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Network neighborhood for query Sequence : EXOSX_HUMAN

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EXOSX_HUMAN
SwissProt Accessions	Q01780, Q15158	Gene names	EXOSC10, PMSCL, PMSCL2
Domain Architecture
Description	Exosome component 10 (Polymyositis/scleroderma autoantigen 2) (Autoantigen PM/Scl 2) (Polymyositis/scleroderma autoantigen 100 kDa) (PM/Scl-100) (P100 polymyositis-scleroderma overlap syndrome- associated autoantigen).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

EXOSX_HUMAN
θ value	0 (rank : 1)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	30	Target Neighborhood Hits	30	Shared Neighborhood Hits	30
SwissProt Accessions	Q01780, Q15158	Gene names	EXOSC10, PMSCL, PMSCL2
Domain Architecture
Description	Exosome component 10 (Polymyositis/scleroderma autoantigen 2) (Autoantigen PM/Scl 2) (Polymyositis/scleroderma autoantigen 100 kDa) (PM/Scl-100) (P100 polymyositis-scleroderma overlap syndrome- associated autoantigen).

EXOSX_MOUSE
θ value	0 (rank : 2)	NC score	0.989576 (rank : 2)
Query Neighborhood Hits	30	Target Neighborhood Hits	36	Shared Neighborhood Hits	7
SwissProt Accessions	P56960, Q9QYS8, Q9R0B1	Gene names	Exosc10, Pmscl2
Domain Architecture
Description	Exosome component 10 (Polymyositis/scleroderma autoantigen 2 homolog) (Autoantigen PM/Scl 2 homolog).

NFM_MOUSE
θ value	0.163984 (rank : 3)	NC score	0.021547 (rank : 9)
Query Neighborhood Hits	30	Target Neighborhood Hits	1159	Shared Neighborhood Hits	11
SwissProt Accessions	P08553, Q61961	Gene names	Nef3, Nefm, Nfm
Domain Architecture
Description	Neurofilament triplet M protein (160 kDa neurofilament protein) (Neurofilament medium polypeptide) (NF-M).

MYH9_MOUSE
θ value	0.21417 (rank : 4)	NC score	0.017290 (rank : 15)
Query Neighborhood Hits	30	Target Neighborhood Hits	1829	Shared Neighborhood Hits	11
SwissProt Accessions	Q8VDD5	Gene names	Myh9
Domain Architecture	No domain graphic available
Description	Myosin-9 (Myosin heavy chain, nonmuscle IIa) (Nonmuscle myosin heavy chain IIa) (NMMHC II-a) (NMMHC-IIA) (Cellular myosin heavy chain, type A) (Nonmuscle myosin heavy chain-A) (NMMHC-A).

NFM_HUMAN
θ value	0.21417 (rank : 5)	NC score	0.021049 (rank : 12)
Query Neighborhood Hits	30	Target Neighborhood Hits	1328	Shared Neighborhood Hits	11
SwissProt Accessions	P07197	Gene names	NEF3, NEFM, NFM
Domain Architecture
Description	Neurofilament triplet M protein (160 kDa neurofilament protein) (Neurofilament medium polypeptide) (NF-M) (Neurofilament 3).

TERF1_HUMAN
θ value	0.21417 (rank : 6)	NC score	0.056100 (rank : 3)
Query Neighborhood Hits	30	Target Neighborhood Hits	83	Shared Neighborhood Hits	2
SwissProt Accessions	P54274, Q15553, Q93029	Gene names	TERF1, PIN2, TRF, TRF1
Domain Architecture
Description	Telomeric repeat-binding factor 1 (TTAGGG repeat-binding factor 1) (NIMA-interacting protein 2) (Telomeric protein Pin2/TRF1).

ELOA1_HUMAN
θ value	0.813845 (rank : 7)	NC score	0.031949 (rank : 7)
Query Neighborhood Hits	30	Target Neighborhood Hits	388	Shared Neighborhood Hits	5
SwissProt Accessions	Q14241, Q8IXH1	Gene names	TCEB3
Domain Architecture
Description	Transcription elongation factor B polypeptide 3 (RNA polymerase II transcription factor SIII subunit A1) (SIII p110) (Elongin-A) (EloA) (Elongin 110 kDa subunit).

ATF6B_MOUSE
θ value	1.38821 (rank : 8)	NC score	0.047839 (rank : 4)
Query Neighborhood Hits	30	Target Neighborhood Hits	97	Shared Neighborhood Hits	3
SwissProt Accessions	O35451	Gene names	Crebl1
Domain Architecture
Description	Cyclic AMP-dependent transcription factor ATF-6 beta (Activating transcription factor 6 beta) (ATF6-beta) (cAMP-responsive element- binding protein-like 1) (cAMP response element-binding protein-related protein) (Creb-rp).

GON4L_HUMAN
θ value	1.38821 (rank : 9)	NC score	0.028406 (rank : 8)
Query Neighborhood Hits	30	Target Neighborhood Hits	555	Shared Neighborhood Hits	7
SwissProt Accessions	Q3T8J9, Q3T8J8, Q5VYZ5, Q5W0D5, Q6AWA6, Q6P1Q6, Q7Z3L3, Q8IY79, Q9BQI1, Q9HCG6	Gene names	GON4L, GON4, KIAA1606
Domain Architecture	No domain graphic available
Description	GON-4-like protein (GON-4 homolog).

CF118_HUMAN
θ value	2.36792 (rank : 10)	NC score	0.041152 (rank : 5)
Query Neighborhood Hits	30	Target Neighborhood Hits	154	Shared Neighborhood Hits	5
SwissProt Accessions	Q5T5N4, Q8TC11	Gene names	C6orf118
Domain Architecture	No domain graphic available
Description	Protein C6orf118.

ITSN1_MOUSE
θ value	2.36792 (rank : 11)	NC score	0.011087 (rank : 22)
Query Neighborhood Hits	30	Target Neighborhood Hits	1669	Shared Neighborhood Hits	9
SwissProt Accessions	Q9Z0R4, Q9R143	Gene names	Itsn1, Ese1, Itsn
Domain Architecture
Description	Intersectin-1 (EH and SH3 domains protein 1).

TMEM1_HUMAN
θ value	2.36792 (rank : 12)	NC score	0.039311 (rank : 6)
Query Neighborhood Hits	30	Target Neighborhood Hits	18	Shared Neighborhood Hits	2
SwissProt Accessions	P48553, Q9UMD4, Q9Y4L3	Gene names	TMEM1, EHOC1
Domain Architecture	No domain graphic available
Description	Transmembrane protein 1 (Epilepsy holoprosencephaly candidate 1 protein) (EHOC-1) (GT334 protein).

FAK2_HUMAN
θ value	3.0926 (rank : 13)	NC score	0.008712 (rank : 25)
Query Neighborhood Hits	30	Target Neighborhood Hits	847	Shared Neighborhood Hits	6
SwissProt Accessions	Q14289, Q13475, Q14290, Q16709	Gene names	PTK2B, FAK2, PYK2, RAFTK
Domain Architecture
Description	Protein tyrosine kinase 2 beta (EC 2.7.10.2) (Focal adhesion kinase 2) (FADK 2) (Proline-rich tyrosine kinase 2) (Cell adhesion kinase beta) (CAK beta) (Calcium-dependent tyrosine kinase) (CADTK) (Related adhesion focal tyrosine kinase) (RAFTK).

FAK2_MOUSE
θ value	3.0926 (rank : 14)	NC score	0.008758 (rank : 24)
Query Neighborhood Hits	30	Target Neighborhood Hits	851	Shared Neighborhood Hits	7
SwissProt Accessions	Q9QVP9	Gene names	Ptk2b, Fak2, Pyk2, Raftk
Domain Architecture	No domain graphic available
Description	Protein tyrosine kinase 2 beta (EC 2.7.10.2) (Focal adhesion kinase 2) (FADK 2) (Proline-rich tyrosine kinase 2) (Cell adhesion kinase beta) (CAK beta) (Calcium-dependent tyrosine kinase) (CADTK) (Related adhesion focal tyrosine kinase) (RAFTK).

ANPRA_HUMAN
θ value	4.03905 (rank : 15)	NC score	0.007040 (rank : 27)
Query Neighborhood Hits	30	Target Neighborhood Hits	612	Shared Neighborhood Hits	5
SwissProt Accessions	P16066, Q6P4Q3	Gene names	NPR1, ANPRA
Domain Architecture
Description	Atrial natriuretic peptide receptor A precursor (ANP-A) (ANPRA) (GC-A) (Guanylate cyclase) (EC 4.6.1.2) (NPR-A) (Atrial natriuretic peptide A-type receptor).

DJC12_HUMAN
θ value	4.03905 (rank : 16)	NC score	0.019274 (rank : 13)
Query Neighborhood Hits	30	Target Neighborhood Hits	141	Shared Neighborhood Hits	2
SwissProt Accessions	Q9UKB3, Q9UKB2	Gene names	DNAJC12, JDP1
Domain Architecture
Description	DnaJ homolog subfamily C member 12 (J domain-containing protein 1).

K1718_HUMAN
θ value	4.03905 (rank : 17)	NC score	0.013626 (rank : 19)
Query Neighborhood Hits	30	Target Neighborhood Hits	114	Shared Neighborhood Hits	3
SwissProt Accessions	Q6ZMT4, Q6MZL8, Q9C0E5	Gene names	KIAA1718
Domain Architecture	No domain graphic available
Description	Protein KIAA1718.

MYH9_HUMAN
θ value	4.03905 (rank : 18)	NC score	0.012595 (rank : 20)
Query Neighborhood Hits	30	Target Neighborhood Hits	1762	Shared Neighborhood Hits	11
SwissProt Accessions	P35579, O60805	Gene names	MYH9
Domain Architecture
Description	Myosin-9 (Myosin heavy chain, nonmuscle IIa) (Nonmuscle myosin heavy chain IIa) (NMMHC II-a) (NMMHC-IIA) (Cellular myosin heavy chain, type A) (Nonmuscle myosin heavy chain-A) (NMMHC-A).

M4K2_HUMAN
θ value	5.27518 (rank : 19)	NC score	0.002718 (rank : 30)
Query Neighborhood Hits	30	Target Neighborhood Hits	850	Shared Neighborhood Hits	5
SwissProt Accessions	Q12851	Gene names	MAP4K2, GCK, RAB8IP
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase kinase 2 (EC 2.7.11.1) (MAPK/ERK kinase kinase kinase 2) (MEK kinase kinase 2) (MEKKK 2) (Germinal center kinase) (GC kinase) (Rab8-interacting protein) (B lymphocyte serine/threonine-protein kinase).

NEBU_HUMAN
θ value	5.27518 (rank : 20)	NC score	0.014143 (rank : 18)
Query Neighborhood Hits	30	Target Neighborhood Hits	420	Shared Neighborhood Hits	3
SwissProt Accessions	P20929, Q15346	Gene names	NEB
Domain Architecture
Description	Nebulin.

NPT2A_HUMAN
θ value	5.27518 (rank : 21)	NC score	0.021153 (rank : 10)
Query Neighborhood Hits	30	Target Neighborhood Hits	12	Shared Neighborhood Hits	3
SwissProt Accessions	Q06495	Gene names	SLC34A1, NPT2, SLC17A2
Domain Architecture
Description	Sodium-dependent phosphate transport protein 2A (Sodium/phosphate cotransporter 2A) (Na(+)/Pi cotransporter 2A) (Sodium-phosphate transport protein 2A) (Na(+)-dependent phosphate cotransporter 2A) (NaPi-2a) (Solute carrier family 34 member 1) (NaPi-3).

NPT2A_MOUSE
θ value	5.27518 (rank : 22)	NC score	0.021120 (rank : 11)
Query Neighborhood Hits	30	Target Neighborhood Hits	13	Shared Neighborhood Hits	3
SwissProt Accessions	Q60825, Q62110, Q62111, Q62112, Q62113, Q62114, Q62115, Q62116, Q62564	Gene names	Slc34a1, Npt2, Slc17a2
Domain Architecture
Description	Sodium-dependent phosphate transport protein 2A (Sodium/phosphate cotransporter 2A) (Na(+)/Pi cotransporter 2A) (Sodium-phosphate transport protein 2A) (Na(+)-dependent phosphate cotransporter 2A) (NaPi-2a) (Solute carrier family 34 member 1) (NaPi-7).

SKIL_HUMAN
θ value	5.27518 (rank : 23)	NC score	0.018500 (rank : 14)
Query Neighborhood Hits	30	Target Neighborhood Hits	460	Shared Neighborhood Hits	8
SwissProt Accessions	P12757, O00464, P12756, Q07501	Gene names	SKIL, SNO
Domain Architecture
Description	Ski-like protein (Ski-related protein) (Ski-related oncogene).

TXND2_HUMAN
θ value	5.27518 (rank : 24)	NC score	0.015135 (rank : 17)
Query Neighborhood Hits	30	Target Neighborhood Hits	793	Shared Neighborhood Hits	5
SwissProt Accessions	Q86VQ3, Q8N7U4, Q96RX3, Q9H0L8	Gene names	TXNDC2, SPTRX, SPTRX1
Domain Architecture	No domain graphic available
Description	Thioredoxin domain-containing protein 2 (Spermatid-specific thioredoxin-1) (Sptrx-1).

NOTC1_MOUSE
θ value	6.88961 (rank : 25)	NC score	0.007314 (rank : 26)
Query Neighborhood Hits	30	Target Neighborhood Hits	916	Shared Neighborhood Hits	4
SwissProt Accessions	Q01705, Q06007, Q61905, Q99JC2, Q9QW58, Q9R0X7	Gene names	Notch1, Motch
Domain Architecture
Description	Neurogenic locus notch homolog protein 1 precursor (Notch 1) (Motch A) (mT14) (p300) [Contains: Notch 1 extracellular truncation; Notch 1 intracellular domain].

SYMPK_HUMAN
θ value	6.88961 (rank : 26)	NC score	0.015868 (rank : 16)
Query Neighborhood Hits	30	Target Neighborhood Hits	90	Shared Neighborhood Hits	2
SwissProt Accessions	Q92797, O00521, O00689, O00733, Q59GT5, Q8N2U5	Gene names	SYMPK, SPK
Domain Architecture	No domain graphic available
Description	Symplekin.

CD7_HUMAN
θ value	8.99809 (rank : 27)	NC score	0.011377 (rank : 21)
Query Neighborhood Hits	30	Target Neighborhood Hits	190	Shared Neighborhood Hits	2
SwissProt Accessions	P09564	Gene names	CD7
Domain Architecture
Description	T-cell antigen CD7 precursor (GP40) (T-cell leukemia antigen) (TP41) (Leu-9).

DESP_HUMAN
θ value	8.99809 (rank : 28)	NC score	0.009449 (rank : 23)
Query Neighborhood Hits	30	Target Neighborhood Hits	1470	Shared Neighborhood Hits	9
SwissProt Accessions	P15924, O75993, Q14189, Q9UHN4	Gene names	DSP
Domain Architecture
Description	Desmoplakin (DP) (250/210 kDa paraneoplastic pemphigus antigen).

NMDE1_MOUSE
θ value	8.99809 (rank : 29)	NC score	0.005376 (rank : 28)
Query Neighborhood Hits	30	Target Neighborhood Hits	84	Shared Neighborhood Hits	2
SwissProt Accessions	P35436	Gene names	Grin2a
Domain Architecture	No domain graphic available
Description	Glutamate [NMDA] receptor subunit epsilon 1 precursor (N-methyl D- aspartate receptor subtype 2A) (NR2A) (NMDAR2A).

NOTC1_HUMAN
θ value	8.99809 (rank : 30)	NC score	0.003801 (rank : 29)
Query Neighborhood Hits	30	Target Neighborhood Hits	906	Shared Neighborhood Hits	3
SwissProt Accessions	P46531	Gene names	NOTCH1, TAN1
Domain Architecture
Description	Neurogenic locus notch homolog protein 1 precursor (Notch 1) (hN1) (Translocation-associated notch protein TAN-1) [Contains: Notch 1 extracellular truncation; Notch 1 intracellular domain].

Hits sorted by NC score

EXOSX_HUMAN
NC score	0.999962 (rank : 1)	θ value	0 (rank : 1)
Query Neighborhood Hits	30	Target Neighborhood Hits	30	Shared Neighborhood Hits	30
SwissProt Accessions	Q01780, Q15158	Gene names	EXOSC10, PMSCL, PMSCL2
Domain Architecture
Description	Exosome component 10 (Polymyositis/scleroderma autoantigen 2) (Autoantigen PM/Scl 2) (Polymyositis/scleroderma autoantigen 100 kDa) (PM/Scl-100) (P100 polymyositis-scleroderma overlap syndrome- associated autoantigen).

EXOSX_MOUSE
NC score	0.989576 (rank : 2)	θ value	0 (rank : 2)
Query Neighborhood Hits	30	Target Neighborhood Hits	36	Shared Neighborhood Hits	7
SwissProt Accessions	P56960, Q9QYS8, Q9R0B1	Gene names	Exosc10, Pmscl2
Domain Architecture
Description	Exosome component 10 (Polymyositis/scleroderma autoantigen 2 homolog) (Autoantigen PM/Scl 2 homolog).

TERF1_HUMAN
NC score	0.056100 (rank : 3)	θ value	0.21417 (rank : 6)
Query Neighborhood Hits	30	Target Neighborhood Hits	83	Shared Neighborhood Hits	2
SwissProt Accessions	P54274, Q15553, Q93029	Gene names	TERF1, PIN2, TRF, TRF1
Domain Architecture
Description	Telomeric repeat-binding factor 1 (TTAGGG repeat-binding factor 1) (NIMA-interacting protein 2) (Telomeric protein Pin2/TRF1).

ATF6B_MOUSE
NC score	0.047839 (rank : 4)	θ value	1.38821 (rank : 8)
Query Neighborhood Hits	30	Target Neighborhood Hits	97	Shared Neighborhood Hits	3
SwissProt Accessions	O35451	Gene names	Crebl1
Domain Architecture
Description	Cyclic AMP-dependent transcription factor ATF-6 beta (Activating transcription factor 6 beta) (ATF6-beta) (cAMP-responsive element- binding protein-like 1) (cAMP response element-binding protein-related protein) (Creb-rp).

CF118_HUMAN
NC score	0.041152 (rank : 5)	θ value	2.36792 (rank : 10)
Query Neighborhood Hits	30	Target Neighborhood Hits	154	Shared Neighborhood Hits	5
SwissProt Accessions	Q5T5N4, Q8TC11	Gene names	C6orf118
Domain Architecture	No domain graphic available
Description	Protein C6orf118.

TMEM1_HUMAN
NC score	0.039311 (rank : 6)	θ value	2.36792 (rank : 12)
Query Neighborhood Hits	30	Target Neighborhood Hits	18	Shared Neighborhood Hits	2
SwissProt Accessions	P48553, Q9UMD4, Q9Y4L3	Gene names	TMEM1, EHOC1
Domain Architecture	No domain graphic available
Description	Transmembrane protein 1 (Epilepsy holoprosencephaly candidate 1 protein) (EHOC-1) (GT334 protein).

ELOA1_HUMAN
NC score	0.031949 (rank : 7)	θ value	0.813845 (rank : 7)
Query Neighborhood Hits	30	Target Neighborhood Hits	388	Shared Neighborhood Hits	5
SwissProt Accessions	Q14241, Q8IXH1	Gene names	TCEB3
Domain Architecture
Description	Transcription elongation factor B polypeptide 3 (RNA polymerase II transcription factor SIII subunit A1) (SIII p110) (Elongin-A) (EloA) (Elongin 110 kDa subunit).

GON4L_HUMAN
NC score	0.028406 (rank : 8)	θ value	1.38821 (rank : 9)
Query Neighborhood Hits	30	Target Neighborhood Hits	555	Shared Neighborhood Hits	7
SwissProt Accessions	Q3T8J9, Q3T8J8, Q5VYZ5, Q5W0D5, Q6AWA6, Q6P1Q6, Q7Z3L3, Q8IY79, Q9BQI1, Q9HCG6	Gene names	GON4L, GON4, KIAA1606
Domain Architecture	No domain graphic available
Description	GON-4-like protein (GON-4 homolog).

NFM_MOUSE
NC score	0.021547 (rank : 9)	θ value	0.163984 (rank : 3)
Query Neighborhood Hits	30	Target Neighborhood Hits	1159	Shared Neighborhood Hits	11
SwissProt Accessions	P08553, Q61961	Gene names	Nef3, Nefm, Nfm
Domain Architecture
Description	Neurofilament triplet M protein (160 kDa neurofilament protein) (Neurofilament medium polypeptide) (NF-M).

NPT2A_HUMAN
NC score	0.021153 (rank : 10)	θ value	5.27518 (rank : 21)
Query Neighborhood Hits	30	Target Neighborhood Hits	12	Shared Neighborhood Hits	3
SwissProt Accessions	Q06495	Gene names	SLC34A1, NPT2, SLC17A2
Domain Architecture
Description	Sodium-dependent phosphate transport protein 2A (Sodium/phosphate cotransporter 2A) (Na(+)/Pi cotransporter 2A) (Sodium-phosphate transport protein 2A) (Na(+)-dependent phosphate cotransporter 2A) (NaPi-2a) (Solute carrier family 34 member 1) (NaPi-3).

NPT2A_MOUSE
NC score	0.021120 (rank : 11)	θ value	5.27518 (rank : 22)
Query Neighborhood Hits	30	Target Neighborhood Hits	13	Shared Neighborhood Hits	3
SwissProt Accessions	Q60825, Q62110, Q62111, Q62112, Q62113, Q62114, Q62115, Q62116, Q62564	Gene names	Slc34a1, Npt2, Slc17a2
Domain Architecture
Description	Sodium-dependent phosphate transport protein 2A (Sodium/phosphate cotransporter 2A) (Na(+)/Pi cotransporter 2A) (Sodium-phosphate transport protein 2A) (Na(+)-dependent phosphate cotransporter 2A) (NaPi-2a) (Solute carrier family 34 member 1) (NaPi-7).

NFM_HUMAN
NC score	0.021049 (rank : 12)	θ value	0.21417 (rank : 5)
Query Neighborhood Hits	30	Target Neighborhood Hits	1328	Shared Neighborhood Hits	11
SwissProt Accessions	P07197	Gene names	NEF3, NEFM, NFM
Domain Architecture
Description	Neurofilament triplet M protein (160 kDa neurofilament protein) (Neurofilament medium polypeptide) (NF-M) (Neurofilament 3).

DJC12_HUMAN
NC score	0.019274 (rank : 13)	θ value	4.03905 (rank : 16)
Query Neighborhood Hits	30	Target Neighborhood Hits	141	Shared Neighborhood Hits	2
SwissProt Accessions	Q9UKB3, Q9UKB2	Gene names	DNAJC12, JDP1
Domain Architecture
Description	DnaJ homolog subfamily C member 12 (J domain-containing protein 1).

SKIL_HUMAN
NC score	0.018500 (rank : 14)	θ value	5.27518 (rank : 23)
Query Neighborhood Hits	30	Target Neighborhood Hits	460	Shared Neighborhood Hits	8
SwissProt Accessions	P12757, O00464, P12756, Q07501	Gene names	SKIL, SNO
Domain Architecture
Description	Ski-like protein (Ski-related protein) (Ski-related oncogene).

MYH9_MOUSE
NC score	0.017290 (rank : 15)	θ value	0.21417 (rank : 4)
Query Neighborhood Hits	30	Target Neighborhood Hits	1829	Shared Neighborhood Hits	11
SwissProt Accessions	Q8VDD5	Gene names	Myh9
Domain Architecture	No domain graphic available
Description	Myosin-9 (Myosin heavy chain, nonmuscle IIa) (Nonmuscle myosin heavy chain IIa) (NMMHC II-a) (NMMHC-IIA) (Cellular myosin heavy chain, type A) (Nonmuscle myosin heavy chain-A) (NMMHC-A).

SYMPK_HUMAN
NC score	0.015868 (rank : 16)	θ value	6.88961 (rank : 26)
Query Neighborhood Hits	30	Target Neighborhood Hits	90	Shared Neighborhood Hits	2
SwissProt Accessions	Q92797, O00521, O00689, O00733, Q59GT5, Q8N2U5	Gene names	SYMPK, SPK
Domain Architecture	No domain graphic available
Description	Symplekin.

TXND2_HUMAN
NC score	0.015135 (rank : 17)	θ value	5.27518 (rank : 24)
Query Neighborhood Hits	30	Target Neighborhood Hits	793	Shared Neighborhood Hits	5
SwissProt Accessions	Q86VQ3, Q8N7U4, Q96RX3, Q9H0L8	Gene names	TXNDC2, SPTRX, SPTRX1
Domain Architecture	No domain graphic available
Description	Thioredoxin domain-containing protein 2 (Spermatid-specific thioredoxin-1) (Sptrx-1).

NEBU_HUMAN
NC score	0.014143 (rank : 18)	θ value	5.27518 (rank : 20)
Query Neighborhood Hits	30	Target Neighborhood Hits	420	Shared Neighborhood Hits	3
SwissProt Accessions	P20929, Q15346	Gene names	NEB
Domain Architecture
Description	Nebulin.

K1718_HUMAN
NC score	0.013626 (rank : 19)	θ value	4.03905 (rank : 17)
Query Neighborhood Hits	30	Target Neighborhood Hits	114	Shared Neighborhood Hits	3
SwissProt Accessions	Q6ZMT4, Q6MZL8, Q9C0E5	Gene names	KIAA1718
Domain Architecture	No domain graphic available
Description	Protein KIAA1718.

MYH9_HUMAN
NC score	0.012595 (rank : 20)	θ value	4.03905 (rank : 18)
Query Neighborhood Hits	30	Target Neighborhood Hits	1762	Shared Neighborhood Hits	11
SwissProt Accessions	P35579, O60805	Gene names	MYH9
Domain Architecture
Description	Myosin-9 (Myosin heavy chain, nonmuscle IIa) (Nonmuscle myosin heavy chain IIa) (NMMHC II-a) (NMMHC-IIA) (Cellular myosin heavy chain, type A) (Nonmuscle myosin heavy chain-A) (NMMHC-A).

CD7_HUMAN
NC score	0.011377 (rank : 21)	θ value	8.99809 (rank : 27)
Query Neighborhood Hits	30	Target Neighborhood Hits	190	Shared Neighborhood Hits	2
SwissProt Accessions	P09564	Gene names	CD7
Domain Architecture
Description	T-cell antigen CD7 precursor (GP40) (T-cell leukemia antigen) (TP41) (Leu-9).

ITSN1_MOUSE
NC score	0.011087 (rank : 22)	θ value	2.36792 (rank : 11)
Query Neighborhood Hits	30	Target Neighborhood Hits	1669	Shared Neighborhood Hits	9
SwissProt Accessions	Q9Z0R4, Q9R143	Gene names	Itsn1, Ese1, Itsn
Domain Architecture
Description	Intersectin-1 (EH and SH3 domains protein 1).

DESP_HUMAN
NC score	0.009449 (rank : 23)	θ value	8.99809 (rank : 28)
Query Neighborhood Hits	30	Target Neighborhood Hits	1470	Shared Neighborhood Hits	9
SwissProt Accessions	P15924, O75993, Q14189, Q9UHN4	Gene names	DSP
Domain Architecture
Description	Desmoplakin (DP) (250/210 kDa paraneoplastic pemphigus antigen).

FAK2_MOUSE
NC score	0.008758 (rank : 24)	θ value	3.0926 (rank : 14)
Query Neighborhood Hits	30	Target Neighborhood Hits	851	Shared Neighborhood Hits	7
SwissProt Accessions	Q9QVP9	Gene names	Ptk2b, Fak2, Pyk2, Raftk
Domain Architecture	No domain graphic available
Description	Protein tyrosine kinase 2 beta (EC 2.7.10.2) (Focal adhesion kinase 2) (FADK 2) (Proline-rich tyrosine kinase 2) (Cell adhesion kinase beta) (CAK beta) (Calcium-dependent tyrosine kinase) (CADTK) (Related adhesion focal tyrosine kinase) (RAFTK).

FAK2_HUMAN
NC score	0.008712 (rank : 25)	θ value	3.0926 (rank : 13)
Query Neighborhood Hits	30	Target Neighborhood Hits	847	Shared Neighborhood Hits	6
SwissProt Accessions	Q14289, Q13475, Q14290, Q16709	Gene names	PTK2B, FAK2, PYK2, RAFTK
Domain Architecture
Description	Protein tyrosine kinase 2 beta (EC 2.7.10.2) (Focal adhesion kinase 2) (FADK 2) (Proline-rich tyrosine kinase 2) (Cell adhesion kinase beta) (CAK beta) (Calcium-dependent tyrosine kinase) (CADTK) (Related adhesion focal tyrosine kinase) (RAFTK).

NOTC1_MOUSE
NC score	0.007314 (rank : 26)	θ value	6.88961 (rank : 25)
Query Neighborhood Hits	30	Target Neighborhood Hits	916	Shared Neighborhood Hits	4
SwissProt Accessions	Q01705, Q06007, Q61905, Q99JC2, Q9QW58, Q9R0X7	Gene names	Notch1, Motch
Domain Architecture
Description	Neurogenic locus notch homolog protein 1 precursor (Notch 1) (Motch A) (mT14) (p300) [Contains: Notch 1 extracellular truncation; Notch 1 intracellular domain].

ANPRA_HUMAN
NC score	0.007040 (rank : 27)	θ value	4.03905 (rank : 15)
Query Neighborhood Hits	30	Target Neighborhood Hits	612	Shared Neighborhood Hits	5
SwissProt Accessions	P16066, Q6P4Q3	Gene names	NPR1, ANPRA
Domain Architecture
Description	Atrial natriuretic peptide receptor A precursor (ANP-A) (ANPRA) (GC-A) (Guanylate cyclase) (EC 4.6.1.2) (NPR-A) (Atrial natriuretic peptide A-type receptor).

NMDE1_MOUSE
NC score	0.005376 (rank : 28)	θ value	8.99809 (rank : 29)
Query Neighborhood Hits	30	Target Neighborhood Hits	84	Shared Neighborhood Hits	2
SwissProt Accessions	P35436	Gene names	Grin2a
Domain Architecture	No domain graphic available
Description	Glutamate [NMDA] receptor subunit epsilon 1 precursor (N-methyl D- aspartate receptor subtype 2A) (NR2A) (NMDAR2A).

NOTC1_HUMAN
NC score	0.003801 (rank : 29)	θ value	8.99809 (rank : 30)
Query Neighborhood Hits	30	Target Neighborhood Hits	906	Shared Neighborhood Hits	3
SwissProt Accessions	P46531	Gene names	NOTCH1, TAN1
Domain Architecture
Description	Neurogenic locus notch homolog protein 1 precursor (Notch 1) (hN1) (Translocation-associated notch protein TAN-1) [Contains: Notch 1 extracellular truncation; Notch 1 intracellular domain].

M4K2_HUMAN
NC score	0.002718 (rank : 30)	θ value	5.27518 (rank : 19)
Query Neighborhood Hits	30	Target Neighborhood Hits	850	Shared Neighborhood Hits	5
SwissProt Accessions	Q12851	Gene names	MAP4K2, GCK, RAB8IP
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase kinase 2 (EC 2.7.11.1) (MAPK/ERK kinase kinase kinase 2) (MEK kinase kinase 2) (MEKKK 2) (Germinal center kinase) (GC kinase) (Rab8-interacting protein) (B lymphocyte serine/threonine-protein kinase).