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Network neighborhood for query Sequence : COPD_MOUSE

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COPD_MOUSE
SwissProt Accessions	Q5XJY5	Gene names	Arcn1, Copd
Domain Architecture	No domain graphic available
Description	Coatomer subunit delta (Delta-coat protein) (Delta-COP) (Archain).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

COPD_HUMAN
θ value	0 (rank : 1)	NC score	0.999524 (rank : 2)
Query Neighborhood Hits	41	Target Neighborhood Hits	40	Shared Neighborhood Hits	39
SwissProt Accessions	P48444, Q52M80	Gene names	ARCN1, COPD
Domain Architecture
Description	Coatomer subunit delta (Delta-coat protein) (Delta-COP) (Archain).

COPD_MOUSE
θ value	0 (rank : 2)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	41	Target Neighborhood Hits	41	Shared Neighborhood Hits	41
SwissProt Accessions	Q5XJY5	Gene names	Arcn1, Copd
Domain Architecture	No domain graphic available
Description	Coatomer subunit delta (Delta-coat protein) (Delta-COP) (Archain).

AP4M1_HUMAN
θ value	0.00228821 (rank : 3)	NC score	0.226201 (rank : 3)
Query Neighborhood Hits	41	Target Neighborhood Hits	27	Shared Neighborhood Hits	14
SwissProt Accessions	O00189, Q9UHK9	Gene names	AP4M1, MUARP2
Domain Architecture
Description	AP-4 complex subunit mu-1 (Adapter-related protein complex 4 mu-1 subunit) (Mu subunit of AP-4) (AP-4 adapter complex mu subunit) (Mu- adaptin-related protein 2) (mu-ARP2) (mu4).

AP4M1_MOUSE
θ value	0.00228821 (rank : 4)	NC score	0.224768 (rank : 4)
Query Neighborhood Hits	41	Target Neighborhood Hits	23	Shared Neighborhood Hits	14
SwissProt Accessions	Q9JKC7	Gene names	Ap4m1
Domain Architecture
Description	AP-4 complex subunit mu-1 (Adapter-related protein complex 4 mu-1 subunit) (Mu subunit of AP-4) (AP-4 adapter complex mu subunit) (Mu- adaptin-related protein 2) (mu-ARP2) (mu4).

AP1M1_HUMAN
θ value	0.00869519 (rank : 5)	NC score	0.189256 (rank : 7)
Query Neighborhood Hits	41	Target Neighborhood Hits	34	Shared Neighborhood Hits	17
SwissProt Accessions	Q9BXS5	Gene names	AP1M1, CLTNM
Domain Architecture
Description	AP-1 complex subunit mu-1 (Adaptor-related protein complex 1 mu-1 subunit) (Mu-adaptin 1) (Adaptor protein complex AP-1 mu-1 subunit) (Golgi adaptor HA1/AP1 adaptin mu-1 subunit) (Clathrin assembly protein assembly protein complex 1 medium chain 1) (AP-mu chain family member mu1A) (Clathrin coat assembly protein AP47) (Clathrin coat- associated protein AP47).

AP1M1_MOUSE
θ value	0.00869519 (rank : 6)	NC score	0.189449 (rank : 6)
Query Neighborhood Hits	41	Target Neighborhood Hits	34	Shared Neighborhood Hits	17
SwissProt Accessions	P35585	Gene names	Ap1m1, Cltnm
Domain Architecture
Description	AP-1 complex subunit mu-1 (Adaptor-related protein complex 1 mu-1 subunit) (Mu-adaptin 1) (Adaptor protein complex AP-1 mu-1 subunit) (Golgi adaptor HA1/AP1 adaptin mu-1 subunit) (Clathrin assembly protein assembly protein complex 1 medium chain 1) (AP-mu chain family member mu1A) (Clathrin coat assembly protein AP47) (Clathrin coat- associated protein AP47).

AP1M2_HUMAN
θ value	0.0113563 (rank : 7)	NC score	0.189468 (rank : 5)
Query Neighborhood Hits	41	Target Neighborhood Hits	36	Shared Neighborhood Hits	18
SwissProt Accessions	Q9Y6Q5, Q9BSI8	Gene names	AP1M2
Domain Architecture
Description	AP-1 complex subunit mu-2 (Adaptor-related protein complex 1 mu-2 subunit) (Mu-adaptin 2) (Adaptor protein complex AP-1 mu-2 subunit) (Golgi adaptor HA1/AP1 adaptin mu-2 subunit) (Clathrin assembly protein assembly protein complex 1 medium chain 2) (AP-mu chain family member mu1B).

PLEC1_HUMAN
θ value	0.0961366 (rank : 8)	NC score	0.024671 (rank : 37)
Query Neighborhood Hits	41	Target Neighborhood Hits	1326	Shared Neighborhood Hits	12
SwissProt Accessions	Q15149, Q15148, Q16640	Gene names	PLEC1
Domain Architecture
Description	Plectin-1 (PLTN) (PCN) (Hemidesmosomal protein 1) (HD1).

AP1M2_MOUSE
θ value	0.125558 (rank : 9)	NC score	0.174646 (rank : 8)
Query Neighborhood Hits	41	Target Neighborhood Hits	34	Shared Neighborhood Hits	18
SwissProt Accessions	Q9WVP1, Q99LA4, Q9CWP7	Gene names	Ap1m2
Domain Architecture
Description	AP-1 complex subunit mu-2 (Adaptor-related protein complex 1 mu-2 subunit) (Mu-adaptin 2) (Adaptor protein complex AP-1 mu-2 subunit) (Golgi adaptor HA1/AP1 adaptin mu-2 subunit) (Clathrin assembly protein assembly protein complex 1 medium chain 2) (AP-mu chain family member mu1B).

AP2S1_HUMAN
θ value	0.279714 (rank : 10)	NC score	0.119492 (rank : 11)
Query Neighborhood Hits	41	Target Neighborhood Hits	26	Shared Neighborhood Hits	16
SwissProt Accessions	P53680, O75977, Q6PK67	Gene names	AP2S1, AP17, CLAPS2
Domain Architecture
Description	AP-2 complex subunit sigma-1 (Adapter-related protein complex 2 sigma- 1 subunit) (Clathrin coat assembly protein AP17) (Clathrin coat- associated protein AP17) (Plasma membrane adaptor AP-2 17 kDa protein) (HA2 17 kDa subunit) (Clathrin assembly protein 2 small chain).

AP2S1_MOUSE
θ value	0.279714 (rank : 11)	NC score	0.119492 (rank : 12)
Query Neighborhood Hits	41	Target Neighborhood Hits	26	Shared Neighborhood Hits	16
SwissProt Accessions	P62743, P70626, P97626, Q00380	Gene names	Ap2s1, Ap17, Claps2
Domain Architecture	No domain graphic available
Description	AP-2 complex subunit sigma-1 (Adapter-related protein complex 2 sigma- 1 subunit) (Sigma-adaptin 3b) (Clathrin coat assembly protein AP17) (Clathrin coat-associated protein AP17) (Plasma membrane adaptor AP-2 17 kDa protein) (Clathrin assembly protein 2 small chain).

AP4S1_HUMAN
θ value	0.365318 (rank : 12)	NC score	0.118538 (rank : 13)
Query Neighborhood Hits	41	Target Neighborhood Hits	29	Shared Neighborhood Hits	16
SwissProt Accessions	Q9Y587	Gene names	AP4S1
Domain Architecture
Description	AP-4 complex subunit sigma-1 (Adapter-related protein complex 4 sigma- 1 subunit) (Sigma subunit of AP-4) (AP-4 adapter complex sigma subunit).

ICAL_MOUSE
θ value	0.813845 (rank : 13)	NC score	0.064113 (rank : 25)
Query Neighborhood Hits	41	Target Neighborhood Hits	178	Shared Neighborhood Hits	3
SwissProt Accessions	P51125, Q9EQV4, Q9EQV5, Q9QXQ3, Q9QXQ4, Q9R0N1	Gene names	Cast
Domain Architecture
Description	Calpastatin (Calpain inhibitor).

INCE_MOUSE
θ value	1.06291 (rank : 14)	NC score	0.028664 (rank : 33)
Query Neighborhood Hits	41	Target Neighborhood Hits	903	Shared Neighborhood Hits	9
SwissProt Accessions	Q9WU62, Q7TN28, Q8BGN4, Q8CGI4	Gene names	Incenp
Domain Architecture
Description	Inner centromere protein.

AP1S2_HUMAN
θ value	1.38821 (rank : 15)	NC score	0.098128 (rank : 14)
Query Neighborhood Hits	41	Target Neighborhood Hits	31	Shared Neighborhood Hits	18
SwissProt Accessions	P56377, O95326, Q9H2N6	Gene names	AP1S2
Domain Architecture
Description	AP-1 complex subunit sigma-2 (Adapter-related protein complex 1 sigma- 1B subunit) (Sigma-adaptin 1B) (Adaptor protein complex AP-1 sigma-1B subunit) (Golgi adaptor HA1/AP1 adaptin sigma-1B subunit) (Clathrin assembly protein complex 1 sigma-1B small chain) (Sigma 1B subunit of AP-1 clathrin).

PLVAP_MOUSE
θ value	1.38821 (rank : 16)	NC score	0.054592 (rank : 26)
Query Neighborhood Hits	41	Target Neighborhood Hits	210	Shared Neighborhood Hits	5
SwissProt Accessions	Q91VC4, Q99JB1	Gene names	Plvap, Pv1
Domain Architecture	No domain graphic available
Description	Plasmalemma vesicle-associated protein (Plasmalemma vesicle protein 1) (PV-1) (MECA-32 antigen).

CROP_HUMAN
θ value	1.81305 (rank : 17)	NC score	0.046883 (rank : 28)
Query Neighborhood Hits	41	Target Neighborhood Hits	402	Shared Neighborhood Hits	7
SwissProt Accessions	O95232, Q6PHR9, Q9NUY0, Q9P2S7	Gene names	CROP, CREAP1, O48
Domain Architecture	No domain graphic available
Description	Cisplatin resistance-associated overexpressed protein (cAMP regulatory element-associated protein 1) (CRE-associated protein 1) (CREAP-1) (Luc7A) (Okadaic acid-inducible phosphoprotein OA48-18).

CROP_MOUSE
θ value	1.81305 (rank : 18)	NC score	0.046888 (rank : 27)
Query Neighborhood Hits	41	Target Neighborhood Hits	403	Shared Neighborhood Hits	7
SwissProt Accessions	Q5SUF2, Q3U9D5, Q8BUJ5, Q921Z3, Q9CRS7, Q9CTY4	Gene names	Crop
Domain Architecture	No domain graphic available
Description	Cisplatin resistance-associated overexpressed protein.

ECHM_HUMAN
θ value	1.81305 (rank : 19)	NC score	0.040630 (rank : 29)
Query Neighborhood Hits	41	Target Neighborhood Hits	23	Shared Neighborhood Hits	3
SwissProt Accessions	P30084, O00739, Q5VWY1, Q96H54	Gene names	ECHS1
Domain Architecture
Description	Enoyl-CoA hydratase, mitochondrial precursor (EC 4.2.1.17) (Short chain enoyl-CoA hydratase) (SCEH) (Enoyl-CoA hydratase 1).

AP4S1_MOUSE
θ value	2.36792 (rank : 20)	NC score	0.096359 (rank : 15)
Query Neighborhood Hits	41	Target Neighborhood Hits	26	Shared Neighborhood Hits	14
SwissProt Accessions	Q9WVL1	Gene names	Ap4s1
Domain Architecture
Description	AP-4 complex subunit sigma-1 (Adapter-related protein complex 4 sigma- 1 subunit) (Sigma subunit of AP-4) (AP-4 adapter complex sigma subunit).

AP1S2_MOUSE
θ value	3.0926 (rank : 21)	NC score	0.091626 (rank : 18)
Query Neighborhood Hits	41	Target Neighborhood Hits	31	Shared Neighborhood Hits	18
SwissProt Accessions	Q9DB50, Q543R7	Gene names	Ap1s2
Domain Architecture
Description	AP-1 complex subunit sigma-2 (Adapter-related protein complex 1 sigma- 1B subunit) (Sigma-adaptin 1B) (Adaptor protein complex AP-1 sigma-1B subunit) (Golgi adaptor HA1/AP1 adaptin sigma-1B subunit) (Clathrin assembly protein complex 1 sigma-1B small chain) (Sigma 1B subunit of AP-1 clathrin).

I10R1_HUMAN
θ value	4.03905 (rank : 22)	NC score	0.026620 (rank : 35)
Query Neighborhood Hits	41	Target Neighborhood Hits	17	Shared Neighborhood Hits	2
SwissProt Accessions	Q13651	Gene names	IL10RA, IL10R
Domain Architecture	No domain graphic available
Description	Interleukin-10 receptor alpha chain precursor (IL-10R-A) (IL-10R1) (CDw210a antigen).

AP2M1_HUMAN
θ value	5.27518 (rank : 23)	NC score	0.140736 (rank : 9)
Query Neighborhood Hits	41	Target Neighborhood Hits	33	Shared Neighborhood Hits	18
SwissProt Accessions	Q96CW1, P20172, P53679	Gene names	AP2M1, CLAPM1, KIAA0109
Domain Architecture	No domain graphic available
Description	AP-2 complex subunit mu-1 (Adaptin mu-1) (AP-2 mu-2 chain) (Clathrin coat assembly protein AP50) (Clathrin coat-associated protein AP50) (Plasma membrane adaptor AP-2 50 kDa protein) (HA2 50 kDa subunit) (Clathrin assembly protein complex 2 medium chain).

AP2M1_MOUSE
θ value	5.27518 (rank : 24)	NC score	0.140736 (rank : 10)
Query Neighborhood Hits	41	Target Neighborhood Hits	33	Shared Neighborhood Hits	18
SwissProt Accessions	P84091, P20172, P53679	Gene names	Ap2m1, Clapm1
Domain Architecture	No domain graphic available
Description	AP-2 complex subunit mu-1 (Adaptin mu-1) (AP-2 mu-2 chain) (Clathrin coat assembly protein AP50) (Clathrin coat-associated protein AP50) (Plasma membrane adaptor AP-2 50 kDa protein) (Clathrin assembly protein complex 2 medium chain).

IF16_HUMAN
θ value	5.27518 (rank : 25)	NC score	0.028694 (rank : 32)
Query Neighborhood Hits	41	Target Neighborhood Hits	182	Shared Neighborhood Hits	3
SwissProt Accessions	Q16666, Q9UH78	Gene names	IFI16, IFNGIP1
Domain Architecture
Description	Gamma-interferon-inducible protein Ifi-16 (Interferon-inducible myeloid differentiation transcriptional activator) (IFI 16).

KI21A_HUMAN
θ value	5.27518 (rank : 26)	NC score	0.010397 (rank : 41)
Query Neighborhood Hits	41	Target Neighborhood Hits	1543	Shared Neighborhood Hits	14
SwissProt Accessions	Q7Z4S6, Q6UKL9, Q7Z668, Q86WZ5, Q8IVZ8, Q9C0F5, Q9NXU4, Q9Y590	Gene names	KIF21A, KIAA1708, KIF2
Domain Architecture	No domain graphic available
Description	Kinesin family member 21A (Kinesin-like protein KIF2) (NY-REN-62 antigen).

GLE1_HUMAN
θ value	6.88961 (rank : 27)	NC score	0.027336 (rank : 34)
Query Neighborhood Hits	41	Target Neighborhood Hits	445	Shared Neighborhood Hits	8
SwissProt Accessions	Q53GS7, O75458, Q53GT9, Q5VVU1, Q8NCP6, Q9UFL6	Gene names	GLE1L, GLE1
Domain Architecture	No domain graphic available
Description	Nucleoporin GLE1 (GLE1-like protein) (hGLE1).

IDLC_MOUSE
θ value	6.88961 (rank : 28)	NC score	0.038132 (rank : 30)
Query Neighborhood Hits	41	Target Neighborhood Hits	321	Shared Neighborhood Hits	10
SwissProt Accessions	Q8BVN8	Gene names	Dnali1
Domain Architecture	No domain graphic available
Description	Axonemal dynein light intermediate polypeptide 1 (Inner dynein arm light chain, axonemal).

MAP2_MOUSE
θ value	6.88961 (rank : 29)	NC score	0.013841 (rank : 39)
Query Neighborhood Hits	41	Target Neighborhood Hits	342	Shared Neighborhood Hits	5
SwissProt Accessions	P20357	Gene names	Map2, Mtap2
Domain Architecture
Description	Microtubule-associated protein 2 (MAP 2).

PP16A_HUMAN
θ value	6.88961 (rank : 30)	NC score	0.009012 (rank : 43)
Query Neighborhood Hits	41	Target Neighborhood Hits	340	Shared Neighborhood Hits	3
SwissProt Accessions	Q96I34	Gene names	PPP1R16A, MYPT3
Domain Architecture
Description	Protein phosphatase 1 regulatory subunit 16A (Myosin phosphatase- targeting subunit 3).

SOX5_HUMAN
θ value	6.88961 (rank : 31)	NC score	0.012537 (rank : 40)
Query Neighborhood Hits	41	Target Neighborhood Hits	219	Shared Neighborhood Hits	3
SwissProt Accessions	P35711, Q86UK8, Q8J017, Q8J018, Q8J019, Q8J020, Q8N1D9, Q8N7E0, Q8TEA4	Gene names	SOX5
Domain Architecture
Description	Transcription factor SOX-5.

TRHY_HUMAN
θ value	6.88961 (rank : 32)	NC score	0.007565 (rank : 44)
Query Neighborhood Hits	41	Target Neighborhood Hits	1385	Shared Neighborhood Hits	11
SwissProt Accessions	Q07283	Gene names	THH, THL, TRHY
Domain Architecture
Description	Trichohyalin.

AP1S1_HUMAN
θ value	8.99809 (rank : 33)	NC score	0.080798 (rank : 21)
Query Neighborhood Hits	41	Target Neighborhood Hits	30	Shared Neighborhood Hits	18
SwissProt Accessions	P61966, P82267, Q00382, Q9BTN4, Q9UDW9	Gene names	AP1S1, AP19, CLAPS1
Domain Architecture
Description	AP-1 complex subunit sigma-1A (Adapter-related protein complex 1 sigma-1A subunit) (Sigma-adaptin 1A) (Adaptor protein complex AP-1 sigma-1A subunit) (Golgi adaptor HA1/AP1 adaptin sigma-1A subunit) (Clathrin assembly protein complex 1 sigma-1A small chain) (Clathrin coat assembly protein AP19) (HA1 19 kDa subunit) (Sigma 1a subunit of AP-1 clathrin).

AP1S1_MOUSE
θ value	8.99809 (rank : 34)	NC score	0.080798 (rank : 22)
Query Neighborhood Hits	41	Target Neighborhood Hits	30	Shared Neighborhood Hits	18
SwissProt Accessions	P61967, P82267, Q00382, Q9BTN4, Q9UDW9	Gene names	Ap1s1, Ap19
Domain Architecture
Description	AP-1 complex subunit sigma-1A (Adapter-related protein complex 1 sigma-1A subunit) (Sigma-adaptin 1A) (Adaptor protein complex AP-1 sigma-1A subunit) (Golgi adaptor HA1/AP1 adaptin sigma-1A subunit) (Clathrin assembly protein complex 1 sigma-1A small chain) (Clathrin coat assembly protein AP19) (HA1 19 kDa subunit) (Sigma 1a subunit of AP-1 clathrin).

CD2L1_HUMAN
θ value	8.99809 (rank : 35)	NC score	0.002919 (rank : 46)
Query Neighborhood Hits	41	Target Neighborhood Hits	1467	Shared Neighborhood Hits	10
SwissProt Accessions	P21127, O95265, Q12817, Q12818, Q12819, Q12820, Q12822, Q8N530, Q9NZS5, Q9UBJ0, Q9UBQ1, Q9UBR0, Q9UNY2, Q9UP57, Q9UP58, Q9UP59	Gene names	CDC2L1, PITSLREA, PK58
Domain Architecture
Description	PITSLRE serine/threonine-protein kinase CDC2L1 (EC 2.7.11.22) (Galactosyltransferase-associated protein kinase p58/GTA) (Cell division cycle 2-like protein kinase 1) (CLK-1) (CDK11) (p58 CLK-1).

CD2L2_HUMAN
θ value	8.99809 (rank : 36)	NC score	0.002917 (rank : 47)
Query Neighborhood Hits	41	Target Neighborhood Hits	1439	Shared Neighborhood Hits	10
SwissProt Accessions	Q9UQ88, O95227, O95228, O96012, Q12821, Q12853, Q12854, Q5QPR0, Q5QPR1, Q5QPR2, Q9UBC4, Q9UBI3, Q9UEI1, Q9UEI2, Q9UP53, Q9UP54, Q9UP55, Q9UP56, Q9UQ86, Q9UQ87, Q9UQ89	Gene names	CDC2L2, PITSLREB
Domain Architecture
Description	PITSLRE serine/threonine-protein kinase CDC2L2 (EC 2.7.11.22) (Galactosyltransferase-associated protein kinase p58/GTA) (Cell division cycle 2-like protein kinase 2) (CDK11).

DESM_HUMAN
θ value	8.99809 (rank : 37)	NC score	0.005765 (rank : 45)
Query Neighborhood Hits	41	Target Neighborhood Hits	495	Shared Neighborhood Hits	5
SwissProt Accessions	P17661, Q15787, Q8IZR1, Q8IZR6, Q8NES2, Q8NEU6, Q8TAC4, Q8TCX2, Q8TD99, Q9UHN5, Q9UJ80	Gene names	DES
Domain Architecture
Description	Desmin.

FREM1_HUMAN
θ value	8.99809 (rank : 38)	NC score	0.010386 (rank : 42)
Query Neighborhood Hits	41	Target Neighborhood Hits	170	Shared Neighborhood Hits	3
SwissProt Accessions	Q5H8C1, Q5VV00, Q5VV01, Q6MZI4, Q8NEG9, Q96LI3	Gene names	FREM1, C9orf154
Domain Architecture	No domain graphic available
Description	FRAS1-related extracellular matrix protein 1 precursor (Protein QBRICK).

IDLC_HUMAN
θ value	8.99809 (rank : 39)	NC score	0.033712 (rank : 31)
Query Neighborhood Hits	41	Target Neighborhood Hits	348	Shared Neighborhood Hits	10
SwissProt Accessions	O14645, Q5TGH0, Q7L0I5	Gene names	DNALI1
Domain Architecture	No domain graphic available
Description	Axonemal dynein light intermediate polypeptide 1 (Inner dynein arm light chain, axonemal) (hp28).

LRC27_HUMAN
θ value	8.99809 (rank : 40)	NC score	0.018268 (rank : 38)
Query Neighborhood Hits	41	Target Neighborhood Hits	710	Shared Neighborhood Hits	11
SwissProt Accessions	Q9C0I9, Q5SZH6, Q5SZH8, Q5SZH9, Q86XT5, Q8N7C8, Q8NA21	Gene names	LRRC27, KIAA1674
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 27.

SGIP1_HUMAN
θ value	8.99809 (rank : 41)	NC score	0.025672 (rank : 36)
Query Neighborhood Hits	41	Target Neighborhood Hits	198	Shared Neighborhood Hits	3
SwissProt Accessions	Q9BQI5, Q4LE32, Q5VYE2, Q5VYE3, Q5VYE4, Q68D76, Q6MZY6, Q8IWC2	Gene names	SGIP1
Domain Architecture	No domain graphic available
Description	SH3-containing GRB2-like protein 3-interacting protein 1 (Endophilin- 3-interacting protein).

AP1S3_HUMAN
θ value	θ > 10 (rank : 42)	NC score	0.067248 (rank : 23)
Query Neighborhood Hits	41	Target Neighborhood Hits	30	Shared Neighborhood Hits	16
SwissProt Accessions	Q96PC3, Q8WTY1, Q96DD1	Gene names	AP1S3
Domain Architecture
Description	AP-1 complex subunit sigma-3 (Adapter-related protein complex 1 sigma- 1C subunit) (Sigma-adaptin 1C) (Adaptor protein complex AP-1 sigma-1C subunit) (Golgi adaptor HA1/AP1 adaptin sigma-1C subunit) (Clathrin assembly protein complex 1 sigma-1C small chain) (Sigma 1C subunit of AP-1 clathrin).

AP1S3_MOUSE
θ value	θ > 10 (rank : 43)	NC score	0.066430 (rank : 24)
Query Neighborhood Hits	41	Target Neighborhood Hits	30	Shared Neighborhood Hits	16
SwissProt Accessions	Q7TN05	Gene names	Ap1s3
Domain Architecture	No domain graphic available
Description	AP-1 complex subunit sigma-3 (Adapter-related protein complex 1 sigma- 1C subunit) (Sigma-adaptin 1C) (Adaptor protein complex AP-1 sigma-1C subunit) (Golgi adaptor HA1/AP1 adaptin sigma-1C subunit) (Clathrin assembly protein complex 1 sigma-1C small chain) (Sigma 1C subunit of AP-1 clathrin).

AP3M1_HUMAN
θ value	θ > 10 (rank : 44)	NC score	0.094883 (rank : 16)
Query Neighborhood Hits	41	Target Neighborhood Hits	30	Shared Neighborhood Hits	16
SwissProt Accessions	Q9Y2T2	Gene names	AP3M1
Domain Architecture
Description	AP-3 complex subunit mu-1 (Adapter-related protein complex 3 mu-1 subunit) (Mu-adaptin 3A) (AP-3 adapter complex mu3A subunit).

AP3M1_MOUSE
θ value	θ > 10 (rank : 45)	NC score	0.094747 (rank : 17)
Query Neighborhood Hits	41	Target Neighborhood Hits	30	Shared Neighborhood Hits	16
SwissProt Accessions	Q9JKC8, Q5BKQ6	Gene names	Ap3m1
Domain Architecture
Description	AP-3 complex subunit mu-1 (Adapter-related protein complex 3 mu-1 subunit) (Mu-adaptin 3A) (AP-3 adapter complex mu3A subunit).

AP3M2_HUMAN
θ value	θ > 10 (rank : 46)	NC score	0.090668 (rank : 20)
Query Neighborhood Hits	41	Target Neighborhood Hits	32	Shared Neighborhood Hits	16
SwissProt Accessions	P53677	Gene names	AP3M2
Domain Architecture
Description	AP-3 complex subunit mu-2 (Adapter-related protein complex 3 mu-2 subunit) (Clathrin coat assembly protein AP47 homolog 2) (Clathrin coat-associated protein AP47 homolog 2) (Golgi adaptor AP-1 47 kDa protein homolog 2) (HA1 47 kDa subunit homolog 2) (Clathrin assembly protein assembly protein complex 1 medium chain homolog 2) (P47B).

AP3M2_MOUSE
θ value	θ > 10 (rank : 47)	NC score	0.090892 (rank : 19)
Query Neighborhood Hits	41	Target Neighborhood Hits	30	Shared Neighborhood Hits	16
SwissProt Accessions	Q8R2R9, Q3UYJ3, Q923G7	Gene names	Ap3m2
Domain Architecture	No domain graphic available
Description	AP-3 complex subunit mu-2 (Adapter-related protein complex 3 mu-2 subunit) (Clathrin coat assembly protein AP47 homolog 2) (Clathrin coat-associated protein AP47 homolog 2) (Golgi adaptor AP-1 47 kDa protein homolog 2) (HA1 47 kDa subunit homolog 2) (Clathrin assembly protein assembly protein complex 1 medium chain homolog 2) (P47B) (m3B).

Hits sorted by NC score

COPD_MOUSE
NC score	0.999962 (rank : 1)	θ value	0 (rank : 2)
Query Neighborhood Hits	41	Target Neighborhood Hits	41	Shared Neighborhood Hits	41
SwissProt Accessions	Q5XJY5	Gene names	Arcn1, Copd
Domain Architecture	No domain graphic available
Description	Coatomer subunit delta (Delta-coat protein) (Delta-COP) (Archain).

COPD_HUMAN
NC score	0.999524 (rank : 2)	θ value	0 (rank : 1)
Query Neighborhood Hits	41	Target Neighborhood Hits	40	Shared Neighborhood Hits	39
SwissProt Accessions	P48444, Q52M80	Gene names	ARCN1, COPD
Domain Architecture
Description	Coatomer subunit delta (Delta-coat protein) (Delta-COP) (Archain).

AP4M1_HUMAN
NC score	0.226201 (rank : 3)	θ value	0.00228821 (rank : 3)
Query Neighborhood Hits	41	Target Neighborhood Hits	27	Shared Neighborhood Hits	14
SwissProt Accessions	O00189, Q9UHK9	Gene names	AP4M1, MUARP2
Domain Architecture
Description	AP-4 complex subunit mu-1 (Adapter-related protein complex 4 mu-1 subunit) (Mu subunit of AP-4) (AP-4 adapter complex mu subunit) (Mu- adaptin-related protein 2) (mu-ARP2) (mu4).

AP4M1_MOUSE
NC score	0.224768 (rank : 4)	θ value	0.00228821 (rank : 4)
Query Neighborhood Hits	41	Target Neighborhood Hits	23	Shared Neighborhood Hits	14
SwissProt Accessions	Q9JKC7	Gene names	Ap4m1
Domain Architecture
Description	AP-4 complex subunit mu-1 (Adapter-related protein complex 4 mu-1 subunit) (Mu subunit of AP-4) (AP-4 adapter complex mu subunit) (Mu- adaptin-related protein 2) (mu-ARP2) (mu4).

AP1M2_HUMAN
NC score	0.189468 (rank : 5)	θ value	0.0113563 (rank : 7)
Query Neighborhood Hits	41	Target Neighborhood Hits	36	Shared Neighborhood Hits	18
SwissProt Accessions	Q9Y6Q5, Q9BSI8	Gene names	AP1M2
Domain Architecture
Description	AP-1 complex subunit mu-2 (Adaptor-related protein complex 1 mu-2 subunit) (Mu-adaptin 2) (Adaptor protein complex AP-1 mu-2 subunit) (Golgi adaptor HA1/AP1 adaptin mu-2 subunit) (Clathrin assembly protein assembly protein complex 1 medium chain 2) (AP-mu chain family member mu1B).

AP1M1_MOUSE
NC score	0.189449 (rank : 6)	θ value	0.00869519 (rank : 6)
Query Neighborhood Hits	41	Target Neighborhood Hits	34	Shared Neighborhood Hits	17
SwissProt Accessions	P35585	Gene names	Ap1m1, Cltnm
Domain Architecture
Description	AP-1 complex subunit mu-1 (Adaptor-related protein complex 1 mu-1 subunit) (Mu-adaptin 1) (Adaptor protein complex AP-1 mu-1 subunit) (Golgi adaptor HA1/AP1 adaptin mu-1 subunit) (Clathrin assembly protein assembly protein complex 1 medium chain 1) (AP-mu chain family member mu1A) (Clathrin coat assembly protein AP47) (Clathrin coat- associated protein AP47).

AP1M1_HUMAN
NC score	0.189256 (rank : 7)	θ value	0.00869519 (rank : 5)
Query Neighborhood Hits	41	Target Neighborhood Hits	34	Shared Neighborhood Hits	17
SwissProt Accessions	Q9BXS5	Gene names	AP1M1, CLTNM
Domain Architecture
Description	AP-1 complex subunit mu-1 (Adaptor-related protein complex 1 mu-1 subunit) (Mu-adaptin 1) (Adaptor protein complex AP-1 mu-1 subunit) (Golgi adaptor HA1/AP1 adaptin mu-1 subunit) (Clathrin assembly protein assembly protein complex 1 medium chain 1) (AP-mu chain family member mu1A) (Clathrin coat assembly protein AP47) (Clathrin coat- associated protein AP47).

AP1M2_MOUSE
NC score	0.174646 (rank : 8)	θ value	0.125558 (rank : 9)
Query Neighborhood Hits	41	Target Neighborhood Hits	34	Shared Neighborhood Hits	18
SwissProt Accessions	Q9WVP1, Q99LA4, Q9CWP7	Gene names	Ap1m2
Domain Architecture
Description	AP-1 complex subunit mu-2 (Adaptor-related protein complex 1 mu-2 subunit) (Mu-adaptin 2) (Adaptor protein complex AP-1 mu-2 subunit) (Golgi adaptor HA1/AP1 adaptin mu-2 subunit) (Clathrin assembly protein assembly protein complex 1 medium chain 2) (AP-mu chain family member mu1B).

AP2M1_HUMAN
NC score	0.140736 (rank : 9)	θ value	5.27518 (rank : 23)
Query Neighborhood Hits	41	Target Neighborhood Hits	33	Shared Neighborhood Hits	18
SwissProt Accessions	Q96CW1, P20172, P53679	Gene names	AP2M1, CLAPM1, KIAA0109
Domain Architecture	No domain graphic available
Description	AP-2 complex subunit mu-1 (Adaptin mu-1) (AP-2 mu-2 chain) (Clathrin coat assembly protein AP50) (Clathrin coat-associated protein AP50) (Plasma membrane adaptor AP-2 50 kDa protein) (HA2 50 kDa subunit) (Clathrin assembly protein complex 2 medium chain).

AP2M1_MOUSE
NC score	0.140736 (rank : 10)	θ value	5.27518 (rank : 24)
Query Neighborhood Hits	41	Target Neighborhood Hits	33	Shared Neighborhood Hits	18
SwissProt Accessions	P84091, P20172, P53679	Gene names	Ap2m1, Clapm1
Domain Architecture	No domain graphic available
Description	AP-2 complex subunit mu-1 (Adaptin mu-1) (AP-2 mu-2 chain) (Clathrin coat assembly protein AP50) (Clathrin coat-associated protein AP50) (Plasma membrane adaptor AP-2 50 kDa protein) (Clathrin assembly protein complex 2 medium chain).

AP2S1_HUMAN
NC score	0.119492 (rank : 11)	θ value	0.279714 (rank : 10)
Query Neighborhood Hits	41	Target Neighborhood Hits	26	Shared Neighborhood Hits	16
SwissProt Accessions	P53680, O75977, Q6PK67	Gene names	AP2S1, AP17, CLAPS2
Domain Architecture
Description	AP-2 complex subunit sigma-1 (Adapter-related protein complex 2 sigma- 1 subunit) (Clathrin coat assembly protein AP17) (Clathrin coat- associated protein AP17) (Plasma membrane adaptor AP-2 17 kDa protein) (HA2 17 kDa subunit) (Clathrin assembly protein 2 small chain).

AP2S1_MOUSE
NC score	0.119492 (rank : 12)	θ value	0.279714 (rank : 11)
Query Neighborhood Hits	41	Target Neighborhood Hits	26	Shared Neighborhood Hits	16
SwissProt Accessions	P62743, P70626, P97626, Q00380	Gene names	Ap2s1, Ap17, Claps2
Domain Architecture	No domain graphic available
Description	AP-2 complex subunit sigma-1 (Adapter-related protein complex 2 sigma- 1 subunit) (Sigma-adaptin 3b) (Clathrin coat assembly protein AP17) (Clathrin coat-associated protein AP17) (Plasma membrane adaptor AP-2 17 kDa protein) (Clathrin assembly protein 2 small chain).

AP4S1_HUMAN
NC score	0.118538 (rank : 13)	θ value	0.365318 (rank : 12)
Query Neighborhood Hits	41	Target Neighborhood Hits	29	Shared Neighborhood Hits	16
SwissProt Accessions	Q9Y587	Gene names	AP4S1
Domain Architecture
Description	AP-4 complex subunit sigma-1 (Adapter-related protein complex 4 sigma- 1 subunit) (Sigma subunit of AP-4) (AP-4 adapter complex sigma subunit).

AP1S2_HUMAN
NC score	0.098128 (rank : 14)	θ value	1.38821 (rank : 15)
Query Neighborhood Hits	41	Target Neighborhood Hits	31	Shared Neighborhood Hits	18
SwissProt Accessions	P56377, O95326, Q9H2N6	Gene names	AP1S2
Domain Architecture
Description	AP-1 complex subunit sigma-2 (Adapter-related protein complex 1 sigma- 1B subunit) (Sigma-adaptin 1B) (Adaptor protein complex AP-1 sigma-1B subunit) (Golgi adaptor HA1/AP1 adaptin sigma-1B subunit) (Clathrin assembly protein complex 1 sigma-1B small chain) (Sigma 1B subunit of AP-1 clathrin).

AP4S1_MOUSE
NC score	0.096359 (rank : 15)	θ value	2.36792 (rank : 20)
Query Neighborhood Hits	41	Target Neighborhood Hits	26	Shared Neighborhood Hits	14
SwissProt Accessions	Q9WVL1	Gene names	Ap4s1
Domain Architecture
Description	AP-4 complex subunit sigma-1 (Adapter-related protein complex 4 sigma- 1 subunit) (Sigma subunit of AP-4) (AP-4 adapter complex sigma subunit).

AP3M1_HUMAN
NC score	0.094883 (rank : 16)	θ value	θ > 10 (rank : 44)
Query Neighborhood Hits	41	Target Neighborhood Hits	30	Shared Neighborhood Hits	16
SwissProt Accessions	Q9Y2T2	Gene names	AP3M1
Domain Architecture
Description	AP-3 complex subunit mu-1 (Adapter-related protein complex 3 mu-1 subunit) (Mu-adaptin 3A) (AP-3 adapter complex mu3A subunit).

AP3M1_MOUSE
NC score	0.094747 (rank : 17)	θ value	θ > 10 (rank : 45)
Query Neighborhood Hits	41	Target Neighborhood Hits	30	Shared Neighborhood Hits	16
SwissProt Accessions	Q9JKC8, Q5BKQ6	Gene names	Ap3m1
Domain Architecture
Description	AP-3 complex subunit mu-1 (Adapter-related protein complex 3 mu-1 subunit) (Mu-adaptin 3A) (AP-3 adapter complex mu3A subunit).

AP1S2_MOUSE
NC score	0.091626 (rank : 18)	θ value	3.0926 (rank : 21)
Query Neighborhood Hits	41	Target Neighborhood Hits	31	Shared Neighborhood Hits	18
SwissProt Accessions	Q9DB50, Q543R7	Gene names	Ap1s2
Domain Architecture
Description	AP-1 complex subunit sigma-2 (Adapter-related protein complex 1 sigma- 1B subunit) (Sigma-adaptin 1B) (Adaptor protein complex AP-1 sigma-1B subunit) (Golgi adaptor HA1/AP1 adaptin sigma-1B subunit) (Clathrin assembly protein complex 1 sigma-1B small chain) (Sigma 1B subunit of AP-1 clathrin).

AP3M2_MOUSE
NC score	0.090892 (rank : 19)	θ value	θ > 10 (rank : 47)
Query Neighborhood Hits	41	Target Neighborhood Hits	30	Shared Neighborhood Hits	16
SwissProt Accessions	Q8R2R9, Q3UYJ3, Q923G7	Gene names	Ap3m2
Domain Architecture	No domain graphic available
Description	AP-3 complex subunit mu-2 (Adapter-related protein complex 3 mu-2 subunit) (Clathrin coat assembly protein AP47 homolog 2) (Clathrin coat-associated protein AP47 homolog 2) (Golgi adaptor AP-1 47 kDa protein homolog 2) (HA1 47 kDa subunit homolog 2) (Clathrin assembly protein assembly protein complex 1 medium chain homolog 2) (P47B) (m3B).

AP3M2_HUMAN
NC score	0.090668 (rank : 20)	θ value	θ > 10 (rank : 46)
Query Neighborhood Hits	41	Target Neighborhood Hits	32	Shared Neighborhood Hits	16
SwissProt Accessions	P53677	Gene names	AP3M2
Domain Architecture
Description	AP-3 complex subunit mu-2 (Adapter-related protein complex 3 mu-2 subunit) (Clathrin coat assembly protein AP47 homolog 2) (Clathrin coat-associated protein AP47 homolog 2) (Golgi adaptor AP-1 47 kDa protein homolog 2) (HA1 47 kDa subunit homolog 2) (Clathrin assembly protein assembly protein complex 1 medium chain homolog 2) (P47B).

AP1S1_HUMAN
NC score	0.080798 (rank : 21)	θ value	8.99809 (rank : 33)
Query Neighborhood Hits	41	Target Neighborhood Hits	30	Shared Neighborhood Hits	18
SwissProt Accessions	P61966, P82267, Q00382, Q9BTN4, Q9UDW9	Gene names	AP1S1, AP19, CLAPS1
Domain Architecture
Description	AP-1 complex subunit sigma-1A (Adapter-related protein complex 1 sigma-1A subunit) (Sigma-adaptin 1A) (Adaptor protein complex AP-1 sigma-1A subunit) (Golgi adaptor HA1/AP1 adaptin sigma-1A subunit) (Clathrin assembly protein complex 1 sigma-1A small chain) (Clathrin coat assembly protein AP19) (HA1 19 kDa subunit) (Sigma 1a subunit of AP-1 clathrin).

AP1S1_MOUSE
NC score	0.080798 (rank : 22)	θ value	8.99809 (rank : 34)
Query Neighborhood Hits	41	Target Neighborhood Hits	30	Shared Neighborhood Hits	18
SwissProt Accessions	P61967, P82267, Q00382, Q9BTN4, Q9UDW9	Gene names	Ap1s1, Ap19
Domain Architecture
Description	AP-1 complex subunit sigma-1A (Adapter-related protein complex 1 sigma-1A subunit) (Sigma-adaptin 1A) (Adaptor protein complex AP-1 sigma-1A subunit) (Golgi adaptor HA1/AP1 adaptin sigma-1A subunit) (Clathrin assembly protein complex 1 sigma-1A small chain) (Clathrin coat assembly protein AP19) (HA1 19 kDa subunit) (Sigma 1a subunit of AP-1 clathrin).

AP1S3_HUMAN
NC score	0.067248 (rank : 23)	θ value	θ > 10 (rank : 42)
Query Neighborhood Hits	41	Target Neighborhood Hits	30	Shared Neighborhood Hits	16
SwissProt Accessions	Q96PC3, Q8WTY1, Q96DD1	Gene names	AP1S3
Domain Architecture
Description	AP-1 complex subunit sigma-3 (Adapter-related protein complex 1 sigma- 1C subunit) (Sigma-adaptin 1C) (Adaptor protein complex AP-1 sigma-1C subunit) (Golgi adaptor HA1/AP1 adaptin sigma-1C subunit) (Clathrin assembly protein complex 1 sigma-1C small chain) (Sigma 1C subunit of AP-1 clathrin).

AP1S3_MOUSE
NC score	0.066430 (rank : 24)	θ value	θ > 10 (rank : 43)
Query Neighborhood Hits	41	Target Neighborhood Hits	30	Shared Neighborhood Hits	16
SwissProt Accessions	Q7TN05	Gene names	Ap1s3
Domain Architecture	No domain graphic available
Description	AP-1 complex subunit sigma-3 (Adapter-related protein complex 1 sigma- 1C subunit) (Sigma-adaptin 1C) (Adaptor protein complex AP-1 sigma-1C subunit) (Golgi adaptor HA1/AP1 adaptin sigma-1C subunit) (Clathrin assembly protein complex 1 sigma-1C small chain) (Sigma 1C subunit of AP-1 clathrin).

ICAL_MOUSE
NC score	0.064113 (rank : 25)	θ value	0.813845 (rank : 13)
Query Neighborhood Hits	41	Target Neighborhood Hits	178	Shared Neighborhood Hits	3
SwissProt Accessions	P51125, Q9EQV4, Q9EQV5, Q9QXQ3, Q9QXQ4, Q9R0N1	Gene names	Cast
Domain Architecture
Description	Calpastatin (Calpain inhibitor).

PLVAP_MOUSE
NC score	0.054592 (rank : 26)	θ value	1.38821 (rank : 16)
Query Neighborhood Hits	41	Target Neighborhood Hits	210	Shared Neighborhood Hits	5
SwissProt Accessions	Q91VC4, Q99JB1	Gene names	Plvap, Pv1
Domain Architecture	No domain graphic available
Description	Plasmalemma vesicle-associated protein (Plasmalemma vesicle protein 1) (PV-1) (MECA-32 antigen).

CROP_MOUSE
NC score	0.046888 (rank : 27)	θ value	1.81305 (rank : 18)
Query Neighborhood Hits	41	Target Neighborhood Hits	403	Shared Neighborhood Hits	7
SwissProt Accessions	Q5SUF2, Q3U9D5, Q8BUJ5, Q921Z3, Q9CRS7, Q9CTY4	Gene names	Crop
Domain Architecture	No domain graphic available
Description	Cisplatin resistance-associated overexpressed protein.

CROP_HUMAN
NC score	0.046883 (rank : 28)	θ value	1.81305 (rank : 17)
Query Neighborhood Hits	41	Target Neighborhood Hits	402	Shared Neighborhood Hits	7
SwissProt Accessions	O95232, Q6PHR9, Q9NUY0, Q9P2S7	Gene names	CROP, CREAP1, O48
Domain Architecture	No domain graphic available
Description	Cisplatin resistance-associated overexpressed protein (cAMP regulatory element-associated protein 1) (CRE-associated protein 1) (CREAP-1) (Luc7A) (Okadaic acid-inducible phosphoprotein OA48-18).

ECHM_HUMAN
NC score	0.040630 (rank : 29)	θ value	1.81305 (rank : 19)
Query Neighborhood Hits	41	Target Neighborhood Hits	23	Shared Neighborhood Hits	3
SwissProt Accessions	P30084, O00739, Q5VWY1, Q96H54	Gene names	ECHS1
Domain Architecture
Description	Enoyl-CoA hydratase, mitochondrial precursor (EC 4.2.1.17) (Short chain enoyl-CoA hydratase) (SCEH) (Enoyl-CoA hydratase 1).

IDLC_MOUSE
NC score	0.038132 (rank : 30)	θ value	6.88961 (rank : 28)
Query Neighborhood Hits	41	Target Neighborhood Hits	321	Shared Neighborhood Hits	10
SwissProt Accessions	Q8BVN8	Gene names	Dnali1
Domain Architecture	No domain graphic available
Description	Axonemal dynein light intermediate polypeptide 1 (Inner dynein arm light chain, axonemal).

IDLC_HUMAN
NC score	0.033712 (rank : 31)	θ value	8.99809 (rank : 39)
Query Neighborhood Hits	41	Target Neighborhood Hits	348	Shared Neighborhood Hits	10
SwissProt Accessions	O14645, Q5TGH0, Q7L0I5	Gene names	DNALI1
Domain Architecture	No domain graphic available
Description	Axonemal dynein light intermediate polypeptide 1 (Inner dynein arm light chain, axonemal) (hp28).

IF16_HUMAN
NC score	0.028694 (rank : 32)	θ value	5.27518 (rank : 25)
Query Neighborhood Hits	41	Target Neighborhood Hits	182	Shared Neighborhood Hits	3
SwissProt Accessions	Q16666, Q9UH78	Gene names	IFI16, IFNGIP1
Domain Architecture
Description	Gamma-interferon-inducible protein Ifi-16 (Interferon-inducible myeloid differentiation transcriptional activator) (IFI 16).

INCE_MOUSE
NC score	0.028664 (rank : 33)	θ value	1.06291 (rank : 14)
Query Neighborhood Hits	41	Target Neighborhood Hits	903	Shared Neighborhood Hits	9
SwissProt Accessions	Q9WU62, Q7TN28, Q8BGN4, Q8CGI4	Gene names	Incenp
Domain Architecture
Description	Inner centromere protein.

GLE1_HUMAN
NC score	0.027336 (rank : 34)	θ value	6.88961 (rank : 27)
Query Neighborhood Hits	41	Target Neighborhood Hits	445	Shared Neighborhood Hits	8
SwissProt Accessions	Q53GS7, O75458, Q53GT9, Q5VVU1, Q8NCP6, Q9UFL6	Gene names	GLE1L, GLE1
Domain Architecture	No domain graphic available
Description	Nucleoporin GLE1 (GLE1-like protein) (hGLE1).

I10R1_HUMAN
NC score	0.026620 (rank : 35)	θ value	4.03905 (rank : 22)
Query Neighborhood Hits	41	Target Neighborhood Hits	17	Shared Neighborhood Hits	2
SwissProt Accessions	Q13651	Gene names	IL10RA, IL10R
Domain Architecture	No domain graphic available
Description	Interleukin-10 receptor alpha chain precursor (IL-10R-A) (IL-10R1) (CDw210a antigen).

SGIP1_HUMAN
NC score	0.025672 (rank : 36)	θ value	8.99809 (rank : 41)
Query Neighborhood Hits	41	Target Neighborhood Hits	198	Shared Neighborhood Hits	3
SwissProt Accessions	Q9BQI5, Q4LE32, Q5VYE2, Q5VYE3, Q5VYE4, Q68D76, Q6MZY6, Q8IWC2	Gene names	SGIP1
Domain Architecture	No domain graphic available
Description	SH3-containing GRB2-like protein 3-interacting protein 1 (Endophilin- 3-interacting protein).

PLEC1_HUMAN
NC score	0.024671 (rank : 37)	θ value	0.0961366 (rank : 8)
Query Neighborhood Hits	41	Target Neighborhood Hits	1326	Shared Neighborhood Hits	12
SwissProt Accessions	Q15149, Q15148, Q16640	Gene names	PLEC1
Domain Architecture
Description	Plectin-1 (PLTN) (PCN) (Hemidesmosomal protein 1) (HD1).

LRC27_HUMAN
NC score	0.018268 (rank : 38)	θ value	8.99809 (rank : 40)
Query Neighborhood Hits	41	Target Neighborhood Hits	710	Shared Neighborhood Hits	11
SwissProt Accessions	Q9C0I9, Q5SZH6, Q5SZH8, Q5SZH9, Q86XT5, Q8N7C8, Q8NA21	Gene names	LRRC27, KIAA1674
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 27.

MAP2_MOUSE
NC score	0.013841 (rank : 39)	θ value	6.88961 (rank : 29)
Query Neighborhood Hits	41	Target Neighborhood Hits	342	Shared Neighborhood Hits	5
SwissProt Accessions	P20357	Gene names	Map2, Mtap2
Domain Architecture
Description	Microtubule-associated protein 2 (MAP 2).

SOX5_HUMAN
NC score	0.012537 (rank : 40)	θ value	6.88961 (rank : 31)
Query Neighborhood Hits	41	Target Neighborhood Hits	219	Shared Neighborhood Hits	3
SwissProt Accessions	P35711, Q86UK8, Q8J017, Q8J018, Q8J019, Q8J020, Q8N1D9, Q8N7E0, Q8TEA4	Gene names	SOX5
Domain Architecture
Description	Transcription factor SOX-5.

KI21A_HUMAN
NC score	0.010397 (rank : 41)	θ value	5.27518 (rank : 26)
Query Neighborhood Hits	41	Target Neighborhood Hits	1543	Shared Neighborhood Hits	14
SwissProt Accessions	Q7Z4S6, Q6UKL9, Q7Z668, Q86WZ5, Q8IVZ8, Q9C0F5, Q9NXU4, Q9Y590	Gene names	KIF21A, KIAA1708, KIF2
Domain Architecture	No domain graphic available
Description	Kinesin family member 21A (Kinesin-like protein KIF2) (NY-REN-62 antigen).

FREM1_HUMAN
NC score	0.010386 (rank : 42)	θ value	8.99809 (rank : 38)
Query Neighborhood Hits	41	Target Neighborhood Hits	170	Shared Neighborhood Hits	3
SwissProt Accessions	Q5H8C1, Q5VV00, Q5VV01, Q6MZI4, Q8NEG9, Q96LI3	Gene names	FREM1, C9orf154
Domain Architecture	No domain graphic available
Description	FRAS1-related extracellular matrix protein 1 precursor (Protein QBRICK).

PP16A_HUMAN
NC score	0.009012 (rank : 43)	θ value	6.88961 (rank : 30)
Query Neighborhood Hits	41	Target Neighborhood Hits	340	Shared Neighborhood Hits	3
SwissProt Accessions	Q96I34	Gene names	PPP1R16A, MYPT3
Domain Architecture
Description	Protein phosphatase 1 regulatory subunit 16A (Myosin phosphatase- targeting subunit 3).

TRHY_HUMAN
NC score	0.007565 (rank : 44)	θ value	6.88961 (rank : 32)
Query Neighborhood Hits	41	Target Neighborhood Hits	1385	Shared Neighborhood Hits	11
SwissProt Accessions	Q07283	Gene names	THH, THL, TRHY
Domain Architecture
Description	Trichohyalin.

DESM_HUMAN
NC score	0.005765 (rank : 45)	θ value	8.99809 (rank : 37)
Query Neighborhood Hits	41	Target Neighborhood Hits	495	Shared Neighborhood Hits	5
SwissProt Accessions	P17661, Q15787, Q8IZR1, Q8IZR6, Q8NES2, Q8NEU6, Q8TAC4, Q8TCX2, Q8TD99, Q9UHN5, Q9UJ80	Gene names	DES
Domain Architecture
Description	Desmin.

CD2L1_HUMAN
NC score	0.002919 (rank : 46)	θ value	8.99809 (rank : 35)
Query Neighborhood Hits	41	Target Neighborhood Hits	1467	Shared Neighborhood Hits	10
SwissProt Accessions	P21127, O95265, Q12817, Q12818, Q12819, Q12820, Q12822, Q8N530, Q9NZS5, Q9UBJ0, Q9UBQ1, Q9UBR0, Q9UNY2, Q9UP57, Q9UP58, Q9UP59	Gene names	CDC2L1, PITSLREA, PK58
Domain Architecture
Description	PITSLRE serine/threonine-protein kinase CDC2L1 (EC 2.7.11.22) (Galactosyltransferase-associated protein kinase p58/GTA) (Cell division cycle 2-like protein kinase 1) (CLK-1) (CDK11) (p58 CLK-1).

CD2L2_HUMAN
NC score	0.002917 (rank : 47)	θ value	8.99809 (rank : 36)
Query Neighborhood Hits	41	Target Neighborhood Hits	1439	Shared Neighborhood Hits	10
SwissProt Accessions	Q9UQ88, O95227, O95228, O96012, Q12821, Q12853, Q12854, Q5QPR0, Q5QPR1, Q5QPR2, Q9UBC4, Q9UBI3, Q9UEI1, Q9UEI2, Q9UP53, Q9UP54, Q9UP55, Q9UP56, Q9UQ86, Q9UQ87, Q9UQ89	Gene names	CDC2L2, PITSLREB
Domain Architecture
Description	PITSLRE serine/threonine-protein kinase CDC2L2 (EC 2.7.11.22) (Galactosyltransferase-associated protein kinase p58/GTA) (Cell division cycle 2-like protein kinase 2) (CDK11).