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Network neighborhood for query Sequence : SYMPK_HUMAN

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SYMPK_HUMAN
SwissProt Accessions	Q92797, O00521, O00689, O00733, Q59GT5, Q8N2U5	Gene names	SYMPK, SPK
Domain Architecture	No domain graphic available
Description	Symplekin.
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

SYMPK_HUMAN
θ value	0 (rank : 1)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	90	Target Neighborhood Hits	90	Shared Neighborhood Hits	90
SwissProt Accessions	Q92797, O00521, O00689, O00733, Q59GT5, Q8N2U5	Gene names	SYMPK, SPK
Domain Architecture	No domain graphic available
Description	Symplekin.

SYMPK_MOUSE
θ value	0 (rank : 2)	NC score	0.978265 (rank : 2)
Query Neighborhood Hits	90	Target Neighborhood Hits	109	Shared Neighborhood Hits	49
SwissProt Accessions	Q80X82	Gene names	Sympk
Domain Architecture	No domain graphic available
Description	Symplekin.

OGFR_HUMAN
θ value	0.000461057 (rank : 3)	NC score	0.058798 (rank : 11)
Query Neighborhood Hits	90	Target Neighborhood Hits	1582	Shared Neighborhood Hits	28
SwissProt Accessions	Q9NZT2, O96029, Q4VXW5, Q96CM2, Q9BQW1, Q9H4H0, Q9H7J5, Q9NZT3, Q9NZT4	Gene names	OGFR
Domain Architecture
Description	Opioid growth factor receptor (OGFr) (Zeta-type opioid receptor) (7-60 protein).

DNJCD_HUMAN
θ value	0.0113563 (rank : 4)	NC score	0.119356 (rank : 3)
Query Neighborhood Hits	90	Target Neighborhood Hits	87	Shared Neighborhood Hits	5
SwissProt Accessions	O75165, Q6PI82, Q6UJ77, Q6ZSW1, Q6ZUT5, Q86XG3, Q96DC1, Q9BWK9	Gene names	DNAJC13, KIAA0678, RME8
Domain Architecture	No domain graphic available
Description	DnaJ homolog subfamily C member 13 (Required for receptor-mediated endocytosis 8).

PKCB1_HUMAN
θ value	0.0113563 (rank : 5)	NC score	0.079555 (rank : 6)
Query Neighborhood Hits	90	Target Neighborhood Hits	488	Shared Neighborhood Hits	16
SwissProt Accessions	Q9ULU4, Q13517, Q4JJ94, Q4JJ95, Q5TH09, Q6MZM1, Q8WXC5, Q9H1F3, Q9H1F4, Q9H1F5, Q9H1L8, Q9H1L9, Q9H2G5, Q9NYN3, Q9UIX6	Gene names	PRKCBP1, KIAA1125, RACK7, ZMYND8
Domain Architecture
Description	Protein kinase C-binding protein 1 (Rack7) (Cutaneous T-cell lymphoma- associated antigen se14-3) (CTCL tumor antigen se14-3) (Zinc finger MYND domain-containing protein 8).

RAF1_HUMAN
θ value	0.0113563 (rank : 6)	NC score	0.039157 (rank : 20)
Query Neighborhood Hits	90	Target Neighborhood Hits	886	Shared Neighborhood Hits	12
SwissProt Accessions	P04049	Gene names	RAF1, RAF
Domain Architecture
Description	RAF proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1) (Raf- 1) (C-RAF) (cRaf).

RAF1_MOUSE
θ value	0.0113563 (rank : 7)	NC score	0.039196 (rank : 19)
Query Neighborhood Hits	90	Target Neighborhood Hits	886	Shared Neighborhood Hits	13
SwissProt Accessions	Q99N57, Q91WH1	Gene names	Raf1, Craf
Domain Architecture
Description	RAF proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1) (Raf- 1) (C-RAF) (cRaf).

CD2L7_HUMAN
θ value	0.0431538 (rank : 8)	NC score	0.022671 (rank : 51)
Query Neighborhood Hits	90	Target Neighborhood Hits	1275	Shared Neighborhood Hits	32
SwissProt Accessions	Q9NYV4, O94978	Gene names	CRKRS, CRK7, KIAA0904
Domain Architecture
Description	Cell division cycle 2-related protein kinase 7 (EC 2.7.11.22) (CDC2- related protein kinase 7) (Cdc2-related kinase, arginine/serine-rich) (CrkRS).

LYST_HUMAN
θ value	0.0563607 (rank : 9)	NC score	0.074445 (rank : 7)
Query Neighborhood Hits	90	Target Neighborhood Hits	324	Shared Neighborhood Hits	8
SwissProt Accessions	Q99698, O43274, Q5T2U9, Q96TD7, Q96TD8, Q99709, Q9H133	Gene names	LYST, CHS, CHS1
Domain Architecture
Description	Lysosomal-trafficking regulator (Beige homolog).

ARAF_MOUSE
θ value	0.0736092 (rank : 10)	NC score	0.036554 (rank : 27)
Query Neighborhood Hits	90	Target Neighborhood Hits	874	Shared Neighborhood Hits	12
SwissProt Accessions	P04627, Q99J44, Q9CTT5, Q9D6R6, Q9DBU7	Gene names	Araf, A-raf, Araf1
Domain Architecture
Description	A-Raf proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1).

BRAF1_HUMAN
θ value	0.0961366 (rank : 11)	NC score	0.034021 (rank : 35)
Query Neighborhood Hits	90	Target Neighborhood Hits	883	Shared Neighborhood Hits	13
SwissProt Accessions	P15056, Q13878, Q9Y6T3	Gene names	BRAF, BRAF1, RAFB1
Domain Architecture
Description	B-Raf proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1) (p94) (v-Raf murine sarcoma viral oncogene homolog B1).

OFD1_HUMAN
θ value	0.0961366 (rank : 12)	NC score	0.036552 (rank : 28)
Query Neighborhood Hits	90	Target Neighborhood Hits	753	Shared Neighborhood Hits	14
SwissProt Accessions	O75665, O75666	Gene names	OFD1, CXorf5
Domain Architecture	No domain graphic available
Description	Oral-facial-digital syndrome 1 protein (Protein 71-7A).

NAB2_HUMAN
θ value	0.125558 (rank : 13)	NC score	0.101956 (rank : 4)
Query Neighborhood Hits	90	Target Neighborhood Hits	51	Shared Neighborhood Hits	6
SwissProt Accessions	Q15742, O76006, Q14797	Gene names	NAB2, MADER
Domain Architecture
Description	NGFI-A-binding protein 2 (EGR-1-binding protein 2) (Melanoma- associated delayed early response protein) (Protein MADER).

ARAF_HUMAN
θ value	0.279714 (rank : 14)	NC score	0.034392 (rank : 34)
Query Neighborhood Hits	90	Target Neighborhood Hits	924	Shared Neighborhood Hits	14
SwissProt Accessions	P10398, P07557, Q5H9B3	Gene names	ARAF, ARAF1, PKS, PKS2
Domain Architecture
Description	A-Raf proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1) (A- raf-1) (Proto-oncogene Pks).

CHD3_HUMAN
θ value	0.279714 (rank : 15)	NC score	0.037863 (rank : 23)
Query Neighborhood Hits	90	Target Neighborhood Hits	397	Shared Neighborhood Hits	14
SwissProt Accessions	Q12873, Q9Y4I0	Gene names	CHD3
Domain Architecture
Description	Chromodomain helicase-DNA-binding protein 3 (EC 3.6.1.-) (ATP- dependent helicase CHD3) (CHD-3) (Mi-2 autoantigen 240 kDa protein) (Mi2-alpha) (Zinc-finger helicase) (hZFH).

LYST_MOUSE
θ value	0.279714 (rank : 16)	NC score	0.068837 (rank : 8)
Query Neighborhood Hits	90	Target Neighborhood Hits	286	Shared Neighborhood Hits	9
SwissProt Accessions	P97412, Q62403, Q8VBS6	Gene names	Lyst, Bg, Chs1
Domain Architecture
Description	Lysosomal-trafficking regulator (Beige protein) (CHS1 homolog).

NFH_MOUSE
θ value	0.365318 (rank : 17)	NC score	0.027968 (rank : 43)
Query Neighborhood Hits	90	Target Neighborhood Hits	2247	Shared Neighborhood Hits	43
SwissProt Accessions	P19246, Q5SVF6, Q61959	Gene names	Nefh, Nfh
Domain Architecture
Description	Neurofilament triplet H protein (200 kDa neurofilament protein) (Neurofilament heavy polypeptide) (NF-H).

PHC3_HUMAN
θ value	0.365318 (rank : 18)	NC score	0.052333 (rank : 13)
Query Neighborhood Hits	90	Target Neighborhood Hits	218	Shared Neighborhood Hits	14
SwissProt Accessions	Q8NDX5, Q5HYF0, Q6NSG2, Q8NFT7, Q8NFZ1, Q8TBM2, Q9H971, Q9H9I4	Gene names	PHC3, EDR3, PH3
Domain Architecture	No domain graphic available
Description	Polyhomeotic-like protein 3 (hPH3) (Homolog of polyhomeotic 3) (Early development regulatory protein 3).

CNTRB_MOUSE
θ value	0.47712 (rank : 19)	NC score	0.022743 (rank : 50)
Query Neighborhood Hits	90	Target Neighborhood Hits	1029	Shared Neighborhood Hits	15
SwissProt Accessions	Q8CB62, Q5NCF3	Gene names	Cntrob, Lip8
Domain Architecture	No domain graphic available
Description	Centrobin (LYST-interacting protein 8).

HGS_MOUSE
θ value	0.47712 (rank : 20)	NC score	0.035134 (rank : 32)
Query Neighborhood Hits	90	Target Neighborhood Hits	589	Shared Neighborhood Hits	18
SwissProt Accessions	Q99LI8, Q61691, Q8BQW3	Gene names	Hgs, Hrs
Domain Architecture	No domain graphic available
Description	Hepatocyte growth factor-regulated tyrosine kinase substrate.

NAB2_MOUSE
θ value	0.47712 (rank : 21)	NC score	0.089029 (rank : 5)
Query Neighborhood Hits	90	Target Neighborhood Hits	69	Shared Neighborhood Hits	6
SwissProt Accessions	Q61127	Gene names	Nab2
Domain Architecture
Description	NGFI-A-binding protein 2 (EGR-1-binding protein 2).

EVI2B_MOUSE
θ value	0.813845 (rank : 22)	NC score	0.047828 (rank : 15)
Query Neighborhood Hits	90	Target Neighborhood Hits	87	Shared Neighborhood Hits	5
SwissProt Accessions	Q8VD58, Q3U1A3	Gene names	Evi2b
Domain Architecture	No domain graphic available
Description	EVI2B protein precursor (Ecotropic viral integration site 2B protein).

ICB1_MOUSE
θ value	0.813845 (rank : 23)	NC score	0.037608 (rank : 25)
Query Neighborhood Hits	90	Target Neighborhood Hits	69	Shared Neighborhood Hits	6
SwissProt Accessions	Q91YX0	Gene names	Icb1
Domain Architecture	No domain graphic available
Description	Induced by contact to basement membrane 1 protein homolog (ICB-1 protein).

NACAM_MOUSE
θ value	0.813845 (rank : 24)	NC score	0.034999 (rank : 33)
Query Neighborhood Hits	90	Target Neighborhood Hits	1866	Shared Neighborhood Hits	37
SwissProt Accessions	P70670	Gene names	Naca
Domain Architecture	No domain graphic available
Description	Nascent polypeptide-associated complex subunit alpha, muscle-specific form (Alpha-NAC, muscle-specific form).

ATM_HUMAN
θ value	1.06291 (rank : 25)	NC score	0.037723 (rank : 24)
Query Neighborhood Hits	90	Target Neighborhood Hits	78	Shared Neighborhood Hits	4
SwissProt Accessions	Q13315, O15429, Q12758, Q16551, Q93007, Q9NP02, Q9UCX7	Gene names	ATM
Domain Architecture
Description	Serine-protein kinase ATM (EC 2.7.11.1) (Ataxia telangiectasia mutated) (A-T, mutated).

DYHC_HUMAN
θ value	1.06291 (rank : 26)	NC score	0.035774 (rank : 31)
Query Neighborhood Hits	90	Target Neighborhood Hits	733	Shared Neighborhood Hits	13
SwissProt Accessions	Q14204, Q6DKQ7, Q8WU28, Q92814, Q9Y4G5	Gene names	DYNC1H1, DNCH1, DNECL, KIAA0325
Domain Architecture	No domain graphic available
Description	Dynein heavy chain, cytosolic (DYHC) (Cytoplasmic dynein heavy chain 1) (DHC1) (Dynein heavy chain 1, cytoplasmic 1).

DYHC_MOUSE
θ value	1.06291 (rank : 27)	NC score	0.035832 (rank : 30)
Query Neighborhood Hits	90	Target Neighborhood Hits	729	Shared Neighborhood Hits	13
SwissProt Accessions	Q9JHU4	Gene names	Dync1h1, Dnch1, Dnchc1
Domain Architecture
Description	Dynein heavy chain, cytosolic (DYHC) (Cytoplasmic dynein heavy chain 1) (DHC1) (Dynein heavy chain 1, cytoplasmic 1).

PI3R4_HUMAN
θ value	1.06291 (rank : 28)	NC score	0.038596 (rank : 21)
Query Neighborhood Hits	90	Target Neighborhood Hits	534	Shared Neighborhood Hits	10
SwissProt Accessions	Q99570	Gene names	PIK3R4
Domain Architecture	No domain graphic available
Description	Phosphoinositide 3-kinase regulatory subunit 4 (EC 2.7.11.1) (PI3- kinase regulatory subunit 4) (PI3-kinase p150 subunit) (Phosphoinositide 3-kinase adaptor protein).

RGS3_HUMAN
θ value	1.06291 (rank : 29)	NC score	0.022314 (rank : 52)
Query Neighborhood Hits	90	Target Neighborhood Hits	1375	Shared Neighborhood Hits	25
SwissProt Accessions	P49796, Q5VXC1, Q5VZ05, Q6ZRM5, Q8IUQ1, Q8NC47, Q8NFN4, Q8NFN5, Q8TD59, Q8TD68, Q8WXA0	Gene names	RGS3
Domain Architecture
Description	Regulator of G-protein signaling 3 (RGS3) (RGP3).

IWS1_HUMAN
θ value	1.38821 (rank : 30)	NC score	0.029093 (rank : 40)
Query Neighborhood Hits	90	Target Neighborhood Hits	1241	Shared Neighborhood Hits	27
SwissProt Accessions	Q96ST2, Q6P157, Q8N3E8, Q96MI7, Q9NV97, Q9NWH8	Gene names	IWS1, IWS1L
Domain Architecture	No domain graphic available
Description	IWS1 homolog (IWS1-like protein).

ORC3_MOUSE
θ value	1.38821 (rank : 31)	NC score	0.062276 (rank : 10)
Query Neighborhood Hits	90	Target Neighborhood Hits	37	Shared Neighborhood Hits	4
SwissProt Accessions	Q9JK30	Gene names	Orc3l, Orc3
Domain Architecture
Description	Origin recognition complex subunit 3 (Origin recognition complex subunit Latheo).

RABE1_HUMAN
θ value	1.38821 (rank : 32)	NC score	0.019229 (rank : 64)
Query Neighborhood Hits	90	Target Neighborhood Hits	1104	Shared Neighborhood Hits	14
SwissProt Accessions	Q15276, O95369, Q8IVX3	Gene names	RABEP1, RABPT5, RABPT5A
Domain Architecture
Description	Rab GTPase-binding effector protein 1 (Rabaptin-5) (Rabaptin-5alpha) (Rabaptin-4) (NY-REN-17 antigen).

SRRM2_MOUSE
θ value	1.38821 (rank : 33)	NC score	0.037104 (rank : 26)
Query Neighborhood Hits	90	Target Neighborhood Hits	1470	Shared Neighborhood Hits	30
SwissProt Accessions	Q8BTI8, Q3TBY5, Q569P9, Q80U37, Q8K383	Gene names	Srrm2, Kiaa0324
Domain Architecture	No domain graphic available
Description	Serine/arginine repetitive matrix protein 2.

CHD5_HUMAN
θ value	1.81305 (rank : 34)	NC score	0.028899 (rank : 41)
Query Neighborhood Hits	90	Target Neighborhood Hits	349	Shared Neighborhood Hits	13
SwissProt Accessions	Q8TDI0, O75032, Q5TG89, Q9UFR9	Gene names	CHD5
Domain Architecture	No domain graphic available
Description	Chromodomain helicase-DNA-binding protein 5 (EC 3.6.1.-) (ATP- dependent helicase CHD5) (CHD-5).

MAP9_MOUSE
θ value	1.81305 (rank : 35)	NC score	0.030136 (rank : 39)
Query Neighborhood Hits	90	Target Neighborhood Hits	529	Shared Neighborhood Hits	16
SwissProt Accessions	Q3TRR0, Q3UUD1, Q3UX85, Q3UXE7, Q5M8N8, Q6P8K1, Q8BMM4, Q8BYP7	Gene names	Map9, Asap
Domain Architecture	No domain graphic available
Description	Microtubule-associated protein 9 (Aster-associated protein).

PCIF1_HUMAN
θ value	1.81305 (rank : 36)	NC score	0.030488 (rank : 38)
Query Neighborhood Hits	90	Target Neighborhood Hits	92	Shared Neighborhood Hits	4
SwissProt Accessions	Q9H4Z3, Q9NT85	Gene names	PCIF1, C20orf67
Domain Architecture
Description	Phosphorylated CTD-interacting factor 1.

VAV3_HUMAN
θ value	1.81305 (rank : 37)	NC score	0.019578 (rank : 63)
Query Neighborhood Hits	90	Target Neighborhood Hits	398	Shared Neighborhood Hits	6
SwissProt Accessions	Q9UKW4, O95230, Q9Y5X8	Gene names	VAV3
Domain Architecture
Description	Protein vav-3.

VAV3_MOUSE
θ value	1.81305 (rank : 38)	NC score	0.020431 (rank : 60)
Query Neighborhood Hits	90	Target Neighborhood Hits	404	Shared Neighborhood Hits	8
SwissProt Accessions	Q9R0C8, Q7TS85	Gene names	Vav3
Domain Architecture
Description	Protein vav-3.

DCR1A_MOUSE
θ value	2.36792 (rank : 39)	NC score	0.039668 (rank : 17)
Query Neighborhood Hits	90	Target Neighborhood Hits	59	Shared Neighborhood Hits	3
SwissProt Accessions	Q9JIC3, Q571H5, Q6GQR6	Gene names	Dclre1a, Kiaa0086, Snm1, Snm1a
Domain Architecture	No domain graphic available
Description	DNA cross-link repair 1A protein.

FBW1B_HUMAN
θ value	2.36792 (rank : 40)	NC score	0.018405 (rank : 66)
Query Neighborhood Hits	90	Target Neighborhood Hits	327	Shared Neighborhood Hits	7
SwissProt Accessions	Q9UKB1, Q9P2S8, Q9P2S9, Q9Y4C6	Gene names	FBXW11, BTRCP2, FBW1B, FBXW1B, KIAA0696
Domain Architecture
Description	F-box/WD repeat protein 11 (F-box/WD repeat protein 1B) (F-box and WD repeats protein beta-TrCP2).

ATX2L_MOUSE
θ value	3.0926 (rank : 41)	NC score	0.027815 (rank : 44)
Query Neighborhood Hits	90	Target Neighborhood Hits	401	Shared Neighborhood Hits	15
SwissProt Accessions	Q7TQH0, Q80XN9, Q8K059	Gene names	Atxn2l, A2lp
Domain Architecture	No domain graphic available
Description	Ataxin-2-like protein.

ERR1_HUMAN
θ value	3.0926 (rank : 42)	NC score	0.008298 (rank : 86)
Query Neighborhood Hits	90	Target Neighborhood Hits	157	Shared Neighborhood Hits	5
SwissProt Accessions	P11474, Q14514	Gene names	ESRRA, ERR1, ESRL1, NR3B1
Domain Architecture
Description	Steroid hormone receptor ERR1 (Estrogen-related receptor, alpha) (ERR- alpha) (Estrogen receptor-like 1).

IF4B_MOUSE
θ value	3.0926 (rank : 43)	NC score	0.033290 (rank : 37)
Query Neighborhood Hits	90	Target Neighborhood Hits	368	Shared Neighborhood Hits	13
SwissProt Accessions	Q8BGD9, Q3TD64	Gene names	Eif4b
Domain Architecture	No domain graphic available
Description	Eukaryotic translation initiation factor 4B (eIF-4B).

MDC1_HUMAN
θ value	3.0926 (rank : 44)	NC score	0.028025 (rank : 42)
Query Neighborhood Hits	90	Target Neighborhood Hits	1446	Shared Neighborhood Hits	31
SwissProt Accessions	Q14676, Q5JP55, Q5JP56, Q5ST83, Q68CQ3, Q86Z06, Q96QC2	Gene names	MDC1, KIAA0170, NFBD1
Domain Architecture	No domain graphic available
Description	Mediator of DNA damage checkpoint protein 1 (Nuclear factor with BRCT domains 1).

SACS_MOUSE
θ value	3.0926 (rank : 45)	NC score	0.041878 (rank : 16)
Query Neighborhood Hits	90	Target Neighborhood Hits	99	Shared Neighborhood Hits	5
SwissProt Accessions	Q9JLC8	Gene names	Sacs
Domain Architecture
Description	Sacsin.

ORC3_HUMAN
θ value	4.03905 (rank : 46)	NC score	0.049941 (rank : 14)
Query Neighborhood Hits	90	Target Neighborhood Hits	39	Shared Neighborhood Hits	4
SwissProt Accessions	Q9UBD5, Q13565, Q6IUY7, Q9UG44, Q9UNT6	Gene names	ORC3L, LATHEO
Domain Architecture
Description	Origin recognition complex subunit 3 (Origin recognition complex subunit Latheo).

STX18_HUMAN
θ value	4.03905 (rank : 47)	NC score	0.036530 (rank : 29)
Query Neighborhood Hits	90	Target Neighborhood Hits	225	Shared Neighborhood Hits	8
SwissProt Accessions	Q9P2W9, Q596L3, Q5TZP5	Gene names	STX18, GIG9
Domain Architecture	No domain graphic available
Description	Syntaxin-18 (Growth-inhibiting gene 9 protein).

AFF2_HUMAN
θ value	5.27518 (rank : 48)	NC score	0.021402 (rank : 53)
Query Neighborhood Hits	90	Target Neighborhood Hits	218	Shared Neighborhood Hits	14
SwissProt Accessions	P51816, O43786, O60215, P78407, Q13521, Q14323, Q9UNA5	Gene names	AFF2, FMR2, OX19
Domain Architecture
Description	AF4/FMR2 family member 2 (Fragile X mental retardation 2 protein) (Protein FMR-2) (FMR2P) (Protein Ox19) (Fragile X E mental retardation syndrome protein).

ANR33_MOUSE
θ value	5.27518 (rank : 49)	NC score	0.019150 (rank : 65)
Query Neighborhood Hits	90	Target Neighborhood Hits	225	Shared Neighborhood Hits	4
SwissProt Accessions	Q8BXP5, Q8BXP4, Q8R1Z1	Gene names	Ankrd33
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 33.

CA103_MOUSE
θ value	5.27518 (rank : 50)	NC score	0.021037 (rank : 54)
Query Neighborhood Hits	90	Target Neighborhood Hits	37	Shared Neighborhood Hits	3
SwissProt Accessions	Q8CDD9, Q8C893	Gene names
Domain Architecture	No domain graphic available
Description	Protein C1orf103 homolog.

CCD21_MOUSE
θ value	5.27518 (rank : 51)	NC score	0.020805 (rank : 57)
Query Neighborhood Hits	90	Target Neighborhood Hits	1135	Shared Neighborhood Hits	17
SwissProt Accessions	Q8BMK0, Q8BUF1, Q8K0E6	Gene names	Ccdc21
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 21.

CGRE1_HUMAN
θ value	5.27518 (rank : 52)	NC score	0.027008 (rank : 46)
Query Neighborhood Hits	90	Target Neighborhood Hits	354	Shared Neighborhood Hits	8
SwissProt Accessions	Q99674	Gene names	CGREF1, CGR11
Domain Architecture	No domain graphic available
Description	Cell growth regulator with EF hand domain 1 (Cell growth regulatory gene 11 protein).

CHD8_HUMAN
θ value	5.27518 (rank : 53)	NC score	0.020274 (rank : 61)
Query Neighborhood Hits	90	Target Neighborhood Hits	235	Shared Neighborhood Hits	10
SwissProt Accessions	Q9HCK8, Q68DQ0, Q8N3Z9, Q8NCY4, Q8TBR9, Q96F26	Gene names	CHD8, HELSNF1, KIAA1564
Domain Architecture	No domain graphic available
Description	Chromodomain-helicase-DNA-binding protein 8 (EC 3.6.1.-) (ATP- dependent helicase CHD8) (CHD-8) (Helicase with SNF2 domain 1).

CN155_HUMAN
θ value	5.27518 (rank : 54)	NC score	0.067688 (rank : 9)
Query Neighborhood Hits	90	Target Neighborhood Hits	385	Shared Neighborhood Hits	23
SwissProt Accessions	Q5H9T9, Q5H9U7, Q86YI2, Q9H0J3	Gene names	C14orf155
Domain Architecture	No domain graphic available
Description	Protein C14orf155.

IF4B_HUMAN
θ value	5.27518 (rank : 55)	NC score	0.026950 (rank : 47)
Query Neighborhood Hits	90	Target Neighborhood Hits	417	Shared Neighborhood Hits	10
SwissProt Accessions	P23588	Gene names	EIF4B
Domain Architecture
Description	Eukaryotic translation initiation factor 4B (eIF-4B).

PIAS1_HUMAN
θ value	5.27518 (rank : 56)	NC score	0.020494 (rank : 59)
Query Neighborhood Hits	90	Target Neighborhood Hits	36	Shared Neighborhood Hits	4
SwissProt Accessions	O75925, Q99751, Q9UN02	Gene names	PIAS1, DDXBP1
Domain Architecture
Description	Protein inhibitor of activated STAT protein 1 (Gu-binding protein) (GBP) (RNA helicase II-binding protein) (DEAD/H box-binding protein 1).

RBM16_HUMAN
θ value	5.27518 (rank : 57)	NC score	0.033506 (rank : 36)
Query Neighborhood Hits	90	Target Neighborhood Hits	300	Shared Neighborhood Hits	11
SwissProt Accessions	Q9UPN6, Q5TBU6, Q9BQN8, Q9BX43	Gene names	RBM16, KIAA1116
Domain Architecture
Description	Putative RNA-binding protein 16 (RNA-binding motif protein 16).

SACS_HUMAN
θ value	5.27518 (rank : 58)	NC score	0.037879 (rank : 22)
Query Neighborhood Hits	90	Target Neighborhood Hits	128	Shared Neighborhood Hits	6
SwissProt Accessions	Q9NZJ4, O94835	Gene names	SACS, KIAA0730
Domain Architecture
Description	Sacsin.

TSH2_MOUSE
θ value	5.27518 (rank : 59)	NC score	0.010299 (rank : 83)
Query Neighborhood Hits	90	Target Neighborhood Hits	467	Shared Neighborhood Hits	3
SwissProt Accessions	Q68FE9, Q5DTF1, Q6AXH5, Q9JL71	Gene names	Tshz2, Kiaa4248, Sdccag33l, Tsh2, Zfp218, Znf218
Domain Architecture	No domain graphic available
Description	Teashirt homolog 2 (Zinc finger protein 218) (SDCCAG33-like protein).

XKR7_MOUSE
θ value	5.27518 (rank : 60)	NC score	0.013298 (rank : 74)
Query Neighborhood Hits	90	Target Neighborhood Hits	146	Shared Neighborhood Hits	4
SwissProt Accessions	Q5GH64	Gene names	Xkr7, Xrg7
Domain Architecture	No domain graphic available
Description	XK-related protein 7.

ZSCA1_HUMAN
θ value	5.27518 (rank : 61)	NC score	0.001432 (rank : 91)
Query Neighborhood Hits	90	Target Neighborhood Hits	724	Shared Neighborhood Hits	3
SwissProt Accessions	Q8NBB4, Q6WLH8, Q86WS8	Gene names	ZSCAN1
Domain Architecture	No domain graphic available
Description	Zinc finger and SCAN domain-containing protein 1.

ANK2_HUMAN
θ value	6.88961 (rank : 62)	NC score	0.012669 (rank : 76)
Query Neighborhood Hits	90	Target Neighborhood Hits	1615	Shared Neighborhood Hits	32
SwissProt Accessions	Q01484, Q01485	Gene names	ANK2
Domain Architecture
Description	Ankyrin-2 (Brain ankyrin) (Ankyrin-B) (Ankyrin, nonerythroid).

ATX2_HUMAN
θ value	6.88961 (rank : 63)	NC score	0.027150 (rank : 45)
Query Neighborhood Hits	90	Target Neighborhood Hits	375	Shared Neighborhood Hits	19
SwissProt Accessions	Q99700, Q6ZQZ7, Q99493	Gene names	ATXN2, ATX2, SCA2, TNRC13
Domain Architecture	No domain graphic available
Description	Ataxin-2 (Spinocerebellar ataxia type 2 protein) (Trinucleotide repeat-containing gene 13 protein).

CAND2_MOUSE
θ value	6.88961 (rank : 64)	NC score	0.017019 (rank : 68)
Query Neighborhood Hits	90	Target Neighborhood Hits	44	Shared Neighborhood Hits	3
SwissProt Accessions	Q6ZQ73, Q6PHT7	Gene names	Cand2, Kiaa0667, Tip120b
Domain Architecture	No domain graphic available
Description	Cullin-associated NEDD8-dissociated protein 2 (Cullin-associated and neddylation-dissociated protein 2) (p120 CAND2) (TBP-interacting protein TIP120B) (TBP-interacting protein of 120 kDa B).

EXOSX_HUMAN
θ value	6.88961 (rank : 65)	NC score	0.015868 (rank : 71)
Query Neighborhood Hits	90	Target Neighborhood Hits	30	Shared Neighborhood Hits	2
SwissProt Accessions	Q01780, Q15158	Gene names	EXOSC10, PMSCL, PMSCL2
Domain Architecture
Description	Exosome component 10 (Polymyositis/scleroderma autoantigen 2) (Autoantigen PM/Scl 2) (Polymyositis/scleroderma autoantigen 100 kDa) (PM/Scl-100) (P100 polymyositis-scleroderma overlap syndrome- associated autoantigen).

FBW1A_HUMAN
θ value	6.88961 (rank : 66)	NC score	0.013615 (rank : 73)
Query Neighborhood Hits	90	Target Neighborhood Hits	329	Shared Neighborhood Hits	7
SwissProt Accessions	Q9Y297, Q9Y213	Gene names	BTRC, BTRCP, FBW1A, FBXW1A
Domain Architecture
Description	F-box/WD repeat protein 1A (F-box and WD repeats protein beta-TrCP) (E3RSIkappaB) (pIkappaBalpha-E3 receptor subunit).

GAK4_HUMAN
θ value	6.88961 (rank : 67)	NC score	0.007291 (rank : 88)
Query Neighborhood Hits	90	Target Neighborhood Hits	415	Shared Neighborhood Hits	10
SwissProt Accessions	P63126, Q9UKH4	Gene names
Domain Architecture	No domain graphic available
Description	HERV-K_6q14.1 provirus ancestral Gag polyprotein (Gag polyprotein) (HERV-K109 Gag protein) (HERV-K(C6) Gag protein) [Contains: Matrix protein; Capsid protein; Nucleocapsid protein].

KI67_HUMAN
θ value	6.88961 (rank : 68)	NC score	0.039231 (rank : 18)
Query Neighborhood Hits	90	Target Neighborhood Hits	581	Shared Neighborhood Hits	16
SwissProt Accessions	P46013	Gene names	MKI67
Domain Architecture
Description	Antigen KI-67.

LAMB1_MOUSE
θ value	6.88961 (rank : 69)	NC score	0.004338 (rank : 90)
Query Neighborhood Hits	90	Target Neighborhood Hits	919	Shared Neighborhood Hits	10
SwissProt Accessions	P02469	Gene names	Lamb1-1, Lamb-1
Domain Architecture
Description	Laminin beta-1 chain precursor (Laminin B1 chain).

MAST4_HUMAN
θ value	6.88961 (rank : 70)	NC score	0.009514 (rank : 84)
Query Neighborhood Hits	90	Target Neighborhood Hits	1804	Shared Neighborhood Hits	33
SwissProt Accessions	O15021, Q6ZN07, Q96LY3	Gene names	MAST4, KIAA0303
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase 4 (EC 2.7.11.1).

PANK2_HUMAN
θ value	6.88961 (rank : 71)	NC score	0.011232 (rank : 79)
Query Neighborhood Hits	90	Target Neighborhood Hits	21	Shared Neighborhood Hits	2
SwissProt Accessions	Q9BZ23, Q5T7I2, Q8N7Q4, Q8TCR5, Q9BYW5, Q9HAF2	Gene names	PANK2, C20orf48
Domain Architecture
Description	Pantothenate kinase 2, mitochondrial precursor (EC 2.7.1.33) (Pantothenic acid kinase 2) (hPANK2).

PCLO_HUMAN
θ value	6.88961 (rank : 72)	NC score	0.020989 (rank : 55)
Query Neighborhood Hits	90	Target Neighborhood Hits	2046	Shared Neighborhood Hits	39
SwissProt Accessions	Q9Y6V0, O43373, O60305, Q9BVC8, Q9UIV2, Q9Y6U9	Gene names	PCLO, ACZ, KIAA0559
Domain Architecture
Description	Protein piccolo (Aczonin).

SON_HUMAN
θ value	6.88961 (rank : 73)	NC score	0.022939 (rank : 49)
Query Neighborhood Hits	90	Target Neighborhood Hits	1568	Shared Neighborhood Hits	23
SwissProt Accessions	P18583, O14487, O95981, Q14120, Q9H7B1, Q9P070, Q9P072, Q9UKP9, Q9UPY0	Gene names	SON, C21orf50, DBP5, KIAA1019, NREBP
Domain Architecture
Description	SON protein (SON3) (Negative regulatory element-binding protein) (NRE- binding protein) (DBP-5) (Bax antagonist selected in saccharomyces 1) (BASS1).

SVIL_HUMAN
θ value	6.88961 (rank : 74)	NC score	0.020696 (rank : 58)
Query Neighborhood Hits	90	Target Neighborhood Hits	232	Shared Neighborhood Hits	10
SwissProt Accessions	O95425, O60611, O60612, Q5VZK5, Q5VZK6, Q9H1R7	Gene names	SVIL
Domain Architecture	No domain graphic available
Description	Supervillin (Archvillin) (p205/p250).

AP3B1_MOUSE
θ value	8.99809 (rank : 75)	NC score	0.012960 (rank : 75)
Query Neighborhood Hits	90	Target Neighborhood Hits	302	Shared Neighborhood Hits	8
SwissProt Accessions	Q9Z1T1, Q91YR4	Gene names	Ap3b1
Domain Architecture
Description	AP-3 complex subunit beta-1 (Adapter-related protein complex 3 beta-1 subunit) (Beta3A-adaptin) (Adaptor protein complex AP-3 beta-1 subunit) (Clathrin assembly protein complex 3 beta-1 large chain).

BICD1_MOUSE
θ value	8.99809 (rank : 76)	NC score	0.007655 (rank : 87)
Query Neighborhood Hits	90	Target Neighborhood Hits	837	Shared Neighborhood Hits	13
SwissProt Accessions	Q8BR07, O55206, Q8BQ18, Q8BRR8, Q8C4D3, Q8CAK6, Q8R2J4, Q8R2J5, Q8R2J6, Q91YP7	Gene names	Bicd1
Domain Architecture	No domain graphic available
Description	Cytoskeleton-like bicaudal D protein homolog 1.

CH1B1_MOUSE
θ value	8.99809 (rank : 77)	NC score	0.011336 (rank : 78)
Query Neighborhood Hits	90	Target Neighborhood Hits	19	Shared Neighborhood Hits	2
SwissProt Accessions	Q99LU0, Q3UB77, Q9CXR5	Gene names	Chmp1b1, Chmp1b
Domain Architecture	No domain graphic available
Description	Charged multivesicular body protein 1b-1 (Chromatin-modifying protein 1b-1) (CHMP1b-1).

GGA2_HUMAN
θ value	8.99809 (rank : 78)	NC score	0.011719 (rank : 77)
Query Neighborhood Hits	90	Target Neighborhood Hits	114	Shared Neighborhood Hits	7
SwissProt Accessions	Q9UJY4, O14564, Q9NYN2, Q9UPS2	Gene names	GGA2, KIAA1080
Domain Architecture
Description	ADP-ribosylation factor-binding protein GGA2 (Golgi-localized, gamma ear-containing, ARF-binding protein 2) (Gamma-adaptin-related protein 2) (VHS domain and ear domain of gamma-adaptin) (Vear).

LRRK1_MOUSE
θ value	8.99809 (rank : 79)	NC score	0.010367 (rank : 82)
Query Neighborhood Hits	90	Target Neighborhood Hits	1267	Shared Neighborhood Hits	11
SwissProt Accessions	Q3UHC2, Q3U476, Q66JQ4, Q6GQR9, Q6NZF5, Q6ZPI4, Q8BKP3, Q8BU93, Q8BUY0, Q8BVV2, Q8R085	Gene names	Lrrk1, Kiaa1790
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat serine/threonine-protein kinase 1 (EC 2.7.11.1).

MBB1A_MOUSE
θ value	8.99809 (rank : 80)	NC score	0.026880 (rank : 48)
Query Neighborhood Hits	90	Target Neighborhood Hits	233	Shared Neighborhood Hits	15
SwissProt Accessions	Q7TPV4, O35851, Q80Y66, Q8R4X2, Q99KP0	Gene names	Mybbp1a, P160
Domain Architecture	No domain graphic available
Description	Myb-binding protein 1A (Myb-binding protein of 160 kDa).

MNDA_HUMAN
θ value	8.99809 (rank : 81)	NC score	0.011087 (rank : 80)
Query Neighborhood Hits	90	Target Neighborhood Hits	76	Shared Neighborhood Hits	8
SwissProt Accessions	P41218	Gene names	MNDA
Domain Architecture
Description	Myeloid cell nuclear differentiation antigen.

MYH14_MOUSE
θ value	8.99809 (rank : 82)	NC score	0.005078 (rank : 89)
Query Neighborhood Hits	90	Target Neighborhood Hits	1225	Shared Neighborhood Hits	15
SwissProt Accessions	Q6URW6, Q80V64, Q80ZE6	Gene names	Myh14
Domain Architecture	No domain graphic available
Description	Myosin-14 (Myosin heavy chain, nonmuscle IIc) (Nonmuscle myosin heavy chain IIc) (NMHC II-C).

NOL1_HUMAN
θ value	8.99809 (rank : 83)	NC score	0.019838 (rank : 62)
Query Neighborhood Hits	90	Target Neighborhood Hits	74	Shared Neighborhood Hits	8
SwissProt Accessions	P46087	Gene names	NOL1
Domain Architecture
Description	Proliferating-cell nucleolar antigen p120 (Proliferation-associated nucleolar protein p120).

PI5PA_HUMAN
θ value	8.99809 (rank : 84)	NC score	0.018287 (rank : 67)
Query Neighborhood Hits	90	Target Neighborhood Hits	749	Shared Neighborhood Hits	17
SwissProt Accessions	Q15735, Q32M61, Q6ZTH6, Q8N902, Q9UDT9	Gene names	PIB5PA, PIPP
Domain Architecture
Description	Phosphatidylinositol 4,5-bisphosphate 5-phosphatase A (EC 3.1.3.56).

PIAS1_MOUSE
θ value	8.99809 (rank : 85)	NC score	0.016701 (rank : 70)
Query Neighborhood Hits	90	Target Neighborhood Hits	32	Shared Neighborhood Hits	4
SwissProt Accessions	O88907, Q8C6H5	Gene names	Pias1, Ddxbp1
Domain Architecture
Description	Protein inhibitor of activated STAT protein 1 (DEAD/H box-binding protein 1).

PRRT3_HUMAN
θ value	8.99809 (rank : 86)	NC score	0.016859 (rank : 69)
Query Neighborhood Hits	90	Target Neighborhood Hits	998	Shared Neighborhood Hits	18
SwissProt Accessions	Q5FWE3, Q49AD0, Q6UXY6, Q8NBC9	Gene names	PRRT3, UNQ5823/PRO19642
Domain Architecture	No domain graphic available
Description	Proline-rich transmembrane protein 3.

RAVR1_MOUSE
θ value	8.99809 (rank : 87)	NC score	0.010456 (rank : 81)
Query Neighborhood Hits	90	Target Neighborhood Hits	179	Shared Neighborhood Hits	6
SwissProt Accessions	Q9CW46, Q5DTT6, Q811K0, Q8C3Z1, Q8CA14	Gene names	Raver1, Kiaa1978
Domain Architecture	No domain graphic available
Description	Ribonucleoprotein PTB-binding 1 (Protein raver-1).

RFIP4_HUMAN
θ value	8.99809 (rank : 88)	NC score	0.008483 (rank : 85)
Query Neighborhood Hits	90	Target Neighborhood Hits	785	Shared Neighborhood Hits	11
SwissProt Accessions	Q86YS3, Q8N829, Q8NDT7, Q969D8	Gene names	RAB11FIP4, KIAA1821
Domain Architecture	No domain graphic available
Description	Rab11 family-interacting protein 4 (Rab11-FIP4).

RP1_MOUSE
θ value	8.99809 (rank : 89)	NC score	0.014801 (rank : 72)
Query Neighborhood Hits	90	Target Neighborhood Hits	104	Shared Neighborhood Hits	3
SwissProt Accessions	P56716	Gene names	Rp1, Orp1, Rp1h
Domain Architecture
Description	Oxygen-regulated protein 1 (Retinitis pigmentosa RP1 protein homolog).

UBF1_HUMAN
θ value	8.99809 (rank : 90)	NC score	0.020843 (rank : 56)
Query Neighborhood Hits	90	Target Neighborhood Hits	415	Shared Neighborhood Hits	9
SwissProt Accessions	P17480	Gene names	UBTF, UBF, UBF1
Domain Architecture
Description	Nucleolar transcription factor 1 (Upstream-binding factor 1) (UBF-1) (Autoantigen NOR-90).

IF39_HUMAN
θ value	θ > 10 (rank : 91)	NC score	0.055904 (rank : 12)
Query Neighborhood Hits	90	Target Neighborhood Hits	187	Shared Neighborhood Hits	13
SwissProt Accessions	P55884, Q9UMF9	Gene names	EIF3S9
Domain Architecture
Description	Eukaryotic translation initiation factor 3 subunit 9 (eIF-3 eta) (eIF3 p116) (eIF3 p110) (eIF3b) (Prt1 homolog) (hPrt1).

Hits sorted by NC score

SYMPK_HUMAN
NC score	0.999962 (rank : 1)	θ value	0 (rank : 1)
Query Neighborhood Hits	90	Target Neighborhood Hits	90	Shared Neighborhood Hits	90
SwissProt Accessions	Q92797, O00521, O00689, O00733, Q59GT5, Q8N2U5	Gene names	SYMPK, SPK
Domain Architecture	No domain graphic available
Description	Symplekin.

SYMPK_MOUSE
NC score	0.978265 (rank : 2)	θ value	0 (rank : 2)
Query Neighborhood Hits	90	Target Neighborhood Hits	109	Shared Neighborhood Hits	49
SwissProt Accessions	Q80X82	Gene names	Sympk
Domain Architecture	No domain graphic available
Description	Symplekin.

DNJCD_HUMAN
NC score	0.119356 (rank : 3)	θ value	0.0113563 (rank : 4)
Query Neighborhood Hits	90	Target Neighborhood Hits	87	Shared Neighborhood Hits	5
SwissProt Accessions	O75165, Q6PI82, Q6UJ77, Q6ZSW1, Q6ZUT5, Q86XG3, Q96DC1, Q9BWK9	Gene names	DNAJC13, KIAA0678, RME8
Domain Architecture	No domain graphic available
Description	DnaJ homolog subfamily C member 13 (Required for receptor-mediated endocytosis 8).

NAB2_HUMAN
NC score	0.101956 (rank : 4)	θ value	0.125558 (rank : 13)
Query Neighborhood Hits	90	Target Neighborhood Hits	51	Shared Neighborhood Hits	6
SwissProt Accessions	Q15742, O76006, Q14797	Gene names	NAB2, MADER
Domain Architecture
Description	NGFI-A-binding protein 2 (EGR-1-binding protein 2) (Melanoma- associated delayed early response protein) (Protein MADER).

NAB2_MOUSE
NC score	0.089029 (rank : 5)	θ value	0.47712 (rank : 21)
Query Neighborhood Hits	90	Target Neighborhood Hits	69	Shared Neighborhood Hits	6
SwissProt Accessions	Q61127	Gene names	Nab2
Domain Architecture
Description	NGFI-A-binding protein 2 (EGR-1-binding protein 2).

PKCB1_HUMAN
NC score	0.079555 (rank : 6)	θ value	0.0113563 (rank : 5)
Query Neighborhood Hits	90	Target Neighborhood Hits	488	Shared Neighborhood Hits	16
SwissProt Accessions	Q9ULU4, Q13517, Q4JJ94, Q4JJ95, Q5TH09, Q6MZM1, Q8WXC5, Q9H1F3, Q9H1F4, Q9H1F5, Q9H1L8, Q9H1L9, Q9H2G5, Q9NYN3, Q9UIX6	Gene names	PRKCBP1, KIAA1125, RACK7, ZMYND8
Domain Architecture
Description	Protein kinase C-binding protein 1 (Rack7) (Cutaneous T-cell lymphoma- associated antigen se14-3) (CTCL tumor antigen se14-3) (Zinc finger MYND domain-containing protein 8).

LYST_HUMAN
NC score	0.074445 (rank : 7)	θ value	0.0563607 (rank : 9)
Query Neighborhood Hits	90	Target Neighborhood Hits	324	Shared Neighborhood Hits	8
SwissProt Accessions	Q99698, O43274, Q5T2U9, Q96TD7, Q96TD8, Q99709, Q9H133	Gene names	LYST, CHS, CHS1
Domain Architecture
Description	Lysosomal-trafficking regulator (Beige homolog).

LYST_MOUSE
NC score	0.068837 (rank : 8)	θ value	0.279714 (rank : 16)
Query Neighborhood Hits	90	Target Neighborhood Hits	286	Shared Neighborhood Hits	9
SwissProt Accessions	P97412, Q62403, Q8VBS6	Gene names	Lyst, Bg, Chs1
Domain Architecture
Description	Lysosomal-trafficking regulator (Beige protein) (CHS1 homolog).

CN155_HUMAN
NC score	0.067688 (rank : 9)	θ value	5.27518 (rank : 54)
Query Neighborhood Hits	90	Target Neighborhood Hits	385	Shared Neighborhood Hits	23
SwissProt Accessions	Q5H9T9, Q5H9U7, Q86YI2, Q9H0J3	Gene names	C14orf155
Domain Architecture	No domain graphic available
Description	Protein C14orf155.

ORC3_MOUSE
NC score	0.062276 (rank : 10)	θ value	1.38821 (rank : 31)
Query Neighborhood Hits	90	Target Neighborhood Hits	37	Shared Neighborhood Hits	4
SwissProt Accessions	Q9JK30	Gene names	Orc3l, Orc3
Domain Architecture
Description	Origin recognition complex subunit 3 (Origin recognition complex subunit Latheo).

OGFR_HUMAN
NC score	0.058798 (rank : 11)	θ value	0.000461057 (rank : 3)
Query Neighborhood Hits	90	Target Neighborhood Hits	1582	Shared Neighborhood Hits	28
SwissProt Accessions	Q9NZT2, O96029, Q4VXW5, Q96CM2, Q9BQW1, Q9H4H0, Q9H7J5, Q9NZT3, Q9NZT4	Gene names	OGFR
Domain Architecture
Description	Opioid growth factor receptor (OGFr) (Zeta-type opioid receptor) (7-60 protein).

IF39_HUMAN
NC score	0.055904 (rank : 12)	θ value	θ > 10 (rank : 91)
Query Neighborhood Hits	90	Target Neighborhood Hits	187	Shared Neighborhood Hits	13
SwissProt Accessions	P55884, Q9UMF9	Gene names	EIF3S9
Domain Architecture
Description	Eukaryotic translation initiation factor 3 subunit 9 (eIF-3 eta) (eIF3 p116) (eIF3 p110) (eIF3b) (Prt1 homolog) (hPrt1).

PHC3_HUMAN
NC score	0.052333 (rank : 13)	θ value	0.365318 (rank : 18)
Query Neighborhood Hits	90	Target Neighborhood Hits	218	Shared Neighborhood Hits	14
SwissProt Accessions	Q8NDX5, Q5HYF0, Q6NSG2, Q8NFT7, Q8NFZ1, Q8TBM2, Q9H971, Q9H9I4	Gene names	PHC3, EDR3, PH3
Domain Architecture	No domain graphic available
Description	Polyhomeotic-like protein 3 (hPH3) (Homolog of polyhomeotic 3) (Early development regulatory protein 3).

ORC3_HUMAN
NC score	0.049941 (rank : 14)	θ value	4.03905 (rank : 46)
Query Neighborhood Hits	90	Target Neighborhood Hits	39	Shared Neighborhood Hits	4
SwissProt Accessions	Q9UBD5, Q13565, Q6IUY7, Q9UG44, Q9UNT6	Gene names	ORC3L, LATHEO
Domain Architecture
Description	Origin recognition complex subunit 3 (Origin recognition complex subunit Latheo).

EVI2B_MOUSE
NC score	0.047828 (rank : 15)	θ value	0.813845 (rank : 22)
Query Neighborhood Hits	90	Target Neighborhood Hits	87	Shared Neighborhood Hits	5
SwissProt Accessions	Q8VD58, Q3U1A3	Gene names	Evi2b
Domain Architecture	No domain graphic available
Description	EVI2B protein precursor (Ecotropic viral integration site 2B protein).

SACS_MOUSE
NC score	0.041878 (rank : 16)	θ value	3.0926 (rank : 45)
Query Neighborhood Hits	90	Target Neighborhood Hits	99	Shared Neighborhood Hits	5
SwissProt Accessions	Q9JLC8	Gene names	Sacs
Domain Architecture
Description	Sacsin.

DCR1A_MOUSE
NC score	0.039668 (rank : 17)	θ value	2.36792 (rank : 39)
Query Neighborhood Hits	90	Target Neighborhood Hits	59	Shared Neighborhood Hits	3
SwissProt Accessions	Q9JIC3, Q571H5, Q6GQR6	Gene names	Dclre1a, Kiaa0086, Snm1, Snm1a
Domain Architecture	No domain graphic available
Description	DNA cross-link repair 1A protein.

KI67_HUMAN
NC score	0.039231 (rank : 18)	θ value	6.88961 (rank : 68)
Query Neighborhood Hits	90	Target Neighborhood Hits	581	Shared Neighborhood Hits	16
SwissProt Accessions	P46013	Gene names	MKI67
Domain Architecture
Description	Antigen KI-67.

RAF1_MOUSE
NC score	0.039196 (rank : 19)	θ value	0.0113563 (rank : 7)
Query Neighborhood Hits	90	Target Neighborhood Hits	886	Shared Neighborhood Hits	13
SwissProt Accessions	Q99N57, Q91WH1	Gene names	Raf1, Craf
Domain Architecture
Description	RAF proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1) (Raf- 1) (C-RAF) (cRaf).

RAF1_HUMAN
NC score	0.039157 (rank : 20)	θ value	0.0113563 (rank : 6)
Query Neighborhood Hits	90	Target Neighborhood Hits	886	Shared Neighborhood Hits	12
SwissProt Accessions	P04049	Gene names	RAF1, RAF
Domain Architecture
Description	RAF proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1) (Raf- 1) (C-RAF) (cRaf).

PI3R4_HUMAN
NC score	0.038596 (rank : 21)	θ value	1.06291 (rank : 28)
Query Neighborhood Hits	90	Target Neighborhood Hits	534	Shared Neighborhood Hits	10
SwissProt Accessions	Q99570	Gene names	PIK3R4
Domain Architecture	No domain graphic available
Description	Phosphoinositide 3-kinase regulatory subunit 4 (EC 2.7.11.1) (PI3- kinase regulatory subunit 4) (PI3-kinase p150 subunit) (Phosphoinositide 3-kinase adaptor protein).

SACS_HUMAN
NC score	0.037879 (rank : 22)	θ value	5.27518 (rank : 58)
Query Neighborhood Hits	90	Target Neighborhood Hits	128	Shared Neighborhood Hits	6
SwissProt Accessions	Q9NZJ4, O94835	Gene names	SACS, KIAA0730
Domain Architecture
Description	Sacsin.

CHD3_HUMAN
NC score	0.037863 (rank : 23)	θ value	0.279714 (rank : 15)
Query Neighborhood Hits	90	Target Neighborhood Hits	397	Shared Neighborhood Hits	14
SwissProt Accessions	Q12873, Q9Y4I0	Gene names	CHD3
Domain Architecture
Description	Chromodomain helicase-DNA-binding protein 3 (EC 3.6.1.-) (ATP- dependent helicase CHD3) (CHD-3) (Mi-2 autoantigen 240 kDa protein) (Mi2-alpha) (Zinc-finger helicase) (hZFH).

ATM_HUMAN
NC score	0.037723 (rank : 24)	θ value	1.06291 (rank : 25)
Query Neighborhood Hits	90	Target Neighborhood Hits	78	Shared Neighborhood Hits	4
SwissProt Accessions	Q13315, O15429, Q12758, Q16551, Q93007, Q9NP02, Q9UCX7	Gene names	ATM
Domain Architecture
Description	Serine-protein kinase ATM (EC 2.7.11.1) (Ataxia telangiectasia mutated) (A-T, mutated).

ICB1_MOUSE
NC score	0.037608 (rank : 25)	θ value	0.813845 (rank : 23)
Query Neighborhood Hits	90	Target Neighborhood Hits	69	Shared Neighborhood Hits	6
SwissProt Accessions	Q91YX0	Gene names	Icb1
Domain Architecture	No domain graphic available
Description	Induced by contact to basement membrane 1 protein homolog (ICB-1 protein).

SRRM2_MOUSE
NC score	0.037104 (rank : 26)	θ value	1.38821 (rank : 33)
Query Neighborhood Hits	90	Target Neighborhood Hits	1470	Shared Neighborhood Hits	30
SwissProt Accessions	Q8BTI8, Q3TBY5, Q569P9, Q80U37, Q8K383	Gene names	Srrm2, Kiaa0324
Domain Architecture	No domain graphic available
Description	Serine/arginine repetitive matrix protein 2.

ARAF_MOUSE
NC score	0.036554 (rank : 27)	θ value	0.0736092 (rank : 10)
Query Neighborhood Hits	90	Target Neighborhood Hits	874	Shared Neighborhood Hits	12
SwissProt Accessions	P04627, Q99J44, Q9CTT5, Q9D6R6, Q9DBU7	Gene names	Araf, A-raf, Araf1
Domain Architecture
Description	A-Raf proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1).

OFD1_HUMAN
NC score	0.036552 (rank : 28)	θ value	0.0961366 (rank : 12)
Query Neighborhood Hits	90	Target Neighborhood Hits	753	Shared Neighborhood Hits	14
SwissProt Accessions	O75665, O75666	Gene names	OFD1, CXorf5
Domain Architecture	No domain graphic available
Description	Oral-facial-digital syndrome 1 protein (Protein 71-7A).

STX18_HUMAN
NC score	0.036530 (rank : 29)	θ value	4.03905 (rank : 47)
Query Neighborhood Hits	90	Target Neighborhood Hits	225	Shared Neighborhood Hits	8
SwissProt Accessions	Q9P2W9, Q596L3, Q5TZP5	Gene names	STX18, GIG9
Domain Architecture	No domain graphic available
Description	Syntaxin-18 (Growth-inhibiting gene 9 protein).

DYHC_MOUSE
NC score	0.035832 (rank : 30)	θ value	1.06291 (rank : 27)
Query Neighborhood Hits	90	Target Neighborhood Hits	729	Shared Neighborhood Hits	13
SwissProt Accessions	Q9JHU4	Gene names	Dync1h1, Dnch1, Dnchc1
Domain Architecture
Description	Dynein heavy chain, cytosolic (DYHC) (Cytoplasmic dynein heavy chain 1) (DHC1) (Dynein heavy chain 1, cytoplasmic 1).

DYHC_HUMAN
NC score	0.035774 (rank : 31)	θ value	1.06291 (rank : 26)
Query Neighborhood Hits	90	Target Neighborhood Hits	733	Shared Neighborhood Hits	13
SwissProt Accessions	Q14204, Q6DKQ7, Q8WU28, Q92814, Q9Y4G5	Gene names	DYNC1H1, DNCH1, DNECL, KIAA0325
Domain Architecture	No domain graphic available
Description	Dynein heavy chain, cytosolic (DYHC) (Cytoplasmic dynein heavy chain 1) (DHC1) (Dynein heavy chain 1, cytoplasmic 1).

HGS_MOUSE
NC score	0.035134 (rank : 32)	θ value	0.47712 (rank : 20)
Query Neighborhood Hits	90	Target Neighborhood Hits	589	Shared Neighborhood Hits	18
SwissProt Accessions	Q99LI8, Q61691, Q8BQW3	Gene names	Hgs, Hrs
Domain Architecture	No domain graphic available
Description	Hepatocyte growth factor-regulated tyrosine kinase substrate.

NACAM_MOUSE
NC score	0.034999 (rank : 33)	θ value	0.813845 (rank : 24)
Query Neighborhood Hits	90	Target Neighborhood Hits	1866	Shared Neighborhood Hits	37
SwissProt Accessions	P70670	Gene names	Naca
Domain Architecture	No domain graphic available
Description	Nascent polypeptide-associated complex subunit alpha, muscle-specific form (Alpha-NAC, muscle-specific form).

ARAF_HUMAN
NC score	0.034392 (rank : 34)	θ value	0.279714 (rank : 14)
Query Neighborhood Hits	90	Target Neighborhood Hits	924	Shared Neighborhood Hits	14
SwissProt Accessions	P10398, P07557, Q5H9B3	Gene names	ARAF, ARAF1, PKS, PKS2
Domain Architecture
Description	A-Raf proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1) (A- raf-1) (Proto-oncogene Pks).

BRAF1_HUMAN
NC score	0.034021 (rank : 35)	θ value	0.0961366 (rank : 11)
Query Neighborhood Hits	90	Target Neighborhood Hits	883	Shared Neighborhood Hits	13
SwissProt Accessions	P15056, Q13878, Q9Y6T3	Gene names	BRAF, BRAF1, RAFB1
Domain Architecture
Description	B-Raf proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1) (p94) (v-Raf murine sarcoma viral oncogene homolog B1).

RBM16_HUMAN
NC score	0.033506 (rank : 36)	θ value	5.27518 (rank : 57)
Query Neighborhood Hits	90	Target Neighborhood Hits	300	Shared Neighborhood Hits	11
SwissProt Accessions	Q9UPN6, Q5TBU6, Q9BQN8, Q9BX43	Gene names	RBM16, KIAA1116
Domain Architecture
Description	Putative RNA-binding protein 16 (RNA-binding motif protein 16).

IF4B_MOUSE
NC score	0.033290 (rank : 37)	θ value	3.0926 (rank : 43)
Query Neighborhood Hits	90	Target Neighborhood Hits	368	Shared Neighborhood Hits	13
SwissProt Accessions	Q8BGD9, Q3TD64	Gene names	Eif4b
Domain Architecture	No domain graphic available
Description	Eukaryotic translation initiation factor 4B (eIF-4B).

PCIF1_HUMAN
NC score	0.030488 (rank : 38)	θ value	1.81305 (rank : 36)
Query Neighborhood Hits	90	Target Neighborhood Hits	92	Shared Neighborhood Hits	4
SwissProt Accessions	Q9H4Z3, Q9NT85	Gene names	PCIF1, C20orf67
Domain Architecture
Description	Phosphorylated CTD-interacting factor 1.

MAP9_MOUSE
NC score	0.030136 (rank : 39)	θ value	1.81305 (rank : 35)
Query Neighborhood Hits	90	Target Neighborhood Hits	529	Shared Neighborhood Hits	16
SwissProt Accessions	Q3TRR0, Q3UUD1, Q3UX85, Q3UXE7, Q5M8N8, Q6P8K1, Q8BMM4, Q8BYP7	Gene names	Map9, Asap
Domain Architecture	No domain graphic available
Description	Microtubule-associated protein 9 (Aster-associated protein).

IWS1_HUMAN
NC score	0.029093 (rank : 40)	θ value	1.38821 (rank : 30)
Query Neighborhood Hits	90	Target Neighborhood Hits	1241	Shared Neighborhood Hits	27
SwissProt Accessions	Q96ST2, Q6P157, Q8N3E8, Q96MI7, Q9NV97, Q9NWH8	Gene names	IWS1, IWS1L
Domain Architecture	No domain graphic available
Description	IWS1 homolog (IWS1-like protein).

CHD5_HUMAN
NC score	0.028899 (rank : 41)	θ value	1.81305 (rank : 34)
Query Neighborhood Hits	90	Target Neighborhood Hits	349	Shared Neighborhood Hits	13
SwissProt Accessions	Q8TDI0, O75032, Q5TG89, Q9UFR9	Gene names	CHD5
Domain Architecture	No domain graphic available
Description	Chromodomain helicase-DNA-binding protein 5 (EC 3.6.1.-) (ATP- dependent helicase CHD5) (CHD-5).

MDC1_HUMAN
NC score	0.028025 (rank : 42)	θ value	3.0926 (rank : 44)
Query Neighborhood Hits	90	Target Neighborhood Hits	1446	Shared Neighborhood Hits	31
SwissProt Accessions	Q14676, Q5JP55, Q5JP56, Q5ST83, Q68CQ3, Q86Z06, Q96QC2	Gene names	MDC1, KIAA0170, NFBD1
Domain Architecture	No domain graphic available
Description	Mediator of DNA damage checkpoint protein 1 (Nuclear factor with BRCT domains 1).

NFH_MOUSE
NC score	0.027968 (rank : 43)	θ value	0.365318 (rank : 17)
Query Neighborhood Hits	90	Target Neighborhood Hits	2247	Shared Neighborhood Hits	43
SwissProt Accessions	P19246, Q5SVF6, Q61959	Gene names	Nefh, Nfh
Domain Architecture
Description	Neurofilament triplet H protein (200 kDa neurofilament protein) (Neurofilament heavy polypeptide) (NF-H).

ATX2L_MOUSE
NC score	0.027815 (rank : 44)	θ value	3.0926 (rank : 41)
Query Neighborhood Hits	90	Target Neighborhood Hits	401	Shared Neighborhood Hits	15
SwissProt Accessions	Q7TQH0, Q80XN9, Q8K059	Gene names	Atxn2l, A2lp
Domain Architecture	No domain graphic available
Description	Ataxin-2-like protein.

ATX2_HUMAN
NC score	0.027150 (rank : 45)	θ value	6.88961 (rank : 63)
Query Neighborhood Hits	90	Target Neighborhood Hits	375	Shared Neighborhood Hits	19
SwissProt Accessions	Q99700, Q6ZQZ7, Q99493	Gene names	ATXN2, ATX2, SCA2, TNRC13
Domain Architecture	No domain graphic available
Description	Ataxin-2 (Spinocerebellar ataxia type 2 protein) (Trinucleotide repeat-containing gene 13 protein).

CGRE1_HUMAN
NC score	0.027008 (rank : 46)	θ value	5.27518 (rank : 52)
Query Neighborhood Hits	90	Target Neighborhood Hits	354	Shared Neighborhood Hits	8
SwissProt Accessions	Q99674	Gene names	CGREF1, CGR11
Domain Architecture	No domain graphic available
Description	Cell growth regulator with EF hand domain 1 (Cell growth regulatory gene 11 protein).

IF4B_HUMAN
NC score	0.026950 (rank : 47)	θ value	5.27518 (rank : 55)
Query Neighborhood Hits	90	Target Neighborhood Hits	417	Shared Neighborhood Hits	10
SwissProt Accessions	P23588	Gene names	EIF4B
Domain Architecture
Description	Eukaryotic translation initiation factor 4B (eIF-4B).

MBB1A_MOUSE
NC score	0.026880 (rank : 48)	θ value	8.99809 (rank : 80)
Query Neighborhood Hits	90	Target Neighborhood Hits	233	Shared Neighborhood Hits	15
SwissProt Accessions	Q7TPV4, O35851, Q80Y66, Q8R4X2, Q99KP0	Gene names	Mybbp1a, P160
Domain Architecture	No domain graphic available
Description	Myb-binding protein 1A (Myb-binding protein of 160 kDa).

SON_HUMAN
NC score	0.022939 (rank : 49)	θ value	6.88961 (rank : 73)
Query Neighborhood Hits	90	Target Neighborhood Hits	1568	Shared Neighborhood Hits	23
SwissProt Accessions	P18583, O14487, O95981, Q14120, Q9H7B1, Q9P070, Q9P072, Q9UKP9, Q9UPY0	Gene names	SON, C21orf50, DBP5, KIAA1019, NREBP
Domain Architecture
Description	SON protein (SON3) (Negative regulatory element-binding protein) (NRE- binding protein) (DBP-5) (Bax antagonist selected in saccharomyces 1) (BASS1).

CNTRB_MOUSE
NC score	0.022743 (rank : 50)	θ value	0.47712 (rank : 19)
Query Neighborhood Hits	90	Target Neighborhood Hits	1029	Shared Neighborhood Hits	15
SwissProt Accessions	Q8CB62, Q5NCF3	Gene names	Cntrob, Lip8
Domain Architecture	No domain graphic available
Description	Centrobin (LYST-interacting protein 8).

CD2L7_HUMAN
NC score	0.022671 (rank : 51)	θ value	0.0431538 (rank : 8)
Query Neighborhood Hits	90	Target Neighborhood Hits	1275	Shared Neighborhood Hits	32
SwissProt Accessions	Q9NYV4, O94978	Gene names	CRKRS, CRK7, KIAA0904
Domain Architecture
Description	Cell division cycle 2-related protein kinase 7 (EC 2.7.11.22) (CDC2- related protein kinase 7) (Cdc2-related kinase, arginine/serine-rich) (CrkRS).

RGS3_HUMAN
NC score	0.022314 (rank : 52)	θ value	1.06291 (rank : 29)
Query Neighborhood Hits	90	Target Neighborhood Hits	1375	Shared Neighborhood Hits	25
SwissProt Accessions	P49796, Q5VXC1, Q5VZ05, Q6ZRM5, Q8IUQ1, Q8NC47, Q8NFN4, Q8NFN5, Q8TD59, Q8TD68, Q8WXA0	Gene names	RGS3
Domain Architecture
Description	Regulator of G-protein signaling 3 (RGS3) (RGP3).

AFF2_HUMAN
NC score	0.021402 (rank : 53)	θ value	5.27518 (rank : 48)
Query Neighborhood Hits	90	Target Neighborhood Hits	218	Shared Neighborhood Hits	14
SwissProt Accessions	P51816, O43786, O60215, P78407, Q13521, Q14323, Q9UNA5	Gene names	AFF2, FMR2, OX19
Domain Architecture
Description	AF4/FMR2 family member 2 (Fragile X mental retardation 2 protein) (Protein FMR-2) (FMR2P) (Protein Ox19) (Fragile X E mental retardation syndrome protein).

CA103_MOUSE
NC score	0.021037 (rank : 54)	θ value	5.27518 (rank : 50)
Query Neighborhood Hits	90	Target Neighborhood Hits	37	Shared Neighborhood Hits	3
SwissProt Accessions	Q8CDD9, Q8C893	Gene names
Domain Architecture	No domain graphic available
Description	Protein C1orf103 homolog.

PCLO_HUMAN
NC score	0.020989 (rank : 55)	θ value	6.88961 (rank : 72)
Query Neighborhood Hits	90	Target Neighborhood Hits	2046	Shared Neighborhood Hits	39
SwissProt Accessions	Q9Y6V0, O43373, O60305, Q9BVC8, Q9UIV2, Q9Y6U9	Gene names	PCLO, ACZ, KIAA0559
Domain Architecture
Description	Protein piccolo (Aczonin).

UBF1_HUMAN
NC score	0.020843 (rank : 56)	θ value	8.99809 (rank : 90)
Query Neighborhood Hits	90	Target Neighborhood Hits	415	Shared Neighborhood Hits	9
SwissProt Accessions	P17480	Gene names	UBTF, UBF, UBF1
Domain Architecture
Description	Nucleolar transcription factor 1 (Upstream-binding factor 1) (UBF-1) (Autoantigen NOR-90).

CCD21_MOUSE
NC score	0.020805 (rank : 57)	θ value	5.27518 (rank : 51)
Query Neighborhood Hits	90	Target Neighborhood Hits	1135	Shared Neighborhood Hits	17
SwissProt Accessions	Q8BMK0, Q8BUF1, Q8K0E6	Gene names	Ccdc21
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 21.

SVIL_HUMAN
NC score	0.020696 (rank : 58)	θ value	6.88961 (rank : 74)
Query Neighborhood Hits	90	Target Neighborhood Hits	232	Shared Neighborhood Hits	10
SwissProt Accessions	O95425, O60611, O60612, Q5VZK5, Q5VZK6, Q9H1R7	Gene names	SVIL
Domain Architecture	No domain graphic available
Description	Supervillin (Archvillin) (p205/p250).

PIAS1_HUMAN
NC score	0.020494 (rank : 59)	θ value	5.27518 (rank : 56)
Query Neighborhood Hits	90	Target Neighborhood Hits	36	Shared Neighborhood Hits	4
SwissProt Accessions	O75925, Q99751, Q9UN02	Gene names	PIAS1, DDXBP1
Domain Architecture
Description	Protein inhibitor of activated STAT protein 1 (Gu-binding protein) (GBP) (RNA helicase II-binding protein) (DEAD/H box-binding protein 1).

VAV3_MOUSE
NC score	0.020431 (rank : 60)	θ value	1.81305 (rank : 38)
Query Neighborhood Hits	90	Target Neighborhood Hits	404	Shared Neighborhood Hits	8
SwissProt Accessions	Q9R0C8, Q7TS85	Gene names	Vav3
Domain Architecture
Description	Protein vav-3.

CHD8_HUMAN
NC score	0.020274 (rank : 61)	θ value	5.27518 (rank : 53)
Query Neighborhood Hits	90	Target Neighborhood Hits	235	Shared Neighborhood Hits	10
SwissProt Accessions	Q9HCK8, Q68DQ0, Q8N3Z9, Q8NCY4, Q8TBR9, Q96F26	Gene names	CHD8, HELSNF1, KIAA1564
Domain Architecture	No domain graphic available
Description	Chromodomain-helicase-DNA-binding protein 8 (EC 3.6.1.-) (ATP- dependent helicase CHD8) (CHD-8) (Helicase with SNF2 domain 1).

NOL1_HUMAN
NC score	0.019838 (rank : 62)	θ value	8.99809 (rank : 83)
Query Neighborhood Hits	90	Target Neighborhood Hits	74	Shared Neighborhood Hits	8
SwissProt Accessions	P46087	Gene names	NOL1
Domain Architecture
Description	Proliferating-cell nucleolar antigen p120 (Proliferation-associated nucleolar protein p120).

VAV3_HUMAN
NC score	0.019578 (rank : 63)	θ value	1.81305 (rank : 37)
Query Neighborhood Hits	90	Target Neighborhood Hits	398	Shared Neighborhood Hits	6
SwissProt Accessions	Q9UKW4, O95230, Q9Y5X8	Gene names	VAV3
Domain Architecture
Description	Protein vav-3.

RABE1_HUMAN
NC score	0.019229 (rank : 64)	θ value	1.38821 (rank : 32)
Query Neighborhood Hits	90	Target Neighborhood Hits	1104	Shared Neighborhood Hits	14
SwissProt Accessions	Q15276, O95369, Q8IVX3	Gene names	RABEP1, RABPT5, RABPT5A
Domain Architecture
Description	Rab GTPase-binding effector protein 1 (Rabaptin-5) (Rabaptin-5alpha) (Rabaptin-4) (NY-REN-17 antigen).

ANR33_MOUSE
NC score	0.019150 (rank : 65)	θ value	5.27518 (rank : 49)
Query Neighborhood Hits	90	Target Neighborhood Hits	225	Shared Neighborhood Hits	4
SwissProt Accessions	Q8BXP5, Q8BXP4, Q8R1Z1	Gene names	Ankrd33
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 33.

FBW1B_HUMAN
NC score	0.018405 (rank : 66)	θ value	2.36792 (rank : 40)
Query Neighborhood Hits	90	Target Neighborhood Hits	327	Shared Neighborhood Hits	7
SwissProt Accessions	Q9UKB1, Q9P2S8, Q9P2S9, Q9Y4C6	Gene names	FBXW11, BTRCP2, FBW1B, FBXW1B, KIAA0696
Domain Architecture
Description	F-box/WD repeat protein 11 (F-box/WD repeat protein 1B) (F-box and WD repeats protein beta-TrCP2).

PI5PA_HUMAN
NC score	0.018287 (rank : 67)	θ value	8.99809 (rank : 84)
Query Neighborhood Hits	90	Target Neighborhood Hits	749	Shared Neighborhood Hits	17
SwissProt Accessions	Q15735, Q32M61, Q6ZTH6, Q8N902, Q9UDT9	Gene names	PIB5PA, PIPP
Domain Architecture
Description	Phosphatidylinositol 4,5-bisphosphate 5-phosphatase A (EC 3.1.3.56).

CAND2_MOUSE
NC score	0.017019 (rank : 68)	θ value	6.88961 (rank : 64)
Query Neighborhood Hits	90	Target Neighborhood Hits	44	Shared Neighborhood Hits	3
SwissProt Accessions	Q6ZQ73, Q6PHT7	Gene names	Cand2, Kiaa0667, Tip120b
Domain Architecture	No domain graphic available
Description	Cullin-associated NEDD8-dissociated protein 2 (Cullin-associated and neddylation-dissociated protein 2) (p120 CAND2) (TBP-interacting protein TIP120B) (TBP-interacting protein of 120 kDa B).

PRRT3_HUMAN
NC score	0.016859 (rank : 69)	θ value	8.99809 (rank : 86)
Query Neighborhood Hits	90	Target Neighborhood Hits	998	Shared Neighborhood Hits	18
SwissProt Accessions	Q5FWE3, Q49AD0, Q6UXY6, Q8NBC9	Gene names	PRRT3, UNQ5823/PRO19642
Domain Architecture	No domain graphic available
Description	Proline-rich transmembrane protein 3.

PIAS1_MOUSE
NC score	0.016701 (rank : 70)	θ value	8.99809 (rank : 85)
Query Neighborhood Hits	90	Target Neighborhood Hits	32	Shared Neighborhood Hits	4
SwissProt Accessions	O88907, Q8C6H5	Gene names	Pias1, Ddxbp1
Domain Architecture
Description	Protein inhibitor of activated STAT protein 1 (DEAD/H box-binding protein 1).

EXOSX_HUMAN
NC score	0.015868 (rank : 71)	θ value	6.88961 (rank : 65)
Query Neighborhood Hits	90	Target Neighborhood Hits	30	Shared Neighborhood Hits	2
SwissProt Accessions	Q01780, Q15158	Gene names	EXOSC10, PMSCL, PMSCL2
Domain Architecture
Description	Exosome component 10 (Polymyositis/scleroderma autoantigen 2) (Autoantigen PM/Scl 2) (Polymyositis/scleroderma autoantigen 100 kDa) (PM/Scl-100) (P100 polymyositis-scleroderma overlap syndrome- associated autoantigen).

RP1_MOUSE
NC score	0.014801 (rank : 72)	θ value	8.99809 (rank : 89)
Query Neighborhood Hits	90	Target Neighborhood Hits	104	Shared Neighborhood Hits	3
SwissProt Accessions	P56716	Gene names	Rp1, Orp1, Rp1h
Domain Architecture
Description	Oxygen-regulated protein 1 (Retinitis pigmentosa RP1 protein homolog).

FBW1A_HUMAN
NC score	0.013615 (rank : 73)	θ value	6.88961 (rank : 66)
Query Neighborhood Hits	90	Target Neighborhood Hits	329	Shared Neighborhood Hits	7
SwissProt Accessions	Q9Y297, Q9Y213	Gene names	BTRC, BTRCP, FBW1A, FBXW1A
Domain Architecture
Description	F-box/WD repeat protein 1A (F-box and WD repeats protein beta-TrCP) (E3RSIkappaB) (pIkappaBalpha-E3 receptor subunit).

XKR7_MOUSE
NC score	0.013298 (rank : 74)	θ value	5.27518 (rank : 60)
Query Neighborhood Hits	90	Target Neighborhood Hits	146	Shared Neighborhood Hits	4
SwissProt Accessions	Q5GH64	Gene names	Xkr7, Xrg7
Domain Architecture	No domain graphic available
Description	XK-related protein 7.

AP3B1_MOUSE
NC score	0.012960 (rank : 75)	θ value	8.99809 (rank : 75)
Query Neighborhood Hits	90	Target Neighborhood Hits	302	Shared Neighborhood Hits	8
SwissProt Accessions	Q9Z1T1, Q91YR4	Gene names	Ap3b1
Domain Architecture
Description	AP-3 complex subunit beta-1 (Adapter-related protein complex 3 beta-1 subunit) (Beta3A-adaptin) (Adaptor protein complex AP-3 beta-1 subunit) (Clathrin assembly protein complex 3 beta-1 large chain).

ANK2_HUMAN
NC score	0.012669 (rank : 76)	θ value	6.88961 (rank : 62)
Query Neighborhood Hits	90	Target Neighborhood Hits	1615	Shared Neighborhood Hits	32
SwissProt Accessions	Q01484, Q01485	Gene names	ANK2
Domain Architecture
Description	Ankyrin-2 (Brain ankyrin) (Ankyrin-B) (Ankyrin, nonerythroid).

GGA2_HUMAN
NC score	0.011719 (rank : 77)	θ value	8.99809 (rank : 78)
Query Neighborhood Hits	90	Target Neighborhood Hits	114	Shared Neighborhood Hits	7
SwissProt Accessions	Q9UJY4, O14564, Q9NYN2, Q9UPS2	Gene names	GGA2, KIAA1080
Domain Architecture
Description	ADP-ribosylation factor-binding protein GGA2 (Golgi-localized, gamma ear-containing, ARF-binding protein 2) (Gamma-adaptin-related protein 2) (VHS domain and ear domain of gamma-adaptin) (Vear).

CH1B1_MOUSE
NC score	0.011336 (rank : 78)	θ value	8.99809 (rank : 77)
Query Neighborhood Hits	90	Target Neighborhood Hits	19	Shared Neighborhood Hits	2
SwissProt Accessions	Q99LU0, Q3UB77, Q9CXR5	Gene names	Chmp1b1, Chmp1b
Domain Architecture	No domain graphic available
Description	Charged multivesicular body protein 1b-1 (Chromatin-modifying protein 1b-1) (CHMP1b-1).

PANK2_HUMAN
NC score	0.011232 (rank : 79)	θ value	6.88961 (rank : 71)
Query Neighborhood Hits	90	Target Neighborhood Hits	21	Shared Neighborhood Hits	2
SwissProt Accessions	Q9BZ23, Q5T7I2, Q8N7Q4, Q8TCR5, Q9BYW5, Q9HAF2	Gene names	PANK2, C20orf48
Domain Architecture
Description	Pantothenate kinase 2, mitochondrial precursor (EC 2.7.1.33) (Pantothenic acid kinase 2) (hPANK2).

MNDA_HUMAN
NC score	0.011087 (rank : 80)	θ value	8.99809 (rank : 81)
Query Neighborhood Hits	90	Target Neighborhood Hits	76	Shared Neighborhood Hits	8
SwissProt Accessions	P41218	Gene names	MNDA
Domain Architecture
Description	Myeloid cell nuclear differentiation antigen.

RAVR1_MOUSE
NC score	0.010456 (rank : 81)	θ value	8.99809 (rank : 87)
Query Neighborhood Hits	90	Target Neighborhood Hits	179	Shared Neighborhood Hits	6
SwissProt Accessions	Q9CW46, Q5DTT6, Q811K0, Q8C3Z1, Q8CA14	Gene names	Raver1, Kiaa1978
Domain Architecture	No domain graphic available
Description	Ribonucleoprotein PTB-binding 1 (Protein raver-1).

LRRK1_MOUSE
NC score	0.010367 (rank : 82)	θ value	8.99809 (rank : 79)
Query Neighborhood Hits	90	Target Neighborhood Hits	1267	Shared Neighborhood Hits	11
SwissProt Accessions	Q3UHC2, Q3U476, Q66JQ4, Q6GQR9, Q6NZF5, Q6ZPI4, Q8BKP3, Q8BU93, Q8BUY0, Q8BVV2, Q8R085	Gene names	Lrrk1, Kiaa1790
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat serine/threonine-protein kinase 1 (EC 2.7.11.1).

TSH2_MOUSE
NC score	0.010299 (rank : 83)	θ value	5.27518 (rank : 59)
Query Neighborhood Hits	90	Target Neighborhood Hits	467	Shared Neighborhood Hits	3
SwissProt Accessions	Q68FE9, Q5DTF1, Q6AXH5, Q9JL71	Gene names	Tshz2, Kiaa4248, Sdccag33l, Tsh2, Zfp218, Znf218
Domain Architecture	No domain graphic available
Description	Teashirt homolog 2 (Zinc finger protein 218) (SDCCAG33-like protein).

MAST4_HUMAN
NC score	0.009514 (rank : 84)	θ value	6.88961 (rank : 70)
Query Neighborhood Hits	90	Target Neighborhood Hits	1804	Shared Neighborhood Hits	33
SwissProt Accessions	O15021, Q6ZN07, Q96LY3	Gene names	MAST4, KIAA0303
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase 4 (EC 2.7.11.1).

RFIP4_HUMAN
NC score	0.008483 (rank : 85)	θ value	8.99809 (rank : 88)
Query Neighborhood Hits	90	Target Neighborhood Hits	785	Shared Neighborhood Hits	11
SwissProt Accessions	Q86YS3, Q8N829, Q8NDT7, Q969D8	Gene names	RAB11FIP4, KIAA1821
Domain Architecture	No domain graphic available
Description	Rab11 family-interacting protein 4 (Rab11-FIP4).

ERR1_HUMAN
NC score	0.008298 (rank : 86)	θ value	3.0926 (rank : 42)
Query Neighborhood Hits	90	Target Neighborhood Hits	157	Shared Neighborhood Hits	5
SwissProt Accessions	P11474, Q14514	Gene names	ESRRA, ERR1, ESRL1, NR3B1
Domain Architecture
Description	Steroid hormone receptor ERR1 (Estrogen-related receptor, alpha) (ERR- alpha) (Estrogen receptor-like 1).

BICD1_MOUSE
NC score	0.007655 (rank : 87)	θ value	8.99809 (rank : 76)
Query Neighborhood Hits	90	Target Neighborhood Hits	837	Shared Neighborhood Hits	13
SwissProt Accessions	Q8BR07, O55206, Q8BQ18, Q8BRR8, Q8C4D3, Q8CAK6, Q8R2J4, Q8R2J5, Q8R2J6, Q91YP7	Gene names	Bicd1
Domain Architecture	No domain graphic available
Description	Cytoskeleton-like bicaudal D protein homolog 1.

GAK4_HUMAN
NC score	0.007291 (rank : 88)	θ value	6.88961 (rank : 67)
Query Neighborhood Hits	90	Target Neighborhood Hits	415	Shared Neighborhood Hits	10
SwissProt Accessions	P63126, Q9UKH4	Gene names
Domain Architecture	No domain graphic available
Description	HERV-K_6q14.1 provirus ancestral Gag polyprotein (Gag polyprotein) (HERV-K109 Gag protein) (HERV-K(C6) Gag protein) [Contains: Matrix protein; Capsid protein; Nucleocapsid protein].

MYH14_MOUSE
NC score	0.005078 (rank : 89)	θ value	8.99809 (rank : 82)
Query Neighborhood Hits	90	Target Neighborhood Hits	1225	Shared Neighborhood Hits	15
SwissProt Accessions	Q6URW6, Q80V64, Q80ZE6	Gene names	Myh14
Domain Architecture	No domain graphic available
Description	Myosin-14 (Myosin heavy chain, nonmuscle IIc) (Nonmuscle myosin heavy chain IIc) (NMHC II-C).

LAMB1_MOUSE
NC score	0.004338 (rank : 90)	θ value	6.88961 (rank : 69)
Query Neighborhood Hits	90	Target Neighborhood Hits	919	Shared Neighborhood Hits	10
SwissProt Accessions	P02469	Gene names	Lamb1-1, Lamb-1
Domain Architecture
Description	Laminin beta-1 chain precursor (Laminin B1 chain).

ZSCA1_HUMAN
NC score	0.001432 (rank : 91)	θ value	5.27518 (rank : 61)
Query Neighborhood Hits	90	Target Neighborhood Hits	724	Shared Neighborhood Hits	3
SwissProt Accessions	Q8NBB4, Q6WLH8, Q86WS8	Gene names	ZSCAN1
Domain Architecture	No domain graphic available
Description	Zinc finger and SCAN domain-containing protein 1.