Please be patient as the page loads

Stop Image Loading/Displaying

Network neighborhood for query Sequence : NR4A3_MOUSE

For an explanation of this page, click here

NR4A3_MOUSE
SwissProt Accessions	Q9QZB6, Q9QZB5	Gene names	Nr4a3, Tec
Domain Architecture
Description	Orphan nuclear receptor NR4A3 (Orphan nuclear receptor TEC) (Translocated in extraskeletal chondrosarcoma).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

NR4A3_HUMAN
θ value	0 (rank : 1)	NC score	0.998533 (rank : 2)
Query Neighborhood Hits	127	Target Neighborhood Hits	131	Shared Neighborhood Hits	104
SwissProt Accessions	Q92570, Q12935, Q14979, Q16420, Q4VXA9, Q9UEK2, Q9UEK3	Gene names	NR4A3, CHN, CSMF, MINOR, NOR1, TEC
Domain Architecture
Description	Orphan nuclear receptor NR4A3 (Nuclear hormone receptor NOR-1) (Neuron-derived orphan receptor 1) (Mitogen-induced nuclear orphan receptor).

NR4A3_MOUSE
θ value	0 (rank : 2)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	127	Target Neighborhood Hits	127	Shared Neighborhood Hits	127
SwissProt Accessions	Q9QZB6, Q9QZB5	Gene names	Nr4a3, Tec
Domain Architecture
Description	Orphan nuclear receptor NR4A3 (Orphan nuclear receptor TEC) (Translocated in extraskeletal chondrosarcoma).

NR4A2_HUMAN
θ value	1.08415e-162 (rank : 3)	NC score	0.994897 (rank : 3)
Query Neighborhood Hits	127	Target Neighborhood Hits	120	Shared Neighborhood Hits	95
SwissProt Accessions	P43354, Q16311	Gene names	NR4A2, NOT, NURR1, TINUR
Domain Architecture
Description	Orphan nuclear receptor NR4A2 (Orphan nuclear receptor NURR1) (Immediate-early response protein NOT) (Transcriptionally-inducible nuclear receptor).

NR4A2_MOUSE
θ value	7.02726e-162 (rank : 4)	NC score	0.994870 (rank : 4)
Query Neighborhood Hits	127	Target Neighborhood Hits	121	Shared Neighborhood Hits	95
SwissProt Accessions	Q06219, O08690	Gene names	Nr4a2, Nurr1
Domain Architecture
Description	Orphan nuclear receptor NR4A2 (Orphan nuclear receptor NURR1) (NUR- related factor 1).

NR4A1_HUMAN
θ value	2.36663e-117 (rank : 5)	NC score	0.990847 (rank : 5)
Query Neighborhood Hits	127	Target Neighborhood Hits	133	Shared Neighborhood Hits	97
SwissProt Accessions	P22736	Gene names	NR4A1, GFRP1, HMR, NAK1
Domain Architecture
Description	Orphan nuclear receptor NR4A1 (Orphan nuclear receptor HMR) (Early response protein NAK1) (TR3 orphan receptor) (ST-59).

NR4A1_MOUSE
θ value	1.21547e-113 (rank : 6)	NC score	0.990755 (rank : 6)
Query Neighborhood Hits	127	Target Neighborhood Hits	128	Shared Neighborhood Hits	95
SwissProt Accessions	P12813	Gene names	Nr4a1, Gfrp, Hmr, N10, Nur77
Domain Architecture
Description	Orphan nuclear receptor NR4A1 (Orphan nuclear receptor HMR) (Nuclear hormone receptor NUR/77) (N10 nuclear protein).

RARB_MOUSE
θ value	1.788e-48 (rank : 7)	NC score	0.955934 (rank : 7)
Query Neighborhood Hits	127	Target Neighborhood Hits	109	Shared Neighborhood Hits	95
SwissProt Accessions	P22605, P11417, P22604	Gene names	Rarb, Nr1b2
Domain Architecture
Description	Retinoic acid receptor beta (RAR-beta).

RARB_HUMAN
θ value	1.51363e-47 (rank : 8)	NC score	0.955504 (rank : 8)
Query Neighborhood Hits	127	Target Neighborhood Hits	118	Shared Neighborhood Hits	94
SwissProt Accessions	P10826, P12891, Q00989, Q15298, Q9UN48	Gene names	RARB, HAP, NR1B2
Domain Architecture
Description	Retinoic acid receptor beta (RAR-beta) (RAR-epsilon) (HBV-activated protein).

RARA_HUMAN
θ value	4.40402e-47 (rank : 9)	NC score	0.955284 (rank : 11)
Query Neighborhood Hits	127	Target Neighborhood Hits	118	Shared Neighborhood Hits	94
SwissProt Accessions	P10276, P78456, Q13440, Q13441, Q9NQS0	Gene names	RARA, NR1B1
Domain Architecture
Description	Retinoic acid receptor alpha (RAR-alpha).

RARA_MOUSE
θ value	7.51208e-47 (rank : 10)	NC score	0.955341 (rank : 10)
Query Neighborhood Hits	127	Target Neighborhood Hits	113	Shared Neighborhood Hits	95
SwissProt Accessions	P11416, P22603	Gene names	Rara, Nr1b1
Domain Architecture
Description	Retinoic acid receptor alpha (RAR-alpha).

RARG1_MOUSE
θ value	5.38352e-45 (rank : 11)	NC score	0.955235 (rank : 13)
Query Neighborhood Hits	127	Target Neighborhood Hits	113	Shared Neighborhood Hits	96
SwissProt Accessions	P18911, Q91VK5	Gene names	Rarg, Nr1b3
Domain Architecture
Description	Retinoic acid receptor gamma-A (RAR-gamma-A).

RARG2_MOUSE
θ value	5.38352e-45 (rank : 12)	NC score	0.955429 (rank : 9)
Query Neighborhood Hits	127	Target Neighborhood Hits	114	Shared Neighborhood Hits	96
SwissProt Accessions	P20787	Gene names	Rarg, Nr1b3
Domain Architecture
Description	Retinoic acid receptor gamma-B (RAR-gamma-B).

RARG1_HUMAN
θ value	7.03111e-45 (rank : 13)	NC score	0.955160 (rank : 14)
Query Neighborhood Hits	127	Target Neighborhood Hits	107	Shared Neighborhood Hits	94
SwissProt Accessions	P13631	Gene names	RARG, NR1B3
Domain Architecture
Description	Retinoic acid receptor gamma-1 (RAR-gamma-1).

RARG2_HUMAN
θ value	7.03111e-45 (rank : 14)	NC score	0.955254 (rank : 12)
Query Neighborhood Hits	127	Target Neighborhood Hits	109	Shared Neighborhood Hits	94
SwissProt Accessions	P22932, Q15281	Gene names	RARG, NR1B3
Domain Architecture	No domain graphic available
Description	Retinoic acid receptor gamma-2 (RAR-gamma-2).

ERR3_HUMAN
θ value	1.46607e-42 (rank : 15)	NC score	0.951987 (rank : 15)
Query Neighborhood Hits	127	Target Neighborhood Hits	106	Shared Neighborhood Hits	94
SwissProt Accessions	P62508, O75454, O96021, Q68DA0, Q6P274, Q6PK28, Q6TS38, Q9R1F3, Q9UNJ4	Gene names	ESRRG, ERR3, ERRG2, KIAA0832, NR3B3
Domain Architecture	No domain graphic available
Description	Estrogen-related receptor gamma (Estrogen receptor-related protein 3) (ERR gamma-2).

ERR3_MOUSE
θ value	1.46607e-42 (rank : 16)	NC score	0.951987 (rank : 16)
Query Neighborhood Hits	127	Target Neighborhood Hits	106	Shared Neighborhood Hits	94
SwissProt Accessions	P62509, O75454, O96021, Q8CHC9, Q9R1F3	Gene names	Esrrg, Err3, Kiaa0832, Nr3b3
Domain Architecture	No domain graphic available
Description	Estrogen-related receptor gamma (Estrogen receptor-related protein 3).

RXRA_HUMAN
θ value	6.15952e-41 (rank : 17)	NC score	0.943911 (rank : 23)
Query Neighborhood Hits	127	Target Neighborhood Hits	223	Shared Neighborhood Hits	95
SwissProt Accessions	P19793, Q2V504	Gene names	RXRA, NR2B1
Domain Architecture
Description	Retinoic acid receptor RXR-alpha (Retinoid X receptor alpha).

RXRA_MOUSE
θ value	6.15952e-41 (rank : 18)	NC score	0.946606 (rank : 22)
Query Neighborhood Hits	127	Target Neighborhood Hits	129	Shared Neighborhood Hits	96
SwissProt Accessions	P28700	Gene names	Rxra, Nr2b1
Domain Architecture
Description	Retinoic acid receptor RXR-alpha (Retinoid X receptor alpha).

RXRG_MOUSE
θ value	1.05066e-40 (rank : 19)	NC score	0.947907 (rank : 20)
Query Neighborhood Hits	127	Target Neighborhood Hits	113	Shared Neighborhood Hits	94
SwissProt Accessions	P28705	Gene names	Rxrg, Nr2b3
Domain Architecture
Description	Retinoic acid receptor RXR-gamma (Retinoid X receptor gamma).

RXRG_HUMAN
θ value	1.79215e-40 (rank : 20)	NC score	0.947602 (rank : 21)
Query Neighborhood Hits	127	Target Neighborhood Hits	114	Shared Neighborhood Hits	94
SwissProt Accessions	P48443	Gene names	RXRG, NR2B3
Domain Architecture
Description	Retinoic acid receptor RXR-gamma (Retinoid X receptor gamma).

RXRB_HUMAN
θ value	3.05695e-40 (rank : 21)	NC score	0.940358 (rank : 26)
Query Neighborhood Hits	127	Target Neighborhood Hits	280	Shared Neighborhood Hits	103
SwissProt Accessions	P28702, P28703	Gene names	RXRB, NR2B2
Domain Architecture
Description	Retinoic acid receptor RXR-beta (Retinoid X receptor beta).

RXRB_MOUSE
θ value	2.58786e-39 (rank : 22)	NC score	0.943178 (rank : 24)
Query Neighborhood Hits	127	Target Neighborhood Hits	230	Shared Neighborhood Hits	103
SwissProt Accessions	P28704, P33243	Gene names	Rxrb, Nr2b2
Domain Architecture
Description	Retinoic acid receptor RXR-beta (Retinoid X receptor beta) (MHC class I regulatory element-binding protein H-2RIIBP).

COT1_HUMAN
θ value	2.86122e-38 (rank : 23)	NC score	0.936208 (rank : 40)
Query Neighborhood Hits	127	Target Neighborhood Hits	159	Shared Neighborhood Hits	94
SwissProt Accessions	P10589	Gene names	NR2F1, EAR3, ERBAL3, TFCOUP1
Domain Architecture
Description	COUP transcription factor 1 (COUP-TF1) (COUP-TF I) (V-ERBA-related protein EAR-3).

COT1_MOUSE
θ value	2.86122e-38 (rank : 24)	NC score	0.936514 (rank : 38)
Query Neighborhood Hits	127	Target Neighborhood Hits	160	Shared Neighborhood Hits	94
SwissProt Accessions	Q60632, Q61438	Gene names	Nr2f1, Erbal3, Tfcoup1
Domain Architecture
Description	COUP transcription factor 1 (COUP-TF1) (COUP-TF I).

ERR2_MOUSE
θ value	3.73686e-38 (rank : 25)	NC score	0.950340 (rank : 18)
Query Neighborhood Hits	127	Target Neighborhood Hits	109	Shared Neighborhood Hits	94
SwissProt Accessions	Q61539, O09067, O09146	Gene names	Esrrb, Err-2, Err2, Nr3b2
Domain Architecture
Description	Steroid hormone receptor ERR2 (Estrogen-related receptor, beta) (ERR- beta) (Estrogen receptor-like 2).

ERR2_HUMAN
θ value	8.32485e-38 (rank : 26)	NC score	0.949913 (rank : 19)
Query Neighborhood Hits	127	Target Neighborhood Hits	108	Shared Neighborhood Hits	94
SwissProt Accessions	O95718, Q9HCB4	Gene names	ESRRB, ERRB2, NR3B2
Domain Architecture
Description	Steroid hormone receptor ERR2 (Estrogen-related receptor, beta) (ERR- beta) (Estrogen receptor-like 2) (ERR beta-2).

ERR1_HUMAN
θ value	1.08726e-37 (rank : 27)	NC score	0.951110 (rank : 17)
Query Neighborhood Hits	127	Target Neighborhood Hits	157	Shared Neighborhood Hits	95
SwissProt Accessions	P11474, Q14514	Gene names	ESRRA, ERR1, ESRL1, NR3B1
Domain Architecture
Description	Steroid hormone receptor ERR1 (Estrogen-related receptor, alpha) (ERR- alpha) (Estrogen receptor-like 1).

ESR1_HUMAN
θ value	2.05049e-36 (rank : 28)	NC score	0.940007 (rank : 27)
Query Neighborhood Hits	127	Target Neighborhood Hits	105	Shared Neighborhood Hits	94
SwissProt Accessions	P03372, Q13511, Q14276, Q9NU51, Q9UDZ7, Q9UIS7	Gene names	ESR1, ESR, NR3A1
Domain Architecture
Description	Estrogen receptor (ER) (Estradiol receptor) (ER-alpha).

COT2_HUMAN
θ value	1.32909e-35 (rank : 29)	NC score	0.937225 (rank : 33)
Query Neighborhood Hits	127	Target Neighborhood Hits	135	Shared Neighborhood Hits	96
SwissProt Accessions	P24468, Q03754	Gene names	NR2F2, ARP1, TFCOUP2
Domain Architecture
Description	COUP transcription factor 2 (COUP-TF2) (COUP-TF II) (Apolipoprotein AI regulatory protein 1) (ARP-1).

COT2_MOUSE
θ value	1.32909e-35 (rank : 30)	NC score	0.937225 (rank : 34)
Query Neighborhood Hits	127	Target Neighborhood Hits	135	Shared Neighborhood Hits	96
SwissProt Accessions	P43135	Gene names	Nr2f2, Aporp1, Arp-1, Arp1, Tfcoup2
Domain Architecture
Description	COUP transcription factor 2 (COUP-TF2) (COUP-TF II) (Apolipoprotein AI regulatory protein 1) (ARP-1).

ESR1_MOUSE
θ value	2.26708e-35 (rank : 31)	NC score	0.940593 (rank : 25)
Query Neighborhood Hits	127	Target Neighborhood Hits	104	Shared Neighborhood Hits	94
SwissProt Accessions	P19785, Q9JJT5, Q9QY51, Q9QY52	Gene names	Esr1, Esr, Estr, Estra, Nr3a1
Domain Architecture
Description	Estrogen receptor (ER) (Estradiol receptor) (ER-alpha).

THA_MOUSE
θ value	1.6247e-33 (rank : 32)	NC score	0.934920 (rank : 42)
Query Neighborhood Hits	127	Target Neighborhood Hits	113	Shared Neighborhood Hits	94
SwissProt Accessions	P63058, P10685, P15827, P16416, P37241, Q63107, Q63195, Q63196, Q99146	Gene names	Thra, C-erba-alpha, Nr1a1
Domain Architecture	No domain graphic available
Description	Thyroid hormone receptor alpha (C-erbA-alpha) (c-erbA-1).

NR1H3_HUMAN
θ value	2.12192e-33 (rank : 33)	NC score	0.939385 (rank : 28)
Query Neighborhood Hits	127	Target Neighborhood Hits	104	Shared Neighborhood Hits	94
SwissProt Accessions	Q13133, Q96H87	Gene names	NR1H3, LXRA
Domain Architecture
Description	Oxysterols receptor LXR-alpha (Liver X receptor alpha) (Nuclear orphan receptor LXR-alpha).

THA_HUMAN
θ value	3.61944e-33 (rank : 34)	NC score	0.934772 (rank : 43)
Query Neighborhood Hits	127	Target Neighborhood Hits	113	Shared Neighborhood Hits	94
SwissProt Accessions	P10827, P21205, Q8N6A1, Q96H73	Gene names	THRA, ERBA1, NR1A1, THRA1
Domain Architecture
Description	Thyroid hormone receptor alpha (C-erbA-alpha) (c-erbA-1) (EAR-7) (EAR7).

EAR2_MOUSE
θ value	1.0531e-32 (rank : 35)	NC score	0.936678 (rank : 36)
Query Neighborhood Hits	127	Target Neighborhood Hits	104	Shared Neighborhood Hits	94
SwissProt Accessions	P43136, Q61504	Gene names	Nr2f6, Ear-2, Ear2, Erbal2
Domain Architecture
Description	Orphan nuclear receptor EAR-2 (V-erbA-related protein EAR-2).

THB1_HUMAN
θ value	1.79631e-32 (rank : 36)	NC score	0.928559 (rank : 52)
Query Neighborhood Hits	127	Target Neighborhood Hits	106	Shared Neighborhood Hits	95
SwissProt Accessions	P10828, Q13986	Gene names	THRB, ERBA2, NR1A2, THR1
Domain Architecture
Description	Thyroid hormone receptor beta-1.

THB2_MOUSE
θ value	4.00176e-32 (rank : 37)	NC score	0.927719 (rank : 55)
Query Neighborhood Hits	127	Target Neighborhood Hits	106	Shared Neighborhood Hits	94
SwissProt Accessions	P37244	Gene names	Thrb, C-erba-beta, Nr1a2
Domain Architecture
Description	Thyroid hormone receptor beta-2.

ESR2_HUMAN
θ value	5.22648e-32 (rank : 38)	NC score	0.937805 (rank : 32)
Query Neighborhood Hits	127	Target Neighborhood Hits	110	Shared Neighborhood Hits	94
SwissProt Accessions	Q92731, O60608, O60685, O60702, O60703, O75583, O75584, Q86Z31, Q9UEV6, Q9UHD3, Q9UQK9	Gene names	ESR2, ESTRB, NR3A2
Domain Architecture
Description	Estrogen receptor beta (ER-beta).

NR1H3_MOUSE
θ value	5.22648e-32 (rank : 39)	NC score	0.939050 (rank : 29)
Query Neighborhood Hits	127	Target Neighborhood Hits	102	Shared Neighborhood Hits	94
SwissProt Accessions	Q9Z0Y9, Q9QUH7	Gene names	Nr1h3, Lxra
Domain Architecture
Description	Oxysterols receptor LXR-alpha (Liver X receptor alpha) (Nuclear orphan receptor LXR-alpha).

THB2_HUMAN
θ value	5.22648e-32 (rank : 40)	NC score	0.928653 (rank : 51)
Query Neighborhood Hits	127	Target Neighborhood Hits	104	Shared Neighborhood Hits	95
SwissProt Accessions	P37243	Gene names	THRB, ERBA2, NR1A2, THR1
Domain Architecture	No domain graphic available
Description	Thyroid hormone receptor beta-2.

ESR2_MOUSE
θ value	8.91499e-32 (rank : 41)	NC score	0.936963 (rank : 35)
Query Neighborhood Hits	127	Target Neighborhood Hits	110	Shared Neighborhood Hits	94
SwissProt Accessions	O08537, O35635, O70519	Gene names	Esr2, Estrb, Nr3a2
Domain Architecture
Description	Estrogen receptor beta (ER-beta).

THB1_MOUSE
θ value	1.16434e-31 (rank : 42)	NC score	0.927610 (rank : 56)
Query Neighborhood Hits	127	Target Neighborhood Hits	105	Shared Neighborhood Hits	94
SwissProt Accessions	P37242	Gene names	Thrb, C-erba-beta, Nr1a2
Domain Architecture
Description	Thyroid hormone receptor beta-1.

EAR2_HUMAN
θ value	7.54701e-31 (rank : 43)	NC score	0.936325 (rank : 39)
Query Neighborhood Hits	127	Target Neighborhood Hits	106	Shared Neighborhood Hits	94
SwissProt Accessions	P10588, Q9BUE8	Gene names	NR2F6, EAR2, ERBAL2
Domain Architecture
Description	Orphan nuclear receptor EAR-2 (V-erbA-related protein EAR-2).

HNF4G_HUMAN
θ value	7.54701e-31 (rank : 44)	NC score	0.938820 (rank : 30)
Query Neighborhood Hits	127	Target Neighborhood Hits	100	Shared Neighborhood Hits	94
SwissProt Accessions	Q14541, Q9UH81, Q9UIS6	Gene names	HNF4G, NR2A2
Domain Architecture
Description	Hepatocyte nuclear factor 4-gamma (HNF-4-gamma).

HNF4G_MOUSE
θ value	1.28732e-30 (rank : 45)	NC score	0.938254 (rank : 31)
Query Neighborhood Hits	127	Target Neighborhood Hits	101	Shared Neighborhood Hits	94
SwissProt Accessions	Q9WUU6	Gene names	Hnf4g, Nr2a2
Domain Architecture
Description	Hepatocyte nuclear factor 4-gamma (HNF-4-gamma).

HNF4A_HUMAN
θ value	3.74554e-30 (rank : 46)	NC score	0.936653 (rank : 37)
Query Neighborhood Hits	127	Target Neighborhood Hits	105	Shared Neighborhood Hits	94
SwissProt Accessions	P41235, O00659, O00723, Q14540, Q92653, Q92654, Q92655, Q99864, Q9NQH0	Gene names	HNF4A, HNF4, NR2A1, TCF14
Domain Architecture
Description	Hepatocyte nuclear factor 4-alpha (HNF-4-alpha) (Transcription factor HNF-4) (Transcription factor 14).

HNF4A_MOUSE
θ value	2.05525e-28 (rank : 47)	NC score	0.936061 (rank : 41)
Query Neighborhood Hits	127	Target Neighborhood Hits	103	Shared Neighborhood Hits	94
SwissProt Accessions	P49698	Gene names	Hnf4a, Hnf-4, Hnf4, Nr2a1, Tcf14
Domain Architecture
Description	Hepatocyte nuclear factor 4-alpha (HNF-4-alpha) (Transcription factor HNF-4) (Transcription factor 14).

NR2E3_HUMAN
θ value	3.50572e-28 (rank : 48)	NC score	0.931643 (rank : 47)
Query Neighborhood Hits	127	Target Neighborhood Hits	102	Shared Neighborhood Hits	94
SwissProt Accessions	Q9Y5X4, Q9UHM4	Gene names	NR2E3, PNR, RNR
Domain Architecture
Description	Photoreceptor-specific nuclear receptor (Retina-specific nuclear receptor).

NR5A2_HUMAN
θ value	2.27234e-27 (rank : 49)	NC score	0.917601 (rank : 69)
Query Neighborhood Hits	127	Target Neighborhood Hits	112	Shared Neighborhood Hits	94
SwissProt Accessions	O00482, O95642	Gene names	NR5A2, B1F, CPF, FTF
Domain Architecture
Description	Orphan nuclear receptor NR5A2 (Alpha-1-fetoprotein transcription factor) (Hepatocytic transcription factor) (B1-binding factor) (hB1F) (CYP7A promoter-binding factor) (Liver receptor homolog 1) (LRH-1).

NR2E3_MOUSE
θ value	1.12775e-26 (rank : 50)	NC score	0.932316 (rank : 45)
Query Neighborhood Hits	127	Target Neighborhood Hits	113	Shared Neighborhood Hits	94
SwissProt Accessions	Q9QXZ7	Gene names	Nr2e3, Pnr, Rnr
Domain Architecture
Description	Photoreceptor-specific nuclear receptor (Retina-specific nuclear receptor).

PPARA_MOUSE
θ value	1.12775e-26 (rank : 51)	NC score	0.922021 (rank : 62)
Query Neighborhood Hits	127	Target Neighborhood Hits	99	Shared Neighborhood Hits	94
SwissProt Accessions	P23204	Gene names	Ppara, Nr1c1, Ppar
Domain Architecture
Description	Peroxisome proliferator-activated receptor alpha (PPAR-alpha).

PPARG_MOUSE
θ value	1.12775e-26 (rank : 52)	NC score	0.920357 (rank : 67)
Query Neighborhood Hits	127	Target Neighborhood Hits	97	Shared Neighborhood Hits	94
SwissProt Accessions	P37238	Gene names	Pparg, Nr1c3
Domain Architecture
Description	Peroxisome proliferator-activated receptor gamma (PPAR-gamma).

PPARD_HUMAN
θ value	1.92365e-26 (rank : 53)	NC score	0.921811 (rank : 63)
Query Neighborhood Hits	127	Target Neighborhood Hits	102	Shared Neighborhood Hits	94
SwissProt Accessions	Q03181, Q7Z5K0, Q9BUD4	Gene names	PPARD, NR1C2, PPARB
Domain Architecture
Description	Peroxisome proliferator-activated receptor delta (PPAR-delta) (PPAR- beta) (Nuclear hormone receptor 1) (NUC1) (NUCI).

PPARG_HUMAN
θ value	1.92365e-26 (rank : 54)	NC score	0.920407 (rank : 66)
Query Neighborhood Hits	127	Target Neighborhood Hits	97	Shared Neighborhood Hits	94
SwissProt Accessions	P37231, O00684, O00710, O14515, Q15178, Q15179, Q15180, Q15832, Q86U60, Q96J12	Gene names	PPARG, NR1C3
Domain Architecture
Description	Peroxisome proliferator-activated receptor gamma (PPAR-gamma).

PPARD_MOUSE
θ value	2.51237e-26 (rank : 55)	NC score	0.920843 (rank : 65)
Query Neighborhood Hits	127	Target Neighborhood Hits	103	Shared Neighborhood Hits	94
SwissProt Accessions	P35396, P37239	Gene names	Ppard, Nr1c2, Pparb
Domain Architecture
Description	Peroxisome proliferator-activated receptor delta (PPAR-delta) (PPAR- beta) (Nuclear hormone receptor 1) (NUC1).

NR1H2_MOUSE
θ value	9.54697e-26 (rank : 56)	NC score	0.927764 (rank : 54)
Query Neighborhood Hits	127	Target Neighborhood Hits	109	Shared Neighborhood Hits	94
SwissProt Accessions	Q60644	Gene names	Nr1h2, Lxrb, Rip15, Unr, Unr2
Domain Architecture
Description	Oxysterols receptor LXR-beta (Liver X receptor beta) (Nuclear orphan receptor LXR-beta) (Ubiquitously-expressed nuclear receptor) (Retinoid X receptor-interacting protein No.15).

NR5A2_MOUSE
θ value	1.62847e-25 (rank : 57)	NC score	0.917197 (rank : 71)
Query Neighborhood Hits	127	Target Neighborhood Hits	107	Shared Neighborhood Hits	94
SwissProt Accessions	P45448	Gene names	Nr5a2, Lrh1
Domain Architecture
Description	Orphan nuclear receptor NR5A2 (Liver receptor homolog 1) (LRH-1).

PPARA_HUMAN
θ value	1.62847e-25 (rank : 58)	NC score	0.921094 (rank : 64)
Query Neighborhood Hits	127	Target Neighborhood Hits	100	Shared Neighborhood Hits	94
SwissProt Accessions	Q07869, Q16241, Q92486, Q92689, Q9Y3N1	Gene names	PPARA, NR1C1, PPAR
Domain Architecture
Description	Peroxisome proliferator-activated receptor alpha (PPAR-alpha).

PXR_HUMAN
θ value	2.12685e-25 (rank : 59)	NC score	0.916321 (rank : 72)
Query Neighborhood Hits	127	Target Neighborhood Hits	107	Shared Neighborhood Hits	94
SwissProt Accessions	O75469, Q96AC7, Q9UJ22, Q9UJ23, Q9UJ24, Q9UJ25, Q9UJ26, Q9UJ27	Gene names	NR1I2, PXR
Domain Architecture
Description	Orphan nuclear receptor PXR (Pregnane X receptor) (Orphan nuclear receptor PAR1) (Steroid and xenobiotic receptor) (SXR).

NR2E1_MOUSE
θ value	8.08199e-25 (rank : 60)	NC score	0.931711 (rank : 46)
Query Neighborhood Hits	127	Target Neighborhood Hits	106	Shared Neighborhood Hits	94
SwissProt Accessions	Q64104	Gene names	Nr2e1, Tll, Tlx
Domain Architecture
Description	Orphan nuclear receptor NR2E1 (Nuclear receptor TLX) (Tailless homolog) (Tll) (mTll).

STF1_HUMAN
θ value	1.37858e-24 (rank : 61)	NC score	0.924431 (rank : 59)
Query Neighborhood Hits	127	Target Neighborhood Hits	132	Shared Neighborhood Hits	96
SwissProt Accessions	Q13285, O15196	Gene names	NR5A1, AD4BP, FTZF1, SF1
Domain Architecture
Description	Steroidogenic factor 1 (STF-1) (SF-1) (Adrenal 4-binding protein) (Steroid hormone receptor Ad4BP) (Fushi tarazu factor homolog 1).

STF1_MOUSE
θ value	1.37858e-24 (rank : 62)	NC score	0.923600 (rank : 60)
Query Neighborhood Hits	127	Target Neighborhood Hits	137	Shared Neighborhood Hits	95
SwissProt Accessions	P33242	Gene names	Nr5a1, Ftzf1
Domain Architecture
Description	Steroidogenic factor 1 (STF-1) (SF-1) (Adrenal 4-binding protein) (Steroid hormone receptor Ad4BP) (Fushi tarazu factor homolog 1) (Embryonal LTR-binding protein) (ELP) (Embryonal long terminal repeat- binding protein) (Steroid hydroxylase positive regulator).

NR2E1_HUMAN
θ value	8.93572e-24 (rank : 63)	NC score	0.930126 (rank : 50)
Query Neighborhood Hits	127	Target Neighborhood Hits	103	Shared Neighborhood Hits	94
SwissProt Accessions	Q9Y466	Gene names	NR2E1, TLX
Domain Architecture
Description	Orphan nuclear receptor NR2E1 (Nuclear receptor TLX) (Tailless homolog) (Tll) (hTll).

NR1H4_MOUSE
θ value	5.79196e-23 (rank : 64)	NC score	0.930892 (rank : 49)
Query Neighborhood Hits	127	Target Neighborhood Hits	113	Shared Neighborhood Hits	95
SwissProt Accessions	Q60641, Q60642, Q60643	Gene names	Nr1h4, Bar, Fxr, Rip14
Domain Architecture
Description	Bile acid receptor (Farnesoid X-activated receptor) (Farnesol receptor HRR-1) (Retinoid X receptor-interacting protein 14) (RXR-interacting protein 14).

NR1H4_HUMAN
θ value	7.56453e-23 (rank : 65)	NC score	0.931531 (rank : 48)
Query Neighborhood Hits	127	Target Neighborhood Hits	112	Shared Neighborhood Hits	96
SwissProt Accessions	Q96RI1, Q8NFP5, Q8NFP6, Q92943	Gene names	NR1H4, BAR, FXR, HRR1, RIP14
Domain Architecture
Description	Bile acid receptor (Farnesoid X-activated receptor) (Farnesol receptor HRR-1) (Retinoid X receptor-interacting protein 14) (RXR-interacting protein 14).

GCR_MOUSE
θ value	1.29031e-22 (rank : 66)	NC score	0.881441 (rank : 88)
Query Neighborhood Hits	127	Target Neighborhood Hits	117	Shared Neighborhood Hits	94
SwissProt Accessions	P06537, Q61628, Q61629	Gene names	Nr3c1, Grl, Grl1
Domain Architecture
Description	Glucocorticoid receptor (GR).

NR1D2_HUMAN
θ value	1.6852e-22 (rank : 67)	NC score	0.917296 (rank : 70)
Query Neighborhood Hits	127	Target Neighborhood Hits	115	Shared Neighborhood Hits	94
SwissProt Accessions	Q14995, O00402, Q86XD4	Gene names	NR1D2
Domain Architecture
Description	Orphan nuclear receptor NR1D2 (Rev-erb-beta) (EAR-1R) (Orphan nuclear hormone receptor BD73).

NR6A1_MOUSE
θ value	1.6852e-22 (rank : 68)	NC score	0.924598 (rank : 58)
Query Neighborhood Hits	127	Target Neighborhood Hits	110	Shared Neighborhood Hits	94
SwissProt Accessions	Q64249	Gene names	Nr6a1, Gcnf
Domain Architecture
Description	Orphan nuclear receptor NR6A1 (Germ cell nuclear factor) (GCNF) (Retinoid receptor-related testis-specific receptor) (RTR).

NR1D1_HUMAN
θ value	2.20094e-22 (rank : 69)	NC score	0.923211 (rank : 61)
Query Neighborhood Hits	127	Target Neighborhood Hits	140	Shared Neighborhood Hits	97
SwissProt Accessions	P20393, Q15304	Gene names	NR1D1, EAR1, HREV, THRAL
Domain Architecture
Description	Orphan nuclear receptor NR1D1 (V-erbA-related protein EAR-1) (Rev- erbA-alpha).

NR1D2_MOUSE
θ value	2.20094e-22 (rank : 70)	NC score	0.915024 (rank : 74)
Query Neighborhood Hits	127	Target Neighborhood Hits	109	Shared Neighborhood Hits	94
SwissProt Accessions	Q60674, Q60646	Gene names	Nr1d2
Domain Architecture
Description	Orphan nuclear receptor NR1D2 (Rev-erb-beta) (Orphan nuclear receptor RVR).

NR1I3_MOUSE
θ value	2.20094e-22 (rank : 71)	NC score	0.932354 (rank : 44)
Query Neighborhood Hits	127	Target Neighborhood Hits	103	Shared Neighborhood Hits	95
SwissProt Accessions	O35627, O35628	Gene names	Nr1i3, Car
Domain Architecture
Description	Orphan nuclear receptor NR1I3 (Constitutive androstane receptor) (CAR) (Orphan nuclear receptor MB67).

RORA_HUMAN
θ value	2.20094e-22 (rank : 72)	NC score	0.904275 (rank : 80)
Query Neighborhood Hits	127	Target Neighborhood Hits	105	Shared Neighborhood Hits	94
SwissProt Accessions	P35398, P35397, P35399, P45445, Q96H83	Gene names	RORA, NR1F1, RZRA
Domain Architecture
Description	Nuclear receptor ROR-alpha (Nuclear receptor RZR-alpha).

RORA_MOUSE
θ value	2.20094e-22 (rank : 73)	NC score	0.903538 (rank : 83)
Query Neighborhood Hits	127	Target Neighborhood Hits	105	Shared Neighborhood Hits	94
SwissProt Accessions	P51448, P70283, P97741, P97773, Q923G1	Gene names	Rora, Nr1f1, Rzra
Domain Architecture
Description	Nuclear receptor ROR-alpha (Nuclear receptor RZR-alpha).

RORG_HUMAN
θ value	2.87452e-22 (rank : 74)	NC score	0.902795 (rank : 84)
Query Neighborhood Hits	127	Target Neighborhood Hits	119	Shared Neighborhood Hits	94
SwissProt Accessions	P51449, Q8N5V7, Q8NCY8	Gene names	RORC, NR1F3, RORG, RZRG
Domain Architecture
Description	Nuclear receptor ROR-gamma (Nuclear receptor RZR-gamma).

TR2_MOUSE
θ value	2.87452e-22 (rank : 75)	NC score	0.905568 (rank : 79)
Query Neighborhood Hits	127	Target Neighborhood Hits	100	Shared Neighborhood Hits	94
SwissProt Accessions	Q505F1, P97763, Q3UIJ7, Q4U1Z4, Q60927, Q62152, Q8VIJ3	Gene names	Nr2c1, Tr2, Tr2-11
Domain Architecture	No domain graphic available
Description	Orphan nuclear receptor TR2 (Testicular receptor 2) (mTR2).

MCR_HUMAN
θ value	4.9032e-22 (rank : 76)	NC score	0.880092 (rank : 90)
Query Neighborhood Hits	127	Target Neighborhood Hits	149	Shared Neighborhood Hits	95
SwissProt Accessions	P08235, Q96KQ8, Q96KQ9	Gene names	NR3C2, MCR, MLR
Domain Architecture
Description	Mineralocorticoid receptor (MR).

NR6A1_HUMAN
θ value	4.9032e-22 (rank : 77)	NC score	0.924772 (rank : 57)
Query Neighborhood Hits	127	Target Neighborhood Hits	108	Shared Neighborhood Hits	94
SwissProt Accessions	Q15406, O00551, O00603, Q8NHQ0, Q92898, Q99802	Gene names	NR6A1, GCNF
Domain Architecture
Description	Orphan nuclear receptor NR6A1 (Germ cell nuclear factor) (GCNF) (Retinoid receptor-related testis-specific receptor) (RTR).

RORB_HUMAN
θ value	6.40375e-22 (rank : 78)	NC score	0.903928 (rank : 82)
Query Neighborhood Hits	127	Target Neighborhood Hits	99	Shared Neighborhood Hits	94
SwissProt Accessions	Q92753, Q8WX73	Gene names	RORB, NR1F2, RZRB
Domain Architecture
Description	Nuclear receptor ROR-beta (Nuclear receptor RZR-beta).

RORB_MOUSE
θ value	6.40375e-22 (rank : 79)	NC score	0.904129 (rank : 81)
Query Neighborhood Hits	127	Target Neighborhood Hits	99	Shared Neighborhood Hits	94
SwissProt Accessions	Q8R1B8	Gene names	Rorb, Nr1f2
Domain Architecture
Description	Nuclear receptor ROR-beta (Nuclear receptor RZR-beta).

RORG_MOUSE
θ value	8.36355e-22 (rank : 80)	NC score	0.906372 (rank : 78)
Query Neighborhood Hits	127	Target Neighborhood Hits	107	Shared Neighborhood Hits	94
SwissProt Accessions	P51450, Q61027, Q91YT5, Q9QXD9, Q9R177	Gene names	Rorc, Nr1f3, Rorg, Thor
Domain Architecture
Description	Nuclear receptor ROR-gamma (Nuclear receptor RZR-gamma) (Thymus orphan receptor) (TOR).

TR2_HUMAN
θ value	8.36355e-22 (rank : 81)	NC score	0.920145 (rank : 68)
Query Neighborhood Hits	127	Target Neighborhood Hits	110	Shared Neighborhood Hits	94
SwissProt Accessions	P13056	Gene names	NR2C1, TR2
Domain Architecture
Description	Orphan nuclear receptor TR2 (Testicular receptor 2).

TR4_HUMAN
θ value	8.36355e-22 (rank : 82)	NC score	0.900135 (rank : 85)
Query Neighborhood Hits	127	Target Neighborhood Hits	117	Shared Neighborhood Hits	94
SwissProt Accessions	P49116, P55092	Gene names	NR2C2, TAK1, TR4
Domain Architecture
Description	Orphan nuclear receptor TR4 (Orphan nuclear receptor TAK1).

ANDR_MOUSE
θ value	1.42661e-21 (rank : 83)	NC score	0.880808 (rank : 89)
Query Neighborhood Hits	127	Target Neighborhood Hits	133	Shared Neighborhood Hits	96
SwissProt Accessions	P19091	Gene names	Ar, Nr3c4
Domain Architecture
Description	Androgen receptor (Dihydrotestosterone receptor).

GCR_HUMAN
θ value	3.17815e-21 (rank : 84)	NC score	0.885712 (rank : 87)
Query Neighborhood Hits	127	Target Neighborhood Hits	113	Shared Neighborhood Hits	94
SwissProt Accessions	P04150, P04151, Q53EP5, Q6N0A4	Gene names	NR3C1, GRL
Domain Architecture
Description	Glucocorticoid receptor (GR).

TR4_MOUSE
θ value	3.17815e-21 (rank : 85)	NC score	0.899231 (rank : 86)
Query Neighborhood Hits	127	Target Neighborhood Hits	115	Shared Neighborhood Hits	94
SwissProt Accessions	P49117, P55093	Gene names	Nr2c2, Mtr2r1, Tak1, Tr4
Domain Architecture
Description	Orphan nuclear receptor TR4 (Orphan nuclear receptor TAK1).

MCR_MOUSE
θ value	1.2077e-20 (rank : 86)	NC score	0.876263 (rank : 92)
Query Neighborhood Hits	127	Target Neighborhood Hits	162	Shared Neighborhood Hits	94
SwissProt Accessions	Q8VII8, Q8VII9	Gene names	Nr3c2, Mlr
Domain Architecture	No domain graphic available
Description	Mineralocorticoid receptor (MR).

PRGR_MOUSE
θ value	2.27762e-19 (rank : 87)	NC score	0.866890 (rank : 94)
Query Neighborhood Hits	127	Target Neighborhood Hits	286	Shared Neighborhood Hits	98
SwissProt Accessions	Q00175	Gene names	Pgr, Nr3c3, Pr
Domain Architecture
Description	Progesterone receptor (PR).

NR1I3_HUMAN
θ value	2.97466e-19 (rank : 88)	NC score	0.928322 (rank : 53)
Query Neighborhood Hits	127	Target Neighborhood Hits	107	Shared Neighborhood Hits	94
SwissProt Accessions	Q14994	Gene names	NR1I3, CAR
Domain Architecture
Description	Orphan nuclear receptor NR1I3 (Constitutive androstane receptor) (CAR) (Constitutive activator of retinoid response) (Constitutive active response) (Orphan nuclear receptor MB67).

ANDR_HUMAN
θ value	6.62687e-19 (rank : 89)	NC score	0.877847 (rank : 91)
Query Neighborhood Hits	127	Target Neighborhood Hits	126	Shared Neighborhood Hits	95
SwissProt Accessions	P10275	Gene names	AR, DHTR, NR3C4
Domain Architecture
Description	Androgen receptor (Dihydrotestosterone receptor).

VDR_HUMAN
θ value	1.13037e-18 (rank : 90)	NC score	0.912824 (rank : 77)
Query Neighborhood Hits	127	Target Neighborhood Hits	112	Shared Neighborhood Hits	94
SwissProt Accessions	P11473	Gene names	VDR, NR1I1
Domain Architecture
Description	Vitamin D3 receptor (VDR) (1,25-dihydroxyvitamin D3 receptor).

PXR_MOUSE
θ value	5.60996e-18 (rank : 91)	NC score	0.913283 (rank : 76)
Query Neighborhood Hits	127	Target Neighborhood Hits	107	Shared Neighborhood Hits	94
SwissProt Accessions	O54915	Gene names	Nr1i2, Pxr
Domain Architecture
Description	Orphan nuclear receptor PXR (Pregnane X receptor).

VDR_MOUSE
θ value	5.60996e-18 (rank : 92)	NC score	0.915126 (rank : 73)
Query Neighborhood Hits	127	Target Neighborhood Hits	103	Shared Neighborhood Hits	94
SwissProt Accessions	P48281	Gene names	Vdr, Nr1i1
Domain Architecture
Description	Vitamin D3 receptor (VDR) (1,25-dihydroxyvitamin D3 receptor).

PRGR_HUMAN
θ value	7.32683e-18 (rank : 93)	NC score	0.871411 (rank : 93)
Query Neighborhood Hits	127	Target Neighborhood Hits	163	Shared Neighborhood Hits	98
SwissProt Accessions	P06401, Q9UPF7	Gene names	PGR, NR3C3
Domain Architecture
Description	Progesterone receptor (PR).

NR1H2_HUMAN
θ value	2.88119e-14 (rank : 94)	NC score	0.913817 (rank : 75)
Query Neighborhood Hits	127	Target Neighborhood Hits	114	Shared Neighborhood Hits	94
SwissProt Accessions	P55055, Q12970	Gene names	NR1H2, LXRB, NER, UNR
Domain Architecture
Description	Oxysterols receptor LXR-beta (Liver X receptor beta) (Nuclear orphan receptor LXR-beta) (Ubiquitously-expressed nuclear receptor) (Nuclear receptor NER).

CSKI1_MOUSE
θ value	0.0193708 (rank : 95)	NC score	0.012014 (rank : 106)
Query Neighborhood Hits	127	Target Neighborhood Hits	1031	Shared Neighborhood Hits	21
SwissProt Accessions	Q6P9K8, Q6ZPU2, Q8BWU2, Q8BX99, Q9CXH0	Gene names	Caskin1, Kiaa1306
Domain Architecture	No domain graphic available
Description	Caskin-1 (CASK-interacting protein 1).

TCGAP_HUMAN
θ value	0.0330416 (rank : 96)	NC score	0.013281 (rank : 103)
Query Neighborhood Hits	127	Target Neighborhood Hits	872	Shared Neighborhood Hits	16
SwissProt Accessions	O14559, O14552, O14560, Q6ZSP6, Q96CP3, Q9NT23	Gene names	SNX26, TCGAP
Domain Architecture
Description	TC10/CDC42 GTPase-activating protein (Sorting nexin-26).

CSKI1_HUMAN
θ value	0.163984 (rank : 97)	NC score	0.011759 (rank : 107)
Query Neighborhood Hits	127	Target Neighborhood Hits	997	Shared Neighborhood Hits	23
SwissProt Accessions	Q8WXD9, Q9P2P0	Gene names	CASKIN1, KIAA1306
Domain Architecture	No domain graphic available
Description	Caskin-1 (CASK-interacting protein 1).

DUT_HUMAN
θ value	0.279714 (rank : 98)	NC score	0.040148 (rank : 99)
Query Neighborhood Hits	127	Target Neighborhood Hits	52	Shared Neighborhood Hits	4
SwissProt Accessions	P33316, O14785, Q16708, Q16860, Q96Q81	Gene names	DUT
Domain Architecture
Description	Deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial precursor (EC 3.6.1.23) (dUTPase) (dUTP pyrophosphatase).

MLL3_HUMAN
θ value	0.62314 (rank : 99)	NC score	0.012087 (rank : 104)
Query Neighborhood Hits	127	Target Neighborhood Hits	1644	Shared Neighborhood Hits	27
SwissProt Accessions	Q8NEZ4, Q8NC02, Q8NDF6, Q9H9P4, Q9NR13, Q9P222, Q9UDR7	Gene names	MLL3, HALR, KIAA1506
Domain Architecture
Description	Myeloid/lymphoid or mixed-lineage leukemia protein 3 homolog (EC 2.1.1.43) (Histone-lysine N-methyltransferase, H3 lysine-4 specific MLL3) (Homologous to ALR protein).

NPAS4_HUMAN
θ value	0.813845 (rank : 100)	NC score	0.018548 (rank : 100)
Query Neighborhood Hits	127	Target Neighborhood Hits	214	Shared Neighborhood Hits	8
SwissProt Accessions	Q8IUM7, Q8N8S5, Q8N9Q9	Gene names	NPAS4, NXF
Domain Architecture	No domain graphic available
Description	Neuronal PAS domain-containing protein 4 (Neuronal PAS4) (HLH-PAS transcription factor NXF).

ZF276_HUMAN
θ value	0.813845 (rank : 101)	NC score	-0.006062 (rank : 129)
Query Neighborhood Hits	127	Target Neighborhood Hits	768	Shared Neighborhood Hits	5
SwissProt Accessions	Q8N554	Gene names	ZFP276
Domain Architecture	No domain graphic available
Description	Zinc finger protein 276 homolog (Zfp-276).

ZIMP7_MOUSE
θ value	1.38821 (rank : 102)	NC score	0.010104 (rank : 109)
Query Neighborhood Hits	127	Target Neighborhood Hits	566	Shared Neighborhood Hits	16
SwissProt Accessions	Q8CIE2, Q6P558, Q6P9Q5, Q8BJ00	Gene names	Zimp7, D11Bwg0280e
Domain Architecture	No domain graphic available
Description	PIAS-like protein Zimp7.

PTN4_HUMAN
θ value	1.81305 (rank : 103)	NC score	-0.000496 (rank : 122)
Query Neighborhood Hits	127	Target Neighborhood Hits	303	Shared Neighborhood Hits	5
SwissProt Accessions	P29074	Gene names	PTPN4
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 4 (EC 3.1.3.48) (Protein-tyrosine phosphatase MEG1) (PTPase-MEG1) (MEG).

TPO_MOUSE
θ value	1.81305 (rank : 104)	NC score	0.015230 (rank : 101)
Query Neighborhood Hits	127	Target Neighborhood Hits	258	Shared Neighborhood Hits	9
SwissProt Accessions	P40226	Gene names	Thpo
Domain Architecture
Description	Thrombopoietin precursor (Megakaryocyte colony-stimulating factor) (Myeloproliferative leukemia virus oncogene ligand) (C-mpl ligand) (ML) (Megakaryocyte growth and development factor) (MGDF).

K0174_HUMAN
θ value	2.36792 (rank : 105)	NC score	0.010761 (rank : 108)
Query Neighborhood Hits	127	Target Neighborhood Hits	37	Shared Neighborhood Hits	4
SwissProt Accessions	P53990, Q9BQ81, Q9BWN2	Gene names	KIAA0174
Domain Architecture
Description	Protein KIAA0174 (Putative MAPK-activating protein PM28).

BCAR1_HUMAN
θ value	3.0926 (rank : 106)	NC score	0.004864 (rank : 115)
Query Neighborhood Hits	127	Target Neighborhood Hits	554	Shared Neighborhood Hits	12
SwissProt Accessions	P56945	Gene names	BCAR1, CAS, CRKAS
Domain Architecture
Description	Breast cancer anti-estrogen resistance protein 1 (CRK-associated substrate) (p130cas).

EPHB3_MOUSE
θ value	3.0926 (rank : 107)	NC score	-0.006627 (rank : 130)
Query Neighborhood Hits	127	Target Neighborhood Hits	996	Shared Neighborhood Hits	6
SwissProt Accessions	P54754, Q62214	Gene names	Ephb3, Etk2, Mdk5, Sek4
Domain Architecture
Description	Ephrin type-B receptor 3 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor MDK-5) (Developmental kinase 5) (SEK-4).

MAGE1_HUMAN
θ value	3.0926 (rank : 108)	NC score	0.009534 (rank : 110)
Query Neighborhood Hits	127	Target Neighborhood Hits	1389	Shared Neighborhood Hits	25
SwissProt Accessions	Q9HCI5, Q86TG0, Q8TD92, Q9H216	Gene names	MAGEE1, HCA1, KIAA1587
Domain Architecture	No domain graphic available
Description	Melanoma-associated antigen E1 (MAGE-E1 antigen) (Hepatocellular carcinoma-associated protein 1).

MYCD_MOUSE
θ value	3.0926 (rank : 109)	NC score	0.007168 (rank : 112)
Query Neighborhood Hits	127	Target Neighborhood Hits	144	Shared Neighborhood Hits	6
SwissProt Accessions	Q8VIM5, Q8C3W6, Q8VIL4	Gene names	Myocd, Bsac2, Mycd, Srfcp
Domain Architecture
Description	Myocardin (SRF cofactor protein) (Basic SAP coiled-coil transcription activator 2).

ZN318_MOUSE
θ value	3.0926 (rank : 110)	NC score	0.006362 (rank : 114)
Query Neighborhood Hits	127	Target Neighborhood Hits	642	Shared Neighborhood Hits	9
SwissProt Accessions	Q99PP2, Q3TZL5, Q9JJ01	Gene names	Znf318, Tzf, Zfp318
Domain Architecture	No domain graphic available
Description	Zinc finger protein 318 (Testicular zinc finger protein).

EPHB3_HUMAN
θ value	4.03905 (rank : 111)	NC score	-0.006695 (rank : 131)
Query Neighborhood Hits	127	Target Neighborhood Hits	996	Shared Neighborhood Hits	6
SwissProt Accessions	P54753, Q7Z740	Gene names	EPHB3, ETK2, HEK2
Domain Architecture
Description	Ephrin type-B receptor 3 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor HEK-2).

RTN4R_MOUSE
θ value	4.03905 (rank : 112)	NC score	-0.002243 (rank : 125)
Query Neighborhood Hits	127	Target Neighborhood Hits	293	Shared Neighborhood Hits	3
SwissProt Accessions	Q99PI8, Q80WQ1	Gene names	Rtn4r, Nogor
Domain Architecture	No domain graphic available
Description	Reticulon-4 receptor precursor (Nogo receptor) (NgR) (Nogo-66 receptor).

SUHW3_HUMAN
θ value	4.03905 (rank : 113)	NC score	-0.005226 (rank : 128)
Query Neighborhood Hits	127	Target Neighborhood Hits	695	Shared Neighborhood Hits	5
SwissProt Accessions	Q8ND82, Q9NXR3	Gene names	SUHW3
Domain Architecture	No domain graphic available
Description	Suppressor of hairy wing homolog 3.

ZN318_HUMAN
θ value	4.03905 (rank : 114)	NC score	0.008558 (rank : 111)
Query Neighborhood Hits	127	Target Neighborhood Hits	497	Shared Neighborhood Hits	6
SwissProt Accessions	Q5VUA4, O94796, Q4G0E4, Q8NEM6, Q9UNU8, Q9Y2W9	Gene names	ZNF318
Domain Architecture	No domain graphic available
Description	Zinc finger protein 318 (Endocrine regulatory protein).

ARVC_HUMAN
θ value	5.27518 (rank : 115)	NC score	0.001970 (rank : 120)
Query Neighborhood Hits	127	Target Neighborhood Hits	95	Shared Neighborhood Hits	2
SwissProt Accessions	O00192	Gene names	ARVCF
Domain Architecture
Description	Armadillo repeat protein deleted in velo-cardio-facial syndrome.

MKL1_MOUSE
θ value	5.27518 (rank : 116)	NC score	0.012068 (rank : 105)
Query Neighborhood Hits	127	Target Neighborhood Hits	667	Shared Neighborhood Hits	22
SwissProt Accessions	Q8K4J6	Gene names	Mkl1, Bsac
Domain Architecture
Description	MKL/myocardin-like protein 1 (Myocardin-related transcription factor A) (MRTF-A) (Megakaryoblastic leukemia 1 protein homolog) (Basic SAP coiled-coil transcription activator).

NPAS4_MOUSE
θ value	5.27518 (rank : 117)	NC score	0.013448 (rank : 102)
Query Neighborhood Hits	127	Target Neighborhood Hits	245	Shared Neighborhood Hits	7
SwissProt Accessions	Q8BGD7, Q3V3U3	Gene names	Npas4, Nxf
Domain Architecture	No domain graphic available
Description	Neuronal PAS domain-containing protein 4 (Neuronal PAS4) (HLH-PAS transcription factor NXF) (Limbic-enhanced PAS protein) (LE-PAS).

RGS3_MOUSE
θ value	5.27518 (rank : 118)	NC score	0.003676 (rank : 118)
Query Neighborhood Hits	127	Target Neighborhood Hits	1621	Shared Neighborhood Hits	21
SwissProt Accessions	Q9DC04, Q5SRB1, Q5SRB4, Q5SRB8, Q8CEE3, Q8VI25, Q925G9, Q9JL22, Q9JL23, Q9QXA2	Gene names	Rgs3
Domain Architecture
Description	Regulator of G-protein signaling 3 (RGS3) (C2PA).

SON_HUMAN
θ value	5.27518 (rank : 119)	NC score	0.006909 (rank : 113)
Query Neighborhood Hits	127	Target Neighborhood Hits	1568	Shared Neighborhood Hits	24
SwissProt Accessions	P18583, O14487, O95981, Q14120, Q9H7B1, Q9P070, Q9P072, Q9UKP9, Q9UPY0	Gene names	SON, C21orf50, DBP5, KIAA1019, NREBP
Domain Architecture
Description	SON protein (SON3) (Negative regulatory element-binding protein) (NRE- binding protein) (DBP-5) (Bax antagonist selected in saccharomyces 1) (BASS1).

TBX21_MOUSE
θ value	5.27518 (rank : 120)	NC score	0.001281 (rank : 121)
Query Neighborhood Hits	127	Target Neighborhood Hits	116	Shared Neighborhood Hits	6
SwissProt Accessions	Q9JKD8, Q9R0A6	Gene names	Tbx21, Tbet, Tblym
Domain Architecture	No domain graphic available
Description	T-box transcription factor TBX21 (T-box protein 21) (Transcription factor TBLYM) (T-cell-specific T-box transcription factor T-bet).

ZN516_MOUSE
θ value	5.27518 (rank : 121)	NC score	-0.005107 (rank : 127)
Query Neighborhood Hits	127	Target Neighborhood Hits	1197	Shared Neighborhood Hits	15
SwissProt Accessions	Q7TSH3	Gene names	Znf516, Kiaa0222, Zfp516
Domain Architecture
Description	Zinc finger protein 516.

CAC2D_HUMAN
θ value	6.88961 (rank : 122)	NC score	0.004455 (rank : 116)
Query Neighborhood Hits	127	Target Neighborhood Hits	32	Shared Neighborhood Hits	2
SwissProt Accessions	P54289	Gene names	CACNA2D1, CACNL2A, CCHL2A
Domain Architecture
Description	Dihydropyridine-sensitive L-type calcium channel subunits alpha- 2/delta precursor [Contains: L-type calcium channel subunit alpha-2; L-type calcium channel subunit delta].

DSG1_HUMAN
θ value	8.99809 (rank : 123)	NC score	-0.001514 (rank : 123)
Query Neighborhood Hits	127	Target Neighborhood Hits	174	Shared Neighborhood Hits	3
SwissProt Accessions	Q02413	Gene names	DSG1
Domain Architecture
Description	Desmoglein-1 precursor (Desmosomal glycoprotein 1) (DG1) (DGI) (Pemphigus foliaceus antigen).

EHMT2_MOUSE
θ value	8.99809 (rank : 124)	NC score	-0.001671 (rank : 124)
Query Neighborhood Hits	127	Target Neighborhood Hits	750	Shared Neighborhood Hits	8
SwissProt Accessions	Q9Z148, Q6PE08, Q8K4R6, Q8K4R7, Q9Z149	Gene names	Ehmt2, Bat8, G9a, Ng36
Domain Architecture
Description	Histone-lysine N-methyltransferase, H3 lysine-9 specific 3 (EC 2.1.1.43) (Histone H3-K9 methyltransferase 3) (H3-K9-HMTase 3) (Euchromatic histone-lysine N-methyltransferase 2) (HLA-B-associated transcript 8) (Protein G9a).

NELF_MOUSE
θ value	8.99809 (rank : 125)	NC score	0.004361 (rank : 117)
Query Neighborhood Hits	127	Target Neighborhood Hits	35	Shared Neighborhood Hits	3
SwissProt Accessions	Q99NF2, Q8BPT0, Q8C9R5, Q9DBF4, Q9ERZ1	Gene names	Nelf, Jac
Domain Architecture	No domain graphic available
Description	Nasal embryonic luteinizing hormone-releasing hormone factor (Nasal embryonic LHRH factor) (Juxtasynaptic attractor of caldendrin on dendritic boutons protein) (Jacob protein).

TENX_HUMAN
θ value	8.99809 (rank : 126)	NC score	-0.003785 (rank : 126)
Query Neighborhood Hits	127	Target Neighborhood Hits	789	Shared Neighborhood Hits	9
SwissProt Accessions	P22105, P78530, P78531, Q08424, Q9UMG7	Gene names	TNXB, HXBL, TNX, XB
Domain Architecture
Description	Tenascin-X precursor (TN-X) (Hexabrachion-like protein).

ZMYM3_HUMAN
θ value	8.99809 (rank : 127)	NC score	0.002445 (rank : 119)
Query Neighborhood Hits	127	Target Neighborhood Hits	223	Shared Neighborhood Hits	6
SwissProt Accessions	Q14202, O15089	Gene names	ZMYM3, DXS6673E, KIAA0385, ZNF261
Domain Architecture	No domain graphic available
Description	Zinc finger MYM-type protein 3 (Zinc finger protein 261).

DAX1_HUMAN
θ value	θ > 10 (rank : 128)	NC score	0.401227 (rank : 98)
Query Neighborhood Hits	127	Target Neighborhood Hits	65	Shared Neighborhood Hits	55
SwissProt Accessions	P51843, Q96F69	Gene names	NR0B1, AHC, DAX1
Domain Architecture
Description	Nuclear receptor 0B1 (Nuclear receptor DAX-1) (DSS-AHC critical region on the X chromosome protein 1).

DAX1_MOUSE
θ value	θ > 10 (rank : 129)	NC score	0.431914 (rank : 96)
Query Neighborhood Hits	127	Target Neighborhood Hits	70	Shared Neighborhood Hits	56
SwissProt Accessions	Q61066, O09068, O09147	Gene names	Nr0b1, Ahch, Dax1
Domain Architecture
Description	Nuclear receptor 0B1 (Nuclear receptor DAX-1).

SHP_HUMAN
θ value	θ > 10 (rank : 130)	NC score	0.440204 (rank : 95)
Query Neighborhood Hits	127	Target Neighborhood Hits	57	Shared Neighborhood Hits	52
SwissProt Accessions	Q15466, Q5QP36	Gene names	NR0B2, SHP
Domain Architecture
Description	Nuclear receptor 0B2 (Orphan nuclear receptor SHP) (Small heterodimer partner).

SHP_MOUSE
θ value	θ > 10 (rank : 131)	NC score	0.431254 (rank : 97)
Query Neighborhood Hits	127	Target Neighborhood Hits	53	Shared Neighborhood Hits	49
SwissProt Accessions	Q62227, Q53Z53	Gene names	Nr0b2, Shp
Domain Architecture
Description	Nuclear receptor 0B2 (Orphan nuclear receptor SHP) (Small heterodimer partner).

Hits sorted by NC score

NR4A3_MOUSE
NC score	0.999962 (rank : 1)	θ value	0 (rank : 2)
Query Neighborhood Hits	127	Target Neighborhood Hits	127	Shared Neighborhood Hits	127
SwissProt Accessions	Q9QZB6, Q9QZB5	Gene names	Nr4a3, Tec
Domain Architecture
Description	Orphan nuclear receptor NR4A3 (Orphan nuclear receptor TEC) (Translocated in extraskeletal chondrosarcoma).

NR4A3_HUMAN
NC score	0.998533 (rank : 2)	θ value	0 (rank : 1)
Query Neighborhood Hits	127	Target Neighborhood Hits	131	Shared Neighborhood Hits	104
SwissProt Accessions	Q92570, Q12935, Q14979, Q16420, Q4VXA9, Q9UEK2, Q9UEK3	Gene names	NR4A3, CHN, CSMF, MINOR, NOR1, TEC
Domain Architecture
Description	Orphan nuclear receptor NR4A3 (Nuclear hormone receptor NOR-1) (Neuron-derived orphan receptor 1) (Mitogen-induced nuclear orphan receptor).

NR4A2_HUMAN
NC score	0.994897 (rank : 3)	θ value	1.08415e-162 (rank : 3)
Query Neighborhood Hits	127	Target Neighborhood Hits	120	Shared Neighborhood Hits	95
SwissProt Accessions	P43354, Q16311	Gene names	NR4A2, NOT, NURR1, TINUR
Domain Architecture
Description	Orphan nuclear receptor NR4A2 (Orphan nuclear receptor NURR1) (Immediate-early response protein NOT) (Transcriptionally-inducible nuclear receptor).

NR4A2_MOUSE
NC score	0.994870 (rank : 4)	θ value	7.02726e-162 (rank : 4)
Query Neighborhood Hits	127	Target Neighborhood Hits	121	Shared Neighborhood Hits	95
SwissProt Accessions	Q06219, O08690	Gene names	Nr4a2, Nurr1
Domain Architecture
Description	Orphan nuclear receptor NR4A2 (Orphan nuclear receptor NURR1) (NUR- related factor 1).

NR4A1_HUMAN
NC score	0.990847 (rank : 5)	θ value	2.36663e-117 (rank : 5)
Query Neighborhood Hits	127	Target Neighborhood Hits	133	Shared Neighborhood Hits	97
SwissProt Accessions	P22736	Gene names	NR4A1, GFRP1, HMR, NAK1
Domain Architecture
Description	Orphan nuclear receptor NR4A1 (Orphan nuclear receptor HMR) (Early response protein NAK1) (TR3 orphan receptor) (ST-59).

NR4A1_MOUSE
NC score	0.990755 (rank : 6)	θ value	1.21547e-113 (rank : 6)
Query Neighborhood Hits	127	Target Neighborhood Hits	128	Shared Neighborhood Hits	95
SwissProt Accessions	P12813	Gene names	Nr4a1, Gfrp, Hmr, N10, Nur77
Domain Architecture
Description	Orphan nuclear receptor NR4A1 (Orphan nuclear receptor HMR) (Nuclear hormone receptor NUR/77) (N10 nuclear protein).

RARB_MOUSE
NC score	0.955934 (rank : 7)	θ value	1.788e-48 (rank : 7)
Query Neighborhood Hits	127	Target Neighborhood Hits	109	Shared Neighborhood Hits	95
SwissProt Accessions	P22605, P11417, P22604	Gene names	Rarb, Nr1b2
Domain Architecture
Description	Retinoic acid receptor beta (RAR-beta).

RARB_HUMAN
NC score	0.955504 (rank : 8)	θ value	1.51363e-47 (rank : 8)
Query Neighborhood Hits	127	Target Neighborhood Hits	118	Shared Neighborhood Hits	94
SwissProt Accessions	P10826, P12891, Q00989, Q15298, Q9UN48	Gene names	RARB, HAP, NR1B2
Domain Architecture
Description	Retinoic acid receptor beta (RAR-beta) (RAR-epsilon) (HBV-activated protein).

RARG2_MOUSE
NC score	0.955429 (rank : 9)	θ value	5.38352e-45 (rank : 12)
Query Neighborhood Hits	127	Target Neighborhood Hits	114	Shared Neighborhood Hits	96
SwissProt Accessions	P20787	Gene names	Rarg, Nr1b3
Domain Architecture
Description	Retinoic acid receptor gamma-B (RAR-gamma-B).

RARA_MOUSE
NC score	0.955341 (rank : 10)	θ value	7.51208e-47 (rank : 10)
Query Neighborhood Hits	127	Target Neighborhood Hits	113	Shared Neighborhood Hits	95
SwissProt Accessions	P11416, P22603	Gene names	Rara, Nr1b1
Domain Architecture
Description	Retinoic acid receptor alpha (RAR-alpha).

RARA_HUMAN
NC score	0.955284 (rank : 11)	θ value	4.40402e-47 (rank : 9)
Query Neighborhood Hits	127	Target Neighborhood Hits	118	Shared Neighborhood Hits	94
SwissProt Accessions	P10276, P78456, Q13440, Q13441, Q9NQS0	Gene names	RARA, NR1B1
Domain Architecture
Description	Retinoic acid receptor alpha (RAR-alpha).

RARG2_HUMAN
NC score	0.955254 (rank : 12)	θ value	7.03111e-45 (rank : 14)
Query Neighborhood Hits	127	Target Neighborhood Hits	109	Shared Neighborhood Hits	94
SwissProt Accessions	P22932, Q15281	Gene names	RARG, NR1B3
Domain Architecture	No domain graphic available
Description	Retinoic acid receptor gamma-2 (RAR-gamma-2).

RARG1_MOUSE
NC score	0.955235 (rank : 13)	θ value	5.38352e-45 (rank : 11)
Query Neighborhood Hits	127	Target Neighborhood Hits	113	Shared Neighborhood Hits	96
SwissProt Accessions	P18911, Q91VK5	Gene names	Rarg, Nr1b3
Domain Architecture
Description	Retinoic acid receptor gamma-A (RAR-gamma-A).

RARG1_HUMAN
NC score	0.955160 (rank : 14)	θ value	7.03111e-45 (rank : 13)
Query Neighborhood Hits	127	Target Neighborhood Hits	107	Shared Neighborhood Hits	94
SwissProt Accessions	P13631	Gene names	RARG, NR1B3
Domain Architecture
Description	Retinoic acid receptor gamma-1 (RAR-gamma-1).

ERR3_HUMAN
NC score	0.951987 (rank : 15)	θ value	1.46607e-42 (rank : 15)
Query Neighborhood Hits	127	Target Neighborhood Hits	106	Shared Neighborhood Hits	94
SwissProt Accessions	P62508, O75454, O96021, Q68DA0, Q6P274, Q6PK28, Q6TS38, Q9R1F3, Q9UNJ4	Gene names	ESRRG, ERR3, ERRG2, KIAA0832, NR3B3
Domain Architecture	No domain graphic available
Description	Estrogen-related receptor gamma (Estrogen receptor-related protein 3) (ERR gamma-2).

ERR3_MOUSE
NC score	0.951987 (rank : 16)	θ value	1.46607e-42 (rank : 16)
Query Neighborhood Hits	127	Target Neighborhood Hits	106	Shared Neighborhood Hits	94
SwissProt Accessions	P62509, O75454, O96021, Q8CHC9, Q9R1F3	Gene names	Esrrg, Err3, Kiaa0832, Nr3b3
Domain Architecture	No domain graphic available
Description	Estrogen-related receptor gamma (Estrogen receptor-related protein 3).

ERR1_HUMAN
NC score	0.951110 (rank : 17)	θ value	1.08726e-37 (rank : 27)
Query Neighborhood Hits	127	Target Neighborhood Hits	157	Shared Neighborhood Hits	95
SwissProt Accessions	P11474, Q14514	Gene names	ESRRA, ERR1, ESRL1, NR3B1
Domain Architecture
Description	Steroid hormone receptor ERR1 (Estrogen-related receptor, alpha) (ERR- alpha) (Estrogen receptor-like 1).

ERR2_MOUSE
NC score	0.950340 (rank : 18)	θ value	3.73686e-38 (rank : 25)
Query Neighborhood Hits	127	Target Neighborhood Hits	109	Shared Neighborhood Hits	94
SwissProt Accessions	Q61539, O09067, O09146	Gene names	Esrrb, Err-2, Err2, Nr3b2
Domain Architecture
Description	Steroid hormone receptor ERR2 (Estrogen-related receptor, beta) (ERR- beta) (Estrogen receptor-like 2).

ERR2_HUMAN
NC score	0.949913 (rank : 19)	θ value	8.32485e-38 (rank : 26)
Query Neighborhood Hits	127	Target Neighborhood Hits	108	Shared Neighborhood Hits	94
SwissProt Accessions	O95718, Q9HCB4	Gene names	ESRRB, ERRB2, NR3B2
Domain Architecture
Description	Steroid hormone receptor ERR2 (Estrogen-related receptor, beta) (ERR- beta) (Estrogen receptor-like 2) (ERR beta-2).

RXRG_MOUSE
NC score	0.947907 (rank : 20)	θ value	1.05066e-40 (rank : 19)
Query Neighborhood Hits	127	Target Neighborhood Hits	113	Shared Neighborhood Hits	94
SwissProt Accessions	P28705	Gene names	Rxrg, Nr2b3
Domain Architecture
Description	Retinoic acid receptor RXR-gamma (Retinoid X receptor gamma).

RXRG_HUMAN
NC score	0.947602 (rank : 21)	θ value	1.79215e-40 (rank : 20)
Query Neighborhood Hits	127	Target Neighborhood Hits	114	Shared Neighborhood Hits	94
SwissProt Accessions	P48443	Gene names	RXRG, NR2B3
Domain Architecture
Description	Retinoic acid receptor RXR-gamma (Retinoid X receptor gamma).

RXRA_MOUSE
NC score	0.946606 (rank : 22)	θ value	6.15952e-41 (rank : 18)
Query Neighborhood Hits	127	Target Neighborhood Hits	129	Shared Neighborhood Hits	96
SwissProt Accessions	P28700	Gene names	Rxra, Nr2b1
Domain Architecture
Description	Retinoic acid receptor RXR-alpha (Retinoid X receptor alpha).

RXRA_HUMAN
NC score	0.943911 (rank : 23)	θ value	6.15952e-41 (rank : 17)
Query Neighborhood Hits	127	Target Neighborhood Hits	223	Shared Neighborhood Hits	95
SwissProt Accessions	P19793, Q2V504	Gene names	RXRA, NR2B1
Domain Architecture
Description	Retinoic acid receptor RXR-alpha (Retinoid X receptor alpha).

RXRB_MOUSE
NC score	0.943178 (rank : 24)	θ value	2.58786e-39 (rank : 22)
Query Neighborhood Hits	127	Target Neighborhood Hits	230	Shared Neighborhood Hits	103
SwissProt Accessions	P28704, P33243	Gene names	Rxrb, Nr2b2
Domain Architecture
Description	Retinoic acid receptor RXR-beta (Retinoid X receptor beta) (MHC class I regulatory element-binding protein H-2RIIBP).

ESR1_MOUSE
NC score	0.940593 (rank : 25)	θ value	2.26708e-35 (rank : 31)
Query Neighborhood Hits	127	Target Neighborhood Hits	104	Shared Neighborhood Hits	94
SwissProt Accessions	P19785, Q9JJT5, Q9QY51, Q9QY52	Gene names	Esr1, Esr, Estr, Estra, Nr3a1
Domain Architecture
Description	Estrogen receptor (ER) (Estradiol receptor) (ER-alpha).

RXRB_HUMAN
NC score	0.940358 (rank : 26)	θ value	3.05695e-40 (rank : 21)
Query Neighborhood Hits	127	Target Neighborhood Hits	280	Shared Neighborhood Hits	103
SwissProt Accessions	P28702, P28703	Gene names	RXRB, NR2B2
Domain Architecture
Description	Retinoic acid receptor RXR-beta (Retinoid X receptor beta).

ESR1_HUMAN
NC score	0.940007 (rank : 27)	θ value	2.05049e-36 (rank : 28)
Query Neighborhood Hits	127	Target Neighborhood Hits	105	Shared Neighborhood Hits	94
SwissProt Accessions	P03372, Q13511, Q14276, Q9NU51, Q9UDZ7, Q9UIS7	Gene names	ESR1, ESR, NR3A1
Domain Architecture
Description	Estrogen receptor (ER) (Estradiol receptor) (ER-alpha).

NR1H3_HUMAN
NC score	0.939385 (rank : 28)	θ value	2.12192e-33 (rank : 33)
Query Neighborhood Hits	127	Target Neighborhood Hits	104	Shared Neighborhood Hits	94
SwissProt Accessions	Q13133, Q96H87	Gene names	NR1H3, LXRA
Domain Architecture
Description	Oxysterols receptor LXR-alpha (Liver X receptor alpha) (Nuclear orphan receptor LXR-alpha).

NR1H3_MOUSE
NC score	0.939050 (rank : 29)	θ value	5.22648e-32 (rank : 39)
Query Neighborhood Hits	127	Target Neighborhood Hits	102	Shared Neighborhood Hits	94
SwissProt Accessions	Q9Z0Y9, Q9QUH7	Gene names	Nr1h3, Lxra
Domain Architecture
Description	Oxysterols receptor LXR-alpha (Liver X receptor alpha) (Nuclear orphan receptor LXR-alpha).

HNF4G_HUMAN
NC score	0.938820 (rank : 30)	θ value	7.54701e-31 (rank : 44)
Query Neighborhood Hits	127	Target Neighborhood Hits	100	Shared Neighborhood Hits	94
SwissProt Accessions	Q14541, Q9UH81, Q9UIS6	Gene names	HNF4G, NR2A2
Domain Architecture
Description	Hepatocyte nuclear factor 4-gamma (HNF-4-gamma).

HNF4G_MOUSE
NC score	0.938254 (rank : 31)	θ value	1.28732e-30 (rank : 45)
Query Neighborhood Hits	127	Target Neighborhood Hits	101	Shared Neighborhood Hits	94
SwissProt Accessions	Q9WUU6	Gene names	Hnf4g, Nr2a2
Domain Architecture
Description	Hepatocyte nuclear factor 4-gamma (HNF-4-gamma).

ESR2_HUMAN
NC score	0.937805 (rank : 32)	θ value	5.22648e-32 (rank : 38)
Query Neighborhood Hits	127	Target Neighborhood Hits	110	Shared Neighborhood Hits	94
SwissProt Accessions	Q92731, O60608, O60685, O60702, O60703, O75583, O75584, Q86Z31, Q9UEV6, Q9UHD3, Q9UQK9	Gene names	ESR2, ESTRB, NR3A2
Domain Architecture
Description	Estrogen receptor beta (ER-beta).

COT2_HUMAN
NC score	0.937225 (rank : 33)	θ value	1.32909e-35 (rank : 29)
Query Neighborhood Hits	127	Target Neighborhood Hits	135	Shared Neighborhood Hits	96
SwissProt Accessions	P24468, Q03754	Gene names	NR2F2, ARP1, TFCOUP2
Domain Architecture
Description	COUP transcription factor 2 (COUP-TF2) (COUP-TF II) (Apolipoprotein AI regulatory protein 1) (ARP-1).

COT2_MOUSE
NC score	0.937225 (rank : 34)	θ value	1.32909e-35 (rank : 30)
Query Neighborhood Hits	127	Target Neighborhood Hits	135	Shared Neighborhood Hits	96
SwissProt Accessions	P43135	Gene names	Nr2f2, Aporp1, Arp-1, Arp1, Tfcoup2
Domain Architecture
Description	COUP transcription factor 2 (COUP-TF2) (COUP-TF II) (Apolipoprotein AI regulatory protein 1) (ARP-1).

ESR2_MOUSE
NC score	0.936963 (rank : 35)	θ value	8.91499e-32 (rank : 41)
Query Neighborhood Hits	127	Target Neighborhood Hits	110	Shared Neighborhood Hits	94
SwissProt Accessions	O08537, O35635, O70519	Gene names	Esr2, Estrb, Nr3a2
Domain Architecture
Description	Estrogen receptor beta (ER-beta).

EAR2_MOUSE
NC score	0.936678 (rank : 36)	θ value	1.0531e-32 (rank : 35)
Query Neighborhood Hits	127	Target Neighborhood Hits	104	Shared Neighborhood Hits	94
SwissProt Accessions	P43136, Q61504	Gene names	Nr2f6, Ear-2, Ear2, Erbal2
Domain Architecture
Description	Orphan nuclear receptor EAR-2 (V-erbA-related protein EAR-2).

HNF4A_HUMAN
NC score	0.936653 (rank : 37)	θ value	3.74554e-30 (rank : 46)
Query Neighborhood Hits	127	Target Neighborhood Hits	105	Shared Neighborhood Hits	94
SwissProt Accessions	P41235, O00659, O00723, Q14540, Q92653, Q92654, Q92655, Q99864, Q9NQH0	Gene names	HNF4A, HNF4, NR2A1, TCF14
Domain Architecture
Description	Hepatocyte nuclear factor 4-alpha (HNF-4-alpha) (Transcription factor HNF-4) (Transcription factor 14).

COT1_MOUSE
NC score	0.936514 (rank : 38)	θ value	2.86122e-38 (rank : 24)
Query Neighborhood Hits	127	Target Neighborhood Hits	160	Shared Neighborhood Hits	94
SwissProt Accessions	Q60632, Q61438	Gene names	Nr2f1, Erbal3, Tfcoup1
Domain Architecture
Description	COUP transcription factor 1 (COUP-TF1) (COUP-TF I).

EAR2_HUMAN
NC score	0.936325 (rank : 39)	θ value	7.54701e-31 (rank : 43)
Query Neighborhood Hits	127	Target Neighborhood Hits	106	Shared Neighborhood Hits	94
SwissProt Accessions	P10588, Q9BUE8	Gene names	NR2F6, EAR2, ERBAL2
Domain Architecture
Description	Orphan nuclear receptor EAR-2 (V-erbA-related protein EAR-2).

COT1_HUMAN
NC score	0.936208 (rank : 40)	θ value	2.86122e-38 (rank : 23)
Query Neighborhood Hits	127	Target Neighborhood Hits	159	Shared Neighborhood Hits	94
SwissProt Accessions	P10589	Gene names	NR2F1, EAR3, ERBAL3, TFCOUP1
Domain Architecture
Description	COUP transcription factor 1 (COUP-TF1) (COUP-TF I) (V-ERBA-related protein EAR-3).

HNF4A_MOUSE
NC score	0.936061 (rank : 41)	θ value	2.05525e-28 (rank : 47)
Query Neighborhood Hits	127	Target Neighborhood Hits	103	Shared Neighborhood Hits	94
SwissProt Accessions	P49698	Gene names	Hnf4a, Hnf-4, Hnf4, Nr2a1, Tcf14
Domain Architecture
Description	Hepatocyte nuclear factor 4-alpha (HNF-4-alpha) (Transcription factor HNF-4) (Transcription factor 14).

THA_MOUSE
NC score	0.934920 (rank : 42)	θ value	1.6247e-33 (rank : 32)
Query Neighborhood Hits	127	Target Neighborhood Hits	113	Shared Neighborhood Hits	94
SwissProt Accessions	P63058, P10685, P15827, P16416, P37241, Q63107, Q63195, Q63196, Q99146	Gene names	Thra, C-erba-alpha, Nr1a1
Domain Architecture	No domain graphic available
Description	Thyroid hormone receptor alpha (C-erbA-alpha) (c-erbA-1).

THA_HUMAN
NC score	0.934772 (rank : 43)	θ value	3.61944e-33 (rank : 34)
Query Neighborhood Hits	127	Target Neighborhood Hits	113	Shared Neighborhood Hits	94
SwissProt Accessions	P10827, P21205, Q8N6A1, Q96H73	Gene names	THRA, ERBA1, NR1A1, THRA1
Domain Architecture
Description	Thyroid hormone receptor alpha (C-erbA-alpha) (c-erbA-1) (EAR-7) (EAR7).

NR1I3_MOUSE
NC score	0.932354 (rank : 44)	θ value	2.20094e-22 (rank : 71)
Query Neighborhood Hits	127	Target Neighborhood Hits	103	Shared Neighborhood Hits	95
SwissProt Accessions	O35627, O35628	Gene names	Nr1i3, Car
Domain Architecture
Description	Orphan nuclear receptor NR1I3 (Constitutive androstane receptor) (CAR) (Orphan nuclear receptor MB67).

NR2E3_MOUSE
NC score	0.932316 (rank : 45)	θ value	1.12775e-26 (rank : 50)
Query Neighborhood Hits	127	Target Neighborhood Hits	113	Shared Neighborhood Hits	94
SwissProt Accessions	Q9QXZ7	Gene names	Nr2e3, Pnr, Rnr
Domain Architecture
Description	Photoreceptor-specific nuclear receptor (Retina-specific nuclear receptor).

NR2E1_MOUSE
NC score	0.931711 (rank : 46)	θ value	8.08199e-25 (rank : 60)
Query Neighborhood Hits	127	Target Neighborhood Hits	106	Shared Neighborhood Hits	94
SwissProt Accessions	Q64104	Gene names	Nr2e1, Tll, Tlx
Domain Architecture
Description	Orphan nuclear receptor NR2E1 (Nuclear receptor TLX) (Tailless homolog) (Tll) (mTll).

NR2E3_HUMAN
NC score	0.931643 (rank : 47)	θ value	3.50572e-28 (rank : 48)
Query Neighborhood Hits	127	Target Neighborhood Hits	102	Shared Neighborhood Hits	94
SwissProt Accessions	Q9Y5X4, Q9UHM4	Gene names	NR2E3, PNR, RNR
Domain Architecture
Description	Photoreceptor-specific nuclear receptor (Retina-specific nuclear receptor).

NR1H4_HUMAN
NC score	0.931531 (rank : 48)	θ value	7.56453e-23 (rank : 65)
Query Neighborhood Hits	127	Target Neighborhood Hits	112	Shared Neighborhood Hits	96
SwissProt Accessions	Q96RI1, Q8NFP5, Q8NFP6, Q92943	Gene names	NR1H4, BAR, FXR, HRR1, RIP14
Domain Architecture
Description	Bile acid receptor (Farnesoid X-activated receptor) (Farnesol receptor HRR-1) (Retinoid X receptor-interacting protein 14) (RXR-interacting protein 14).

NR1H4_MOUSE
NC score	0.930892 (rank : 49)	θ value	5.79196e-23 (rank : 64)
Query Neighborhood Hits	127	Target Neighborhood Hits	113	Shared Neighborhood Hits	95
SwissProt Accessions	Q60641, Q60642, Q60643	Gene names	Nr1h4, Bar, Fxr, Rip14
Domain Architecture
Description	Bile acid receptor (Farnesoid X-activated receptor) (Farnesol receptor HRR-1) (Retinoid X receptor-interacting protein 14) (RXR-interacting protein 14).

NR2E1_HUMAN
NC score	0.930126 (rank : 50)	θ value	8.93572e-24 (rank : 63)
Query Neighborhood Hits	127	Target Neighborhood Hits	103	Shared Neighborhood Hits	94
SwissProt Accessions	Q9Y466	Gene names	NR2E1, TLX
Domain Architecture
Description	Orphan nuclear receptor NR2E1 (Nuclear receptor TLX) (Tailless homolog) (Tll) (hTll).

THB2_HUMAN
NC score	0.928653 (rank : 51)	θ value	5.22648e-32 (rank : 40)
Query Neighborhood Hits	127	Target Neighborhood Hits	104	Shared Neighborhood Hits	95
SwissProt Accessions	P37243	Gene names	THRB, ERBA2, NR1A2, THR1
Domain Architecture	No domain graphic available
Description	Thyroid hormone receptor beta-2.

THB1_HUMAN
NC score	0.928559 (rank : 52)	θ value	1.79631e-32 (rank : 36)
Query Neighborhood Hits	127	Target Neighborhood Hits	106	Shared Neighborhood Hits	95
SwissProt Accessions	P10828, Q13986	Gene names	THRB, ERBA2, NR1A2, THR1
Domain Architecture
Description	Thyroid hormone receptor beta-1.

NR1I3_HUMAN
NC score	0.928322 (rank : 53)	θ value	2.97466e-19 (rank : 88)
Query Neighborhood Hits	127	Target Neighborhood Hits	107	Shared Neighborhood Hits	94
SwissProt Accessions	Q14994	Gene names	NR1I3, CAR
Domain Architecture
Description	Orphan nuclear receptor NR1I3 (Constitutive androstane receptor) (CAR) (Constitutive activator of retinoid response) (Constitutive active response) (Orphan nuclear receptor MB67).

NR1H2_MOUSE
NC score	0.927764 (rank : 54)	θ value	9.54697e-26 (rank : 56)
Query Neighborhood Hits	127	Target Neighborhood Hits	109	Shared Neighborhood Hits	94
SwissProt Accessions	Q60644	Gene names	Nr1h2, Lxrb, Rip15, Unr, Unr2
Domain Architecture
Description	Oxysterols receptor LXR-beta (Liver X receptor beta) (Nuclear orphan receptor LXR-beta) (Ubiquitously-expressed nuclear receptor) (Retinoid X receptor-interacting protein No.15).

THB2_MOUSE
NC score	0.927719 (rank : 55)	θ value	4.00176e-32 (rank : 37)
Query Neighborhood Hits	127	Target Neighborhood Hits	106	Shared Neighborhood Hits	94
SwissProt Accessions	P37244	Gene names	Thrb, C-erba-beta, Nr1a2
Domain Architecture
Description	Thyroid hormone receptor beta-2.

THB1_MOUSE
NC score	0.927610 (rank : 56)	θ value	1.16434e-31 (rank : 42)
Query Neighborhood Hits	127	Target Neighborhood Hits	105	Shared Neighborhood Hits	94
SwissProt Accessions	P37242	Gene names	Thrb, C-erba-beta, Nr1a2
Domain Architecture
Description	Thyroid hormone receptor beta-1.

NR6A1_HUMAN
NC score	0.924772 (rank : 57)	θ value	4.9032e-22 (rank : 77)
Query Neighborhood Hits	127	Target Neighborhood Hits	108	Shared Neighborhood Hits	94
SwissProt Accessions	Q15406, O00551, O00603, Q8NHQ0, Q92898, Q99802	Gene names	NR6A1, GCNF
Domain Architecture
Description	Orphan nuclear receptor NR6A1 (Germ cell nuclear factor) (GCNF) (Retinoid receptor-related testis-specific receptor) (RTR).

NR6A1_MOUSE
NC score	0.924598 (rank : 58)	θ value	1.6852e-22 (rank : 68)
Query Neighborhood Hits	127	Target Neighborhood Hits	110	Shared Neighborhood Hits	94
SwissProt Accessions	Q64249	Gene names	Nr6a1, Gcnf
Domain Architecture
Description	Orphan nuclear receptor NR6A1 (Germ cell nuclear factor) (GCNF) (Retinoid receptor-related testis-specific receptor) (RTR).

STF1_HUMAN
NC score	0.924431 (rank : 59)	θ value	1.37858e-24 (rank : 61)
Query Neighborhood Hits	127	Target Neighborhood Hits	132	Shared Neighborhood Hits	96
SwissProt Accessions	Q13285, O15196	Gene names	NR5A1, AD4BP, FTZF1, SF1
Domain Architecture
Description	Steroidogenic factor 1 (STF-1) (SF-1) (Adrenal 4-binding protein) (Steroid hormone receptor Ad4BP) (Fushi tarazu factor homolog 1).

STF1_MOUSE
NC score	0.923600 (rank : 60)	θ value	1.37858e-24 (rank : 62)
Query Neighborhood Hits	127	Target Neighborhood Hits	137	Shared Neighborhood Hits	95
SwissProt Accessions	P33242	Gene names	Nr5a1, Ftzf1
Domain Architecture
Description	Steroidogenic factor 1 (STF-1) (SF-1) (Adrenal 4-binding protein) (Steroid hormone receptor Ad4BP) (Fushi tarazu factor homolog 1) (Embryonal LTR-binding protein) (ELP) (Embryonal long terminal repeat- binding protein) (Steroid hydroxylase positive regulator).

NR1D1_HUMAN
NC score	0.923211 (rank : 61)	θ value	2.20094e-22 (rank : 69)
Query Neighborhood Hits	127	Target Neighborhood Hits	140	Shared Neighborhood Hits	97
SwissProt Accessions	P20393, Q15304	Gene names	NR1D1, EAR1, HREV, THRAL
Domain Architecture
Description	Orphan nuclear receptor NR1D1 (V-erbA-related protein EAR-1) (Rev- erbA-alpha).

PPARA_MOUSE
NC score	0.922021 (rank : 62)	θ value	1.12775e-26 (rank : 51)
Query Neighborhood Hits	127	Target Neighborhood Hits	99	Shared Neighborhood Hits	94
SwissProt Accessions	P23204	Gene names	Ppara, Nr1c1, Ppar
Domain Architecture
Description	Peroxisome proliferator-activated receptor alpha (PPAR-alpha).

PPARD_HUMAN
NC score	0.921811 (rank : 63)	θ value	1.92365e-26 (rank : 53)
Query Neighborhood Hits	127	Target Neighborhood Hits	102	Shared Neighborhood Hits	94
SwissProt Accessions	Q03181, Q7Z5K0, Q9BUD4	Gene names	PPARD, NR1C2, PPARB
Domain Architecture
Description	Peroxisome proliferator-activated receptor delta (PPAR-delta) (PPAR- beta) (Nuclear hormone receptor 1) (NUC1) (NUCI).

PPARA_HUMAN
NC score	0.921094 (rank : 64)	θ value	1.62847e-25 (rank : 58)
Query Neighborhood Hits	127	Target Neighborhood Hits	100	Shared Neighborhood Hits	94
SwissProt Accessions	Q07869, Q16241, Q92486, Q92689, Q9Y3N1	Gene names	PPARA, NR1C1, PPAR
Domain Architecture
Description	Peroxisome proliferator-activated receptor alpha (PPAR-alpha).

PPARD_MOUSE
NC score	0.920843 (rank : 65)	θ value	2.51237e-26 (rank : 55)
Query Neighborhood Hits	127	Target Neighborhood Hits	103	Shared Neighborhood Hits	94
SwissProt Accessions	P35396, P37239	Gene names	Ppard, Nr1c2, Pparb
Domain Architecture
Description	Peroxisome proliferator-activated receptor delta (PPAR-delta) (PPAR- beta) (Nuclear hormone receptor 1) (NUC1).

PPARG_HUMAN
NC score	0.920407 (rank : 66)	θ value	1.92365e-26 (rank : 54)
Query Neighborhood Hits	127	Target Neighborhood Hits	97	Shared Neighborhood Hits	94
SwissProt Accessions	P37231, O00684, O00710, O14515, Q15178, Q15179, Q15180, Q15832, Q86U60, Q96J12	Gene names	PPARG, NR1C3
Domain Architecture
Description	Peroxisome proliferator-activated receptor gamma (PPAR-gamma).

PPARG_MOUSE
NC score	0.920357 (rank : 67)	θ value	1.12775e-26 (rank : 52)
Query Neighborhood Hits	127	Target Neighborhood Hits	97	Shared Neighborhood Hits	94
SwissProt Accessions	P37238	Gene names	Pparg, Nr1c3
Domain Architecture
Description	Peroxisome proliferator-activated receptor gamma (PPAR-gamma).

TR2_HUMAN
NC score	0.920145 (rank : 68)	θ value	8.36355e-22 (rank : 81)
Query Neighborhood Hits	127	Target Neighborhood Hits	110	Shared Neighborhood Hits	94
SwissProt Accessions	P13056	Gene names	NR2C1, TR2
Domain Architecture
Description	Orphan nuclear receptor TR2 (Testicular receptor 2).

NR5A2_HUMAN
NC score	0.917601 (rank : 69)	θ value	2.27234e-27 (rank : 49)
Query Neighborhood Hits	127	Target Neighborhood Hits	112	Shared Neighborhood Hits	94
SwissProt Accessions	O00482, O95642	Gene names	NR5A2, B1F, CPF, FTF
Domain Architecture
Description	Orphan nuclear receptor NR5A2 (Alpha-1-fetoprotein transcription factor) (Hepatocytic transcription factor) (B1-binding factor) (hB1F) (CYP7A promoter-binding factor) (Liver receptor homolog 1) (LRH-1).

NR1D2_HUMAN
NC score	0.917296 (rank : 70)	θ value	1.6852e-22 (rank : 67)
Query Neighborhood Hits	127	Target Neighborhood Hits	115	Shared Neighborhood Hits	94
SwissProt Accessions	Q14995, O00402, Q86XD4	Gene names	NR1D2
Domain Architecture
Description	Orphan nuclear receptor NR1D2 (Rev-erb-beta) (EAR-1R) (Orphan nuclear hormone receptor BD73).

NR5A2_MOUSE
NC score	0.917197 (rank : 71)	θ value	1.62847e-25 (rank : 57)
Query Neighborhood Hits	127	Target Neighborhood Hits	107	Shared Neighborhood Hits	94
SwissProt Accessions	P45448	Gene names	Nr5a2, Lrh1
Domain Architecture
Description	Orphan nuclear receptor NR5A2 (Liver receptor homolog 1) (LRH-1).

PXR_HUMAN
NC score	0.916321 (rank : 72)	θ value	2.12685e-25 (rank : 59)
Query Neighborhood Hits	127	Target Neighborhood Hits	107	Shared Neighborhood Hits	94
SwissProt Accessions	O75469, Q96AC7, Q9UJ22, Q9UJ23, Q9UJ24, Q9UJ25, Q9UJ26, Q9UJ27	Gene names	NR1I2, PXR
Domain Architecture
Description	Orphan nuclear receptor PXR (Pregnane X receptor) (Orphan nuclear receptor PAR1) (Steroid and xenobiotic receptor) (SXR).

VDR_MOUSE
NC score	0.915126 (rank : 73)	θ value	5.60996e-18 (rank : 92)
Query Neighborhood Hits	127	Target Neighborhood Hits	103	Shared Neighborhood Hits	94
SwissProt Accessions	P48281	Gene names	Vdr, Nr1i1
Domain Architecture
Description	Vitamin D3 receptor (VDR) (1,25-dihydroxyvitamin D3 receptor).

NR1D2_MOUSE
NC score	0.915024 (rank : 74)	θ value	2.20094e-22 (rank : 70)
Query Neighborhood Hits	127	Target Neighborhood Hits	109	Shared Neighborhood Hits	94
SwissProt Accessions	Q60674, Q60646	Gene names	Nr1d2
Domain Architecture
Description	Orphan nuclear receptor NR1D2 (Rev-erb-beta) (Orphan nuclear receptor RVR).

NR1H2_HUMAN
NC score	0.913817 (rank : 75)	θ value	2.88119e-14 (rank : 94)
Query Neighborhood Hits	127	Target Neighborhood Hits	114	Shared Neighborhood Hits	94
SwissProt Accessions	P55055, Q12970	Gene names	NR1H2, LXRB, NER, UNR
Domain Architecture
Description	Oxysterols receptor LXR-beta (Liver X receptor beta) (Nuclear orphan receptor LXR-beta) (Ubiquitously-expressed nuclear receptor) (Nuclear receptor NER).

PXR_MOUSE
NC score	0.913283 (rank : 76)	θ value	5.60996e-18 (rank : 91)
Query Neighborhood Hits	127	Target Neighborhood Hits	107	Shared Neighborhood Hits	94
SwissProt Accessions	O54915	Gene names	Nr1i2, Pxr
Domain Architecture
Description	Orphan nuclear receptor PXR (Pregnane X receptor).

VDR_HUMAN
NC score	0.912824 (rank : 77)	θ value	1.13037e-18 (rank : 90)
Query Neighborhood Hits	127	Target Neighborhood Hits	112	Shared Neighborhood Hits	94
SwissProt Accessions	P11473	Gene names	VDR, NR1I1
Domain Architecture
Description	Vitamin D3 receptor (VDR) (1,25-dihydroxyvitamin D3 receptor).

RORG_MOUSE
NC score	0.906372 (rank : 78)	θ value	8.36355e-22 (rank : 80)
Query Neighborhood Hits	127	Target Neighborhood Hits	107	Shared Neighborhood Hits	94
SwissProt Accessions	P51450, Q61027, Q91YT5, Q9QXD9, Q9R177	Gene names	Rorc, Nr1f3, Rorg, Thor
Domain Architecture
Description	Nuclear receptor ROR-gamma (Nuclear receptor RZR-gamma) (Thymus orphan receptor) (TOR).

TR2_MOUSE
NC score	0.905568 (rank : 79)	θ value	2.87452e-22 (rank : 75)
Query Neighborhood Hits	127	Target Neighborhood Hits	100	Shared Neighborhood Hits	94
SwissProt Accessions	Q505F1, P97763, Q3UIJ7, Q4U1Z4, Q60927, Q62152, Q8VIJ3	Gene names	Nr2c1, Tr2, Tr2-11
Domain Architecture	No domain graphic available
Description	Orphan nuclear receptor TR2 (Testicular receptor 2) (mTR2).

RORA_HUMAN
NC score	0.904275 (rank : 80)	θ value	2.20094e-22 (rank : 72)
Query Neighborhood Hits	127	Target Neighborhood Hits	105	Shared Neighborhood Hits	94
SwissProt Accessions	P35398, P35397, P35399, P45445, Q96H83	Gene names	RORA, NR1F1, RZRA
Domain Architecture
Description	Nuclear receptor ROR-alpha (Nuclear receptor RZR-alpha).

RORB_MOUSE
NC score	0.904129 (rank : 81)	θ value	6.40375e-22 (rank : 79)
Query Neighborhood Hits	127	Target Neighborhood Hits	99	Shared Neighborhood Hits	94
SwissProt Accessions	Q8R1B8	Gene names	Rorb, Nr1f2
Domain Architecture
Description	Nuclear receptor ROR-beta (Nuclear receptor RZR-beta).

RORB_HUMAN
NC score	0.903928 (rank : 82)	θ value	6.40375e-22 (rank : 78)
Query Neighborhood Hits	127	Target Neighborhood Hits	99	Shared Neighborhood Hits	94
SwissProt Accessions	Q92753, Q8WX73	Gene names	RORB, NR1F2, RZRB
Domain Architecture
Description	Nuclear receptor ROR-beta (Nuclear receptor RZR-beta).

RORA_MOUSE
NC score	0.903538 (rank : 83)	θ value	2.20094e-22 (rank : 73)
Query Neighborhood Hits	127	Target Neighborhood Hits	105	Shared Neighborhood Hits	94
SwissProt Accessions	P51448, P70283, P97741, P97773, Q923G1	Gene names	Rora, Nr1f1, Rzra
Domain Architecture
Description	Nuclear receptor ROR-alpha (Nuclear receptor RZR-alpha).

RORG_HUMAN
NC score	0.902795 (rank : 84)	θ value	2.87452e-22 (rank : 74)
Query Neighborhood Hits	127	Target Neighborhood Hits	119	Shared Neighborhood Hits	94
SwissProt Accessions	P51449, Q8N5V7, Q8NCY8	Gene names	RORC, NR1F3, RORG, RZRG
Domain Architecture
Description	Nuclear receptor ROR-gamma (Nuclear receptor RZR-gamma).

TR4_HUMAN
NC score	0.900135 (rank : 85)	θ value	8.36355e-22 (rank : 82)
Query Neighborhood Hits	127	Target Neighborhood Hits	117	Shared Neighborhood Hits	94
SwissProt Accessions	P49116, P55092	Gene names	NR2C2, TAK1, TR4
Domain Architecture
Description	Orphan nuclear receptor TR4 (Orphan nuclear receptor TAK1).

TR4_MOUSE
NC score	0.899231 (rank : 86)	θ value	3.17815e-21 (rank : 85)
Query Neighborhood Hits	127	Target Neighborhood Hits	115	Shared Neighborhood Hits	94
SwissProt Accessions	P49117, P55093	Gene names	Nr2c2, Mtr2r1, Tak1, Tr4
Domain Architecture
Description	Orphan nuclear receptor TR4 (Orphan nuclear receptor TAK1).

GCR_HUMAN
NC score	0.885712 (rank : 87)	θ value	3.17815e-21 (rank : 84)
Query Neighborhood Hits	127	Target Neighborhood Hits	113	Shared Neighborhood Hits	94
SwissProt Accessions	P04150, P04151, Q53EP5, Q6N0A4	Gene names	NR3C1, GRL
Domain Architecture
Description	Glucocorticoid receptor (GR).

GCR_MOUSE
NC score	0.881441 (rank : 88)	θ value	1.29031e-22 (rank : 66)
Query Neighborhood Hits	127	Target Neighborhood Hits	117	Shared Neighborhood Hits	94
SwissProt Accessions	P06537, Q61628, Q61629	Gene names	Nr3c1, Grl, Grl1
Domain Architecture
Description	Glucocorticoid receptor (GR).

ANDR_MOUSE
NC score	0.880808 (rank : 89)	θ value	1.42661e-21 (rank : 83)
Query Neighborhood Hits	127	Target Neighborhood Hits	133	Shared Neighborhood Hits	96
SwissProt Accessions	P19091	Gene names	Ar, Nr3c4
Domain Architecture
Description	Androgen receptor (Dihydrotestosterone receptor).

MCR_HUMAN
NC score	0.880092 (rank : 90)	θ value	4.9032e-22 (rank : 76)
Query Neighborhood Hits	127	Target Neighborhood Hits	149	Shared Neighborhood Hits	95
SwissProt Accessions	P08235, Q96KQ8, Q96KQ9	Gene names	NR3C2, MCR, MLR
Domain Architecture
Description	Mineralocorticoid receptor (MR).

ANDR_HUMAN
NC score	0.877847 (rank : 91)	θ value	6.62687e-19 (rank : 89)
Query Neighborhood Hits	127	Target Neighborhood Hits	126	Shared Neighborhood Hits	95
SwissProt Accessions	P10275	Gene names	AR, DHTR, NR3C4
Domain Architecture
Description	Androgen receptor (Dihydrotestosterone receptor).

MCR_MOUSE
NC score	0.876263 (rank : 92)	θ value	1.2077e-20 (rank : 86)
Query Neighborhood Hits	127	Target Neighborhood Hits	162	Shared Neighborhood Hits	94
SwissProt Accessions	Q8VII8, Q8VII9	Gene names	Nr3c2, Mlr
Domain Architecture	No domain graphic available
Description	Mineralocorticoid receptor (MR).

PRGR_HUMAN
NC score	0.871411 (rank : 93)	θ value	7.32683e-18 (rank : 93)
Query Neighborhood Hits	127	Target Neighborhood Hits	163	Shared Neighborhood Hits	98
SwissProt Accessions	P06401, Q9UPF7	Gene names	PGR, NR3C3
Domain Architecture
Description	Progesterone receptor (PR).

PRGR_MOUSE
NC score	0.866890 (rank : 94)	θ value	2.27762e-19 (rank : 87)
Query Neighborhood Hits	127	Target Neighborhood Hits	286	Shared Neighborhood Hits	98
SwissProt Accessions	Q00175	Gene names	Pgr, Nr3c3, Pr
Domain Architecture
Description	Progesterone receptor (PR).

SHP_HUMAN
NC score	0.440204 (rank : 95)	θ value	θ > 10 (rank : 130)
Query Neighborhood Hits	127	Target Neighborhood Hits	57	Shared Neighborhood Hits	52
SwissProt Accessions	Q15466, Q5QP36	Gene names	NR0B2, SHP
Domain Architecture
Description	Nuclear receptor 0B2 (Orphan nuclear receptor SHP) (Small heterodimer partner).

DAX1_MOUSE
NC score	0.431914 (rank : 96)	θ value	θ > 10 (rank : 129)
Query Neighborhood Hits	127	Target Neighborhood Hits	70	Shared Neighborhood Hits	56
SwissProt Accessions	Q61066, O09068, O09147	Gene names	Nr0b1, Ahch, Dax1
Domain Architecture
Description	Nuclear receptor 0B1 (Nuclear receptor DAX-1).

SHP_MOUSE
NC score	0.431254 (rank : 97)	θ value	θ > 10 (rank : 131)
Query Neighborhood Hits	127	Target Neighborhood Hits	53	Shared Neighborhood Hits	49
SwissProt Accessions	Q62227, Q53Z53	Gene names	Nr0b2, Shp
Domain Architecture
Description	Nuclear receptor 0B2 (Orphan nuclear receptor SHP) (Small heterodimer partner).

DAX1_HUMAN
NC score	0.401227 (rank : 98)	θ value	θ > 10 (rank : 128)
Query Neighborhood Hits	127	Target Neighborhood Hits	65	Shared Neighborhood Hits	55
SwissProt Accessions	P51843, Q96F69	Gene names	NR0B1, AHC, DAX1
Domain Architecture
Description	Nuclear receptor 0B1 (Nuclear receptor DAX-1) (DSS-AHC critical region on the X chromosome protein 1).

DUT_HUMAN
NC score	0.040148 (rank : 99)	θ value	0.279714 (rank : 98)
Query Neighborhood Hits	127	Target Neighborhood Hits	52	Shared Neighborhood Hits	4
SwissProt Accessions	P33316, O14785, Q16708, Q16860, Q96Q81	Gene names	DUT
Domain Architecture
Description	Deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial precursor (EC 3.6.1.23) (dUTPase) (dUTP pyrophosphatase).

NPAS4_HUMAN
NC score	0.018548 (rank : 100)	θ value	0.813845 (rank : 100)
Query Neighborhood Hits	127	Target Neighborhood Hits	214	Shared Neighborhood Hits	8
SwissProt Accessions	Q8IUM7, Q8N8S5, Q8N9Q9	Gene names	NPAS4, NXF
Domain Architecture	No domain graphic available
Description	Neuronal PAS domain-containing protein 4 (Neuronal PAS4) (HLH-PAS transcription factor NXF).

TPO_MOUSE
NC score	0.015230 (rank : 101)	θ value	1.81305 (rank : 104)
Query Neighborhood Hits	127	Target Neighborhood Hits	258	Shared Neighborhood Hits	9
SwissProt Accessions	P40226	Gene names	Thpo
Domain Architecture
Description	Thrombopoietin precursor (Megakaryocyte colony-stimulating factor) (Myeloproliferative leukemia virus oncogene ligand) (C-mpl ligand) (ML) (Megakaryocyte growth and development factor) (MGDF).

NPAS4_MOUSE
NC score	0.013448 (rank : 102)	θ value	5.27518 (rank : 117)
Query Neighborhood Hits	127	Target Neighborhood Hits	245	Shared Neighborhood Hits	7
SwissProt Accessions	Q8BGD7, Q3V3U3	Gene names	Npas4, Nxf
Domain Architecture	No domain graphic available
Description	Neuronal PAS domain-containing protein 4 (Neuronal PAS4) (HLH-PAS transcription factor NXF) (Limbic-enhanced PAS protein) (LE-PAS).

TCGAP_HUMAN
NC score	0.013281 (rank : 103)	θ value	0.0330416 (rank : 96)
Query Neighborhood Hits	127	Target Neighborhood Hits	872	Shared Neighborhood Hits	16
SwissProt Accessions	O14559, O14552, O14560, Q6ZSP6, Q96CP3, Q9NT23	Gene names	SNX26, TCGAP
Domain Architecture
Description	TC10/CDC42 GTPase-activating protein (Sorting nexin-26).

MLL3_HUMAN
NC score	0.012087 (rank : 104)	θ value	0.62314 (rank : 99)
Query Neighborhood Hits	127	Target Neighborhood Hits	1644	Shared Neighborhood Hits	27
SwissProt Accessions	Q8NEZ4, Q8NC02, Q8NDF6, Q9H9P4, Q9NR13, Q9P222, Q9UDR7	Gene names	MLL3, HALR, KIAA1506
Domain Architecture
Description	Myeloid/lymphoid or mixed-lineage leukemia protein 3 homolog (EC 2.1.1.43) (Histone-lysine N-methyltransferase, H3 lysine-4 specific MLL3) (Homologous to ALR protein).

MKL1_MOUSE
NC score	0.012068 (rank : 105)	θ value	5.27518 (rank : 116)
Query Neighborhood Hits	127	Target Neighborhood Hits	667	Shared Neighborhood Hits	22
SwissProt Accessions	Q8K4J6	Gene names	Mkl1, Bsac
Domain Architecture
Description	MKL/myocardin-like protein 1 (Myocardin-related transcription factor A) (MRTF-A) (Megakaryoblastic leukemia 1 protein homolog) (Basic SAP coiled-coil transcription activator).

CSKI1_MOUSE
NC score	0.012014 (rank : 106)	θ value	0.0193708 (rank : 95)
Query Neighborhood Hits	127	Target Neighborhood Hits	1031	Shared Neighborhood Hits	21
SwissProt Accessions	Q6P9K8, Q6ZPU2, Q8BWU2, Q8BX99, Q9CXH0	Gene names	Caskin1, Kiaa1306
Domain Architecture	No domain graphic available
Description	Caskin-1 (CASK-interacting protein 1).

CSKI1_HUMAN
NC score	0.011759 (rank : 107)	θ value	0.163984 (rank : 97)
Query Neighborhood Hits	127	Target Neighborhood Hits	997	Shared Neighborhood Hits	23
SwissProt Accessions	Q8WXD9, Q9P2P0	Gene names	CASKIN1, KIAA1306
Domain Architecture	No domain graphic available
Description	Caskin-1 (CASK-interacting protein 1).

K0174_HUMAN
NC score	0.010761 (rank : 108)	θ value	2.36792 (rank : 105)
Query Neighborhood Hits	127	Target Neighborhood Hits	37	Shared Neighborhood Hits	4
SwissProt Accessions	P53990, Q9BQ81, Q9BWN2	Gene names	KIAA0174
Domain Architecture
Description	Protein KIAA0174 (Putative MAPK-activating protein PM28).

ZIMP7_MOUSE
NC score	0.010104 (rank : 109)	θ value	1.38821 (rank : 102)
Query Neighborhood Hits	127	Target Neighborhood Hits	566	Shared Neighborhood Hits	16
SwissProt Accessions	Q8CIE2, Q6P558, Q6P9Q5, Q8BJ00	Gene names	Zimp7, D11Bwg0280e
Domain Architecture	No domain graphic available
Description	PIAS-like protein Zimp7.

MAGE1_HUMAN
NC score	0.009534 (rank : 110)	θ value	3.0926 (rank : 108)
Query Neighborhood Hits	127	Target Neighborhood Hits	1389	Shared Neighborhood Hits	25
SwissProt Accessions	Q9HCI5, Q86TG0, Q8TD92, Q9H216	Gene names	MAGEE1, HCA1, KIAA1587
Domain Architecture	No domain graphic available
Description	Melanoma-associated antigen E1 (MAGE-E1 antigen) (Hepatocellular carcinoma-associated protein 1).

ZN318_HUMAN
NC score	0.008558 (rank : 111)	θ value	4.03905 (rank : 114)
Query Neighborhood Hits	127	Target Neighborhood Hits	497	Shared Neighborhood Hits	6
SwissProt Accessions	Q5VUA4, O94796, Q4G0E4, Q8NEM6, Q9UNU8, Q9Y2W9	Gene names	ZNF318
Domain Architecture	No domain graphic available
Description	Zinc finger protein 318 (Endocrine regulatory protein).

MYCD_MOUSE
NC score	0.007168 (rank : 112)	θ value	3.0926 (rank : 109)
Query Neighborhood Hits	127	Target Neighborhood Hits	144	Shared Neighborhood Hits	6
SwissProt Accessions	Q8VIM5, Q8C3W6, Q8VIL4	Gene names	Myocd, Bsac2, Mycd, Srfcp
Domain Architecture
Description	Myocardin (SRF cofactor protein) (Basic SAP coiled-coil transcription activator 2).

SON_HUMAN
NC score	0.006909 (rank : 113)	θ value	5.27518 (rank : 119)
Query Neighborhood Hits	127	Target Neighborhood Hits	1568	Shared Neighborhood Hits	24
SwissProt Accessions	P18583, O14487, O95981, Q14120, Q9H7B1, Q9P070, Q9P072, Q9UKP9, Q9UPY0	Gene names	SON, C21orf50, DBP5, KIAA1019, NREBP
Domain Architecture
Description	SON protein (SON3) (Negative regulatory element-binding protein) (NRE- binding protein) (DBP-5) (Bax antagonist selected in saccharomyces 1) (BASS1).

ZN318_MOUSE
NC score	0.006362 (rank : 114)	θ value	3.0926 (rank : 110)
Query Neighborhood Hits	127	Target Neighborhood Hits	642	Shared Neighborhood Hits	9
SwissProt Accessions	Q99PP2, Q3TZL5, Q9JJ01	Gene names	Znf318, Tzf, Zfp318
Domain Architecture	No domain graphic available
Description	Zinc finger protein 318 (Testicular zinc finger protein).

BCAR1_HUMAN
NC score	0.004864 (rank : 115)	θ value	3.0926 (rank : 106)
Query Neighborhood Hits	127	Target Neighborhood Hits	554	Shared Neighborhood Hits	12
SwissProt Accessions	P56945	Gene names	BCAR1, CAS, CRKAS
Domain Architecture
Description	Breast cancer anti-estrogen resistance protein 1 (CRK-associated substrate) (p130cas).

CAC2D_HUMAN
NC score	0.004455 (rank : 116)	θ value	6.88961 (rank : 122)
Query Neighborhood Hits	127	Target Neighborhood Hits	32	Shared Neighborhood Hits	2
SwissProt Accessions	P54289	Gene names	CACNA2D1, CACNL2A, CCHL2A
Domain Architecture
Description	Dihydropyridine-sensitive L-type calcium channel subunits alpha- 2/delta precursor [Contains: L-type calcium channel subunit alpha-2; L-type calcium channel subunit delta].

NELF_MOUSE
NC score	0.004361 (rank : 117)	θ value	8.99809 (rank : 125)
Query Neighborhood Hits	127	Target Neighborhood Hits	35	Shared Neighborhood Hits	3
SwissProt Accessions	Q99NF2, Q8BPT0, Q8C9R5, Q9DBF4, Q9ERZ1	Gene names	Nelf, Jac
Domain Architecture	No domain graphic available
Description	Nasal embryonic luteinizing hormone-releasing hormone factor (Nasal embryonic LHRH factor) (Juxtasynaptic attractor of caldendrin on dendritic boutons protein) (Jacob protein).

RGS3_MOUSE
NC score	0.003676 (rank : 118)	θ value	5.27518 (rank : 118)
Query Neighborhood Hits	127	Target Neighborhood Hits	1621	Shared Neighborhood Hits	21
SwissProt Accessions	Q9DC04, Q5SRB1, Q5SRB4, Q5SRB8, Q8CEE3, Q8VI25, Q925G9, Q9JL22, Q9JL23, Q9QXA2	Gene names	Rgs3
Domain Architecture
Description	Regulator of G-protein signaling 3 (RGS3) (C2PA).

ZMYM3_HUMAN
NC score	0.002445 (rank : 119)	θ value	8.99809 (rank : 127)
Query Neighborhood Hits	127	Target Neighborhood Hits	223	Shared Neighborhood Hits	6
SwissProt Accessions	Q14202, O15089	Gene names	ZMYM3, DXS6673E, KIAA0385, ZNF261
Domain Architecture	No domain graphic available
Description	Zinc finger MYM-type protein 3 (Zinc finger protein 261).

ARVC_HUMAN
NC score	0.001970 (rank : 120)	θ value	5.27518 (rank : 115)
Query Neighborhood Hits	127	Target Neighborhood Hits	95	Shared Neighborhood Hits	2
SwissProt Accessions	O00192	Gene names	ARVCF
Domain Architecture
Description	Armadillo repeat protein deleted in velo-cardio-facial syndrome.

TBX21_MOUSE
NC score	0.001281 (rank : 121)	θ value	5.27518 (rank : 120)
Query Neighborhood Hits	127	Target Neighborhood Hits	116	Shared Neighborhood Hits	6
SwissProt Accessions	Q9JKD8, Q9R0A6	Gene names	Tbx21, Tbet, Tblym
Domain Architecture	No domain graphic available
Description	T-box transcription factor TBX21 (T-box protein 21) (Transcription factor TBLYM) (T-cell-specific T-box transcription factor T-bet).

PTN4_HUMAN
NC score	-0.000496 (rank : 122)	θ value	1.81305 (rank : 103)
Query Neighborhood Hits	127	Target Neighborhood Hits	303	Shared Neighborhood Hits	5
SwissProt Accessions	P29074	Gene names	PTPN4
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 4 (EC 3.1.3.48) (Protein-tyrosine phosphatase MEG1) (PTPase-MEG1) (MEG).

DSG1_HUMAN
NC score	-0.001514 (rank : 123)	θ value	8.99809 (rank : 123)
Query Neighborhood Hits	127	Target Neighborhood Hits	174	Shared Neighborhood Hits	3
SwissProt Accessions	Q02413	Gene names	DSG1
Domain Architecture
Description	Desmoglein-1 precursor (Desmosomal glycoprotein 1) (DG1) (DGI) (Pemphigus foliaceus antigen).

EHMT2_MOUSE
NC score	-0.001671 (rank : 124)	θ value	8.99809 (rank : 124)
Query Neighborhood Hits	127	Target Neighborhood Hits	750	Shared Neighborhood Hits	8
SwissProt Accessions	Q9Z148, Q6PE08, Q8K4R6, Q8K4R7, Q9Z149	Gene names	Ehmt2, Bat8, G9a, Ng36
Domain Architecture
Description	Histone-lysine N-methyltransferase, H3 lysine-9 specific 3 (EC 2.1.1.43) (Histone H3-K9 methyltransferase 3) (H3-K9-HMTase 3) (Euchromatic histone-lysine N-methyltransferase 2) (HLA-B-associated transcript 8) (Protein G9a).

RTN4R_MOUSE
NC score	-0.002243 (rank : 125)	θ value	4.03905 (rank : 112)
Query Neighborhood Hits	127	Target Neighborhood Hits	293	Shared Neighborhood Hits	3
SwissProt Accessions	Q99PI8, Q80WQ1	Gene names	Rtn4r, Nogor
Domain Architecture	No domain graphic available
Description	Reticulon-4 receptor precursor (Nogo receptor) (NgR) (Nogo-66 receptor).

TENX_HUMAN
NC score	-0.003785 (rank : 126)	θ value	8.99809 (rank : 126)
Query Neighborhood Hits	127	Target Neighborhood Hits	789	Shared Neighborhood Hits	9
SwissProt Accessions	P22105, P78530, P78531, Q08424, Q9UMG7	Gene names	TNXB, HXBL, TNX, XB
Domain Architecture
Description	Tenascin-X precursor (TN-X) (Hexabrachion-like protein).

ZN516_MOUSE
NC score	-0.005107 (rank : 127)	θ value	5.27518 (rank : 121)
Query Neighborhood Hits	127	Target Neighborhood Hits	1197	Shared Neighborhood Hits	15
SwissProt Accessions	Q7TSH3	Gene names	Znf516, Kiaa0222, Zfp516
Domain Architecture
Description	Zinc finger protein 516.

SUHW3_HUMAN
NC score	-0.005226 (rank : 128)	θ value	4.03905 (rank : 113)
Query Neighborhood Hits	127	Target Neighborhood Hits	695	Shared Neighborhood Hits	5
SwissProt Accessions	Q8ND82, Q9NXR3	Gene names	SUHW3
Domain Architecture	No domain graphic available
Description	Suppressor of hairy wing homolog 3.

ZF276_HUMAN
NC score	-0.006062 (rank : 129)	θ value	0.813845 (rank : 101)
Query Neighborhood Hits	127	Target Neighborhood Hits	768	Shared Neighborhood Hits	5
SwissProt Accessions	Q8N554	Gene names	ZFP276
Domain Architecture	No domain graphic available
Description	Zinc finger protein 276 homolog (Zfp-276).

EPHB3_MOUSE
NC score	-0.006627 (rank : 130)	θ value	3.0926 (rank : 107)
Query Neighborhood Hits	127	Target Neighborhood Hits	996	Shared Neighborhood Hits	6
SwissProt Accessions	P54754, Q62214	Gene names	Ephb3, Etk2, Mdk5, Sek4
Domain Architecture
Description	Ephrin type-B receptor 3 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor MDK-5) (Developmental kinase 5) (SEK-4).

EPHB3_HUMAN
NC score	-0.006695 (rank : 131)	θ value	4.03905 (rank : 111)
Query Neighborhood Hits	127	Target Neighborhood Hits	996	Shared Neighborhood Hits	6
SwissProt Accessions	P54753, Q7Z740	Gene names	EPHB3, ETK2, HEK2
Domain Architecture
Description	Ephrin type-B receptor 3 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor HEK-2).