lipoprotein receptor-related protein 6 precursor.

CO9_MOUSE
θ value	0.0113563 (rank : 26)	NC score	0.295447 (rank : 12)
Query Neighborhood Hits	68	Target Neighborhood Hits	153	Shared Neighborhood Hits	51
SwissProt Accessions	P06683, Q91XA7	Gene names	C9
Domain Architecture
Description	Complement component C9 precursor.

LDLR_HUMAN
θ value	0.0113563 (rank : 27)	NC score	0.279598 (rank : 25)
Query Neighborhood Hits	68	Target Neighborhood Hits	375	Shared Neighborhood Hits	53
SwissProt Accessions	P01130, Q53ZD9	Gene names	LDLR
Domain Architecture
Description	Low-density lipoprotein receptor precursor (LDL receptor).

ST14_HUMAN
θ value	0.0113563 (rank : 28)	NC score	0.167090 (rank : 42)
Query Neighborhood Hits	68	Target Neighborhood Hits	409	Shared Neighborhood Hits	51
SwissProt Accessions	Q9Y5Y6, Q9BS01, Q9H3S0, Q9HB36, Q9HCA3	Gene names	ST14, PRSS14, SNC19, TADG15
Domain Architecture
Description	Suppressor of tumorigenicity protein 14 (EC 3.4.21.-) (Serine protease 14) (Matriptase) (Membrane-type serine protease 1) (MT-SP1) (Prostamin) (Serine protease TADG-15) (Tumor-associated differentially-expressed gene 15 protein).

LRP8_HUMAN
θ value	0.0193708 (rank : 29)	NC score	0.282025 (rank : 24)
Query Neighborhood Hits	68	Target Neighborhood Hits	346	Shared Neighborhood Hits	53
SwissProt Accessions	Q14114, O14968, Q86V27, Q99876, Q9BR78	Gene names	LRP8, APOER2
Domain Architecture
Description	Low-density lipoprotein receptor-related protein 8 precursor (Apolipoprotein E receptor 2).

SORL_MOUSE
θ value	0.0193708 (rank : 30)	NC score	0.271863 (rank : 26)
Query Neighborhood Hits	68	Target Neighborhood Hits	439	Shared Neighborhood Hits	53
SwissProt Accessions	O88307, O54711, O70581	Gene names	Sorl1
Domain Architecture
Description	Sortilin-related receptor precursor (Sorting protein-related receptor containing LDLR class A repeats) (mSorLA) (SorLA-1) (Low-density lipoprotein receptor relative with 11 ligand-binding repeats) (LDLR relative with 11 ligand-binding repeats) (LR11) (Gp250).

LRP10_HUMAN
θ value	0.0252991 (rank : 31)	NC score	0.319069 (rank : 6)
Query Neighborhood Hits	68	Target Neighborhood Hits	197	Shared Neighborhood Hits	52
SwissProt Accessions	Q7Z4F1, O95882, Q86T02, Q8NCZ4, Q9HC42, Q9UG33	Gene names	LRP10
Domain Architecture
Description	Low-density lipoprotein receptor-related protein 10 precursor.

CO8B_HUMAN
θ value	0.0431538 (rank : 32)	NC score	0.234655 (rank : 32)
Query Neighborhood Hits	68	Target Neighborhood Hits	199	Shared Neighborhood Hits	51
SwissProt Accessions	P07358	Gene names	C8B
Domain Architecture
Description	Complement component C8 beta chain precursor (Complement component 8 subunit beta).

CO8B_MOUSE
θ value	0.0431538 (rank : 33)	NC score	0.227941 (rank : 33)
Query Neighborhood Hits	68	Target Neighborhood Hits	224	Shared Neighborhood Hits	52
SwissProt Accessions	Q8BH35, Q4VAH1, Q8CHJ5, Q8CHJ6, Q8VC14	Gene names	C8b
Domain Architecture	No domain graphic available
Description	Complement component C8 beta chain precursor (Complement component 8 subunit beta).

SORL_HUMAN
θ value	0.0431538 (rank : 34)	NC score	0.270490 (rank : 27)
Query Neighborhood Hits	68	Target Neighborhood Hits	440	Shared Neighborhood Hits	52
SwissProt Accessions	Q92673, Q92856	Gene names	SORL1
Domain Architecture
Description	Sortilin-related receptor precursor (Sorting protein-related receptor containing LDLR class A repeats) (SorLA) (SorLA-1) (Low-density lipoprotein receptor relative with 11 ligand-binding repeats) (LDLR relative with 11 ligand-binding repeats) (LR11).

LRP10_MOUSE
θ value	0.125558 (rank : 35)	NC score	0.310001 (rank : 9)
Query Neighborhood Hits	68	Target Neighborhood Hits	169	Shared Neighborhood Hits	51
SwissProt Accessions	Q7TQH7, Q7TS95, Q921T0, Q9EPE8	Gene names	Lrp10, Lrp9
Domain Architecture
Description	Low-density lipoprotein receptor-related protein 10 precursor.

CD320_HUMAN
θ value	0.21417 (rank : 36)	NC score	0.348844 (rank : 5)
Query Neighborhood Hits	68	Target Neighborhood Hits	103	Shared Neighborhood Hits	51
SwissProt Accessions	Q9NPF0, Q53HF7	Gene names	CD320, 8D6A
Domain Architecture	No domain graphic available
Description	CD320 antigen precursor (8D6 antigen) (FDC-signaling molecule 8D6) (FDC-SM-8D6).

CO7_HUMAN
θ value	0.21417 (rank : 37)	NC score	0.196091 (rank : 37)
Query Neighborhood Hits	68	Target Neighborhood Hits	278	Shared Neighborhood Hits	52
SwissProt Accessions	P10643, Q6P3T5, Q92489	Gene names	C7
Domain Architecture
Description	Complement component C7 precursor.

LRP5_MOUSE
θ value	0.47712 (rank : 38)	NC score	0.294081 (rank : 13)
Query Neighborhood Hits	68	Target Neighborhood Hits	236	Shared Neighborhood Hits	51
SwissProt Accessions	Q91VN0, O88883, Q9R208	Gene names	Lrp5, Lrp7
Domain Architecture
Description	Low-density lipoprotein receptor-related protein 5 precursor (LRP7) (Lr3).

MINT_HUMAN
θ value	0.47712 (rank : 39)	NC score	0.036312 (rank : 164)
Query Neighborhood Hits	68	Target Neighborhood Hits	1291	Shared Neighborhood Hits	9
SwissProt Accessions	Q96T58, Q9H9A8, Q9NWH5, Q9UQ01, Q9Y556	Gene names	SPEN, KIAA0929, MINT, SHARP
Domain Architecture
Description	Msx2-interacting protein (SPEN homolog) (SMART/HDAC1-associated repressor protein).

MINT_MOUSE
θ value	0.47712 (rank : 40)	NC score	0.035067 (rank : 166)
Query Neighborhood Hits	68	Target Neighborhood Hits	1514	Shared Neighborhood Hits	10
SwissProt Accessions	Q62504, Q80TN9, Q99PS4, Q9QZW2	Gene names	Spen, Kiaa0929, Mint, Sharp
Domain Architecture
Description	Msx2-interacting protein (SPEN homolog) (SMART/HDAC1-associated repressor protein).

CO8A_MOUSE
θ value	0.62314 (rank : 41)	NC score	0.226259 (rank : 34)
Query Neighborhood Hits	68	Target Neighborhood Hits	182	Shared Neighborhood Hits	52
SwissProt Accessions	Q8K182, Q8CHJ9, Q8CHK1	Gene names	C8a
Domain Architecture	No domain graphic available
Description	Complement component C8 alpha chain precursor (Complement component 8 subunit alpha).

ENTK_MOUSE
θ value	0.62314 (rank : 42)	NC score	0.093224 (rank : 66)
Query Neighborhood Hits	68	Target Neighborhood Hits	338	Shared Neighborhood Hits	50
SwissProt Accessions	P97435	Gene names	Prss7, Entk
Domain Architecture
Description	Enteropeptidase (EC 3.4.21.9) (Enterokinase) [Contains: Enteropeptidase non-catalytic heavy chain; Enteropeptidase catalytic light chain].

GAB1_MOUSE
θ value	0.62314 (rank : 43)	NC score	0.070299 (rank : 73)
Query Neighborhood Hits	68	Target Neighborhood Hits	233	Shared Neighborhood Hits	10
SwissProt Accessions	Q9QYY0, Q91VW7	Gene names	Gab1
Domain Architecture
Description	GRB2-associated-binding protein 1 (GRB2-associated binder 1).

TMPS9_HUMAN
θ value	0.62314 (rank : 44)	NC score	0.085393 (rank : 67)
Query Neighborhood Hits	68	Target Neighborhood Hits	276	Shared Neighborhood Hits	49
SwissProt Accessions	Q7Z410, Q6ZND6, Q7Z411	Gene names	TMPRSS9
Domain Architecture	No domain graphic available
Description	Transmembrane protease, serine 9 (EC 3.4.21.-) (Polyserase-1) (Polyserase-I) (Polyserine protease 1) [Contains: Serase-1; Serase-2; Serase-3].

TMPS9_MOUSE
θ value	0.62314 (rank : 45)	NC score	0.083327 (rank : 69)
Query Neighborhood Hits	68	Target Neighborhood Hits	296	Shared Neighborhood Hits	51
SwissProt Accessions	P69525	Gene names	Tmprss9
Domain Architecture	No domain graphic available
Description	Transmembrane protease, serine 9 (EC 3.4.21.-) (Polyserase-1) (Polyserine protease 1) (Polyserase-I) [Contains: Serase-1; Serase-2; Serase-3].

CO8A_HUMAN
θ value	1.06291 (rank : 46)	NC score	0.217326 (rank : 36)
Query Neighborhood Hits	68	Target Neighborhood Hits	200	Shared Neighborhood Hits	52
SwissProt Accessions	P07357, Q13668, Q9H130	Gene names	C8A
Domain Architecture
Description	Complement component C8 alpha chain precursor (Complement component 8 subunit alpha).

PGBM_HUMAN
θ value	1.06291 (rank : 47)	NC score	0.114647 (rank : 60)
Query Neighborhood Hits	68	Target Neighborhood Hits	1113	Shared Neighborhood Hits	55
SwissProt Accessions	P98160, Q16287, Q9H3V5	Gene names	HSPG2
Domain Architecture
Description	Basement membrane-specific heparan sulfate proteoglycan core protein precursor (HSPG) (Perlecan) (PLC).

CFAI_MOUSE
θ value	1.38821 (rank : 48)	NC score	0.118964 (rank : 56)
Query Neighborhood Hits	68	Target Neighborhood Hits	290	Shared Neighborhood Hits	51
SwissProt Accessions	Q61129, Q9WU07	Gene names	Cfi, If
Domain Architecture
Description	Complement factor I precursor (EC 3.4.21.45) (C3B/C4B inactivator) [Contains: Complement factor I heavy chain; Complement factor I light chain].

LRP5_HUMAN
θ value	1.81305 (rank : 49)	NC score	0.290574 (rank : 14)
Query Neighborhood Hits	68	Target Neighborhood Hits	224	Shared Neighborhood Hits	51
SwissProt Accessions	O75197, Q96TD6, Q9UP66	Gene names	LRP5, LRP7
Domain Architecture
Description	Low-density lipoprotein receptor-related protein 5 precursor.

PGBM_MOUSE
θ value	1.81305 (rank : 50)	NC score	0.119887 (rank : 55)
Query Neighborhood Hits	68	Target Neighborhood Hits	1073	Shared Neighborhood Hits	53
SwissProt Accessions	Q05793	Gene names	Hspg2
Domain Architecture
Description	Basement membrane-specific heparan sulfate proteoglycan core protein precursor (HSPG) (Perlecan) (PLC).

TMPS6_MOUSE
θ value	1.81305 (rank : 51)	NC score	0.118582 (rank : 57)
Query Neighborhood Hits	68	Target Neighborhood Hits	341	Shared Neighborhood Hits	51
SwissProt Accessions	Q9DBI0, Q6PF94	Gene names	Tmprss6
Domain Architecture
Description	Transmembrane protease, serine 6 (EC 3.4.21.-) (Matriptase-2).

TMPS7_MOUSE
θ value	1.81305 (rank : 52)	NC score	0.131370 (rank : 50)
Query Neighborhood Hits	68	Target Neighborhood Hits	275	Shared Neighborhood Hits	51
SwissProt Accessions	Q8BIK6	Gene names	Tmprss7
Domain Architecture	No domain graphic available
Description	Transmembrane protease, serine 7 precursor (EC 3.4.21.-).

PDZD8_HUMAN
θ value	2.36792 (rank : 53)	NC score	0.057634 (rank : 112)
Query Neighborhood Hits	68	Target Neighborhood Hits	185	Shared Neighborhood Hits	5
SwissProt Accessions	Q8NEN9, Q86WE0, Q86WE5, Q9UFF1	Gene names	PDZD8, PDZK8
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 8 (Sarcoma antigen NY-SAR-84/NY-SAR- 104).

5NT1B_MOUSE
θ value	3.0926 (rank : 54)	NC score	0.021115 (rank : 168)
Query Neighborhood Hits	68	Target Neighborhood Hits	78	Shared Neighborhood Hits	3
SwissProt Accessions	Q91YE9, Q91Y48	Gene names	Nt5c1b, Airp
Domain Architecture
Description	Cytosolic 5'-nucleotidase 1B (EC 3.1.3.5) (Cytosolic 5'-nucleotidase IB) (cN1B) (cN-IB) (Autoimmune infertility-related protein).

CASR_MOUSE
θ value	3.0926 (rank : 55)	NC score	0.009621 (rank : 174)
Query Neighborhood Hits	68	Target Neighborhood Hits	72	Shared Neighborhood Hits	4
SwissProt Accessions	Q9QY96, O08968, O88519, Q9QY95, Q9QZU8, Q9R1D6, Q9R1Y2	Gene names	Casr, Gprc2a
Domain Architecture
Description	Extracellular calcium-sensing receptor precursor (CaSR) (Parathyroid Cell calcium-sensing receptor).

CFAI_HUMAN
θ value	4.03905 (rank : 56)	NC score	0.122698 (rank : 53)
Query Neighborhood Hits	68	Target Neighborhood Hits	289	Shared Neighborhood Hits	51
SwissProt Accessions	P05156, O60442	Gene names	CFI, IF
Domain Architecture
Description	Complement factor I precursor (EC 3.4.21.45) (C3B/C4B inactivator) [Contains: Complement factor I heavy chain; Complement factor I light chain].

GPR63_MOUSE
θ value	4.03905 (rank : 57)	NC score	0.001264 (rank : 175)
Query Neighborhood Hits	68	Target Neighborhood Hits	774	Shared Neighborhood Hits	2
SwissProt Accessions	Q9EQQ3	Gene names	Gpr63
Domain Architecture
Description	Probable G-protein coupled receptor 63 (PSP24-beta) (PSP24-2).

SPIT1_MOUSE
θ value	4.03905 (rank : 58)	NC score	0.145940 (rank : 47)
Query Neighborhood Hits	68	Target Neighborhood Hits	96	Shared Neighborhood Hits	50
SwissProt Accessions	Q9R097	Gene names	Spint1, Hai1
Domain Architecture
Description	Kunitz-type protease inhibitor 1 precursor (Hepatocyte growth factor activator inhibitor type 1) (HAI-1).

TMPS6_HUMAN
θ value	4.03905 (rank : 59)	NC score	0.121621 (rank : 54)
Query Neighborhood Hits	68	Target Neighborhood Hits	338	Shared Neighborhood Hits	51
SwissProt Accessions	Q8IU80, Q5TI06, Q6UXD8, Q8IUE2, Q8IXV8	Gene names	TMPRSS6
Domain Architecture
Description	Transmembrane protease, serine 6 (EC 3.4.21.-) (Matriptase-2).

ATS9_HUMAN
θ value	5.27518 (rank : 60)	NC score	0.025839 (rank : 167)
Query Neighborhood Hits	68	Target Neighborhood Hits	219	Shared Neighborhood Hits	19
SwissProt Accessions	Q9P2N4, Q9NR29	Gene names	ADAMTS9, KIAA1312
Domain Architecture
Description	ADAMTS-9 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase with thrombospondin motifs 9) (ADAM-TS 9) (ADAM-TS9).

GNAS3_MOUSE
θ value	5.27518 (rank : 61)	NC score	0.061009 (rank : 95)
Query Neighborhood Hits	68	Target Neighborhood Hits	84	Shared Neighborhood Hits	7
SwissProt Accessions	Q9Z0F1, Q9QXW5, Q9Z0H2	Gene names	Gnas, Gnas1
Domain Architecture	No domain graphic available
Description	Neuroendocrine secretory protein 55 (NESP55) [Contains: LHAL tetrapeptide; GPIPIRRH peptide].

MCP_MOUSE
θ value	5.27518 (rank : 62)	NC score	0.017796 (rank : 170)
Query Neighborhood Hits	68	Target Neighborhood Hits	79	Shared Neighborhood Hits	4
SwissProt Accessions	O88174, Q9R0R9	Gene names	Cd46, Mcp
Domain Architecture	No domain graphic available
Description	Membrane cofactor protein precursor (CD46 antigen).

SMAD4_MOUSE
θ value	5.27518 (rank : 63)	NC score	0.009630 (rank : 173)
Query Neighborhood Hits	68	Target Neighborhood Hits	101	Shared Neighborhood Hits	2
SwissProt Accessions	P97471, Q9CW56	Gene names	Smad4, Dpc4, Madh4
Domain Architecture
Description	Mothers against decapentaplegic homolog 4 (SMAD 4) (Mothers against DPP homolog 4) (Deletion target in pancreatic carcinoma 4 homolog) (Smad4).

CELR2_MOUSE
θ value	6.88961 (rank : 64)	NC score	0.013648 (rank : 172)
Query Neighborhood Hits	68	Target Neighborhood Hits	584	Shared Neighborhood Hits	18
SwissProt Accessions	Q9R0M0, Q99K26, Q9Z2R4	Gene names	Celsr2
Domain Architecture
Description	Cadherin EGF LAG seven-pass G-type receptor 2 precursor (Flamingo 1) (mFmi1).

GSCR1_HUMAN
θ value	6.88961 (rank : 65)	NC score	0.035836 (rank : 165)
Query Neighborhood Hits	68	Target Neighborhood Hits	674	Shared Neighborhood Hits	8
SwissProt Accessions	Q9NZM4	Gene names	GLTSCR1
Domain Architecture	No domain graphic available
Description	Glioma tumor suppressor candidate region gene 1 protein.

LRP11_MOUSE
θ value	6.88961 (rank : 66)	NC score	0.168885 (rank : 40)
Query Neighborhood Hits	68	Target Neighborhood Hits	81	Shared Neighborhood Hits	50
SwissProt Accessions	Q8CB67, Q8C7Y7	Gene names	Lrp11
Domain Architecture
Description	Low-density lipoprotein receptor-related protein 11 precursor.

CELR2_HUMAN
θ value	8.99809 (rank : 67)	NC score	0.018162 (rank : 169)
Query Neighborhood Hits	68	Target Neighborhood Hits	657	Shared Neighborhood Hits	26
SwissProt Accessions	Q9HCU4, Q92566	Gene names	CELSR2, CDHF10, EGFL2, KIAA0279, MEGF3
Domain Architecture
Description	Cadherin EGF LAG seven-pass G-type receptor 2 precursor (Epidermal growth factor-like 2) (Multiple epidermal growth factor-like domains 3) (Flamingo 1).

LPIN3_HUMAN
θ value	8.99809 (rank : 68)	NC score	0.014259 (rank : 171)
Query Neighborhood Hits	68	Target Neighborhood Hits	92	Shared Neighborhood Hits	4
SwissProt Accessions	Q9BQK8, Q5TDB9, Q9NPY8, Q9UJE5	Gene names	LPIN3, LIPN3L
Domain Architecture	No domain graphic available
Description	Lipin-3 (Lipin 3-like).

BMP1_HUMAN
θ value	θ > 10 (rank : 69)	NC score	0.055692 (rank : 121)
Query Neighborhood Hits	68	Target Neighborhood Hits	233	Shared Neighborhood Hits	28
SwissProt Accessions	P13497, Q13292, Q13872, Q14874, Q99421, Q99422, Q99423, Q9UL38	Gene names	BMP1, PCOLC
Domain Architecture
Description	Bone morphogenetic protein 1 precursor (EC 3.4.24.19) (BMP-1) (Procollagen C-proteinase) (PCP) (Mammalian tolloid protein) (mTld).

BMP1_MOUSE
θ value	θ > 10 (rank : 70)	NC score	0.055971 (rank : 117)
Query Neighborhood Hits	68	Target Neighborhood Hits	236	Shared Neighborhood Hits	28
SwissProt Accessions	P98063	Gene names	Bmp1
Domain Architecture
Description	Bone morphogenetic protein 1 precursor (EC 3.4.24.19) (BMP-1) (Procollagen C-proteinase) (PCP) (Mammalian tolloid protein) (mTld).

C1QR1_HUMAN
θ value	θ > 10 (rank : 71)	NC score	0.060293 (rank : 97)
Query Neighborhood Hits	68	Target Neighborhood Hits	493	Shared Neighborhood Hits	28
SwissProt Accessions	Q9NPY3, O00274	Gene names	CD93, C1QR1, MXRA4
Domain Architecture
Description	Complement component C1q receptor precursor (Complement component 1 q subcomponent receptor 1) (C1qR) (C1qRp) (C1qR(p)) (C1q/MBL/SPA receptor) (CD93 antigen) (CDw93).

C1QR1_MOUSE
θ value	θ > 10 (rank : 72)	NC score	0.056638 (rank : 114)
Query Neighborhood Hits	68	Target Neighborhood Hits	342	Shared Neighborhood Hits	24
SwissProt Accessions	O89103, Q3U2X0	Gene names	Cd93, Aa4, C1qr1, C1qrp, Ly68
Domain Architecture
Description	Complement component C1q receptor precursor (Complement component 1 q subcomponent receptor 1) (C1qRp) (C1qR(p)) (C1q/MBL/SPA receptor) (CD93 antigen) (Cell surface antigen AA4) (Lymphocyte antigen 68).

C1RA_MOUSE
θ value	θ > 10 (rank : 73)	NC score	0.052393 (rank : 144)
Query Neighborhood Hits	68	Target Neighborhood Hits	379	Shared Neighborhood Hits	35
SwissProt Accessions	Q8CG16, Q99KI6, Q9ET60	Gene names	C1ra, C1r
Domain Architecture
Description	Complement C1r-A subcomponent precursor (EC 3.4.21.41) (Complement component 1, r-A subcomponent) [Contains: Complement C1r-A subcomponent heavy chain; Complement C1r-A subcomponent light chain].

C1RB_MOUSE
θ value	θ > 10 (rank : 74)	NC score	0.051664 (rank : 150)
Query Neighborhood Hits	68	Target Neighborhood Hits	380	Shared Neighborhood Hits	34
SwissProt Accessions	Q8CFG9	Gene names	C1rb, C1r
Domain Architecture	No domain graphic available
Description	Complement C1r-B subcomponent precursor (EC 3.4.21.41) (Complement component 1, r-B subcomponent) [Contains: Complement C1r-B subcomponent heavy chain; Complement C1r-B subcomponent light chain].

C1R_HUMAN
θ value	θ > 10 (rank : 75)	NC score	0.051555 (rank : 152)
Query Neighborhood Hits	68	Target Neighborhood Hits	364	Shared Neighborhood Hits	32
SwissProt Accessions	P00736, Q8J012	Gene names	C1R
Domain Architecture
Description	Complement C1r subcomponent precursor (EC 3.4.21.41) (Complement component 1, r subcomponent) [Contains: Complement C1r subcomponent heavy chain; Complement C1r subcomponent light chain].

CD248_HUMAN
θ value	θ > 10 (rank : 76)	NC score	0.066665 (rank : 78)
Query Neighborhood Hits	68	Target Neighborhood Hits	679	Shared Neighborhood Hits	24
SwissProt Accessions	Q9HCU0, Q3SX55, Q96KB6	Gene names	CD248, CD164L1, TEM1
Domain Architecture	No domain graphic available
Description	Endosialin precursor (Tumor endothelial marker 1) (CD248 antigen).

CD248_MOUSE
θ value	θ > 10 (rank : 77)	NC score	0.067599 (rank : 77)
Query Neighborhood Hits	68	Target Neighborhood Hits	578	Shared Neighborhood Hits	23
SwissProt Accessions	Q91V98, Q3UMV6, Q91ZV1	Gene names	Cd248, Tem1
Domain Architecture	No domain graphic available
Description	Endosialin precursor (Tumor endothelial marker 1) (CD248 antigen).

CREL1_HUMAN
θ value	θ > 10 (rank : 78)	NC score	0.052835 (rank : 141)
Query Neighborhood Hits	68	Target Neighborhood Hits	441	Shared Neighborhood Hits	22
SwissProt Accessions	Q96HD1, Q6I9X5, Q8NFT4, Q9Y409	Gene names	CRELD1, CIRRIN
Domain Architecture	No domain graphic available
Description	Cysteine-rich with EGF-like domain protein 1 precursor.

CREL1_MOUSE
θ value	θ > 10 (rank : 79)	NC score	0.053218 (rank : 135)
Query Neighborhood Hits	68	Target Neighborhood Hits	524	Shared Neighborhood Hits	24
SwissProt Accessions	Q91XD7, Q8BGJ8	Gene names	Creld1
Domain Architecture	No domain graphic available
Description	Cysteine-rich with EGF-like domain protein 1 precursor.

CRUM1_HUMAN
θ value	θ > 10 (rank : 80)	NC score	0.050373 (rank : 162)
Query Neighborhood Hits	68	Target Neighborhood Hits	457	Shared Neighborhood Hits	35
SwissProt Accessions	P82279, Q5K3A6, Q5TC28, Q5VUT1, Q6N027, Q8WWY0	Gene names	CRB1
Domain Architecture
Description	Crumbs homolog 1 precursor.

CUBN_MOUSE
θ value	θ > 10 (rank : 81)	NC score	0.055788 (rank : 119)
Query Neighborhood Hits	68	Target Neighborhood Hits	477	Shared Neighborhood Hits	39
SwissProt Accessions	Q9JLB4	Gene names	Cubn, Ifcr
Domain Architecture	No domain graphic available
Description	Cubilin precursor (Intrinsic factor-cobalamin receptor).

DLL1_HUMAN
θ value	θ > 10 (rank : 82)	NC score	0.052916 (rank : 140)
Query Neighborhood Hits	68	Target Neighborhood Hits	455	Shared Neighborhood Hits	40
SwissProt Accessions	O00548, Q9NU41, Q9UJV2	Gene names	DLL1
Domain Architecture
Description	Delta-like protein 1 precursor (Drosophila Delta homolog 1) (Delta1) (H-Delta-1).

DLL1_MOUSE
θ value	θ > 10 (rank : 83)	NC score	0.053143 (rank : 138)
Query Neighborhood Hits	68	Target Neighborhood Hits	456	Shared Neighborhood Hits	37
SwissProt Accessions	Q61483	Gene names	Dll1
Domain Architecture
Description	Delta-like protein 1 precursor (Drosophila Delta homolog 1) (Delta1).

EGFL7_HUMAN
θ value	θ > 10 (rank : 84)	NC score	0.051005 (rank : 158)
Query Neighborhood Hits	68	Target Neighborhood Hits	325	Shared Neighborhood Hits	20
SwissProt Accessions	Q9UHF1, Q5M7Y5, Q5VUD5, Q96EG0	Gene names	EGFL7, MEGF7
Domain Architecture	No domain graphic available
Description	EGF-like domain-containing protein 7 precursor (Multiple EGF-like domain protein 7) (Multiple epidermal growth factor-like domain protein 7) (Vascular endothelial statin) (VE-statin) (NOTCH4-like protein) (ZNEU1).

EGF_HUMAN
θ value	θ > 10 (rank : 85)	NC score	0.140414 (rank : 48)
Query Neighborhood Hits	68	Target Neighborhood Hits	343	Shared Neighborhood Hits	24
SwissProt Accessions	P01133	Gene names	EGF
Domain Architecture
Description	Pro-epidermal growth factor precursor (EGF) [Contains: Epidermal growth factor (Urogastrone)].

EGF_MOUSE
θ value	θ > 10 (rank : 86)	NC score	0.136178 (rank : 49)
Query Neighborhood Hits	68	Target Neighborhood Hits	358	Shared Neighborhood Hits	26
SwissProt Accessions	P01132, Q6P9J2	Gene names	Egf
Domain Architecture
Description	Pro-epidermal growth factor precursor (EGF) [Contains: Epidermal growth factor].

ENTK_HUMAN
θ value	θ > 10 (rank : 87)	NC score	0.084135 (rank : 68)
Query Neighborhood Hits	68	Target Neighborhood Hits	310	Shared Neighborhood Hits	49
SwissProt Accessions	P98073	Gene names	PRSS7, ENTK
Domain Architecture
Description	Enteropeptidase precursor (EC 3.4.21.9) (Enterokinase) [Contains: Enteropeptidase non-catalytic heavy chain; Enteropeptidase catalytic light chain].

FA10_MOUSE
θ value	θ > 10 (rank : 88)	NC score	0.051310 (rank : 155)
Query Neighborhood Hits	68	Target Neighborhood Hits	435	Shared Neighborhood Hits	36
SwissProt Accessions	O88947, O54740, Q99L32	Gene names	F10
Domain Architecture
Description	Coagulation factor X precursor (EC 3.4.21.6) (Stuart factor) [Contains: Factor X light chain; Factor X heavy chain; Activated factor Xa heavy chain].

FA9_HUMAN
θ value	θ > 10 (rank : 89)	NC score	0.052286 (rank : 146)
Query Neighborhood Hits	68	Target Neighborhood Hits	421	Shared Neighborhood Hits	37
SwissProt Accessions	P00740	Gene names	F9
Domain Architecture
Description	Coagulation factor IX precursor (EC 3.4.21.22) (Christmas factor) (Plasma thromboplastin component) (PTC) [Contains: Coagulation factor IXa light chain; Coagulation factor IXa heavy chain].

FBLN1_HUMAN
θ value	θ > 10 (rank : 90)	NC score	0.061364 (rank : 93)
Query Neighborhood Hits	68	Target Neighborhood Hits	324	Shared Neighborhood Hits	29
SwissProt Accessions	P23142, P23143, P23144, P37888, Q5TIC4, Q8TBH8, Q9HBQ5, Q9UC21, Q9UGR4, Q9UH41	Gene names	FBLN1
Domain Architecture
Description	Fibulin-1 precursor.

FBLN1_MOUSE
θ value	θ > 10 (rank : 91)	NC score	0.064690 (rank : 81)
Query Neighborhood Hits	68	Target Neighborhood Hits	329	Shared Neighborhood Hits	29
SwissProt Accessions	Q08879, Q08878, Q8C3B1, Q91ZC9, Q922K8	Gene names	Fbln1
Domain Architecture
Description	Fibulin-1 precursor (Basement-membrane protein 90) (BM-90).

FBLN2_HUMAN
θ value	θ > 10 (rank : 92)	NC score	0.059840 (rank : 99)
Query Neighborhood Hits	68	Target Neighborhood Hits	392	Shared Neighborhood Hits	29
SwissProt Accessions	P98095	Gene names	FBLN2
Domain Architecture
Description	Fibulin-2 precursor.

FBLN2_MOUSE
θ value	θ > 10 (rank : 93)	NC score	0.062957 (rank : 89)
Query Neighborhood Hits	68	Target Neighborhood Hits	505	Shared Neighborhood Hits	33
SwissProt Accessions	P37889, Q9WUI2	Gene names	Fbln2
Domain Architecture
Description	Fibulin-2 precursor.

FBLN3_HUMAN
θ value	θ > 10 (rank : 94)	NC score	0.053880 (rank : 133)
Query Neighborhood Hits	68	Target Neighborhood Hits	293	Shared Neighborhood Hits	27
SwissProt Accessions	Q12805	Gene names	EFEMP1, FBLN3, FBNL
Domain Architecture
Description	EGF-containing fibulin-like extracellular matrix protein 1 precursor (Fibulin-3) (FIBL-3) (Fibrillin-like protein) (Extracellular protein S1-5).

FBLN3_MOUSE
θ value	θ > 10 (rank : 95)	NC score	0.051388 (rank : 154)
Query Neighborhood Hits	68	Target Neighborhood Hits	279	Shared Neighborhood Hits	25
SwissProt Accessions	Q8BPB5, Q6Y3N6	Gene names	Efemp1, Fbln3
Domain Architecture	No domain graphic available
Description	EGF-containing fibulin-like extracellular matrix protein 1 precursor (Fibulin-3) (FIBL-3).

FBLN4_HUMAN
θ value	θ > 10 (rank : 96)	NC score	0.054122 (rank : 131)
Query Neighborhood Hits	68	Target Neighborhood Hits	278	Shared Neighborhood Hits	24
SwissProt Accessions	O95967, O75967	Gene names	EFEMP2, FBLN4
Domain Architecture
Description	EGF-containing fibulin-like extracellular matrix protein 2 precursor (Fibulin-4) (FIBL-4) (UPH1 protein).

FBLN4_MOUSE
θ value	θ > 10 (rank : 97)	NC score	0.054198 (rank : 129)
Query Neighborhood Hits	68	Target Neighborhood Hits	270	Shared Neighborhood Hits	23
SwissProt Accessions	Q9WVJ9	Gene names	Efemp2, Fbln4, Mbp1
Domain Architecture
Description	EGF-containing fibulin-like extracellular matrix protein 2 precursor (Fibulin-4) (FIBL-4) (Mutant p53-binding protein 1).

FBLN5_HUMAN
θ value	θ > 10 (rank : 98)	NC score	0.057928 (rank : 108)
Query Neighborhood Hits	68	Target Neighborhood Hits	329	Shared Neighborhood Hits	29
SwissProt Accessions	Q9UBX5, O75966, Q6UWA3	Gene names	FBLN5, DANCE
Domain Architecture
Description	Fibulin-5 precursor (FIBL-5) (Developmental arteries and neural crest EGF-like protein) (Dance) (Urine p50 protein) (UP50).

FBLN5_MOUSE
θ value	θ > 10 (rank : 99)	NC score	0.057392 (rank : 113)
Query Neighborhood Hits	68	Target Neighborhood Hits	317	Shared Neighborhood Hits	26
SwissProt Accessions	Q9WVH9, Q541Z7	Gene names	Fbln5, Dance
Domain Architecture
Description	Fibulin-5 precursor (FIBL-5) (Developmental arteries and neural crest EGF-like protein) (Dance).

FBN1_HUMAN
θ value	θ > 10 (rank : 100)	NC score	0.059655 (rank : 101)
Query Neighborhood Hits	68	Target Neighborhood Hits	557	Shared Neighborhood Hits	33
SwissProt Accessions	P35555, Q15972, Q75N87	Gene names	FBN1, FBN
Domain Architecture
Description	Fibrillin-1 precursor.

FBN1_MOUSE
θ value	θ > 10 (rank : 101)	NC score	0.059800 (rank : 100)
Query Neighborhood Hits	68	Target Neighborhood Hits	563	Shared Neighborhood Hits	37
SwissProt Accessions	Q61554, Q60826	Gene names	Fbn1, Fbn-1
Domain Architecture
Description	Fibrillin-1 precursor.

FBN2_HUMAN
θ value	θ > 10 (rank : 102)	NC score	0.058474 (rank : 106)
Query Neighborhood Hits	68	Target Neighborhood Hits	560	Shared Neighborhood Hits	33
SwissProt Accessions	P35556	Gene names	FBN2
Domain Architecture
Description	Fibrillin-2 precursor.

FBN2_MOUSE
θ value	θ > 10 (rank : 103)	NC score	0.057924 (rank : 109)
Query Neighborhood Hits	68	Target Neighborhood Hits	549	Shared Neighborhood Hits	33
SwissProt Accessions	Q61555, Q63957	Gene names	Fbn2, Fbn-2
Domain Architecture
Description	Fibrillin-2 precursor.

FBN3_HUMAN
θ value	θ > 10 (rank : 104)	NC score	0.059205 (rank : 104)
Query Neighborhood Hits	68	Target Neighborhood Hits	543	Shared Neighborhood Hits	31
SwissProt Accessions	Q75N90, Q75N91, Q75N92, Q75N93, Q86SJ5, Q96JP8	Gene names	FBN3, KIAA1776
Domain Architecture	No domain graphic available
Description	Fibrillin-3 precursor.

GAS6_HUMAN
θ value	θ > 10 (rank : 105)	NC score	0.063975 (rank : 83)
Query Neighborhood Hits	68	Target Neighborhood Hits	348	Shared Neighborhood Hits	30
SwissProt Accessions	Q14393, Q7Z7N3	Gene names	GAS6
Domain Architecture
Description	Growth-arrest-specific protein 6 precursor (GAS-6).

GAS6_MOUSE
θ value	θ > 10 (rank : 106)	NC score	0.064924 (rank : 79)
Query Neighborhood Hits	68	Target Neighborhood Hits	343	Shared Neighborhood Hits	25
SwissProt Accessions	Q61592, Q99K57	Gene names	Gas6
Domain Architecture
Description	Growth-arrest-specific protein 6 precursor (GAS-6).

GLU2B_HUMAN
θ value	θ > 10 (rank : 107)	NC score	0.110362 (rank : 62)
Query Neighborhood Hits	68	Target Neighborhood Hits	377	Shared Neighborhood Hits	37
SwissProt Accessions	P14314, Q96BU9, Q96D06, Q9P0W9	Gene names	PRKCSH, G19P1
Domain Architecture	No domain graphic available
Description	Glucosidase 2 subunit beta precursor (Glucosidase II subunit beta) (Protein kinase C substrate, 60.1 kDa protein, heavy chain) (PKCSH) (80K-H protein).

GLU2B_MOUSE
θ value	θ > 10 (rank : 108)	NC score	0.104247 (rank : 65)
Query Neighborhood Hits	68	Target Neighborhood Hits	357	Shared Neighborhood Hits	38
SwissProt Accessions	O08795, Q921X2	Gene names	Prkcsh
Domain Architecture	No domain graphic available
Description	Glucosidase 2 subunit beta precursor (Glucosidase II subunit beta) (Protein kinase C substrate, 60.1 kDa protein, heavy chain) (PKCSH) (80K-H protein).

GRN_HUMAN
θ value	θ > 10 (rank : 109)	NC score	0.082583 (rank : 70)
Query Neighborhood Hits	68	Target Neighborhood Hits	268	Shared Neighborhood Hits	26
SwissProt Accessions	P28799, P23781, P23782, P23783, P23784, Q9BWE7, Q9UCH0	Gene names	GRN
Domain Architecture
Description	Granulins precursor (Proepithelin) (PEPI) [Contains: Acrogranin; Paragranulin; Granulin-1 (Granulin G); Granulin-2 (Granulin F); Granulin-3 (Granulin B); Granulin-4 (Granulin A); Granulin-5 (Granulin C); Granulin-6 (Granulin D); Granulin-7 (Granulin E)].

GRN_MOUSE
θ value	θ > 10 (rank : 110)	NC score	0.059449 (rank : 103)
Query Neighborhood Hits	68	Target Neighborhood Hits	248	Shared Neighborhood Hits	22
SwissProt Accessions	P28798	Gene names	Grn
Domain Architecture
Description	Granulins precursor (Proepithelin) (PEPI) (PC cell-derived growth factor) (PCDGF) [Contains: Acrogranin; Granulin-1; Granulin-2; Granulin-3; Granulin-4; Granulin-5; Granulin-6; Granulin-7].

IDD_HUMAN
θ value	θ > 10 (rank : 111)	NC score	0.162637 (rank : 43)
Query Neighborhood Hits	68	Target Neighborhood Hits	127	Shared Neighborhood Hits	45
SwissProt Accessions	P98153	Gene names	DGCR2, IDD, KIAA0163
Domain Architecture
Description	Integral membrane protein DGCR2/IDD precursor.

IDD_MOUSE
θ value	θ > 10 (rank : 112)	NC score	0.147889 (rank : 45)
Query Neighborhood Hits	68	Target Neighborhood Hits	151	Shared Neighborhood Hits	42
SwissProt Accessions	P98154, Q61844	Gene names	Dgcr2, Dgsc, Idd, Sez-12, Sez12
Domain Architecture
Description	Integral membrane protein DGCR2/IDD precursor (Seizure-related membrane-bound adhesion protein).

JAG1_HUMAN
θ value	θ > 10 (rank : 113)	NC score	0.050711 (rank : 160)
Query Neighborhood Hits	68	Target Neighborhood Hits	514	Shared Neighborhood Hits	34
SwissProt Accessions	P78504, O14902, O15122, Q15816	Gene names	JAG1, JAGL1
Domain Architecture
Description	Jagged-1 precursor (Jagged1) (hJ1) (CD339 antigen).

JAG1_MOUSE
θ value	θ > 10 (rank : 114)	NC score	0.051646 (rank : 151)
Query Neighborhood Hits	68	Target Neighborhood Hits	518	Shared Neighborhood Hits	34
SwissProt Accessions	Q9QXX0	Gene names	Jag1
Domain Architecture
Description	Jagged-1 precursor (Jagged1) (CD339 antigen).

JAG2_HUMAN
θ value	θ > 10 (rank : 115)	NC score	0.054500 (rank : 128)
Query Neighborhood Hits	68	Target Neighborhood Hits	491	Shared Neighborhood Hits	35
SwissProt Accessions	Q9Y219, Q9UE17, Q9UE99, Q9UNK8, Q9Y6P9, Q9Y6Q0	Gene names	JAG2
Domain Architecture
Description	Jagged-2 precursor (Jagged2) (HJ2).

JAG2_MOUSE
θ value	θ > 10 (rank : 116)	NC score	0.054720 (rank : 126)
Query Neighborhood Hits	68	Target Neighborhood Hits	504	Shared Neighborhood Hits	38
SwissProt Accessions	Q9QYE5, O55139, O70219	Gene names	Jag2
Domain Architecture
Description	Jagged-2 precursor (Jagged2).

KR107_HUMAN
θ value	θ > 10 (rank : 117)	NC score	0.050635 (rank : 161)
Query Neighborhood Hits	68	Target Neighborhood Hits	330	Shared Neighborhood Hits	25
SwissProt Accessions	P60409, Q70LJ2	Gene names	KRTAP10-7, KAP10.7, KAP18-7, KRTAP10.7, KRTAP18-7, KRTAP18.7
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 10-7 (Keratin-associated protein 10.7) (High sulfur keratin-associated protein 10.7) (Keratin-associated protein 18-7) (Keratin-associated protein 18.7).

LCE3B_HUMAN
θ value	θ > 10 (rank : 118)	NC score	0.053163 (rank : 136)
Query Neighborhood Hits	68	Target Neighborhood Hits	47	Shared Neighborhood Hits	9
SwissProt Accessions	Q5TA77	Gene names	LCE3B, LEP14
Domain Architecture	No domain graphic available
Description	Late cornified envelope protein 3B (Late envelope protein 14).

LRP11_HUMAN
θ value	θ > 10 (rank : 119)	NC score	0.151255 (rank : 44)
Query Neighborhood Hits	68	Target Neighborhood Hits	82	Shared Neighborhood Hits	46
SwissProt Accessions	Q86VZ4, Q5VYC0, Q96SN6	Gene names	LRP11
Domain Architecture
Description	Low-density lipoprotein receptor-related protein 11 precursor.

LTB1L_HUMAN
θ value	θ > 10 (rank : 120)	NC score	0.063125 (rank : 88)
Query Neighborhood Hits	68	Target Neighborhood Hits	553	Shared Neighborhood Hits	35
SwissProt Accessions	Q14766	Gene names	LTBP1
Domain Architecture
Description	Latent-transforming growth factor beta-binding protein, isoform 1L precursor (LTBP-1) (Transforming growth factor beta-1-binding protein 1) (TGF-beta1-BP-1).

LTB1L_MOUSE
θ value	θ > 10 (rank : 121)	NC score	0.058945 (rank : 105)
Query Neighborhood Hits	68	Target Neighborhood Hits	514	Shared Neighborhood Hits	36
SwissProt Accessions	Q8CG19, O88349, Q8BNW7, Q8C7F5, Q8CIR0	Gene names	Ltbp1
Domain Architecture
Description	Latent-transforming growth factor beta-binding protein, isoform 1L precursor (LTBP-1) (Transforming growth factor beta-1-binding protein 1) (TGF-beta1-BP-1).

LTB1S_HUMAN
θ value	θ > 10 (rank : 122)	NC score	0.061311 (rank : 94)
Query Neighborhood Hits	68	Target Neighborhood Hits	502	Shared Neighborhood Hits	32
SwissProt Accessions	P22064, Q8TD95	Gene names	LTBP1
Domain Architecture
Description	Latent-transforming growth factor beta-binding protein, isoform 1S precursor (LTBP-1) (Transforming growth factor beta-1-binding protein 1) (TGF-beta1-BP-1).

LTB1S_MOUSE
θ value	θ > 10 (rank : 123)	NC score	0.057857 (rank : 111)
Query Neighborhood Hits	68	Target Neighborhood Hits	479	Shared Neighborhood Hits	33
SwissProt Accessions	Q8CG18, Q8BNW7, Q8C7F5, Q8CIR0	Gene names	Ltbp1
Domain Architecture
Description	Latent-transforming growth factor beta-binding protein, isoform 1S precursor (LTBP-1) (Transforming growth factor beta-1-binding protein 1) (TGF-beta1-BP-1).

LTBP2_HUMAN
θ value	θ > 10 (rank : 124)	NC score	0.063624 (rank : 84)
Query Neighborhood Hits	68	Target Neighborhood Hits	552	Shared Neighborhood Hits	34
SwissProt Accessions	Q14767, Q99907, Q9NS51	Gene names	LTBP2
Domain Architecture
Description	Latent-transforming growth factor beta-binding protein 2 precursor (LTBP-2).

LTBP2_MOUSE
θ value	θ > 10 (rank : 125)	NC score	0.052091 (rank : 147)
Query Neighborhood Hits	68	Target Neighborhood Hits	617	Shared Neighborhood Hits	31
SwissProt Accessions	O08999, Q8C6W9	Gene names	Ltbp2
Domain Architecture
Description	Latent-transforming growth factor beta-binding protein 2 precursor (LTBP-2).

LTBP3_HUMAN
θ value	θ > 10 (rank : 126)	NC score	0.051967 (rank : 149)
Query Neighborhood Hits	68	Target Neighborhood Hits	502	Shared Neighborhood Hits	31
SwissProt Accessions	Q9NS15, O15107, Q96HB9, Q9H7K2, Q9UFN4	Gene names	LTBP3
Domain Architecture
Description	Latent-transforming growth factor beta-binding protein 3 precursor (LTBP-3).

LTBP3_MOUSE
θ value	θ > 10 (rank : 127)	NC score	0.052581 (rank : 143)
Query Neighborhood Hits	68	Target Neighborhood Hits	475	Shared Neighborhood Hits	33
SwissProt Accessions	Q61810, Q8BNQ6	Gene names	Ltbp3
Domain Architecture
Description	Latent-transforming growth factor beta-binding protein 3 precursor (LTBP-3).

LTBP4_MOUSE
θ value	θ > 10 (rank : 128)	NC score	0.053976 (rank : 132)
Query Neighborhood Hits	68	Target Neighborhood Hits	607	Shared Neighborhood Hits	34
SwissProt Accessions	Q8K4G1, Q8K4G0	Gene names	Ltbp4
Domain Architecture
Description	Latent-transforming growth factor beta-binding protein 4 precursor (LTBP-4).

MASP1_HUMAN
θ value	θ > 10 (rank : 129)	NC score	0.054133 (rank : 130)
Query Neighborhood Hits	68	Target Neighborhood Hits	369	Shared Neighborhood Hits	33
SwissProt Accessions	P48740, O95570, Q9UF09	Gene names	MASP1, CRARF, CRARF1, PRSS5
Domain Architecture
Description	Complement-activating component of Ra-reactive factor precursor (EC 3.4.21.-) (Ra-reactive factor serine protease p100) (RaRF) (Mannan-binding lectin serine protease 1) (Mannose-binding protein- associated serine protease) (MASP-1) [Contains: Complement-activating component of Ra-reactive factor heavy chain; Complement-activating component of Ra-reactive factor light chain].

MASP1_MOUSE
θ value	θ > 10 (rank : 130)	NC score	0.052316 (rank : 145)
Query Neighborhood Hits	68	Target Neighborhood Hits	364	Shared Neighborhood Hits	32
SwissProt Accessions	P98064	Gene names	Masp1, Crarf
Domain Architecture
Description	Complement-activating component of Ra-reactive factor precursor (EC 3.4.21.-) (Ra-reactive factor serine protease p100) (RaRF) (Mannan-binding lectin serine protease 1) [Contains: Complement- activating component of Ra-reactive factor heavy chain; Complement- activating component of Ra-reactive factor light chain].

MASP2_HUMAN
θ value	θ > 10 (rank : 131)	NC score	0.053303 (rank : 134)
Query Neighborhood Hits	68	Target Neighborhood Hits	364	Shared Neighborhood Hits	33
SwissProt Accessions	O00187, O75754, Q5TEQ5, Q5TER0, Q96QG4, Q9BZH0, Q9H498, Q9H499, Q9UBP3, Q9ULC7, Q9UMV3, Q9Y270	Gene names	MASP2
Domain Architecture
Description	Mannan-binding lectin serine protease 2 precursor (EC 3.4.21.104) (Mannose-binding protein-associated serine protease 2) (MASP-2) (MBL- associated serine protease 2) [Contains: Mannan-binding lectin serine protease 2 A chain; Mannan-binding lectin serine protease 2 B chain].

MASP2_MOUSE
θ value	θ > 10 (rank : 132)	NC score	0.051097 (rank : 157)
Query Neighborhood Hits	68	Target Neighborhood Hits	382	Shared Neighborhood Hits	32
SwissProt Accessions	Q91WP0, Q9QXA4, Q9QXD2, Q9QXD5, Q9Z338	Gene names	Masp2
Domain Architecture	No domain graphic available
Description	Mannan-binding lectin serine protease 2 precursor (EC 3.4.21.104) (Mannose-binding protein-associated serine protease 2) (MASP-2) (MBL- associated serine protease 2) [Contains: Mannan-binding lectin serine protease 2 A chain; Mannan-binding lectin serine protease 2 B chain].

MATN2_HUMAN
θ value	θ > 10 (rank : 133)	NC score	0.056512 (rank : 116)
Query Neighborhood Hits	68	Target Neighborhood Hits	365	Shared Neighborhood Hits	27
SwissProt Accessions	O00339, Q6UWA5, Q7Z5X1, Q8NDE6, Q96FT5, Q9NSZ1	Gene names	MATN2
Domain Architecture
Description	Matrilin-2 precursor.

MATN2_MOUSE
θ value	θ > 10 (rank : 134)	NC score	0.050739 (rank : 159)
Query Neighborhood Hits	68	Target Neighborhood Hits	356	Shared Neighborhood Hits	25
SwissProt Accessions	O08746	Gene names	Matn2
Domain Architecture
Description	Matrilin-2 precursor.

MATN4_HUMAN
θ value	θ > 10 (rank : 135)	NC score	0.053147 (rank : 137)
Query Neighborhood Hits	68	Target Neighborhood Hits	287	Shared Neighborhood Hits	24
SwissProt Accessions	O95460, Q5QPU2, Q5QPU3, Q5QPU4, Q8N2M5, Q8N2M7, Q9H1F8, Q9H1F9	Gene names	MATN4
Domain Architecture
Description	Matrilin-4 precursor.

MATN4_MOUSE
θ value	θ > 10 (rank : 136)	NC score	0.052815 (rank : 142)
Query Neighborhood Hits	68	Target Neighborhood Hits	277	Shared Neighborhood Hits	26
SwissProt Accessions	O89029, O89030, Q9QWS3	Gene names	Matn4
Domain Architecture
Description	Matrilin-4 precursor (MAT-4).

MEGF6_HUMAN
θ value	θ > 10 (rank : 137)	NC score	0.055650 (rank : 122)
Query Neighborhood Hits	68	Target Neighborhood Hits	671	Shared Neighborhood Hits	36
SwissProt Accessions	O75095, Q5VV39	Gene names	MEGF6, EGFL3, KIAA0815
Domain Architecture	No domain graphic available
Description	Multiple epidermal growth factor-like domains 6 precursor (EGF-like domain-containing protein 3) (Multiple EGF-like domain protein 3).

MFRP_HUMAN
θ value	θ > 10 (rank : 138)	NC score	0.127706 (rank : 51)
Query Neighborhood Hits	68	Target Neighborhood Hits	165	Shared Neighborhood Hits	46
SwissProt Accessions	Q9BY79, Q335M3, Q96DQ9	Gene names	MFRP
Domain Architecture	No domain graphic available
Description	Membrane frizzled-related protein (Membrane-type frizzled-related protein).

MFRP_MOUSE
θ value	θ > 10 (rank : 139)	NC score	0.116974 (rank : 58)
Query Neighborhood Hits	68	Target Neighborhood Hits	166	Shared Neighborhood Hits	48
SwissProt Accessions	Q8K480, Q8BPP4	Gene names	Mfrp
Domain Architecture	No domain graphic available
Description	Membrane frizzled-related protein (Membrane-type frizzled-related protein).

NELL1_HUMAN
θ value	θ > 10 (rank : 140)	NC score	0.050089 (rank : 163)
Query Neighborhood Hits	68	Target Neighborhood Hits	451	Shared Neighborhood Hits	26
SwissProt Accessions	Q92832, Q9Y472	Gene names	NELL1, NRP1
Domain Architecture
Description	Protein kinase C-binding protein NELL1 precursor (NEL-like protein 1) (Nel-related protein 1).

NELL2_HUMAN
θ value	θ > 10 (rank : 141)	NC score	0.052032 (rank : 148)
Query Neighborhood Hits	68	Target Neighborhood Hits	449	Shared Neighborhood Hits	30
SwissProt Accessions	Q99435	Gene names	NELL2, NRP2
Domain Architecture
Description	Protein kinase C-binding protein NELL2 precursor (NEL-like protein 2) (Nel-related protein 2).

NELL2_MOUSE
θ value	θ > 10 (rank : 142)	NC score	0.051148 (rank : 156)
Query Neighborhood Hits	68	Target Neighborhood Hits	436	Shared Neighborhood Hits	27
SwissProt Accessions	Q61220	Gene names	Nell2, Mel91
Domain Architecture
Description	Protein kinase C-binding protein NELL2 precursor (NEL-like protein 2) (MEL91 protein).

NETO1_HUMAN
θ value	θ > 10 (rank : 143)	NC score	0.067940 (rank : 75)
Query Neighborhood Hits	68	Target Neighborhood Hits	110	Shared Neighborhood Hits	43
SwissProt Accessions	Q8TDF5, Q86W85, Q8ND78, Q8TDF4	Gene names	NETO1, BTCL1
Domain Architecture	No domain graphic available
Description	Neuropilin and tolloid-like protein 1 precursor (Brain-specific transmembrane protein containing 2 CUB and 1 LDL-receptor class A domains protein 1).

NETO1_MOUSE
θ value	θ > 10 (rank : 144)	NC score	0.067649 (rank : 76)
Query Neighborhood Hits	68	Target Neighborhood Hits	109	Shared Neighborhood Hits	43
SwissProt Accessions	Q8R4I7, Q80X39, Q8C4S3, Q8CCM2	Gene names	Neto1, Btcl1
Domain Architecture	No domain graphic available
Description	Neuropilin and tolloid-like protein 1 precursor (Brain-specific transmembrane protein containing 2 CUB and 1 LDL-receptor class A domains protein 1).

NETO2_HUMAN
θ value	θ > 10 (rank : 145)	NC score	0.064712 (rank : 80)
Query Neighborhood Hits	68	Target Neighborhood Hits	109	Shared Neighborhood Hits	39
SwissProt Accessions	Q8NC67, Q7Z381, Q8ND51, Q96SP4, Q9NVY8	Gene names	NETO2, BTCL2
Domain Architecture	No domain graphic available
Description	Neuropilin and tolloid-like protein 2 precursor (Brain-specific transmembrane protein containing 2 CUB and 1 LDL-receptor class A domains protein 2).

NETO2_MOUSE
θ value	θ > 10 (rank : 146)	NC score	0.064484 (rank : 82)
Query Neighborhood Hits	68	Target Neighborhood Hits	113	Shared Neighborhood Hits	39
SwissProt Accessions	Q8BNJ6, Q5VM49, Q8C4Q8	Gene names	Neto2, Btcl2
Domain Architecture	No domain graphic available
Description	Neuropilin and tolloid-like protein 2 precursor (Brain-specific transmembrane protein containing 2 CUB and 1 LDL-receptor class A domains protein 2).

NID1_HUMAN
θ value	θ > 10 (rank : 147)	NC score	0.113492 (rank : 61)
Query Neighborhood Hits	68	Target Neighborhood Hits	329	Shared Neighborhood Hits	24
SwissProt Accessions	P14543, Q14942, Q59FL2, Q5TAF2, Q5TAF3, Q86XD7	Gene names	NID1, NID
Domain Architecture
Description	Nidogen-1 precursor (Entactin).

NID1_MOUSE
θ value	θ > 10 (rank : 148)	NC score	0.114722 (rank : 59)
Query Neighborhood Hits	68	Target Neighborhood Hits	335	Shared Neighborhood Hits	25
SwissProt Accessions	P10493, Q8BQI3, Q8C3U8, Q8C9P6	Gene names	Nid1, Ent
Domain Architecture
Description	Nidogen-1 precursor (Entactin).

NID2_HUMAN
θ value	θ > 10 (rank : 149)	NC score	0.105986 (rank : 64)
Query Neighborhood Hits	68	Target Neighborhood Hits	456	Shared Neighborhood Hits	24
SwissProt Accessions	Q14112, O43710	Gene names	NID2
Domain Architecture
Description	Nidogen-2 precursor (NID-2) (Osteonidogen).

NID2_MOUSE
θ value	θ > 10 (rank : 150)	NC score	0.107593 (rank : 63)
Query Neighborhood Hits	68	Target Neighborhood Hits	338	Shared Neighborhood Hits	26
SwissProt Accessions	O88322	Gene names	Nid2
Domain Architecture
Description	Nidogen-2 precursor (NID-2) (Entactin-2).

NOTC1_MOUSE
θ value	θ > 10 (rank : 151)	NC score	0.051458 (rank : 153)
Query Neighborhood Hits	68	Target Neighborhood Hits	916	Shared Neighborhood Hits	40
SwissProt Accessions	Q01705, Q06007, Q61905, Q99JC2, Q9QW58, Q9R0X7	Gene names	Notch1, Motch
Domain Architecture
Description	Neurogenic locus notch homolog protein 1 precursor (Notch 1) (Motch A) (mT14) (p300) [Contains: Notch 1 extracellular truncation; Notch 1 intracellular domain].

PERF_MOUSE
θ value	θ > 10 (rank : 152)	NC score	0.055599 (rank : 123)
Query Neighborhood Hits	68	Target Neighborhood Hits	45	Shared Neighborhood Hits	8
SwissProt Accessions	P10820	Gene names	Prf1, Pfp
Domain Architecture
Description	Perforin-1 precursor (P1) (Lymphocyte pore-forming protein) (Cytolysin).

PROC_MOUSE
θ value	θ > 10 (rank : 153)	NC score	0.053024 (rank : 139)
Query Neighborhood Hits	68	Target Neighborhood Hits	426	Shared Neighborhood Hits	33
SwissProt Accessions	P33587, O35498, Q91WN8, Q99PC6	Gene names	Proc
Domain Architecture
Description	Vitamin K-dependent protein C precursor (EC 3.4.21.69) (Autoprothrombin IIA) (Anticoagulant protein C) (Blood coagulation factor XIV) [Contains: Vitamin K-dependent protein C light chain; Vitamin K-dependent protein C heavy chain; Activation peptide].

PROS_HUMAN
θ value	θ > 10 (rank : 154)	NC score	0.061963 (rank : 92)
Query Neighborhood Hits	68	Target Neighborhood Hits	340	Shared Neighborhood Hits	29
SwissProt Accessions	P07225, Q15518, Q7Z715	Gene names	PROS1, PROS
Domain Architecture
Description	Vitamin K-dependent protein S precursor.

PROS_MOUSE
θ value	θ > 10 (rank : 155)	NC score	0.059993 (rank : 98)
Query Neighborhood Hits	68	Target Neighborhood Hits	330	Shared Neighborhood Hits	25
SwissProt Accessions	Q08761, P43483	Gene names	Pros1, Pros
Domain Architecture
Description	Vitamin K-dependent protein S precursor.

PROZ_HUMAN
θ value	θ > 10 (rank : 156)	NC score	0.061986 (rank : 91)
Query Neighborhood Hits	68	Target Neighborhood Hits	422	Shared Neighborhood Hits	34
SwissProt Accessions	P22891, Q15213	Gene names	PROZ
Domain Architecture
Description	Vitamin K-dependent protein Z precursor.

PROZ_MOUSE
θ value	θ > 10 (rank : 157)	NC score	0.055853 (rank : 118)
Query Neighborhood Hits	68	Target Neighborhood Hits	410	Shared Neighborhood Hits	30
SwissProt Accessions	Q9CQW3	Gene names	Proz
Domain Architecture
Description	Vitamin K-dependent protein Z precursor.

RXFP2_HUMAN
θ value	θ > 10 (rank : 158)	NC score	0.055524 (rank : 124)
Query Neighborhood Hits	68	Target Neighborhood Hits	736	Shared Neighborhood Hits	48
SwissProt Accessions	Q8WXD0	Gene names	RXFP2, GPR106, GREAT, LGR8
Domain Architecture
Description	Relaxin receptor 2 (Relaxin family peptide receptor 2) (Leucine-rich repeat-containing G-protein coupled receptor 8) (G-protein coupled receptor affecting testicular descent) (G-protein coupled receptor 106).

SCUB3_HUMAN
θ value	θ > 10 (rank : 159)	NC score	0.074447 (rank : 71)
Query Neighborhood Hits	68	Target Neighborhood Hits	428	Shared Neighborhood Hits	33
SwissProt Accessions	Q8IX30, Q5CZB3, Q86UZ9, Q8NAU9	Gene names	SCUBE3, CEGF3
Domain Architecture	No domain graphic available
Description	Signal peptide, CUB and EGF-like domain-containing protein 3 precursor.

SCUB3_MOUSE
θ value	θ > 10 (rank : 160)	NC score	0.074125 (rank : 72)
Query Neighborhood Hits	68	Target Neighborhood Hits	442	Shared Neighborhood Hits	33
SwissProt Accessions	Q66PY1, Q68FG9	Gene names	Scube3
Domain Architecture	No domain graphic available
Description	Signal peptide, CUB and EGF-like domain-containing protein 3 precursor.

SPIT1_HUMAN
θ value	θ > 10 (rank : 161)	NC score	0.146332 (rank : 46)
Query Neighborhood Hits	68	Target Neighborhood Hits	100	Shared Neighborhood Hits	45
SwissProt Accessions	O43278, Q7Z7D2	Gene names	SPINT1, HAI1
Domain Architecture
Description	Kunitz-type protease inhibitor 1 precursor (Hepatocyte growth factor activator inhibitor type 1) (HAI-1).

TENA_HUMAN
θ value	θ > 10 (rank : 162)	NC score	0.063506 (rank : 85)
Query Neighborhood Hits	68	Target Neighborhood Hits	631	Shared Neighborhood Hits	38
SwissProt Accessions	P24821, Q14583, Q15567	Gene names	TNC, HXB
Domain Architecture
Description	Tenascin precursor (TN) (Tenascin-C) (TN-C) (Hexabrachion) (Cytotactin) (Neuronectin) (GMEM) (JI) (Myotendinous antigen) (Glioma- associated-extracellular matrix antigen) (GP 150-225).

TENA_MOUSE
θ value	θ > 10 (rank : 163)	NC score	0.063476 (rank : 86)
Query Neighborhood Hits	68	Target Neighborhood Hits	596	Shared Neighborhood Hits	42
SwissProt Accessions	Q80YX1, Q64706, Q80YX2	Gene names	Tnc, Hxb
Domain Architecture	No domain graphic available
Description	Tenascin precursor (TN) (Tenascin-C) (TN-C) (Hexabrachion).

TLL1_HUMAN
θ value	θ > 10 (rank : 164)	NC score	0.057882 (rank : 110)
Query Neighborhood Hits	68	Target Neighborhood Hits	236	Shared Neighborhood Hits	27
SwissProt Accessions	O43897, Q96AN3, Q9NQS4	Gene names	TLL1, TLL
Domain Architecture	No domain graphic available
Description	Tolloid-like protein 1 precursor (EC 3.4.24.-).

TLL1_MOUSE
θ value	θ > 10 (rank : 165)	NC score	0.058048 (rank : 107)
Query Neighborhood Hits	68	Target Neighborhood Hits	237	Shared Neighborhood Hits	27
SwissProt Accessions	Q62381, Q3UTT9, Q8BNP5	Gene names	Tll1, Tll
Domain Architecture	No domain graphic available
Description	Tolloid-like protein 1 precursor (EC 3.4.24.-) (mTll).

TLL2_HUMAN
θ value	θ > 10 (rank : 166)	NC score	0.054709 (rank : 127)
Query Neighborhood Hits	68	Target Neighborhood Hits	241	Shared Neighborhood Hits	28
SwissProt Accessions	Q9Y6L7, Q6PJN5, Q9UQ00	Gene names	TLL2, KIAA0932
Domain Architecture	No domain graphic available
Description	Tolloid-like protein 2 precursor (EC 3.4.24.-).

TLL2_MOUSE
θ value	θ > 10 (rank : 167)	NC score	0.055782 (rank : 120)
Query Neighborhood Hits	68	Target Neighborhood Hits	240	Shared Neighborhood Hits	28
SwissProt Accessions	Q9WVM6	Gene names	Tll2
Domain Architecture	No domain graphic available
Description	Tolloid-like protein 2 precursor (EC 3.4.24.-).

TMPS2_HUMAN
θ value	θ > 10 (rank : 168)	NC score	0.056634 (rank : 115)
Query Neighborhood Hits	68	Target Neighborhood Hits	252	Shared Neighborhood Hits	40
SwissProt Accessions	O15393, Q9BXX1	Gene names	TMPRSS2, PRSS10
Domain Architecture
Description	Transmembrane protease, serine 2 precursor (EC 3.4.21.-) [Contains: Transmembrane protease, serine 2 non-catalytic chain; Transmembrane protease, serine 2 catalytic chain].

TMPS2_MOUSE
θ value	θ > 10 (rank : 169)	NC score	0.063399 (rank : 87)
Query Neighborhood Hits	68	Target Neighborhood Hits	243	Shared Neighborhood Hits	48
SwissProt Accessions	Q9JIQ8, Q9JKC4, Q9QY82	Gene names	Tmprss2
Domain Architecture
Description	Transmembrane protease, serine 2 (EC 3.4.21.-) (Epitheliasin) (Plasmic transmembrane protein X) [Contains: Transmembrane protease, serine 2 non-catalytic chain; Transmembrane protease, serine 2 catalytic chain].

TMPS3_HUMAN
θ value	θ > 10 (rank : 170)	NC score	0.059637 (rank : 102)
Query Neighborhood Hits	68	Target Neighborhood Hits	245	Shared Neighborhood Hits	48
SwissProt Accessions	P57727, Q6ZMC3	Gene names	TMPRSS3, ECHOS1, TADG12
Domain Architecture
Description	Transmembrane protease, serine 3 (EC 3.4.21.-) (Serine protease TADG- 12) (Tumor-associated differentially-expressed gene 12 protein).

TMPS3_MOUSE
θ value	θ > 10 (rank : 171)	NC score	0.054814 (rank : 125)
Query Neighborhood Hits	68	Target Neighborhood Hits	239	Shared Neighborhood Hits	43
SwissProt Accessions	Q8K1T0, Q8VDE0	Gene names	Tmprss3
Domain Architecture
Description	Transmembrane protease, serine 3 (EC 3.4.21.-).

TMPS7_HUMAN
θ value	θ > 10 (rank : 172)	NC score	0.125001 (rank : 52)
Query Neighborhood Hits	68	Target Neighborhood Hits	275	Shared Neighborhood Hits	49
SwissProt Accessions	Q7RTY8	Gene names	TMPRSS7
Domain Architecture	No domain graphic available
Description	Transmembrane protease, serine 7 precursor (EC 3.4.21.-).

TRBM_HUMAN
θ value	θ > 10 (rank : 173)	NC score	0.060963 (rank : 96)
Query Neighborhood Hits	68	Target Neighborhood Hits	339	Shared Neighborhood Hits	26
SwissProt Accessions	P07204, Q9UC32	Gene names	THBD, THRM
Domain Architecture
Description	Thrombomodulin precursor (TM) (Fetomodulin) (CD141 antigen).

TRBM_MOUSE
θ value	θ > 10 (rank : 174)	NC score	0.062590 (rank : 90)
Query Neighborhood Hits	68	Target Neighborhood Hits	361	Shared Neighborhood Hits	27
SwissProt Accessions	P15306	Gene names	Thbd
Domain Architecture
Description	Thrombomodulin precursor (TM) (Fetomodulin) (CD141 antigen).

ZAN_MOUSE
θ value	θ > 10 (rank : 175)	NC score	0.069270 (rank : 74)
Query Neighborhood Hits	68	Target Neighborhood Hits	808	Shared Neighborhood Hits	36
SwissProt Accessions	O88799, O08647	Gene names	Zan
Domain Architecture
Description	Zonadhesin precursor.

Hits sorted by NC score

CR001_HUMAN
NC score	0.999962 (rank : 1)	θ value	6.35588e-163 (rank : 1)
Query Neighborhood Hits	68	Target Neighborhood Hits	68	Shared Neighborhood Hits	68
SwissProt Accessions	O15165, O15166, O15167, O15168, Q6NXP3	Gene names	C18orf1
Domain Architecture
Description	Protein C18orf1.

CR001_MOUSE
NC score	0.994703 (rank : 2)	θ value	4.26331e-159 (rank : 2)
Query Neighborhood Hits	68	Target Neighborhood Hits	67	Shared Neighborhood Hits	59
SwissProt Accessions	Q8BWJ4	Gene names	D18Ertd653e
Domain Architecture	No domain graphic available
Description	Protein C18orf1 homolog.

TMEPA_MOUSE
NC score	0.890232 (rank : 3)	θ value	1.95861e-79 (rank : 4)
Query Neighborhood Hits	68	Target Neighborhood Hits	46	Shared Neighborhood Hits	10
SwissProt Accessions	Q9D7R2, Q9EQH9	Gene names	Tmepai, N4wbp4
Domain Architecture	No domain graphic available
Description	Transmembrane prostate androgen-induced protein (NEDD4 WW domain- binding protein 4).

TMEPA_HUMAN
NC score	0.886250 (rank : 4)	θ value	3.56943e-81 (rank : 3)
Query Neighborhood Hits	68	Target Neighborhood Hits	46	Shared Neighborhood Hits	11
SwissProt Accessions	Q969W9, Q5TDR6, Q96B72, Q9UJD3	Gene names	TMEPAI, PMEPA1, STAG1
Domain Architecture
Description	Transmembrane prostate androgen-induced protein (Solid tumor- associated 1 protein).

CD320_HUMAN
NC score	0.348844 (rank : 5)	θ value	0.21417 (rank : 36)
Query Neighborhood Hits	68	Target Neighborhood Hits	103	Shared Neighborhood Hits	51
SwissProt Accessions	Q9NPF0, Q53HF7	Gene names	CD320, 8D6A
Domain Architecture	No domain graphic available
Description	CD320 antigen precursor (8D6 antigen) (FDC-signaling molecule 8D6) (FDC-SM-8D6).

LRP10_HUMAN
NC score	0.319069 (rank : 6)	θ value	0.0252991 (rank : 31)
Query Neighborhood Hits	68	Target Neighborhood Hits	197	Shared Neighborhood Hits	52
SwissProt Accessions	Q7Z4F1, O95882, Q86T02, Q8NCZ4, Q9HC42, Q9UG33	Gene names	LRP10
Domain Architecture
Description	Low-density lipoprotein receptor-related protein 10 precursor.

CO9_HUMAN
NC score	0.314248 (rank : 7)	θ value	0.00390308 (rank : 20)
Query Neighborhood Hits	68	Target Neighborhood Hits	147	Shared Neighborhood Hits	52
SwissProt Accessions	P02748	Gene names	C9
Domain Architecture
Description	Complement component C9 precursor [Contains: Complement component C9a; Complement component C9b].

LRP3_HUMAN
NC score	0.312450 (rank : 8)	θ value	0.00134147 (rank : 15)
Query Neighborhood Hits	68	Target Neighborhood Hits	280	Shared Neighborhood Hits	52
SwissProt Accessions	O75074	Gene names	LRP3
Domain Architecture
Description	Low-density lipoprotein receptor-related protein 3 precursor (hLRp105).

LRP10_MOUSE
NC score	0.310001 (rank : 9)	θ value	0.125558 (rank : 35)
Query Neighborhood Hits	68	Target Neighborhood Hits	169	Shared Neighborhood Hits	51
SwissProt Accessions	Q7TQH7, Q7TS95, Q921T0, Q9EPE8	Gene names	Lrp10, Lrp9
Domain Architecture
Description	Low-density lipoprotein receptor-related protein 10 precursor.

LRP6_MOUSE
NC score	0.304713 (rank : 10)	θ value	0.00869519 (rank : 25)
Query Neighborhood Hits	68	Target Neighborhood Hits	232	Shared Neighborhood Hits	52
SwissProt Accessions	O88572	Gene names	Lrp6
Domain Architecture
Description	Low-density lipoprotein receptor-related protein 6 precursor.

LRP6_HUMAN
NC score	0.304261 (rank : 11)	θ value	0.00869519 (rank : 24)
Query Neighborhood Hits	68	Target Neighborhood Hits	235	Shared Neighborhood Hits	52
SwissProt Accessions	O75581	Gene names	LRP6
Domain Architecture
Description	Low-density lipoprotein receptor-related protein 6 precursor.

CO9_MOUSE
NC score	0.295447 (rank : 12)	θ value	0.0113563 (rank : 26)
Query Neighborhood Hits	68	Target Neighborhood Hits	153	Shared Neighborhood Hits	51
SwissProt Accessions	P06683, Q91XA7	Gene names	C9
Domain Architecture
Description	Complement component C9 precursor.

LRP5_MOUSE
NC score	0.294081 (rank : 13)	θ value	0.47712 (rank : 38)
Query Neighborhood Hits	68	Target Neighborhood Hits	236	Shared Neighborhood Hits	51
SwissProt Accessions	Q91VN0, O88883, Q9R208	Gene names	Lrp5, Lrp7
Domain Architecture
Description	Low-density lipoprotein receptor-related protein 5 precursor (LRP7) (Lr3).

LRP5_HUMAN
NC score	0.290574 (rank : 14)	θ value	1.81305 (rank : 49)
Query Neighborhood Hits	68	Target Neighborhood Hits	224	Shared Neighborhood Hits	51
SwissProt Accessions	O75197, Q96TD6, Q9UP66	Gene names	LRP5, LRP7
Domain Architecture
Description	Low-density lipoprotein receptor-related protein 5 precursor.

LRP4_HUMAN
NC score	0.289933 (rank : 15)	θ value	0.000786445 (rank : 10)
Query Neighborhood Hits	68	Target Neighborhood Hits	355	Shared Neighborhood Hits	53
SwissProt Accessions	O75096	Gene names	LRP4, KIAA0816, MEGF7
Domain Architecture
Description	Low-density lipoprotein receptor-related protein 4 precursor (Multiple epidermal growth factor-like domains 7).

LRP4_MOUSE
NC score	0.289603 (rank : 16)	θ value	0.000602161 (rank : 8)
Query Neighborhood Hits	68	Target Neighborhood Hits	351	Shared Neighborhood Hits	53
SwissProt Accessions	Q8VI56, Q8BPX5, Q8CBB3, Q8CCP5	Gene names	Lrp4, Kiaa0816
Domain Architecture
Description	Low-density lipoprotein receptor-related protein 4 precursor (LDLR dan).

LRP12_MOUSE
NC score	0.289407 (rank : 17)	θ value	0.00102713 (rank : 13)
Query Neighborhood Hits	68	Target Neighborhood Hits	180	Shared Neighborhood Hits	51
SwissProt Accessions	Q8BUJ9, Q8BWM9	Gene names	Lrp12
Domain Architecture
Description	Low-density lipoprotein receptor-related protein 12 precursor.

LRP12_HUMAN
NC score	0.289346 (rank : 18)	θ value	0.00102713 (rank : 12)
Query Neighborhood Hits	68	Target Neighborhood Hits	205	Shared Neighborhood Hits	52
SwissProt Accessions	Q9Y561	Gene names	LRP12, ST7
Domain Architecture
Description	Low-density lipoprotein receptor-related protein 12 precursor (Suppressor of tumorigenicity protein 7).

VLDLR_HUMAN
NC score	0.288996 (rank : 19)	θ value	0.00228821 (rank : 19)
Query Neighborhood Hits	68	Target Neighborhood Hits	383	Shared Neighborhood Hits	54
SwissProt Accessions	P98155, Q5VVF6	Gene names	VLDLR
Domain Architecture
Description	Very low-density lipoprotein receptor precursor (VLDL receptor) (VLDL- R).

LDLR_MOUSE
NC score	0.287315 (rank : 20)	θ value	0.00509761 (rank : 23)
Query Neighborhood Hits	68	Target Neighborhood Hits	382	Shared Neighborhood Hits	53
SwissProt Accessions	P35951	Gene names	Ldlr
Domain Architecture
Description	Low-density lipoprotein receptor precursor (LDL receptor).

VLDLR_MOUSE
NC score	0.286376 (rank : 21)	θ value	0.00390308 (rank : 22)
Query Neighborhood Hits	68	Target Neighborhood Hits	360	Shared Neighborhood Hits	54
SwissProt Accessions	P98156, Q64022	Gene names	Vldlr
Domain Architecture
Description	Very low-density lipoprotein receptor precursor (VLDL receptor) (VLDL- R).

LRP2_HUMAN
NC score	0.284353 (rank : 22)	θ value	0.00020696 (rank : 7)
Query Neighborhood Hits	68	Target Neighborhood Hits	573	Shared Neighborhood Hits	54
SwissProt Accessions	P98164, O00711, Q16215	Gene names	LRP2
Domain Architecture
Description	Low-density lipoprotein receptor-related protein 2 precursor (Megalin) (Glycoprotein 330) (gp330).

LRP8_MOUSE
NC score	0.282565 (rank : 23)	θ value	0.00228821 (rank : 18)
Query Neighborhood Hits	68	Target Neighborhood Hits	385	Shared Neighborhood Hits	52
SwissProt Accessions	Q924X6, Q8CAK9, Q8CDF5, Q921B6	Gene names	Lrp8, Apoer2
Domain Architecture
Description	Low-density lipoprotein receptor-related protein 8 precursor (Apolipoprotein E receptor 2).

LRP8_HUMAN
NC score	0.282025 (rank : 24)	θ value	0.0193708 (rank : 29)
Query Neighborhood Hits	68	Target Neighborhood Hits	346	Shared Neighborhood Hits	53
SwissProt Accessions	Q14114, O14968, Q86V27, Q99876, Q9BR78	Gene names	LRP8, APOER2
Domain Architecture
Description	Low-density lipoprotein receptor-related protein 8 precursor (Apolipoprotein E receptor 2).

LDLR_HUMAN
NC score	0.279598 (rank : 25)	θ value	0.0113563 (rank : 27)
Query Neighborhood Hits	68	Target Neighborhood Hits	375	Shared Neighborhood Hits	53
SwissProt Accessions	P01130, Q53ZD9	Gene names	LDLR
Domain Architecture
Description	Low-density lipoprotein receptor precursor (LDL receptor).

SORL_MOUSE
NC score	0.271863 (rank : 26)	θ value	0.0193708 (rank : 30)
Query Neighborhood Hits	68	Target Neighborhood Hits	439	Shared Neighborhood Hits	53
SwissProt Accessions	O88307, O54711, O70581	Gene names	Sorl1
Domain Architecture
Description	Sortilin-related receptor precursor (Sorting protein-related receptor containing LDLR class A repeats) (mSorLA) (SorLA-1) (Low-density lipoprotein receptor relative with 11 ligand-binding repeats) (LDLR relative with 11 ligand-binding repeats) (LR11) (Gp250).

SORL_HUMAN
NC score	0.270490 (rank : 27)	θ value	0.0431538 (rank : 34)
Query Neighborhood Hits	68	Target Neighborhood Hits	440	Shared Neighborhood Hits	52
SwissProt Accessions	Q92673, Q92856	Gene names	SORL1
Domain Architecture
Description	Sortilin-related receptor precursor (Sorting protein-related receptor containing LDLR class A repeats) (SorLA) (SorLA-1) (Low-density lipoprotein receptor relative with 11 ligand-binding repeats) (LDLR relative with 11 ligand-binding repeats) (LR11).

LRP1B_MOUSE
NC score	0.262981 (rank : 28)	θ value	0.00175202 (rank : 17)
Query Neighborhood Hits	68	Target Neighborhood Hits	606	Shared Neighborhood Hits	55
SwissProt Accessions	Q9JI18, Q8BZD3, Q8BZM7	Gene names	Lrp1b, Lrpdit
Domain Architecture
Description	Low-density lipoprotein receptor-related protein 1B precursor (Low- density lipoprotein receptor-related protein-deleted in tumor) (LRP- DIT).

LRP1_HUMAN
NC score	0.262814 (rank : 29)	θ value	0.000786445 (rank : 9)
Query Neighborhood Hits	68	Target Neighborhood Hits	617	Shared Neighborhood Hits	55
SwissProt Accessions	Q07954, Q2PP12, Q8IVG8	Gene names	LRP1, A2MR
Domain Architecture
Description	Low-density lipoprotein receptor-related protein 1 precursor (LRP) (Alpha-2-macroglobulin receptor) (A2MR) (Apolipoprotein E receptor) (APOER) (CD91 antigen).

LRP1B_HUMAN
NC score	0.262403 (rank : 30)	θ value	0.00175202 (rank : 16)
Query Neighborhood Hits	68	Target Neighborhood Hits	602	Shared Neighborhood Hits	54
SwissProt Accessions	Q9NZR2, Q8WY29, Q8WY30, Q8WY31	Gene names	LRP1B, LRPDIT
Domain Architecture
Description	Low-density lipoprotein receptor-related protein 1B precursor (Low- density lipoprotein receptor-related protein-deleted in tumor) (LRP- DIT).

CO6_HUMAN
NC score	0.245451 (rank : 31)	θ value	0.000121331 (rank : 6)
Query Neighborhood Hits	68	Target Neighborhood Hits	331	Shared Neighborhood Hits	55
SwissProt Accessions	P13671	Gene names	C6
Domain Architecture
Description	Complement component C6 precursor.

CO8B_HUMAN
NC score	0.234655 (rank : 32)	θ value	0.0431538 (rank : 32)
Query Neighborhood Hits	68	Target Neighborhood Hits	199	Shared Neighborhood Hits	51
SwissProt Accessions	P07358	Gene names	C8B
Domain Architecture
Description	Complement component C8 beta chain precursor (Complement component 8 subunit beta).

CO8B_MOUSE
NC score	0.227941 (rank : 33)	θ value	0.0431538 (rank : 33)
Query Neighborhood Hits	68	Target Neighborhood Hits	224	Shared Neighborhood Hits	52
SwissProt Accessions	Q8BH35, Q4VAH1, Q8CHJ5, Q8CHJ6, Q8VC14	Gene names	C8b
Domain Architecture	No domain graphic available
Description	Complement component C8 beta chain precursor (Complement component 8 subunit beta).

CO8A_MOUSE
NC score	0.226259 (rank : 34)	θ value	0.62314 (rank : 41)
Query Neighborhood Hits	68	Target Neighborhood Hits	182	Shared Neighborhood Hits	52
SwissProt Accessions	Q8K182, Q8CHJ9, Q8CHK1	Gene names	C8a
Domain Architecture	No domain graphic available
Description	Complement component C8 alpha chain precursor (Complement component 8 subunit alpha).

SSPO_MOUSE
NC score	0.219731 (rank : 35)	θ value	9.29e-05 (rank : 5)
Query Neighborhood Hits	68	Target Neighborhood Hits	800	Shared Neighborhood Hits	56
SwissProt Accessions	Q8CG65	Gene names	Sspo
Domain Architecture	No domain graphic available
Description	SCO-spondin precursor.

CO8A_HUMAN
NC score	0.217326 (rank : 36)	θ value	1.06291 (rank : 46)
Query Neighborhood Hits	68	Target Neighborhood Hits	200	Shared Neighborhood Hits	52
SwissProt Accessions	P07357, Q13668, Q9H130	Gene names	C8A
Domain Architecture
Description	Complement component C8 alpha chain precursor (Complement component 8 subunit alpha).

CO7_HUMAN
NC score	0.196091 (rank : 37)	θ value	0.21417 (rank : 37)
Query Neighborhood Hits	68	Target Neighborhood Hits	278	Shared Neighborhood Hits	52
SwissProt Accessions	P10643, Q6P3T5, Q92489	Gene names	C7
Domain Architecture
Description	Complement component C7 precursor.

CORIN_HUMAN
NC score	0.174376 (rank : 38)	θ value	0.00134147 (rank : 14)
Query Neighborhood Hits	68	Target Neighborhood Hits	453	Shared Neighborhood Hits	51
SwissProt Accessions	Q9Y5Q5, Q9UHY2	Gene names	CORIN, CRN, TMPRSS10
Domain Architecture
Description	Atrial natriuteric peptide-converting enzyme (EC 3.4.21.-) (pro-ANP- converting enzyme) (Corin) (Heart-specific serine proteinase ATC2) (Transmembrane protease, serine 10).

CORIN_MOUSE
NC score	0.174344 (rank : 39)	θ value	0.00102713 (rank : 11)
Query Neighborhood Hits	68	Target Neighborhood Hits	451	Shared Neighborhood Hits	51
SwissProt Accessions	Q9Z319	Gene names	Corin, Crn, Lrp4
Domain Architecture
Description	Atrial natriuteric peptide-converting enzyme (EC 3.4.21.-) (pro-ANP- converting enzyme) (Corin) (Low density lipoprotein receptor-related protein 4).

LRP11_MOUSE
NC score	0.168885 (rank : 40)	θ value	6.88961 (rank : 66)
Query Neighborhood Hits	68	Target Neighborhood Hits	81	Shared Neighborhood Hits	50
SwissProt Accessions	Q8CB67, Q8C7Y7	Gene names	Lrp11
Domain Architecture
Description	Low-density lipoprotein receptor-related protein 11 precursor.

ST14_MOUSE
NC score	0.168330 (rank : 41)	θ value	0.00390308 (rank : 21)
Query Neighborhood Hits	68	Target Neighborhood Hits	419	Shared Neighborhood Hits	51
SwissProt Accessions	P56677	Gene names	St14, Prss14
Domain Architecture
Description	Suppressor of tumorigenicity protein 14 (EC 3.4.21.-) (Serine protease 14) (Epithin).

ST14_HUMAN
NC score	0.167090 (rank : 42)	θ value	0.0113563 (rank : 28)
Query Neighborhood Hits	68	Target Neighborhood Hits	409	Shared Neighborhood Hits	51
SwissProt Accessions	Q9Y5Y6, Q9BS01, Q9H3S0, Q9HB36, Q9HCA3	Gene names	ST14, PRSS14, SNC19, TADG15
Domain Architecture
Description	Suppressor of tumorigenicity protein 14 (EC 3.4.21.-) (Serine protease 14) (Matriptase) (Membrane-type serine protease 1) (MT-SP1) (Prostamin) (Serine protease TADG-15) (Tumor-associated differentially-expressed gene 15 protein).

IDD_HUMAN
NC score	0.162637 (rank : 43)	θ value	θ > 10 (rank : 111)
Query Neighborhood Hits	68	Target Neighborhood Hits	127	Shared Neighborhood Hits	45
SwissProt Accessions	P98153	Gene names	DGCR2, IDD, KIAA0163
Domain Architecture
Description	Integral membrane protein DGCR2/IDD precursor.

LRP11_HUMAN
NC score	0.151255 (rank : 44)	θ value	θ > 10 (rank : 119)
Query Neighborhood Hits	68	Target Neighborhood Hits	82	Shared Neighborhood Hits	46
SwissProt Accessions	Q86VZ4, Q5VYC0, Q96SN6	Gene names	LRP11
Domain Architecture
Description	Low-density lipoprotein receptor-related protein 11 precursor.

IDD_MOUSE
NC score	0.147889 (rank : 45)	θ value	θ > 10 (rank : 112)
Query Neighborhood Hits	68	Target Neighborhood Hits	151	Shared Neighborhood Hits	42
SwissProt Accessions	P98154, Q61844	Gene names	Dgcr2, Dgsc, Idd, Sez-12, Sez12
Domain Architecture
Description	Integral membrane protein DGCR2/IDD precursor (Seizure-related membrane-bound adhesion protein).

SPIT1_HUMAN
NC score	0.146332 (rank : 46)	θ value	θ > 10 (rank : 161)
Query Neighborhood Hits	68	Target Neighborhood Hits	100	Shared Neighborhood Hits	45
SwissProt Accessions	O43278, Q7Z7D2	Gene names	SPINT1, HAI1
Domain Architecture
Description	Kunitz-type protease inhibitor 1 precursor (Hepatocyte growth factor activator inhibitor type 1) (HAI-1).

SPIT1_MOUSE
NC score	0.145940 (rank : 47)	θ value	4.03905 (rank : 58)
Query Neighborhood Hits	68	Target Neighborhood Hits	96	Shared Neighborhood Hits	50
SwissProt Accessions	Q9R097	Gene names	Spint1, Hai1
Domain Architecture
Description	Kunitz-type protease inhibitor 1 precursor (Hepatocyte growth factor activator inhibitor type 1) (HAI-1).

EGF_HUMAN
NC score	0.140414 (rank : 48)	θ value	θ > 10 (rank : 85)
Query Neighborhood Hits	68	Target Neighborhood Hits	343	Shared Neighborhood Hits	24
SwissProt Accessions	P01133	Gene names	EGF
Domain Architecture
Description	Pro-epidermal growth factor precursor (EGF) [Contains: Epidermal growth factor (Urogastrone)].

EGF_MOUSE
NC score	0.136178 (rank : 49)	θ value	θ > 10 (rank : 86)
Query Neighborhood Hits	68	Target Neighborhood Hits	358	Shared Neighborhood Hits	26
SwissProt Accessions	P01132, Q6P9J2	Gene names	Egf
Domain Architecture
Description	Pro-epidermal growth factor precursor (EGF) [Contains: Epidermal growth factor].

TMPS7_MOUSE
NC score	0.131370 (rank : 50)	θ value	1.81305 (rank : 52)
Query Neighborhood Hits	68	Target Neighborhood Hits	275	Shared Neighborhood Hits	51
SwissProt Accessions	Q8BIK6	Gene names	Tmprss7
Domain Architecture	No domain graphic available
Description	Transmembrane protease, serine 7 precursor (EC 3.4.21.-).

MFRP_HUMAN
NC score	0.127706 (rank : 51)	θ value	θ > 10 (rank : 138)
Query Neighborhood Hits	68	Target Neighborhood Hits	165	Shared Neighborhood Hits	46
SwissProt Accessions	Q9BY79, Q335M3, Q96DQ9	Gene names	MFRP
Domain Architecture	No domain graphic available
Description	Membrane frizzled-related protein (Membrane-type frizzled-related protein).

TMPS7_HUMAN
NC score	0.125001 (rank : 52)	θ value	θ > 10 (rank : 172)
Query Neighborhood Hits	68	Target Neighborhood Hits	275	Shared Neighborhood Hits	49
SwissProt Accessions	Q7RTY8	Gene names	TMPRSS7
Domain Architecture	No domain graphic available
Description	Transmembrane protease, serine 7 precursor (EC 3.4.21.-).

CFAI_HUMAN
NC score	0.122698 (rank : 53)	θ value	4.03905 (rank : 56)
Query Neighborhood Hits	68	Target Neighborhood Hits	289	Shared Neighborhood Hits	51
SwissProt Accessions	P05156, O60442	Gene names	CFI, IF
Domain Architecture
Description	Complement factor I precursor (EC 3.4.21.45) (C3B/C4B inactivator) [Contains: Complement factor I heavy chain; Complement factor I light chain].

TMPS6_HUMAN
NC score	0.121621 (rank : 54)	θ value	4.03905 (rank : 59)
Query Neighborhood Hits	68	Target Neighborhood Hits	338	Shared Neighborhood Hits	51
SwissProt Accessions	Q8IU80, Q5TI06, Q6UXD8, Q8IUE2, Q8IXV8	Gene names	TMPRSS6
Domain Architecture
Description	Transmembrane protease, serine 6 (EC 3.4.21.-) (Matriptase-2).

PGBM_MOUSE
NC score	0.119887 (rank : 55)	θ value	1.81305 (rank : 50)
Query Neighborhood Hits	68	Target Neighborhood Hits	1073	Shared Neighborhood Hits	53
SwissProt Accessions	Q05793	Gene names	Hspg2
Domain Architecture
Description	Basement membrane-specific heparan sulfate proteoglycan core protein precursor (HSPG) (Perlecan) (PLC).

CFAI_MOUSE
NC score	0.118964 (rank : 56)	θ value	1.38821 (rank : 48)
Query Neighborhood Hits	68	Target Neighborhood Hits	290	Shared Neighborhood Hits	51
SwissProt Accessions	Q61129, Q9WU07	Gene names	Cfi, If
Domain Architecture
Description	Complement factor I precursor (EC 3.4.21.45) (C3B/C4B inactivator) [Contains: Complement factor I heavy chain; Complement factor I light chain].

TMPS6_MOUSE
NC score	0.118582 (rank : 57)	θ value	1.81305 (rank : 51)
Query Neighborhood Hits	68	Target Neighborhood Hits	341	Shared Neighborhood Hits	51
SwissProt Accessions	Q9DBI0, Q6PF94	Gene names	Tmprss6
Domain Architecture
Description	Transmembrane protease, serine 6 (EC 3.4.21.-) (Matriptase-2).

MFRP_MOUSE
NC score	0.116974 (rank : 58)	θ value	θ > 10 (rank : 139)
Query Neighborhood Hits	68	Target Neighborhood Hits	166	Shared Neighborhood Hits	48
SwissProt Accessions	Q8K480, Q8BPP4	Gene names	Mfrp
Domain Architecture	No domain graphic available
Description	Membrane frizzled-related protein (Membrane-type frizzled-related protein).

NID1_MOUSE
NC score	0.114722 (rank : 59)	θ value	θ > 10 (rank : 148)
Query Neighborhood Hits	68	Target Neighborhood Hits	335	Shared Neighborhood Hits	25
SwissProt Accessions	P10493, Q8BQI3, Q8C3U8, Q8C9P6	Gene names	Nid1, Ent
Domain Architecture
Description	Nidogen-1 precursor (Entactin).

PGBM_HUMAN
NC score	0.114647 (rank : 60)	θ value	1.06291 (rank : 47)
Query Neighborhood Hits	68	Target Neighborhood Hits	1113	Shared Neighborhood Hits	55
SwissProt Accessions	P98160, Q16287, Q9H3V5	Gene names	HSPG2
Domain Architecture
Description	Basement membrane-specific heparan sulfate proteoglycan core protein precursor (HSPG) (Perlecan) (PLC).

NID1_HUMAN
NC score	0.113492 (rank : 61)	θ value	θ > 10 (rank : 147)
Query Neighborhood Hits	68	Target Neighborhood Hits	329	Shared Neighborhood Hits	24
SwissProt Accessions	P14543, Q14942, Q59FL2, Q5TAF2, Q5TAF3, Q86XD7	Gene names	NID1, NID
Domain Architecture
Description	Nidogen-1 precursor (Entactin).

GLU2B_HUMAN
NC score	0.110362 (rank : 62)	θ value	θ > 10 (rank : 107)
Query Neighborhood Hits	68	Target Neighborhood Hits	377	Shared Neighborhood Hits	37
SwissProt Accessions	P14314, Q96BU9, Q96D06, Q9P0W9	Gene names	PRKCSH, G19P1
Domain Architecture	No domain graphic available
Description	Glucosidase 2 subunit beta precursor (Glucosidase II subunit beta) (Protein kinase C substrate, 60.1 kDa protein, heavy chain) (PKCSH) (80K-H protein).

NID2_MOUSE
NC score	0.107593 (rank : 63)	θ value	θ > 10 (rank : 150)
Query Neighborhood Hits	68	Target Neighborhood Hits	338	Shared Neighborhood Hits	26
SwissProt Accessions	O88322	Gene names	Nid2
Domain Architecture
Description	Nidogen-2 precursor (NID-2) (Entactin-2).

NID2_HUMAN
NC score	0.105986 (rank : 64)	θ value	θ > 10 (rank : 149)
Query Neighborhood Hits	68	Target Neighborhood Hits	456	Shared Neighborhood Hits	24
SwissProt Accessions	Q14112, O43710	Gene names	NID2
Domain Architecture
Description	Nidogen-2 precursor (NID-2) (Osteonidogen).

GLU2B_MOUSE
NC score	0.104247 (rank : 65)	θ value	θ > 10 (rank : 108)
Query Neighborhood Hits	68	Target Neighborhood Hits	357	Shared Neighborhood Hits	38
SwissProt Accessions	O08795, Q921X2	Gene names	Prkcsh
Domain Architecture	No domain graphic available
Description	Glucosidase 2 subunit beta precursor (Glucosidase II subunit beta) (Protein kinase C substrate, 60.1 kDa protein, heavy chain) (PKCSH) (80K-H protein).

ENTK_MOUSE
NC score	0.093224 (rank : 66)	θ value	0.62314 (rank : 42)
Query Neighborhood Hits	68	Target Neighborhood Hits	338	Shared Neighborhood Hits	50
SwissProt Accessions	P97435	Gene names	Prss7, Entk
Domain Architecture
Description	Enteropeptidase (EC 3.4.21.9) (Enterokinase) [Contains: Enteropeptidase non-catalytic heavy chain; Enteropeptidase catalytic light chain].

TMPS9_HUMAN
NC score	0.085393 (rank : 67)	θ value	0.62314 (rank : 44)
Query Neighborhood Hits	68	Target Neighborhood Hits	276	Shared Neighborhood Hits	49
SwissProt Accessions	Q7Z410, Q6ZND6, Q7Z411	Gene names	TMPRSS9
Domain Architecture	No domain graphic available
Description	Transmembrane protease, serine 9 (EC 3.4.21.-) (Polyserase-1) (Polyserase-I) (Polyserine protease 1) [Contains: Serase-1; Serase-2; Serase-3].

ENTK_HUMAN
NC score	0.084135 (rank : 68)	θ value	θ > 10 (rank : 87)
Query Neighborhood Hits	68	Target Neighborhood Hits	310	Shared Neighborhood Hits	49
SwissProt Accessions	P98073	Gene names	PRSS7, ENTK
Domain Architecture
Description	Enteropeptidase precursor (EC 3.4.21.9) (Enterokinase) [Contains: Enteropeptidase non-catalytic heavy chain; Enteropeptidase catalytic light chain].

TMPS9_MOUSE
NC score	0.083327 (rank : 69)	θ value	0.62314 (rank : 45)
Query Neighborhood Hits	68	Target Neighborhood Hits	296	Shared Neighborhood Hits	51
SwissProt Accessions	P69525	Gene names	Tmprss9
Domain Architecture	No domain graphic available
Description	Transmembrane protease, serine 9 (EC 3.4.21.-) (Polyserase-1) (Polyserine protease 1) (Polyserase-I) [Contains: Serase-1; Serase-2; Serase-3].

GRN_HUMAN
NC score	0.082583 (rank : 70)	θ value	θ > 10 (rank : 109)
Query Neighborhood Hits	68	Target Neighborhood Hits	268	Shared Neighborhood Hits	26
SwissProt Accessions	P28799, P23781, P23782, P23783, P23784, Q9BWE7, Q9UCH0	Gene names	GRN
Domain Architecture
Description	Granulins precursor (Proepithelin) (PEPI) [Contains: Acrogranin; Paragranulin; Granulin-1 (Granulin G); Granulin-2 (Granulin F); Granulin-3 (Granulin B); Granulin-4 (Granulin A); Granulin-5 (Granulin C); Granulin-6 (Granulin D); Granulin-7 (Granulin E)].

SCUB3_HUMAN
NC score	0.074447 (rank : 71)	θ value	θ > 10 (rank : 159)
Query Neighborhood Hits	68	Target Neighborhood Hits	428	Shared Neighborhood Hits	33
SwissProt Accessions	Q8IX30, Q5CZB3, Q86UZ9, Q8NAU9	Gene names	SCUBE3, CEGF3
Domain Architecture	No domain graphic available
Description	Signal peptide, CUB and EGF-like domain-containing protein 3 precursor.

SCUB3_MOUSE
NC score	0.074125 (rank : 72)	θ value	θ > 10 (rank : 160)
Query Neighborhood Hits	68	Target Neighborhood Hits	442	Shared Neighborhood Hits	33
SwissProt Accessions	Q66PY1, Q68FG9	Gene names	Scube3
Domain Architecture	No domain graphic available
Description	Signal peptide, CUB and EGF-like domain-containing protein 3 precursor.

GAB1_MOUSE
NC score	0.070299 (rank : 73)	θ value	0.62314 (rank : 43)
Query Neighborhood Hits	68	Target Neighborhood Hits	233	Shared Neighborhood Hits	10
SwissProt Accessions	Q9QYY0, Q91VW7	Gene names	Gab1
Domain Architecture
Description	GRB2-associated-binding protein 1 (GRB2-associated binder 1).

ZAN_MOUSE
NC score	0.069270 (rank : 74)	θ value	θ > 10 (rank : 175)
Query Neighborhood Hits	68	Target Neighborhood Hits	808	Shared Neighborhood Hits	36
SwissProt Accessions	O88799, O08647	Gene names	Zan
Domain Architecture
Description	Zonadhesin precursor.

NETO1_HUMAN
NC score	0.067940 (rank : 75)	θ value	θ > 10 (rank : 143)
Query Neighborhood Hits	68	Target Neighborhood Hits	110	Shared Neighborhood Hits	43
SwissProt Accessions	Q8TDF5, Q86W85, Q8ND78, Q8TDF4	Gene names	NETO1, BTCL1
Domain Architecture	No domain graphic available
Description	Neuropilin and tolloid-like protein 1 precursor (Brain-specific transmembrane protein containing 2 CUB and 1 LDL-receptor class A domains protein 1).

NETO1_MOUSE
NC score	0.067649 (rank : 76)	θ value	θ > 10 (rank : 144)
Query Neighborhood Hits	68	Target Neighborhood Hits	109	Shared Neighborhood Hits	43
SwissProt Accessions	Q8R4I7, Q80X39, Q8C4S3, Q8CCM2	Gene names	Neto1, Btcl1
Domain Architecture	No domain graphic available
Description	Neuropilin and tolloid-like protein 1 precursor (Brain-specific transmembrane protein containing 2 CUB and 1 LDL-receptor class A domains protein 1).

CD248_MOUSE
NC score	0.067599 (rank : 77)	θ value	θ > 10 (rank : 77)
Query Neighborhood Hits	68	Target Neighborhood Hits	578	Shared Neighborhood Hits	23
SwissProt Accessions	Q91V98, Q3UMV6, Q91ZV1	Gene names	Cd248, Tem1
Domain Architecture	No domain graphic available
Description	Endosialin precursor (Tumor endothelial marker 1) (CD248 antigen).

CD248_HUMAN
NC score	0.066665 (rank : 78)	θ value	θ > 10 (rank : 76)
Query Neighborhood Hits	68	Target Neighborhood Hits	679	Shared Neighborhood Hits	24
SwissProt Accessions	Q9HCU0, Q3SX55, Q96KB6	Gene names	CD248, CD164L1, TEM1
Domain Architecture	No domain graphic available
Description	Endosialin precursor (Tumor endothelial marker 1) (CD248 antigen).

GAS6_MOUSE
NC score	0.064924 (rank : 79)	θ value	θ > 10 (rank : 106)
Query Neighborhood Hits	68	Target Neighborhood Hits	343	Shared Neighborhood Hits	25
SwissProt Accessions	Q61592, Q99K57	Gene names	Gas6
Domain Architecture
Description	Growth-arrest-specific protein 6 precursor (GAS-6).

NETO2_HUMAN
NC score	0.064712 (rank : 80)	θ value	θ > 10 (rank : 145)
Query Neighborhood Hits	68	Target Neighborhood Hits	109	Shared Neighborhood Hits	39
SwissProt Accessions	Q8NC67, Q7Z381, Q8ND51, Q96SP4, Q9NVY8	Gene names	NETO2, BTCL2
Domain Architecture	No domain graphic available
Description	Neuropilin and tolloid-like protein 2 precursor (Brain-specific transmembrane protein containing 2 CUB and 1 LDL-receptor class A domains protein 2).

FBLN1_MOUSE
NC score	0.064690 (rank : 81)	θ value	θ > 10 (rank : 91)
Query Neighborhood Hits	68	Target Neighborhood Hits	329	Shared Neighborhood Hits	29
SwissProt Accessions	Q08879, Q08878, Q8C3B1, Q91ZC9, Q922K8	Gene names	Fbln1
Domain Architecture
Description	Fibulin-1 precursor (Basement-membrane protein 90) (BM-90).

NETO2_MOUSE
NC score	0.064484 (rank : 82)	θ value	θ > 10 (rank : 146)
Query Neighborhood Hits	68	Target Neighborhood Hits	113	Shared Neighborhood Hits	39
SwissProt Accessions	Q8BNJ6, Q5VM49, Q8C4Q8	Gene names	Neto2, Btcl2
Domain Architecture	No domain graphic available
Description	Neuropilin and tolloid-like protein 2 precursor (Brain-specific transmembrane protein containing 2 CUB and 1 LDL-receptor class A domains protein 2).

GAS6_HUMAN
NC score	0.063975 (rank : 83)	θ value	θ > 10 (rank : 105)
Query Neighborhood Hits	68	Target Neighborhood Hits	348	Shared Neighborhood Hits	30
SwissProt Accessions	Q14393, Q7Z7N3	Gene names	GAS6
Domain Architecture
Description	Growth-arrest-specific protein 6 precursor (GAS-6).

LTBP2_HUMAN
NC score	0.063624 (rank : 84)	θ value	θ > 10 (rank : 124)
Query Neighborhood Hits	68	Target Neighborhood Hits	552	Shared Neighborhood Hits	34
SwissProt Accessions	Q14767, Q99907, Q9NS51	Gene names	LTBP2
Domain Architecture
Description	Latent-transforming growth factor beta-binding protein 2 precursor (LTBP-2).

TENA_HUMAN
NC score	0.063506 (rank : 85)	θ value	θ > 10 (rank : 162)
Query Neighborhood Hits	68	Target Neighborhood Hits	631	Shared Neighborhood Hits	38
SwissProt Accessions	P24821, Q14583, Q15567	Gene names	TNC, HXB
Domain Architecture
Description	Tenascin precursor (TN) (Tenascin-C) (TN-C) (Hexabrachion) (Cytotactin) (Neuronectin) (GMEM) (JI) (Myotendinous antigen) (Glioma- associated-extracellular matrix antigen) (GP 150-225).

TENA_MOUSE
NC score	0.063476 (rank : 86)	θ value	θ > 10 (rank : 163)
Query Neighborhood Hits	68	Target Neighborhood Hits	596	Shared Neighborhood Hits	42
SwissProt Accessions	Q80YX1, Q64706, Q80YX2	Gene names	Tnc, Hxb
Domain Architecture	No domain graphic available
Description	Tenascin precursor (TN) (Tenascin-C) (TN-C) (Hexabrachion).

TMPS2_MOUSE
NC score	0.063399 (rank : 87)	θ value	θ > 10 (rank : 169)
Query Neighborhood Hits	68	Target Neighborhood Hits	243	Shared Neighborhood Hits	48
SwissProt Accessions	Q9JIQ8, Q9JKC4, Q9QY82	Gene names	Tmprss2
Domain Architecture
Description	Transmembrane protease, serine 2 (EC 3.4.21.-) (Epitheliasin) (Plasmic transmembrane protein X) [Contains: Transmembrane protease, serine 2 non-catalytic chain; Transmembrane protease, serine 2 catalytic chain].

LTB1L_HUMAN
NC score	0.063125 (rank : 88)	θ value	θ > 10 (rank : 120)
Query Neighborhood Hits	68	Target Neighborhood Hits	553	Shared Neighborhood Hits	35
SwissProt Accessions	Q14766	Gene names	LTBP1
Domain Architecture
Description	Latent-transforming growth factor beta-binding protein, isoform 1L precursor (LTBP-1) (Transforming growth factor beta-1-binding protein 1) (TGF-beta1-BP-1).

FBLN2_MOUSE
NC score	0.062957 (rank : 89)	θ value	θ > 10 (rank : 93)
Query Neighborhood Hits	68	Target Neighborhood Hits	505	Shared Neighborhood Hits	33
SwissProt Accessions	P37889, Q9WUI2	Gene names	Fbln2
Domain Architecture
Description	Fibulin-2 precursor.

TRBM_MOUSE
NC score	0.062590 (rank : 90)	θ value	θ > 10 (rank : 174)
Query Neighborhood Hits	68	Target Neighborhood Hits	361	Shared Neighborhood Hits	27
SwissProt Accessions	P15306	Gene names	Thbd
Domain Architecture
Description	Thrombomodulin precursor (TM) (Fetomodulin) (CD141 antigen).

PROZ_HUMAN
NC score	0.061986 (rank : 91)	θ value	θ > 10 (rank : 156)
Query Neighborhood Hits	68	Target Neighborhood Hits	422	Shared Neighborhood Hits	34
SwissProt Accessions	P22891, Q15213	Gene names	PROZ
Domain Architecture
Description	Vitamin K-dependent protein Z precursor.

PROS_HUMAN
NC score	0.061963 (rank : 92)	θ value	θ > 10 (rank : 154)
Query Neighborhood Hits	68	Target Neighborhood Hits	340	Shared Neighborhood Hits	29
SwissProt Accessions	P07225, Q15518, Q7Z715	Gene names	PROS1, PROS
Domain Architecture
Description	Vitamin K-dependent protein S precursor.

FBLN1_HUMAN
NC score	0.061364 (rank : 93)	θ value	θ > 10 (rank : 90)
Query Neighborhood Hits	68	Target Neighborhood Hits	324	Shared Neighborhood Hits	29
SwissProt Accessions	P23142, P23143, P23144, P37888, Q5TIC4, Q8TBH8, Q9HBQ5, Q9UC21, Q9UGR4, Q9UH41	Gene names	FBLN1
Domain Architecture
Description	Fibulin-1 precursor.

LTB1S_HUMAN
NC score	0.061311 (rank : 94)	θ value	θ > 10 (rank : 122)
Query Neighborhood Hits	68	Target Neighborhood Hits	502	Shared Neighborhood Hits	32
SwissProt Accessions	P22064, Q8TD95	Gene names	LTBP1
Domain Architecture
Description	Latent-transforming growth factor beta-binding protein, isoform 1S precursor (LTBP-1) (Transforming growth factor beta-1-binding protein 1) (TGF-beta1-BP-1).

GNAS3_MOUSE
NC score	0.061009 (rank : 95)	θ value	5.27518 (rank : 61)
Query Neighborhood Hits	68	Target Neighborhood Hits	84	Shared Neighborhood Hits	7
SwissProt Accessions	Q9Z0F1, Q9QXW5, Q9Z0H2	Gene names	Gnas, Gnas1
Domain Architecture	No domain graphic available
Description	Neuroendocrine secretory protein 55 (NESP55) [Contains: LHAL tetrapeptide; GPIPIRRH peptide].

TRBM_HUMAN
NC score	0.060963 (rank : 96)	θ value	θ > 10 (rank : 173)
Query Neighborhood Hits	68	Target Neighborhood Hits	339	Shared Neighborhood Hits	26
SwissProt Accessions	P07204, Q9UC32	Gene names	THBD, THRM
Domain Architecture
Description	Thrombomodulin precursor (TM) (Fetomodulin) (CD141 antigen).

C1QR1_HUMAN
NC score	0.060293 (rank : 97)	θ value	θ > 10 (rank : 71)
Query Neighborhood Hits	68	Target Neighborhood Hits	493	Shared Neighborhood Hits	28
SwissProt Accessions	Q9NPY3, O00274	Gene names	CD93, C1QR1, MXRA4
Domain Architecture
Description	Complement component C1q receptor precursor (Complement component 1 q subcomponent receptor 1) (C1qR) (C1qRp) (C1qR(p)) (C1q/MBL/SPA receptor) (CD93 antigen) (CDw93).

PROS_MOUSE
NC score	0.059993 (rank : 98)	θ value	θ > 10 (rank : 155)
Query Neighborhood Hits	68	Target Neighborhood Hits	330	Shared Neighborhood Hits	25
SwissProt Accessions	Q08761, P43483	Gene names	Pros1, Pros
Domain Architecture
Description	Vitamin K-dependent protein S precursor.

FBLN2_HUMAN
NC score	0.059840 (rank : 99)	θ value	θ > 10 (rank : 92)
Query Neighborhood Hits	68	Target Neighborhood Hits	392	Shared Neighborhood Hits	29
SwissProt Accessions	P98095	Gene names	FBLN2
Domain Architecture
Description	Fibulin-2 precursor.

FBN1_MOUSE
NC score	0.059800 (rank : 100)	θ value	θ > 10 (rank : 101)
Query Neighborhood Hits	68	Target Neighborhood Hits	563	Shared Neighborhood Hits	37
SwissProt Accessions	Q61554, Q60826	Gene names	Fbn1, Fbn-1
Domain Architecture
Description	Fibrillin-1 precursor.

FBN1_HUMAN
NC score	0.059655 (rank : 101)	θ value	θ > 10 (rank : 100)
Query Neighborhood Hits	68	Target Neighborhood Hits	557	Shared Neighborhood Hits	33
SwissProt Accessions	P35555, Q15972, Q75N87	Gene names	FBN1, FBN
Domain Architecture
Description	Fibrillin-1 precursor.

TMPS3_HUMAN
NC score	0.059637 (rank : 102)	θ value	θ > 10 (rank : 170)
Query Neighborhood Hits	68	Target Neighborhood Hits	245	Shared Neighborhood Hits	48
SwissProt Accessions	P57727, Q6ZMC3	Gene names	TMPRSS3, ECHOS1, TADG12
Domain Architecture
Description	Transmembrane protease, serine 3 (EC 3.4.21.-) (Serine protease TADG- 12) (Tumor-associated differentially-expressed gene 12 protein).

GRN_MOUSE
NC score	0.059449 (rank : 103)	θ value	θ > 10 (rank : 110)
Query Neighborhood Hits	68	Target Neighborhood Hits	248	Shared Neighborhood Hits	22
SwissProt Accessions	P28798	Gene names	Grn
Domain Architecture
Description	Granulins precursor (Proepithelin) (PEPI) (PC cell-derived growth factor) (PCDGF) [Contains: Acrogranin; Granulin-1; Granulin-2; Granulin-3; Granulin-4; Granulin-5; Granulin-6; Granulin-7].

FBN3_HUMAN
NC score	0.059205 (rank : 104)	θ value	θ > 10 (rank : 104)
Query Neighborhood Hits	68	Target Neighborhood Hits	543	Shared Neighborhood Hits	31
SwissProt Accessions	Q75N90, Q75N91, Q75N92, Q75N93, Q86SJ5, Q96JP8	Gene names	FBN3, KIAA1776
Domain Architecture	No domain graphic available
Description	Fibrillin-3 precursor.

LTB1L_MOUSE
NC score	0.058945 (rank : 105)	θ value	θ > 10 (rank : 121)
Query Neighborhood Hits	68	Target Neighborhood Hits	514	Shared Neighborhood Hits	36
SwissProt Accessions	Q8CG19, O88349, Q8BNW7, Q8C7F5, Q8CIR0	Gene names	Ltbp1
Domain Architecture
Description	Latent-transforming growth factor beta-binding protein, isoform 1L precursor (LTBP-1) (Transforming growth factor beta-1-binding protein 1) (TGF-beta1-BP-1).

FBN2_HUMAN
NC score	0.058474 (rank : 106)	θ value	θ > 10 (rank : 102)
Query Neighborhood Hits	68	Target Neighborhood Hits	560	Shared Neighborhood Hits	33
SwissProt Accessions	P35556	Gene names	FBN2
Domain Architecture
Description	Fibrillin-2 precursor.

TLL1_MOUSE
NC score	0.058048 (rank : 107)	θ value	θ > 10 (rank : 165)
Query Neighborhood Hits	68	Target Neighborhood Hits	237	Shared Neighborhood Hits	27
SwissProt Accessions	Q62381, Q3UTT9, Q8BNP5	Gene names	Tll1, Tll
Domain Architecture	No domain graphic available
Description	Tolloid-like protein 1 precursor (EC 3.4.24.-) (mTll).

FBLN5_HUMAN
NC score	0.057928 (rank : 108)	θ value	θ > 10 (rank : 98)
Query Neighborhood Hits	68	Target Neighborhood Hits	329	Shared Neighborhood Hits	29
SwissProt Accessions	Q9UBX5, O75966, Q6UWA3	Gene names	FBLN5, DANCE
Domain Architecture
Description	Fibulin-5 precursor (FIBL-5) (Developmental arteries and neural crest EGF-like protein) (Dance) (Urine p50 protein) (UP50).

FBN2_MOUSE
NC score	0.057924 (rank : 109)	θ value	θ > 10 (rank : 103)
Query Neighborhood Hits	68	Target Neighborhood Hits	549	Shared Neighborhood Hits	33
SwissProt Accessions	Q61555, Q63957	Gene names	Fbn2, Fbn-2
Domain Architecture
Description	Fibrillin-2 precursor.

TLL1_HUMAN
NC score	0.057882 (rank : 110)	θ value	θ > 10 (rank : 164)
Query Neighborhood Hits	68	Target Neighborhood Hits	236	Shared Neighborhood Hits	27
SwissProt Accessions	O43897, Q96AN3, Q9NQS4	Gene names	TLL1, TLL
Domain Architecture	No domain graphic available
Description	Tolloid-like protein 1 precursor (EC 3.4.24.-).

LTB1S_MOUSE
NC score	0.057857 (rank : 111)	θ value	θ > 10 (rank : 123)
Query Neighborhood Hits	68	Target Neighborhood Hits	479	Shared Neighborhood Hits	33
SwissProt Accessions	Q8CG18, Q8BNW7, Q8C7F5, Q8CIR0	Gene names	Ltbp1
Domain Architecture
Description	Latent-transforming growth factor beta-binding protein, isoform 1S precursor (LTBP-1) (Transforming growth factor beta-1-binding protein 1) (TGF-beta1-BP-1).

PDZD8_HUMAN
NC score	0.057634 (rank : 112)	θ value	2.36792 (rank : 53)
Query Neighborhood Hits	68	Target Neighborhood Hits	185	Shared Neighborhood Hits	5
SwissProt Accessions	Q8NEN9, Q86WE0, Q86WE5, Q9UFF1	Gene names	PDZD8, PDZK8
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 8 (Sarcoma antigen NY-SAR-84/NY-SAR- 104).

FBLN5_MOUSE
NC score	0.057392 (rank : 113)	θ value	θ > 10 (rank : 99)
Query Neighborhood Hits	68	Target Neighborhood Hits	317	Shared Neighborhood Hits	26
SwissProt Accessions	Q9WVH9, Q541Z7	Gene names	Fbln5, Dance
Domain Architecture
Description	Fibulin-5 precursor (FIBL-5) (Developmental arteries and neural crest EGF-like protein) (Dance).

C1QR1_MOUSE
NC score	0.056638 (rank : 114)	θ value	θ > 10 (rank : 72)
Query Neighborhood Hits	68	Target Neighborhood Hits	342	Shared Neighborhood Hits	24
SwissProt Accessions	O89103, Q3U2X0	Gene names	Cd93, Aa4, C1qr1, C1qrp, Ly68
Domain Architecture
Description	Complement component C1q receptor precursor (Complement component 1 q subcomponent receptor 1) (C1qRp) (C1qR(p)) (C1q/MBL/SPA receptor) (CD93 antigen) (Cell surface antigen AA4) (Lymphocyte antigen 68).

TMPS2_HUMAN
NC score	0.056634 (rank : 115)	θ value	θ > 10 (rank : 168)
Query Neighborhood Hits	68	Target Neighborhood Hits	252	Shared Neighborhood Hits	40
SwissProt Accessions	O15393, Q9BXX1	Gene names	TMPRSS2, PRSS10
Domain Architecture
Description	Transmembrane protease, serine 2 precursor (EC 3.4.21.-) [Contains: Transmembrane protease, serine 2 non-catalytic chain; Transmembrane protease, serine 2 catalytic chain].

MATN2_HUMAN
NC score	0.056512 (rank : 116)	θ value	θ > 10 (rank : 133)
Query Neighborhood Hits	68	Target Neighborhood Hits	365	Shared Neighborhood Hits	27
SwissProt Accessions	O00339, Q6UWA5, Q7Z5X1, Q8NDE6, Q96FT5, Q9NSZ1	Gene names	MATN2
Domain Architecture
Description	Matrilin-2 precursor.

BMP1_MOUSE
NC score	0.055971 (rank : 117)	θ value	θ > 10 (rank : 70)
Query Neighborhood Hits	68	Target Neighborhood Hits	236	Shared Neighborhood Hits	28
SwissProt Accessions	P98063	Gene names	Bmp1
Domain Architecture
Description	Bone morphogenetic protein 1 precursor (EC 3.4.24.19) (BMP-1) (Procollagen C-proteinase) (PCP) (Mammalian tolloid protein) (mTld).

PROZ_MOUSE
NC score	0.055853 (rank : 118)	θ value	θ > 10 (rank : 157)
Query Neighborhood Hits	68	Target Neighborhood Hits	410	Shared Neighborhood Hits	30
SwissProt Accessions	Q9CQW3	Gene names	Proz
Domain Architecture
Description	Vitamin K-dependent protein Z precursor.

CUBN_MOUSE
NC score	0.055788 (rank : 119)	θ value	θ > 10 (rank : 81)
Query Neighborhood Hits	68	Target Neighborhood Hits	477	Shared Neighborhood Hits	39
SwissProt Accessions	Q9JLB4	Gene names	Cubn, Ifcr
Domain Architecture	No domain graphic available
Description	Cubilin precursor (Intrinsic factor-cobalamin receptor).

TLL2_MOUSE
NC score	0.055782 (rank : 120)	θ value	θ > 10 (rank : 167)
Query Neighborhood Hits	68	Target Neighborhood Hits	240	Shared Neighborhood Hits	28
SwissProt Accessions	Q9WVM6	Gene names	Tll2
Domain Architecture	No domain graphic available
Description	Tolloid-like protein 2 precursor (EC 3.4.24.-).

BMP1_HUMAN
NC score	0.055692 (rank : 121)	θ value	θ > 10 (rank : 69)
Query Neighborhood Hits	68	Target Neighborhood Hits	233	Shared Neighborhood Hits	28
SwissProt Accessions	P13497, Q13292, Q13872, Q14874, Q99421, Q99422, Q99423, Q9UL38	Gene names	BMP1, PCOLC
Domain Architecture
Description	Bone morphogenetic protein 1 precursor (EC 3.4.24.19) (BMP-1) (Procollagen C-proteinase) (PCP) (Mammalian tolloid protein) (mTld).

MEGF6_HUMAN
NC score	0.055650 (rank : 122)	θ value	θ > 10 (rank : 137)
Query Neighborhood Hits	68	Target Neighborhood Hits	671	Shared Neighborhood Hits	36
SwissProt Accessions	O75095, Q5VV39	Gene names	MEGF6, EGFL3, KIAA0815
Domain Architecture	No domain graphic available
Description	Multiple epidermal growth factor-like domains 6 precursor (EGF-like domain-containing protein 3) (Multiple EGF-like domain protein 3).

PERF_MOUSE
NC score	0.055599 (rank : 123)	θ value	θ > 10 (rank : 152)
Query Neighborhood Hits	68	Target Neighborhood Hits	45	Shared Neighborhood Hits	8
SwissProt Accessions	P10820	Gene names	Prf1, Pfp
Domain Architecture
Description	Perforin-1 precursor (P1) (Lymphocyte pore-forming protein) (Cytolysin).

RXFP2_HUMAN
NC score	0.055524 (rank : 124)	θ value	θ > 10 (rank : 158)
Query Neighborhood Hits	68	Target Neighborhood Hits	736	Shared Neighborhood Hits	48
SwissProt Accessions	Q8WXD0	Gene names	RXFP2, GPR106, GREAT, LGR8
Domain Architecture
Description	Relaxin receptor 2 (Relaxin family peptide receptor 2) (Leucine-rich repeat-containing G-protein coupled receptor 8) (G-protein coupled receptor affecting testicular descent) (G-protein coupled receptor 106).

TMPS3_MOUSE
NC score	0.054814 (rank : 125)	θ value	θ > 10 (rank : 171)
Query Neighborhood Hits	68	Target Neighborhood Hits	239	Shared Neighborhood Hits	43
SwissProt Accessions	Q8K1T0, Q8VDE0	Gene names	Tmprss3
Domain Architecture
Description	Transmembrane protease, serine 3 (EC 3.4.21.-).

JAG2_MOUSE
NC score	0.054720 (rank : 126)	θ value	θ > 10 (rank : 116)
Query Neighborhood Hits	68	Target Neighborhood Hits	504	Shared Neighborhood Hits	38
SwissProt Accessions	Q9QYE5, O55139, O70219	Gene names	Jag2
Domain Architecture
Description	Jagged-2 precursor (Jagged2).

TLL2_HUMAN
NC score	0.054709 (rank : 127)	θ value	θ > 10 (rank : 166)
Query Neighborhood Hits	68	Target Neighborhood Hits	241	Shared Neighborhood Hits	28
SwissProt Accessions	Q9Y6L7, Q6PJN5, Q9UQ00	Gene names	TLL2, KIAA0932
Domain Architecture	No domain graphic available
Description	Tolloid-like protein 2 precursor (EC 3.4.24.-).

JAG2_HUMAN
NC score	0.054500 (rank : 128)	θ value	θ > 10 (rank : 115)
Query Neighborhood Hits	68	Target Neighborhood Hits	491	Shared Neighborhood Hits	35
SwissProt Accessions	Q9Y219, Q9UE17, Q9UE99, Q9UNK8, Q9Y6P9, Q9Y6Q0	Gene names	JAG2
Domain Architecture
Description	Jagged-2 precursor (Jagged2) (HJ2).

FBLN4_MOUSE
NC score	0.054198 (rank : 129)	θ value	θ > 10 (rank : 97)
Query Neighborhood Hits	68	Target Neighborhood Hits	270	Shared Neighborhood Hits	23
SwissProt Accessions	Q9WVJ9	Gene names	Efemp2, Fbln4, Mbp1
Domain Architecture
Description	EGF-containing fibulin-like extracellular matrix protein 2 precursor (Fibulin-4) (FIBL-4) (Mutant p53-binding protein 1).

MASP1_HUMAN
NC score	0.054133 (rank : 130)	θ value	θ > 10 (rank : 129)
Query Neighborhood Hits	68	Target Neighborhood Hits	369	Shared Neighborhood Hits	33
SwissProt Accessions	P48740, O95570, Q9UF09	Gene names	MASP1, CRARF, CRARF1, PRSS5
Domain Architecture
Description	Complement-activating component of Ra-reactive factor precursor (EC 3.4.21.-) (Ra-reactive factor serine protease p100) (RaRF) (Mannan-binding lectin serine protease 1) (Mannose-binding protein- associated serine protease) (MASP-1) [Contains: Complement-activating component of Ra-reactive factor heavy chain; Complement-activating component of Ra-reactive factor light chain].

FBLN4_HUMAN
NC score	0.054122 (rank : 131)	θ value	θ > 10 (rank : 96)
Query Neighborhood Hits	68	Target Neighborhood Hits	278	Shared Neighborhood Hits	24
SwissProt Accessions	O95967, O75967	Gene names	EFEMP2, FBLN4
Domain Architecture
Description	EGF-containing fibulin-like extracellular matrix protein 2 precursor (Fibulin-4) (FIBL-4) (UPH1 protein).

LTBP4_MOUSE
NC score	0.053976 (rank : 132)	θ value	θ > 10 (rank : 128)
Query Neighborhood Hits	68	Target Neighborhood Hits	607	Shared Neighborhood Hits	34
SwissProt Accessions	Q8K4G1, Q8K4G0	Gene names	Ltbp4
Domain Architecture
Description	Latent-transforming growth factor beta-binding protein 4 precursor (LTBP-4).

FBLN3_HUMAN
NC score	0.053880 (rank : 133)	θ value	θ > 10 (rank : 94)
Query Neighborhood Hits	68	Target Neighborhood Hits	293	Shared Neighborhood Hits	27
SwissProt Accessions	Q12805	Gene names	EFEMP1, FBLN3, FBNL
Domain Architecture
Description	EGF-containing fibulin-like extracellular matrix protein 1 precursor (Fibulin-3) (FIBL-3) (Fibrillin-like protein) (Extracellular protein S1-5).

MASP2_HUMAN
NC score	0.053303 (rank : 134)	θ value	θ > 10 (rank : 131)
Query Neighborhood Hits	68	Target Neighborhood Hits	364	Shared Neighborhood Hits	33
SwissProt Accessions	O00187, O75754, Q5TEQ5, Q5TER0, Q96QG4, Q9BZH0, Q9H498, Q9H499, Q9UBP3, Q9ULC7, Q9UMV3, Q9Y270	Gene names	MASP2
Domain Architecture
Description	Mannan-binding lectin serine protease 2 precursor (EC 3.4.21.104) (Mannose-binding protein-associated serine protease 2) (MASP-2) (MBL- associated serine protease 2) [Contains: Mannan-binding lectin serine protease 2 A chain; Mannan-binding lectin serine protease 2 B chain].

CREL1_MOUSE
NC score	0.053218 (rank : 135)	θ value	θ > 10 (rank : 79)
Query Neighborhood Hits	68	Target Neighborhood Hits	524	Shared Neighborhood Hits	24
SwissProt Accessions	Q91XD7, Q8BGJ8	Gene names	Creld1
Domain Architecture	No domain graphic available
Description	Cysteine-rich with EGF-like domain protein 1 precursor.

LCE3B_HUMAN
NC score	0.053163 (rank : 136)	θ value	θ > 10 (rank : 118)
Query Neighborhood Hits	68	Target Neighborhood Hits	47	Shared Neighborhood Hits	9
SwissProt Accessions	Q5TA77	Gene names	LCE3B, LEP14
Domain Architecture	No domain graphic available
Description	Late cornified envelope protein 3B (Late envelope protein 14).

MATN4_HUMAN
NC score	0.053147 (rank : 137)	θ value	θ > 10 (rank : 135)
Query Neighborhood Hits	68	Target Neighborhood Hits	287	Shared Neighborhood Hits	24
SwissProt Accessions	O95460, Q5QPU2, Q5QPU3, Q5QPU4, Q8N2M5, Q8N2M7, Q9H1F8, Q9H1F9	Gene names	MATN4
Domain Architecture
Description	Matrilin-4 precursor.

DLL1_MOUSE
NC score	0.053143 (rank : 138)	θ value	θ > 10 (rank : 83)
Query Neighborhood Hits	68	Target Neighborhood Hits	456	Shared Neighborhood Hits	37
SwissProt Accessions	Q61483	Gene names	Dll1
Domain Architecture
Description	Delta-like protein 1 precursor (Drosophila Delta homolog 1) (Delta1).

PROC_MOUSE
NC score	0.053024 (rank : 139)	θ value	θ > 10 (rank : 153)
Query Neighborhood Hits	68	Target Neighborhood Hits	426	Shared Neighborhood Hits	33
SwissProt Accessions	P33587, O35498, Q91WN8, Q99PC6	Gene names	Proc
Domain Architecture
Description	Vitamin K-dependent protein C precursor (EC 3.4.21.69) (Autoprothrombin IIA) (Anticoagulant protein C) (Blood coagulation factor XIV) [Contains: Vitamin K-dependent protein C light chain; Vitamin K-dependent protein C heavy chain; Activation peptide].

DLL1_HUMAN
NC score	0.052916 (rank : 140)	θ value	θ > 10 (rank : 82)
Query Neighborhood Hits	68	Target Neighborhood Hits	455	Shared Neighborhood Hits	40
SwissProt Accessions	O00548, Q9NU41, Q9UJV2	Gene names	DLL1
Domain Architecture
Description	Delta-like protein 1 precursor (Drosophila Delta homolog 1) (Delta1) (H-Delta-1).

CREL1_HUMAN
NC score	0.052835 (rank : 141)	θ value	θ > 10 (rank : 78)
Query Neighborhood Hits	68	Target Neighborhood Hits	441	Shared Neighborhood Hits	22
SwissProt Accessions	Q96HD1, Q6I9X5, Q8NFT4, Q9Y409	Gene names	CRELD1, CIRRIN
Domain Architecture	No domain graphic available
Description	Cysteine-rich with EGF-like domain protein 1 precursor.

MATN4_MOUSE
NC score	0.052815 (rank : 142)	θ value	θ > 10 (rank : 136)
Query Neighborhood Hits	68	Target Neighborhood Hits	277	Shared Neighborhood Hits	26
SwissProt Accessions	O89029, O89030, Q9QWS3	Gene names	Matn4
Domain Architecture
Description	Matrilin-4 precursor (MAT-4).

LTBP3_MOUSE
NC score	0.052581 (rank : 143)	θ value	θ > 10 (rank : 127)
Query Neighborhood Hits	68	Target Neighborhood Hits	475	Shared Neighborhood Hits	33
SwissProt Accessions	Q61810, Q8BNQ6	Gene names	Ltbp3
Domain Architecture
Description	Latent-transforming growth factor beta-binding protein 3 precursor (LTBP-3).

C1RA_MOUSE
NC score	0.052393 (rank : 144)	θ value	θ > 10 (rank : 73)
Query Neighborhood Hits	68	Target Neighborhood Hits	379	Shared Neighborhood Hits	35
SwissProt Accessions	Q8CG16, Q99KI6, Q9ET60	Gene names	C1ra, C1r
Domain Architecture
Description	Complement C1r-A subcomponent precursor (EC 3.4.21.41) (Complement component 1, r-A subcomponent) [Contains: Complement C1r-A subcomponent heavy chain; Complement C1r-A subcomponent light chain].

MASP1_MOUSE
NC score	0.052316 (rank : 145)	θ value	θ > 10 (rank : 130)
Query Neighborhood Hits	68	Target Neighborhood Hits	364	Shared Neighborhood Hits	32
SwissProt Accessions	P98064	Gene names	Masp1, Crarf
Domain Architecture
Description	Complement-activating component of Ra-reactive factor precursor (EC 3.4.21.-) (Ra-reactive factor serine protease p100) (RaRF) (Mannan-binding lectin serine protease 1) [Contains: Complement- activating component of Ra-reactive factor heavy chain; Complement- activating component of Ra-reactive factor light chain].

FA9_HUMAN
NC score	0.052286 (rank : 146)	θ value	θ > 10 (rank : 89)
Query Neighborhood Hits	68	Target Neighborhood Hits	421	Shared Neighborhood Hits	37
SwissProt Accessions	P00740	Gene names	F9
Domain Architecture
Description	Coagulation factor IX precursor (EC 3.4.21.22) (Christmas factor) (Plasma thromboplastin component) (PTC) [Contains: Coagulation factor IXa light chain; Coagulation factor IXa heavy chain].

LTBP2_MOUSE
NC score	0.052091 (rank : 147)	θ value	θ > 10 (rank : 125)
Query Neighborhood Hits	68	Target Neighborhood Hits	617	Shared Neighborhood Hits	31
SwissProt Accessions	O08999, Q8C6W9	Gene names	Ltbp2
Domain Architecture
Description	Latent-transforming growth factor beta-binding protein 2 precursor (LTBP-2).

NELL2_HUMAN
NC score	0.052032 (rank : 148)	θ value	θ > 10 (rank : 141)
Query Neighborhood Hits	68	Target Neighborhood Hits	449	Shared Neighborhood Hits	30
SwissProt Accessions	Q99435	Gene names	NELL2, NRP2
Domain Architecture
Description	Protein kinase C-binding protein NELL2 precursor (NEL-like protein 2) (Nel-related protein 2).

LTBP3_HUMAN
NC score	0.051967 (rank : 149)	θ value	θ > 10 (rank : 126)
Query Neighborhood Hits	68	Target Neighborhood Hits	502	Shared Neighborhood Hits	31
SwissProt Accessions	Q9NS15, O15107, Q96HB9, Q9H7K2, Q9UFN4	Gene names	LTBP3
Domain Architecture
Description	Latent-transforming growth factor beta-binding protein 3 precursor (LTBP-3).

C1RB_MOUSE
NC score	0.051664 (rank : 150)	θ value	θ > 10 (rank : 74)
Query Neighborhood Hits	68	Target Neighborhood Hits	380	Shared Neighborhood Hits	34
SwissProt Accessions	Q8CFG9	Gene names	C1rb, C1r
Domain Architecture	No domain graphic available
Description	Complement C1r-B subcomponent precursor (EC 3.4.21.41) (Complement component 1, r-B subcomponent) [Contains: Complement C1r-B subcomponent heavy chain; Complement C1r-B subcomponent light chain].

JAG1_MOUSE
NC score	0.051646 (rank : 151)	θ value	θ > 10 (rank : 114)
Query Neighborhood Hits	68	Target Neighborhood Hits	518	Shared Neighborhood Hits	34
SwissProt Accessions	Q9QXX0	Gene names	Jag1
Domain Architecture
Description	Jagged-1 precursor (Jagged1) (CD339 antigen).

C1R_HUMAN
NC score	0.051555 (rank : 152)	θ value	θ > 10 (rank : 75)
Query Neighborhood Hits	68	Target Neighborhood Hits	364	Shared Neighborhood Hits	32
SwissProt Accessions	P00736, Q8J012	Gene names	C1R
Domain Architecture
Description	Complement C1r subcomponent precursor (EC 3.4.21.41) (Complement component 1, r subcomponent) [Contains: Complement C1r subcomponent heavy chain; Complement C1r subcomponent light chain].

NOTC1_MOUSE
NC score	0.051458 (rank : 153)	θ value	θ > 10 (rank : 151)
Query Neighborhood Hits	68	Target Neighborhood Hits	916	Shared Neighborhood Hits	40
SwissProt Accessions	Q01705, Q06007, Q61905, Q99JC2, Q9QW58, Q9R0X7	Gene names	Notch1, Motch
Domain Architecture
Description	Neurogenic locus notch homolog protein 1 precursor (Notch 1) (Motch A) (mT14) (p300) [Contains: Notch 1 extracellular truncation; Notch 1 intracellular domain].

FBLN3_MOUSE
NC score	0.051388 (rank : 154)	θ value	θ > 10 (rank : 95)
Query Neighborhood Hits	68	Target Neighborhood Hits	279	Shared Neighborhood Hits	25
SwissProt Accessions	Q8BPB5, Q6Y3N6	Gene names	Efemp1, Fbln3
Domain Architecture	No domain graphic available
Description	EGF-containing fibulin-like extracellular matrix protein 1 precursor (Fibulin-3) (FIBL-3).

FA10_MOUSE
NC score	0.051310 (rank : 155)	θ value	θ > 10 (rank : 88)
Query Neighborhood Hits	68	Target Neighborhood Hits	435	Shared Neighborhood Hits	36
SwissProt Accessions	O88947, O54740, Q99L32	Gene names	F10
Domain Architecture
Description	Coagulation factor X precursor (EC 3.4.21.6) (Stuart factor) [Contains: Factor X light chain; Factor X heavy chain; Activated factor Xa heavy chain].

NELL2_MOUSE
NC score	0.051148 (rank : 156)	θ value	θ > 10 (rank : 142)
Query Neighborhood Hits	68	Target Neighborhood Hits	436	Shared Neighborhood Hits	27
SwissProt Accessions	Q61220	Gene names	Nell2, Mel91
Domain Architecture
Description	Protein kinase C-binding protein NELL2 precursor (NEL-like protein 2) (MEL91 protein).

MASP2_MOUSE
NC score	0.051097 (rank : 157)	θ value	θ > 10 (rank : 132)
Query Neighborhood Hits	68	Target Neighborhood Hits	382	Shared Neighborhood Hits	32
SwissProt Accessions	Q91WP0, Q9QXA4, Q9QXD2, Q9QXD5, Q9Z338	Gene names	Masp2
Domain Architecture	No domain graphic available
Description	Mannan-binding lectin serine protease 2 precursor (EC 3.4.21.104) (Mannose-binding protein-associated serine protease 2) (MASP-2) (MBL- associated serine protease 2) [Contains: Mannan-binding lectin serine protease 2 A chain; Mannan-binding lectin serine protease 2 B chain].

EGFL7_HUMAN
NC score	0.051005 (rank : 158)	θ value	θ > 10 (rank : 84)
Query Neighborhood Hits	68	Target Neighborhood Hits	325	Shared Neighborhood Hits	20
SwissProt Accessions	Q9UHF1, Q5M7Y5, Q5VUD5, Q96EG0	Gene names	EGFL7, MEGF7
Domain Architecture	No domain graphic available
Description	EGF-like domain-containing protein 7 precursor (Multiple EGF-like domain protein 7) (Multiple epidermal growth factor-like domain protein 7) (Vascular endothelial statin) (VE-statin) (NOTCH4-like protein) (ZNEU1).

MATN2_MOUSE
NC score	0.050739 (rank : 159)	θ value	θ > 10 (rank : 134)
Query Neighborhood Hits	68	Target Neighborhood Hits	356	Shared Neighborhood Hits	25
SwissProt Accessions	O08746	Gene names	Matn2
Domain Architecture
Description	Matrilin-2 precursor.

JAG1_HUMAN
NC score	0.050711 (rank : 160)	θ value	θ > 10 (rank : 113)
Query Neighborhood Hits	68	Target Neighborhood Hits	514	Shared Neighborhood Hits	34
SwissProt Accessions	P78504, O14902, O15122, Q15816	Gene names	JAG1, JAGL1
Domain Architecture
Description	Jagged-1 precursor (Jagged1) (hJ1) (CD339 antigen).

KR107_HUMAN
NC score	0.050635 (rank : 161)	θ value	θ > 10 (rank : 117)
Query Neighborhood Hits	68	Target Neighborhood Hits	330	Shared Neighborhood Hits	25
SwissProt Accessions	P60409, Q70LJ2	Gene names	KRTAP10-7, KAP10.7, KAP18-7, KRTAP10.7, KRTAP18-7, KRTAP18.7
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 10-7 (Keratin-associated protein 10.7) (High sulfur keratin-associated protein 10.7) (Keratin-associated protein 18-7) (Keratin-associated protein 18.7).

CRUM1_HUMAN
NC score	0.050373 (rank : 162)	θ value	θ > 10 (rank : 80)
Query Neighborhood Hits	68	Target Neighborhood Hits	457	Shared Neighborhood Hits	35
SwissProt Accessions	P82279, Q5K3A6, Q5TC28, Q5VUT1, Q6N027, Q8WWY0	Gene names	CRB1
Domain Architecture
Description	Crumbs homolog 1 precursor.

NELL1_HUMAN
NC score	0.050089 (rank : 163)	θ value	θ > 10 (rank : 140)
Query Neighborhood Hits	68	Target Neighborhood Hits	451	Shared Neighborhood Hits	26
SwissProt Accessions	Q92832, Q9Y472	Gene names	NELL1, NRP1
Domain Architecture
Description	Protein kinase C-binding protein NELL1 precursor (NEL-like protein 1) (Nel-related protein 1).

MINT_HUMAN
NC score	0.036312 (rank : 164)	θ value	0.47712 (rank : 39)
Query Neighborhood Hits	68	Target Neighborhood Hits	1291	Shared Neighborhood Hits	9
SwissProt Accessions	Q96T58, Q9H9A8, Q9NWH5, Q9UQ01, Q9Y556	Gene names	SPEN, KIAA0929, MINT, SHARP
Domain Architecture
Description	Msx2-interacting protein (SPEN homolog) (SMART/HDAC1-associated repressor protein).

GSCR1_HUMAN
NC score	0.035836 (rank : 165)	θ value	6.88961 (rank : 65)
Query Neighborhood Hits	68	Target Neighborhood Hits	674	Shared Neighborhood Hits	8
SwissProt Accessions	Q9NZM4	Gene names	GLTSCR1
Domain Architecture	No domain graphic available
Description	Glioma tumor suppressor candidate region gene 1 protein.

MINT_MOUSE
NC score	0.035067 (rank : 166)	θ value	0.47712 (rank : 40)
Query Neighborhood Hits	68	Target Neighborhood Hits	1514	Shared Neighborhood Hits	10
SwissProt Accessions	Q62504, Q80TN9, Q99PS4, Q9QZW2	Gene names	Spen, Kiaa0929, Mint, Sharp
Domain Architecture
Description	Msx2-interacting protein (SPEN homolog) (SMART/HDAC1-associated repressor protein).

ATS9_HUMAN
NC score	0.025839 (rank : 167)	θ value	5.27518 (rank : 60)
Query Neighborhood Hits	68	Target Neighborhood Hits	219	Shared Neighborhood Hits	19
SwissProt Accessions	Q9P2N4, Q9NR29	Gene names	ADAMTS9, KIAA1312
Domain Architecture
Description	ADAMTS-9 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase with thrombospondin motifs 9) (ADAM-TS 9) (ADAM-TS9).

5NT1B_MOUSE
NC score	0.021115 (rank : 168)	θ value	3.0926 (rank : 54)
Query Neighborhood Hits	68	Target Neighborhood Hits	78	Shared Neighborhood Hits	3
SwissProt Accessions	Q91YE9, Q91Y48	Gene names	Nt5c1b, Airp
Domain Architecture
Description	Cytosolic 5'-nucleotidase 1B (EC 3.1.3.5) (Cytosolic 5'-nucleotidase IB) (cN1B) (cN-IB) (Autoimmune infertility-related protein).

CELR2_HUMAN
NC score	0.018162 (rank : 169)	θ value	8.99809 (rank : 67)
Query Neighborhood Hits	68	Target Neighborhood Hits	657	Shared Neighborhood Hits	26
SwissProt Accessions	Q9HCU4, Q92566	Gene names	CELSR2, CDHF10, EGFL2, KIAA0279, MEGF3
Domain Architecture
Description	Cadherin EGF LAG seven-pass G-type receptor 2 precursor (Epidermal growth factor-like 2) (Multiple epidermal growth factor-like domains 3) (Flamingo 1).

MCP_MOUSE
NC score	0.017796 (rank : 170)	θ value	5.27518 (rank : 62)
Query Neighborhood Hits	68	Target Neighborhood Hits	79	Shared Neighborhood Hits	4
SwissProt Accessions	O88174, Q9R0R9	Gene names	Cd46, Mcp
Domain Architecture	No domain graphic available
Description	Membrane cofactor protein precursor (CD46 antigen).

LPIN3_HUMAN
NC score	0.014259 (rank : 171)	θ value	8.99809 (rank : 68)
Query Neighborhood Hits	68	Target Neighborhood Hits	92	Shared Neighborhood Hits	4
SwissProt Accessions	Q9BQK8, Q5TDB9, Q9NPY8, Q9UJE5	Gene names	LPIN3, LIPN3L
Domain Architecture	No domain graphic available
Description	Lipin-3 (Lipin 3-like).

CELR2_MOUSE
NC score	0.013648 (rank : 172)	θ value	6.88961 (rank : 64)
Query Neighborhood Hits	68	Target Neighborhood Hits	584	Shared Neighborhood Hits	18
SwissProt Accessions	Q9R0M0, Q99K26, Q9Z2R4	Gene names	Celsr2
Domain Architecture
Description	Cadherin EGF LAG seven-pass G-type receptor 2 precursor (Flamingo 1) (mFmi1).

SMAD4_MOUSE
NC score	0.009630 (rank : 173)	θ value	5.27518 (rank : 63)
Query Neighborhood Hits	68	Target Neighborhood Hits	101	Shared Neighborhood Hits	2
SwissProt Accessions	P97471, Q9CW56	Gene names	Smad4, Dpc4, Madh4
Domain Architecture
Description	Mothers against decapentaplegic homolog 4 (SMAD 4) (Mothers against DPP homolog 4) (Deletion target in pancreatic carcinoma 4 homolog) (Smad4).

CASR_MOUSE
NC score	0.009621 (rank : 174)	θ value	3.0926 (rank : 55)
Query Neighborhood Hits	68	Target Neighborhood Hits	72	Shared Neighborhood Hits	4
SwissProt Accessions	Q9QY96, O08968, O88519, Q9QY95, Q9QZU8, Q9R1D6, Q9R1Y2	Gene names	Casr, Gprc2a
Domain Architecture
Description	Extracellular calcium-sensing receptor precursor (CaSR) (Parathyroid Cell calcium-sensing receptor).

GPR63_MOUSE
NC score	0.001264 (rank : 175)	θ value	4.03905 (rank : 57)
Query Neighborhood Hits	68	Target Neighborhood Hits	774	Shared Neighborhood Hits	2
SwissProt Accessions	Q9EQQ3	Gene names	Gpr63
Domain Architecture
Description	Probable G-protein coupled receptor 63 (PSP24-beta) (PSP24-2).