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Network neighborhood for query Sequence : NR4A1_MOUSE

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NR4A1_MOUSE
SwissProt Accessions	P12813	Gene names	Nr4a1, Gfrp, Hmr, N10, Nur77
Domain Architecture
Description	Orphan nuclear receptor NR4A1 (Orphan nuclear receptor HMR) (Nuclear hormone receptor NUR/77) (N10 nuclear protein).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

NR4A1_HUMAN
θ value	0 (rank : 1)	NC score	0.997808 (rank : 2)
Query Neighborhood Hits	128	Target Neighborhood Hits	133	Shared Neighborhood Hits	105
SwissProt Accessions	P22736	Gene names	NR4A1, GFRP1, HMR, NAK1
Domain Architecture
Description	Orphan nuclear receptor NR4A1 (Orphan nuclear receptor HMR) (Early response protein NAK1) (TR3 orphan receptor) (ST-59).

NR4A1_MOUSE
θ value	0 (rank : 2)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	128	Target Neighborhood Hits	128	Shared Neighborhood Hits	128
SwissProt Accessions	P12813	Gene names	Nr4a1, Gfrp, Hmr, N10, Nur77
Domain Architecture
Description	Orphan nuclear receptor NR4A1 (Orphan nuclear receptor HMR) (Nuclear hormone receptor NUR/77) (N10 nuclear protein).

NR4A2_HUMAN
θ value	1.37464e-149 (rank : 3)	NC score	0.993561 (rank : 3)
Query Neighborhood Hits	128	Target Neighborhood Hits	120	Shared Neighborhood Hits	94
SwissProt Accessions	P43354, Q16311	Gene names	NR4A2, NOT, NURR1, TINUR
Domain Architecture
Description	Orphan nuclear receptor NR4A2 (Orphan nuclear receptor NURR1) (Immediate-early response protein NOT) (Transcriptionally-inducible nuclear receptor).

NR4A2_MOUSE
θ value	1.79534e-149 (rank : 4)	NC score	0.993557 (rank : 4)
Query Neighborhood Hits	128	Target Neighborhood Hits	121	Shared Neighborhood Hits	94
SwissProt Accessions	Q06219, O08690	Gene names	Nr4a2, Nurr1
Domain Architecture
Description	Orphan nuclear receptor NR4A2 (Orphan nuclear receptor NURR1) (NUR- related factor 1).

NR4A3_MOUSE
θ value	1.21547e-113 (rank : 5)	NC score	0.990755 (rank : 6)
Query Neighborhood Hits	128	Target Neighborhood Hits	127	Shared Neighborhood Hits	95
SwissProt Accessions	Q9QZB6, Q9QZB5	Gene names	Nr4a3, Tec
Domain Architecture
Description	Orphan nuclear receptor NR4A3 (Orphan nuclear receptor TEC) (Translocated in extraskeletal chondrosarcoma).

NR4A3_HUMAN
θ value	1.58745e-113 (rank : 6)	NC score	0.990817 (rank : 5)
Query Neighborhood Hits	128	Target Neighborhood Hits	131	Shared Neighborhood Hits	94
SwissProt Accessions	Q92570, Q12935, Q14979, Q16420, Q4VXA9, Q9UEK2, Q9UEK3	Gene names	NR4A3, CHN, CSMF, MINOR, NOR1, TEC
Domain Architecture
Description	Orphan nuclear receptor NR4A3 (Nuclear hormone receptor NOR-1) (Neuron-derived orphan receptor 1) (Mitogen-induced nuclear orphan receptor).

RARG1_MOUSE
θ value	4.40402e-47 (rank : 7)	NC score	0.955764 (rank : 11)
Query Neighborhood Hits	128	Target Neighborhood Hits	113	Shared Neighborhood Hits	94
SwissProt Accessions	P18911, Q91VK5	Gene names	Rarg, Nr1b3
Domain Architecture
Description	Retinoic acid receptor gamma-A (RAR-gamma-A).

RARG2_MOUSE
θ value	4.40402e-47 (rank : 8)	NC score	0.955964 (rank : 9)
Query Neighborhood Hits	128	Target Neighborhood Hits	114	Shared Neighborhood Hits	94
SwissProt Accessions	P20787	Gene names	Rarg, Nr1b3
Domain Architecture
Description	Retinoic acid receptor gamma-B (RAR-gamma-B).

RARB_MOUSE
θ value	1.28137e-46 (rank : 9)	NC score	0.956090 (rank : 7)
Query Neighborhood Hits	128	Target Neighborhood Hits	109	Shared Neighborhood Hits	96
SwissProt Accessions	P22605, P11417, P22604	Gene names	Rarb, Nr1b2
Domain Architecture
Description	Retinoic acid receptor beta (RAR-beta).

RARB_HUMAN
θ value	6.35935e-46 (rank : 10)	NC score	0.955643 (rank : 12)
Query Neighborhood Hits	128	Target Neighborhood Hits	118	Shared Neighborhood Hits	95
SwissProt Accessions	P10826, P12891, Q00989, Q15298, Q9UN48	Gene names	RARB, HAP, NR1B2
Domain Architecture
Description	Retinoic acid receptor beta (RAR-beta) (RAR-epsilon) (HBV-activated protein).

RARG1_HUMAN
θ value	1.08474e-45 (rank : 11)	NC score	0.955889 (rank : 10)
Query Neighborhood Hits	128	Target Neighborhood Hits	107	Shared Neighborhood Hits	94
SwissProt Accessions	P13631	Gene names	RARG, NR1B3
Domain Architecture
Description	Retinoic acid receptor gamma-1 (RAR-gamma-1).

RARG2_HUMAN
θ value	1.08474e-45 (rank : 12)	NC score	0.955981 (rank : 8)
Query Neighborhood Hits	128	Target Neighborhood Hits	109	Shared Neighborhood Hits	94
SwissProt Accessions	P22932, Q15281	Gene names	RARG, NR1B3
Domain Architecture	No domain graphic available
Description	Retinoic acid receptor gamma-2 (RAR-gamma-2).

RARA_HUMAN
θ value	7.03111e-45 (rank : 13)	NC score	0.955340 (rank : 13)
Query Neighborhood Hits	128	Target Neighborhood Hits	118	Shared Neighborhood Hits	94
SwissProt Accessions	P10276, P78456, Q13440, Q13441, Q9NQS0	Gene names	RARA, NR1B1
Domain Architecture
Description	Retinoic acid receptor alpha (RAR-alpha).

RARA_MOUSE
θ value	1.19932e-44 (rank : 14)	NC score	0.955324 (rank : 14)
Query Neighborhood Hits	128	Target Neighborhood Hits	113	Shared Neighborhood Hits	94
SwissProt Accessions	P11416, P22603	Gene names	Rara, Nr1b1
Domain Architecture
Description	Retinoic acid receptor alpha (RAR-alpha).

ERR3_HUMAN
θ value	2.50074e-42 (rank : 15)	NC score	0.952263 (rank : 15)
Query Neighborhood Hits	128	Target Neighborhood Hits	106	Shared Neighborhood Hits	94
SwissProt Accessions	P62508, O75454, O96021, Q68DA0, Q6P274, Q6PK28, Q6TS38, Q9R1F3, Q9UNJ4	Gene names	ESRRG, ERR3, ERRG2, KIAA0832, NR3B3
Domain Architecture	No domain graphic available
Description	Estrogen-related receptor gamma (Estrogen receptor-related protein 3) (ERR gamma-2).

ERR3_MOUSE
θ value	2.50074e-42 (rank : 16)	NC score	0.952263 (rank : 16)
Query Neighborhood Hits	128	Target Neighborhood Hits	106	Shared Neighborhood Hits	94
SwissProt Accessions	P62509, O75454, O96021, Q8CHC9, Q9R1F3	Gene names	Esrrg, Err3, Kiaa0832, Nr3b3
Domain Architecture	No domain graphic available
Description	Estrogen-related receptor gamma (Estrogen receptor-related protein 3).

ERR2_MOUSE
θ value	6.15952e-41 (rank : 17)	NC score	0.950931 (rank : 17)
Query Neighborhood Hits	128	Target Neighborhood Hits	109	Shared Neighborhood Hits	94
SwissProt Accessions	Q61539, O09067, O09146	Gene names	Esrrb, Err-2, Err2, Nr3b2
Domain Architecture
Description	Steroid hormone receptor ERR2 (Estrogen-related receptor, beta) (ERR- beta) (Estrogen receptor-like 2).

COT1_HUMAN
θ value	3.99248e-40 (rank : 18)	NC score	0.937073 (rank : 37)
Query Neighborhood Hits	128	Target Neighborhood Hits	159	Shared Neighborhood Hits	94
SwissProt Accessions	P10589	Gene names	NR2F1, EAR3, ERBAL3, TFCOUP1
Domain Architecture
Description	COUP transcription factor 1 (COUP-TF1) (COUP-TF I) (V-ERBA-related protein EAR-3).

COT1_MOUSE
θ value	3.99248e-40 (rank : 19)	NC score	0.937378 (rank : 33)
Query Neighborhood Hits	128	Target Neighborhood Hits	160	Shared Neighborhood Hits	94
SwissProt Accessions	Q60632, Q61438	Gene names	Nr2f1, Erbal3, Tfcoup1
Domain Architecture
Description	COUP transcription factor 1 (COUP-TF1) (COUP-TF I).

ERR2_HUMAN
θ value	3.99248e-40 (rank : 20)	NC score	0.950555 (rank : 18)
Query Neighborhood Hits	128	Target Neighborhood Hits	108	Shared Neighborhood Hits	94
SwissProt Accessions	O95718, Q9HCB4	Gene names	ESRRB, ERRB2, NR3B2
Domain Architecture
Description	Steroid hormone receptor ERR2 (Estrogen-related receptor, beta) (ERR- beta) (Estrogen receptor-like 2) (ERR beta-2).

COT2_HUMAN
θ value	8.89434e-40 (rank : 21)	NC score	0.938328 (rank : 29)
Query Neighborhood Hits	128	Target Neighborhood Hits	135	Shared Neighborhood Hits	94
SwissProt Accessions	P24468, Q03754	Gene names	NR2F2, ARP1, TFCOUP2
Domain Architecture
Description	COUP transcription factor 2 (COUP-TF2) (COUP-TF II) (Apolipoprotein AI regulatory protein 1) (ARP-1).

COT2_MOUSE
θ value	8.89434e-40 (rank : 22)	NC score	0.938328 (rank : 30)
Query Neighborhood Hits	128	Target Neighborhood Hits	135	Shared Neighborhood Hits	94
SwissProt Accessions	P43135	Gene names	Nr2f2, Aporp1, Arp-1, Arp1, Tfcoup2
Domain Architecture
Description	COUP transcription factor 2 (COUP-TF2) (COUP-TF II) (Apolipoprotein AI regulatory protein 1) (ARP-1).

ESR2_HUMAN
θ value	5.96599e-36 (rank : 23)	NC score	0.938776 (rank : 28)
Query Neighborhood Hits	128	Target Neighborhood Hits	110	Shared Neighborhood Hits	94
SwissProt Accessions	Q92731, O60608, O60685, O60702, O60703, O75583, O75584, Q86Z31, Q9UEV6, Q9UHD3, Q9UQK9	Gene names	ESR2, ESTRB, NR3A2
Domain Architecture
Description	Estrogen receptor beta (ER-beta).

RXRA_HUMAN
θ value	1.01765e-35 (rank : 24)	NC score	0.940157 (rank : 26)
Query Neighborhood Hits	128	Target Neighborhood Hits	223	Shared Neighborhood Hits	98
SwissProt Accessions	P19793, Q2V504	Gene names	RXRA, NR2B1
Domain Architecture
Description	Retinoic acid receptor RXR-alpha (Retinoid X receptor alpha).

EAR2_MOUSE
θ value	1.46948e-34 (rank : 25)	NC score	0.938135 (rank : 31)
Query Neighborhood Hits	128	Target Neighborhood Hits	104	Shared Neighborhood Hits	94
SwissProt Accessions	P43136, Q61504	Gene names	Nr2f6, Ear-2, Ear2, Erbal2
Domain Architecture
Description	Orphan nuclear receptor EAR-2 (V-erbA-related protein EAR-2).

NR1H3_HUMAN
θ value	1.9192e-34 (rank : 26)	NC score	0.943288 (rank : 22)
Query Neighborhood Hits	128	Target Neighborhood Hits	104	Shared Neighborhood Hits	94
SwissProt Accessions	Q13133, Q96H87	Gene names	NR1H3, LXRA
Domain Architecture
Description	Oxysterols receptor LXR-alpha (Liver X receptor alpha) (Nuclear orphan receptor LXR-alpha).

ESR2_MOUSE
θ value	3.27365e-34 (rank : 27)	NC score	0.938019 (rank : 32)
Query Neighborhood Hits	128	Target Neighborhood Hits	110	Shared Neighborhood Hits	94
SwissProt Accessions	O08537, O35635, O70519	Gene names	Esr2, Estrb, Nr3a2
Domain Architecture
Description	Estrogen receptor beta (ER-beta).

RXRA_MOUSE
θ value	4.27553e-34 (rank : 28)	NC score	0.942554 (rank : 24)
Query Neighborhood Hits	128	Target Neighborhood Hits	129	Shared Neighborhood Hits	94
SwissProt Accessions	P28700	Gene names	Rxra, Nr2b1
Domain Architecture
Description	Retinoic acid receptor RXR-alpha (Retinoid X receptor alpha).

NR1H3_MOUSE
θ value	7.29293e-34 (rank : 29)	NC score	0.943171 (rank : 23)
Query Neighborhood Hits	128	Target Neighborhood Hits	102	Shared Neighborhood Hits	94
SwissProt Accessions	Q9Z0Y9, Q9QUH7	Gene names	Nr1h3, Lxra
Domain Architecture
Description	Oxysterols receptor LXR-alpha (Liver X receptor alpha) (Nuclear orphan receptor LXR-alpha).

ERR1_HUMAN
θ value	1.6247e-33 (rank : 30)	NC score	0.950194 (rank : 19)
Query Neighborhood Hits	128	Target Neighborhood Hits	157	Shared Neighborhood Hits	94
SwissProt Accessions	P11474, Q14514	Gene names	ESRRA, ERR1, ESRL1, NR3B1
Domain Architecture
Description	Steroid hormone receptor ERR1 (Estrogen-related receptor, alpha) (ERR- alpha) (Estrogen receptor-like 1).

RXRG_MOUSE
θ value	4.72714e-33 (rank : 31)	NC score	0.943598 (rank : 20)
Query Neighborhood Hits	128	Target Neighborhood Hits	113	Shared Neighborhood Hits	94
SwissProt Accessions	P28705	Gene names	Rxrg, Nr2b3
Domain Architecture
Description	Retinoic acid receptor RXR-gamma (Retinoid X receptor gamma).

RXRG_HUMAN
θ value	6.17384e-33 (rank : 32)	NC score	0.943461 (rank : 21)
Query Neighborhood Hits	128	Target Neighborhood Hits	114	Shared Neighborhood Hits	94
SwissProt Accessions	P48443	Gene names	RXRG, NR2B3
Domain Architecture
Description	Retinoic acid receptor RXR-gamma (Retinoid X receptor gamma).

ESR1_HUMAN
θ value	1.0531e-32 (rank : 33)	NC score	0.939557 (rank : 27)
Query Neighborhood Hits	128	Target Neighborhood Hits	105	Shared Neighborhood Hits	94
SwissProt Accessions	P03372, Q13511, Q14276, Q9NU51, Q9UDZ7, Q9UIS7	Gene names	ESR1, ESR, NR3A1
Domain Architecture
Description	Estrogen receptor (ER) (Estradiol receptor) (ER-alpha).

ESR1_MOUSE
θ value	2.59387e-31 (rank : 34)	NC score	0.940338 (rank : 25)
Query Neighborhood Hits	128	Target Neighborhood Hits	104	Shared Neighborhood Hits	94
SwissProt Accessions	P19785, Q9JJT5, Q9QY51, Q9QY52	Gene names	Esr1, Esr, Estr, Estra, Nr3a1
Domain Architecture
Description	Estrogen receptor (ER) (Estradiol receptor) (ER-alpha).

EAR2_HUMAN
θ value	4.42448e-31 (rank : 35)	NC score	0.937282 (rank : 34)
Query Neighborhood Hits	128	Target Neighborhood Hits	106	Shared Neighborhood Hits	94
SwissProt Accessions	P10588, Q9BUE8	Gene names	NR2F6, EAR2, ERBAL2
Domain Architecture
Description	Orphan nuclear receptor EAR-2 (V-erbA-related protein EAR-2).

HNF4G_HUMAN
θ value	1.28732e-30 (rank : 36)	NC score	0.937232 (rank : 35)
Query Neighborhood Hits	128	Target Neighborhood Hits	100	Shared Neighborhood Hits	94
SwissProt Accessions	Q14541, Q9UH81, Q9UIS6	Gene names	HNF4G, NR2A2
Domain Architecture
Description	Hepatocyte nuclear factor 4-gamma (HNF-4-gamma).

PPARD_MOUSE
θ value	1.28732e-30 (rank : 37)	NC score	0.923673 (rank : 60)
Query Neighborhood Hits	128	Target Neighborhood Hits	103	Shared Neighborhood Hits	94
SwissProt Accessions	P35396, P37239	Gene names	Ppard, Nr1c2, Pparb
Domain Architecture
Description	Peroxisome proliferator-activated receptor delta (PPAR-delta) (PPAR- beta) (Nuclear hormone receptor 1) (NUC1).

RXRB_HUMAN
θ value	1.6813e-30 (rank : 38)	NC score	0.934555 (rank : 44)
Query Neighborhood Hits	128	Target Neighborhood Hits	280	Shared Neighborhood Hits	96
SwissProt Accessions	P28702, P28703	Gene names	RXRB, NR2B2
Domain Architecture
Description	Retinoic acid receptor RXR-beta (Retinoid X receptor beta).

RXRB_MOUSE
θ value	2.86786e-30 (rank : 39)	NC score	0.937113 (rank : 36)
Query Neighborhood Hits	128	Target Neighborhood Hits	230	Shared Neighborhood Hits	95
SwissProt Accessions	P28704, P33243	Gene names	Rxrb, Nr2b2
Domain Architecture
Description	Retinoic acid receptor RXR-beta (Retinoid X receptor beta) (MHC class I regulatory element-binding protein H-2RIIBP).

THA_HUMAN
θ value	1.08979e-29 (rank : 40)	NC score	0.932205 (rank : 50)
Query Neighborhood Hits	128	Target Neighborhood Hits	113	Shared Neighborhood Hits	94
SwissProt Accessions	P10827, P21205, Q8N6A1, Q96H73	Gene names	THRA, ERBA1, NR1A1, THRA1
Domain Architecture
Description	Thyroid hormone receptor alpha (C-erbA-alpha) (c-erbA-1) (EAR-7) (EAR7).

THA_MOUSE
θ value	1.08979e-29 (rank : 41)	NC score	0.932322 (rank : 49)
Query Neighborhood Hits	128	Target Neighborhood Hits	113	Shared Neighborhood Hits	94
SwissProt Accessions	P63058, P10685, P15827, P16416, P37241, Q63107, Q63195, Q63196, Q99146	Gene names	Thra, C-erba-alpha, Nr1a1
Domain Architecture	No domain graphic available
Description	Thyroid hormone receptor alpha (C-erbA-alpha) (c-erbA-1).

HNF4G_MOUSE
θ value	2.42779e-29 (rank : 42)	NC score	0.936230 (rank : 39)
Query Neighborhood Hits	128	Target Neighborhood Hits	101	Shared Neighborhood Hits	94
SwissProt Accessions	Q9WUU6	Gene names	Hnf4g, Nr2a2
Domain Architecture
Description	Hepatocyte nuclear factor 4-gamma (HNF-4-gamma).

NR2E3_MOUSE
θ value	5.40856e-29 (rank : 43)	NC score	0.933638 (rank : 45)
Query Neighborhood Hits	128	Target Neighborhood Hits	113	Shared Neighborhood Hits	94
SwissProt Accessions	Q9QXZ7	Gene names	Nr2e3, Pnr, Rnr
Domain Architecture
Description	Photoreceptor-specific nuclear receptor (Retina-specific nuclear receptor).

NR1H4_HUMAN
θ value	7.06379e-29 (rank : 44)	NC score	0.936853 (rank : 38)
Query Neighborhood Hits	128	Target Neighborhood Hits	112	Shared Neighborhood Hits	94
SwissProt Accessions	Q96RI1, Q8NFP5, Q8NFP6, Q92943	Gene names	NR1H4, BAR, FXR, HRR1, RIP14
Domain Architecture
Description	Bile acid receptor (Farnesoid X-activated receptor) (Farnesol receptor HRR-1) (Retinoid X receptor-interacting protein 14) (RXR-interacting protein 14).

NR2E3_HUMAN
θ value	7.06379e-29 (rank : 45)	NC score	0.932671 (rank : 48)
Query Neighborhood Hits	128	Target Neighborhood Hits	102	Shared Neighborhood Hits	94
SwissProt Accessions	Q9Y5X4, Q9UHM4	Gene names	NR2E3, PNR, RNR
Domain Architecture
Description	Photoreceptor-specific nuclear receptor (Retina-specific nuclear receptor).

THB1_MOUSE
θ value	1.2049e-28 (rank : 46)	NC score	0.925685 (rank : 56)
Query Neighborhood Hits	128	Target Neighborhood Hits	105	Shared Neighborhood Hits	94
SwissProt Accessions	P37242	Gene names	Thrb, C-erba-beta, Nr1a2
Domain Architecture
Description	Thyroid hormone receptor beta-1.

THB2_MOUSE
θ value	1.2049e-28 (rank : 47)	NC score	0.925775 (rank : 55)
Query Neighborhood Hits	128	Target Neighborhood Hits	106	Shared Neighborhood Hits	94
SwissProt Accessions	P37244	Gene names	Thrb, C-erba-beta, Nr1a2
Domain Architecture
Description	Thyroid hormone receptor beta-2.

THB2_HUMAN
θ value	2.05525e-28 (rank : 48)	NC score	0.926726 (rank : 53)
Query Neighborhood Hits	128	Target Neighborhood Hits	104	Shared Neighborhood Hits	94
SwissProt Accessions	P37243	Gene names	THRB, ERBA2, NR1A2, THR1
Domain Architecture	No domain graphic available
Description	Thyroid hormone receptor beta-2.

THB1_HUMAN
θ value	2.68423e-28 (rank : 49)	NC score	0.926525 (rank : 54)
Query Neighborhood Hits	128	Target Neighborhood Hits	106	Shared Neighborhood Hits	94
SwissProt Accessions	P10828, Q13986	Gene names	THRB, ERBA2, NR1A2, THR1
Domain Architecture
Description	Thyroid hormone receptor beta-1.

HNF4A_HUMAN
θ value	4.57862e-28 (rank : 50)	NC score	0.934833 (rank : 42)
Query Neighborhood Hits	128	Target Neighborhood Hits	105	Shared Neighborhood Hits	94
SwissProt Accessions	P41235, O00659, O00723, Q14540, Q92653, Q92654, Q92655, Q99864, Q9NQH0	Gene names	HNF4A, HNF4, NR2A1, TCF14
Domain Architecture
Description	Hepatocyte nuclear factor 4-alpha (HNF-4-alpha) (Transcription factor HNF-4) (Transcription factor 14).

NR1H4_MOUSE
θ value	4.57862e-28 (rank : 51)	NC score	0.936211 (rank : 40)
Query Neighborhood Hits	128	Target Neighborhood Hits	113	Shared Neighborhood Hits	94
SwissProt Accessions	Q60641, Q60642, Q60643	Gene names	Nr1h4, Bar, Fxr, Rip14
Domain Architecture
Description	Bile acid receptor (Farnesoid X-activated receptor) (Farnesol receptor HRR-1) (Retinoid X receptor-interacting protein 14) (RXR-interacting protein 14).

PPARD_HUMAN
θ value	1.02001e-27 (rank : 52)	NC score	0.923867 (rank : 58)
Query Neighborhood Hits	128	Target Neighborhood Hits	102	Shared Neighborhood Hits	94
SwissProt Accessions	Q03181, Q7Z5K0, Q9BUD4	Gene names	PPARD, NR1C2, PPARB
Domain Architecture
Description	Peroxisome proliferator-activated receptor delta (PPAR-delta) (PPAR- beta) (Nuclear hormone receptor 1) (NUC1) (NUCI).

HNF4A_MOUSE
θ value	2.96777e-27 (rank : 53)	NC score	0.934805 (rank : 43)
Query Neighborhood Hits	128	Target Neighborhood Hits	103	Shared Neighborhood Hits	94
SwissProt Accessions	P49698	Gene names	Hnf4a, Hnf-4, Hnf4, Nr2a1, Tcf14
Domain Architecture
Description	Hepatocyte nuclear factor 4-alpha (HNF-4-alpha) (Transcription factor HNF-4) (Transcription factor 14).

NR5A2_HUMAN
θ value	1.47289e-26 (rank : 54)	NC score	0.916308 (rank : 74)
Query Neighborhood Hits	128	Target Neighborhood Hits	112	Shared Neighborhood Hits	95
SwissProt Accessions	O00482, O95642	Gene names	NR5A2, B1F, CPF, FTF
Domain Architecture
Description	Orphan nuclear receptor NR5A2 (Alpha-1-fetoprotein transcription factor) (Hepatocytic transcription factor) (B1-binding factor) (hB1F) (CYP7A promoter-binding factor) (Liver receptor homolog 1) (LRH-1).

PPARG_HUMAN
θ value	3.28125e-26 (rank : 55)	NC score	0.922218 (rank : 65)
Query Neighborhood Hits	128	Target Neighborhood Hits	97	Shared Neighborhood Hits	94
SwissProt Accessions	P37231, O00684, O00710, O14515, Q15178, Q15179, Q15180, Q15832, Q86U60, Q96J12	Gene names	PPARG, NR1C3
Domain Architecture
Description	Peroxisome proliferator-activated receptor gamma (PPAR-gamma).

PPARG_MOUSE
θ value	3.28125e-26 (rank : 56)	NC score	0.922093 (rank : 67)
Query Neighborhood Hits	128	Target Neighborhood Hits	97	Shared Neighborhood Hits	94
SwissProt Accessions	P37238	Gene names	Pparg, Nr1c3
Domain Architecture
Description	Peroxisome proliferator-activated receptor gamma (PPAR-gamma).

NR1H2_MOUSE
θ value	1.24688e-25 (rank : 57)	NC score	0.933091 (rank : 46)
Query Neighborhood Hits	128	Target Neighborhood Hits	109	Shared Neighborhood Hits	95
SwissProt Accessions	Q60644	Gene names	Nr1h2, Lxrb, Rip15, Unr, Unr2
Domain Architecture
Description	Oxysterols receptor LXR-beta (Liver X receptor beta) (Nuclear orphan receptor LXR-beta) (Ubiquitously-expressed nuclear receptor) (Retinoid X receptor-interacting protein No.15).

NR2E1_MOUSE
θ value	1.62847e-25 (rank : 58)	NC score	0.932780 (rank : 47)
Query Neighborhood Hits	128	Target Neighborhood Hits	106	Shared Neighborhood Hits	94
SwissProt Accessions	Q64104	Gene names	Nr2e1, Tll, Tlx
Domain Architecture
Description	Orphan nuclear receptor NR2E1 (Nuclear receptor TLX) (Tailless homolog) (Tll) (mTll).

NR5A2_MOUSE
θ value	1.05554e-24 (rank : 59)	NC score	0.915950 (rank : 75)
Query Neighborhood Hits	128	Target Neighborhood Hits	107	Shared Neighborhood Hits	94
SwissProt Accessions	P45448	Gene names	Nr5a2, Lrh1
Domain Architecture
Description	Orphan nuclear receptor NR5A2 (Liver receptor homolog 1) (LRH-1).

PPARA_HUMAN
θ value	1.37858e-24 (rank : 60)	NC score	0.922101 (rank : 66)
Query Neighborhood Hits	128	Target Neighborhood Hits	100	Shared Neighborhood Hits	94
SwissProt Accessions	Q07869, Q16241, Q92486, Q92689, Q9Y3N1	Gene names	PPARA, NR1C1, PPAR
Domain Architecture
Description	Peroxisome proliferator-activated receptor alpha (PPAR-alpha).

PPARA_MOUSE
θ value	1.37858e-24 (rank : 61)	NC score	0.923136 (rank : 63)
Query Neighborhood Hits	128	Target Neighborhood Hits	99	Shared Neighborhood Hits	94
SwissProt Accessions	P23204	Gene names	Ppara, Nr1c1, Ppar
Domain Architecture
Description	Peroxisome proliferator-activated receptor alpha (PPAR-alpha).

STF1_HUMAN
θ value	4.01107e-24 (rank : 62)	NC score	0.923249 (rank : 62)
Query Neighborhood Hits	128	Target Neighborhood Hits	132	Shared Neighborhood Hits	95
SwissProt Accessions	Q13285, O15196	Gene names	NR5A1, AD4BP, FTZF1, SF1
Domain Architecture
Description	Steroidogenic factor 1 (STF-1) (SF-1) (Adrenal 4-binding protein) (Steroid hormone receptor Ad4BP) (Fushi tarazu factor homolog 1).

STF1_MOUSE
θ value	4.01107e-24 (rank : 63)	NC score	0.922409 (rank : 64)
Query Neighborhood Hits	128	Target Neighborhood Hits	137	Shared Neighborhood Hits	94
SwissProt Accessions	P33242	Gene names	Nr5a1, Ftzf1
Domain Architecture
Description	Steroidogenic factor 1 (STF-1) (SF-1) (Adrenal 4-binding protein) (Steroid hormone receptor Ad4BP) (Fushi tarazu factor homolog 1) (Embryonal LTR-binding protein) (ELP) (Embryonal long terminal repeat- binding protein) (Steroid hydroxylase positive regulator).

PXR_HUMAN
θ value	6.84181e-24 (rank : 64)	NC score	0.918696 (rank : 71)
Query Neighborhood Hits	128	Target Neighborhood Hits	107	Shared Neighborhood Hits	94
SwissProt Accessions	O75469, Q96AC7, Q9UJ22, Q9UJ23, Q9UJ24, Q9UJ25, Q9UJ26, Q9UJ27	Gene names	NR1I2, PXR
Domain Architecture
Description	Orphan nuclear receptor PXR (Pregnane X receptor) (Orphan nuclear receptor PAR1) (Steroid and xenobiotic receptor) (SXR).

NR1I3_MOUSE
θ value	1.5242e-23 (rank : 65)	NC score	0.935119 (rank : 41)
Query Neighborhood Hits	128	Target Neighborhood Hits	103	Shared Neighborhood Hits	94
SwissProt Accessions	O35627, O35628	Gene names	Nr1i3, Car
Domain Architecture
Description	Orphan nuclear receptor NR1I3 (Constitutive androstane receptor) (CAR) (Orphan nuclear receptor MB67).

NR2E1_HUMAN
θ value	1.5242e-23 (rank : 66)	NC score	0.931606 (rank : 51)
Query Neighborhood Hits	128	Target Neighborhood Hits	103	Shared Neighborhood Hits	94
SwissProt Accessions	Q9Y466	Gene names	NR2E1, TLX
Domain Architecture
Description	Orphan nuclear receptor NR2E1 (Nuclear receptor TLX) (Tailless homolog) (Tll) (hTll).

GCR_HUMAN
θ value	1.99067e-23 (rank : 67)	NC score	0.886887 (rank : 87)
Query Neighborhood Hits	128	Target Neighborhood Hits	113	Shared Neighborhood Hits	94
SwissProt Accessions	P04150, P04151, Q53EP5, Q6N0A4	Gene names	NR3C1, GRL
Domain Architecture
Description	Glucocorticoid receptor (GR).

GCR_MOUSE
θ value	1.99067e-23 (rank : 68)	NC score	0.882158 (rank : 88)
Query Neighborhood Hits	128	Target Neighborhood Hits	117	Shared Neighborhood Hits	94
SwissProt Accessions	P06537, Q61628, Q61629	Gene names	Nr3c1, Grl, Grl1
Domain Architecture
Description	Glucocorticoid receptor (GR).

NR1H2_HUMAN
θ value	5.79196e-23 (rank : 69)	NC score	0.921782 (rank : 68)
Query Neighborhood Hits	128	Target Neighborhood Hits	114	Shared Neighborhood Hits	95
SwissProt Accessions	P55055, Q12970	Gene names	NR1H2, LXRB, NER, UNR
Domain Architecture
Description	Oxysterols receptor LXR-beta (Liver X receptor beta) (Nuclear orphan receptor LXR-beta) (Ubiquitously-expressed nuclear receptor) (Nuclear receptor NER).

PXR_MOUSE
θ value	9.87957e-23 (rank : 70)	NC score	0.917115 (rank : 73)
Query Neighborhood Hits	128	Target Neighborhood Hits	107	Shared Neighborhood Hits	94
SwissProt Accessions	O54915	Gene names	Nr1i2, Pxr
Domain Architecture
Description	Orphan nuclear receptor PXR (Pregnane X receptor).

NR1D2_HUMAN
θ value	1.6852e-22 (rank : 71)	NC score	0.918164 (rank : 72)
Query Neighborhood Hits	128	Target Neighborhood Hits	115	Shared Neighborhood Hits	94
SwissProt Accessions	Q14995, O00402, Q86XD4	Gene names	NR1D2
Domain Architecture
Description	Orphan nuclear receptor NR1D2 (Rev-erb-beta) (EAR-1R) (Orphan nuclear hormone receptor BD73).

NR1D2_MOUSE
θ value	2.20094e-22 (rank : 72)	NC score	0.915747 (rank : 77)
Query Neighborhood Hits	128	Target Neighborhood Hits	109	Shared Neighborhood Hits	94
SwissProt Accessions	Q60674, Q60646	Gene names	Nr1d2
Domain Architecture
Description	Orphan nuclear receptor NR1D2 (Rev-erb-beta) (Orphan nuclear receptor RVR).

TR4_HUMAN
θ value	2.20094e-22 (rank : 73)	NC score	0.900744 (rank : 85)
Query Neighborhood Hits	128	Target Neighborhood Hits	117	Shared Neighborhood Hits	94
SwissProt Accessions	P49116, P55092	Gene names	NR2C2, TAK1, TR4
Domain Architecture
Description	Orphan nuclear receptor TR4 (Orphan nuclear receptor TAK1).

TR2_MOUSE
θ value	4.9032e-22 (rank : 74)	NC score	0.905599 (rank : 78)
Query Neighborhood Hits	128	Target Neighborhood Hits	100	Shared Neighborhood Hits	94
SwissProt Accessions	Q505F1, P97763, Q3UIJ7, Q4U1Z4, Q60927, Q62152, Q8VIJ3	Gene names	Nr2c1, Tr2, Tr2-11
Domain Architecture	No domain graphic available
Description	Orphan nuclear receptor TR2 (Testicular receptor 2) (mTR2).

TR2_HUMAN
θ value	6.40375e-22 (rank : 75)	NC score	0.920103 (rank : 69)
Query Neighborhood Hits	128	Target Neighborhood Hits	110	Shared Neighborhood Hits	95
SwissProt Accessions	P13056	Gene names	NR2C1, TR2
Domain Architecture
Description	Orphan nuclear receptor TR2 (Testicular receptor 2).

TR4_MOUSE
θ value	8.36355e-22 (rank : 76)	NC score	0.899901 (rank : 86)
Query Neighborhood Hits	128	Target Neighborhood Hits	115	Shared Neighborhood Hits	94
SwissProt Accessions	P49117, P55093	Gene names	Nr2c2, Mtr2r1, Tak1, Tr4
Domain Architecture
Description	Orphan nuclear receptor TR4 (Orphan nuclear receptor TAK1).

NR1D1_HUMAN
θ value	2.43343e-21 (rank : 77)	NC score	0.923746 (rank : 59)
Query Neighborhood Hits	128	Target Neighborhood Hits	140	Shared Neighborhood Hits	95
SwissProt Accessions	P20393, Q15304	Gene names	NR1D1, EAR1, HREV, THRAL
Domain Architecture
Description	Orphan nuclear receptor NR1D1 (V-erbA-related protein EAR-1) (Rev- erbA-alpha).

RORA_HUMAN
θ value	4.15078e-21 (rank : 78)	NC score	0.902521 (rank : 80)
Query Neighborhood Hits	128	Target Neighborhood Hits	105	Shared Neighborhood Hits	94
SwissProt Accessions	P35398, P35397, P35399, P45445, Q96H83	Gene names	RORA, NR1F1, RZRA
Domain Architecture
Description	Nuclear receptor ROR-alpha (Nuclear receptor RZR-alpha).

RORA_MOUSE
θ value	4.15078e-21 (rank : 79)	NC score	0.901924 (rank : 83)
Query Neighborhood Hits	128	Target Neighborhood Hits	105	Shared Neighborhood Hits	94
SwissProt Accessions	P51448, P70283, P97741, P97773, Q923G1	Gene names	Rora, Nr1f1, Rzra
Domain Architecture
Description	Nuclear receptor ROR-alpha (Nuclear receptor RZR-alpha).

RORG_HUMAN
θ value	7.0802e-21 (rank : 80)	NC score	0.901175 (rank : 84)
Query Neighborhood Hits	128	Target Neighborhood Hits	119	Shared Neighborhood Hits	94
SwissProt Accessions	P51449, Q8N5V7, Q8NCY8	Gene names	RORC, NR1F3, RORG, RZRG
Domain Architecture
Description	Nuclear receptor ROR-gamma (Nuclear receptor RZR-gamma).

RORG_MOUSE
θ value	7.0802e-21 (rank : 81)	NC score	0.904962 (rank : 79)
Query Neighborhood Hits	128	Target Neighborhood Hits	107	Shared Neighborhood Hits	94
SwissProt Accessions	P51450, Q61027, Q91YT5, Q9QXD9, Q9R177	Gene names	Rorc, Nr1f3, Rorg, Thor
Domain Architecture
Description	Nuclear receptor ROR-gamma (Nuclear receptor RZR-gamma) (Thymus orphan receptor) (TOR).

VDR_MOUSE
θ value	7.0802e-21 (rank : 82)	NC score	0.919247 (rank : 70)
Query Neighborhood Hits	128	Target Neighborhood Hits	103	Shared Neighborhood Hits	94
SwissProt Accessions	P48281	Gene names	Vdr, Nr1i1
Domain Architecture
Description	Vitamin D3 receptor (VDR) (1,25-dihydroxyvitamin D3 receptor).

ANDR_MOUSE
θ value	9.24701e-21 (rank : 83)	NC score	0.880789 (rank : 89)
Query Neighborhood Hits	128	Target Neighborhood Hits	133	Shared Neighborhood Hits	94
SwissProt Accessions	P19091	Gene names	Ar, Nr3c4
Domain Architecture
Description	Androgen receptor (Dihydrotestosterone receptor).

RORB_HUMAN
θ value	1.2077e-20 (rank : 84)	NC score	0.902318 (rank : 82)
Query Neighborhood Hits	128	Target Neighborhood Hits	99	Shared Neighborhood Hits	94
SwissProt Accessions	Q92753, Q8WX73	Gene names	RORB, NR1F2, RZRB
Domain Architecture
Description	Nuclear receptor ROR-beta (Nuclear receptor RZR-beta).

RORB_MOUSE
θ value	1.2077e-20 (rank : 85)	NC score	0.902467 (rank : 81)
Query Neighborhood Hits	128	Target Neighborhood Hits	99	Shared Neighborhood Hits	94
SwissProt Accessions	Q8R1B8	Gene names	Rorb, Nr1f2
Domain Architecture
Description	Nuclear receptor ROR-beta (Nuclear receptor RZR-beta).

NR6A1_HUMAN
θ value	2.06002e-20 (rank : 86)	NC score	0.924182 (rank : 57)
Query Neighborhood Hits	128	Target Neighborhood Hits	108	Shared Neighborhood Hits	94
SwissProt Accessions	Q15406, O00551, O00603, Q8NHQ0, Q92898, Q99802	Gene names	NR6A1, GCNF
Domain Architecture
Description	Orphan nuclear receptor NR6A1 (Germ cell nuclear factor) (GCNF) (Retinoid receptor-related testis-specific receptor) (RTR).

NR6A1_MOUSE
θ value	2.06002e-20 (rank : 87)	NC score	0.923622 (rank : 61)
Query Neighborhood Hits	128	Target Neighborhood Hits	110	Shared Neighborhood Hits	94
SwissProt Accessions	Q64249	Gene names	Nr6a1, Gcnf
Domain Architecture
Description	Orphan nuclear receptor NR6A1 (Germ cell nuclear factor) (GCNF) (Retinoid receptor-related testis-specific receptor) (RTR).

PRGR_MOUSE
θ value	2.06002e-20 (rank : 88)	NC score	0.867849 (rank : 94)
Query Neighborhood Hits	128	Target Neighborhood Hits	286	Shared Neighborhood Hits	96
SwissProt Accessions	Q00175	Gene names	Pgr, Nr3c3, Pr
Domain Architecture
Description	Progesterone receptor (PR).

PRGR_HUMAN
θ value	1.02238e-19 (rank : 89)	NC score	0.872771 (rank : 93)
Query Neighborhood Hits	128	Target Neighborhood Hits	163	Shared Neighborhood Hits	96
SwissProt Accessions	P06401, Q9UPF7	Gene names	PGR, NR3C3
Domain Architecture
Description	Progesterone receptor (PR).

ANDR_HUMAN
θ value	1.33526e-19 (rank : 90)	NC score	0.878530 (rank : 90)
Query Neighborhood Hits	128	Target Neighborhood Hits	126	Shared Neighborhood Hits	94
SwissProt Accessions	P10275	Gene names	AR, DHTR, NR3C4
Domain Architecture
Description	Androgen receptor (Dihydrotestosterone receptor).

VDR_HUMAN
θ value	2.5182e-18 (rank : 91)	NC score	0.915859 (rank : 76)
Query Neighborhood Hits	128	Target Neighborhood Hits	112	Shared Neighborhood Hits	94
SwissProt Accessions	P11473	Gene names	VDR, NR1I1
Domain Architecture
Description	Vitamin D3 receptor (VDR) (1,25-dihydroxyvitamin D3 receptor).

MCR_HUMAN
θ value	7.32683e-18 (rank : 92)	NC score	0.877699 (rank : 91)
Query Neighborhood Hits	128	Target Neighborhood Hits	149	Shared Neighborhood Hits	95
SwissProt Accessions	P08235, Q96KQ8, Q96KQ9	Gene names	NR3C2, MCR, MLR
Domain Architecture
Description	Mineralocorticoid receptor (MR).

NR1I3_HUMAN
θ value	2.35696e-16 (rank : 93)	NC score	0.929401 (rank : 52)
Query Neighborhood Hits	128	Target Neighborhood Hits	107	Shared Neighborhood Hits	94
SwissProt Accessions	Q14994	Gene names	NR1I3, CAR
Domain Architecture
Description	Orphan nuclear receptor NR1I3 (Constitutive androstane receptor) (CAR) (Constitutive activator of retinoid response) (Constitutive active response) (Orphan nuclear receptor MB67).

MCR_MOUSE
θ value	1.99529e-15 (rank : 94)	NC score	0.873678 (rank : 92)
Query Neighborhood Hits	128	Target Neighborhood Hits	162	Shared Neighborhood Hits	94
SwissProt Accessions	Q8VII8, Q8VII9	Gene names	Nr3c2, Mlr
Domain Architecture	No domain graphic available
Description	Mineralocorticoid receptor (MR).

TSC1_HUMAN
θ value	0.0431538 (rank : 95)	NC score	0.013822 (rank : 103)
Query Neighborhood Hits	128	Target Neighborhood Hits	765	Shared Neighborhood Hits	9
SwissProt Accessions	Q92574	Gene names	TSC1, KIAA0243, TSC
Domain Architecture
Description	Hamartin (Tuberous sclerosis 1 protein).

SC24C_HUMAN
θ value	0.163984 (rank : 96)	NC score	0.024891 (rank : 99)
Query Neighborhood Hits	128	Target Neighborhood Hits	662	Shared Neighborhood Hits	16
SwissProt Accessions	P53992, Q8WV25	Gene names	SEC24C, KIAA0079
Domain Architecture
Description	Protein transport protein Sec24C (SEC24-related protein C).

TROAP_HUMAN
θ value	0.365318 (rank : 97)	NC score	0.023781 (rank : 100)
Query Neighborhood Hits	128	Target Neighborhood Hits	258	Shared Neighborhood Hits	6
SwissProt Accessions	Q12815	Gene names	TROAP
Domain Architecture	No domain graphic available
Description	Trophinin-associated protein (Tastin) (Trophinin-assisting protein).

GAK_MOUSE
θ value	0.47712 (rank : 98)	NC score	-0.005380 (rank : 130)
Query Neighborhood Hits	128	Target Neighborhood Hits	964	Shared Neighborhood Hits	4
SwissProt Accessions	Q99KY4, Q6P1I8, Q6P9S5, Q8BM74, Q8K0Q4	Gene names	Gak
Domain Architecture	No domain graphic available
Description	Cyclin G-associated kinase (EC 2.7.11.1).

SMAL1_HUMAN
θ value	0.47712 (rank : 99)	NC score	0.007178 (rank : 108)
Query Neighborhood Hits	128	Target Neighborhood Hits	174	Shared Neighborhood Hits	4
SwissProt Accessions	Q9NZC9, Q96AY1, Q9NXQ5, Q9UFH3, Q9UI93	Gene names	SMARCAL1, HARP
Domain Architecture	No domain graphic available
Description	SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A-like protein 1 (EC 3.6.1.-) (Sucrose nonfermenting protein 2-like 1) (HepA-related protein) (hHARP).

MUC1_HUMAN
θ value	0.62314 (rank : 100)	NC score	0.001563 (rank : 121)
Query Neighborhood Hits	128	Target Neighborhood Hits	975	Shared Neighborhood Hits	15
SwissProt Accessions	P15941, P13931, P15942, P17626, Q14128, Q14876, Q16437, Q16442, Q16615, Q9BXA4, Q9UE75, Q9UE76, Q9UQL1, Q9Y4J2	Gene names	MUC1
Domain Architecture
Description	Mucin-1 precursor (MUC-1) (Polymorphic epithelial mucin) (PEM) (PEMT) (Episialin) (Tumor-associated mucin) (Carcinoma-associated mucin) (Tumor-associated epithelial membrane antigen) (EMA) (H23AG) (Peanut- reactive urinary mucin) (PUM) (Breast carcinoma-associated antigen DF3) (CD227 antigen).

PGBM_MOUSE
θ value	0.813845 (rank : 101)	NC score	-0.003150 (rank : 129)
Query Neighborhood Hits	128	Target Neighborhood Hits	1073	Shared Neighborhood Hits	7
SwissProt Accessions	Q05793	Gene names	Hspg2
Domain Architecture
Description	Basement membrane-specific heparan sulfate proteoglycan core protein precursor (HSPG) (Perlecan) (PLC).

PHF12_HUMAN
θ value	0.813845 (rank : 102)	NC score	0.013981 (rank : 102)
Query Neighborhood Hits	128	Target Neighborhood Hits	174	Shared Neighborhood Hits	5
SwissProt Accessions	Q96QT6, Q6ZML2, Q9BV34, Q9H7U9, Q9P205	Gene names	PHF12, KIAA1523
Domain Architecture	No domain graphic available
Description	PHD finger protein 12 (PHD factor 1) (Pf1).

CO002_HUMAN
θ value	1.06291 (rank : 103)	NC score	0.014906 (rank : 101)
Query Neighborhood Hits	128	Target Neighborhood Hits	387	Shared Neighborhood Hits	8
SwissProt Accessions	Q9NZP6	Gene names	C15orf2
Domain Architecture	No domain graphic available
Description	Protein C15orf2.

SNX19_HUMAN
θ value	1.06291 (rank : 104)	NC score	0.013453 (rank : 105)
Query Neighborhood Hits	128	Target Neighborhood Hits	123	Shared Neighborhood Hits	2
SwissProt Accessions	Q92543	Gene names	SNX19, KIAA0254
Domain Architecture
Description	Sorting nexin-19.

ZN516_HUMAN
θ value	1.81305 (rank : 105)	NC score	-0.006168 (rank : 131)
Query Neighborhood Hits	128	Target Neighborhood Hits	854	Shared Neighborhood Hits	4
SwissProt Accessions	Q92618	Gene names	ZNF516, KIAA0222
Domain Architecture	No domain graphic available
Description	Zinc finger protein 516.

PHF12_MOUSE
θ value	2.36792 (rank : 106)	NC score	0.013691 (rank : 104)
Query Neighborhood Hits	128	Target Neighborhood Hits	172	Shared Neighborhood Hits	5
SwissProt Accessions	Q5SPL2, Q5SPL3, Q6ZPN8, Q80W50	Gene names	Phf12, Kiaa1523
Domain Architecture	No domain graphic available
Description	PHD finger protein 12 (PHD factor 1) (Pf1).

ZIMP7_HUMAN
θ value	2.36792 (rank : 107)	NC score	0.004683 (rank : 114)
Query Neighborhood Hits	128	Target Neighborhood Hits	290	Shared Neighborhood Hits	6
SwissProt Accessions	Q8NF64, O94790, Q659A8, Q6JKL5, Q8WTX8, Q96Q01, Q9BQH7	Gene names	ZIMP7, KIAA1886
Domain Architecture	No domain graphic available
Description	PIAS-like protein Zimp7.

FHOD1_MOUSE
θ value	3.0926 (rank : 108)	NC score	0.004999 (rank : 112)
Query Neighborhood Hits	128	Target Neighborhood Hits	217	Shared Neighborhood Hits	5
SwissProt Accessions	Q6P9Q4, Q8BMK2	Gene names	Fhod1, Fhos1
Domain Architecture	No domain graphic available
Description	FH1/FH2 domain-containing protein (Formin homolog overexpressed in spleen) (FHOS) (Formin homology 2 domain-containing protein 1).

K0423_MOUSE
θ value	3.0926 (rank : 109)	NC score	0.012436 (rank : 106)
Query Neighborhood Hits	128	Target Neighborhood Hits	115	Shared Neighborhood Hits	3
SwissProt Accessions	Q6A070	Gene names	Kiaa0423
Domain Architecture	No domain graphic available
Description	Protein KIAA0423.

ENAH_MOUSE
θ value	4.03905 (rank : 110)	NC score	0.005448 (rank : 110)
Query Neighborhood Hits	128	Target Neighborhood Hits	919	Shared Neighborhood Hits	16
SwissProt Accessions	Q03173, P70430, P70431, P70432, P70433, Q5D053	Gene names	Enah, Mena, Ndpp1
Domain Architecture
Description	Protein enabled homolog (NPC-derived proline-rich protein 1) (NDPP-1).

PTN13_MOUSE
θ value	4.03905 (rank : 111)	NC score	-0.002610 (rank : 127)
Query Neighborhood Hits	128	Target Neighborhood Hits	426	Shared Neighborhood Hits	4
SwissProt Accessions	Q64512, Q61494, Q62135, Q64499	Gene names	Ptpn13, Ptp14
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 13 (EC 3.1.3.48) (Protein tyrosine phosphatase PTP-BL) (Protein-tyrosine phosphatase RIP) (protein tyrosine phosphatase DPZPTP) (PTP36).

ZDHC8_HUMAN
θ value	4.03905 (rank : 112)	NC score	0.003132 (rank : 120)
Query Neighborhood Hits	128	Target Neighborhood Hits	234	Shared Neighborhood Hits	8
SwissProt Accessions	Q9ULC8, Q6ICL1, Q6ZNF5, Q7Z6L9	Gene names	ZDHHC8, KIAA1292, ZDHHCL1, ZNF378
Domain Architecture
Description	Probable palmitoyltransferase ZDHHC8 (EC 2.3.1.-) (Zinc finger DHHC domain-containing protein 8) (DHHC-8) (Zinc finger protein 378).

BCAR1_HUMAN
θ value	5.27518 (rank : 113)	NC score	0.001176 (rank : 123)
Query Neighborhood Hits	128	Target Neighborhood Hits	554	Shared Neighborhood Hits	6
SwissProt Accessions	P56945	Gene names	BCAR1, CAS, CRKAS
Domain Architecture
Description	Breast cancer anti-estrogen resistance protein 1 (CRK-associated substrate) (p130cas).

CI079_HUMAN
θ value	5.27518 (rank : 114)	NC score	0.007154 (rank : 109)
Query Neighborhood Hits	128	Target Neighborhood Hits	288	Shared Neighborhood Hits	7
SwissProt Accessions	Q6ZUB1, Q5SQC9, Q8NA41, Q8ND27	Gene names	C9orf79
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C9orf79.

DC1L2_MOUSE
θ value	5.27518 (rank : 115)	NC score	0.003467 (rank : 118)
Query Neighborhood Hits	128	Target Neighborhood Hits	173	Shared Neighborhood Hits	3
SwissProt Accessions	Q6PDL0	Gene names	Dync1li2, Dncli2, Dnclic2
Domain Architecture	No domain graphic available
Description	Cytoplasmic dynein 1 light intermediate chain 2 (Dynein light intermediate chain 2, cytosolic).

DLGP3_MOUSE
θ value	5.27518 (rank : 116)	NC score	0.003674 (rank : 117)
Query Neighborhood Hits	128	Target Neighborhood Hits	56	Shared Neighborhood Hits	2
SwissProt Accessions	Q6PFD5, Q6PDX0, Q6XBF2	Gene names	Dlgap3, Dap3
Domain Architecture	No domain graphic available
Description	Disks large-associated protein 3 (DAP-3) (SAP90/PSD-95-associated protein 3) (SAPAP3) (PSD-95/SAP90-binding protein 3).

HRBL_MOUSE
θ value	5.27518 (rank : 117)	NC score	0.003950 (rank : 116)
Query Neighborhood Hits	128	Target Neighborhood Hits	269	Shared Neighborhood Hits	8
SwissProt Accessions	Q80WC7, Q8BKS5, Q99J67	Gene names	Hrbl, Rabr
Domain Architecture
Description	HIV-1 Rev-binding protein-like protein (Rev/Rex activation domain- binding protein related) (RAB-R).

CBX2_MOUSE
θ value	6.88961 (rank : 118)	NC score	0.005169 (rank : 111)
Query Neighborhood Hits	128	Target Neighborhood Hits	119	Shared Neighborhood Hits	3
SwissProt Accessions	P30658, O35731, Q8CIA0	Gene names	Cbx2, M33
Domain Architecture
Description	Chromobox protein homolog 2 (Modifier 3 protein) (M33).

CRIP3_HUMAN
θ value	6.88961 (rank : 119)	NC score	0.000915 (rank : 124)
Query Neighborhood Hits	128	Target Neighborhood Hits	104	Shared Neighborhood Hits	2
SwissProt Accessions	Q6Q6R5, Q5T043, Q6Q6R4, Q6Q6R6, Q6Q6R7	Gene names	CRIP3
Domain Architecture	No domain graphic available
Description	Cysteine-rich protein 3 (CRP3) (Chromosome 6 LIM-only protein) (h6LIMo).

FOXO4_MOUSE
θ value	6.88961 (rank : 120)	NC score	-0.000333 (rank : 126)
Query Neighborhood Hits	128	Target Neighborhood Hits	168	Shared Neighborhood Hits	2
SwissProt Accessions	Q9WVH3	Gene names	Mllt7, Afx, Afx1, Fkhr3, Foxo4
Domain Architecture
Description	Fork head domain transcription factor AFX1 (Afxh) (Forkhead box protein O4).

SRBP1_HUMAN
θ value	6.88961 (rank : 121)	NC score	0.004723 (rank : 113)
Query Neighborhood Hits	128	Target Neighborhood Hits	225	Shared Neighborhood Hits	5
SwissProt Accessions	P36956, Q16062	Gene names	SREBF1, SREBP1
Domain Architecture
Description	Sterol regulatory element-binding protein 1 (SREBP-1) (Sterol regulatory element-binding transcription factor 1).

SRRM2_MOUSE
θ value	6.88961 (rank : 122)	NC score	-0.002787 (rank : 128)
Query Neighborhood Hits	128	Target Neighborhood Hits	1470	Shared Neighborhood Hits	19
SwissProt Accessions	Q8BTI8, Q3TBY5, Q569P9, Q80U37, Q8K383	Gene names	Srrm2, Kiaa0324
Domain Architecture	No domain graphic available
Description	Serine/arginine repetitive matrix protein 2.

SYNG_HUMAN
θ value	6.88961 (rank : 123)	NC score	0.003980 (rank : 115)
Query Neighborhood Hits	128	Target Neighborhood Hits	160	Shared Neighborhood Hits	4
SwissProt Accessions	Q9UMZ2, Q6ZT17	Gene names	AP1GBP1, SYNG
Domain Architecture	No domain graphic available
Description	AP1 subunit gamma-binding protein 1 (Gamma-synergin).

CDKL5_HUMAN
θ value	8.99809 (rank : 124)	NC score	-0.008925 (rank : 132)
Query Neighborhood Hits	128	Target Neighborhood Hits	967	Shared Neighborhood Hits	4
SwissProt Accessions	O76039, Q14198, Q5H985, Q9UJL6	Gene names	CDKL5, STK9
Domain Architecture
Description	Cyclin-dependent kinase-like 5 (EC 2.7.11.22) (Serine/threonine- protein kinase 9).

EVC_MOUSE
θ value	8.99809 (rank : 125)	NC score	0.007654 (rank : 107)
Query Neighborhood Hits	128	Target Neighborhood Hits	80	Shared Neighborhood Hits	3
SwissProt Accessions	P57680	Gene names	Evc
Domain Architecture	No domain graphic available
Description	Ellis-van Creveld syndrome protein homolog.

IRF4_MOUSE
θ value	8.99809 (rank : 126)	NC score	0.001317 (rank : 122)
Query Neighborhood Hits	128	Target Neighborhood Hits	27	Shared Neighborhood Hits	2
SwissProt Accessions	Q64287, Q60802	Gene names	Irf4, Spip
Domain Architecture
Description	Interferon regulatory factor 4 (IRF-4) (Lymphocyte-specific interferon regulatory factor) (LSIRF) (NF-EM5) (PU.1 interaction partner) (Transcriptional activator PIP).

MUC5B_HUMAN
θ value	8.99809 (rank : 127)	NC score	-0.000282 (rank : 125)
Query Neighborhood Hits	128	Target Neighborhood Hits	1020	Shared Neighborhood Hits	12
SwissProt Accessions	Q9HC84, O00447, O00573, O14985, O15494, O95291, O95451, Q14881, Q99552, Q9UE28	Gene names	MUC5B, MUC5
Domain Architecture
Description	Mucin-5B precursor (Mucin-5 subtype B, tracheobronchial) (High molecular weight salivary mucin MG1) (Sublingual gland mucin).

SPON2_HUMAN
θ value	8.99809 (rank : 128)	NC score	0.003197 (rank : 119)
Query Neighborhood Hits	128	Target Neighborhood Hits	53	Shared Neighborhood Hits	2
SwissProt Accessions	Q9BUD6, Q9ULW1	Gene names	SPON2, DIL1
Domain Architecture	No domain graphic available
Description	Spondin-2 precursor (Mindin) (Differentially expressed in cancerous and non-cancerous lung cells 1) (DIL-1).

DAX1_HUMAN
θ value	θ > 10 (rank : 129)	NC score	0.399291 (rank : 98)
Query Neighborhood Hits	128	Target Neighborhood Hits	65	Shared Neighborhood Hits	55
SwissProt Accessions	P51843, Q96F69	Gene names	NR0B1, AHC, DAX1
Domain Architecture
Description	Nuclear receptor 0B1 (Nuclear receptor DAX-1) (DSS-AHC critical region on the X chromosome protein 1).

DAX1_MOUSE
θ value	θ > 10 (rank : 130)	NC score	0.430791 (rank : 96)
Query Neighborhood Hits	128	Target Neighborhood Hits	70	Shared Neighborhood Hits	56
SwissProt Accessions	Q61066, O09068, O09147	Gene names	Nr0b1, Ahch, Dax1
Domain Architecture
Description	Nuclear receptor 0B1 (Nuclear receptor DAX-1).

SHP_HUMAN
θ value	θ > 10 (rank : 131)	NC score	0.439276 (rank : 95)
Query Neighborhood Hits	128	Target Neighborhood Hits	57	Shared Neighborhood Hits	52
SwissProt Accessions	Q15466, Q5QP36	Gene names	NR0B2, SHP
Domain Architecture
Description	Nuclear receptor 0B2 (Orphan nuclear receptor SHP) (Small heterodimer partner).

SHP_MOUSE
θ value	θ > 10 (rank : 132)	NC score	0.429365 (rank : 97)
Query Neighborhood Hits	128	Target Neighborhood Hits	53	Shared Neighborhood Hits	49
SwissProt Accessions	Q62227, Q53Z53	Gene names	Nr0b2, Shp
Domain Architecture
Description	Nuclear receptor 0B2 (Orphan nuclear receptor SHP) (Small heterodimer partner).

Hits sorted by NC score

NR4A1_MOUSE
NC score	0.999962 (rank : 1)	θ value	0 (rank : 2)
Query Neighborhood Hits	128	Target Neighborhood Hits	128	Shared Neighborhood Hits	128
SwissProt Accessions	P12813	Gene names	Nr4a1, Gfrp, Hmr, N10, Nur77
Domain Architecture
Description	Orphan nuclear receptor NR4A1 (Orphan nuclear receptor HMR) (Nuclear hormone receptor NUR/77) (N10 nuclear protein).

NR4A1_HUMAN
NC score	0.997808 (rank : 2)	θ value	0 (rank : 1)
Query Neighborhood Hits	128	Target Neighborhood Hits	133	Shared Neighborhood Hits	105
SwissProt Accessions	P22736	Gene names	NR4A1, GFRP1, HMR, NAK1
Domain Architecture
Description	Orphan nuclear receptor NR4A1 (Orphan nuclear receptor HMR) (Early response protein NAK1) (TR3 orphan receptor) (ST-59).

NR4A2_HUMAN
NC score	0.993561 (rank : 3)	θ value	1.37464e-149 (rank : 3)
Query Neighborhood Hits	128	Target Neighborhood Hits	120	Shared Neighborhood Hits	94
SwissProt Accessions	P43354, Q16311	Gene names	NR4A2, NOT, NURR1, TINUR
Domain Architecture
Description	Orphan nuclear receptor NR4A2 (Orphan nuclear receptor NURR1) (Immediate-early response protein NOT) (Transcriptionally-inducible nuclear receptor).

NR4A2_MOUSE
NC score	0.993557 (rank : 4)	θ value	1.79534e-149 (rank : 4)
Query Neighborhood Hits	128	Target Neighborhood Hits	121	Shared Neighborhood Hits	94
SwissProt Accessions	Q06219, O08690	Gene names	Nr4a2, Nurr1
Domain Architecture
Description	Orphan nuclear receptor NR4A2 (Orphan nuclear receptor NURR1) (NUR- related factor 1).

NR4A3_HUMAN
NC score	0.990817 (rank : 5)	θ value	1.58745e-113 (rank : 6)
Query Neighborhood Hits	128	Target Neighborhood Hits	131	Shared Neighborhood Hits	94
SwissProt Accessions	Q92570, Q12935, Q14979, Q16420, Q4VXA9, Q9UEK2, Q9UEK3	Gene names	NR4A3, CHN, CSMF, MINOR, NOR1, TEC
Domain Architecture
Description	Orphan nuclear receptor NR4A3 (Nuclear hormone receptor NOR-1) (Neuron-derived orphan receptor 1) (Mitogen-induced nuclear orphan receptor).

NR4A3_MOUSE
NC score	0.990755 (rank : 6)	θ value	1.21547e-113 (rank : 5)
Query Neighborhood Hits	128	Target Neighborhood Hits	127	Shared Neighborhood Hits	95
SwissProt Accessions	Q9QZB6, Q9QZB5	Gene names	Nr4a3, Tec
Domain Architecture
Description	Orphan nuclear receptor NR4A3 (Orphan nuclear receptor TEC) (Translocated in extraskeletal chondrosarcoma).

RARB_MOUSE
NC score	0.956090 (rank : 7)	θ value	1.28137e-46 (rank : 9)
Query Neighborhood Hits	128	Target Neighborhood Hits	109	Shared Neighborhood Hits	96
SwissProt Accessions	P22605, P11417, P22604	Gene names	Rarb, Nr1b2
Domain Architecture
Description	Retinoic acid receptor beta (RAR-beta).

RARG2_HUMAN
NC score	0.955981 (rank : 8)	θ value	1.08474e-45 (rank : 12)
Query Neighborhood Hits	128	Target Neighborhood Hits	109	Shared Neighborhood Hits	94
SwissProt Accessions	P22932, Q15281	Gene names	RARG, NR1B3
Domain Architecture	No domain graphic available
Description	Retinoic acid receptor gamma-2 (RAR-gamma-2).

RARG2_MOUSE
NC score	0.955964 (rank : 9)	θ value	4.40402e-47 (rank : 8)
Query Neighborhood Hits	128	Target Neighborhood Hits	114	Shared Neighborhood Hits	94
SwissProt Accessions	P20787	Gene names	Rarg, Nr1b3
Domain Architecture
Description	Retinoic acid receptor gamma-B (RAR-gamma-B).

RARG1_HUMAN
NC score	0.955889 (rank : 10)	θ value	1.08474e-45 (rank : 11)
Query Neighborhood Hits	128	Target Neighborhood Hits	107	Shared Neighborhood Hits	94
SwissProt Accessions	P13631	Gene names	RARG, NR1B3
Domain Architecture
Description	Retinoic acid receptor gamma-1 (RAR-gamma-1).

RARG1_MOUSE
NC score	0.955764 (rank : 11)	θ value	4.40402e-47 (rank : 7)
Query Neighborhood Hits	128	Target Neighborhood Hits	113	Shared Neighborhood Hits	94
SwissProt Accessions	P18911, Q91VK5	Gene names	Rarg, Nr1b3
Domain Architecture
Description	Retinoic acid receptor gamma-A (RAR-gamma-A).

RARB_HUMAN
NC score	0.955643 (rank : 12)	θ value	6.35935e-46 (rank : 10)
Query Neighborhood Hits	128	Target Neighborhood Hits	118	Shared Neighborhood Hits	95
SwissProt Accessions	P10826, P12891, Q00989, Q15298, Q9UN48	Gene names	RARB, HAP, NR1B2
Domain Architecture
Description	Retinoic acid receptor beta (RAR-beta) (RAR-epsilon) (HBV-activated protein).

RARA_HUMAN
NC score	0.955340 (rank : 13)	θ value	7.03111e-45 (rank : 13)
Query Neighborhood Hits	128	Target Neighborhood Hits	118	Shared Neighborhood Hits	94
SwissProt Accessions	P10276, P78456, Q13440, Q13441, Q9NQS0	Gene names	RARA, NR1B1
Domain Architecture
Description	Retinoic acid receptor alpha (RAR-alpha).

RARA_MOUSE
NC score	0.955324 (rank : 14)	θ value	1.19932e-44 (rank : 14)
Query Neighborhood Hits	128	Target Neighborhood Hits	113	Shared Neighborhood Hits	94
SwissProt Accessions	P11416, P22603	Gene names	Rara, Nr1b1
Domain Architecture
Description	Retinoic acid receptor alpha (RAR-alpha).

ERR3_HUMAN
NC score	0.952263 (rank : 15)	θ value	2.50074e-42 (rank : 15)
Query Neighborhood Hits	128	Target Neighborhood Hits	106	Shared Neighborhood Hits	94
SwissProt Accessions	P62508, O75454, O96021, Q68DA0, Q6P274, Q6PK28, Q6TS38, Q9R1F3, Q9UNJ4	Gene names	ESRRG, ERR3, ERRG2, KIAA0832, NR3B3
Domain Architecture	No domain graphic available
Description	Estrogen-related receptor gamma (Estrogen receptor-related protein 3) (ERR gamma-2).

ERR3_MOUSE
NC score	0.952263 (rank : 16)	θ value	2.50074e-42 (rank : 16)
Query Neighborhood Hits	128	Target Neighborhood Hits	106	Shared Neighborhood Hits	94
SwissProt Accessions	P62509, O75454, O96021, Q8CHC9, Q9R1F3	Gene names	Esrrg, Err3, Kiaa0832, Nr3b3
Domain Architecture	No domain graphic available
Description	Estrogen-related receptor gamma (Estrogen receptor-related protein 3).

ERR2_MOUSE
NC score	0.950931 (rank : 17)	θ value	6.15952e-41 (rank : 17)
Query Neighborhood Hits	128	Target Neighborhood Hits	109	Shared Neighborhood Hits	94
SwissProt Accessions	Q61539, O09067, O09146	Gene names	Esrrb, Err-2, Err2, Nr3b2
Domain Architecture
Description	Steroid hormone receptor ERR2 (Estrogen-related receptor, beta) (ERR- beta) (Estrogen receptor-like 2).

ERR2_HUMAN
NC score	0.950555 (rank : 18)	θ value	3.99248e-40 (rank : 20)
Query Neighborhood Hits	128	Target Neighborhood Hits	108	Shared Neighborhood Hits	94
SwissProt Accessions	O95718, Q9HCB4	Gene names	ESRRB, ERRB2, NR3B2
Domain Architecture
Description	Steroid hormone receptor ERR2 (Estrogen-related receptor, beta) (ERR- beta) (Estrogen receptor-like 2) (ERR beta-2).

ERR1_HUMAN
NC score	0.950194 (rank : 19)	θ value	1.6247e-33 (rank : 30)
Query Neighborhood Hits	128	Target Neighborhood Hits	157	Shared Neighborhood Hits	94
SwissProt Accessions	P11474, Q14514	Gene names	ESRRA, ERR1, ESRL1, NR3B1
Domain Architecture
Description	Steroid hormone receptor ERR1 (Estrogen-related receptor, alpha) (ERR- alpha) (Estrogen receptor-like 1).

RXRG_MOUSE
NC score	0.943598 (rank : 20)	θ value	4.72714e-33 (rank : 31)
Query Neighborhood Hits	128	Target Neighborhood Hits	113	Shared Neighborhood Hits	94
SwissProt Accessions	P28705	Gene names	Rxrg, Nr2b3
Domain Architecture
Description	Retinoic acid receptor RXR-gamma (Retinoid X receptor gamma).

RXRG_HUMAN
NC score	0.943461 (rank : 21)	θ value	6.17384e-33 (rank : 32)
Query Neighborhood Hits	128	Target Neighborhood Hits	114	Shared Neighborhood Hits	94
SwissProt Accessions	P48443	Gene names	RXRG, NR2B3
Domain Architecture
Description	Retinoic acid receptor RXR-gamma (Retinoid X receptor gamma).

NR1H3_HUMAN
NC score	0.943288 (rank : 22)	θ value	1.9192e-34 (rank : 26)
Query Neighborhood Hits	128	Target Neighborhood Hits	104	Shared Neighborhood Hits	94
SwissProt Accessions	Q13133, Q96H87	Gene names	NR1H3, LXRA
Domain Architecture
Description	Oxysterols receptor LXR-alpha (Liver X receptor alpha) (Nuclear orphan receptor LXR-alpha).

NR1H3_MOUSE
NC score	0.943171 (rank : 23)	θ value	7.29293e-34 (rank : 29)
Query Neighborhood Hits	128	Target Neighborhood Hits	102	Shared Neighborhood Hits	94
SwissProt Accessions	Q9Z0Y9, Q9QUH7	Gene names	Nr1h3, Lxra
Domain Architecture
Description	Oxysterols receptor LXR-alpha (Liver X receptor alpha) (Nuclear orphan receptor LXR-alpha).

RXRA_MOUSE
NC score	0.942554 (rank : 24)	θ value	4.27553e-34 (rank : 28)
Query Neighborhood Hits	128	Target Neighborhood Hits	129	Shared Neighborhood Hits	94
SwissProt Accessions	P28700	Gene names	Rxra, Nr2b1
Domain Architecture
Description	Retinoic acid receptor RXR-alpha (Retinoid X receptor alpha).

ESR1_MOUSE
NC score	0.940338 (rank : 25)	θ value	2.59387e-31 (rank : 34)
Query Neighborhood Hits	128	Target Neighborhood Hits	104	Shared Neighborhood Hits	94
SwissProt Accessions	P19785, Q9JJT5, Q9QY51, Q9QY52	Gene names	Esr1, Esr, Estr, Estra, Nr3a1
Domain Architecture
Description	Estrogen receptor (ER) (Estradiol receptor) (ER-alpha).

RXRA_HUMAN
NC score	0.940157 (rank : 26)	θ value	1.01765e-35 (rank : 24)
Query Neighborhood Hits	128	Target Neighborhood Hits	223	Shared Neighborhood Hits	98
SwissProt Accessions	P19793, Q2V504	Gene names	RXRA, NR2B1
Domain Architecture
Description	Retinoic acid receptor RXR-alpha (Retinoid X receptor alpha).

ESR1_HUMAN
NC score	0.939557 (rank : 27)	θ value	1.0531e-32 (rank : 33)
Query Neighborhood Hits	128	Target Neighborhood Hits	105	Shared Neighborhood Hits	94
SwissProt Accessions	P03372, Q13511, Q14276, Q9NU51, Q9UDZ7, Q9UIS7	Gene names	ESR1, ESR, NR3A1
Domain Architecture
Description	Estrogen receptor (ER) (Estradiol receptor) (ER-alpha).

ESR2_HUMAN
NC score	0.938776 (rank : 28)	θ value	5.96599e-36 (rank : 23)
Query Neighborhood Hits	128	Target Neighborhood Hits	110	Shared Neighborhood Hits	94
SwissProt Accessions	Q92731, O60608, O60685, O60702, O60703, O75583, O75584, Q86Z31, Q9UEV6, Q9UHD3, Q9UQK9	Gene names	ESR2, ESTRB, NR3A2
Domain Architecture
Description	Estrogen receptor beta (ER-beta).

COT2_HUMAN
NC score	0.938328 (rank : 29)	θ value	8.89434e-40 (rank : 21)
Query Neighborhood Hits	128	Target Neighborhood Hits	135	Shared Neighborhood Hits	94
SwissProt Accessions	P24468, Q03754	Gene names	NR2F2, ARP1, TFCOUP2
Domain Architecture
Description	COUP transcription factor 2 (COUP-TF2) (COUP-TF II) (Apolipoprotein AI regulatory protein 1) (ARP-1).

COT2_MOUSE
NC score	0.938328 (rank : 30)	θ value	8.89434e-40 (rank : 22)
Query Neighborhood Hits	128	Target Neighborhood Hits	135	Shared Neighborhood Hits	94
SwissProt Accessions	P43135	Gene names	Nr2f2, Aporp1, Arp-1, Arp1, Tfcoup2
Domain Architecture
Description	COUP transcription factor 2 (COUP-TF2) (COUP-TF II) (Apolipoprotein AI regulatory protein 1) (ARP-1).

EAR2_MOUSE
NC score	0.938135 (rank : 31)	θ value	1.46948e-34 (rank : 25)
Query Neighborhood Hits	128	Target Neighborhood Hits	104	Shared Neighborhood Hits	94
SwissProt Accessions	P43136, Q61504	Gene names	Nr2f6, Ear-2, Ear2, Erbal2
Domain Architecture
Description	Orphan nuclear receptor EAR-2 (V-erbA-related protein EAR-2).

ESR2_MOUSE
NC score	0.938019 (rank : 32)	θ value	3.27365e-34 (rank : 27)
Query Neighborhood Hits	128	Target Neighborhood Hits	110	Shared Neighborhood Hits	94
SwissProt Accessions	O08537, O35635, O70519	Gene names	Esr2, Estrb, Nr3a2
Domain Architecture
Description	Estrogen receptor beta (ER-beta).

COT1_MOUSE
NC score	0.937378 (rank : 33)	θ value	3.99248e-40 (rank : 19)
Query Neighborhood Hits	128	Target Neighborhood Hits	160	Shared Neighborhood Hits	94
SwissProt Accessions	Q60632, Q61438	Gene names	Nr2f1, Erbal3, Tfcoup1
Domain Architecture
Description	COUP transcription factor 1 (COUP-TF1) (COUP-TF I).

EAR2_HUMAN
NC score	0.937282 (rank : 34)	θ value	4.42448e-31 (rank : 35)
Query Neighborhood Hits	128	Target Neighborhood Hits	106	Shared Neighborhood Hits	94
SwissProt Accessions	P10588, Q9BUE8	Gene names	NR2F6, EAR2, ERBAL2
Domain Architecture
Description	Orphan nuclear receptor EAR-2 (V-erbA-related protein EAR-2).

HNF4G_HUMAN
NC score	0.937232 (rank : 35)	θ value	1.28732e-30 (rank : 36)
Query Neighborhood Hits	128	Target Neighborhood Hits	100	Shared Neighborhood Hits	94
SwissProt Accessions	Q14541, Q9UH81, Q9UIS6	Gene names	HNF4G, NR2A2
Domain Architecture
Description	Hepatocyte nuclear factor 4-gamma (HNF-4-gamma).

RXRB_MOUSE
NC score	0.937113 (rank : 36)	θ value	2.86786e-30 (rank : 39)
Query Neighborhood Hits	128	Target Neighborhood Hits	230	Shared Neighborhood Hits	95
SwissProt Accessions	P28704, P33243	Gene names	Rxrb, Nr2b2
Domain Architecture
Description	Retinoic acid receptor RXR-beta (Retinoid X receptor beta) (MHC class I regulatory element-binding protein H-2RIIBP).

COT1_HUMAN
NC score	0.937073 (rank : 37)	θ value	3.99248e-40 (rank : 18)
Query Neighborhood Hits	128	Target Neighborhood Hits	159	Shared Neighborhood Hits	94
SwissProt Accessions	P10589	Gene names	NR2F1, EAR3, ERBAL3, TFCOUP1
Domain Architecture
Description	COUP transcription factor 1 (COUP-TF1) (COUP-TF I) (V-ERBA-related protein EAR-3).

NR1H4_HUMAN
NC score	0.936853 (rank : 38)	θ value	7.06379e-29 (rank : 44)
Query Neighborhood Hits	128	Target Neighborhood Hits	112	Shared Neighborhood Hits	94
SwissProt Accessions	Q96RI1, Q8NFP5, Q8NFP6, Q92943	Gene names	NR1H4, BAR, FXR, HRR1, RIP14
Domain Architecture
Description	Bile acid receptor (Farnesoid X-activated receptor) (Farnesol receptor HRR-1) (Retinoid X receptor-interacting protein 14) (RXR-interacting protein 14).

HNF4G_MOUSE
NC score	0.936230 (rank : 39)	θ value	2.42779e-29 (rank : 42)
Query Neighborhood Hits	128	Target Neighborhood Hits	101	Shared Neighborhood Hits	94
SwissProt Accessions	Q9WUU6	Gene names	Hnf4g, Nr2a2
Domain Architecture
Description	Hepatocyte nuclear factor 4-gamma (HNF-4-gamma).

NR1H4_MOUSE
NC score	0.936211 (rank : 40)	θ value	4.57862e-28 (rank : 51)
Query Neighborhood Hits	128	Target Neighborhood Hits	113	Shared Neighborhood Hits	94
SwissProt Accessions	Q60641, Q60642, Q60643	Gene names	Nr1h4, Bar, Fxr, Rip14
Domain Architecture
Description	Bile acid receptor (Farnesoid X-activated receptor) (Farnesol receptor HRR-1) (Retinoid X receptor-interacting protein 14) (RXR-interacting protein 14).

NR1I3_MOUSE
NC score	0.935119 (rank : 41)	θ value	1.5242e-23 (rank : 65)
Query Neighborhood Hits	128	Target Neighborhood Hits	103	Shared Neighborhood Hits	94
SwissProt Accessions	O35627, O35628	Gene names	Nr1i3, Car
Domain Architecture
Description	Orphan nuclear receptor NR1I3 (Constitutive androstane receptor) (CAR) (Orphan nuclear receptor MB67).

HNF4A_HUMAN
NC score	0.934833 (rank : 42)	θ value	4.57862e-28 (rank : 50)
Query Neighborhood Hits	128	Target Neighborhood Hits	105	Shared Neighborhood Hits	94
SwissProt Accessions	P41235, O00659, O00723, Q14540, Q92653, Q92654, Q92655, Q99864, Q9NQH0	Gene names	HNF4A, HNF4, NR2A1, TCF14
Domain Architecture
Description	Hepatocyte nuclear factor 4-alpha (HNF-4-alpha) (Transcription factor HNF-4) (Transcription factor 14).

HNF4A_MOUSE
NC score	0.934805 (rank : 43)	θ value	2.96777e-27 (rank : 53)
Query Neighborhood Hits	128	Target Neighborhood Hits	103	Shared Neighborhood Hits	94
SwissProt Accessions	P49698	Gene names	Hnf4a, Hnf-4, Hnf4, Nr2a1, Tcf14
Domain Architecture
Description	Hepatocyte nuclear factor 4-alpha (HNF-4-alpha) (Transcription factor HNF-4) (Transcription factor 14).

RXRB_HUMAN
NC score	0.934555 (rank : 44)	θ value	1.6813e-30 (rank : 38)
Query Neighborhood Hits	128	Target Neighborhood Hits	280	Shared Neighborhood Hits	96
SwissProt Accessions	P28702, P28703	Gene names	RXRB, NR2B2
Domain Architecture
Description	Retinoic acid receptor RXR-beta (Retinoid X receptor beta).

NR2E3_MOUSE
NC score	0.933638 (rank : 45)	θ value	5.40856e-29 (rank : 43)
Query Neighborhood Hits	128	Target Neighborhood Hits	113	Shared Neighborhood Hits	94
SwissProt Accessions	Q9QXZ7	Gene names	Nr2e3, Pnr, Rnr
Domain Architecture
Description	Photoreceptor-specific nuclear receptor (Retina-specific nuclear receptor).

NR1H2_MOUSE
NC score	0.933091 (rank : 46)	θ value	1.24688e-25 (rank : 57)
Query Neighborhood Hits	128	Target Neighborhood Hits	109	Shared Neighborhood Hits	95
SwissProt Accessions	Q60644	Gene names	Nr1h2, Lxrb, Rip15, Unr, Unr2
Domain Architecture
Description	Oxysterols receptor LXR-beta (Liver X receptor beta) (Nuclear orphan receptor LXR-beta) (Ubiquitously-expressed nuclear receptor) (Retinoid X receptor-interacting protein No.15).

NR2E1_MOUSE
NC score	0.932780 (rank : 47)	θ value	1.62847e-25 (rank : 58)
Query Neighborhood Hits	128	Target Neighborhood Hits	106	Shared Neighborhood Hits	94
SwissProt Accessions	Q64104	Gene names	Nr2e1, Tll, Tlx
Domain Architecture
Description	Orphan nuclear receptor NR2E1 (Nuclear receptor TLX) (Tailless homolog) (Tll) (mTll).

NR2E3_HUMAN
NC score	0.932671 (rank : 48)	θ value	7.06379e-29 (rank : 45)
Query Neighborhood Hits	128	Target Neighborhood Hits	102	Shared Neighborhood Hits	94
SwissProt Accessions	Q9Y5X4, Q9UHM4	Gene names	NR2E3, PNR, RNR
Domain Architecture
Description	Photoreceptor-specific nuclear receptor (Retina-specific nuclear receptor).

THA_MOUSE
NC score	0.932322 (rank : 49)	θ value	1.08979e-29 (rank : 41)
Query Neighborhood Hits	128	Target Neighborhood Hits	113	Shared Neighborhood Hits	94
SwissProt Accessions	P63058, P10685, P15827, P16416, P37241, Q63107, Q63195, Q63196, Q99146	Gene names	Thra, C-erba-alpha, Nr1a1
Domain Architecture	No domain graphic available
Description	Thyroid hormone receptor alpha (C-erbA-alpha) (c-erbA-1).

THA_HUMAN
NC score	0.932205 (rank : 50)	θ value	1.08979e-29 (rank : 40)
Query Neighborhood Hits	128	Target Neighborhood Hits	113	Shared Neighborhood Hits	94
SwissProt Accessions	P10827, P21205, Q8N6A1, Q96H73	Gene names	THRA, ERBA1, NR1A1, THRA1
Domain Architecture
Description	Thyroid hormone receptor alpha (C-erbA-alpha) (c-erbA-1) (EAR-7) (EAR7).

NR2E1_HUMAN
NC score	0.931606 (rank : 51)	θ value	1.5242e-23 (rank : 66)
Query Neighborhood Hits	128	Target Neighborhood Hits	103	Shared Neighborhood Hits	94
SwissProt Accessions	Q9Y466	Gene names	NR2E1, TLX
Domain Architecture
Description	Orphan nuclear receptor NR2E1 (Nuclear receptor TLX) (Tailless homolog) (Tll) (hTll).

NR1I3_HUMAN
NC score	0.929401 (rank : 52)	θ value	2.35696e-16 (rank : 93)
Query Neighborhood Hits	128	Target Neighborhood Hits	107	Shared Neighborhood Hits	94
SwissProt Accessions	Q14994	Gene names	NR1I3, CAR
Domain Architecture
Description	Orphan nuclear receptor NR1I3 (Constitutive androstane receptor) (CAR) (Constitutive activator of retinoid response) (Constitutive active response) (Orphan nuclear receptor MB67).

THB2_HUMAN
NC score	0.926726 (rank : 53)	θ value	2.05525e-28 (rank : 48)
Query Neighborhood Hits	128	Target Neighborhood Hits	104	Shared Neighborhood Hits	94
SwissProt Accessions	P37243	Gene names	THRB, ERBA2, NR1A2, THR1
Domain Architecture	No domain graphic available
Description	Thyroid hormone receptor beta-2.

THB1_HUMAN
NC score	0.926525 (rank : 54)	θ value	2.68423e-28 (rank : 49)
Query Neighborhood Hits	128	Target Neighborhood Hits	106	Shared Neighborhood Hits	94
SwissProt Accessions	P10828, Q13986	Gene names	THRB, ERBA2, NR1A2, THR1
Domain Architecture
Description	Thyroid hormone receptor beta-1.

THB2_MOUSE
NC score	0.925775 (rank : 55)	θ value	1.2049e-28 (rank : 47)
Query Neighborhood Hits	128	Target Neighborhood Hits	106	Shared Neighborhood Hits	94
SwissProt Accessions	P37244	Gene names	Thrb, C-erba-beta, Nr1a2
Domain Architecture
Description	Thyroid hormone receptor beta-2.

THB1_MOUSE
NC score	0.925685 (rank : 56)	θ value	1.2049e-28 (rank : 46)
Query Neighborhood Hits	128	Target Neighborhood Hits	105	Shared Neighborhood Hits	94
SwissProt Accessions	P37242	Gene names	Thrb, C-erba-beta, Nr1a2
Domain Architecture
Description	Thyroid hormone receptor beta-1.

NR6A1_HUMAN
NC score	0.924182 (rank : 57)	θ value	2.06002e-20 (rank : 86)
Query Neighborhood Hits	128	Target Neighborhood Hits	108	Shared Neighborhood Hits	94
SwissProt Accessions	Q15406, O00551, O00603, Q8NHQ0, Q92898, Q99802	Gene names	NR6A1, GCNF
Domain Architecture
Description	Orphan nuclear receptor NR6A1 (Germ cell nuclear factor) (GCNF) (Retinoid receptor-related testis-specific receptor) (RTR).

PPARD_HUMAN
NC score	0.923867 (rank : 58)	θ value	1.02001e-27 (rank : 52)
Query Neighborhood Hits	128	Target Neighborhood Hits	102	Shared Neighborhood Hits	94
SwissProt Accessions	Q03181, Q7Z5K0, Q9BUD4	Gene names	PPARD, NR1C2, PPARB
Domain Architecture
Description	Peroxisome proliferator-activated receptor delta (PPAR-delta) (PPAR- beta) (Nuclear hormone receptor 1) (NUC1) (NUCI).

NR1D1_HUMAN
NC score	0.923746 (rank : 59)	θ value	2.43343e-21 (rank : 77)
Query Neighborhood Hits	128	Target Neighborhood Hits	140	Shared Neighborhood Hits	95
SwissProt Accessions	P20393, Q15304	Gene names	NR1D1, EAR1, HREV, THRAL
Domain Architecture
Description	Orphan nuclear receptor NR1D1 (V-erbA-related protein EAR-1) (Rev- erbA-alpha).

PPARD_MOUSE
NC score	0.923673 (rank : 60)	θ value	1.28732e-30 (rank : 37)
Query Neighborhood Hits	128	Target Neighborhood Hits	103	Shared Neighborhood Hits	94
SwissProt Accessions	P35396, P37239	Gene names	Ppard, Nr1c2, Pparb
Domain Architecture
Description	Peroxisome proliferator-activated receptor delta (PPAR-delta) (PPAR- beta) (Nuclear hormone receptor 1) (NUC1).

NR6A1_MOUSE
NC score	0.923622 (rank : 61)	θ value	2.06002e-20 (rank : 87)
Query Neighborhood Hits	128	Target Neighborhood Hits	110	Shared Neighborhood Hits	94
SwissProt Accessions	Q64249	Gene names	Nr6a1, Gcnf
Domain Architecture
Description	Orphan nuclear receptor NR6A1 (Germ cell nuclear factor) (GCNF) (Retinoid receptor-related testis-specific receptor) (RTR).

STF1_HUMAN
NC score	0.923249 (rank : 62)	θ value	4.01107e-24 (rank : 62)
Query Neighborhood Hits	128	Target Neighborhood Hits	132	Shared Neighborhood Hits	95
SwissProt Accessions	Q13285, O15196	Gene names	NR5A1, AD4BP, FTZF1, SF1
Domain Architecture
Description	Steroidogenic factor 1 (STF-1) (SF-1) (Adrenal 4-binding protein) (Steroid hormone receptor Ad4BP) (Fushi tarazu factor homolog 1).

PPARA_MOUSE
NC score	0.923136 (rank : 63)	θ value	1.37858e-24 (rank : 61)
Query Neighborhood Hits	128	Target Neighborhood Hits	99	Shared Neighborhood Hits	94
SwissProt Accessions	P23204	Gene names	Ppara, Nr1c1, Ppar
Domain Architecture
Description	Peroxisome proliferator-activated receptor alpha (PPAR-alpha).

STF1_MOUSE
NC score	0.922409 (rank : 64)	θ value	4.01107e-24 (rank : 63)
Query Neighborhood Hits	128	Target Neighborhood Hits	137	Shared Neighborhood Hits	94
SwissProt Accessions	P33242	Gene names	Nr5a1, Ftzf1
Domain Architecture
Description	Steroidogenic factor 1 (STF-1) (SF-1) (Adrenal 4-binding protein) (Steroid hormone receptor Ad4BP) (Fushi tarazu factor homolog 1) (Embryonal LTR-binding protein) (ELP) (Embryonal long terminal repeat- binding protein) (Steroid hydroxylase positive regulator).

PPARG_HUMAN
NC score	0.922218 (rank : 65)	θ value	3.28125e-26 (rank : 55)
Query Neighborhood Hits	128	Target Neighborhood Hits	97	Shared Neighborhood Hits	94
SwissProt Accessions	P37231, O00684, O00710, O14515, Q15178, Q15179, Q15180, Q15832, Q86U60, Q96J12	Gene names	PPARG, NR1C3
Domain Architecture
Description	Peroxisome proliferator-activated receptor gamma (PPAR-gamma).

PPARA_HUMAN
NC score	0.922101 (rank : 66)	θ value	1.37858e-24 (rank : 60)
Query Neighborhood Hits	128	Target Neighborhood Hits	100	Shared Neighborhood Hits	94
SwissProt Accessions	Q07869, Q16241, Q92486, Q92689, Q9Y3N1	Gene names	PPARA, NR1C1, PPAR
Domain Architecture
Description	Peroxisome proliferator-activated receptor alpha (PPAR-alpha).

PPARG_MOUSE
NC score	0.922093 (rank : 67)	θ value	3.28125e-26 (rank : 56)
Query Neighborhood Hits	128	Target Neighborhood Hits	97	Shared Neighborhood Hits	94
SwissProt Accessions	P37238	Gene names	Pparg, Nr1c3
Domain Architecture
Description	Peroxisome proliferator-activated receptor gamma (PPAR-gamma).

NR1H2_HUMAN
NC score	0.921782 (rank : 68)	θ value	5.79196e-23 (rank : 69)
Query Neighborhood Hits	128	Target Neighborhood Hits	114	Shared Neighborhood Hits	95
SwissProt Accessions	P55055, Q12970	Gene names	NR1H2, LXRB, NER, UNR
Domain Architecture
Description	Oxysterols receptor LXR-beta (Liver X receptor beta) (Nuclear orphan receptor LXR-beta) (Ubiquitously-expressed nuclear receptor) (Nuclear receptor NER).

TR2_HUMAN
NC score	0.920103 (rank : 69)	θ value	6.40375e-22 (rank : 75)
Query Neighborhood Hits	128	Target Neighborhood Hits	110	Shared Neighborhood Hits	95
SwissProt Accessions	P13056	Gene names	NR2C1, TR2
Domain Architecture
Description	Orphan nuclear receptor TR2 (Testicular receptor 2).

VDR_MOUSE
NC score	0.919247 (rank : 70)	θ value	7.0802e-21 (rank : 82)
Query Neighborhood Hits	128	Target Neighborhood Hits	103	Shared Neighborhood Hits	94
SwissProt Accessions	P48281	Gene names	Vdr, Nr1i1
Domain Architecture
Description	Vitamin D3 receptor (VDR) (1,25-dihydroxyvitamin D3 receptor).

PXR_HUMAN
NC score	0.918696 (rank : 71)	θ value	6.84181e-24 (rank : 64)
Query Neighborhood Hits	128	Target Neighborhood Hits	107	Shared Neighborhood Hits	94
SwissProt Accessions	O75469, Q96AC7, Q9UJ22, Q9UJ23, Q9UJ24, Q9UJ25, Q9UJ26, Q9UJ27	Gene names	NR1I2, PXR
Domain Architecture
Description	Orphan nuclear receptor PXR (Pregnane X receptor) (Orphan nuclear receptor PAR1) (Steroid and xenobiotic receptor) (SXR).

NR1D2_HUMAN
NC score	0.918164 (rank : 72)	θ value	1.6852e-22 (rank : 71)
Query Neighborhood Hits	128	Target Neighborhood Hits	115	Shared Neighborhood Hits	94
SwissProt Accessions	Q14995, O00402, Q86XD4	Gene names	NR1D2
Domain Architecture
Description	Orphan nuclear receptor NR1D2 (Rev-erb-beta) (EAR-1R) (Orphan nuclear hormone receptor BD73).

PXR_MOUSE
NC score	0.917115 (rank : 73)	θ value	9.87957e-23 (rank : 70)
Query Neighborhood Hits	128	Target Neighborhood Hits	107	Shared Neighborhood Hits	94
SwissProt Accessions	O54915	Gene names	Nr1i2, Pxr
Domain Architecture
Description	Orphan nuclear receptor PXR (Pregnane X receptor).

NR5A2_HUMAN
NC score	0.916308 (rank : 74)	θ value	1.47289e-26 (rank : 54)
Query Neighborhood Hits	128	Target Neighborhood Hits	112	Shared Neighborhood Hits	95
SwissProt Accessions	O00482, O95642	Gene names	NR5A2, B1F, CPF, FTF
Domain Architecture
Description	Orphan nuclear receptor NR5A2 (Alpha-1-fetoprotein transcription factor) (Hepatocytic transcription factor) (B1-binding factor) (hB1F) (CYP7A promoter-binding factor) (Liver receptor homolog 1) (LRH-1).

NR5A2_MOUSE
NC score	0.915950 (rank : 75)	θ value	1.05554e-24 (rank : 59)
Query Neighborhood Hits	128	Target Neighborhood Hits	107	Shared Neighborhood Hits	94
SwissProt Accessions	P45448	Gene names	Nr5a2, Lrh1
Domain Architecture
Description	Orphan nuclear receptor NR5A2 (Liver receptor homolog 1) (LRH-1).

VDR_HUMAN
NC score	0.915859 (rank : 76)	θ value	2.5182e-18 (rank : 91)
Query Neighborhood Hits	128	Target Neighborhood Hits	112	Shared Neighborhood Hits	94
SwissProt Accessions	P11473	Gene names	VDR, NR1I1
Domain Architecture
Description	Vitamin D3 receptor (VDR) (1,25-dihydroxyvitamin D3 receptor).

NR1D2_MOUSE
NC score	0.915747 (rank : 77)	θ value	2.20094e-22 (rank : 72)
Query Neighborhood Hits	128	Target Neighborhood Hits	109	Shared Neighborhood Hits	94
SwissProt Accessions	Q60674, Q60646	Gene names	Nr1d2
Domain Architecture
Description	Orphan nuclear receptor NR1D2 (Rev-erb-beta) (Orphan nuclear receptor RVR).

TR2_MOUSE
NC score	0.905599 (rank : 78)	θ value	4.9032e-22 (rank : 74)
Query Neighborhood Hits	128	Target Neighborhood Hits	100	Shared Neighborhood Hits	94
SwissProt Accessions	Q505F1, P97763, Q3UIJ7, Q4U1Z4, Q60927, Q62152, Q8VIJ3	Gene names	Nr2c1, Tr2, Tr2-11
Domain Architecture	No domain graphic available
Description	Orphan nuclear receptor TR2 (Testicular receptor 2) (mTR2).

RORG_MOUSE
NC score	0.904962 (rank : 79)	θ value	7.0802e-21 (rank : 81)
Query Neighborhood Hits	128	Target Neighborhood Hits	107	Shared Neighborhood Hits	94
SwissProt Accessions	P51450, Q61027, Q91YT5, Q9QXD9, Q9R177	Gene names	Rorc, Nr1f3, Rorg, Thor
Domain Architecture
Description	Nuclear receptor ROR-gamma (Nuclear receptor RZR-gamma) (Thymus orphan receptor) (TOR).

RORA_HUMAN
NC score	0.902521 (rank : 80)	θ value	4.15078e-21 (rank : 78)
Query Neighborhood Hits	128	Target Neighborhood Hits	105	Shared Neighborhood Hits	94
SwissProt Accessions	P35398, P35397, P35399, P45445, Q96H83	Gene names	RORA, NR1F1, RZRA
Domain Architecture
Description	Nuclear receptor ROR-alpha (Nuclear receptor RZR-alpha).

RORB_MOUSE
NC score	0.902467 (rank : 81)	θ value	1.2077e-20 (rank : 85)
Query Neighborhood Hits	128	Target Neighborhood Hits	99	Shared Neighborhood Hits	94
SwissProt Accessions	Q8R1B8	Gene names	Rorb, Nr1f2
Domain Architecture
Description	Nuclear receptor ROR-beta (Nuclear receptor RZR-beta).

RORB_HUMAN
NC score	0.902318 (rank : 82)	θ value	1.2077e-20 (rank : 84)
Query Neighborhood Hits	128	Target Neighborhood Hits	99	Shared Neighborhood Hits	94
SwissProt Accessions	Q92753, Q8WX73	Gene names	RORB, NR1F2, RZRB
Domain Architecture
Description	Nuclear receptor ROR-beta (Nuclear receptor RZR-beta).

RORA_MOUSE
NC score	0.901924 (rank : 83)	θ value	4.15078e-21 (rank : 79)
Query Neighborhood Hits	128	Target Neighborhood Hits	105	Shared Neighborhood Hits	94
SwissProt Accessions	P51448, P70283, P97741, P97773, Q923G1	Gene names	Rora, Nr1f1, Rzra
Domain Architecture
Description	Nuclear receptor ROR-alpha (Nuclear receptor RZR-alpha).

RORG_HUMAN
NC score	0.901175 (rank : 84)	θ value	7.0802e-21 (rank : 80)
Query Neighborhood Hits	128	Target Neighborhood Hits	119	Shared Neighborhood Hits	94
SwissProt Accessions	P51449, Q8N5V7, Q8NCY8	Gene names	RORC, NR1F3, RORG, RZRG
Domain Architecture
Description	Nuclear receptor ROR-gamma (Nuclear receptor RZR-gamma).

TR4_HUMAN
NC score	0.900744 (rank : 85)	θ value	2.20094e-22 (rank : 73)
Query Neighborhood Hits	128	Target Neighborhood Hits	117	Shared Neighborhood Hits	94
SwissProt Accessions	P49116, P55092	Gene names	NR2C2, TAK1, TR4
Domain Architecture
Description	Orphan nuclear receptor TR4 (Orphan nuclear receptor TAK1).

TR4_MOUSE
NC score	0.899901 (rank : 86)	θ value	8.36355e-22 (rank : 76)
Query Neighborhood Hits	128	Target Neighborhood Hits	115	Shared Neighborhood Hits	94
SwissProt Accessions	P49117, P55093	Gene names	Nr2c2, Mtr2r1, Tak1, Tr4
Domain Architecture
Description	Orphan nuclear receptor TR4 (Orphan nuclear receptor TAK1).

GCR_HUMAN
NC score	0.886887 (rank : 87)	θ value	1.99067e-23 (rank : 67)
Query Neighborhood Hits	128	Target Neighborhood Hits	113	Shared Neighborhood Hits	94
SwissProt Accessions	P04150, P04151, Q53EP5, Q6N0A4	Gene names	NR3C1, GRL
Domain Architecture
Description	Glucocorticoid receptor (GR).

GCR_MOUSE
NC score	0.882158 (rank : 88)	θ value	1.99067e-23 (rank : 68)
Query Neighborhood Hits	128	Target Neighborhood Hits	117	Shared Neighborhood Hits	94
SwissProt Accessions	P06537, Q61628, Q61629	Gene names	Nr3c1, Grl, Grl1
Domain Architecture
Description	Glucocorticoid receptor (GR).

ANDR_MOUSE
NC score	0.880789 (rank : 89)	θ value	9.24701e-21 (rank : 83)
Query Neighborhood Hits	128	Target Neighborhood Hits	133	Shared Neighborhood Hits	94
SwissProt Accessions	P19091	Gene names	Ar, Nr3c4
Domain Architecture
Description	Androgen receptor (Dihydrotestosterone receptor).

ANDR_HUMAN
NC score	0.878530 (rank : 90)	θ value	1.33526e-19 (rank : 90)
Query Neighborhood Hits	128	Target Neighborhood Hits	126	Shared Neighborhood Hits	94
SwissProt Accessions	P10275	Gene names	AR, DHTR, NR3C4
Domain Architecture
Description	Androgen receptor (Dihydrotestosterone receptor).

MCR_HUMAN
NC score	0.877699 (rank : 91)	θ value	7.32683e-18 (rank : 92)
Query Neighborhood Hits	128	Target Neighborhood Hits	149	Shared Neighborhood Hits	95
SwissProt Accessions	P08235, Q96KQ8, Q96KQ9	Gene names	NR3C2, MCR, MLR
Domain Architecture
Description	Mineralocorticoid receptor (MR).

MCR_MOUSE
NC score	0.873678 (rank : 92)	θ value	1.99529e-15 (rank : 94)
Query Neighborhood Hits	128	Target Neighborhood Hits	162	Shared Neighborhood Hits	94
SwissProt Accessions	Q8VII8, Q8VII9	Gene names	Nr3c2, Mlr
Domain Architecture	No domain graphic available
Description	Mineralocorticoid receptor (MR).

PRGR_HUMAN
NC score	0.872771 (rank : 93)	θ value	1.02238e-19 (rank : 89)
Query Neighborhood Hits	128	Target Neighborhood Hits	163	Shared Neighborhood Hits	96
SwissProt Accessions	P06401, Q9UPF7	Gene names	PGR, NR3C3
Domain Architecture
Description	Progesterone receptor (PR).

PRGR_MOUSE
NC score	0.867849 (rank : 94)	θ value	2.06002e-20 (rank : 88)
Query Neighborhood Hits	128	Target Neighborhood Hits	286	Shared Neighborhood Hits	96
SwissProt Accessions	Q00175	Gene names	Pgr, Nr3c3, Pr
Domain Architecture
Description	Progesterone receptor (PR).

SHP_HUMAN
NC score	0.439276 (rank : 95)	θ value	θ > 10 (rank : 131)
Query Neighborhood Hits	128	Target Neighborhood Hits	57	Shared Neighborhood Hits	52
SwissProt Accessions	Q15466, Q5QP36	Gene names	NR0B2, SHP
Domain Architecture
Description	Nuclear receptor 0B2 (Orphan nuclear receptor SHP) (Small heterodimer partner).

DAX1_MOUSE
NC score	0.430791 (rank : 96)	θ value	θ > 10 (rank : 130)
Query Neighborhood Hits	128	Target Neighborhood Hits	70	Shared Neighborhood Hits	56
SwissProt Accessions	Q61066, O09068, O09147	Gene names	Nr0b1, Ahch, Dax1
Domain Architecture
Description	Nuclear receptor 0B1 (Nuclear receptor DAX-1).

SHP_MOUSE
NC score	0.429365 (rank : 97)	θ value	θ > 10 (rank : 132)
Query Neighborhood Hits	128	Target Neighborhood Hits	53	Shared Neighborhood Hits	49
SwissProt Accessions	Q62227, Q53Z53	Gene names	Nr0b2, Shp
Domain Architecture
Description	Nuclear receptor 0B2 (Orphan nuclear receptor SHP) (Small heterodimer partner).

DAX1_HUMAN
NC score	0.399291 (rank : 98)	θ value	θ > 10 (rank : 129)
Query Neighborhood Hits	128	Target Neighborhood Hits	65	Shared Neighborhood Hits	55
SwissProt Accessions	P51843, Q96F69	Gene names	NR0B1, AHC, DAX1
Domain Architecture
Description	Nuclear receptor 0B1 (Nuclear receptor DAX-1) (DSS-AHC critical region on the X chromosome protein 1).

SC24C_HUMAN
NC score	0.024891 (rank : 99)	θ value	0.163984 (rank : 96)
Query Neighborhood Hits	128	Target Neighborhood Hits	662	Shared Neighborhood Hits	16
SwissProt Accessions	P53992, Q8WV25	Gene names	SEC24C, KIAA0079
Domain Architecture
Description	Protein transport protein Sec24C (SEC24-related protein C).

TROAP_HUMAN
NC score	0.023781 (rank : 100)	θ value	0.365318 (rank : 97)
Query Neighborhood Hits	128	Target Neighborhood Hits	258	Shared Neighborhood Hits	6
SwissProt Accessions	Q12815	Gene names	TROAP
Domain Architecture	No domain graphic available
Description	Trophinin-associated protein (Tastin) (Trophinin-assisting protein).

CO002_HUMAN
NC score	0.014906 (rank : 101)	θ value	1.06291 (rank : 103)
Query Neighborhood Hits	128	Target Neighborhood Hits	387	Shared Neighborhood Hits	8
SwissProt Accessions	Q9NZP6	Gene names	C15orf2
Domain Architecture	No domain graphic available
Description	Protein C15orf2.

PHF12_HUMAN
NC score	0.013981 (rank : 102)	θ value	0.813845 (rank : 102)
Query Neighborhood Hits	128	Target Neighborhood Hits	174	Shared Neighborhood Hits	5
SwissProt Accessions	Q96QT6, Q6ZML2, Q9BV34, Q9H7U9, Q9P205	Gene names	PHF12, KIAA1523
Domain Architecture	No domain graphic available
Description	PHD finger protein 12 (PHD factor 1) (Pf1).

TSC1_HUMAN
NC score	0.013822 (rank : 103)	θ value	0.0431538 (rank : 95)
Query Neighborhood Hits	128	Target Neighborhood Hits	765	Shared Neighborhood Hits	9
SwissProt Accessions	Q92574	Gene names	TSC1, KIAA0243, TSC
Domain Architecture
Description	Hamartin (Tuberous sclerosis 1 protein).

PHF12_MOUSE
NC score	0.013691 (rank : 104)	θ value	2.36792 (rank : 106)
Query Neighborhood Hits	128	Target Neighborhood Hits	172	Shared Neighborhood Hits	5
SwissProt Accessions	Q5SPL2, Q5SPL3, Q6ZPN8, Q80W50	Gene names	Phf12, Kiaa1523
Domain Architecture	No domain graphic available
Description	PHD finger protein 12 (PHD factor 1) (Pf1).

SNX19_HUMAN
NC score	0.013453 (rank : 105)	θ value	1.06291 (rank : 104)
Query Neighborhood Hits	128	Target Neighborhood Hits	123	Shared Neighborhood Hits	2
SwissProt Accessions	Q92543	Gene names	SNX19, KIAA0254
Domain Architecture
Description	Sorting nexin-19.

K0423_MOUSE
NC score	0.012436 (rank : 106)	θ value	3.0926 (rank : 109)
Query Neighborhood Hits	128	Target Neighborhood Hits	115	Shared Neighborhood Hits	3
SwissProt Accessions	Q6A070	Gene names	Kiaa0423
Domain Architecture	No domain graphic available
Description	Protein KIAA0423.

EVC_MOUSE
NC score	0.007654 (rank : 107)	θ value	8.99809 (rank : 125)
Query Neighborhood Hits	128	Target Neighborhood Hits	80	Shared Neighborhood Hits	3
SwissProt Accessions	P57680	Gene names	Evc
Domain Architecture	No domain graphic available
Description	Ellis-van Creveld syndrome protein homolog.

SMAL1_HUMAN
NC score	0.007178 (rank : 108)	θ value	0.47712 (rank : 99)
Query Neighborhood Hits	128	Target Neighborhood Hits	174	Shared Neighborhood Hits	4
SwissProt Accessions	Q9NZC9, Q96AY1, Q9NXQ5, Q9UFH3, Q9UI93	Gene names	SMARCAL1, HARP
Domain Architecture	No domain graphic available
Description	SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A-like protein 1 (EC 3.6.1.-) (Sucrose nonfermenting protein 2-like 1) (HepA-related protein) (hHARP).

CI079_HUMAN
NC score	0.007154 (rank : 109)	θ value	5.27518 (rank : 114)
Query Neighborhood Hits	128	Target Neighborhood Hits	288	Shared Neighborhood Hits	7
SwissProt Accessions	Q6ZUB1, Q5SQC9, Q8NA41, Q8ND27	Gene names	C9orf79
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C9orf79.

ENAH_MOUSE
NC score	0.005448 (rank : 110)	θ value	4.03905 (rank : 110)
Query Neighborhood Hits	128	Target Neighborhood Hits	919	Shared Neighborhood Hits	16
SwissProt Accessions	Q03173, P70430, P70431, P70432, P70433, Q5D053	Gene names	Enah, Mena, Ndpp1
Domain Architecture
Description	Protein enabled homolog (NPC-derived proline-rich protein 1) (NDPP-1).

CBX2_MOUSE
NC score	0.005169 (rank : 111)	θ value	6.88961 (rank : 118)
Query Neighborhood Hits	128	Target Neighborhood Hits	119	Shared Neighborhood Hits	3
SwissProt Accessions	P30658, O35731, Q8CIA0	Gene names	Cbx2, M33
Domain Architecture
Description	Chromobox protein homolog 2 (Modifier 3 protein) (M33).

FHOD1_MOUSE
NC score	0.004999 (rank : 112)	θ value	3.0926 (rank : 108)
Query Neighborhood Hits	128	Target Neighborhood Hits	217	Shared Neighborhood Hits	5
SwissProt Accessions	Q6P9Q4, Q8BMK2	Gene names	Fhod1, Fhos1
Domain Architecture	No domain graphic available
Description	FH1/FH2 domain-containing protein (Formin homolog overexpressed in spleen) (FHOS) (Formin homology 2 domain-containing protein 1).

SRBP1_HUMAN
NC score	0.004723 (rank : 113)	θ value	6.88961 (rank : 121)
Query Neighborhood Hits	128	Target Neighborhood Hits	225	Shared Neighborhood Hits	5
SwissProt Accessions	P36956, Q16062	Gene names	SREBF1, SREBP1
Domain Architecture
Description	Sterol regulatory element-binding protein 1 (SREBP-1) (Sterol regulatory element-binding transcription factor 1).

ZIMP7_HUMAN
NC score	0.004683 (rank : 114)	θ value	2.36792 (rank : 107)
Query Neighborhood Hits	128	Target Neighborhood Hits	290	Shared Neighborhood Hits	6
SwissProt Accessions	Q8NF64, O94790, Q659A8, Q6JKL5, Q8WTX8, Q96Q01, Q9BQH7	Gene names	ZIMP7, KIAA1886
Domain Architecture	No domain graphic available
Description	PIAS-like protein Zimp7.

SYNG_HUMAN
NC score	0.003980 (rank : 115)	θ value	6.88961 (rank : 123)
Query Neighborhood Hits	128	Target Neighborhood Hits	160	Shared Neighborhood Hits	4
SwissProt Accessions	Q9UMZ2, Q6ZT17	Gene names	AP1GBP1, SYNG
Domain Architecture	No domain graphic available
Description	AP1 subunit gamma-binding protein 1 (Gamma-synergin).

HRBL_MOUSE
NC score	0.003950 (rank : 116)	θ value	5.27518 (rank : 117)
Query Neighborhood Hits	128	Target Neighborhood Hits	269	Shared Neighborhood Hits	8
SwissProt Accessions	Q80WC7, Q8BKS5, Q99J67	Gene names	Hrbl, Rabr
Domain Architecture
Description	HIV-1 Rev-binding protein-like protein (Rev/Rex activation domain- binding protein related) (RAB-R).

DLGP3_MOUSE
NC score	0.003674 (rank : 117)	θ value	5.27518 (rank : 116)
Query Neighborhood Hits	128	Target Neighborhood Hits	56	Shared Neighborhood Hits	2
SwissProt Accessions	Q6PFD5, Q6PDX0, Q6XBF2	Gene names	Dlgap3, Dap3
Domain Architecture	No domain graphic available
Description	Disks large-associated protein 3 (DAP-3) (SAP90/PSD-95-associated protein 3) (SAPAP3) (PSD-95/SAP90-binding protein 3).

DC1L2_MOUSE
NC score	0.003467 (rank : 118)	θ value	5.27518 (rank : 115)
Query Neighborhood Hits	128	Target Neighborhood Hits	173	Shared Neighborhood Hits	3
SwissProt Accessions	Q6PDL0	Gene names	Dync1li2, Dncli2, Dnclic2
Domain Architecture	No domain graphic available
Description	Cytoplasmic dynein 1 light intermediate chain 2 (Dynein light intermediate chain 2, cytosolic).

SPON2_HUMAN
NC score	0.003197 (rank : 119)	θ value	8.99809 (rank : 128)
Query Neighborhood Hits	128	Target Neighborhood Hits	53	Shared Neighborhood Hits	2
SwissProt Accessions	Q9BUD6, Q9ULW1	Gene names	SPON2, DIL1
Domain Architecture	No domain graphic available
Description	Spondin-2 precursor (Mindin) (Differentially expressed in cancerous and non-cancerous lung cells 1) (DIL-1).

ZDHC8_HUMAN
NC score	0.003132 (rank : 120)	θ value	4.03905 (rank : 112)
Query Neighborhood Hits	128	Target Neighborhood Hits	234	Shared Neighborhood Hits	8
SwissProt Accessions	Q9ULC8, Q6ICL1, Q6ZNF5, Q7Z6L9	Gene names	ZDHHC8, KIAA1292, ZDHHCL1, ZNF378
Domain Architecture
Description	Probable palmitoyltransferase ZDHHC8 (EC 2.3.1.-) (Zinc finger DHHC domain-containing protein 8) (DHHC-8) (Zinc finger protein 378).

MUC1_HUMAN
NC score	0.001563 (rank : 121)	θ value	0.62314 (rank : 100)
Query Neighborhood Hits	128	Target Neighborhood Hits	975	Shared Neighborhood Hits	15
SwissProt Accessions	P15941, P13931, P15942, P17626, Q14128, Q14876, Q16437, Q16442, Q16615, Q9BXA4, Q9UE75, Q9UE76, Q9UQL1, Q9Y4J2	Gene names	MUC1
Domain Architecture
Description	Mucin-1 precursor (MUC-1) (Polymorphic epithelial mucin) (PEM) (PEMT) (Episialin) (Tumor-associated mucin) (Carcinoma-associated mucin) (Tumor-associated epithelial membrane antigen) (EMA) (H23AG) (Peanut- reactive urinary mucin) (PUM) (Breast carcinoma-associated antigen DF3) (CD227 antigen).

IRF4_MOUSE
NC score	0.001317 (rank : 122)	θ value	8.99809 (rank : 126)
Query Neighborhood Hits	128	Target Neighborhood Hits	27	Shared Neighborhood Hits	2
SwissProt Accessions	Q64287, Q60802	Gene names	Irf4, Spip
Domain Architecture
Description	Interferon regulatory factor 4 (IRF-4) (Lymphocyte-specific interferon regulatory factor) (LSIRF) (NF-EM5) (PU.1 interaction partner) (Transcriptional activator PIP).

BCAR1_HUMAN
NC score	0.001176 (rank : 123)	θ value	5.27518 (rank : 113)
Query Neighborhood Hits	128	Target Neighborhood Hits	554	Shared Neighborhood Hits	6
SwissProt Accessions	P56945	Gene names	BCAR1, CAS, CRKAS
Domain Architecture
Description	Breast cancer anti-estrogen resistance protein 1 (CRK-associated substrate) (p130cas).

CRIP3_HUMAN
NC score	0.000915 (rank : 124)	θ value	6.88961 (rank : 119)
Query Neighborhood Hits	128	Target Neighborhood Hits	104	Shared Neighborhood Hits	2
SwissProt Accessions	Q6Q6R5, Q5T043, Q6Q6R4, Q6Q6R6, Q6Q6R7	Gene names	CRIP3
Domain Architecture	No domain graphic available
Description	Cysteine-rich protein 3 (CRP3) (Chromosome 6 LIM-only protein) (h6LIMo).

MUC5B_HUMAN
NC score	-0.000282 (rank : 125)	θ value	8.99809 (rank : 127)
Query Neighborhood Hits	128	Target Neighborhood Hits	1020	Shared Neighborhood Hits	12
SwissProt Accessions	Q9HC84, O00447, O00573, O14985, O15494, O95291, O95451, Q14881, Q99552, Q9UE28	Gene names	MUC5B, MUC5
Domain Architecture
Description	Mucin-5B precursor (Mucin-5 subtype B, tracheobronchial) (High molecular weight salivary mucin MG1) (Sublingual gland mucin).

FOXO4_MOUSE
NC score	-0.000333 (rank : 126)	θ value	6.88961 (rank : 120)
Query Neighborhood Hits	128	Target Neighborhood Hits	168	Shared Neighborhood Hits	2
SwissProt Accessions	Q9WVH3	Gene names	Mllt7, Afx, Afx1, Fkhr3, Foxo4
Domain Architecture
Description	Fork head domain transcription factor AFX1 (Afxh) (Forkhead box protein O4).

PTN13_MOUSE
NC score	-0.002610 (rank : 127)	θ value	4.03905 (rank : 111)
Query Neighborhood Hits	128	Target Neighborhood Hits	426	Shared Neighborhood Hits	4
SwissProt Accessions	Q64512, Q61494, Q62135, Q64499	Gene names	Ptpn13, Ptp14
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 13 (EC 3.1.3.48) (Protein tyrosine phosphatase PTP-BL) (Protein-tyrosine phosphatase RIP) (protein tyrosine phosphatase DPZPTP) (PTP36).

SRRM2_MOUSE
NC score	-0.002787 (rank : 128)	θ value	6.88961 (rank : 122)
Query Neighborhood Hits	128	Target Neighborhood Hits	1470	Shared Neighborhood Hits	19
SwissProt Accessions	Q8BTI8, Q3TBY5, Q569P9, Q80U37, Q8K383	Gene names	Srrm2, Kiaa0324
Domain Architecture	No domain graphic available
Description	Serine/arginine repetitive matrix protein 2.

PGBM_MOUSE
NC score	-0.003150 (rank : 129)	θ value	0.813845 (rank : 101)
Query Neighborhood Hits	128	Target Neighborhood Hits	1073	Shared Neighborhood Hits	7
SwissProt Accessions	Q05793	Gene names	Hspg2
Domain Architecture
Description	Basement membrane-specific heparan sulfate proteoglycan core protein precursor (HSPG) (Perlecan) (PLC).

GAK_MOUSE
NC score	-0.005380 (rank : 130)	θ value	0.47712 (rank : 98)
Query Neighborhood Hits	128	Target Neighborhood Hits	964	Shared Neighborhood Hits	4
SwissProt Accessions	Q99KY4, Q6P1I8, Q6P9S5, Q8BM74, Q8K0Q4	Gene names	Gak
Domain Architecture	No domain graphic available
Description	Cyclin G-associated kinase (EC 2.7.11.1).

ZN516_HUMAN
NC score	-0.006168 (rank : 131)	θ value	1.81305 (rank : 105)
Query Neighborhood Hits	128	Target Neighborhood Hits	854	Shared Neighborhood Hits	4
SwissProt Accessions	Q92618	Gene names	ZNF516, KIAA0222
Domain Architecture	No domain graphic available
Description	Zinc finger protein 516.

CDKL5_HUMAN
NC score	-0.008925 (rank : 132)	θ value	8.99809 (rank : 124)
Query Neighborhood Hits	128	Target Neighborhood Hits	967	Shared Neighborhood Hits	4
SwissProt Accessions	O76039, Q14198, Q5H985, Q9UJL6	Gene names	CDKL5, STK9
Domain Architecture
Description	Cyclin-dependent kinase-like 5 (EC 2.7.11.22) (Serine/threonine- protein kinase 9).