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Network neighborhood for query Sequence : ECHM_HUMAN

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ECHM_HUMAN
SwissProt Accessions	P30084, O00739, Q5VWY1, Q96H54	Gene names	ECHS1
Domain Architecture
Description	Enoyl-CoA hydratase, mitochondrial precursor (EC 4.2.1.17) (Short chain enoyl-CoA hydratase) (SCEH) (Enoyl-CoA hydratase 1).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

ECHM_HUMAN
θ value	5.74867e-164 (rank : 1)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	23	Target Neighborhood Hits	23	Shared Neighborhood Hits	23
SwissProt Accessions	P30084, O00739, Q5VWY1, Q96H54	Gene names	ECHS1
Domain Architecture
Description	Enoyl-CoA hydratase, mitochondrial precursor (EC 4.2.1.17) (Short chain enoyl-CoA hydratase) (SCEH) (Enoyl-CoA hydratase 1).

ECHM_MOUSE
θ value	2.35023e-141 (rank : 2)	NC score	0.998399 (rank : 2)
Query Neighborhood Hits	23	Target Neighborhood Hits	18	Shared Neighborhood Hits	18
SwissProt Accessions	Q8BH95, Q3TJK2, Q6GQS2, Q6PEN1, Q99LX7	Gene names	Echs1
Domain Architecture	No domain graphic available
Description	Enoyl-CoA hydratase, mitochondrial precursor (EC 4.2.1.17) (Short chain enoyl-CoA hydratase) (SCEH) (Enoyl-CoA hydratase 1).

AUHM_MOUSE
θ value	6.17384e-33 (rank : 3)	NC score	0.898267 (rank : 3)
Query Neighborhood Hits	23	Target Neighborhood Hits	19	Shared Neighborhood Hits	18
SwissProt Accessions	Q9JLZ3, Q80YD7, Q8QZS0, Q9CY78, Q9D155	Gene names	Auh
Domain Architecture
Description	Methylglutaconyl-CoA hydratase, mitochondrial precursor (EC 4.2.1.18) (AU-specific RNA-binding enoyl-CoA hydratase) (AU-binding enoyl-CoA hydratase) (muAUH).

AUMH_HUMAN
θ value	1.0531e-32 (rank : 4)	NC score	0.892919 (rank : 4)
Query Neighborhood Hits	23	Target Neighborhood Hits	21	Shared Neighborhood Hits	18
SwissProt Accessions	Q13825, Q8WUE4	Gene names	AUH
Domain Architecture
Description	Methylglutaconyl-CoA hydratase, mitochondrial precursor (EC 4.2.1.18) (AU-specific RNA-binding enoyl-CoA hydratase) (AU-binding protein/enoyl-CoA hydratase).

ECHP_HUMAN
θ value	2.12685e-25 (rank : 5)	NC score	0.718707 (rank : 8)
Query Neighborhood Hits	23	Target Neighborhood Hits	28	Shared Neighborhood Hits	16
SwissProt Accessions	Q08426	Gene names	EHHADH, ECHD
Domain Architecture
Description	Peroxisomal bifunctional enzyme (PBE) (PBFE) [Includes: Enoyl-CoA hydratase (EC 4.2.1.17); 3,2-trans-enoyl-CoA isomerase (EC 5.3.3.8); 3-hydroxyacyl-CoA dehydrogenase (EC 1.1.1.35)].

ECHP_MOUSE
θ value	2.20094e-22 (rank : 6)	NC score	0.712991 (rank : 9)
Query Neighborhood Hits	23	Target Neighborhood Hits	26	Shared Neighborhood Hits	17
SwissProt Accessions	Q9DBM2	Gene names	Ehhadh
Domain Architecture
Description	Peroxisomal bifunctional enzyme (PBE) (PBFE) [Includes: Enoyl-CoA hydratase (EC 4.2.1.17); 3,2-trans-enoyl-CoA isomerase (EC 5.3.3.8); 3-hydroxyacyl-CoA dehydrogenase (EC 1.1.1.35)].

ECH1_HUMAN
θ value	4.15078e-21 (rank : 7)	NC score	0.842196 (rank : 5)
Query Neighborhood Hits	23	Target Neighborhood Hits	18	Shared Neighborhood Hits	18
SwissProt Accessions	Q13011, Q8WVX0, Q96EZ9	Gene names	ECH1
Domain Architecture
Description	Delta3,5-delta2,4-dienoyl-CoA isomerase, mitochondrial precursor (EC 5.3.3.-).

ECHA_HUMAN
θ value	4.58923e-20 (rank : 8)	NC score	0.738782 (rank : 7)
Query Neighborhood Hits	23	Target Neighborhood Hits	28	Shared Neighborhood Hits	18
SwissProt Accessions	P40939, Q16679, Q96GT7	Gene names	HADHA, HADH
Domain Architecture
Description	Trifunctional enzyme subunit alpha, mitochondrial precursor (TP-alpha) (78 kDa gastrin-binding protein) [Includes: Long-chain enoyl-CoA hydratase (EC 4.2.1.17); Long chain 3-hydroxyacyl-CoA dehydrogenase (EC 1.1.1.211)].

ECH1_MOUSE
θ value	5.99374e-20 (rank : 9)	NC score	0.825784 (rank : 6)
Query Neighborhood Hits	23	Target Neighborhood Hits	19	Shared Neighborhood Hits	18
SwissProt Accessions	O35459, Q5M8P6	Gene names	Ech1
Domain Architecture
Description	Delta3,5-delta2,4-dienoyl-CoA isomerase, mitochondrial precursor (EC 5.3.3.-).

CDY1_HUMAN
θ value	9.56915e-18 (rank : 10)	NC score	0.673831 (rank : 10)
Query Neighborhood Hits	23	Target Neighborhood Hits	48	Shared Neighborhood Hits	16
SwissProt Accessions	Q9Y6F8, O14600	Gene names	CDY1
Domain Architecture
Description	Testis-specific chromodomain protein Y 1.

CDY2_HUMAN
θ value	3.63628e-17 (rank : 11)	NC score	0.670177 (rank : 12)
Query Neighborhood Hits	23	Target Neighborhood Hits	49	Shared Neighborhood Hits	16
SwissProt Accessions	Q9Y6F7	Gene names	CDY2A, CDY2
Domain Architecture
Description	Testis-specific chromodomain protein Y 2.

CDYL1_HUMAN
θ value	3.63628e-17 (rank : 12)	NC score	0.664719 (rank : 15)
Query Neighborhood Hits	23	Target Neighborhood Hits	92	Shared Neighborhood Hits	16
SwissProt Accessions	Q9Y232	Gene names	CDYL, CDYL1
Domain Architecture
Description	Chromodomain Y-like protein (CDY-like).

CDYL_MOUSE
θ value	8.10077e-17 (rank : 13)	NC score	0.671605 (rank : 11)
Query Neighborhood Hits	23	Target Neighborhood Hits	69	Shared Neighborhood Hits	16
SwissProt Accessions	Q9WTK2	Gene names	Cdyl
Domain Architecture
Description	Chromodomain Y-like protein (CDY-like).

CDYL2_HUMAN
θ value	3.07829e-16 (rank : 14)	NC score	0.668538 (rank : 13)
Query Neighborhood Hits	23	Target Neighborhood Hits	53	Shared Neighborhood Hits	15
SwissProt Accessions	Q8N8U2	Gene names	CDYL2
Domain Architecture
Description	Chromodomain Y-like protein 2 (CDY-like 2).

PECI_HUMAN
θ value	6.00763e-12 (rank : 15)	NC score	0.617788 (rank : 16)
Query Neighborhood Hits	23	Target Neighborhood Hits	26	Shared Neighborhood Hits	16
SwissProt Accessions	O75521, Q5JYK5, Q8N0X0, Q9BUE9, Q9H0T9, Q9NQH1, Q9NYH7, Q9UN55	Gene names	PECI, DRS1, HCA88
Domain Architecture
Description	Peroxisomal 3,2-trans-enoyl-CoA isomerase (EC 5.3.3.8) (Dodecenoyl-CoA isomerase) (Delta(3),delta(2)-enoyl-CoA isomerase) (D3,D2-enoyl-CoA isomerase) (DBI-related protein 1) (DRS-1) (Hepatocellular carcinoma- associated antigen 88) (NY-REN-1 antigen).

PECI_MOUSE
θ value	1.74796e-11 (rank : 16)	NC score	0.665503 (rank : 14)
Query Neighborhood Hits	23	Target Neighborhood Hits	28	Shared Neighborhood Hits	18
SwissProt Accessions	Q9WUR2	Gene names	Peci
Domain Architecture
Description	Peroxisomal 3,2-trans-enoyl-CoA isomerase (EC 5.3.3.8) (Dodecenoyl-CoA isomerase) (Delta(3),delta(2)-enoyl-CoA isomerase) (D3,D2-enoyl-CoA isomerase).

D3D2_MOUSE
θ value	8.11959e-09 (rank : 17)	NC score	0.568168 (rank : 18)
Query Neighborhood Hits	23	Target Neighborhood Hits	14	Shared Neighborhood Hits	13
SwissProt Accessions	P42125	Gene names	Dci
Domain Architecture
Description	3,2-trans-enoyl-CoA isomerase, mitochondrial precursor (EC 5.3.3.8) (Dodecenoyl-CoA isomerase) (Delta(3),delta(2)-enoyl-CoA isomerase) (D3,D2-enoyl-CoA isomerase).

D3D2_HUMAN
θ value	1.53129e-07 (rank : 18)	NC score	0.578544 (rank : 17)
Query Neighborhood Hits	23	Target Neighborhood Hits	15	Shared Neighborhood Hits	13
SwissProt Accessions	P42126, Q13290, Q7Z2L6, Q9BUB8, Q9BW05	Gene names	DCI
Domain Architecture
Description	3,2-trans-enoyl-CoA isomerase, mitochondrial precursor (EC 5.3.3.8) (Dodecenoyl-CoA isomerase) (Delta(3),delta(2)-enoyl-CoA isomerase) (D3,D2-enoyl-CoA isomerase).

COPD_HUMAN
θ value	1.81305 (rank : 19)	NC score	0.040627 (rank : 46)
Query Neighborhood Hits	23	Target Neighborhood Hits	40	Shared Neighborhood Hits	3
SwissProt Accessions	P48444, Q52M80	Gene names	ARCN1, COPD
Domain Architecture
Description	Coatomer subunit delta (Delta-coat protein) (Delta-COP) (Archain).

COPD_MOUSE
θ value	1.81305 (rank : 20)	NC score	0.040630 (rank : 45)
Query Neighborhood Hits	23	Target Neighborhood Hits	41	Shared Neighborhood Hits	3
SwissProt Accessions	Q5XJY5	Gene names	Arcn1, Copd
Domain Architecture	No domain graphic available
Description	Coatomer subunit delta (Delta-coat protein) (Delta-COP) (Archain).

NOVA2_HUMAN
θ value	6.88961 (rank : 21)	NC score	0.010357 (rank : 47)
Query Neighborhood Hits	23	Target Neighborhood Hits	51	Shared Neighborhood Hits	2
SwissProt Accessions	Q9UNW9, O43267, Q9UEA1	Gene names	NOVA2, ANOVA, NOVA3
Domain Architecture
Description	RNA-binding protein Nova-2 (Neuro-oncological ventral antigen 2) (Astrocytic NOVA1-like RNA-binding protein).

EPIPL_HUMAN
θ value	8.99809 (rank : 22)	NC score	0.007434 (rank : 48)
Query Neighborhood Hits	23	Target Neighborhood Hits	73	Shared Neighborhood Hits	2
SwissProt Accessions	P58107, Q76E58	Gene names	EPPK1, EPIPL
Domain Architecture
Description	Epiplakin (450 kDa epidermal antigen).

PLVAP_HUMAN
θ value	8.99809 (rank : 23)	NC score	0.006718 (rank : 49)
Query Neighborhood Hits	23	Target Neighborhood Hits	397	Shared Neighborhood Hits	2
SwissProt Accessions	Q9BX97, Q86VP0, Q8N8Y0, Q8ND68, Q8TER8, Q9BZD5	Gene names	PLVAP, FELS, PV1
Domain Architecture	No domain graphic available
Description	Plasmalemma vesicle-associated protein (Plasmalemma vesicle protein 1) (PV-1) (Fenestrated endothelial-linked structure protein).

ACBD4_HUMAN
θ value	θ > 10 (rank : 24)	NC score	0.070086 (rank : 37)
Query Neighborhood Hits	23	Target Neighborhood Hits	17	Shared Neighborhood Hits	2
SwissProt Accessions	Q8NC06, Q8IUT1, Q9H8Q4	Gene names	ACBD4
Domain Architecture	No domain graphic available
Description	Acyl-CoA-binding domain-containing protein 4.

ACBD7_HUMAN
θ value	θ > 10 (rank : 25)	NC score	0.073461 (rank : 34)
Query Neighborhood Hits	23	Target Neighborhood Hits	9	Shared Neighborhood Hits	2
SwissProt Accessions	Q8N6N7	Gene names	ACBD7
Domain Architecture	No domain graphic available
Description	Acyl-CoA-binding domain-containing protein 7.

ACBP_HUMAN
θ value	θ > 10 (rank : 26)	NC score	0.076942 (rank : 31)
Query Neighborhood Hits	23	Target Neighborhood Hits	12	Shared Neighborhood Hits	2
SwissProt Accessions	P07108, P08869, Q53SQ7, Q6IB48	Gene names	DBI
Domain Architecture
Description	Acyl-CoA-binding protein (ACBP) (Diazepam-binding inhibitor) (DBI) (Endozepine) (EP).

ACBP_MOUSE
θ value	θ > 10 (rank : 27)	NC score	0.078117 (rank : 30)
Query Neighborhood Hits	23	Target Neighborhood Hits	10	Shared Neighborhood Hits	2
SwissProt Accessions	P31786	Gene names	Dbi
Domain Architecture
Description	Acyl-CoA-binding protein (ACBP) (Diazepam-binding inhibitor) (DBI) (Endozepine) (EP).

CBX1_HUMAN
θ value	θ > 10 (rank : 28)	NC score	0.096034 (rank : 25)
Query Neighborhood Hits	23	Target Neighborhood Hits	44	Shared Neighborhood Hits	5
SwissProt Accessions	P83916, P23197	Gene names	CBX1, CBX
Domain Architecture
Description	Chromobox protein homolog 1 (Heterochromatin protein 1 homolog beta) (HP1 beta) (Modifier 1 protein) (M31) (Heterochromatin protein p25) (HP1Hsbeta) (p25beta).

CBX1_MOUSE
θ value	θ > 10 (rank : 29)	NC score	0.096034 (rank : 26)
Query Neighborhood Hits	23	Target Neighborhood Hits	44	Shared Neighborhood Hits	5
SwissProt Accessions	P83917, P23197	Gene names	Cbx1, Cbx
Domain Architecture
Description	Chromobox protein homolog 1 (Heterochromatin protein 1 homolog beta) (HP1 beta) (Modifier 1 protein) (M31) (Heterochromatin protein p25).

CBX2_HUMAN
θ value	θ > 10 (rank : 30)	NC score	0.066070 (rank : 43)
Query Neighborhood Hits	23	Target Neighborhood Hits	264	Shared Neighborhood Hits	5
SwissProt Accessions	Q14781, Q9BTB1	Gene names	CBX2
Domain Architecture	No domain graphic available
Description	Chromobox protein homolog 2.

CBX2_MOUSE
θ value	θ > 10 (rank : 31)	NC score	0.074006 (rank : 32)
Query Neighborhood Hits	23	Target Neighborhood Hits	119	Shared Neighborhood Hits	5
SwissProt Accessions	P30658, O35731, Q8CIA0	Gene names	Cbx2, M33
Domain Architecture
Description	Chromobox protein homolog 2 (Modifier 3 protein) (M33).

CBX3_HUMAN
θ value	θ > 10 (rank : 32)	NC score	0.096369 (rank : 24)
Query Neighborhood Hits	23	Target Neighborhood Hits	36	Shared Neighborhood Hits	5
SwissProt Accessions	Q13185, Q96CD7, Q99409, Q9BVS3, Q9P0Z6	Gene names	CBX3
Domain Architecture
Description	Chromobox protein homolog 3 (Heterochromatin protein 1 homolog gamma) (HP1 gamma) (Modifier 2 protein) (HECH).

CBX3_MOUSE
θ value	θ > 10 (rank : 33)	NC score	0.103622 (rank : 22)
Query Neighborhood Hits	23	Target Neighborhood Hits	39	Shared Neighborhood Hits	5
SwissProt Accessions	P23198, Q921C4	Gene names	Cbx3
Domain Architecture
Description	Chromobox protein homolog 3 (Heterochromatin protein 1 homolog gamma) (HP1 gamma) (Modifier 2 protein) (M32).

CBX4_HUMAN
θ value	θ > 10 (rank : 34)	NC score	0.066493 (rank : 42)
Query Neighborhood Hits	23	Target Neighborhood Hits	68	Shared Neighborhood Hits	5
SwissProt Accessions	O00257, Q96C04	Gene names	CBX4
Domain Architecture
Description	Chromobox protein homolog 4 (Polycomb 2 homolog) (Pc2) (hPc2).

CBX4_MOUSE
θ value	θ > 10 (rank : 35)	NC score	0.066841 (rank : 41)
Query Neighborhood Hits	23	Target Neighborhood Hits	64	Shared Neighborhood Hits	5
SwissProt Accessions	O55187	Gene names	Cbx4, Pc2
Domain Architecture
Description	Chromobox protein homolog 4 (Polycomb 2 homolog) (Pc2) (mPc2).

CBX5_HUMAN
θ value	θ > 10 (rank : 36)	NC score	0.096011 (rank : 27)
Query Neighborhood Hits	23	Target Neighborhood Hits	70	Shared Neighborhood Hits	5
SwissProt Accessions	P45973	Gene names	CBX5, HP1A
Domain Architecture
Description	Chromobox protein homolog 5 (Heterochromatin protein 1 homolog alpha) (HP1 alpha) (Antigen p25).

CBX5_MOUSE
θ value	θ > 10 (rank : 37)	NC score	0.097324 (rank : 23)
Query Neighborhood Hits	23	Target Neighborhood Hits	67	Shared Neighborhood Hits	5
SwissProt Accessions	Q61686, Q9CS35, Q9CXD1	Gene names	Cbx5, Hp1a
Domain Architecture
Description	Chromobox protein homolog 5 (Heterochromatin protein 1 homolog alpha) (HP1 alpha).

CBX6_HUMAN
θ value	θ > 10 (rank : 38)	NC score	0.068505 (rank : 40)
Query Neighborhood Hits	23	Target Neighborhood Hits	104	Shared Neighborhood Hits	5
SwissProt Accessions	O95503, Q96EM5	Gene names	CBX6
Domain Architecture
Description	Chromobox protein homolog 6.

CBX6_MOUSE
θ value	θ > 10 (rank : 39)	NC score	0.069138 (rank : 39)
Query Neighborhood Hits	23	Target Neighborhood Hits	50	Shared Neighborhood Hits	5
SwissProt Accessions	Q9DBY5, Q8BZH5	Gene names	Cbx6
Domain Architecture
Description	Chromobox protein homolog 6.

CBX7_HUMAN
θ value	θ > 10 (rank : 40)	NC score	0.081864 (rank : 29)
Query Neighborhood Hits	23	Target Neighborhood Hits	48	Shared Neighborhood Hits	5
SwissProt Accessions	O95931, Q86T17	Gene names	CBX7
Domain Architecture
Description	Chromobox protein homolog 7.

CBX7_MOUSE
θ value	θ > 10 (rank : 41)	NC score	0.088274 (rank : 28)
Query Neighborhood Hits	23	Target Neighborhood Hits	38	Shared Neighborhood Hits	5
SwissProt Accessions	Q8VDS3	Gene names	Cbx7, D15Ertd417e
Domain Architecture
Description	Chromobox protein homolog 7.

CBX8_HUMAN
θ value	θ > 10 (rank : 42)	NC score	0.069541 (rank : 38)
Query Neighborhood Hits	23	Target Neighborhood Hits	67	Shared Neighborhood Hits	5
SwissProt Accessions	Q9HC52, Q96H39, Q9NR07	Gene names	CBX8, PC3, RC1
Domain Architecture
Description	Chromobox protein homolog 8 (Polycomb 3 homolog) (Pc3) (hPc3) (Rectachrome 1).

CBX8_MOUSE
θ value	θ > 10 (rank : 43)	NC score	0.070443 (rank : 36)
Query Neighborhood Hits	23	Target Neighborhood Hits	46	Shared Neighborhood Hits	5
SwissProt Accessions	Q9QXV1	Gene names	Cbx8, Pc3
Domain Architecture
Description	Chromobox protein homolog 8 (Polycomb 3 homolog) (Pc3) (mPc3).

CRYL1_HUMAN
θ value	θ > 10 (rank : 44)	NC score	0.111512 (rank : 21)
Query Neighborhood Hits	23	Target Neighborhood Hits	12	Shared Neighborhood Hits	3
SwissProt Accessions	Q9Y2S2, Q7Z4Z9	Gene names	CRYL1, CRY
Domain Architecture
Description	Lambda-crystallin homolog.

CRYL1_MOUSE
θ value	θ > 10 (rank : 45)	NC score	0.073627 (rank : 33)
Query Neighborhood Hits	23	Target Neighborhood Hits	12	Shared Neighborhood Hits	2
SwissProt Accessions	Q99KP3, Q542R9, Q8R4W7	Gene names	Cryl1, Cry
Domain Architecture
Description	Lambda-crystallin homolog.

DBIL5_MOUSE
θ value	θ > 10 (rank : 46)	NC score	0.071924 (rank : 35)
Query Neighborhood Hits	23	Target Neighborhood Hits	9	Shared Neighborhood Hits	2
SwissProt Accessions	O09035	Gene names	Dbil5
Domain Architecture
Description	Diazepam-binding inhibitor-like 5 (Endozepine-like peptide) (ELP).

HCDH_HUMAN
θ value	θ > 10 (rank : 47)	NC score	0.188848 (rank : 19)
Query Neighborhood Hits	23	Target Neighborhood Hits	13	Shared Neighborhood Hits	3
SwissProt Accessions	Q16836, O00324, O00397, O00753	Gene names	HADHSC, HAD, SCHAD
Domain Architecture
Description	Short chain 3-hydroxyacyl-CoA dehydrogenase, mitochondrial precursor (EC 1.1.1.35) (HCDH) (Medium and short chain L-3-hydroxyacyl-coenzyme A dehydrogenase).

HCDH_MOUSE
θ value	θ > 10 (rank : 48)	NC score	0.185763 (rank : 20)
Query Neighborhood Hits	23	Target Neighborhood Hits	13	Shared Neighborhood Hits	3
SwissProt Accessions	Q61425, Q3TF75, Q3THK8, Q3UFI0, Q8K149, Q925U9	Gene names	Hadhsc, Hadh, Mschad, Schad
Domain Architecture
Description	Short chain 3-hydroxyacyl-CoA dehydrogenase, mitochondrial precursor (EC 1.1.1.35) (HCDH) (Medium and short chain L-3-hydroxyacyl-coenzyme A dehydrogenase).

MPP8_HUMAN
θ value	θ > 10 (rank : 49)	NC score	0.056332 (rank : 44)
Query Neighborhood Hits	23	Target Neighborhood Hits	948	Shared Neighborhood Hits	5
SwissProt Accessions	Q99549, Q86TK3, Q9BTP1	Gene names	MPHOSPH8, MPP8
Domain Architecture	No domain graphic available
Description	M-phase phosphoprotein 8.

Hits sorted by NC score

ECHM_HUMAN
NC score	0.999962 (rank : 1)	θ value	5.74867e-164 (rank : 1)
Query Neighborhood Hits	23	Target Neighborhood Hits	23	Shared Neighborhood Hits	23
SwissProt Accessions	P30084, O00739, Q5VWY1, Q96H54	Gene names	ECHS1
Domain Architecture
Description	Enoyl-CoA hydratase, mitochondrial precursor (EC 4.2.1.17) (Short chain enoyl-CoA hydratase) (SCEH) (Enoyl-CoA hydratase 1).

ECHM_MOUSE
NC score	0.998399 (rank : 2)	θ value	2.35023e-141 (rank : 2)
Query Neighborhood Hits	23	Target Neighborhood Hits	18	Shared Neighborhood Hits	18
SwissProt Accessions	Q8BH95, Q3TJK2, Q6GQS2, Q6PEN1, Q99LX7	Gene names	Echs1
Domain Architecture	No domain graphic available
Description	Enoyl-CoA hydratase, mitochondrial precursor (EC 4.2.1.17) (Short chain enoyl-CoA hydratase) (SCEH) (Enoyl-CoA hydratase 1).

AUHM_MOUSE
NC score	0.898267 (rank : 3)	θ value	6.17384e-33 (rank : 3)
Query Neighborhood Hits	23	Target Neighborhood Hits	19	Shared Neighborhood Hits	18
SwissProt Accessions	Q9JLZ3, Q80YD7, Q8QZS0, Q9CY78, Q9D155	Gene names	Auh
Domain Architecture
Description	Methylglutaconyl-CoA hydratase, mitochondrial precursor (EC 4.2.1.18) (AU-specific RNA-binding enoyl-CoA hydratase) (AU-binding enoyl-CoA hydratase) (muAUH).

AUMH_HUMAN
NC score	0.892919 (rank : 4)	θ value	1.0531e-32 (rank : 4)
Query Neighborhood Hits	23	Target Neighborhood Hits	21	Shared Neighborhood Hits	18
SwissProt Accessions	Q13825, Q8WUE4	Gene names	AUH
Domain Architecture
Description	Methylglutaconyl-CoA hydratase, mitochondrial precursor (EC 4.2.1.18) (AU-specific RNA-binding enoyl-CoA hydratase) (AU-binding protein/enoyl-CoA hydratase).

ECH1_HUMAN
NC score	0.842196 (rank : 5)	θ value	4.15078e-21 (rank : 7)
Query Neighborhood Hits	23	Target Neighborhood Hits	18	Shared Neighborhood Hits	18
SwissProt Accessions	Q13011, Q8WVX0, Q96EZ9	Gene names	ECH1
Domain Architecture
Description	Delta3,5-delta2,4-dienoyl-CoA isomerase, mitochondrial precursor (EC 5.3.3.-).

ECH1_MOUSE
NC score	0.825784 (rank : 6)	θ value	5.99374e-20 (rank : 9)
Query Neighborhood Hits	23	Target Neighborhood Hits	19	Shared Neighborhood Hits	18
SwissProt Accessions	O35459, Q5M8P6	Gene names	Ech1
Domain Architecture
Description	Delta3,5-delta2,4-dienoyl-CoA isomerase, mitochondrial precursor (EC 5.3.3.-).

ECHA_HUMAN
NC score	0.738782 (rank : 7)	θ value	4.58923e-20 (rank : 8)
Query Neighborhood Hits	23	Target Neighborhood Hits	28	Shared Neighborhood Hits	18
SwissProt Accessions	P40939, Q16679, Q96GT7	Gene names	HADHA, HADH
Domain Architecture
Description	Trifunctional enzyme subunit alpha, mitochondrial precursor (TP-alpha) (78 kDa gastrin-binding protein) [Includes: Long-chain enoyl-CoA hydratase (EC 4.2.1.17); Long chain 3-hydroxyacyl-CoA dehydrogenase (EC 1.1.1.211)].

ECHP_HUMAN
NC score	0.718707 (rank : 8)	θ value	2.12685e-25 (rank : 5)
Query Neighborhood Hits	23	Target Neighborhood Hits	28	Shared Neighborhood Hits	16
SwissProt Accessions	Q08426	Gene names	EHHADH, ECHD
Domain Architecture
Description	Peroxisomal bifunctional enzyme (PBE) (PBFE) [Includes: Enoyl-CoA hydratase (EC 4.2.1.17); 3,2-trans-enoyl-CoA isomerase (EC 5.3.3.8); 3-hydroxyacyl-CoA dehydrogenase (EC 1.1.1.35)].

ECHP_MOUSE
NC score	0.712991 (rank : 9)	θ value	2.20094e-22 (rank : 6)
Query Neighborhood Hits	23	Target Neighborhood Hits	26	Shared Neighborhood Hits	17
SwissProt Accessions	Q9DBM2	Gene names	Ehhadh
Domain Architecture
Description	Peroxisomal bifunctional enzyme (PBE) (PBFE) [Includes: Enoyl-CoA hydratase (EC 4.2.1.17); 3,2-trans-enoyl-CoA isomerase (EC 5.3.3.8); 3-hydroxyacyl-CoA dehydrogenase (EC 1.1.1.35)].

CDY1_HUMAN
NC score	0.673831 (rank : 10)	θ value	9.56915e-18 (rank : 10)
Query Neighborhood Hits	23	Target Neighborhood Hits	48	Shared Neighborhood Hits	16
SwissProt Accessions	Q9Y6F8, O14600	Gene names	CDY1
Domain Architecture
Description	Testis-specific chromodomain protein Y 1.

CDYL_MOUSE
NC score	0.671605 (rank : 11)	θ value	8.10077e-17 (rank : 13)
Query Neighborhood Hits	23	Target Neighborhood Hits	69	Shared Neighborhood Hits	16
SwissProt Accessions	Q9WTK2	Gene names	Cdyl
Domain Architecture
Description	Chromodomain Y-like protein (CDY-like).

CDY2_HUMAN
NC score	0.670177 (rank : 12)	θ value	3.63628e-17 (rank : 11)
Query Neighborhood Hits	23	Target Neighborhood Hits	49	Shared Neighborhood Hits	16
SwissProt Accessions	Q9Y6F7	Gene names	CDY2A, CDY2
Domain Architecture
Description	Testis-specific chromodomain protein Y 2.

CDYL2_HUMAN
NC score	0.668538 (rank : 13)	θ value	3.07829e-16 (rank : 14)
Query Neighborhood Hits	23	Target Neighborhood Hits	53	Shared Neighborhood Hits	15
SwissProt Accessions	Q8N8U2	Gene names	CDYL2
Domain Architecture
Description	Chromodomain Y-like protein 2 (CDY-like 2).

PECI_MOUSE
NC score	0.665503 (rank : 14)	θ value	1.74796e-11 (rank : 16)
Query Neighborhood Hits	23	Target Neighborhood Hits	28	Shared Neighborhood Hits	18
SwissProt Accessions	Q9WUR2	Gene names	Peci
Domain Architecture
Description	Peroxisomal 3,2-trans-enoyl-CoA isomerase (EC 5.3.3.8) (Dodecenoyl-CoA isomerase) (Delta(3),delta(2)-enoyl-CoA isomerase) (D3,D2-enoyl-CoA isomerase).

CDYL1_HUMAN
NC score	0.664719 (rank : 15)	θ value	3.63628e-17 (rank : 12)
Query Neighborhood Hits	23	Target Neighborhood Hits	92	Shared Neighborhood Hits	16
SwissProt Accessions	Q9Y232	Gene names	CDYL, CDYL1
Domain Architecture
Description	Chromodomain Y-like protein (CDY-like).

PECI_HUMAN
NC score	0.617788 (rank : 16)	θ value	6.00763e-12 (rank : 15)
Query Neighborhood Hits	23	Target Neighborhood Hits	26	Shared Neighborhood Hits	16
SwissProt Accessions	O75521, Q5JYK5, Q8N0X0, Q9BUE9, Q9H0T9, Q9NQH1, Q9NYH7, Q9UN55	Gene names	PECI, DRS1, HCA88
Domain Architecture
Description	Peroxisomal 3,2-trans-enoyl-CoA isomerase (EC 5.3.3.8) (Dodecenoyl-CoA isomerase) (Delta(3),delta(2)-enoyl-CoA isomerase) (D3,D2-enoyl-CoA isomerase) (DBI-related protein 1) (DRS-1) (Hepatocellular carcinoma- associated antigen 88) (NY-REN-1 antigen).

D3D2_HUMAN
NC score	0.578544 (rank : 17)	θ value	1.53129e-07 (rank : 18)
Query Neighborhood Hits	23	Target Neighborhood Hits	15	Shared Neighborhood Hits	13
SwissProt Accessions	P42126, Q13290, Q7Z2L6, Q9BUB8, Q9BW05	Gene names	DCI
Domain Architecture
Description	3,2-trans-enoyl-CoA isomerase, mitochondrial precursor (EC 5.3.3.8) (Dodecenoyl-CoA isomerase) (Delta(3),delta(2)-enoyl-CoA isomerase) (D3,D2-enoyl-CoA isomerase).

D3D2_MOUSE
NC score	0.568168 (rank : 18)	θ value	8.11959e-09 (rank : 17)
Query Neighborhood Hits	23	Target Neighborhood Hits	14	Shared Neighborhood Hits	13
SwissProt Accessions	P42125	Gene names	Dci
Domain Architecture
Description	3,2-trans-enoyl-CoA isomerase, mitochondrial precursor (EC 5.3.3.8) (Dodecenoyl-CoA isomerase) (Delta(3),delta(2)-enoyl-CoA isomerase) (D3,D2-enoyl-CoA isomerase).

HCDH_HUMAN
NC score	0.188848 (rank : 19)	θ value	θ > 10 (rank : 47)
Query Neighborhood Hits	23	Target Neighborhood Hits	13	Shared Neighborhood Hits	3
SwissProt Accessions	Q16836, O00324, O00397, O00753	Gene names	HADHSC, HAD, SCHAD
Domain Architecture
Description	Short chain 3-hydroxyacyl-CoA dehydrogenase, mitochondrial precursor (EC 1.1.1.35) (HCDH) (Medium and short chain L-3-hydroxyacyl-coenzyme A dehydrogenase).

HCDH_MOUSE
NC score	0.185763 (rank : 20)	θ value	θ > 10 (rank : 48)
Query Neighborhood Hits	23	Target Neighborhood Hits	13	Shared Neighborhood Hits	3
SwissProt Accessions	Q61425, Q3TF75, Q3THK8, Q3UFI0, Q8K149, Q925U9	Gene names	Hadhsc, Hadh, Mschad, Schad
Domain Architecture
Description	Short chain 3-hydroxyacyl-CoA dehydrogenase, mitochondrial precursor (EC 1.1.1.35) (HCDH) (Medium and short chain L-3-hydroxyacyl-coenzyme A dehydrogenase).

CRYL1_HUMAN
NC score	0.111512 (rank : 21)	θ value	θ > 10 (rank : 44)
Query Neighborhood Hits	23	Target Neighborhood Hits	12	Shared Neighborhood Hits	3
SwissProt Accessions	Q9Y2S2, Q7Z4Z9	Gene names	CRYL1, CRY
Domain Architecture
Description	Lambda-crystallin homolog.

CBX3_MOUSE
NC score	0.103622 (rank : 22)	θ value	θ > 10 (rank : 33)
Query Neighborhood Hits	23	Target Neighborhood Hits	39	Shared Neighborhood Hits	5
SwissProt Accessions	P23198, Q921C4	Gene names	Cbx3
Domain Architecture
Description	Chromobox protein homolog 3 (Heterochromatin protein 1 homolog gamma) (HP1 gamma) (Modifier 2 protein) (M32).

CBX5_MOUSE
NC score	0.097324 (rank : 23)	θ value	θ > 10 (rank : 37)
Query Neighborhood Hits	23	Target Neighborhood Hits	67	Shared Neighborhood Hits	5
SwissProt Accessions	Q61686, Q9CS35, Q9CXD1	Gene names	Cbx5, Hp1a
Domain Architecture
Description	Chromobox protein homolog 5 (Heterochromatin protein 1 homolog alpha) (HP1 alpha).

CBX3_HUMAN
NC score	0.096369 (rank : 24)	θ value	θ > 10 (rank : 32)
Query Neighborhood Hits	23	Target Neighborhood Hits	36	Shared Neighborhood Hits	5
SwissProt Accessions	Q13185, Q96CD7, Q99409, Q9BVS3, Q9P0Z6	Gene names	CBX3
Domain Architecture
Description	Chromobox protein homolog 3 (Heterochromatin protein 1 homolog gamma) (HP1 gamma) (Modifier 2 protein) (HECH).

CBX1_HUMAN
NC score	0.096034 (rank : 25)	θ value	θ > 10 (rank : 28)
Query Neighborhood Hits	23	Target Neighborhood Hits	44	Shared Neighborhood Hits	5
SwissProt Accessions	P83916, P23197	Gene names	CBX1, CBX
Domain Architecture
Description	Chromobox protein homolog 1 (Heterochromatin protein 1 homolog beta) (HP1 beta) (Modifier 1 protein) (M31) (Heterochromatin protein p25) (HP1Hsbeta) (p25beta).

CBX1_MOUSE
NC score	0.096034 (rank : 26)	θ value	θ > 10 (rank : 29)
Query Neighborhood Hits	23	Target Neighborhood Hits	44	Shared Neighborhood Hits	5
SwissProt Accessions	P83917, P23197	Gene names	Cbx1, Cbx
Domain Architecture
Description	Chromobox protein homolog 1 (Heterochromatin protein 1 homolog beta) (HP1 beta) (Modifier 1 protein) (M31) (Heterochromatin protein p25).

CBX5_HUMAN
NC score	0.096011 (rank : 27)	θ value	θ > 10 (rank : 36)
Query Neighborhood Hits	23	Target Neighborhood Hits	70	Shared Neighborhood Hits	5
SwissProt Accessions	P45973	Gene names	CBX5, HP1A
Domain Architecture
Description	Chromobox protein homolog 5 (Heterochromatin protein 1 homolog alpha) (HP1 alpha) (Antigen p25).

CBX7_MOUSE
NC score	0.088274 (rank : 28)	θ value	θ > 10 (rank : 41)
Query Neighborhood Hits	23	Target Neighborhood Hits	38	Shared Neighborhood Hits	5
SwissProt Accessions	Q8VDS3	Gene names	Cbx7, D15Ertd417e
Domain Architecture
Description	Chromobox protein homolog 7.

CBX7_HUMAN
NC score	0.081864 (rank : 29)	θ value	θ > 10 (rank : 40)
Query Neighborhood Hits	23	Target Neighborhood Hits	48	Shared Neighborhood Hits	5
SwissProt Accessions	O95931, Q86T17	Gene names	CBX7
Domain Architecture
Description	Chromobox protein homolog 7.

ACBP_MOUSE
NC score	0.078117 (rank : 30)	θ value	θ > 10 (rank : 27)
Query Neighborhood Hits	23	Target Neighborhood Hits	10	Shared Neighborhood Hits	2
SwissProt Accessions	P31786	Gene names	Dbi
Domain Architecture
Description	Acyl-CoA-binding protein (ACBP) (Diazepam-binding inhibitor) (DBI) (Endozepine) (EP).

ACBP_HUMAN
NC score	0.076942 (rank : 31)	θ value	θ > 10 (rank : 26)
Query Neighborhood Hits	23	Target Neighborhood Hits	12	Shared Neighborhood Hits	2
SwissProt Accessions	P07108, P08869, Q53SQ7, Q6IB48	Gene names	DBI
Domain Architecture
Description	Acyl-CoA-binding protein (ACBP) (Diazepam-binding inhibitor) (DBI) (Endozepine) (EP).

CBX2_MOUSE
NC score	0.074006 (rank : 32)	θ value	θ > 10 (rank : 31)
Query Neighborhood Hits	23	Target Neighborhood Hits	119	Shared Neighborhood Hits	5
SwissProt Accessions	P30658, O35731, Q8CIA0	Gene names	Cbx2, M33
Domain Architecture
Description	Chromobox protein homolog 2 (Modifier 3 protein) (M33).

CRYL1_MOUSE
NC score	0.073627 (rank : 33)	θ value	θ > 10 (rank : 45)
Query Neighborhood Hits	23	Target Neighborhood Hits	12	Shared Neighborhood Hits	2
SwissProt Accessions	Q99KP3, Q542R9, Q8R4W7	Gene names	Cryl1, Cry
Domain Architecture
Description	Lambda-crystallin homolog.

ACBD7_HUMAN
NC score	0.073461 (rank : 34)	θ value	θ > 10 (rank : 25)
Query Neighborhood Hits	23	Target Neighborhood Hits	9	Shared Neighborhood Hits	2
SwissProt Accessions	Q8N6N7	Gene names	ACBD7
Domain Architecture	No domain graphic available
Description	Acyl-CoA-binding domain-containing protein 7.

DBIL5_MOUSE
NC score	0.071924 (rank : 35)	θ value	θ > 10 (rank : 46)
Query Neighborhood Hits	23	Target Neighborhood Hits	9	Shared Neighborhood Hits	2
SwissProt Accessions	O09035	Gene names	Dbil5
Domain Architecture
Description	Diazepam-binding inhibitor-like 5 (Endozepine-like peptide) (ELP).

CBX8_MOUSE
NC score	0.070443 (rank : 36)	θ value	θ > 10 (rank : 43)
Query Neighborhood Hits	23	Target Neighborhood Hits	46	Shared Neighborhood Hits	5
SwissProt Accessions	Q9QXV1	Gene names	Cbx8, Pc3
Domain Architecture
Description	Chromobox protein homolog 8 (Polycomb 3 homolog) (Pc3) (mPc3).

ACBD4_HUMAN
NC score	0.070086 (rank : 37)	θ value	θ > 10 (rank : 24)
Query Neighborhood Hits	23	Target Neighborhood Hits	17	Shared Neighborhood Hits	2
SwissProt Accessions	Q8NC06, Q8IUT1, Q9H8Q4	Gene names	ACBD4
Domain Architecture	No domain graphic available
Description	Acyl-CoA-binding domain-containing protein 4.

CBX8_HUMAN
NC score	0.069541 (rank : 38)	θ value	θ > 10 (rank : 42)
Query Neighborhood Hits	23	Target Neighborhood Hits	67	Shared Neighborhood Hits	5
SwissProt Accessions	Q9HC52, Q96H39, Q9NR07	Gene names	CBX8, PC3, RC1
Domain Architecture
Description	Chromobox protein homolog 8 (Polycomb 3 homolog) (Pc3) (hPc3) (Rectachrome 1).

CBX6_MOUSE
NC score	0.069138 (rank : 39)	θ value	θ > 10 (rank : 39)
Query Neighborhood Hits	23	Target Neighborhood Hits	50	Shared Neighborhood Hits	5
SwissProt Accessions	Q9DBY5, Q8BZH5	Gene names	Cbx6
Domain Architecture
Description	Chromobox protein homolog 6.

CBX6_HUMAN
NC score	0.068505 (rank : 40)	θ value	θ > 10 (rank : 38)
Query Neighborhood Hits	23	Target Neighborhood Hits	104	Shared Neighborhood Hits	5
SwissProt Accessions	O95503, Q96EM5	Gene names	CBX6
Domain Architecture
Description	Chromobox protein homolog 6.

CBX4_MOUSE
NC score	0.066841 (rank : 41)	θ value	θ > 10 (rank : 35)
Query Neighborhood Hits	23	Target Neighborhood Hits	64	Shared Neighborhood Hits	5
SwissProt Accessions	O55187	Gene names	Cbx4, Pc2
Domain Architecture
Description	Chromobox protein homolog 4 (Polycomb 2 homolog) (Pc2) (mPc2).

CBX4_HUMAN
NC score	0.066493 (rank : 42)	θ value	θ > 10 (rank : 34)
Query Neighborhood Hits	23	Target Neighborhood Hits	68	Shared Neighborhood Hits	5
SwissProt Accessions	O00257, Q96C04	Gene names	CBX4
Domain Architecture
Description	Chromobox protein homolog 4 (Polycomb 2 homolog) (Pc2) (hPc2).

CBX2_HUMAN
NC score	0.066070 (rank : 43)	θ value	θ > 10 (rank : 30)
Query Neighborhood Hits	23	Target Neighborhood Hits	264	Shared Neighborhood Hits	5
SwissProt Accessions	Q14781, Q9BTB1	Gene names	CBX2
Domain Architecture	No domain graphic available
Description	Chromobox protein homolog 2.

MPP8_HUMAN
NC score	0.056332 (rank : 44)	θ value	θ > 10 (rank : 49)
Query Neighborhood Hits	23	Target Neighborhood Hits	948	Shared Neighborhood Hits	5
SwissProt Accessions	Q99549, Q86TK3, Q9BTP1	Gene names	MPHOSPH8, MPP8
Domain Architecture	No domain graphic available
Description	M-phase phosphoprotein 8.

COPD_MOUSE
NC score	0.040630 (rank : 45)	θ value	1.81305 (rank : 20)
Query Neighborhood Hits	23	Target Neighborhood Hits	41	Shared Neighborhood Hits	3
SwissProt Accessions	Q5XJY5	Gene names	Arcn1, Copd
Domain Architecture	No domain graphic available
Description	Coatomer subunit delta (Delta-coat protein) (Delta-COP) (Archain).

COPD_HUMAN
NC score	0.040627 (rank : 46)	θ value	1.81305 (rank : 19)
Query Neighborhood Hits	23	Target Neighborhood Hits	40	Shared Neighborhood Hits	3
SwissProt Accessions	P48444, Q52M80	Gene names	ARCN1, COPD
Domain Architecture
Description	Coatomer subunit delta (Delta-coat protein) (Delta-COP) (Archain).

NOVA2_HUMAN
NC score	0.010357 (rank : 47)	θ value	6.88961 (rank : 21)
Query Neighborhood Hits	23	Target Neighborhood Hits	51	Shared Neighborhood Hits	2
SwissProt Accessions	Q9UNW9, O43267, Q9UEA1	Gene names	NOVA2, ANOVA, NOVA3
Domain Architecture
Description	RNA-binding protein Nova-2 (Neuro-oncological ventral antigen 2) (Astrocytic NOVA1-like RNA-binding protein).

EPIPL_HUMAN
NC score	0.007434 (rank : 48)	θ value	8.99809 (rank : 22)
Query Neighborhood Hits	23	Target Neighborhood Hits	73	Shared Neighborhood Hits	2
SwissProt Accessions	P58107, Q76E58	Gene names	EPPK1, EPIPL
Domain Architecture
Description	Epiplakin (450 kDa epidermal antigen).

PLVAP_HUMAN
NC score	0.006718 (rank : 49)	θ value	8.99809 (rank : 23)
Query Neighborhood Hits	23	Target Neighborhood Hits	397	Shared Neighborhood Hits	2
SwissProt Accessions	Q9BX97, Q86VP0, Q8N8Y0, Q8ND68, Q8TER8, Q9BZD5	Gene names	PLVAP, FELS, PV1
Domain Architecture	No domain graphic available
Description	Plasmalemma vesicle-associated protein (Plasmalemma vesicle protein 1) (PV-1) (Fenestrated endothelial-linked structure protein).