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Network neighborhood for query Sequence : AP1M1_HUMAN

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AP1M1_HUMAN
SwissProt Accessions	Q9BXS5	Gene names	AP1M1, CLTNM
Domain Architecture
Description	AP-1 complex subunit mu-1 (Adaptor-related protein complex 1 mu-1 subunit) (Mu-adaptin 1) (Adaptor protein complex AP-1 mu-1 subunit) (Golgi adaptor HA1/AP1 adaptin mu-1 subunit) (Clathrin assembly protein assembly protein complex 1 medium chain 1) (AP-mu chain family member mu1A) (Clathrin coat assembly protein AP47) (Clathrin coat- associated protein AP47).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

AP1M1_HUMAN
θ value	0 (rank : 1)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	34	Target Neighborhood Hits	34	Shared Neighborhood Hits	34
SwissProt Accessions	Q9BXS5	Gene names	AP1M1, CLTNM
Domain Architecture
Description	AP-1 complex subunit mu-1 (Adaptor-related protein complex 1 mu-1 subunit) (Mu-adaptin 1) (Adaptor protein complex AP-1 mu-1 subunit) (Golgi adaptor HA1/AP1 adaptin mu-1 subunit) (Clathrin assembly protein assembly protein complex 1 medium chain 1) (AP-mu chain family member mu1A) (Clathrin coat assembly protein AP47) (Clathrin coat- associated protein AP47).

AP1M1_MOUSE
θ value	0 (rank : 2)	NC score	0.999949 (rank : 2)
Query Neighborhood Hits	34	Target Neighborhood Hits	34	Shared Neighborhood Hits	34
SwissProt Accessions	P35585	Gene names	Ap1m1, Cltnm
Domain Architecture
Description	AP-1 complex subunit mu-1 (Adaptor-related protein complex 1 mu-1 subunit) (Mu-adaptin 1) (Adaptor protein complex AP-1 mu-1 subunit) (Golgi adaptor HA1/AP1 adaptin mu-1 subunit) (Clathrin assembly protein assembly protein complex 1 medium chain 1) (AP-mu chain family member mu1A) (Clathrin coat assembly protein AP47) (Clathrin coat- associated protein AP47).

AP1M2_HUMAN
θ value	0 (rank : 3)	NC score	0.996204 (rank : 4)
Query Neighborhood Hits	34	Target Neighborhood Hits	36	Shared Neighborhood Hits	29
SwissProt Accessions	Q9Y6Q5, Q9BSI8	Gene names	AP1M2
Domain Architecture
Description	AP-1 complex subunit mu-2 (Adaptor-related protein complex 1 mu-2 subunit) (Mu-adaptin 2) (Adaptor protein complex AP-1 mu-2 subunit) (Golgi adaptor HA1/AP1 adaptin mu-2 subunit) (Clathrin assembly protein assembly protein complex 1 medium chain 2) (AP-mu chain family member mu1B).

AP1M2_MOUSE
θ value	0 (rank : 4)	NC score	0.997133 (rank : 3)
Query Neighborhood Hits	34	Target Neighborhood Hits	34	Shared Neighborhood Hits	29
SwissProt Accessions	Q9WVP1, Q99LA4, Q9CWP7	Gene names	Ap1m2
Domain Architecture
Description	AP-1 complex subunit mu-2 (Adaptor-related protein complex 1 mu-2 subunit) (Mu-adaptin 2) (Adaptor protein complex AP-1 mu-2 subunit) (Golgi adaptor HA1/AP1 adaptin mu-2 subunit) (Clathrin assembly protein assembly protein complex 1 medium chain 2) (AP-mu chain family member mu1B).

AP2M1_HUMAN
θ value	7.17548e-90 (rank : 5)	NC score	0.965323 (rank : 5)
Query Neighborhood Hits	34	Target Neighborhood Hits	33	Shared Neighborhood Hits	27
SwissProt Accessions	Q96CW1, P20172, P53679	Gene names	AP2M1, CLAPM1, KIAA0109
Domain Architecture	No domain graphic available
Description	AP-2 complex subunit mu-1 (Adaptin mu-1) (AP-2 mu-2 chain) (Clathrin coat assembly protein AP50) (Clathrin coat-associated protein AP50) (Plasma membrane adaptor AP-2 50 kDa protein) (HA2 50 kDa subunit) (Clathrin assembly protein complex 2 medium chain).

AP2M1_MOUSE
θ value	7.17548e-90 (rank : 6)	NC score	0.965323 (rank : 6)
Query Neighborhood Hits	34	Target Neighborhood Hits	33	Shared Neighborhood Hits	27
SwissProt Accessions	P84091, P20172, P53679	Gene names	Ap2m1, Clapm1
Domain Architecture	No domain graphic available
Description	AP-2 complex subunit mu-1 (Adaptin mu-1) (AP-2 mu-2 chain) (Clathrin coat assembly protein AP50) (Clathrin coat-associated protein AP50) (Plasma membrane adaptor AP-2 50 kDa protein) (Clathrin assembly protein complex 2 medium chain).

AP4M1_MOUSE
θ value	2.1121e-49 (rank : 7)	NC score	0.897684 (rank : 8)
Query Neighborhood Hits	34	Target Neighborhood Hits	23	Shared Neighborhood Hits	22
SwissProt Accessions	Q9JKC7	Gene names	Ap4m1
Domain Architecture
Description	AP-4 complex subunit mu-1 (Adapter-related protein complex 4 mu-1 subunit) (Mu subunit of AP-4) (AP-4 adapter complex mu subunit) (Mu- adaptin-related protein 2) (mu-ARP2) (mu4).

AP4M1_HUMAN
θ value	6.7944e-48 (rank : 8)	NC score	0.901000 (rank : 7)
Query Neighborhood Hits	34	Target Neighborhood Hits	27	Shared Neighborhood Hits	24
SwissProt Accessions	O00189, Q9UHK9	Gene names	AP4M1, MUARP2
Domain Architecture
Description	AP-4 complex subunit mu-1 (Adapter-related protein complex 4 mu-1 subunit) (Mu subunit of AP-4) (AP-4 adapter complex mu subunit) (Mu- adaptin-related protein 2) (mu-ARP2) (mu4).

AP3M1_HUMAN
θ value	7.51208e-47 (rank : 9)	NC score	0.859193 (rank : 9)
Query Neighborhood Hits	34	Target Neighborhood Hits	30	Shared Neighborhood Hits	23
SwissProt Accessions	Q9Y2T2	Gene names	AP3M1
Domain Architecture
Description	AP-3 complex subunit mu-1 (Adapter-related protein complex 3 mu-1 subunit) (Mu-adaptin 3A) (AP-3 adapter complex mu3A subunit).

AP3M1_MOUSE
θ value	9.81109e-47 (rank : 10)	NC score	0.858874 (rank : 10)
Query Neighborhood Hits	34	Target Neighborhood Hits	30	Shared Neighborhood Hits	23
SwissProt Accessions	Q9JKC8, Q5BKQ6	Gene names	Ap3m1
Domain Architecture
Description	AP-3 complex subunit mu-1 (Adapter-related protein complex 3 mu-1 subunit) (Mu-adaptin 3A) (AP-3 adapter complex mu3A subunit).

AP3M2_MOUSE
θ value	2.67181e-44 (rank : 11)	NC score	0.851347 (rank : 11)
Query Neighborhood Hits	34	Target Neighborhood Hits	30	Shared Neighborhood Hits	23
SwissProt Accessions	Q8R2R9, Q3UYJ3, Q923G7	Gene names	Ap3m2
Domain Architecture	No domain graphic available
Description	AP-3 complex subunit mu-2 (Adapter-related protein complex 3 mu-2 subunit) (Clathrin coat assembly protein AP47 homolog 2) (Clathrin coat-associated protein AP47 homolog 2) (Golgi adaptor AP-1 47 kDa protein homolog 2) (HA1 47 kDa subunit homolog 2) (Clathrin assembly protein assembly protein complex 1 medium chain homolog 2) (P47B) (m3B).

AP3M2_HUMAN
θ value	1.01529e-43 (rank : 12)	NC score	0.850516 (rank : 12)
Query Neighborhood Hits	34	Target Neighborhood Hits	32	Shared Neighborhood Hits	23
SwissProt Accessions	P53677	Gene names	AP3M2
Domain Architecture
Description	AP-3 complex subunit mu-2 (Adapter-related protein complex 3 mu-2 subunit) (Clathrin coat assembly protein AP47 homolog 2) (Clathrin coat-associated protein AP47 homolog 2) (Golgi adaptor AP-1 47 kDa protein homolog 2) (HA1 47 kDa subunit homolog 2) (Clathrin assembly protein assembly protein complex 1 medium chain homolog 2) (P47B).

STON2_HUMAN
θ value	1.42992e-13 (rank : 13)	NC score	0.460841 (rank : 15)
Query Neighborhood Hits	34	Target Neighborhood Hits	115	Shared Neighborhood Hits	11
SwissProt Accessions	Q8WXE9, Q6NT47, Q96RI7, Q96RU6	Gene names	STON2, STN2, STNB
Domain Architecture
Description	Stonin-2 (Stoned B).

STON1_HUMAN
θ value	7.09661e-13 (rank : 14)	NC score	0.471412 (rank : 14)
Query Neighborhood Hits	34	Target Neighborhood Hits	49	Shared Neighborhood Hits	16
SwissProt Accessions	Q9Y6Q2, Q96JE3, Q9BYX3	Gene names	STON1, SALF, SBLF, STN1
Domain Architecture
Description	Stonin-1 (Stoned B-like factor).

STON1_MOUSE
θ value	3.52202e-12 (rank : 15)	NC score	0.487438 (rank : 13)
Query Neighborhood Hits	34	Target Neighborhood Hits	50	Shared Neighborhood Hits	16
SwissProt Accessions	Q8CDJ8, Q8CDL8, Q9D5T3	Gene names	Ston1, Salf, Sblf, Stn1
Domain Architecture
Description	Stonin-1 (Stoned B-like factor).

STON2_MOUSE
θ value	2.98157e-11 (rank : 16)	NC score	0.450347 (rank : 16)
Query Neighborhood Hits	34	Target Neighborhood Hits	75	Shared Neighborhood Hits	11
SwissProt Accessions	Q8BZ60	Gene names	Ston2, Stn2, Stnb
Domain Architecture
Description	Stonin-2 (Stoned B).

CN108_HUMAN
θ value	0.00509761 (rank : 17)	NC score	0.164352 (rank : 19)
Query Neighborhood Hits	34	Target Neighborhood Hits	6	Shared Neighborhood Hits	6
SwissProt Accessions	Q9H0R1, O95354, Q96DX3, Q9NVC5	Gene names	C14orf108
Domain Architecture
Description	Protein C14orf108 (Putative HIV-1 infection-related protein).

COPD_HUMAN
θ value	0.00869519 (rank : 18)	NC score	0.189259 (rank : 17)
Query Neighborhood Hits	34	Target Neighborhood Hits	40	Shared Neighborhood Hits	17
SwissProt Accessions	P48444, Q52M80	Gene names	ARCN1, COPD
Domain Architecture
Description	Coatomer subunit delta (Delta-coat protein) (Delta-COP) (Archain).

COPD_MOUSE
θ value	0.00869519 (rank : 19)	NC score	0.189256 (rank : 18)
Query Neighborhood Hits	34	Target Neighborhood Hits	41	Shared Neighborhood Hits	17
SwissProt Accessions	Q5XJY5	Gene names	Arcn1, Copd
Domain Architecture	No domain graphic available
Description	Coatomer subunit delta (Delta-coat protein) (Delta-COP) (Archain).

CN108_MOUSE
θ value	0.47712 (rank : 20)	NC score	0.109905 (rank : 27)
Query Neighborhood Hits	34	Target Neighborhood Hits	11	Shared Neighborhood Hits	6
SwissProt Accessions	Q8BJ63, Q3TPT5, Q8BII2, Q8BJ31, Q8BJ58, Q8BY11, Q8R5B1	Gene names
Domain Architecture
Description	Protein C14orf108 homolog.

MINK1_MOUSE
θ value	1.06291 (rank : 21)	NC score	0.003246 (rank : 34)
Query Neighborhood Hits	34	Target Neighborhood Hits	1451	Shared Neighborhood Hits	4
SwissProt Accessions	Q9JM52, Q921M6, Q9JM92	Gene names	Mink1, Map4k6, Mink
Domain Architecture
Description	Misshapen-like kinase 1 (EC 2.7.11.1) (Mitogen-activated protein kinase kinase kinase kinase 6) (MAPK/ERK kinase kinase kinase 6) (MEK kinase kinase 6) (MEKKK 6) (Misshapen/NIK-related kinase) (GCK family kinase MiNK).

MINK1_HUMAN
θ value	1.38821 (rank : 22)	NC score	0.002956 (rank : 35)
Query Neighborhood Hits	34	Target Neighborhood Hits	1477	Shared Neighborhood Hits	4
SwissProt Accessions	Q8N4C8, Q9P1X1, Q9P2R8	Gene names	MINK1, MAP4K6, MINK
Domain Architecture
Description	Misshapen-like kinase 1 (EC 2.7.11.1) (Mitogen-activated protein kinase kinase kinase kinase 6) (MAPK/ERK kinase kinase kinase 6) (MEK kinase kinase 6) (MEKKK 6) (Misshapen/NIK-related kinase) (GCK family kinase MiNK).

AP1S3_HUMAN
θ value	1.81305 (rank : 23)	NC score	0.147236 (rank : 20)
Query Neighborhood Hits	34	Target Neighborhood Hits	30	Shared Neighborhood Hits	21
SwissProt Accessions	Q96PC3, Q8WTY1, Q96DD1	Gene names	AP1S3
Domain Architecture
Description	AP-1 complex subunit sigma-3 (Adapter-related protein complex 1 sigma- 1C subunit) (Sigma-adaptin 1C) (Adaptor protein complex AP-1 sigma-1C subunit) (Golgi adaptor HA1/AP1 adaptin sigma-1C subunit) (Clathrin assembly protein complex 1 sigma-1C small chain) (Sigma 1C subunit of AP-1 clathrin).

AP1S1_HUMAN
θ value	2.36792 (rank : 24)	NC score	0.128861 (rank : 25)
Query Neighborhood Hits	34	Target Neighborhood Hits	30	Shared Neighborhood Hits	23
SwissProt Accessions	P61966, P82267, Q00382, Q9BTN4, Q9UDW9	Gene names	AP1S1, AP19, CLAPS1
Domain Architecture
Description	AP-1 complex subunit sigma-1A (Adapter-related protein complex 1 sigma-1A subunit) (Sigma-adaptin 1A) (Adaptor protein complex AP-1 sigma-1A subunit) (Golgi adaptor HA1/AP1 adaptin sigma-1A subunit) (Clathrin assembly protein complex 1 sigma-1A small chain) (Clathrin coat assembly protein AP19) (HA1 19 kDa subunit) (Sigma 1a subunit of AP-1 clathrin).

AP1S1_MOUSE
θ value	2.36792 (rank : 25)	NC score	0.128861 (rank : 26)
Query Neighborhood Hits	34	Target Neighborhood Hits	30	Shared Neighborhood Hits	23
SwissProt Accessions	P61967, P82267, Q00382, Q9BTN4, Q9UDW9	Gene names	Ap1s1, Ap19
Domain Architecture
Description	AP-1 complex subunit sigma-1A (Adapter-related protein complex 1 sigma-1A subunit) (Sigma-adaptin 1A) (Adaptor protein complex AP-1 sigma-1A subunit) (Golgi adaptor HA1/AP1 adaptin sigma-1A subunit) (Clathrin assembly protein complex 1 sigma-1A small chain) (Clathrin coat assembly protein AP19) (HA1 19 kDa subunit) (Sigma 1a subunit of AP-1 clathrin).

AP1S2_HUMAN
θ value	3.0926 (rank : 26)	NC score	0.132832 (rank : 23)
Query Neighborhood Hits	34	Target Neighborhood Hits	31	Shared Neighborhood Hits	23
SwissProt Accessions	P56377, O95326, Q9H2N6	Gene names	AP1S2
Domain Architecture
Description	AP-1 complex subunit sigma-2 (Adapter-related protein complex 1 sigma- 1B subunit) (Sigma-adaptin 1B) (Adaptor protein complex AP-1 sigma-1B subunit) (Golgi adaptor HA1/AP1 adaptin sigma-1B subunit) (Clathrin assembly protein complex 1 sigma-1B small chain) (Sigma 1B subunit of AP-1 clathrin).

AP1S2_MOUSE
θ value	3.0926 (rank : 27)	NC score	0.136445 (rank : 22)
Query Neighborhood Hits	34	Target Neighborhood Hits	31	Shared Neighborhood Hits	23
SwissProt Accessions	Q9DB50, Q543R7	Gene names	Ap1s2
Domain Architecture
Description	AP-1 complex subunit sigma-2 (Adapter-related protein complex 1 sigma- 1B subunit) (Sigma-adaptin 1B) (Adaptor protein complex AP-1 sigma-1B subunit) (Golgi adaptor HA1/AP1 adaptin sigma-1B subunit) (Clathrin assembly protein complex 1 sigma-1B small chain) (Sigma 1B subunit of AP-1 clathrin).

AP4S1_HUMAN
θ value	3.0926 (rank : 28)	NC score	0.137579 (rank : 21)
Query Neighborhood Hits	34	Target Neighborhood Hits	29	Shared Neighborhood Hits	21
SwissProt Accessions	Q9Y587	Gene names	AP4S1
Domain Architecture
Description	AP-4 complex subunit sigma-1 (Adapter-related protein complex 4 sigma- 1 subunit) (Sigma subunit of AP-4) (AP-4 adapter complex sigma subunit).

MLRV_MOUSE
θ value	3.0926 (rank : 29)	NC score	0.015294 (rank : 32)
Query Neighborhood Hits	34	Target Neighborhood Hits	89	Shared Neighborhood Hits	4
SwissProt Accessions	P51667	Gene names	Myl2, Mylpc
Domain Architecture
Description	Myosin regulatory light chain 2, ventricular/cardiac muscle isoform (MLC-2) (MLC-2v).

AP1S3_MOUSE
θ value	4.03905 (rank : 30)	NC score	0.130630 (rank : 24)
Query Neighborhood Hits	34	Target Neighborhood Hits	30	Shared Neighborhood Hits	21
SwissProt Accessions	Q7TN05	Gene names	Ap1s3
Domain Architecture	No domain graphic available
Description	AP-1 complex subunit sigma-3 (Adapter-related protein complex 1 sigma- 1C subunit) (Sigma-adaptin 1C) (Adaptor protein complex AP-1 sigma-1C subunit) (Golgi adaptor HA1/AP1 adaptin sigma-1C subunit) (Clathrin assembly protein complex 1 sigma-1C small chain) (Sigma 1C subunit of AP-1 clathrin).

AP2S1_HUMAN
θ value	4.03905 (rank : 31)	NC score	0.103944 (rank : 29)
Query Neighborhood Hits	34	Target Neighborhood Hits	26	Shared Neighborhood Hits	21
SwissProt Accessions	P53680, O75977, Q6PK67	Gene names	AP2S1, AP17, CLAPS2
Domain Architecture
Description	AP-2 complex subunit sigma-1 (Adapter-related protein complex 2 sigma- 1 subunit) (Clathrin coat assembly protein AP17) (Clathrin coat- associated protein AP17) (Plasma membrane adaptor AP-2 17 kDa protein) (HA2 17 kDa subunit) (Clathrin assembly protein 2 small chain).

AP2S1_MOUSE
θ value	4.03905 (rank : 32)	NC score	0.103944 (rank : 30)
Query Neighborhood Hits	34	Target Neighborhood Hits	26	Shared Neighborhood Hits	21
SwissProt Accessions	P62743, P70626, P97626, Q00380	Gene names	Ap2s1, Ap17, Claps2
Domain Architecture	No domain graphic available
Description	AP-2 complex subunit sigma-1 (Adapter-related protein complex 2 sigma- 1 subunit) (Sigma-adaptin 3b) (Clathrin coat assembly protein AP17) (Clathrin coat-associated protein AP17) (Plasma membrane adaptor AP-2 17 kDa protein) (Clathrin assembly protein 2 small chain).

MLRV_HUMAN
θ value	5.27518 (rank : 33)	NC score	0.012908 (rank : 33)
Query Neighborhood Hits	34	Target Neighborhood Hits	89	Shared Neighborhood Hits	4
SwissProt Accessions	P10916, Q16123	Gene names	MYL2
Domain Architecture
Description	Myosin regulatory light chain 2, ventricular/cardiac muscle isoform (MLC-2) (MLC-2v).

SGOL2_HUMAN
θ value	5.27518 (rank : 34)	NC score	0.015633 (rank : 31)
Query Neighborhood Hits	34	Target Neighborhood Hits	207	Shared Neighborhood Hits	3
SwissProt Accessions	Q562F6, Q53RR9, Q53T20, Q86XY4, Q8IWK2, Q8IZK1, Q8N1Q5, Q96LQ3	Gene names	SGOL2
Domain Architecture	No domain graphic available
Description	Shugoshin-like 2 (Tripin).

AP4S1_MOUSE
θ value	θ > 10 (rank : 35)	NC score	0.108811 (rank : 28)
Query Neighborhood Hits	34	Target Neighborhood Hits	26	Shared Neighborhood Hits	19
SwissProt Accessions	Q9WVL1	Gene names	Ap4s1
Domain Architecture
Description	AP-4 complex subunit sigma-1 (Adapter-related protein complex 4 sigma- 1 subunit) (Sigma subunit of AP-4) (AP-4 adapter complex sigma subunit).

Hits sorted by NC score

AP1M1_HUMAN
NC score	0.999962 (rank : 1)	θ value	0 (rank : 1)
Query Neighborhood Hits	34	Target Neighborhood Hits	34	Shared Neighborhood Hits	34
SwissProt Accessions	Q9BXS5	Gene names	AP1M1, CLTNM
Domain Architecture
Description	AP-1 complex subunit mu-1 (Adaptor-related protein complex 1 mu-1 subunit) (Mu-adaptin 1) (Adaptor protein complex AP-1 mu-1 subunit) (Golgi adaptor HA1/AP1 adaptin mu-1 subunit) (Clathrin assembly protein assembly protein complex 1 medium chain 1) (AP-mu chain family member mu1A) (Clathrin coat assembly protein AP47) (Clathrin coat- associated protein AP47).

AP1M1_MOUSE
NC score	0.999949 (rank : 2)	θ value	0 (rank : 2)
Query Neighborhood Hits	34	Target Neighborhood Hits	34	Shared Neighborhood Hits	34
SwissProt Accessions	P35585	Gene names	Ap1m1, Cltnm
Domain Architecture
Description	AP-1 complex subunit mu-1 (Adaptor-related protein complex 1 mu-1 subunit) (Mu-adaptin 1) (Adaptor protein complex AP-1 mu-1 subunit) (Golgi adaptor HA1/AP1 adaptin mu-1 subunit) (Clathrin assembly protein assembly protein complex 1 medium chain 1) (AP-mu chain family member mu1A) (Clathrin coat assembly protein AP47) (Clathrin coat- associated protein AP47).

AP1M2_MOUSE
NC score	0.997133 (rank : 3)	θ value	0 (rank : 4)
Query Neighborhood Hits	34	Target Neighborhood Hits	34	Shared Neighborhood Hits	29
SwissProt Accessions	Q9WVP1, Q99LA4, Q9CWP7	Gene names	Ap1m2
Domain Architecture
Description	AP-1 complex subunit mu-2 (Adaptor-related protein complex 1 mu-2 subunit) (Mu-adaptin 2) (Adaptor protein complex AP-1 mu-2 subunit) (Golgi adaptor HA1/AP1 adaptin mu-2 subunit) (Clathrin assembly protein assembly protein complex 1 medium chain 2) (AP-mu chain family member mu1B).

AP1M2_HUMAN
NC score	0.996204 (rank : 4)	θ value	0 (rank : 3)
Query Neighborhood Hits	34	Target Neighborhood Hits	36	Shared Neighborhood Hits	29
SwissProt Accessions	Q9Y6Q5, Q9BSI8	Gene names	AP1M2
Domain Architecture
Description	AP-1 complex subunit mu-2 (Adaptor-related protein complex 1 mu-2 subunit) (Mu-adaptin 2) (Adaptor protein complex AP-1 mu-2 subunit) (Golgi adaptor HA1/AP1 adaptin mu-2 subunit) (Clathrin assembly protein assembly protein complex 1 medium chain 2) (AP-mu chain family member mu1B).

AP2M1_HUMAN
NC score	0.965323 (rank : 5)	θ value	7.17548e-90 (rank : 5)
Query Neighborhood Hits	34	Target Neighborhood Hits	33	Shared Neighborhood Hits	27
SwissProt Accessions	Q96CW1, P20172, P53679	Gene names	AP2M1, CLAPM1, KIAA0109
Domain Architecture	No domain graphic available
Description	AP-2 complex subunit mu-1 (Adaptin mu-1) (AP-2 mu-2 chain) (Clathrin coat assembly protein AP50) (Clathrin coat-associated protein AP50) (Plasma membrane adaptor AP-2 50 kDa protein) (HA2 50 kDa subunit) (Clathrin assembly protein complex 2 medium chain).

AP2M1_MOUSE
NC score	0.965323 (rank : 6)	θ value	7.17548e-90 (rank : 6)
Query Neighborhood Hits	34	Target Neighborhood Hits	33	Shared Neighborhood Hits	27
SwissProt Accessions	P84091, P20172, P53679	Gene names	Ap2m1, Clapm1
Domain Architecture	No domain graphic available
Description	AP-2 complex subunit mu-1 (Adaptin mu-1) (AP-2 mu-2 chain) (Clathrin coat assembly protein AP50) (Clathrin coat-associated protein AP50) (Plasma membrane adaptor AP-2 50 kDa protein) (Clathrin assembly protein complex 2 medium chain).

AP4M1_HUMAN
NC score	0.901000 (rank : 7)	θ value	6.7944e-48 (rank : 8)
Query Neighborhood Hits	34	Target Neighborhood Hits	27	Shared Neighborhood Hits	24
SwissProt Accessions	O00189, Q9UHK9	Gene names	AP4M1, MUARP2
Domain Architecture
Description	AP-4 complex subunit mu-1 (Adapter-related protein complex 4 mu-1 subunit) (Mu subunit of AP-4) (AP-4 adapter complex mu subunit) (Mu- adaptin-related protein 2) (mu-ARP2) (mu4).

AP4M1_MOUSE
NC score	0.897684 (rank : 8)	θ value	2.1121e-49 (rank : 7)
Query Neighborhood Hits	34	Target Neighborhood Hits	23	Shared Neighborhood Hits	22
SwissProt Accessions	Q9JKC7	Gene names	Ap4m1
Domain Architecture
Description	AP-4 complex subunit mu-1 (Adapter-related protein complex 4 mu-1 subunit) (Mu subunit of AP-4) (AP-4 adapter complex mu subunit) (Mu- adaptin-related protein 2) (mu-ARP2) (mu4).

AP3M1_HUMAN
NC score	0.859193 (rank : 9)	θ value	7.51208e-47 (rank : 9)
Query Neighborhood Hits	34	Target Neighborhood Hits	30	Shared Neighborhood Hits	23
SwissProt Accessions	Q9Y2T2	Gene names	AP3M1
Domain Architecture
Description	AP-3 complex subunit mu-1 (Adapter-related protein complex 3 mu-1 subunit) (Mu-adaptin 3A) (AP-3 adapter complex mu3A subunit).

AP3M1_MOUSE
NC score	0.858874 (rank : 10)	θ value	9.81109e-47 (rank : 10)
Query Neighborhood Hits	34	Target Neighborhood Hits	30	Shared Neighborhood Hits	23
SwissProt Accessions	Q9JKC8, Q5BKQ6	Gene names	Ap3m1
Domain Architecture
Description	AP-3 complex subunit mu-1 (Adapter-related protein complex 3 mu-1 subunit) (Mu-adaptin 3A) (AP-3 adapter complex mu3A subunit).

AP3M2_MOUSE
NC score	0.851347 (rank : 11)	θ value	2.67181e-44 (rank : 11)
Query Neighborhood Hits	34	Target Neighborhood Hits	30	Shared Neighborhood Hits	23
SwissProt Accessions	Q8R2R9, Q3UYJ3, Q923G7	Gene names	Ap3m2
Domain Architecture	No domain graphic available
Description	AP-3 complex subunit mu-2 (Adapter-related protein complex 3 mu-2 subunit) (Clathrin coat assembly protein AP47 homolog 2) (Clathrin coat-associated protein AP47 homolog 2) (Golgi adaptor AP-1 47 kDa protein homolog 2) (HA1 47 kDa subunit homolog 2) (Clathrin assembly protein assembly protein complex 1 medium chain homolog 2) (P47B) (m3B).

AP3M2_HUMAN
NC score	0.850516 (rank : 12)	θ value	1.01529e-43 (rank : 12)
Query Neighborhood Hits	34	Target Neighborhood Hits	32	Shared Neighborhood Hits	23
SwissProt Accessions	P53677	Gene names	AP3M2
Domain Architecture
Description	AP-3 complex subunit mu-2 (Adapter-related protein complex 3 mu-2 subunit) (Clathrin coat assembly protein AP47 homolog 2) (Clathrin coat-associated protein AP47 homolog 2) (Golgi adaptor AP-1 47 kDa protein homolog 2) (HA1 47 kDa subunit homolog 2) (Clathrin assembly protein assembly protein complex 1 medium chain homolog 2) (P47B).

STON1_MOUSE
NC score	0.487438 (rank : 13)	θ value	3.52202e-12 (rank : 15)
Query Neighborhood Hits	34	Target Neighborhood Hits	50	Shared Neighborhood Hits	16
SwissProt Accessions	Q8CDJ8, Q8CDL8, Q9D5T3	Gene names	Ston1, Salf, Sblf, Stn1
Domain Architecture
Description	Stonin-1 (Stoned B-like factor).

STON1_HUMAN
NC score	0.471412 (rank : 14)	θ value	7.09661e-13 (rank : 14)
Query Neighborhood Hits	34	Target Neighborhood Hits	49	Shared Neighborhood Hits	16
SwissProt Accessions	Q9Y6Q2, Q96JE3, Q9BYX3	Gene names	STON1, SALF, SBLF, STN1
Domain Architecture
Description	Stonin-1 (Stoned B-like factor).

STON2_HUMAN
NC score	0.460841 (rank : 15)	θ value	1.42992e-13 (rank : 13)
Query Neighborhood Hits	34	Target Neighborhood Hits	115	Shared Neighborhood Hits	11
SwissProt Accessions	Q8WXE9, Q6NT47, Q96RI7, Q96RU6	Gene names	STON2, STN2, STNB
Domain Architecture
Description	Stonin-2 (Stoned B).

STON2_MOUSE
NC score	0.450347 (rank : 16)	θ value	2.98157e-11 (rank : 16)
Query Neighborhood Hits	34	Target Neighborhood Hits	75	Shared Neighborhood Hits	11
SwissProt Accessions	Q8BZ60	Gene names	Ston2, Stn2, Stnb
Domain Architecture
Description	Stonin-2 (Stoned B).

COPD_HUMAN
NC score	0.189259 (rank : 17)	θ value	0.00869519 (rank : 18)
Query Neighborhood Hits	34	Target Neighborhood Hits	40	Shared Neighborhood Hits	17
SwissProt Accessions	P48444, Q52M80	Gene names	ARCN1, COPD
Domain Architecture
Description	Coatomer subunit delta (Delta-coat protein) (Delta-COP) (Archain).

COPD_MOUSE
NC score	0.189256 (rank : 18)	θ value	0.00869519 (rank : 19)
Query Neighborhood Hits	34	Target Neighborhood Hits	41	Shared Neighborhood Hits	17
SwissProt Accessions	Q5XJY5	Gene names	Arcn1, Copd
Domain Architecture	No domain graphic available
Description	Coatomer subunit delta (Delta-coat protein) (Delta-COP) (Archain).

CN108_HUMAN
NC score	0.164352 (rank : 19)	θ value	0.00509761 (rank : 17)
Query Neighborhood Hits	34	Target Neighborhood Hits	6	Shared Neighborhood Hits	6
SwissProt Accessions	Q9H0R1, O95354, Q96DX3, Q9NVC5	Gene names	C14orf108
Domain Architecture
Description	Protein C14orf108 (Putative HIV-1 infection-related protein).

AP1S3_HUMAN
NC score	0.147236 (rank : 20)	θ value	1.81305 (rank : 23)
Query Neighborhood Hits	34	Target Neighborhood Hits	30	Shared Neighborhood Hits	21
SwissProt Accessions	Q96PC3, Q8WTY1, Q96DD1	Gene names	AP1S3
Domain Architecture
Description	AP-1 complex subunit sigma-3 (Adapter-related protein complex 1 sigma- 1C subunit) (Sigma-adaptin 1C) (Adaptor protein complex AP-1 sigma-1C subunit) (Golgi adaptor HA1/AP1 adaptin sigma-1C subunit) (Clathrin assembly protein complex 1 sigma-1C small chain) (Sigma 1C subunit of AP-1 clathrin).

AP4S1_HUMAN
NC score	0.137579 (rank : 21)	θ value	3.0926 (rank : 28)
Query Neighborhood Hits	34	Target Neighborhood Hits	29	Shared Neighborhood Hits	21
SwissProt Accessions	Q9Y587	Gene names	AP4S1
Domain Architecture
Description	AP-4 complex subunit sigma-1 (Adapter-related protein complex 4 sigma- 1 subunit) (Sigma subunit of AP-4) (AP-4 adapter complex sigma subunit).

AP1S2_MOUSE
NC score	0.136445 (rank : 22)	θ value	3.0926 (rank : 27)
Query Neighborhood Hits	34	Target Neighborhood Hits	31	Shared Neighborhood Hits	23
SwissProt Accessions	Q9DB50, Q543R7	Gene names	Ap1s2
Domain Architecture
Description	AP-1 complex subunit sigma-2 (Adapter-related protein complex 1 sigma- 1B subunit) (Sigma-adaptin 1B) (Adaptor protein complex AP-1 sigma-1B subunit) (Golgi adaptor HA1/AP1 adaptin sigma-1B subunit) (Clathrin assembly protein complex 1 sigma-1B small chain) (Sigma 1B subunit of AP-1 clathrin).

AP1S2_HUMAN
NC score	0.132832 (rank : 23)	θ value	3.0926 (rank : 26)
Query Neighborhood Hits	34	Target Neighborhood Hits	31	Shared Neighborhood Hits	23
SwissProt Accessions	P56377, O95326, Q9H2N6	Gene names	AP1S2
Domain Architecture
Description	AP-1 complex subunit sigma-2 (Adapter-related protein complex 1 sigma- 1B subunit) (Sigma-adaptin 1B) (Adaptor protein complex AP-1 sigma-1B subunit) (Golgi adaptor HA1/AP1 adaptin sigma-1B subunit) (Clathrin assembly protein complex 1 sigma-1B small chain) (Sigma 1B subunit of AP-1 clathrin).

AP1S3_MOUSE
NC score	0.130630 (rank : 24)	θ value	4.03905 (rank : 30)
Query Neighborhood Hits	34	Target Neighborhood Hits	30	Shared Neighborhood Hits	21
SwissProt Accessions	Q7TN05	Gene names	Ap1s3
Domain Architecture	No domain graphic available
Description	AP-1 complex subunit sigma-3 (Adapter-related protein complex 1 sigma- 1C subunit) (Sigma-adaptin 1C) (Adaptor protein complex AP-1 sigma-1C subunit) (Golgi adaptor HA1/AP1 adaptin sigma-1C subunit) (Clathrin assembly protein complex 1 sigma-1C small chain) (Sigma 1C subunit of AP-1 clathrin).

AP1S1_HUMAN
NC score	0.128861 (rank : 25)	θ value	2.36792 (rank : 24)
Query Neighborhood Hits	34	Target Neighborhood Hits	30	Shared Neighborhood Hits	23
SwissProt Accessions	P61966, P82267, Q00382, Q9BTN4, Q9UDW9	Gene names	AP1S1, AP19, CLAPS1
Domain Architecture
Description	AP-1 complex subunit sigma-1A (Adapter-related protein complex 1 sigma-1A subunit) (Sigma-adaptin 1A) (Adaptor protein complex AP-1 sigma-1A subunit) (Golgi adaptor HA1/AP1 adaptin sigma-1A subunit) (Clathrin assembly protein complex 1 sigma-1A small chain) (Clathrin coat assembly protein AP19) (HA1 19 kDa subunit) (Sigma 1a subunit of AP-1 clathrin).

AP1S1_MOUSE
NC score	0.128861 (rank : 26)	θ value	2.36792 (rank : 25)
Query Neighborhood Hits	34	Target Neighborhood Hits	30	Shared Neighborhood Hits	23
SwissProt Accessions	P61967, P82267, Q00382, Q9BTN4, Q9UDW9	Gene names	Ap1s1, Ap19
Domain Architecture
Description	AP-1 complex subunit sigma-1A (Adapter-related protein complex 1 sigma-1A subunit) (Sigma-adaptin 1A) (Adaptor protein complex AP-1 sigma-1A subunit) (Golgi adaptor HA1/AP1 adaptin sigma-1A subunit) (Clathrin assembly protein complex 1 sigma-1A small chain) (Clathrin coat assembly protein AP19) (HA1 19 kDa subunit) (Sigma 1a subunit of AP-1 clathrin).

CN108_MOUSE
NC score	0.109905 (rank : 27)	θ value	0.47712 (rank : 20)
Query Neighborhood Hits	34	Target Neighborhood Hits	11	Shared Neighborhood Hits	6
SwissProt Accessions	Q8BJ63, Q3TPT5, Q8BII2, Q8BJ31, Q8BJ58, Q8BY11, Q8R5B1	Gene names
Domain Architecture
Description	Protein C14orf108 homolog.

AP4S1_MOUSE
NC score	0.108811 (rank : 28)	θ value	θ > 10 (rank : 35)
Query Neighborhood Hits	34	Target Neighborhood Hits	26	Shared Neighborhood Hits	19
SwissProt Accessions	Q9WVL1	Gene names	Ap4s1
Domain Architecture
Description	AP-4 complex subunit sigma-1 (Adapter-related protein complex 4 sigma- 1 subunit) (Sigma subunit of AP-4) (AP-4 adapter complex sigma subunit).

AP2S1_HUMAN
NC score	0.103944 (rank : 29)	θ value	4.03905 (rank : 31)
Query Neighborhood Hits	34	Target Neighborhood Hits	26	Shared Neighborhood Hits	21
SwissProt Accessions	P53680, O75977, Q6PK67	Gene names	AP2S1, AP17, CLAPS2
Domain Architecture
Description	AP-2 complex subunit sigma-1 (Adapter-related protein complex 2 sigma- 1 subunit) (Clathrin coat assembly protein AP17) (Clathrin coat- associated protein AP17) (Plasma membrane adaptor AP-2 17 kDa protein) (HA2 17 kDa subunit) (Clathrin assembly protein 2 small chain).

AP2S1_MOUSE
NC score	0.103944 (rank : 30)	θ value	4.03905 (rank : 32)
Query Neighborhood Hits	34	Target Neighborhood Hits	26	Shared Neighborhood Hits	21
SwissProt Accessions	P62743, P70626, P97626, Q00380	Gene names	Ap2s1, Ap17, Claps2
Domain Architecture	No domain graphic available
Description	AP-2 complex subunit sigma-1 (Adapter-related protein complex 2 sigma- 1 subunit) (Sigma-adaptin 3b) (Clathrin coat assembly protein AP17) (Clathrin coat-associated protein AP17) (Plasma membrane adaptor AP-2 17 kDa protein) (Clathrin assembly protein 2 small chain).

SGOL2_HUMAN
NC score	0.015633 (rank : 31)	θ value	5.27518 (rank : 34)
Query Neighborhood Hits	34	Target Neighborhood Hits	207	Shared Neighborhood Hits	3
SwissProt Accessions	Q562F6, Q53RR9, Q53T20, Q86XY4, Q8IWK2, Q8IZK1, Q8N1Q5, Q96LQ3	Gene names	SGOL2
Domain Architecture	No domain graphic available
Description	Shugoshin-like 2 (Tripin).

MLRV_MOUSE
NC score	0.015294 (rank : 32)	θ value	3.0926 (rank : 29)
Query Neighborhood Hits	34	Target Neighborhood Hits	89	Shared Neighborhood Hits	4
SwissProt Accessions	P51667	Gene names	Myl2, Mylpc
Domain Architecture
Description	Myosin regulatory light chain 2, ventricular/cardiac muscle isoform (MLC-2) (MLC-2v).

MLRV_HUMAN
NC score	0.012908 (rank : 33)	θ value	5.27518 (rank : 33)
Query Neighborhood Hits	34	Target Neighborhood Hits	89	Shared Neighborhood Hits	4
SwissProt Accessions	P10916, Q16123	Gene names	MYL2
Domain Architecture
Description	Myosin regulatory light chain 2, ventricular/cardiac muscle isoform (MLC-2) (MLC-2v).

MINK1_MOUSE
NC score	0.003246 (rank : 34)	θ value	1.06291 (rank : 21)
Query Neighborhood Hits	34	Target Neighborhood Hits	1451	Shared Neighborhood Hits	4
SwissProt Accessions	Q9JM52, Q921M6, Q9JM92	Gene names	Mink1, Map4k6, Mink
Domain Architecture
Description	Misshapen-like kinase 1 (EC 2.7.11.1) (Mitogen-activated protein kinase kinase kinase kinase 6) (MAPK/ERK kinase kinase kinase 6) (MEK kinase kinase 6) (MEKKK 6) (Misshapen/NIK-related kinase) (GCK family kinase MiNK).

MINK1_HUMAN
NC score	0.002956 (rank : 35)	θ value	1.38821 (rank : 22)
Query Neighborhood Hits	34	Target Neighborhood Hits	1477	Shared Neighborhood Hits	4
SwissProt Accessions	Q8N4C8, Q9P1X1, Q9P2R8	Gene names	MINK1, MAP4K6, MINK
Domain Architecture
Description	Misshapen-like kinase 1 (EC 2.7.11.1) (Mitogen-activated protein kinase kinase kinase kinase 6) (MAPK/ERK kinase kinase kinase 6) (MEK kinase kinase 6) (MEKKK 6) (Misshapen/NIK-related kinase) (GCK family kinase MiNK).