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Network neighborhood for query Sequence : ERR1_HUMAN

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ERR1_HUMAN
SwissProt Accessions	P11474, Q14514	Gene names	ESRRA, ERR1, ESRL1, NR3B1
Domain Architecture
Description	Steroid hormone receptor ERR1 (Estrogen-related receptor, alpha) (ERR- alpha) (Estrogen receptor-like 1).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

ERR1_HUMAN
θ value	0 (rank : 1)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	157	Target Neighborhood Hits	157	Shared Neighborhood Hits	157
SwissProt Accessions	P11474, Q14514	Gene names	ESRRA, ERR1, ESRL1, NR3B1
Domain Architecture
Description	Steroid hormone receptor ERR1 (Estrogen-related receptor, alpha) (ERR- alpha) (Estrogen receptor-like 1).

ERR3_HUMAN
θ value	6.19918e-134 (rank : 2)	NC score	0.994135 (rank : 3)
Query Neighborhood Hits	157	Target Neighborhood Hits	106	Shared Neighborhood Hits	98
SwissProt Accessions	P62508, O75454, O96021, Q68DA0, Q6P274, Q6PK28, Q6TS38, Q9R1F3, Q9UNJ4	Gene names	ESRRG, ERR3, ERRG2, KIAA0832, NR3B3
Domain Architecture	No domain graphic available
Description	Estrogen-related receptor gamma (Estrogen receptor-related protein 3) (ERR gamma-2).

ERR3_MOUSE
θ value	6.19918e-134 (rank : 3)	NC score	0.994135 (rank : 4)
Query Neighborhood Hits	157	Target Neighborhood Hits	106	Shared Neighborhood Hits	98
SwissProt Accessions	P62509, O75454, O96021, Q8CHC9, Q9R1F3	Gene names	Esrrg, Err3, Kiaa0832, Nr3b3
Domain Architecture	No domain graphic available
Description	Estrogen-related receptor gamma (Estrogen receptor-related protein 3).

ERR2_HUMAN
θ value	4.30305e-127 (rank : 4)	NC score	0.994828 (rank : 2)
Query Neighborhood Hits	157	Target Neighborhood Hits	108	Shared Neighborhood Hits	98
SwissProt Accessions	O95718, Q9HCB4	Gene names	ESRRB, ERRB2, NR3B2
Domain Architecture
Description	Steroid hormone receptor ERR2 (Estrogen-related receptor, beta) (ERR- beta) (Estrogen receptor-like 2) (ERR beta-2).

ERR2_MOUSE
θ value	4.75757e-126 (rank : 5)	NC score	0.994109 (rank : 5)
Query Neighborhood Hits	157	Target Neighborhood Hits	109	Shared Neighborhood Hits	98
SwissProt Accessions	Q61539, O09067, O09146	Gene names	Esrrb, Err-2, Err2, Nr3b2
Domain Architecture
Description	Steroid hormone receptor ERR2 (Estrogen-related receptor, beta) (ERR- beta) (Estrogen receptor-like 2).

ESR2_HUMAN
θ value	3.25095e-58 (rank : 6)	NC score	0.976223 (rank : 6)
Query Neighborhood Hits	157	Target Neighborhood Hits	110	Shared Neighborhood Hits	98
SwissProt Accessions	Q92731, O60608, O60685, O60702, O60703, O75583, O75584, Q86Z31, Q9UEV6, Q9UHD3, Q9UQK9	Gene names	ESR2, ESTRB, NR3A2
Domain Architecture
Description	Estrogen receptor beta (ER-beta).

ESR2_MOUSE
θ value	3.974e-56 (rank : 7)	NC score	0.975803 (rank : 8)
Query Neighborhood Hits	157	Target Neighborhood Hits	110	Shared Neighborhood Hits	97
SwissProt Accessions	O08537, O35635, O70519	Gene names	Esr2, Estrb, Nr3a2
Domain Architecture
Description	Estrogen receptor beta (ER-beta).

ESR1_MOUSE
θ value	1.51013e-55 (rank : 8)	NC score	0.976219 (rank : 7)
Query Neighborhood Hits	157	Target Neighborhood Hits	104	Shared Neighborhood Hits	95
SwissProt Accessions	P19785, Q9JJT5, Q9QY51, Q9QY52	Gene names	Esr1, Esr, Estr, Estra, Nr3a1
Domain Architecture
Description	Estrogen receptor (ER) (Estradiol receptor) (ER-alpha).

ESR1_HUMAN
θ value	3.71957e-54 (rank : 9)	NC score	0.975264 (rank : 9)
Query Neighborhood Hits	157	Target Neighborhood Hits	105	Shared Neighborhood Hits	95
SwissProt Accessions	P03372, Q13511, Q14276, Q9NU51, Q9UDZ7, Q9UIS7	Gene names	ESR1, ESR, NR3A1
Domain Architecture
Description	Estrogen receptor (ER) (Estradiol receptor) (ER-alpha).

RXRA_HUMAN
θ value	1.19932e-44 (rank : 10)	NC score	0.956389 (rank : 14)
Query Neighborhood Hits	157	Target Neighborhood Hits	223	Shared Neighborhood Hits	104
SwissProt Accessions	P19793, Q2V504	Gene names	RXRA, NR2B1
Domain Architecture
Description	Retinoic acid receptor RXR-alpha (Retinoid X receptor alpha).

COT1_HUMAN
θ value	1.56636e-44 (rank : 11)	NC score	0.952093 (rank : 28)
Query Neighborhood Hits	157	Target Neighborhood Hits	159	Shared Neighborhood Hits	101
SwissProt Accessions	P10589	Gene names	NR2F1, EAR3, ERBAL3, TFCOUP1
Domain Architecture
Description	COUP transcription factor 1 (COUP-TF1) (COUP-TF I) (V-ERBA-related protein EAR-3).

COT1_MOUSE
θ value	1.56636e-44 (rank : 12)	NC score	0.952375 (rank : 27)
Query Neighborhood Hits	157	Target Neighborhood Hits	160	Shared Neighborhood Hits	100
SwissProt Accessions	Q60632, Q61438	Gene names	Nr2f1, Erbal3, Tfcoup1
Domain Architecture
Description	COUP transcription factor 1 (COUP-TF1) (COUP-TF I).

COT2_HUMAN
θ value	1.73182e-43 (rank : 13)	NC score	0.953815 (rank : 24)
Query Neighborhood Hits	157	Target Neighborhood Hits	135	Shared Neighborhood Hits	102
SwissProt Accessions	P24468, Q03754	Gene names	NR2F2, ARP1, TFCOUP2
Domain Architecture
Description	COUP transcription factor 2 (COUP-TF2) (COUP-TF II) (Apolipoprotein AI regulatory protein 1) (ARP-1).

COT2_MOUSE
θ value	1.73182e-43 (rank : 14)	NC score	0.953815 (rank : 25)
Query Neighborhood Hits	157	Target Neighborhood Hits	135	Shared Neighborhood Hits	102
SwissProt Accessions	P43135	Gene names	Nr2f2, Aporp1, Arp-1, Arp1, Tfcoup2
Domain Architecture
Description	COUP transcription factor 2 (COUP-TF2) (COUP-TF II) (Apolipoprotein AI regulatory protein 1) (ARP-1).

RXRA_MOUSE
θ value	1.73182e-43 (rank : 15)	NC score	0.959022 (rank : 12)
Query Neighborhood Hits	157	Target Neighborhood Hits	129	Shared Neighborhood Hits	99
SwissProt Accessions	P28700	Gene names	Rxra, Nr2b1
Domain Architecture
Description	Retinoic acid receptor RXR-alpha (Retinoid X receptor alpha).

GCR_HUMAN
θ value	8.04462e-41 (rank : 16)	NC score	0.936292 (rank : 45)
Query Neighborhood Hits	157	Target Neighborhood Hits	113	Shared Neighborhood Hits	94
SwissProt Accessions	P04150, P04151, Q53EP5, Q6N0A4	Gene names	NR3C1, GRL
Domain Architecture
Description	Glucocorticoid receptor (GR).

PRGR_MOUSE
θ value	6.81017e-40 (rank : 17)	NC score	0.923131 (rank : 65)
Query Neighborhood Hits	157	Target Neighborhood Hits	286	Shared Neighborhood Hits	108
SwissProt Accessions	Q00175	Gene names	Pgr, Nr3c3, Pr
Domain Architecture
Description	Progesterone receptor (PR).

PRGR_HUMAN
θ value	8.89434e-40 (rank : 18)	NC score	0.929637 (rank : 50)
Query Neighborhood Hits	157	Target Neighborhood Hits	163	Shared Neighborhood Hits	99
SwissProt Accessions	P06401, Q9UPF7	Gene names	PGR, NR3C3
Domain Architecture
Description	Progesterone receptor (PR).

RXRB_HUMAN
θ value	1.98146e-39 (rank : 19)	NC score	0.952794 (rank : 26)
Query Neighborhood Hits	157	Target Neighborhood Hits	280	Shared Neighborhood Hits	107
SwissProt Accessions	P28702, P28703	Gene names	RXRB, NR2B2
Domain Architecture
Description	Retinoic acid receptor RXR-beta (Retinoid X receptor beta).

RXRB_MOUSE
θ value	2.58786e-39 (rank : 20)	NC score	0.955297 (rank : 21)
Query Neighborhood Hits	157	Target Neighborhood Hits	230	Shared Neighborhood Hits	101
SwissProt Accessions	P28704, P33243	Gene names	Rxrb, Nr2b2
Domain Architecture
Description	Retinoic acid receptor RXR-beta (Retinoid X receptor beta) (MHC class I regulatory element-binding protein H-2RIIBP).

GCR_MOUSE
θ value	7.52953e-39 (rank : 21)	NC score	0.932065 (rank : 49)
Query Neighborhood Hits	157	Target Neighborhood Hits	117	Shared Neighborhood Hits	94
SwissProt Accessions	P06537, Q61628, Q61629	Gene names	Nr3c1, Grl, Grl1
Domain Architecture
Description	Glucocorticoid receptor (GR).

EAR2_MOUSE
θ value	1.28434e-38 (rank : 22)	NC score	0.955762 (rank : 19)
Query Neighborhood Hits	157	Target Neighborhood Hits	104	Shared Neighborhood Hits	98
SwissProt Accessions	P43136, Q61504	Gene names	Nr2f6, Ear-2, Ear2, Erbal2
Domain Architecture
Description	Orphan nuclear receptor EAR-2 (V-erbA-related protein EAR-2).

RXRG_HUMAN
θ value	1.6774e-38 (rank : 23)	NC score	0.959095 (rank : 11)
Query Neighborhood Hits	157	Target Neighborhood Hits	114	Shared Neighborhood Hits	99
SwissProt Accessions	P48443	Gene names	RXRG, NR2B3
Domain Architecture
Description	Retinoic acid receptor RXR-gamma (Retinoid X receptor gamma).

RARA_HUMAN
θ value	8.32485e-38 (rank : 24)	NC score	0.942827 (rank : 41)
Query Neighborhood Hits	157	Target Neighborhood Hits	118	Shared Neighborhood Hits	96
SwissProt Accessions	P10276, P78456, Q13440, Q13441, Q9NQS0	Gene names	RARA, NR1B1
Domain Architecture
Description	Retinoic acid receptor alpha (RAR-alpha).

RXRG_MOUSE
θ value	8.32485e-38 (rank : 25)	NC score	0.959615 (rank : 10)
Query Neighborhood Hits	157	Target Neighborhood Hits	113	Shared Neighborhood Hits	98
SwissProt Accessions	P28705	Gene names	Rxrg, Nr2b3
Domain Architecture
Description	Retinoic acid receptor RXR-gamma (Retinoid X receptor gamma).

NR4A2_HUMAN
θ value	1.08726e-37 (rank : 26)	NC score	0.951427 (rank : 30)
Query Neighborhood Hits	157	Target Neighborhood Hits	120	Shared Neighborhood Hits	94
SwissProt Accessions	P43354, Q16311	Gene names	NR4A2, NOT, NURR1, TINUR
Domain Architecture
Description	Orphan nuclear receptor NR4A2 (Orphan nuclear receptor NURR1) (Immediate-early response protein NOT) (Transcriptionally-inducible nuclear receptor).

NR4A2_MOUSE
θ value	1.08726e-37 (rank : 27)	NC score	0.951376 (rank : 31)
Query Neighborhood Hits	157	Target Neighborhood Hits	121	Shared Neighborhood Hits	94
SwissProt Accessions	Q06219, O08690	Gene names	Nr4a2, Nurr1
Domain Architecture
Description	Orphan nuclear receptor NR4A2 (Orphan nuclear receptor NURR1) (NUR- related factor 1).

NR4A3_MOUSE
θ value	1.08726e-37 (rank : 28)	NC score	0.951110 (rank : 33)
Query Neighborhood Hits	157	Target Neighborhood Hits	127	Shared Neighborhood Hits	95
SwissProt Accessions	Q9QZB6, Q9QZB5	Gene names	Nr4a3, Tec
Domain Architecture
Description	Orphan nuclear receptor NR4A3 (Orphan nuclear receptor TEC) (Translocated in extraskeletal chondrosarcoma).

RARA_MOUSE
θ value	1.08726e-37 (rank : 29)	NC score	0.942914 (rank : 40)
Query Neighborhood Hits	157	Target Neighborhood Hits	113	Shared Neighborhood Hits	96
SwissProt Accessions	P11416, P22603	Gene names	Rara, Nr1b1
Domain Architecture
Description	Retinoic acid receptor alpha (RAR-alpha).

HNF4A_HUMAN
θ value	5.39604e-37 (rank : 30)	NC score	0.955126 (rank : 23)
Query Neighborhood Hits	157	Target Neighborhood Hits	105	Shared Neighborhood Hits	98
SwissProt Accessions	P41235, O00659, O00723, Q14540, Q92653, Q92654, Q92655, Q99864, Q9NQH0	Gene names	HNF4A, HNF4, NR2A1, TCF14
Domain Architecture
Description	Hepatocyte nuclear factor 4-alpha (HNF-4-alpha) (Transcription factor HNF-4) (Transcription factor 14).

RARG1_MOUSE
θ value	5.39604e-37 (rank : 31)	NC score	0.944129 (rank : 39)
Query Neighborhood Hits	157	Target Neighborhood Hits	113	Shared Neighborhood Hits	96
SwissProt Accessions	P18911, Q91VK5	Gene names	Rarg, Nr1b3
Domain Architecture
Description	Retinoic acid receptor gamma-A (RAR-gamma-A).

RARG2_MOUSE
θ value	5.39604e-37 (rank : 32)	NC score	0.944223 (rank : 38)
Query Neighborhood Hits	157	Target Neighborhood Hits	114	Shared Neighborhood Hits	96
SwissProt Accessions	P20787	Gene names	Rarg, Nr1b3
Domain Architecture
Description	Retinoic acid receptor gamma-B (RAR-gamma-B).

NR4A3_HUMAN
θ value	9.20422e-37 (rank : 33)	NC score	0.951056 (rank : 34)
Query Neighborhood Hits	157	Target Neighborhood Hits	131	Shared Neighborhood Hits	96
SwissProt Accessions	Q92570, Q12935, Q14979, Q16420, Q4VXA9, Q9UEK2, Q9UEK3	Gene names	NR4A3, CHN, CSMF, MINOR, NOR1, TEC
Domain Architecture
Description	Orphan nuclear receptor NR4A3 (Nuclear hormone receptor NOR-1) (Neuron-derived orphan receptor 1) (Mitogen-induced nuclear orphan receptor).

RARB_HUMAN
θ value	9.20422e-37 (rank : 34)	NC score	0.942591 (rank : 42)
Query Neighborhood Hits	157	Target Neighborhood Hits	118	Shared Neighborhood Hits	94
SwissProt Accessions	P10826, P12891, Q00989, Q15298, Q9UN48	Gene names	RARB, HAP, NR1B2
Domain Architecture
Description	Retinoic acid receptor beta (RAR-beta) (RAR-epsilon) (HBV-activated protein).

RARB_MOUSE
θ value	9.20422e-37 (rank : 35)	NC score	0.942200 (rank : 43)
Query Neighborhood Hits	157	Target Neighborhood Hits	109	Shared Neighborhood Hits	94
SwissProt Accessions	P22605, P11417, P22604	Gene names	Rarb, Nr1b2
Domain Architecture
Description	Retinoic acid receptor beta (RAR-beta).

RARG1_HUMAN
θ value	3.4976e-36 (rank : 36)	NC score	0.944697 (rank : 36)
Query Neighborhood Hits	157	Target Neighborhood Hits	107	Shared Neighborhood Hits	95
SwissProt Accessions	P13631	Gene names	RARG, NR1B3
Domain Architecture
Description	Retinoic acid receptor gamma-1 (RAR-gamma-1).

RARG2_HUMAN
θ value	3.4976e-36 (rank : 37)	NC score	0.944602 (rank : 37)
Query Neighborhood Hits	157	Target Neighborhood Hits	109	Shared Neighborhood Hits	95
SwissProt Accessions	P22932, Q15281	Gene names	RARG, NR1B3
Domain Architecture	No domain graphic available
Description	Retinoic acid receptor gamma-2 (RAR-gamma-2).

MCR_HUMAN
θ value	4.568e-36 (rank : 38)	NC score	0.927724 (rank : 55)
Query Neighborhood Hits	157	Target Neighborhood Hits	149	Shared Neighborhood Hits	96
SwissProt Accessions	P08235, Q96KQ8, Q96KQ9	Gene names	NR3C2, MCR, MLR
Domain Architecture
Description	Mineralocorticoid receptor (MR).

HNF4G_HUMAN
θ value	2.26708e-35 (rank : 39)	NC score	0.956091 (rank : 16)
Query Neighborhood Hits	157	Target Neighborhood Hits	100	Shared Neighborhood Hits	98
SwissProt Accessions	Q14541, Q9UH81, Q9UIS6	Gene names	HNF4G, NR2A2
Domain Architecture
Description	Hepatocyte nuclear factor 4-gamma (HNF-4-gamma).

HNF4G_MOUSE
θ value	6.59618e-35 (rank : 40)	NC score	0.956270 (rank : 15)
Query Neighborhood Hits	157	Target Neighborhood Hits	101	Shared Neighborhood Hits	98
SwissProt Accessions	Q9WUU6	Gene names	Hnf4g, Nr2a2
Domain Architecture
Description	Hepatocyte nuclear factor 4-gamma (HNF-4-gamma).

NR4A1_HUMAN
θ value	6.59618e-35 (rank : 41)	NC score	0.951338 (rank : 32)
Query Neighborhood Hits	157	Target Neighborhood Hits	133	Shared Neighborhood Hits	98
SwissProt Accessions	P22736	Gene names	NR4A1, GFRP1, HMR, NAK1
Domain Architecture
Description	Orphan nuclear receptor NR4A1 (Orphan nuclear receptor HMR) (Early response protein NAK1) (TR3 orphan receptor) (ST-59).

HNF4A_MOUSE
θ value	8.61488e-35 (rank : 42)	NC score	0.955177 (rank : 22)
Query Neighborhood Hits	157	Target Neighborhood Hits	103	Shared Neighborhood Hits	98
SwissProt Accessions	P49698	Gene names	Hnf4a, Hnf-4, Hnf4, Nr2a1, Tcf14
Domain Architecture
Description	Hepatocyte nuclear factor 4-alpha (HNF-4-alpha) (Transcription factor HNF-4) (Transcription factor 14).

ANDR_MOUSE
θ value	1.46948e-34 (rank : 43)	NC score	0.928777 (rank : 53)
Query Neighborhood Hits	157	Target Neighborhood Hits	133	Shared Neighborhood Hits	94
SwissProt Accessions	P19091	Gene names	Ar, Nr3c4
Domain Architecture
Description	Androgen receptor (Dihydrotestosterone receptor).

NR2E3_MOUSE
θ value	5.584e-34 (rank : 44)	NC score	0.955362 (rank : 20)
Query Neighborhood Hits	157	Target Neighborhood Hits	113	Shared Neighborhood Hits	98
SwissProt Accessions	Q9QXZ7	Gene names	Nr2e3, Pnr, Rnr
Domain Architecture
Description	Photoreceptor-specific nuclear receptor (Retina-specific nuclear receptor).

MCR_MOUSE
θ value	7.29293e-34 (rank : 45)	NC score	0.924711 (rank : 62)
Query Neighborhood Hits	157	Target Neighborhood Hits	162	Shared Neighborhood Hits	95
SwissProt Accessions	Q8VII8, Q8VII9	Gene names	Nr3c2, Mlr
Domain Architecture	No domain graphic available
Description	Mineralocorticoid receptor (MR).

NR4A1_MOUSE
θ value	1.6247e-33 (rank : 46)	NC score	0.950194 (rank : 35)
Query Neighborhood Hits	157	Target Neighborhood Hits	128	Shared Neighborhood Hits	94
SwissProt Accessions	P12813	Gene names	Nr4a1, Gfrp, Hmr, N10, Nur77
Domain Architecture
Description	Orphan nuclear receptor NR4A1 (Orphan nuclear receptor HMR) (Nuclear hormone receptor NUR/77) (N10 nuclear protein).

EAR2_HUMAN
θ value	8.06329e-33 (rank : 47)	NC score	0.955842 (rank : 18)
Query Neighborhood Hits	157	Target Neighborhood Hits	106	Shared Neighborhood Hits	98
SwissProt Accessions	P10588, Q9BUE8	Gene names	NR2F6, EAR2, ERBAL2
Domain Architecture
Description	Orphan nuclear receptor EAR-2 (V-erbA-related protein EAR-2).

ANDR_HUMAN
θ value	1.0531e-32 (rank : 48)	NC score	0.928179 (rank : 54)
Query Neighborhood Hits	157	Target Neighborhood Hits	126	Shared Neighborhood Hits	94
SwissProt Accessions	P10275	Gene names	AR, DHTR, NR3C4
Domain Architecture
Description	Androgen receptor (Dihydrotestosterone receptor).

NR2E1_MOUSE
θ value	2.34606e-32 (rank : 49)	NC score	0.957050 (rank : 13)
Query Neighborhood Hits	157	Target Neighborhood Hits	106	Shared Neighborhood Hits	98
SwissProt Accessions	Q64104	Gene names	Nr2e1, Tll, Tlx
Domain Architecture
Description	Orphan nuclear receptor NR2E1 (Nuclear receptor TLX) (Tailless homolog) (Tll) (mTll).

THA_MOUSE
θ value	4.00176e-32 (rank : 50)	NC score	0.924881 (rank : 60)
Query Neighborhood Hits	157	Target Neighborhood Hits	113	Shared Neighborhood Hits	98
SwissProt Accessions	P63058, P10685, P15827, P16416, P37241, Q63107, Q63195, Q63196, Q99146	Gene names	Thra, C-erba-alpha, Nr1a1
Domain Architecture	No domain graphic available
Description	Thyroid hormone receptor alpha (C-erbA-alpha) (c-erbA-1).

THA_HUMAN
θ value	5.22648e-32 (rank : 51)	NC score	0.924964 (rank : 59)
Query Neighborhood Hits	157	Target Neighborhood Hits	113	Shared Neighborhood Hits	98
SwissProt Accessions	P10827, P21205, Q8N6A1, Q96H73	Gene names	THRA, ERBA1, NR1A1, THRA1
Domain Architecture
Description	Thyroid hormone receptor alpha (C-erbA-alpha) (c-erbA-1) (EAR-7) (EAR7).

NR2E3_HUMAN
θ value	6.82597e-32 (rank : 52)	NC score	0.951840 (rank : 29)
Query Neighborhood Hits	157	Target Neighborhood Hits	102	Shared Neighborhood Hits	98
SwissProt Accessions	Q9Y5X4, Q9UHM4	Gene names	NR2E3, PNR, RNR
Domain Architecture
Description	Photoreceptor-specific nuclear receptor (Retina-specific nuclear receptor).

NR1H3_HUMAN
θ value	5.77852e-31 (rank : 53)	NC score	0.934162 (rank : 47)
Query Neighborhood Hits	157	Target Neighborhood Hits	104	Shared Neighborhood Hits	96
SwissProt Accessions	Q13133, Q96H87	Gene names	NR1H3, LXRA
Domain Architecture
Description	Oxysterols receptor LXR-alpha (Liver X receptor alpha) (Nuclear orphan receptor LXR-alpha).

NR1H3_MOUSE
θ value	3.74554e-30 (rank : 54)	NC score	0.933540 (rank : 48)
Query Neighborhood Hits	157	Target Neighborhood Hits	102	Shared Neighborhood Hits	94
SwissProt Accessions	Q9Z0Y9, Q9QUH7	Gene names	Nr1h3, Lxra
Domain Architecture
Description	Oxysterols receptor LXR-alpha (Liver X receptor alpha) (Nuclear orphan receptor LXR-alpha).

NR2E1_HUMAN
θ value	6.38894e-30 (rank : 55)	NC score	0.955991 (rank : 17)
Query Neighborhood Hits	157	Target Neighborhood Hits	103	Shared Neighborhood Hits	98
SwissProt Accessions	Q9Y466	Gene names	NR2E1, TLX
Domain Architecture
Description	Orphan nuclear receptor NR2E1 (Nuclear receptor TLX) (Tailless homolog) (Tll) (hTll).

NR1I3_MOUSE
θ value	5.97985e-28 (rank : 56)	NC score	0.936553 (rank : 44)
Query Neighborhood Hits	157	Target Neighborhood Hits	103	Shared Neighborhood Hits	98
SwissProt Accessions	O35627, O35628	Gene names	Nr1i3, Car
Domain Architecture
Description	Orphan nuclear receptor NR1I3 (Constitutive androstane receptor) (CAR) (Orphan nuclear receptor MB67).

VDR_MOUSE
θ value	1.73987e-27 (rank : 57)	NC score	0.915415 (rank : 72)
Query Neighborhood Hits	157	Target Neighborhood Hits	103	Shared Neighborhood Hits	96
SwissProt Accessions	P48281	Gene names	Vdr, Nr1i1
Domain Architecture
Description	Vitamin D3 receptor (VDR) (1,25-dihydroxyvitamin D3 receptor).

THB1_MOUSE
θ value	1.47289e-26 (rank : 58)	NC score	0.915646 (rank : 70)
Query Neighborhood Hits	157	Target Neighborhood Hits	105	Shared Neighborhood Hits	98
SwissProt Accessions	P37242	Gene names	Thrb, C-erba-beta, Nr1a2
Domain Architecture
Description	Thyroid hormone receptor beta-1.

THB2_MOUSE
θ value	1.47289e-26 (rank : 59)	NC score	0.915469 (rank : 71)
Query Neighborhood Hits	157	Target Neighborhood Hits	106	Shared Neighborhood Hits	98
SwissProt Accessions	P37244	Gene names	Thrb, C-erba-beta, Nr1a2
Domain Architecture
Description	Thyroid hormone receptor beta-2.

THB1_HUMAN
θ value	1.92365e-26 (rank : 60)	NC score	0.916527 (rank : 69)
Query Neighborhood Hits	157	Target Neighborhood Hits	106	Shared Neighborhood Hits	98
SwissProt Accessions	P10828, Q13986	Gene names	THRB, ERBA2, NR1A2, THR1
Domain Architecture
Description	Thyroid hormone receptor beta-1.

THB2_HUMAN
θ value	2.51237e-26 (rank : 61)	NC score	0.917352 (rank : 68)
Query Neighborhood Hits	157	Target Neighborhood Hits	104	Shared Neighborhood Hits	98
SwissProt Accessions	P37243	Gene names	THRB, ERBA2, NR1A2, THR1
Domain Architecture	No domain graphic available
Description	Thyroid hormone receptor beta-2.

STF1_HUMAN
θ value	5.59698e-26 (rank : 62)	NC score	0.929223 (rank : 51)
Query Neighborhood Hits	157	Target Neighborhood Hits	132	Shared Neighborhood Hits	99
SwissProt Accessions	Q13285, O15196	Gene names	NR5A1, AD4BP, FTZF1, SF1
Domain Architecture
Description	Steroidogenic factor 1 (STF-1) (SF-1) (Adrenal 4-binding protein) (Steroid hormone receptor Ad4BP) (Fushi tarazu factor homolog 1).

STF1_MOUSE
θ value	1.24688e-25 (rank : 63)	NC score	0.929055 (rank : 52)
Query Neighborhood Hits	157	Target Neighborhood Hits	137	Shared Neighborhood Hits	98
SwissProt Accessions	P33242	Gene names	Nr5a1, Ftzf1
Domain Architecture
Description	Steroidogenic factor 1 (STF-1) (SF-1) (Adrenal 4-binding protein) (Steroid hormone receptor Ad4BP) (Fushi tarazu factor homolog 1) (Embryonal LTR-binding protein) (ELP) (Embryonal long terminal repeat- binding protein) (Steroid hydroxylase positive regulator).

NR5A2_HUMAN
θ value	2.77775e-25 (rank : 64)	NC score	0.921872 (rank : 66)
Query Neighborhood Hits	157	Target Neighborhood Hits	112	Shared Neighborhood Hits	98
SwissProt Accessions	O00482, O95642	Gene names	NR5A2, B1F, CPF, FTF
Domain Architecture
Description	Orphan nuclear receptor NR5A2 (Alpha-1-fetoprotein transcription factor) (Hepatocytic transcription factor) (B1-binding factor) (hB1F) (CYP7A promoter-binding factor) (Liver receptor homolog 1) (LRH-1).

NR5A2_MOUSE
θ value	6.18819e-25 (rank : 65)	NC score	0.923943 (rank : 64)
Query Neighborhood Hits	157	Target Neighborhood Hits	107	Shared Neighborhood Hits	98
SwissProt Accessions	P45448	Gene names	Nr5a2, Lrh1
Domain Architecture
Description	Orphan nuclear receptor NR5A2 (Liver receptor homolog 1) (LRH-1).

PXR_MOUSE
θ value	1.5242e-23 (rank : 66)	NC score	0.912377 (rank : 75)
Query Neighborhood Hits	157	Target Neighborhood Hits	107	Shared Neighborhood Hits	97
SwissProt Accessions	O54915	Gene names	Nr1i2, Pxr
Domain Architecture
Description	Orphan nuclear receptor PXR (Pregnane X receptor).

PXR_HUMAN
θ value	9.24701e-21 (rank : 67)	NC score	0.907601 (rank : 77)
Query Neighborhood Hits	157	Target Neighborhood Hits	107	Shared Neighborhood Hits	97
SwissProt Accessions	O75469, Q96AC7, Q9UJ22, Q9UJ23, Q9UJ24, Q9UJ25, Q9UJ26, Q9UJ27	Gene names	NR1I2, PXR
Domain Architecture
Description	Orphan nuclear receptor PXR (Pregnane X receptor) (Orphan nuclear receptor PAR1) (Steroid and xenobiotic receptor) (SXR).

NR1I3_HUMAN
θ value	1.2077e-20 (rank : 68)	NC score	0.936203 (rank : 46)
Query Neighborhood Hits	157	Target Neighborhood Hits	107	Shared Neighborhood Hits	98
SwissProt Accessions	Q14994	Gene names	NR1I3, CAR
Domain Architecture
Description	Orphan nuclear receptor NR1I3 (Constitutive androstane receptor) (CAR) (Constitutive activator of retinoid response) (Constitutive active response) (Orphan nuclear receptor MB67).

NR6A1_HUMAN
θ value	1.2077e-20 (rank : 69)	NC score	0.926224 (rank : 57)
Query Neighborhood Hits	157	Target Neighborhood Hits	108	Shared Neighborhood Hits	98
SwissProt Accessions	Q15406, O00551, O00603, Q8NHQ0, Q92898, Q99802	Gene names	NR6A1, GCNF
Domain Architecture
Description	Orphan nuclear receptor NR6A1 (Germ cell nuclear factor) (GCNF) (Retinoid receptor-related testis-specific receptor) (RTR).

NR1D2_HUMAN
θ value	2.06002e-20 (rank : 70)	NC score	0.906753 (rank : 78)
Query Neighborhood Hits	157	Target Neighborhood Hits	115	Shared Neighborhood Hits	94
SwissProt Accessions	Q14995, O00402, Q86XD4	Gene names	NR1D2
Domain Architecture
Description	Orphan nuclear receptor NR1D2 (Rev-erb-beta) (EAR-1R) (Orphan nuclear hormone receptor BD73).

NR1D2_MOUSE
θ value	2.06002e-20 (rank : 71)	NC score	0.903720 (rank : 82)
Query Neighborhood Hits	157	Target Neighborhood Hits	109	Shared Neighborhood Hits	94
SwissProt Accessions	Q60674, Q60646	Gene names	Nr1d2
Domain Architecture
Description	Orphan nuclear receptor NR1D2 (Rev-erb-beta) (Orphan nuclear receptor RVR).

NR1D1_HUMAN
θ value	2.69047e-20 (rank : 72)	NC score	0.912808 (rank : 74)
Query Neighborhood Hits	157	Target Neighborhood Hits	140	Shared Neighborhood Hits	96
SwissProt Accessions	P20393, Q15304	Gene names	NR1D1, EAR1, HREV, THRAL
Domain Architecture
Description	Orphan nuclear receptor NR1D1 (V-erbA-related protein EAR-1) (Rev- erbA-alpha).

NR6A1_MOUSE
θ value	2.69047e-20 (rank : 73)	NC score	0.926121 (rank : 58)
Query Neighborhood Hits	157	Target Neighborhood Hits	110	Shared Neighborhood Hits	98
SwissProt Accessions	Q64249	Gene names	Nr6a1, Gcnf
Domain Architecture
Description	Orphan nuclear receptor NR6A1 (Germ cell nuclear factor) (GCNF) (Retinoid receptor-related testis-specific receptor) (RTR).

TR4_MOUSE
θ value	1.33526e-19 (rank : 74)	NC score	0.904415 (rank : 81)
Query Neighborhood Hits	157	Target Neighborhood Hits	115	Shared Neighborhood Hits	99
SwissProt Accessions	P49117, P55093	Gene names	Nr2c2, Mtr2r1, Tak1, Tr4
Domain Architecture
Description	Orphan nuclear receptor TR4 (Orphan nuclear receptor TAK1).

TR4_HUMAN
θ value	2.97466e-19 (rank : 75)	NC score	0.904598 (rank : 80)
Query Neighborhood Hits	157	Target Neighborhood Hits	117	Shared Neighborhood Hits	99
SwissProt Accessions	P49116, P55092	Gene names	NR2C2, TAK1, TR4
Domain Architecture
Description	Orphan nuclear receptor TR4 (Orphan nuclear receptor TAK1).

NR1H2_MOUSE
θ value	5.07402e-19 (rank : 76)	NC score	0.924216 (rank : 63)
Query Neighborhood Hits	157	Target Neighborhood Hits	109	Shared Neighborhood Hits	96
SwissProt Accessions	Q60644	Gene names	Nr1h2, Lxrb, Rip15, Unr, Unr2
Domain Architecture
Description	Oxysterols receptor LXR-beta (Liver X receptor beta) (Nuclear orphan receptor LXR-beta) (Ubiquitously-expressed nuclear receptor) (Retinoid X receptor-interacting protein No.15).

TR2_HUMAN
θ value	1.13037e-18 (rank : 77)	NC score	0.914669 (rank : 73)
Query Neighborhood Hits	157	Target Neighborhood Hits	110	Shared Neighborhood Hits	97
SwissProt Accessions	P13056	Gene names	NR2C1, TR2
Domain Architecture
Description	Orphan nuclear receptor TR2 (Testicular receptor 2).

TR2_MOUSE
θ value	1.13037e-18 (rank : 78)	NC score	0.905784 (rank : 79)
Query Neighborhood Hits	157	Target Neighborhood Hits	100	Shared Neighborhood Hits	98
SwissProt Accessions	Q505F1, P97763, Q3UIJ7, Q4U1Z4, Q60927, Q62152, Q8VIJ3	Gene names	Nr2c1, Tr2, Tr2-11
Domain Architecture	No domain graphic available
Description	Orphan nuclear receptor TR2 (Testicular receptor 2) (mTR2).

VDR_HUMAN
θ value	1.92812e-18 (rank : 79)	NC score	0.910693 (rank : 76)
Query Neighborhood Hits	157	Target Neighborhood Hits	112	Shared Neighborhood Hits	96
SwissProt Accessions	P11473	Gene names	VDR, NR1I1
Domain Architecture
Description	Vitamin D3 receptor (VDR) (1,25-dihydroxyvitamin D3 receptor).

PPARA_MOUSE
θ value	3.28887e-18 (rank : 80)	NC score	0.903166 (rank : 83)
Query Neighborhood Hits	157	Target Neighborhood Hits	99	Shared Neighborhood Hits	95
SwissProt Accessions	P23204	Gene names	Ppara, Nr1c1, Ppar
Domain Architecture
Description	Peroxisome proliferator-activated receptor alpha (PPAR-alpha).

PPARG_HUMAN
θ value	5.60996e-18 (rank : 81)	NC score	0.900364 (rank : 85)
Query Neighborhood Hits	157	Target Neighborhood Hits	97	Shared Neighborhood Hits	94
SwissProt Accessions	P37231, O00684, O00710, O14515, Q15178, Q15179, Q15180, Q15832, Q86U60, Q96J12	Gene names	PPARG, NR1C3
Domain Architecture
Description	Peroxisome proliferator-activated receptor gamma (PPAR-gamma).

RORA_HUMAN
θ value	5.60996e-18 (rank : 82)	NC score	0.893062 (rank : 90)
Query Neighborhood Hits	157	Target Neighborhood Hits	105	Shared Neighborhood Hits	94
SwissProt Accessions	P35398, P35397, P35399, P45445, Q96H83	Gene names	RORA, NR1F1, RZRA
Domain Architecture
Description	Nuclear receptor ROR-alpha (Nuclear receptor RZR-alpha).

RORA_MOUSE
θ value	5.60996e-18 (rank : 83)	NC score	0.891736 (rank : 93)
Query Neighborhood Hits	157	Target Neighborhood Hits	105	Shared Neighborhood Hits	94
SwissProt Accessions	P51448, P70283, P97741, P97773, Q923G1	Gene names	Rora, Nr1f1, Rzra
Domain Architecture
Description	Nuclear receptor ROR-alpha (Nuclear receptor RZR-alpha).

RORB_HUMAN
θ value	7.32683e-18 (rank : 84)	NC score	0.892429 (rank : 92)
Query Neighborhood Hits	157	Target Neighborhood Hits	99	Shared Neighborhood Hits	94
SwissProt Accessions	Q92753, Q8WX73	Gene names	RORB, NR1F2, RZRB
Domain Architecture
Description	Nuclear receptor ROR-beta (Nuclear receptor RZR-beta).

RORB_MOUSE
θ value	7.32683e-18 (rank : 85)	NC score	0.892691 (rank : 91)
Query Neighborhood Hits	157	Target Neighborhood Hits	99	Shared Neighborhood Hits	94
SwissProt Accessions	Q8R1B8	Gene names	Rorb, Nr1f2
Domain Architecture
Description	Nuclear receptor ROR-beta (Nuclear receptor RZR-beta).

PPARD_HUMAN
θ value	9.56915e-18 (rank : 86)	NC score	0.899875 (rank : 87)
Query Neighborhood Hits	157	Target Neighborhood Hits	102	Shared Neighborhood Hits	94
SwissProt Accessions	Q03181, Q7Z5K0, Q9BUD4	Gene names	PPARD, NR1C2, PPARB
Domain Architecture
Description	Peroxisome proliferator-activated receptor delta (PPAR-delta) (PPAR- beta) (Nuclear hormone receptor 1) (NUC1) (NUCI).

PPARA_HUMAN
θ value	1.63225e-17 (rank : 87)	NC score	0.902971 (rank : 84)
Query Neighborhood Hits	157	Target Neighborhood Hits	100	Shared Neighborhood Hits	94
SwissProt Accessions	Q07869, Q16241, Q92486, Q92689, Q9Y3N1	Gene names	PPARA, NR1C1, PPAR
Domain Architecture
Description	Peroxisome proliferator-activated receptor alpha (PPAR-alpha).

PPARD_MOUSE
θ value	2.13179e-17 (rank : 88)	NC score	0.897459 (rank : 88)
Query Neighborhood Hits	157	Target Neighborhood Hits	103	Shared Neighborhood Hits	95
SwissProt Accessions	P35396, P37239	Gene names	Ppard, Nr1c2, Pparb
Domain Architecture
Description	Peroxisome proliferator-activated receptor delta (PPAR-delta) (PPAR- beta) (Nuclear hormone receptor 1) (NUC1).

NR1H2_HUMAN
θ value	2.7842e-17 (rank : 89)	NC score	0.917791 (rank : 67)
Query Neighborhood Hits	157	Target Neighborhood Hits	114	Shared Neighborhood Hits	96
SwissProt Accessions	P55055, Q12970	Gene names	NR1H2, LXRB, NER, UNR
Domain Architecture
Description	Oxysterols receptor LXR-beta (Liver X receptor beta) (Nuclear orphan receptor LXR-beta) (Ubiquitously-expressed nuclear receptor) (Nuclear receptor NER).

PPARG_MOUSE
θ value	2.7842e-17 (rank : 90)	NC score	0.899933 (rank : 86)
Query Neighborhood Hits	157	Target Neighborhood Hits	97	Shared Neighborhood Hits	94
SwissProt Accessions	P37238	Gene names	Pparg, Nr1c3
Domain Architecture
Description	Peroxisome proliferator-activated receptor gamma (PPAR-gamma).

RORG_MOUSE
θ value	4.74913e-17 (rank : 91)	NC score	0.893241 (rank : 89)
Query Neighborhood Hits	157	Target Neighborhood Hits	107	Shared Neighborhood Hits	94
SwissProt Accessions	P51450, Q61027, Q91YT5, Q9QXD9, Q9R177	Gene names	Rorc, Nr1f3, Rorg, Thor
Domain Architecture
Description	Nuclear receptor ROR-gamma (Nuclear receptor RZR-gamma) (Thymus orphan receptor) (TOR).

NR1H4_HUMAN
θ value	6.20254e-17 (rank : 92)	NC score	0.926737 (rank : 56)
Query Neighborhood Hits	157	Target Neighborhood Hits	112	Shared Neighborhood Hits	97
SwissProt Accessions	Q96RI1, Q8NFP5, Q8NFP6, Q92943	Gene names	NR1H4, BAR, FXR, HRR1, RIP14
Domain Architecture
Description	Bile acid receptor (Farnesoid X-activated receptor) (Farnesol receptor HRR-1) (Retinoid X receptor-interacting protein 14) (RXR-interacting protein 14).

RORG_HUMAN
θ value	4.02038e-16 (rank : 93)	NC score	0.887950 (rank : 94)
Query Neighborhood Hits	157	Target Neighborhood Hits	119	Shared Neighborhood Hits	96
SwissProt Accessions	P51449, Q8N5V7, Q8NCY8	Gene names	RORC, NR1F3, RORG, RZRG
Domain Architecture
Description	Nuclear receptor ROR-gamma (Nuclear receptor RZR-gamma).

NR1H4_MOUSE
θ value	2.60593e-15 (rank : 94)	NC score	0.924795 (rank : 61)
Query Neighborhood Hits	157	Target Neighborhood Hits	113	Shared Neighborhood Hits	97
SwissProt Accessions	Q60641, Q60642, Q60643	Gene names	Nr1h4, Bar, Fxr, Rip14
Domain Architecture
Description	Bile acid receptor (Farnesoid X-activated receptor) (Farnesol receptor HRR-1) (Retinoid X receptor-interacting protein 14) (RXR-interacting protein 14).

SHP_MOUSE
θ value	3.41135e-07 (rank : 95)	NC score	0.504510 (rank : 95)
Query Neighborhood Hits	157	Target Neighborhood Hits	53	Shared Neighborhood Hits	53
SwissProt Accessions	Q62227, Q53Z53	Gene names	Nr0b2, Shp
Domain Architecture
Description	Nuclear receptor 0B2 (Orphan nuclear receptor SHP) (Small heterodimer partner).

DAX1_MOUSE
θ value	0.00298849 (rank : 96)	NC score	0.503277 (rank : 97)
Query Neighborhood Hits	157	Target Neighborhood Hits	70	Shared Neighborhood Hits	60
SwissProt Accessions	Q61066, O09068, O09147	Gene names	Nr0b1, Ahch, Dax1
Domain Architecture
Description	Nuclear receptor 0B1 (Nuclear receptor DAX-1).

DIDO1_HUMAN
θ value	0.125558 (rank : 97)	NC score	0.012303 (rank : 102)
Query Neighborhood Hits	157	Target Neighborhood Hits	960	Shared Neighborhood Hits	31
SwissProt Accessions	Q9BTC0, O15043, Q3ZTL7, Q3ZTL8, Q4VXS1, Q4VXS2, Q96D72, Q9BQW0, Q9BW03, Q9H4G6, Q9H4G7, Q9NTU8, Q9NUM8, Q9UFB6	Gene names	DIDO1, C20orf158, DATF1, KIAA0333
Domain Architecture
Description	Death-inducer obliterator 1 (DIO-1) (Death-associated transcription factor 1) (DATF-1) (hDido1).

MMP19_HUMAN
θ value	0.125558 (rank : 98)	NC score	0.008078 (rank : 110)
Query Neighborhood Hits	157	Target Neighborhood Hits	51	Shared Neighborhood Hits	4
SwissProt Accessions	Q99542, O15278, O95606, Q99580	Gene names	MMP19, MMP18, RASI
Domain Architecture
Description	Matrix metalloproteinase-19 precursor (EC 3.4.24.-) (MMP-19) (Matrix metalloproteinase RASI) (MMP-18).

SHP_HUMAN
θ value	0.125558 (rank : 99)	NC score	0.503772 (rank : 96)
Query Neighborhood Hits	157	Target Neighborhood Hits	57	Shared Neighborhood Hits	56
SwissProt Accessions	Q15466, Q5QP36	Gene names	NR0B2, SHP
Domain Architecture
Description	Nuclear receptor 0B2 (Orphan nuclear receptor SHP) (Small heterodimer partner).

NFH_MOUSE
θ value	0.163984 (rank : 100)	NC score	0.003679 (rank : 129)
Query Neighborhood Hits	157	Target Neighborhood Hits	2247	Shared Neighborhood Hits	49
SwissProt Accessions	P19246, Q5SVF6, Q61959	Gene names	Nefh, Nfh
Domain Architecture
Description	Neurofilament triplet H protein (200 kDa neurofilament protein) (Neurofilament heavy polypeptide) (NF-H).

DGKK_HUMAN
θ value	0.279714 (rank : 101)	NC score	0.010843 (rank : 104)
Query Neighborhood Hits	157	Target Neighborhood Hits	378	Shared Neighborhood Hits	17
SwissProt Accessions	Q5KSL6	Gene names	DGKK
Domain Architecture	No domain graphic available
Description	Diacylglycerol kinase kappa (EC 2.7.1.107) (Diglyceride kinase kappa) (DGK-kappa) (DAG kinase kappa) (142 kDa diacylglycerol kinase).

OGFR_HUMAN
θ value	0.47712 (rank : 102)	NC score	0.018149 (rank : 99)
Query Neighborhood Hits	157	Target Neighborhood Hits	1582	Shared Neighborhood Hits	51
SwissProt Accessions	Q9NZT2, O96029, Q4VXW5, Q96CM2, Q9BQW1, Q9H4H0, Q9H7J5, Q9NZT3, Q9NZT4	Gene names	OGFR
Domain Architecture
Description	Opioid growth factor receptor (OGFr) (Zeta-type opioid receptor) (7-60 protein).

DAX1_HUMAN
θ value	0.62314 (rank : 103)	NC score	0.470727 (rank : 98)
Query Neighborhood Hits	157	Target Neighborhood Hits	65	Shared Neighborhood Hits	59
SwissProt Accessions	P51843, Q96F69	Gene names	NR0B1, AHC, DAX1
Domain Architecture
Description	Nuclear receptor 0B1 (Nuclear receptor DAX-1) (DSS-AHC critical region on the X chromosome protein 1).

BAT3_HUMAN
θ value	1.06291 (rank : 104)	NC score	0.011408 (rank : 103)
Query Neighborhood Hits	157	Target Neighborhood Hits	490	Shared Neighborhood Hits	20
SwissProt Accessions	P46379, O95874, Q5SQ35, Q5SQ36, Q5SQ37, Q5SRP8, Q96SA6, Q9BCN4	Gene names	BAT3, G3
Domain Architecture
Description	Large proline-rich protein BAT3 (HLA-B-associated transcript 3) (Protein G3).

E2F2_HUMAN
θ value	1.06291 (rank : 105)	NC score	0.007219 (rank : 112)
Query Neighborhood Hits	157	Target Neighborhood Hits	76	Shared Neighborhood Hits	4
SwissProt Accessions	Q14209	Gene names	E2F2
Domain Architecture
Description	Transcription factor E2F2 (E2F-2).

IF35_HUMAN
θ value	1.06291 (rank : 106)	NC score	0.017793 (rank : 100)
Query Neighborhood Hits	157	Target Neighborhood Hits	130	Shared Neighborhood Hits	11
SwissProt Accessions	O00303, Q8N978	Gene names	EIF3S5
Domain Architecture
Description	Eukaryotic translation initiation factor 3 subunit 5 (eIF-3 epsilon) (eIF3 p47 subunit) (eIF3f).

ANK2_HUMAN
θ value	1.38821 (rank : 107)	NC score	0.000724 (rank : 139)
Query Neighborhood Hits	157	Target Neighborhood Hits	1615	Shared Neighborhood Hits	37
SwissProt Accessions	Q01484, Q01485	Gene names	ANK2
Domain Architecture
Description	Ankyrin-2 (Brain ankyrin) (Ankyrin-B) (Ankyrin, nonerythroid).

IF35_MOUSE
θ value	1.38821 (rank : 108)	NC score	0.016037 (rank : 101)
Query Neighborhood Hits	157	Target Neighborhood Hits	210	Shared Neighborhood Hits	15
SwissProt Accessions	Q9DCH4	Gene names	Eif3s5
Domain Architecture
Description	Eukaryotic translation initiation factor 3 subunit 5 (eIF-3 epsilon) (eIF3 p47 subunit) (eIF3f).

PRG4_HUMAN
θ value	1.38821 (rank : 109)	NC score	0.006144 (rank : 117)
Query Neighborhood Hits	157	Target Neighborhood Hits	764	Shared Neighborhood Hits	22
SwissProt Accessions	Q92954, Q6DNC4, Q6DNC5, Q6ZMZ5, Q9BX49	Gene names	PRG4, MSF, SZP
Domain Architecture	No domain graphic available
Description	Proteoglycan-4 precursor (Lubricin) (Megakaryocyte-stimulating factor) (Superficial zone proteoglycan) [Contains: Proteoglycan-4 C-terminal part].

SON_MOUSE
θ value	1.38821 (rank : 110)	NC score	0.006903 (rank : 113)
Query Neighborhood Hits	157	Target Neighborhood Hits	957	Shared Neighborhood Hits	32
SwissProt Accessions	Q9QX47, Q9CQ12, Q9CQK6, Q9QXP5	Gene names	Son
Domain Architecture
Description	SON protein.

SRCA_HUMAN
θ value	1.38821 (rank : 111)	NC score	0.008858 (rank : 106)
Query Neighborhood Hits	157	Target Neighborhood Hits	380	Shared Neighborhood Hits	18
SwissProt Accessions	Q86TD4	Gene names	SRL
Domain Architecture	No domain graphic available
Description	Sarcalumenin precursor.

SRRM1_MOUSE
θ value	1.38821 (rank : 112)	NC score	0.008351 (rank : 108)
Query Neighborhood Hits	157	Target Neighborhood Hits	966	Shared Neighborhood Hits	34
SwissProt Accessions	Q52KI8, O70495, Q9CVG5	Gene names	Srrm1, Pop101
Domain Architecture	No domain graphic available
Description	Serine/arginine repetitive matrix protein 1 (Plenty-of-prolines 101).

EP400_MOUSE
θ value	1.81305 (rank : 113)	NC score	0.005654 (rank : 118)
Query Neighborhood Hits	157	Target Neighborhood Hits	592	Shared Neighborhood Hits	25
SwissProt Accessions	Q8CHI8, Q80TC8, Q8BXI5, Q8BYW3, Q8C0P6, Q8CHI7, Q8VDF4, Q9DA54	Gene names	Ep400, Kiaa1498
Domain Architecture	No domain graphic available
Description	E1A-binding protein p400 (EC 3.6.1.-) (p400 kDa SWI2/SNF2-related protein) (Domino homolog) (mDomino).

MMP19_MOUSE
θ value	1.81305 (rank : 114)	NC score	0.006253 (rank : 116)
Query Neighborhood Hits	157	Target Neighborhood Hits	56	Shared Neighborhood Hits	4
SwissProt Accessions	Q9JHI0, Q8C360	Gene names	Mmp19, Rasi
Domain Architecture
Description	Matrix metalloproteinase-19 precursor (EC 3.4.24.-) (MMP-19) (Matrix metalloproteinase RASI).

SPR1B_MOUSE
θ value	1.81305 (rank : 115)	NC score	0.008682 (rank : 107)
Query Neighborhood Hits	157	Target Neighborhood Hits	395	Shared Neighborhood Hits	25
SwissProt Accessions	Q62267	Gene names	Sprr1b
Domain Architecture
Description	Cornifin B (Small proline-rich protein 1B) (SPR1B) (SPR1 B).

CO5A2_HUMAN
θ value	2.36792 (rank : 116)	NC score	0.009559 (rank : 105)
Query Neighborhood Hits	157	Target Neighborhood Hits	760	Shared Neighborhood Hits	24
SwissProt Accessions	P05997	Gene names	COL5A2
Domain Architecture
Description	Collagen alpha-2(V) chain precursor.

RP1L1_HUMAN
θ value	2.36792 (rank : 117)	NC score	0.005080 (rank : 121)
Query Neighborhood Hits	157	Target Neighborhood Hits	1072	Shared Neighborhood Hits	26
SwissProt Accessions	Q8IWN7, Q86SQ1, Q8IWN8, Q8IWN9, Q8IWP0, Q8IWP1, Q8IWP2	Gene names	RP1L1
Domain Architecture
Description	Retinitis pigmentosa 1-like 1 protein.

SEM6B_HUMAN
θ value	2.36792 (rank : 118)	NC score	0.000927 (rank : 138)
Query Neighborhood Hits	157	Target Neighborhood Hits	187	Shared Neighborhood Hits	6
SwissProt Accessions	Q9H3T3, Q9NRK9	Gene names	SEMA6B, SEMAZ
Domain Architecture
Description	Semaphorin-6B precursor (Semaphorin Z) (Sema Z).

HUWE1_MOUSE
θ value	3.0926 (rank : 119)	NC score	0.003366 (rank : 132)
Query Neighborhood Hits	157	Target Neighborhood Hits	406	Shared Neighborhood Hits	12
SwissProt Accessions	Q7TMY8, Q4G2Z1, Q5BMM7, Q6NS61, Q8BNJ7, Q8CFH2, Q8VD14, Q921M5, Q9R0P2	Gene names	Huwe1, Kiaa0312, Ureb1
Domain Architecture	No domain graphic available
Description	HECT, UBA and WWE domain-containing protein 1 (EC 6.3.2.-) (E3 ubiquitin protein ligase URE-B1) (E3Histone).

SFPQ_HUMAN
θ value	3.0926 (rank : 120)	NC score	0.003794 (rank : 127)
Query Neighborhood Hits	157	Target Neighborhood Hits	986	Shared Neighborhood Hits	22
SwissProt Accessions	P23246, P30808	Gene names	SFPQ, PSF
Domain Architecture
Description	Splicing factor, proline- and glutamine-rich (Polypyrimidine tract- binding protein-associated-splicing factor) (PTB-associated-splicing factor) (PSF) (DNA-binding p52/p100 complex, 100 kDa subunit) (100 kDa DNA-pairing protein) (hPOMp100).

SYMPK_HUMAN
θ value	3.0926 (rank : 121)	NC score	0.008298 (rank : 109)
Query Neighborhood Hits	157	Target Neighborhood Hits	90	Shared Neighborhood Hits	5
SwissProt Accessions	Q92797, O00521, O00689, O00733, Q59GT5, Q8N2U5	Gene names	SYMPK, SPK
Domain Architecture	No domain graphic available
Description	Symplekin.

TIEG3_MOUSE
θ value	3.0926 (rank : 122)	NC score	-0.007017 (rank : 151)
Query Neighborhood Hits	157	Target Neighborhood Hits	774	Shared Neighborhood Hits	11
SwissProt Accessions	Q8K1S5, Q8BI37	Gene names	Tieg3, Tieg2b
Domain Architecture
Description	Transforming growth factor-beta-inducible early growth response protein 3 (TGFB-inducible early growth response protein 3) (TIEG-3) (TGFB-inducible early growth response protein 2b).

ZN659_HUMAN
θ value	3.0926 (rank : 123)	NC score	0.006791 (rank : 114)
Query Neighborhood Hits	157	Target Neighborhood Hits	43	Shared Neighborhood Hits	3
SwissProt Accessions	Q9H6B1	Gene names	ZNF659
Domain Architecture	No domain graphic available
Description	Zinc finger protein 659.

BSN_HUMAN
θ value	4.03905 (rank : 124)	NC score	0.004360 (rank : 126)
Query Neighborhood Hits	157	Target Neighborhood Hits	1537	Shared Neighborhood Hits	42
SwissProt Accessions	Q9UPA5, O43161, Q7LGH3	Gene names	BSN, KIAA0434, ZNF231
Domain Architecture	No domain graphic available
Description	Protein bassoon (Zinc finger protein 231).

CSKI1_HUMAN
θ value	4.03905 (rank : 125)	NC score	0.004525 (rank : 125)
Query Neighborhood Hits	157	Target Neighborhood Hits	997	Shared Neighborhood Hits	35
SwissProt Accessions	Q8WXD9, Q9P2P0	Gene names	CASKIN1, KIAA1306
Domain Architecture	No domain graphic available
Description	Caskin-1 (CASK-interacting protein 1).

MINT_MOUSE
θ value	4.03905 (rank : 126)	NC score	0.002961 (rank : 134)
Query Neighborhood Hits	157	Target Neighborhood Hits	1514	Shared Neighborhood Hits	38
SwissProt Accessions	Q62504, Q80TN9, Q99PS4, Q9QZW2	Gene names	Spen, Kiaa0929, Mint, Sharp
Domain Architecture
Description	Msx2-interacting protein (SPEN homolog) (SMART/HDAC1-associated repressor protein).

PO121_HUMAN
θ value	4.03905 (rank : 127)	NC score	0.007892 (rank : 111)
Query Neighborhood Hits	157	Target Neighborhood Hits	344	Shared Neighborhood Hits	13
SwissProt Accessions	Q9Y2N3, O75115, Q9Y4S7	Gene names	POM121, KIAA0618, NUP121
Domain Architecture	No domain graphic available
Description	Nuclear envelope pore membrane protein POM 121 (Pore membrane protein of 121 kDa) (P145).

ZBTB9_MOUSE
θ value	4.03905 (rank : 128)	NC score	-0.006204 (rank : 148)
Query Neighborhood Hits	157	Target Neighborhood Hits	780	Shared Neighborhood Hits	8
SwissProt Accessions	Q8CDC7, Q3U3B2, Q9CYQ0	Gene names	Zbtb9
Domain Architecture
Description	Zinc finger and BTB domain-containing protein 9.

PALB2_MOUSE
θ value	5.27518 (rank : 129)	NC score	0.006720 (rank : 115)
Query Neighborhood Hits	157	Target Neighborhood Hits	133	Shared Neighborhood Hits	9
SwissProt Accessions	Q3U0P1, Q6NZG9, Q7TMQ4, Q8CEA9	Gene names	Palb2
Domain Architecture	No domain graphic available
Description	Partner and localizer of BRCA2.

PRDM2_HUMAN
θ value	5.27518 (rank : 130)	NC score	-0.003928 (rank : 146)
Query Neighborhood Hits	157	Target Neighborhood Hits	1135	Shared Neighborhood Hits	22
SwissProt Accessions	Q13029, Q13149, Q14550, Q5VUL9	Gene names	PRDM2, RIZ
Domain Architecture
Description	PR domain zinc finger protein 2 (PR domain-containing protein 2) (Retinoblastoma protein-interacting zinc-finger protein) (Zinc finger protein RIZ) (MTE-binding protein) (MTB-ZF) (GATA-3-binding protein G3B).

SDK1_HUMAN
θ value	5.27518 (rank : 131)	NC score	-0.003766 (rank : 145)
Query Neighborhood Hits	157	Target Neighborhood Hits	511	Shared Neighborhood Hits	6
SwissProt Accessions	Q7Z5N4, Q8TEN9, Q8TEP5, Q96N44	Gene names	SDK1
Domain Architecture	No domain graphic available
Description	Protein sidekick-1 precursor.

SFPQ_MOUSE
θ value	5.27518 (rank : 132)	NC score	0.003695 (rank : 128)
Query Neighborhood Hits	157	Target Neighborhood Hits	958	Shared Neighborhood Hits	19
SwissProt Accessions	Q8VIJ6, Q9ERW2	Gene names	Sfpq
Domain Architecture	No domain graphic available
Description	Splicing factor, proline- and glutamine-rich (Polypyrimidine tract- binding protein-associated-splicing factor) (PTB-associated-splicing factor) (PSF) (DNA-binding p52/p100 complex, 100 kDa subunit).

TCOF_MOUSE
θ value	5.27518 (rank : 133)	NC score	0.005653 (rank : 119)
Query Neighborhood Hits	157	Target Neighborhood Hits	471	Shared Neighborhood Hits	14
SwissProt Accessions	O08784, O08857	Gene names	Tcof1
Domain Architecture
Description	Treacle protein (Treacher Collins syndrome protein homolog).

TSN10_MOUSE
θ value	5.27518 (rank : 134)	NC score	0.002714 (rank : 135)
Query Neighborhood Hits	157	Target Neighborhood Hits	50	Shared Neighborhood Hits	2
SwissProt Accessions	Q8VCF5	Gene names	Tspan10, Ocsp
Domain Architecture
Description	Tetraspanin-10 (Tspan-10) (Oculospanin).

ZN406_HUMAN
θ value	5.27518 (rank : 135)	NC score	-0.007651 (rank : 152)
Query Neighborhood Hits	157	Target Neighborhood Hits	794	Shared Neighborhood Hits	12
SwissProt Accessions	Q9P243, Q3MIM5, Q6PJ01, Q75PJ7, Q75PJ9, Q86X64	Gene names	ZNF406, KIAA1485
Domain Architecture	No domain graphic available
Description	Zinc finger protein 406 (Protein ZFAT).

ABL1_HUMAN
θ value	6.88961 (rank : 136)	NC score	-0.008996 (rank : 157)
Query Neighborhood Hits	157	Target Neighborhood Hits	1220	Shared Neighborhood Hits	18
SwissProt Accessions	P00519, Q13869, Q13870, Q16133, Q45F09	Gene names	ABL1, ABL, JTK7
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase ABL1 (EC 2.7.10.2) (p150) (c- ABL) (Abelson murine leukemia viral oncogene homolog 1).

ANK3_HUMAN
θ value	6.88961 (rank : 137)	NC score	-0.002159 (rank : 144)
Query Neighborhood Hits	157	Target Neighborhood Hits	853	Shared Neighborhood Hits	14
SwissProt Accessions	Q12955	Gene names	ANK3
Domain Architecture
Description	Ankyrin-3 (ANK-3) (Ankyrin-G).

APTX_MOUSE
θ value	6.88961 (rank : 138)	NC score	0.004936 (rank : 124)
Query Neighborhood Hits	157	Target Neighborhood Hits	29	Shared Neighborhood Hits	2
SwissProt Accessions	Q7TQC5, Q8BPA7, Q8C2B5, Q8K3D1, Q9CQ59	Gene names	Aptx
Domain Architecture
Description	Aprataxin homolog (Forkhead-associated domain histidine triad-like protein) (FHA-HIT).

CIC_HUMAN
θ value	6.88961 (rank : 139)	NC score	0.003493 (rank : 131)
Query Neighborhood Hits	157	Target Neighborhood Hits	992	Shared Neighborhood Hits	41
SwissProt Accessions	Q96RK0, Q7LGI1, Q9UEG5, Q9Y6T1	Gene names	CIC, KIAA0306
Domain Architecture	No domain graphic available
Description	Protein capicua homolog.

DDEF1_MOUSE
θ value	6.88961 (rank : 140)	NC score	-0.001992 (rank : 143)
Query Neighborhood Hits	157	Target Neighborhood Hits	592	Shared Neighborhood Hits	9
SwissProt Accessions	Q9QWY8, O08612, Q80TG8, Q80UV6, Q99LV8, Q9Z2B6	Gene names	Ddef1, Asap1, Kiaa1249, Shag1
Domain Architecture
Description	130 kDa phosphatidylinositol 4,5-biphosphate-dependent ARF1 GTPase- activating protein (PIP2-dependent ARF1 GAP) (ADP-ribosylation factor- directed GTPase-activating protein 1) (ARF GTPase-activating protein 1) (Development and differentiation-enhancing factor 1) (Differentiation-enhancing factor 1) (DEF-1).

EKI2_HUMAN
θ value	6.88961 (rank : 141)	NC score	0.004949 (rank : 123)
Query Neighborhood Hits	157	Target Neighborhood Hits	10	Shared Neighborhood Hits	2
SwissProt Accessions	Q9NVF9	Gene names	ETNK2, EKI2
Domain Architecture
Description	Ethanolamine kinase 2 (EC 2.7.1.82) (EKI 2) (Ethanolamine kinase-like protein).

FOG1_HUMAN
θ value	6.88961 (rank : 142)	NC score	-0.004996 (rank : 147)
Query Neighborhood Hits	157	Target Neighborhood Hits	981	Shared Neighborhood Hits	28
SwissProt Accessions	Q8IX07	Gene names	ZFPM1, FOG1
Domain Architecture	No domain graphic available
Description	Zinc finger protein ZFPM1 (Zinc finger protein multitype 1) (Friend of GATA protein 1) (Friend of GATA-1) (FOG-1).

HUWE1_HUMAN
θ value	6.88961 (rank : 143)	NC score	0.002707 (rank : 136)
Query Neighborhood Hits	157	Target Neighborhood Hits	443	Shared Neighborhood Hits	12
SwissProt Accessions	Q7Z6Z7, O15029, Q4G2Z2, Q5H961, Q6P4D0, Q8NG67, Q9BUI0, Q9HCJ4, Q9NSL6, Q9P0A9	Gene names	HUWE1, KIAA0312, KIAA1578, UREB1
Domain Architecture	No domain graphic available
Description	HECT, UBA and WWE domain-containing protein 1 (EC 6.3.2.-) (E3 ubiquitin protein ligase URE-B1) (Mcl-1 ubiquitin ligase E3) (Mule) (ARF-binding protein 1) (ARF-BP1).

IP3KB_HUMAN
θ value	6.88961 (rank : 144)	NC score	0.005642 (rank : 120)
Query Neighborhood Hits	157	Target Neighborhood Hits	124	Shared Neighborhood Hits	9
SwissProt Accessions	P27987, Q5VWL9, Q5VWM0, Q96BZ2, Q96JS1, Q9UH47	Gene names	ITPKB
Domain Architecture
Description	Inositol-trisphosphate 3-kinase B (EC 2.7.1.127) (Inositol 1,4,5- trisphosphate 3-kinase B) (IP3K B) (IP3 3-kinase B) (IP3K-B).

MARE1_MOUSE
θ value	6.88961 (rank : 145)	NC score	0.003258 (rank : 133)
Query Neighborhood Hits	157	Target Neighborhood Hits	22	Shared Neighborhood Hits	3
SwissProt Accessions	Q61166, Q7TN34	Gene names	Mapre1
Domain Architecture	No domain graphic available
Description	Microtubule-associated protein RP/EB family member 1 (APC-binding protein EB1) (End-binding protein 1) (EB1).

SPEG_MOUSE
θ value	6.88961 (rank : 146)	NC score	-0.008713 (rank : 155)
Query Neighborhood Hits	157	Target Neighborhood Hits	1959	Shared Neighborhood Hits	37
SwissProt Accessions	Q62407, Q3TPH8, Q6P5V1, Q80TF7, Q80ZN0, Q8BZF4, Q9EQJ5	Gene names	Speg, Apeg1, Kiaa1297
Domain Architecture
Description	Striated muscle-specific serine/threonine protein kinase (EC 2.7.11.1) (Aortic preferentially expressed protein 1) (APEG-1).

ZBTB4_HUMAN
θ value	6.88961 (rank : 147)	NC score	-0.006964 (rank : 150)
Query Neighborhood Hits	157	Target Neighborhood Hits	926	Shared Neighborhood Hits	14
SwissProt Accessions	Q9P1Z0, Q7Z697, Q86XJ4, Q8N4V8	Gene names	ZBTB4, KIAA1538
Domain Architecture
Description	Zinc finger and BTB domain-containing protein 4 (KAISO-like zinc finger protein 1) (KAISO-L1).

ZYX_MOUSE
θ value	6.88961 (rank : 148)	NC score	-0.000065 (rank : 141)
Query Neighborhood Hits	157	Target Neighborhood Hits	347	Shared Neighborhood Hits	10
SwissProt Accessions	Q62523, P70461	Gene names	Zyx
Domain Architecture
Description	Zyxin.

DDX51_HUMAN
θ value	8.99809 (rank : 149)	NC score	-0.000301 (rank : 142)
Query Neighborhood Hits	157	Target Neighborhood Hits	332	Shared Neighborhood Hits	15
SwissProt Accessions	Q8N8A6, Q5CZ71, Q8IXK5, Q96ED1	Gene names	DDX51
Domain Architecture	No domain graphic available
Description	ATP-dependent RNA helicase DDX51 (EC 3.6.1.-) (DEAD box protein 51).

EGR4_HUMAN
θ value	8.99809 (rank : 150)	NC score	-0.006871 (rank : 149)
Query Neighborhood Hits	157	Target Neighborhood Hits	939	Shared Neighborhood Hits	19
SwissProt Accessions	Q05215	Gene names	EGR4
Domain Architecture
Description	Early growth response protein 4 (EGR-4) (AT133).

GSCR1_HUMAN
θ value	8.99809 (rank : 151)	NC score	0.005032 (rank : 122)
Query Neighborhood Hits	157	Target Neighborhood Hits	674	Shared Neighborhood Hits	24
SwissProt Accessions	Q9NZM4	Gene names	GLTSCR1
Domain Architecture	No domain graphic available
Description	Glioma tumor suppressor candidate region gene 1 protein.

HCN2_HUMAN
θ value	8.99809 (rank : 152)	NC score	0.000550 (rank : 140)
Query Neighborhood Hits	157	Target Neighborhood Hits	369	Shared Neighborhood Hits	20
SwissProt Accessions	Q9UL51, O60742, O60743, O75267, Q9UBS2	Gene names	HCN2, BCNG2
Domain Architecture
Description	Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 (Brain cyclic nucleotide-gated channel 2) (BCNG-2).

K1543_MOUSE
θ value	8.99809 (rank : 153)	NC score	0.003605 (rank : 130)
Query Neighborhood Hits	157	Target Neighborhood Hits	497	Shared Neighborhood Hits	21
SwissProt Accessions	Q80VC9, Q5DTW9, Q8BUZ0	Gene names	Kiaa1543
Domain Architecture	No domain graphic available
Description	Protein KIAA1543.

MILK2_HUMAN
θ value	8.99809 (rank : 154)	NC score	0.001409 (rank : 137)
Query Neighborhood Hits	157	Target Neighborhood Hits	457	Shared Neighborhood Hits	15
SwissProt Accessions	Q8IY33, Q7RTP4, Q7Z655, Q8TEQ4, Q9H5F9	Gene names
Domain Architecture
Description	MICAL-like protein 2.

MK07_HUMAN
θ value	8.99809 (rank : 155)	NC score	-0.008150 (rank : 154)
Query Neighborhood Hits	157	Target Neighborhood Hits	1087	Shared Neighborhood Hits	18
SwissProt Accessions	Q13164, Q16634	Gene names	MAPK7, ERK4, ERK5, PRKM7
Domain Architecture
Description	Mitogen-activated protein kinase 7 (EC 2.7.11.24) (Extracellular signal-regulated kinase 5) (ERK-5) (ERK4) (BMK1 kinase).

MK07_MOUSE
θ value	8.99809 (rank : 156)	NC score	-0.008108 (rank : 153)
Query Neighborhood Hits	157	Target Neighborhood Hits	1054	Shared Neighborhood Hits	17
SwissProt Accessions	Q9WVS8	Gene names	Mapk7, Erk5
Domain Architecture
Description	Mitogen-activated protein kinase 7 (EC 2.7.11.24) (Extracellular signal-regulated kinase 5) (ERK-5) (BMK1 kinase).

TESK2_HUMAN
θ value	8.99809 (rank : 157)	NC score	-0.008947 (rank : 156)
Query Neighborhood Hits	157	Target Neighborhood Hits	851	Shared Neighborhood Hits	7
SwissProt Accessions	Q96S53, Q8N520, Q9Y3Q6	Gene names	TESK2
Domain Architecture
Description	Dual specificity testis-specific protein kinase 2 (EC 2.7.12.1) (Testicular protein kinase 2).

Hits sorted by NC score

ERR1_HUMAN
NC score	0.999962 (rank : 1)	θ value	0 (rank : 1)
Query Neighborhood Hits	157	Target Neighborhood Hits	157	Shared Neighborhood Hits	157
SwissProt Accessions	P11474, Q14514	Gene names	ESRRA, ERR1, ESRL1, NR3B1
Domain Architecture
Description	Steroid hormone receptor ERR1 (Estrogen-related receptor, alpha) (ERR- alpha) (Estrogen receptor-like 1).

ERR2_HUMAN
NC score	0.994828 (rank : 2)	θ value	4.30305e-127 (rank : 4)
Query Neighborhood Hits	157	Target Neighborhood Hits	108	Shared Neighborhood Hits	98
SwissProt Accessions	O95718, Q9HCB4	Gene names	ESRRB, ERRB2, NR3B2
Domain Architecture
Description	Steroid hormone receptor ERR2 (Estrogen-related receptor, beta) (ERR- beta) (Estrogen receptor-like 2) (ERR beta-2).

ERR3_HUMAN
NC score	0.994135 (rank : 3)	θ value	6.19918e-134 (rank : 2)
Query Neighborhood Hits	157	Target Neighborhood Hits	106	Shared Neighborhood Hits	98
SwissProt Accessions	P62508, O75454, O96021, Q68DA0, Q6P274, Q6PK28, Q6TS38, Q9R1F3, Q9UNJ4	Gene names	ESRRG, ERR3, ERRG2, KIAA0832, NR3B3
Domain Architecture	No domain graphic available
Description	Estrogen-related receptor gamma (Estrogen receptor-related protein 3) (ERR gamma-2).

ERR3_MOUSE
NC score	0.994135 (rank : 4)	θ value	6.19918e-134 (rank : 3)
Query Neighborhood Hits	157	Target Neighborhood Hits	106	Shared Neighborhood Hits	98
SwissProt Accessions	P62509, O75454, O96021, Q8CHC9, Q9R1F3	Gene names	Esrrg, Err3, Kiaa0832, Nr3b3
Domain Architecture	No domain graphic available
Description	Estrogen-related receptor gamma (Estrogen receptor-related protein 3).

ERR2_MOUSE
NC score	0.994109 (rank : 5)	θ value	4.75757e-126 (rank : 5)
Query Neighborhood Hits	157	Target Neighborhood Hits	109	Shared Neighborhood Hits	98
SwissProt Accessions	Q61539, O09067, O09146	Gene names	Esrrb, Err-2, Err2, Nr3b2
Domain Architecture
Description	Steroid hormone receptor ERR2 (Estrogen-related receptor, beta) (ERR- beta) (Estrogen receptor-like 2).

ESR2_HUMAN
NC score	0.976223 (rank : 6)	θ value	3.25095e-58 (rank : 6)
Query Neighborhood Hits	157	Target Neighborhood Hits	110	Shared Neighborhood Hits	98
SwissProt Accessions	Q92731, O60608, O60685, O60702, O60703, O75583, O75584, Q86Z31, Q9UEV6, Q9UHD3, Q9UQK9	Gene names	ESR2, ESTRB, NR3A2
Domain Architecture
Description	Estrogen receptor beta (ER-beta).

ESR1_MOUSE
NC score	0.976219 (rank : 7)	θ value	1.51013e-55 (rank : 8)
Query Neighborhood Hits	157	Target Neighborhood Hits	104	Shared Neighborhood Hits	95
SwissProt Accessions	P19785, Q9JJT5, Q9QY51, Q9QY52	Gene names	Esr1, Esr, Estr, Estra, Nr3a1
Domain Architecture
Description	Estrogen receptor (ER) (Estradiol receptor) (ER-alpha).

ESR2_MOUSE
NC score	0.975803 (rank : 8)	θ value	3.974e-56 (rank : 7)
Query Neighborhood Hits	157	Target Neighborhood Hits	110	Shared Neighborhood Hits	97
SwissProt Accessions	O08537, O35635, O70519	Gene names	Esr2, Estrb, Nr3a2
Domain Architecture
Description	Estrogen receptor beta (ER-beta).

ESR1_HUMAN
NC score	0.975264 (rank : 9)	θ value	3.71957e-54 (rank : 9)
Query Neighborhood Hits	157	Target Neighborhood Hits	105	Shared Neighborhood Hits	95
SwissProt Accessions	P03372, Q13511, Q14276, Q9NU51, Q9UDZ7, Q9UIS7	Gene names	ESR1, ESR, NR3A1
Domain Architecture
Description	Estrogen receptor (ER) (Estradiol receptor) (ER-alpha).

RXRG_MOUSE
NC score	0.959615 (rank : 10)	θ value	8.32485e-38 (rank : 25)
Query Neighborhood Hits	157	Target Neighborhood Hits	113	Shared Neighborhood Hits	98
SwissProt Accessions	P28705	Gene names	Rxrg, Nr2b3
Domain Architecture
Description	Retinoic acid receptor RXR-gamma (Retinoid X receptor gamma).

RXRG_HUMAN
NC score	0.959095 (rank : 11)	θ value	1.6774e-38 (rank : 23)
Query Neighborhood Hits	157	Target Neighborhood Hits	114	Shared Neighborhood Hits	99
SwissProt Accessions	P48443	Gene names	RXRG, NR2B3
Domain Architecture
Description	Retinoic acid receptor RXR-gamma (Retinoid X receptor gamma).

RXRA_MOUSE
NC score	0.959022 (rank : 12)	θ value	1.73182e-43 (rank : 15)
Query Neighborhood Hits	157	Target Neighborhood Hits	129	Shared Neighborhood Hits	99
SwissProt Accessions	P28700	Gene names	Rxra, Nr2b1
Domain Architecture
Description	Retinoic acid receptor RXR-alpha (Retinoid X receptor alpha).

NR2E1_MOUSE
NC score	0.957050 (rank : 13)	θ value	2.34606e-32 (rank : 49)
Query Neighborhood Hits	157	Target Neighborhood Hits	106	Shared Neighborhood Hits	98
SwissProt Accessions	Q64104	Gene names	Nr2e1, Tll, Tlx
Domain Architecture
Description	Orphan nuclear receptor NR2E1 (Nuclear receptor TLX) (Tailless homolog) (Tll) (mTll).

RXRA_HUMAN
NC score	0.956389 (rank : 14)	θ value	1.19932e-44 (rank : 10)
Query Neighborhood Hits	157	Target Neighborhood Hits	223	Shared Neighborhood Hits	104
SwissProt Accessions	P19793, Q2V504	Gene names	RXRA, NR2B1
Domain Architecture
Description	Retinoic acid receptor RXR-alpha (Retinoid X receptor alpha).

HNF4G_MOUSE
NC score	0.956270 (rank : 15)	θ value	6.59618e-35 (rank : 40)
Query Neighborhood Hits	157	Target Neighborhood Hits	101	Shared Neighborhood Hits	98
SwissProt Accessions	Q9WUU6	Gene names	Hnf4g, Nr2a2
Domain Architecture
Description	Hepatocyte nuclear factor 4-gamma (HNF-4-gamma).

HNF4G_HUMAN
NC score	0.956091 (rank : 16)	θ value	2.26708e-35 (rank : 39)
Query Neighborhood Hits	157	Target Neighborhood Hits	100	Shared Neighborhood Hits	98
SwissProt Accessions	Q14541, Q9UH81, Q9UIS6	Gene names	HNF4G, NR2A2
Domain Architecture
Description	Hepatocyte nuclear factor 4-gamma (HNF-4-gamma).

NR2E1_HUMAN
NC score	0.955991 (rank : 17)	θ value	6.38894e-30 (rank : 55)
Query Neighborhood Hits	157	Target Neighborhood Hits	103	Shared Neighborhood Hits	98
SwissProt Accessions	Q9Y466	Gene names	NR2E1, TLX
Domain Architecture
Description	Orphan nuclear receptor NR2E1 (Nuclear receptor TLX) (Tailless homolog) (Tll) (hTll).

EAR2_HUMAN
NC score	0.955842 (rank : 18)	θ value	8.06329e-33 (rank : 47)
Query Neighborhood Hits	157	Target Neighborhood Hits	106	Shared Neighborhood Hits	98
SwissProt Accessions	P10588, Q9BUE8	Gene names	NR2F6, EAR2, ERBAL2
Domain Architecture
Description	Orphan nuclear receptor EAR-2 (V-erbA-related protein EAR-2).

EAR2_MOUSE
NC score	0.955762 (rank : 19)	θ value	1.28434e-38 (rank : 22)
Query Neighborhood Hits	157	Target Neighborhood Hits	104	Shared Neighborhood Hits	98
SwissProt Accessions	P43136, Q61504	Gene names	Nr2f6, Ear-2, Ear2, Erbal2
Domain Architecture
Description	Orphan nuclear receptor EAR-2 (V-erbA-related protein EAR-2).

NR2E3_MOUSE
NC score	0.955362 (rank : 20)	θ value	5.584e-34 (rank : 44)
Query Neighborhood Hits	157	Target Neighborhood Hits	113	Shared Neighborhood Hits	98
SwissProt Accessions	Q9QXZ7	Gene names	Nr2e3, Pnr, Rnr
Domain Architecture
Description	Photoreceptor-specific nuclear receptor (Retina-specific nuclear receptor).

RXRB_MOUSE
NC score	0.955297 (rank : 21)	θ value	2.58786e-39 (rank : 20)
Query Neighborhood Hits	157	Target Neighborhood Hits	230	Shared Neighborhood Hits	101
SwissProt Accessions	P28704, P33243	Gene names	Rxrb, Nr2b2
Domain Architecture
Description	Retinoic acid receptor RXR-beta (Retinoid X receptor beta) (MHC class I regulatory element-binding protein H-2RIIBP).

HNF4A_MOUSE
NC score	0.955177 (rank : 22)	θ value	8.61488e-35 (rank : 42)
Query Neighborhood Hits	157	Target Neighborhood Hits	103	Shared Neighborhood Hits	98
SwissProt Accessions	P49698	Gene names	Hnf4a, Hnf-4, Hnf4, Nr2a1, Tcf14
Domain Architecture
Description	Hepatocyte nuclear factor 4-alpha (HNF-4-alpha) (Transcription factor HNF-4) (Transcription factor 14).

HNF4A_HUMAN
NC score	0.955126 (rank : 23)	θ value	5.39604e-37 (rank : 30)
Query Neighborhood Hits	157	Target Neighborhood Hits	105	Shared Neighborhood Hits	98
SwissProt Accessions	P41235, O00659, O00723, Q14540, Q92653, Q92654, Q92655, Q99864, Q9NQH0	Gene names	HNF4A, HNF4, NR2A1, TCF14
Domain Architecture
Description	Hepatocyte nuclear factor 4-alpha (HNF-4-alpha) (Transcription factor HNF-4) (Transcription factor 14).

COT2_HUMAN
NC score	0.953815 (rank : 24)	θ value	1.73182e-43 (rank : 13)
Query Neighborhood Hits	157	Target Neighborhood Hits	135	Shared Neighborhood Hits	102
SwissProt Accessions	P24468, Q03754	Gene names	NR2F2, ARP1, TFCOUP2
Domain Architecture
Description	COUP transcription factor 2 (COUP-TF2) (COUP-TF II) (Apolipoprotein AI regulatory protein 1) (ARP-1).

COT2_MOUSE
NC score	0.953815 (rank : 25)	θ value	1.73182e-43 (rank : 14)
Query Neighborhood Hits	157	Target Neighborhood Hits	135	Shared Neighborhood Hits	102
SwissProt Accessions	P43135	Gene names	Nr2f2, Aporp1, Arp-1, Arp1, Tfcoup2
Domain Architecture
Description	COUP transcription factor 2 (COUP-TF2) (COUP-TF II) (Apolipoprotein AI regulatory protein 1) (ARP-1).

RXRB_HUMAN
NC score	0.952794 (rank : 26)	θ value	1.98146e-39 (rank : 19)
Query Neighborhood Hits	157	Target Neighborhood Hits	280	Shared Neighborhood Hits	107
SwissProt Accessions	P28702, P28703	Gene names	RXRB, NR2B2
Domain Architecture
Description	Retinoic acid receptor RXR-beta (Retinoid X receptor beta).

COT1_MOUSE
NC score	0.952375 (rank : 27)	θ value	1.56636e-44 (rank : 12)
Query Neighborhood Hits	157	Target Neighborhood Hits	160	Shared Neighborhood Hits	100
SwissProt Accessions	Q60632, Q61438	Gene names	Nr2f1, Erbal3, Tfcoup1
Domain Architecture
Description	COUP transcription factor 1 (COUP-TF1) (COUP-TF I).

COT1_HUMAN
NC score	0.952093 (rank : 28)	θ value	1.56636e-44 (rank : 11)
Query Neighborhood Hits	157	Target Neighborhood Hits	159	Shared Neighborhood Hits	101
SwissProt Accessions	P10589	Gene names	NR2F1, EAR3, ERBAL3, TFCOUP1
Domain Architecture
Description	COUP transcription factor 1 (COUP-TF1) (COUP-TF I) (V-ERBA-related protein EAR-3).

NR2E3_HUMAN
NC score	0.951840 (rank : 29)	θ value	6.82597e-32 (rank : 52)
Query Neighborhood Hits	157	Target Neighborhood Hits	102	Shared Neighborhood Hits	98
SwissProt Accessions	Q9Y5X4, Q9UHM4	Gene names	NR2E3, PNR, RNR
Domain Architecture
Description	Photoreceptor-specific nuclear receptor (Retina-specific nuclear receptor).

NR4A2_HUMAN
NC score	0.951427 (rank : 30)	θ value	1.08726e-37 (rank : 26)
Query Neighborhood Hits	157	Target Neighborhood Hits	120	Shared Neighborhood Hits	94
SwissProt Accessions	P43354, Q16311	Gene names	NR4A2, NOT, NURR1, TINUR
Domain Architecture
Description	Orphan nuclear receptor NR4A2 (Orphan nuclear receptor NURR1) (Immediate-early response protein NOT) (Transcriptionally-inducible nuclear receptor).

NR4A2_MOUSE
NC score	0.951376 (rank : 31)	θ value	1.08726e-37 (rank : 27)
Query Neighborhood Hits	157	Target Neighborhood Hits	121	Shared Neighborhood Hits	94
SwissProt Accessions	Q06219, O08690	Gene names	Nr4a2, Nurr1
Domain Architecture
Description	Orphan nuclear receptor NR4A2 (Orphan nuclear receptor NURR1) (NUR- related factor 1).

NR4A1_HUMAN
NC score	0.951338 (rank : 32)	θ value	6.59618e-35 (rank : 41)
Query Neighborhood Hits	157	Target Neighborhood Hits	133	Shared Neighborhood Hits	98
SwissProt Accessions	P22736	Gene names	NR4A1, GFRP1, HMR, NAK1
Domain Architecture
Description	Orphan nuclear receptor NR4A1 (Orphan nuclear receptor HMR) (Early response protein NAK1) (TR3 orphan receptor) (ST-59).

NR4A3_MOUSE
NC score	0.951110 (rank : 33)	θ value	1.08726e-37 (rank : 28)
Query Neighborhood Hits	157	Target Neighborhood Hits	127	Shared Neighborhood Hits	95
SwissProt Accessions	Q9QZB6, Q9QZB5	Gene names	Nr4a3, Tec
Domain Architecture
Description	Orphan nuclear receptor NR4A3 (Orphan nuclear receptor TEC) (Translocated in extraskeletal chondrosarcoma).

NR4A3_HUMAN
NC score	0.951056 (rank : 34)	θ value	9.20422e-37 (rank : 33)
Query Neighborhood Hits	157	Target Neighborhood Hits	131	Shared Neighborhood Hits	96
SwissProt Accessions	Q92570, Q12935, Q14979, Q16420, Q4VXA9, Q9UEK2, Q9UEK3	Gene names	NR4A3, CHN, CSMF, MINOR, NOR1, TEC
Domain Architecture
Description	Orphan nuclear receptor NR4A3 (Nuclear hormone receptor NOR-1) (Neuron-derived orphan receptor 1) (Mitogen-induced nuclear orphan receptor).

NR4A1_MOUSE
NC score	0.950194 (rank : 35)	θ value	1.6247e-33 (rank : 46)
Query Neighborhood Hits	157	Target Neighborhood Hits	128	Shared Neighborhood Hits	94
SwissProt Accessions	P12813	Gene names	Nr4a1, Gfrp, Hmr, N10, Nur77
Domain Architecture
Description	Orphan nuclear receptor NR4A1 (Orphan nuclear receptor HMR) (Nuclear hormone receptor NUR/77) (N10 nuclear protein).

RARG1_HUMAN
NC score	0.944697 (rank : 36)	θ value	3.4976e-36 (rank : 36)
Query Neighborhood Hits	157	Target Neighborhood Hits	107	Shared Neighborhood Hits	95
SwissProt Accessions	P13631	Gene names	RARG, NR1B3
Domain Architecture
Description	Retinoic acid receptor gamma-1 (RAR-gamma-1).

RARG2_HUMAN
NC score	0.944602 (rank : 37)	θ value	3.4976e-36 (rank : 37)
Query Neighborhood Hits	157	Target Neighborhood Hits	109	Shared Neighborhood Hits	95
SwissProt Accessions	P22932, Q15281	Gene names	RARG, NR1B3
Domain Architecture	No domain graphic available
Description	Retinoic acid receptor gamma-2 (RAR-gamma-2).

RARG2_MOUSE
NC score	0.944223 (rank : 38)	θ value	5.39604e-37 (rank : 32)
Query Neighborhood Hits	157	Target Neighborhood Hits	114	Shared Neighborhood Hits	96
SwissProt Accessions	P20787	Gene names	Rarg, Nr1b3
Domain Architecture
Description	Retinoic acid receptor gamma-B (RAR-gamma-B).

RARG1_MOUSE
NC score	0.944129 (rank : 39)	θ value	5.39604e-37 (rank : 31)
Query Neighborhood Hits	157	Target Neighborhood Hits	113	Shared Neighborhood Hits	96
SwissProt Accessions	P18911, Q91VK5	Gene names	Rarg, Nr1b3
Domain Architecture
Description	Retinoic acid receptor gamma-A (RAR-gamma-A).

RARA_MOUSE
NC score	0.942914 (rank : 40)	θ value	1.08726e-37 (rank : 29)
Query Neighborhood Hits	157	Target Neighborhood Hits	113	Shared Neighborhood Hits	96
SwissProt Accessions	P11416, P22603	Gene names	Rara, Nr1b1
Domain Architecture
Description	Retinoic acid receptor alpha (RAR-alpha).

RARA_HUMAN
NC score	0.942827 (rank : 41)	θ value	8.32485e-38 (rank : 24)
Query Neighborhood Hits	157	Target Neighborhood Hits	118	Shared Neighborhood Hits	96
SwissProt Accessions	P10276, P78456, Q13440, Q13441, Q9NQS0	Gene names	RARA, NR1B1
Domain Architecture
Description	Retinoic acid receptor alpha (RAR-alpha).

RARB_HUMAN
NC score	0.942591 (rank : 42)	θ value	9.20422e-37 (rank : 34)
Query Neighborhood Hits	157	Target Neighborhood Hits	118	Shared Neighborhood Hits	94
SwissProt Accessions	P10826, P12891, Q00989, Q15298, Q9UN48	Gene names	RARB, HAP, NR1B2
Domain Architecture
Description	Retinoic acid receptor beta (RAR-beta) (RAR-epsilon) (HBV-activated protein).

RARB_MOUSE
NC score	0.942200 (rank : 43)	θ value	9.20422e-37 (rank : 35)
Query Neighborhood Hits	157	Target Neighborhood Hits	109	Shared Neighborhood Hits	94
SwissProt Accessions	P22605, P11417, P22604	Gene names	Rarb, Nr1b2
Domain Architecture
Description	Retinoic acid receptor beta (RAR-beta).

NR1I3_MOUSE
NC score	0.936553 (rank : 44)	θ value	5.97985e-28 (rank : 56)
Query Neighborhood Hits	157	Target Neighborhood Hits	103	Shared Neighborhood Hits	98
SwissProt Accessions	O35627, O35628	Gene names	Nr1i3, Car
Domain Architecture
Description	Orphan nuclear receptor NR1I3 (Constitutive androstane receptor) (CAR) (Orphan nuclear receptor MB67).

GCR_HUMAN
NC score	0.936292 (rank : 45)	θ value	8.04462e-41 (rank : 16)
Query Neighborhood Hits	157	Target Neighborhood Hits	113	Shared Neighborhood Hits	94
SwissProt Accessions	P04150, P04151, Q53EP5, Q6N0A4	Gene names	NR3C1, GRL
Domain Architecture
Description	Glucocorticoid receptor (GR).

NR1I3_HUMAN
NC score	0.936203 (rank : 46)	θ value	1.2077e-20 (rank : 68)
Query Neighborhood Hits	157	Target Neighborhood Hits	107	Shared Neighborhood Hits	98
SwissProt Accessions	Q14994	Gene names	NR1I3, CAR
Domain Architecture
Description	Orphan nuclear receptor NR1I3 (Constitutive androstane receptor) (CAR) (Constitutive activator of retinoid response) (Constitutive active response) (Orphan nuclear receptor MB67).

NR1H3_HUMAN
NC score	0.934162 (rank : 47)	θ value	5.77852e-31 (rank : 53)
Query Neighborhood Hits	157	Target Neighborhood Hits	104	Shared Neighborhood Hits	96
SwissProt Accessions	Q13133, Q96H87	Gene names	NR1H3, LXRA
Domain Architecture
Description	Oxysterols receptor LXR-alpha (Liver X receptor alpha) (Nuclear orphan receptor LXR-alpha).

NR1H3_MOUSE
NC score	0.933540 (rank : 48)	θ value	3.74554e-30 (rank : 54)
Query Neighborhood Hits	157	Target Neighborhood Hits	102	Shared Neighborhood Hits	94
SwissProt Accessions	Q9Z0Y9, Q9QUH7	Gene names	Nr1h3, Lxra
Domain Architecture
Description	Oxysterols receptor LXR-alpha (Liver X receptor alpha) (Nuclear orphan receptor LXR-alpha).

GCR_MOUSE
NC score	0.932065 (rank : 49)	θ value	7.52953e-39 (rank : 21)
Query Neighborhood Hits	157	Target Neighborhood Hits	117	Shared Neighborhood Hits	94
SwissProt Accessions	P06537, Q61628, Q61629	Gene names	Nr3c1, Grl, Grl1
Domain Architecture
Description	Glucocorticoid receptor (GR).

PRGR_HUMAN
NC score	0.929637 (rank : 50)	θ value	8.89434e-40 (rank : 18)
Query Neighborhood Hits	157	Target Neighborhood Hits	163	Shared Neighborhood Hits	99
SwissProt Accessions	P06401, Q9UPF7	Gene names	PGR, NR3C3
Domain Architecture
Description	Progesterone receptor (PR).

STF1_HUMAN
NC score	0.929223 (rank : 51)	θ value	5.59698e-26 (rank : 62)
Query Neighborhood Hits	157	Target Neighborhood Hits	132	Shared Neighborhood Hits	99
SwissProt Accessions	Q13285, O15196	Gene names	NR5A1, AD4BP, FTZF1, SF1
Domain Architecture
Description	Steroidogenic factor 1 (STF-1) (SF-1) (Adrenal 4-binding protein) (Steroid hormone receptor Ad4BP) (Fushi tarazu factor homolog 1).

STF1_MOUSE
NC score	0.929055 (rank : 52)	θ value	1.24688e-25 (rank : 63)
Query Neighborhood Hits	157	Target Neighborhood Hits	137	Shared Neighborhood Hits	98
SwissProt Accessions	P33242	Gene names	Nr5a1, Ftzf1
Domain Architecture
Description	Steroidogenic factor 1 (STF-1) (SF-1) (Adrenal 4-binding protein) (Steroid hormone receptor Ad4BP) (Fushi tarazu factor homolog 1) (Embryonal LTR-binding protein) (ELP) (Embryonal long terminal repeat- binding protein) (Steroid hydroxylase positive regulator).

ANDR_MOUSE
NC score	0.928777 (rank : 53)	θ value	1.46948e-34 (rank : 43)
Query Neighborhood Hits	157	Target Neighborhood Hits	133	Shared Neighborhood Hits	94
SwissProt Accessions	P19091	Gene names	Ar, Nr3c4
Domain Architecture
Description	Androgen receptor (Dihydrotestosterone receptor).

ANDR_HUMAN
NC score	0.928179 (rank : 54)	θ value	1.0531e-32 (rank : 48)
Query Neighborhood Hits	157	Target Neighborhood Hits	126	Shared Neighborhood Hits	94
SwissProt Accessions	P10275	Gene names	AR, DHTR, NR3C4
Domain Architecture
Description	Androgen receptor (Dihydrotestosterone receptor).

MCR_HUMAN
NC score	0.927724 (rank : 55)	θ value	4.568e-36 (rank : 38)
Query Neighborhood Hits	157	Target Neighborhood Hits	149	Shared Neighborhood Hits	96
SwissProt Accessions	P08235, Q96KQ8, Q96KQ9	Gene names	NR3C2, MCR, MLR
Domain Architecture
Description	Mineralocorticoid receptor (MR).

NR1H4_HUMAN
NC score	0.926737 (rank : 56)	θ value	6.20254e-17 (rank : 92)
Query Neighborhood Hits	157	Target Neighborhood Hits	112	Shared Neighborhood Hits	97
SwissProt Accessions	Q96RI1, Q8NFP5, Q8NFP6, Q92943	Gene names	NR1H4, BAR, FXR, HRR1, RIP14
Domain Architecture
Description	Bile acid receptor (Farnesoid X-activated receptor) (Farnesol receptor HRR-1) (Retinoid X receptor-interacting protein 14) (RXR-interacting protein 14).

NR6A1_HUMAN
NC score	0.926224 (rank : 57)	θ value	1.2077e-20 (rank : 69)
Query Neighborhood Hits	157	Target Neighborhood Hits	108	Shared Neighborhood Hits	98
SwissProt Accessions	Q15406, O00551, O00603, Q8NHQ0, Q92898, Q99802	Gene names	NR6A1, GCNF
Domain Architecture
Description	Orphan nuclear receptor NR6A1 (Germ cell nuclear factor) (GCNF) (Retinoid receptor-related testis-specific receptor) (RTR).

NR6A1_MOUSE
NC score	0.926121 (rank : 58)	θ value	2.69047e-20 (rank : 73)
Query Neighborhood Hits	157	Target Neighborhood Hits	110	Shared Neighborhood Hits	98
SwissProt Accessions	Q64249	Gene names	Nr6a1, Gcnf
Domain Architecture
Description	Orphan nuclear receptor NR6A1 (Germ cell nuclear factor) (GCNF) (Retinoid receptor-related testis-specific receptor) (RTR).

THA_HUMAN
NC score	0.924964 (rank : 59)	θ value	5.22648e-32 (rank : 51)
Query Neighborhood Hits	157	Target Neighborhood Hits	113	Shared Neighborhood Hits	98
SwissProt Accessions	P10827, P21205, Q8N6A1, Q96H73	Gene names	THRA, ERBA1, NR1A1, THRA1
Domain Architecture
Description	Thyroid hormone receptor alpha (C-erbA-alpha) (c-erbA-1) (EAR-7) (EAR7).

THA_MOUSE
NC score	0.924881 (rank : 60)	θ value	4.00176e-32 (rank : 50)
Query Neighborhood Hits	157	Target Neighborhood Hits	113	Shared Neighborhood Hits	98
SwissProt Accessions	P63058, P10685, P15827, P16416, P37241, Q63107, Q63195, Q63196, Q99146	Gene names	Thra, C-erba-alpha, Nr1a1
Domain Architecture	No domain graphic available
Description	Thyroid hormone receptor alpha (C-erbA-alpha) (c-erbA-1).

NR1H4_MOUSE
NC score	0.924795 (rank : 61)	θ value	2.60593e-15 (rank : 94)
Query Neighborhood Hits	157	Target Neighborhood Hits	113	Shared Neighborhood Hits	97
SwissProt Accessions	Q60641, Q60642, Q60643	Gene names	Nr1h4, Bar, Fxr, Rip14
Domain Architecture
Description	Bile acid receptor (Farnesoid X-activated receptor) (Farnesol receptor HRR-1) (Retinoid X receptor-interacting protein 14) (RXR-interacting protein 14).

MCR_MOUSE
NC score	0.924711 (rank : 62)	θ value	7.29293e-34 (rank : 45)
Query Neighborhood Hits	157	Target Neighborhood Hits	162	Shared Neighborhood Hits	95
SwissProt Accessions	Q8VII8, Q8VII9	Gene names	Nr3c2, Mlr
Domain Architecture	No domain graphic available
Description	Mineralocorticoid receptor (MR).

NR1H2_MOUSE
NC score	0.924216 (rank : 63)	θ value	5.07402e-19 (rank : 76)
Query Neighborhood Hits	157	Target Neighborhood Hits	109	Shared Neighborhood Hits	96
SwissProt Accessions	Q60644	Gene names	Nr1h2, Lxrb, Rip15, Unr, Unr2
Domain Architecture
Description	Oxysterols receptor LXR-beta (Liver X receptor beta) (Nuclear orphan receptor LXR-beta) (Ubiquitously-expressed nuclear receptor) (Retinoid X receptor-interacting protein No.15).

NR5A2_MOUSE
NC score	0.923943 (rank : 64)	θ value	6.18819e-25 (rank : 65)
Query Neighborhood Hits	157	Target Neighborhood Hits	107	Shared Neighborhood Hits	98
SwissProt Accessions	P45448	Gene names	Nr5a2, Lrh1
Domain Architecture
Description	Orphan nuclear receptor NR5A2 (Liver receptor homolog 1) (LRH-1).

PRGR_MOUSE
NC score	0.923131 (rank : 65)	θ value	6.81017e-40 (rank : 17)
Query Neighborhood Hits	157	Target Neighborhood Hits	286	Shared Neighborhood Hits	108
SwissProt Accessions	Q00175	Gene names	Pgr, Nr3c3, Pr
Domain Architecture
Description	Progesterone receptor (PR).

NR5A2_HUMAN
NC score	0.921872 (rank : 66)	θ value	2.77775e-25 (rank : 64)
Query Neighborhood Hits	157	Target Neighborhood Hits	112	Shared Neighborhood Hits	98
SwissProt Accessions	O00482, O95642	Gene names	NR5A2, B1F, CPF, FTF
Domain Architecture
Description	Orphan nuclear receptor NR5A2 (Alpha-1-fetoprotein transcription factor) (Hepatocytic transcription factor) (B1-binding factor) (hB1F) (CYP7A promoter-binding factor) (Liver receptor homolog 1) (LRH-1).

NR1H2_HUMAN
NC score	0.917791 (rank : 67)	θ value	2.7842e-17 (rank : 89)
Query Neighborhood Hits	157	Target Neighborhood Hits	114	Shared Neighborhood Hits	96
SwissProt Accessions	P55055, Q12970	Gene names	NR1H2, LXRB, NER, UNR
Domain Architecture
Description	Oxysterols receptor LXR-beta (Liver X receptor beta) (Nuclear orphan receptor LXR-beta) (Ubiquitously-expressed nuclear receptor) (Nuclear receptor NER).

THB2_HUMAN
NC score	0.917352 (rank : 68)	θ value	2.51237e-26 (rank : 61)
Query Neighborhood Hits	157	Target Neighborhood Hits	104	Shared Neighborhood Hits	98
SwissProt Accessions	P37243	Gene names	THRB, ERBA2, NR1A2, THR1
Domain Architecture	No domain graphic available
Description	Thyroid hormone receptor beta-2.

THB1_HUMAN
NC score	0.916527 (rank : 69)	θ value	1.92365e-26 (rank : 60)
Query Neighborhood Hits	157	Target Neighborhood Hits	106	Shared Neighborhood Hits	98
SwissProt Accessions	P10828, Q13986	Gene names	THRB, ERBA2, NR1A2, THR1
Domain Architecture
Description	Thyroid hormone receptor beta-1.

THB1_MOUSE
NC score	0.915646 (rank : 70)	θ value	1.47289e-26 (rank : 58)
Query Neighborhood Hits	157	Target Neighborhood Hits	105	Shared Neighborhood Hits	98
SwissProt Accessions	P37242	Gene names	Thrb, C-erba-beta, Nr1a2
Domain Architecture
Description	Thyroid hormone receptor beta-1.

THB2_MOUSE
NC score	0.915469 (rank : 71)	θ value	1.47289e-26 (rank : 59)
Query Neighborhood Hits	157	Target Neighborhood Hits	106	Shared Neighborhood Hits	98
SwissProt Accessions	P37244	Gene names	Thrb, C-erba-beta, Nr1a2
Domain Architecture
Description	Thyroid hormone receptor beta-2.

VDR_MOUSE
NC score	0.915415 (rank : 72)	θ value	1.73987e-27 (rank : 57)
Query Neighborhood Hits	157	Target Neighborhood Hits	103	Shared Neighborhood Hits	96
SwissProt Accessions	P48281	Gene names	Vdr, Nr1i1
Domain Architecture
Description	Vitamin D3 receptor (VDR) (1,25-dihydroxyvitamin D3 receptor).

TR2_HUMAN
NC score	0.914669 (rank : 73)	θ value	1.13037e-18 (rank : 77)
Query Neighborhood Hits	157	Target Neighborhood Hits	110	Shared Neighborhood Hits	97
SwissProt Accessions	P13056	Gene names	NR2C1, TR2
Domain Architecture
Description	Orphan nuclear receptor TR2 (Testicular receptor 2).

NR1D1_HUMAN
NC score	0.912808 (rank : 74)	θ value	2.69047e-20 (rank : 72)
Query Neighborhood Hits	157	Target Neighborhood Hits	140	Shared Neighborhood Hits	96
SwissProt Accessions	P20393, Q15304	Gene names	NR1D1, EAR1, HREV, THRAL
Domain Architecture
Description	Orphan nuclear receptor NR1D1 (V-erbA-related protein EAR-1) (Rev- erbA-alpha).

PXR_MOUSE
NC score	0.912377 (rank : 75)	θ value	1.5242e-23 (rank : 66)
Query Neighborhood Hits	157	Target Neighborhood Hits	107	Shared Neighborhood Hits	97
SwissProt Accessions	O54915	Gene names	Nr1i2, Pxr
Domain Architecture
Description	Orphan nuclear receptor PXR (Pregnane X receptor).

VDR_HUMAN
NC score	0.910693 (rank : 76)	θ value	1.92812e-18 (rank : 79)
Query Neighborhood Hits	157	Target Neighborhood Hits	112	Shared Neighborhood Hits	96
SwissProt Accessions	P11473	Gene names	VDR, NR1I1
Domain Architecture
Description	Vitamin D3 receptor (VDR) (1,25-dihydroxyvitamin D3 receptor).

PXR_HUMAN
NC score	0.907601 (rank : 77)	θ value	9.24701e-21 (rank : 67)
Query Neighborhood Hits	157	Target Neighborhood Hits	107	Shared Neighborhood Hits	97
SwissProt Accessions	O75469, Q96AC7, Q9UJ22, Q9UJ23, Q9UJ24, Q9UJ25, Q9UJ26, Q9UJ27	Gene names	NR1I2, PXR
Domain Architecture
Description	Orphan nuclear receptor PXR (Pregnane X receptor) (Orphan nuclear receptor PAR1) (Steroid and xenobiotic receptor) (SXR).

NR1D2_HUMAN
NC score	0.906753 (rank : 78)	θ value	2.06002e-20 (rank : 70)
Query Neighborhood Hits	157	Target Neighborhood Hits	115	Shared Neighborhood Hits	94
SwissProt Accessions	Q14995, O00402, Q86XD4	Gene names	NR1D2
Domain Architecture
Description	Orphan nuclear receptor NR1D2 (Rev-erb-beta) (EAR-1R) (Orphan nuclear hormone receptor BD73).

TR2_MOUSE
NC score	0.905784 (rank : 79)	θ value	1.13037e-18 (rank : 78)
Query Neighborhood Hits	157	Target Neighborhood Hits	100	Shared Neighborhood Hits	98
SwissProt Accessions	Q505F1, P97763, Q3UIJ7, Q4U1Z4, Q60927, Q62152, Q8VIJ3	Gene names	Nr2c1, Tr2, Tr2-11
Domain Architecture	No domain graphic available
Description	Orphan nuclear receptor TR2 (Testicular receptor 2) (mTR2).

TR4_HUMAN
NC score	0.904598 (rank : 80)	θ value	2.97466e-19 (rank : 75)
Query Neighborhood Hits	157	Target Neighborhood Hits	117	Shared Neighborhood Hits	99
SwissProt Accessions	P49116, P55092	Gene names	NR2C2, TAK1, TR4
Domain Architecture
Description	Orphan nuclear receptor TR4 (Orphan nuclear receptor TAK1).

TR4_MOUSE
NC score	0.904415 (rank : 81)	θ value	1.33526e-19 (rank : 74)
Query Neighborhood Hits	157	Target Neighborhood Hits	115	Shared Neighborhood Hits	99
SwissProt Accessions	P49117, P55093	Gene names	Nr2c2, Mtr2r1, Tak1, Tr4
Domain Architecture
Description	Orphan nuclear receptor TR4 (Orphan nuclear receptor TAK1).

NR1D2_MOUSE
NC score	0.903720 (rank : 82)	θ value	2.06002e-20 (rank : 71)
Query Neighborhood Hits	157	Target Neighborhood Hits	109	Shared Neighborhood Hits	94
SwissProt Accessions	Q60674, Q60646	Gene names	Nr1d2
Domain Architecture
Description	Orphan nuclear receptor NR1D2 (Rev-erb-beta) (Orphan nuclear receptor RVR).

PPARA_MOUSE
NC score	0.903166 (rank : 83)	θ value	3.28887e-18 (rank : 80)
Query Neighborhood Hits	157	Target Neighborhood Hits	99	Shared Neighborhood Hits	95
SwissProt Accessions	P23204	Gene names	Ppara, Nr1c1, Ppar
Domain Architecture
Description	Peroxisome proliferator-activated receptor alpha (PPAR-alpha).

PPARA_HUMAN
NC score	0.902971 (rank : 84)	θ value	1.63225e-17 (rank : 87)
Query Neighborhood Hits	157	Target Neighborhood Hits	100	Shared Neighborhood Hits	94
SwissProt Accessions	Q07869, Q16241, Q92486, Q92689, Q9Y3N1	Gene names	PPARA, NR1C1, PPAR
Domain Architecture
Description	Peroxisome proliferator-activated receptor alpha (PPAR-alpha).

PPARG_HUMAN
NC score	0.900364 (rank : 85)	θ value	5.60996e-18 (rank : 81)
Query Neighborhood Hits	157	Target Neighborhood Hits	97	Shared Neighborhood Hits	94
SwissProt Accessions	P37231, O00684, O00710, O14515, Q15178, Q15179, Q15180, Q15832, Q86U60, Q96J12	Gene names	PPARG, NR1C3
Domain Architecture
Description	Peroxisome proliferator-activated receptor gamma (PPAR-gamma).

PPARG_MOUSE
NC score	0.899933 (rank : 86)	θ value	2.7842e-17 (rank : 90)
Query Neighborhood Hits	157	Target Neighborhood Hits	97	Shared Neighborhood Hits	94
SwissProt Accessions	P37238	Gene names	Pparg, Nr1c3
Domain Architecture
Description	Peroxisome proliferator-activated receptor gamma (PPAR-gamma).

PPARD_HUMAN
NC score	0.899875 (rank : 87)	θ value	9.56915e-18 (rank : 86)
Query Neighborhood Hits	157	Target Neighborhood Hits	102	Shared Neighborhood Hits	94
SwissProt Accessions	Q03181, Q7Z5K0, Q9BUD4	Gene names	PPARD, NR1C2, PPARB
Domain Architecture
Description	Peroxisome proliferator-activated receptor delta (PPAR-delta) (PPAR- beta) (Nuclear hormone receptor 1) (NUC1) (NUCI).

PPARD_MOUSE
NC score	0.897459 (rank : 88)	θ value	2.13179e-17 (rank : 88)
Query Neighborhood Hits	157	Target Neighborhood Hits	103	Shared Neighborhood Hits	95
SwissProt Accessions	P35396, P37239	Gene names	Ppard, Nr1c2, Pparb
Domain Architecture
Description	Peroxisome proliferator-activated receptor delta (PPAR-delta) (PPAR- beta) (Nuclear hormone receptor 1) (NUC1).

RORG_MOUSE
NC score	0.893241 (rank : 89)	θ value	4.74913e-17 (rank : 91)
Query Neighborhood Hits	157	Target Neighborhood Hits	107	Shared Neighborhood Hits	94
SwissProt Accessions	P51450, Q61027, Q91YT5, Q9QXD9, Q9R177	Gene names	Rorc, Nr1f3, Rorg, Thor
Domain Architecture
Description	Nuclear receptor ROR-gamma (Nuclear receptor RZR-gamma) (Thymus orphan receptor) (TOR).

RORA_HUMAN
NC score	0.893062 (rank : 90)	θ value	5.60996e-18 (rank : 82)
Query Neighborhood Hits	157	Target Neighborhood Hits	105	Shared Neighborhood Hits	94
SwissProt Accessions	P35398, P35397, P35399, P45445, Q96H83	Gene names	RORA, NR1F1, RZRA
Domain Architecture
Description	Nuclear receptor ROR-alpha (Nuclear receptor RZR-alpha).

RORB_MOUSE
NC score	0.892691 (rank : 91)	θ value	7.32683e-18 (rank : 85)
Query Neighborhood Hits	157	Target Neighborhood Hits	99	Shared Neighborhood Hits	94
SwissProt Accessions	Q8R1B8	Gene names	Rorb, Nr1f2
Domain Architecture
Description	Nuclear receptor ROR-beta (Nuclear receptor RZR-beta).

RORB_HUMAN
NC score	0.892429 (rank : 92)	θ value	7.32683e-18 (rank : 84)
Query Neighborhood Hits	157	Target Neighborhood Hits	99	Shared Neighborhood Hits	94
SwissProt Accessions	Q92753, Q8WX73	Gene names	RORB, NR1F2, RZRB
Domain Architecture
Description	Nuclear receptor ROR-beta (Nuclear receptor RZR-beta).

RORA_MOUSE
NC score	0.891736 (rank : 93)	θ value	5.60996e-18 (rank : 83)
Query Neighborhood Hits	157	Target Neighborhood Hits	105	Shared Neighborhood Hits	94
SwissProt Accessions	P51448, P70283, P97741, P97773, Q923G1	Gene names	Rora, Nr1f1, Rzra
Domain Architecture
Description	Nuclear receptor ROR-alpha (Nuclear receptor RZR-alpha).

RORG_HUMAN
NC score	0.887950 (rank : 94)	θ value	4.02038e-16 (rank : 93)
Query Neighborhood Hits	157	Target Neighborhood Hits	119	Shared Neighborhood Hits	96
SwissProt Accessions	P51449, Q8N5V7, Q8NCY8	Gene names	RORC, NR1F3, RORG, RZRG
Domain Architecture
Description	Nuclear receptor ROR-gamma (Nuclear receptor RZR-gamma).

SHP_MOUSE
NC score	0.504510 (rank : 95)	θ value	3.41135e-07 (rank : 95)
Query Neighborhood Hits	157	Target Neighborhood Hits	53	Shared Neighborhood Hits	53
SwissProt Accessions	Q62227, Q53Z53	Gene names	Nr0b2, Shp
Domain Architecture
Description	Nuclear receptor 0B2 (Orphan nuclear receptor SHP) (Small heterodimer partner).

SHP_HUMAN
NC score	0.503772 (rank : 96)	θ value	0.125558 (rank : 99)
Query Neighborhood Hits	157	Target Neighborhood Hits	57	Shared Neighborhood Hits	56
SwissProt Accessions	Q15466, Q5QP36	Gene names	NR0B2, SHP
Domain Architecture
Description	Nuclear receptor 0B2 (Orphan nuclear receptor SHP) (Small heterodimer partner).

DAX1_MOUSE
NC score	0.503277 (rank : 97)	θ value	0.00298849 (rank : 96)
Query Neighborhood Hits	157	Target Neighborhood Hits	70	Shared Neighborhood Hits	60
SwissProt Accessions	Q61066, O09068, O09147	Gene names	Nr0b1, Ahch, Dax1
Domain Architecture
Description	Nuclear receptor 0B1 (Nuclear receptor DAX-1).

DAX1_HUMAN
NC score	0.470727 (rank : 98)	θ value	0.62314 (rank : 103)
Query Neighborhood Hits	157	Target Neighborhood Hits	65	Shared Neighborhood Hits	59
SwissProt Accessions	P51843, Q96F69	Gene names	NR0B1, AHC, DAX1
Domain Architecture
Description	Nuclear receptor 0B1 (Nuclear receptor DAX-1) (DSS-AHC critical region on the X chromosome protein 1).

OGFR_HUMAN
NC score	0.018149 (rank : 99)	θ value	0.47712 (rank : 102)
Query Neighborhood Hits	157	Target Neighborhood Hits	1582	Shared Neighborhood Hits	51
SwissProt Accessions	Q9NZT2, O96029, Q4VXW5, Q96CM2, Q9BQW1, Q9H4H0, Q9H7J5, Q9NZT3, Q9NZT4	Gene names	OGFR
Domain Architecture
Description	Opioid growth factor receptor (OGFr) (Zeta-type opioid receptor) (7-60 protein).

IF35_HUMAN
NC score	0.017793 (rank : 100)	θ value	1.06291 (rank : 106)
Query Neighborhood Hits	157	Target Neighborhood Hits	130	Shared Neighborhood Hits	11
SwissProt Accessions	O00303, Q8N978	Gene names	EIF3S5
Domain Architecture
Description	Eukaryotic translation initiation factor 3 subunit 5 (eIF-3 epsilon) (eIF3 p47 subunit) (eIF3f).

IF35_MOUSE
NC score	0.016037 (rank : 101)	θ value	1.38821 (rank : 108)
Query Neighborhood Hits	157	Target Neighborhood Hits	210	Shared Neighborhood Hits	15
SwissProt Accessions	Q9DCH4	Gene names	Eif3s5
Domain Architecture
Description	Eukaryotic translation initiation factor 3 subunit 5 (eIF-3 epsilon) (eIF3 p47 subunit) (eIF3f).

DIDO1_HUMAN
NC score	0.012303 (rank : 102)	θ value	0.125558 (rank : 97)
Query Neighborhood Hits	157	Target Neighborhood Hits	960	Shared Neighborhood Hits	31
SwissProt Accessions	Q9BTC0, O15043, Q3ZTL7, Q3ZTL8, Q4VXS1, Q4VXS2, Q96D72, Q9BQW0, Q9BW03, Q9H4G6, Q9H4G7, Q9NTU8, Q9NUM8, Q9UFB6	Gene names	DIDO1, C20orf158, DATF1, KIAA0333
Domain Architecture
Description	Death-inducer obliterator 1 (DIO-1) (Death-associated transcription factor 1) (DATF-1) (hDido1).

BAT3_HUMAN
NC score	0.011408 (rank : 103)	θ value	1.06291 (rank : 104)
Query Neighborhood Hits	157	Target Neighborhood Hits	490	Shared Neighborhood Hits	20
SwissProt Accessions	P46379, O95874, Q5SQ35, Q5SQ36, Q5SQ37, Q5SRP8, Q96SA6, Q9BCN4	Gene names	BAT3, G3
Domain Architecture
Description	Large proline-rich protein BAT3 (HLA-B-associated transcript 3) (Protein G3).

DGKK_HUMAN
NC score	0.010843 (rank : 104)	θ value	0.279714 (rank : 101)
Query Neighborhood Hits	157	Target Neighborhood Hits	378	Shared Neighborhood Hits	17
SwissProt Accessions	Q5KSL6	Gene names	DGKK
Domain Architecture	No domain graphic available
Description	Diacylglycerol kinase kappa (EC 2.7.1.107) (Diglyceride kinase kappa) (DGK-kappa) (DAG kinase kappa) (142 kDa diacylglycerol kinase).

CO5A2_HUMAN
NC score	0.009559 (rank : 105)	θ value	2.36792 (rank : 116)
Query Neighborhood Hits	157	Target Neighborhood Hits	760	Shared Neighborhood Hits	24
SwissProt Accessions	P05997	Gene names	COL5A2
Domain Architecture
Description	Collagen alpha-2(V) chain precursor.

SRCA_HUMAN
NC score	0.008858 (rank : 106)	θ value	1.38821 (rank : 111)
Query Neighborhood Hits	157	Target Neighborhood Hits	380	Shared Neighborhood Hits	18
SwissProt Accessions	Q86TD4	Gene names	SRL
Domain Architecture	No domain graphic available
Description	Sarcalumenin precursor.

SPR1B_MOUSE
NC score	0.008682 (rank : 107)	θ value	1.81305 (rank : 115)
Query Neighborhood Hits	157	Target Neighborhood Hits	395	Shared Neighborhood Hits	25
SwissProt Accessions	Q62267	Gene names	Sprr1b
Domain Architecture
Description	Cornifin B (Small proline-rich protein 1B) (SPR1B) (SPR1 B).

SRRM1_MOUSE
NC score	0.008351 (rank : 108)	θ value	1.38821 (rank : 112)
Query Neighborhood Hits	157	Target Neighborhood Hits	966	Shared Neighborhood Hits	34
SwissProt Accessions	Q52KI8, O70495, Q9CVG5	Gene names	Srrm1, Pop101
Domain Architecture	No domain graphic available
Description	Serine/arginine repetitive matrix protein 1 (Plenty-of-prolines 101).

SYMPK_HUMAN
NC score	0.008298 (rank : 109)	θ value	3.0926 (rank : 121)
Query Neighborhood Hits	157	Target Neighborhood Hits	90	Shared Neighborhood Hits	5
SwissProt Accessions	Q92797, O00521, O00689, O00733, Q59GT5, Q8N2U5	Gene names	SYMPK, SPK
Domain Architecture	No domain graphic available
Description	Symplekin.

MMP19_HUMAN
NC score	0.008078 (rank : 110)	θ value	0.125558 (rank : 98)
Query Neighborhood Hits	157	Target Neighborhood Hits	51	Shared Neighborhood Hits	4
SwissProt Accessions	Q99542, O15278, O95606, Q99580	Gene names	MMP19, MMP18, RASI
Domain Architecture
Description	Matrix metalloproteinase-19 precursor (EC 3.4.24.-) (MMP-19) (Matrix metalloproteinase RASI) (MMP-18).

PO121_HUMAN
NC score	0.007892 (rank : 111)	θ value	4.03905 (rank : 127)
Query Neighborhood Hits	157	Target Neighborhood Hits	344	Shared Neighborhood Hits	13
SwissProt Accessions	Q9Y2N3, O75115, Q9Y4S7	Gene names	POM121, KIAA0618, NUP121
Domain Architecture	No domain graphic available
Description	Nuclear envelope pore membrane protein POM 121 (Pore membrane protein of 121 kDa) (P145).

E2F2_HUMAN
NC score	0.007219 (rank : 112)	θ value	1.06291 (rank : 105)
Query Neighborhood Hits	157	Target Neighborhood Hits	76	Shared Neighborhood Hits	4
SwissProt Accessions	Q14209	Gene names	E2F2
Domain Architecture
Description	Transcription factor E2F2 (E2F-2).

SON_MOUSE
NC score	0.006903 (rank : 113)	θ value	1.38821 (rank : 110)
Query Neighborhood Hits	157	Target Neighborhood Hits	957	Shared Neighborhood Hits	32
SwissProt Accessions	Q9QX47, Q9CQ12, Q9CQK6, Q9QXP5	Gene names	Son
Domain Architecture
Description	SON protein.

ZN659_HUMAN
NC score	0.006791 (rank : 114)	θ value	3.0926 (rank : 123)
Query Neighborhood Hits	157	Target Neighborhood Hits	43	Shared Neighborhood Hits	3
SwissProt Accessions	Q9H6B1	Gene names	ZNF659
Domain Architecture	No domain graphic available
Description	Zinc finger protein 659.

PALB2_MOUSE
NC score	0.006720 (rank : 115)	θ value	5.27518 (rank : 129)
Query Neighborhood Hits	157	Target Neighborhood Hits	133	Shared Neighborhood Hits	9
SwissProt Accessions	Q3U0P1, Q6NZG9, Q7TMQ4, Q8CEA9	Gene names	Palb2
Domain Architecture	No domain graphic available
Description	Partner and localizer of BRCA2.

MMP19_MOUSE
NC score	0.006253 (rank : 116)	θ value	1.81305 (rank : 114)
Query Neighborhood Hits	157	Target Neighborhood Hits	56	Shared Neighborhood Hits	4
SwissProt Accessions	Q9JHI0, Q8C360	Gene names	Mmp19, Rasi
Domain Architecture
Description	Matrix metalloproteinase-19 precursor (EC 3.4.24.-) (MMP-19) (Matrix metalloproteinase RASI).

PRG4_HUMAN
NC score	0.006144 (rank : 117)	θ value	1.38821 (rank : 109)
Query Neighborhood Hits	157	Target Neighborhood Hits	764	Shared Neighborhood Hits	22
SwissProt Accessions	Q92954, Q6DNC4, Q6DNC5, Q6ZMZ5, Q9BX49	Gene names	PRG4, MSF, SZP
Domain Architecture	No domain graphic available
Description	Proteoglycan-4 precursor (Lubricin) (Megakaryocyte-stimulating factor) (Superficial zone proteoglycan) [Contains: Proteoglycan-4 C-terminal part].

EP400_MOUSE
NC score	0.005654 (rank : 118)	θ value	1.81305 (rank : 113)
Query Neighborhood Hits	157	Target Neighborhood Hits	592	Shared Neighborhood Hits	25
SwissProt Accessions	Q8CHI8, Q80TC8, Q8BXI5, Q8BYW3, Q8C0P6, Q8CHI7, Q8VDF4, Q9DA54	Gene names	Ep400, Kiaa1498
Domain Architecture	No domain graphic available
Description	E1A-binding protein p400 (EC 3.6.1.-) (p400 kDa SWI2/SNF2-related protein) (Domino homolog) (mDomino).

TCOF_MOUSE
NC score	0.005653 (rank : 119)	θ value	5.27518 (rank : 133)
Query Neighborhood Hits	157	Target Neighborhood Hits	471	Shared Neighborhood Hits	14
SwissProt Accessions	O08784, O08857	Gene names	Tcof1
Domain Architecture
Description	Treacle protein (Treacher Collins syndrome protein homolog).

IP3KB_HUMAN
NC score	0.005642 (rank : 120)	θ value	6.88961 (rank : 144)
Query Neighborhood Hits	157	Target Neighborhood Hits	124	Shared Neighborhood Hits	9
SwissProt Accessions	P27987, Q5VWL9, Q5VWM0, Q96BZ2, Q96JS1, Q9UH47	Gene names	ITPKB
Domain Architecture
Description	Inositol-trisphosphate 3-kinase B (EC 2.7.1.127) (Inositol 1,4,5- trisphosphate 3-kinase B) (IP3K B) (IP3 3-kinase B) (IP3K-B).

RP1L1_HUMAN
NC score	0.005080 (rank : 121)	θ value	2.36792 (rank : 117)
Query Neighborhood Hits	157	Target Neighborhood Hits	1072	Shared Neighborhood Hits	26
SwissProt Accessions	Q8IWN7, Q86SQ1, Q8IWN8, Q8IWN9, Q8IWP0, Q8IWP1, Q8IWP2	Gene names	RP1L1
Domain Architecture
Description	Retinitis pigmentosa 1-like 1 protein.

GSCR1_HUMAN
NC score	0.005032 (rank : 122)	θ value	8.99809 (rank : 151)
Query Neighborhood Hits	157	Target Neighborhood Hits	674	Shared Neighborhood Hits	24
SwissProt Accessions	Q9NZM4	Gene names	GLTSCR1
Domain Architecture	No domain graphic available
Description	Glioma tumor suppressor candidate region gene 1 protein.

EKI2_HUMAN
NC score	0.004949 (rank : 123)	θ value	6.88961 (rank : 141)
Query Neighborhood Hits	157	Target Neighborhood Hits	10	Shared Neighborhood Hits	2
SwissProt Accessions	Q9NVF9	Gene names	ETNK2, EKI2
Domain Architecture
Description	Ethanolamine kinase 2 (EC 2.7.1.82) (EKI 2) (Ethanolamine kinase-like protein).

APTX_MOUSE
NC score	0.004936 (rank : 124)	θ value	6.88961 (rank : 138)
Query Neighborhood Hits	157	Target Neighborhood Hits	29	Shared Neighborhood Hits	2
SwissProt Accessions	Q7TQC5, Q8BPA7, Q8C2B5, Q8K3D1, Q9CQ59	Gene names	Aptx
Domain Architecture
Description	Aprataxin homolog (Forkhead-associated domain histidine triad-like protein) (FHA-HIT).

CSKI1_HUMAN
NC score	0.004525 (rank : 125)	θ value	4.03905 (rank : 125)
Query Neighborhood Hits	157	Target Neighborhood Hits	997	Shared Neighborhood Hits	35
SwissProt Accessions	Q8WXD9, Q9P2P0	Gene names	CASKIN1, KIAA1306
Domain Architecture	No domain graphic available
Description	Caskin-1 (CASK-interacting protein 1).

BSN_HUMAN
NC score	0.004360 (rank : 126)	θ value	4.03905 (rank : 124)
Query Neighborhood Hits	157	Target Neighborhood Hits	1537	Shared Neighborhood Hits	42
SwissProt Accessions	Q9UPA5, O43161, Q7LGH3	Gene names	BSN, KIAA0434, ZNF231
Domain Architecture	No domain graphic available
Description	Protein bassoon (Zinc finger protein 231).

SFPQ_HUMAN
NC score	0.003794 (rank : 127)	θ value	3.0926 (rank : 120)
Query Neighborhood Hits	157	Target Neighborhood Hits	986	Shared Neighborhood Hits	22
SwissProt Accessions	P23246, P30808	Gene names	SFPQ, PSF
Domain Architecture
Description	Splicing factor, proline- and glutamine-rich (Polypyrimidine tract- binding protein-associated-splicing factor) (PTB-associated-splicing factor) (PSF) (DNA-binding p52/p100 complex, 100 kDa subunit) (100 kDa DNA-pairing protein) (hPOMp100).

SFPQ_MOUSE
NC score	0.003695 (rank : 128)	θ value	5.27518 (rank : 132)
Query Neighborhood Hits	157	Target Neighborhood Hits	958	Shared Neighborhood Hits	19
SwissProt Accessions	Q8VIJ6, Q9ERW2	Gene names	Sfpq
Domain Architecture	No domain graphic available
Description	Splicing factor, proline- and glutamine-rich (Polypyrimidine tract- binding protein-associated-splicing factor) (PTB-associated-splicing factor) (PSF) (DNA-binding p52/p100 complex, 100 kDa subunit).

NFH_MOUSE
NC score	0.003679 (rank : 129)	θ value	0.163984 (rank : 100)
Query Neighborhood Hits	157	Target Neighborhood Hits	2247	Shared Neighborhood Hits	49
SwissProt Accessions	P19246, Q5SVF6, Q61959	Gene names	Nefh, Nfh
Domain Architecture
Description	Neurofilament triplet H protein (200 kDa neurofilament protein) (Neurofilament heavy polypeptide) (NF-H).

K1543_MOUSE
NC score	0.003605 (rank : 130)	θ value	8.99809 (rank : 153)
Query Neighborhood Hits	157	Target Neighborhood Hits	497	Shared Neighborhood Hits	21
SwissProt Accessions	Q80VC9, Q5DTW9, Q8BUZ0	Gene names	Kiaa1543
Domain Architecture	No domain graphic available
Description	Protein KIAA1543.

CIC_HUMAN
NC score	0.003493 (rank : 131)	θ value	6.88961 (rank : 139)
Query Neighborhood Hits	157	Target Neighborhood Hits	992	Shared Neighborhood Hits	41
SwissProt Accessions	Q96RK0, Q7LGI1, Q9UEG5, Q9Y6T1	Gene names	CIC, KIAA0306
Domain Architecture	No domain graphic available
Description	Protein capicua homolog.

HUWE1_MOUSE
NC score	0.003366 (rank : 132)	θ value	3.0926 (rank : 119)
Query Neighborhood Hits	157	Target Neighborhood Hits	406	Shared Neighborhood Hits	12
SwissProt Accessions	Q7TMY8, Q4G2Z1, Q5BMM7, Q6NS61, Q8BNJ7, Q8CFH2, Q8VD14, Q921M5, Q9R0P2	Gene names	Huwe1, Kiaa0312, Ureb1
Domain Architecture	No domain graphic available
Description	HECT, UBA and WWE domain-containing protein 1 (EC 6.3.2.-) (E3 ubiquitin protein ligase URE-B1) (E3Histone).

MARE1_MOUSE
NC score	0.003258 (rank : 133)	θ value	6.88961 (rank : 145)
Query Neighborhood Hits	157	Target Neighborhood Hits	22	Shared Neighborhood Hits	3
SwissProt Accessions	Q61166, Q7TN34	Gene names	Mapre1
Domain Architecture	No domain graphic available
Description	Microtubule-associated protein RP/EB family member 1 (APC-binding protein EB1) (End-binding protein 1) (EB1).

MINT_MOUSE
NC score	0.002961 (rank : 134)	θ value	4.03905 (rank : 126)
Query Neighborhood Hits	157	Target Neighborhood Hits	1514	Shared Neighborhood Hits	38
SwissProt Accessions	Q62504, Q80TN9, Q99PS4, Q9QZW2	Gene names	Spen, Kiaa0929, Mint, Sharp
Domain Architecture
Description	Msx2-interacting protein (SPEN homolog) (SMART/HDAC1-associated repressor protein).

TSN10_MOUSE
NC score	0.002714 (rank : 135)	θ value	5.27518 (rank : 134)
Query Neighborhood Hits	157	Target Neighborhood Hits	50	Shared Neighborhood Hits	2
SwissProt Accessions	Q8VCF5	Gene names	Tspan10, Ocsp
Domain Architecture
Description	Tetraspanin-10 (Tspan-10) (Oculospanin).

HUWE1_HUMAN
NC score	0.002707 (rank : 136)	θ value	6.88961 (rank : 143)
Query Neighborhood Hits	157	Target Neighborhood Hits	443	Shared Neighborhood Hits	12
SwissProt Accessions	Q7Z6Z7, O15029, Q4G2Z2, Q5H961, Q6P4D0, Q8NG67, Q9BUI0, Q9HCJ4, Q9NSL6, Q9P0A9	Gene names	HUWE1, KIAA0312, KIAA1578, UREB1
Domain Architecture	No domain graphic available
Description	HECT, UBA and WWE domain-containing protein 1 (EC 6.3.2.-) (E3 ubiquitin protein ligase URE-B1) (Mcl-1 ubiquitin ligase E3) (Mule) (ARF-binding protein 1) (ARF-BP1).

MILK2_HUMAN
NC score	0.001409 (rank : 137)	θ value	8.99809 (rank : 154)
Query Neighborhood Hits	157	Target Neighborhood Hits	457	Shared Neighborhood Hits	15
SwissProt Accessions	Q8IY33, Q7RTP4, Q7Z655, Q8TEQ4, Q9H5F9	Gene names
Domain Architecture
Description	MICAL-like protein 2.

SEM6B_HUMAN
NC score	0.000927 (rank : 138)	θ value	2.36792 (rank : 118)
Query Neighborhood Hits	157	Target Neighborhood Hits	187	Shared Neighborhood Hits	6
SwissProt Accessions	Q9H3T3, Q9NRK9	Gene names	SEMA6B, SEMAZ
Domain Architecture
Description	Semaphorin-6B precursor (Semaphorin Z) (Sema Z).

ANK2_HUMAN
NC score	0.000724 (rank : 139)	θ value	1.38821 (rank : 107)
Query Neighborhood Hits	157	Target Neighborhood Hits	1615	Shared Neighborhood Hits	37
SwissProt Accessions	Q01484, Q01485	Gene names	ANK2
Domain Architecture
Description	Ankyrin-2 (Brain ankyrin) (Ankyrin-B) (Ankyrin, nonerythroid).

HCN2_HUMAN
NC score	0.000550 (rank : 140)	θ value	8.99809 (rank : 152)
Query Neighborhood Hits	157	Target Neighborhood Hits	369	Shared Neighborhood Hits	20
SwissProt Accessions	Q9UL51, O60742, O60743, O75267, Q9UBS2	Gene names	HCN2, BCNG2
Domain Architecture
Description	Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 (Brain cyclic nucleotide-gated channel 2) (BCNG-2).

ZYX_MOUSE
NC score	-0.000065 (rank : 141)	θ value	6.88961 (rank : 148)
Query Neighborhood Hits	157	Target Neighborhood Hits	347	Shared Neighborhood Hits	10
SwissProt Accessions	Q62523, P70461	Gene names	Zyx
Domain Architecture
Description	Zyxin.

DDX51_HUMAN
NC score	-0.000301 (rank : 142)	θ value	8.99809 (rank : 149)
Query Neighborhood Hits	157	Target Neighborhood Hits	332	Shared Neighborhood Hits	15
SwissProt Accessions	Q8N8A6, Q5CZ71, Q8IXK5, Q96ED1	Gene names	DDX51
Domain Architecture	No domain graphic available
Description	ATP-dependent RNA helicase DDX51 (EC 3.6.1.-) (DEAD box protein 51).

DDEF1_MOUSE
NC score	-0.001992 (rank : 143)	θ value	6.88961 (rank : 140)
Query Neighborhood Hits	157	Target Neighborhood Hits	592	Shared Neighborhood Hits	9
SwissProt Accessions	Q9QWY8, O08612, Q80TG8, Q80UV6, Q99LV8, Q9Z2B6	Gene names	Ddef1, Asap1, Kiaa1249, Shag1
Domain Architecture
Description	130 kDa phosphatidylinositol 4,5-biphosphate-dependent ARF1 GTPase- activating protein (PIP2-dependent ARF1 GAP) (ADP-ribosylation factor- directed GTPase-activating protein 1) (ARF GTPase-activating protein 1) (Development and differentiation-enhancing factor 1) (Differentiation-enhancing factor 1) (DEF-1).

ANK3_HUMAN
NC score	-0.002159 (rank : 144)	θ value	6.88961 (rank : 137)
Query Neighborhood Hits	157	Target Neighborhood Hits	853	Shared Neighborhood Hits	14
SwissProt Accessions	Q12955	Gene names	ANK3
Domain Architecture
Description	Ankyrin-3 (ANK-3) (Ankyrin-G).

SDK1_HUMAN
NC score	-0.003766 (rank : 145)	θ value	5.27518 (rank : 131)
Query Neighborhood Hits	157	Target Neighborhood Hits	511	Shared Neighborhood Hits	6
SwissProt Accessions	Q7Z5N4, Q8TEN9, Q8TEP5, Q96N44	Gene names	SDK1
Domain Architecture	No domain graphic available
Description	Protein sidekick-1 precursor.

PRDM2_HUMAN
NC score	-0.003928 (rank : 146)	θ value	5.27518 (rank : 130)
Query Neighborhood Hits	157	Target Neighborhood Hits	1135	Shared Neighborhood Hits	22
SwissProt Accessions	Q13029, Q13149, Q14550, Q5VUL9	Gene names	PRDM2, RIZ
Domain Architecture
Description	PR domain zinc finger protein 2 (PR domain-containing protein 2) (Retinoblastoma protein-interacting zinc-finger protein) (Zinc finger protein RIZ) (MTE-binding protein) (MTB-ZF) (GATA-3-binding protein G3B).

FOG1_HUMAN
NC score	-0.004996 (rank : 147)	θ value	6.88961 (rank : 142)
Query Neighborhood Hits	157	Target Neighborhood Hits	981	Shared Neighborhood Hits	28
SwissProt Accessions	Q8IX07	Gene names	ZFPM1, FOG1
Domain Architecture	No domain graphic available
Description	Zinc finger protein ZFPM1 (Zinc finger protein multitype 1) (Friend of GATA protein 1) (Friend of GATA-1) (FOG-1).

ZBTB9_MOUSE
NC score	-0.006204 (rank : 148)	θ value	4.03905 (rank : 128)
Query Neighborhood Hits	157	Target Neighborhood Hits	780	Shared Neighborhood Hits	8
SwissProt Accessions	Q8CDC7, Q3U3B2, Q9CYQ0	Gene names	Zbtb9
Domain Architecture
Description	Zinc finger and BTB domain-containing protein 9.

EGR4_HUMAN
NC score	-0.006871 (rank : 149)	θ value	8.99809 (rank : 150)
Query Neighborhood Hits	157	Target Neighborhood Hits	939	Shared Neighborhood Hits	19
SwissProt Accessions	Q05215	Gene names	EGR4
Domain Architecture
Description	Early growth response protein 4 (EGR-4) (AT133).

ZBTB4_HUMAN
NC score	-0.006964 (rank : 150)	θ value	6.88961 (rank : 147)
Query Neighborhood Hits	157	Target Neighborhood Hits	926	Shared Neighborhood Hits	14
SwissProt Accessions	Q9P1Z0, Q7Z697, Q86XJ4, Q8N4V8	Gene names	ZBTB4, KIAA1538
Domain Architecture
Description	Zinc finger and BTB domain-containing protein 4 (KAISO-like zinc finger protein 1) (KAISO-L1).

TIEG3_MOUSE
NC score	-0.007017 (rank : 151)	θ value	3.0926 (rank : 122)
Query Neighborhood Hits	157	Target Neighborhood Hits	774	Shared Neighborhood Hits	11
SwissProt Accessions	Q8K1S5, Q8BI37	Gene names	Tieg3, Tieg2b
Domain Architecture
Description	Transforming growth factor-beta-inducible early growth response protein 3 (TGFB-inducible early growth response protein 3) (TIEG-3) (TGFB-inducible early growth response protein 2b).

ZN406_HUMAN
NC score	-0.007651 (rank : 152)	θ value	5.27518 (rank : 135)
Query Neighborhood Hits	157	Target Neighborhood Hits	794	Shared Neighborhood Hits	12
SwissProt Accessions	Q9P243, Q3MIM5, Q6PJ01, Q75PJ7, Q75PJ9, Q86X64	Gene names	ZNF406, KIAA1485
Domain Architecture	No domain graphic available
Description	Zinc finger protein 406 (Protein ZFAT).

MK07_MOUSE
NC score	-0.008108 (rank : 153)	θ value	8.99809 (rank : 156)
Query Neighborhood Hits	157	Target Neighborhood Hits	1054	Shared Neighborhood Hits	17
SwissProt Accessions	Q9WVS8	Gene names	Mapk7, Erk5
Domain Architecture
Description	Mitogen-activated protein kinase 7 (EC 2.7.11.24) (Extracellular signal-regulated kinase 5) (ERK-5) (BMK1 kinase).

MK07_HUMAN
NC score	-0.008150 (rank : 154)	θ value	8.99809 (rank : 155)
Query Neighborhood Hits	157	Target Neighborhood Hits	1087	Shared Neighborhood Hits	18
SwissProt Accessions	Q13164, Q16634	Gene names	MAPK7, ERK4, ERK5, PRKM7
Domain Architecture
Description	Mitogen-activated protein kinase 7 (EC 2.7.11.24) (Extracellular signal-regulated kinase 5) (ERK-5) (ERK4) (BMK1 kinase).

SPEG_MOUSE
NC score	-0.008713 (rank : 155)	θ value	6.88961 (rank : 146)
Query Neighborhood Hits	157	Target Neighborhood Hits	1959	Shared Neighborhood Hits	37
SwissProt Accessions	Q62407, Q3TPH8, Q6P5V1, Q80TF7, Q80ZN0, Q8BZF4, Q9EQJ5	Gene names	Speg, Apeg1, Kiaa1297
Domain Architecture
Description	Striated muscle-specific serine/threonine protein kinase (EC 2.7.11.1) (Aortic preferentially expressed protein 1) (APEG-1).

TESK2_HUMAN
NC score	-0.008947 (rank : 156)	θ value	8.99809 (rank : 157)
Query Neighborhood Hits	157	Target Neighborhood Hits	851	Shared Neighborhood Hits	7
SwissProt Accessions	Q96S53, Q8N520, Q9Y3Q6	Gene names	TESK2
Domain Architecture
Description	Dual specificity testis-specific protein kinase 2 (EC 2.7.12.1) (Testicular protein kinase 2).

ABL1_HUMAN
NC score	-0.008996 (rank : 157)	θ value	6.88961 (rank : 136)
Query Neighborhood Hits	157	Target Neighborhood Hits	1220	Shared Neighborhood Hits	18
SwissProt Accessions	P00519, Q13869, Q13870, Q16133, Q45F09	Gene names	ABL1, ABL, JTK7
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase ABL1 (EC 2.7.10.2) (p150) (c- ABL) (Abelson murine leukemia viral oncogene homolog 1).