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Network neighborhood for query Sequence : ECHA_HUMAN

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ECHA_HUMAN
SwissProt Accessions	P40939, Q16679, Q96GT7	Gene names	HADHA, HADH
Domain Architecture
Description	Trifunctional enzyme subunit alpha, mitochondrial precursor (TP-alpha) (78 kDa gastrin-binding protein) [Includes: Long-chain enoyl-CoA hydratase (EC 4.2.1.17); Long chain 3-hydroxyacyl-CoA dehydrogenase (EC 1.1.1.211)].
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

ECHA_HUMAN
θ value	0 (rank : 1)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	28	Target Neighborhood Hits	28	Shared Neighborhood Hits	28
SwissProt Accessions	P40939, Q16679, Q96GT7	Gene names	HADHA, HADH
Domain Architecture
Description	Trifunctional enzyme subunit alpha, mitochondrial precursor (TP-alpha) (78 kDa gastrin-binding protein) [Includes: Long-chain enoyl-CoA hydratase (EC 4.2.1.17); Long chain 3-hydroxyacyl-CoA dehydrogenase (EC 1.1.1.211)].

ECHP_HUMAN
θ value	1.50314e-71 (rank : 2)	NC score	0.909260 (rank : 3)
Query Neighborhood Hits	28	Target Neighborhood Hits	28	Shared Neighborhood Hits	19
SwissProt Accessions	Q08426	Gene names	EHHADH, ECHD
Domain Architecture
Description	Peroxisomal bifunctional enzyme (PBE) (PBFE) [Includes: Enoyl-CoA hydratase (EC 4.2.1.17); 3,2-trans-enoyl-CoA isomerase (EC 5.3.3.8); 3-hydroxyacyl-CoA dehydrogenase (EC 1.1.1.35)].

ECHP_MOUSE
θ value	7.45998e-71 (rank : 3)	NC score	0.909881 (rank : 2)
Query Neighborhood Hits	28	Target Neighborhood Hits	26	Shared Neighborhood Hits	20
SwissProt Accessions	Q9DBM2	Gene names	Ehhadh
Domain Architecture
Description	Peroxisomal bifunctional enzyme (PBE) (PBFE) [Includes: Enoyl-CoA hydratase (EC 4.2.1.17); 3,2-trans-enoyl-CoA isomerase (EC 5.3.3.8); 3-hydroxyacyl-CoA dehydrogenase (EC 1.1.1.35)].

HCDH_HUMAN
θ value	1.16164e-39 (rank : 4)	NC score	0.689856 (rank : 8)
Query Neighborhood Hits	28	Target Neighborhood Hits	13	Shared Neighborhood Hits	6
SwissProt Accessions	Q16836, O00324, O00397, O00753	Gene names	HADHSC, HAD, SCHAD
Domain Architecture
Description	Short chain 3-hydroxyacyl-CoA dehydrogenase, mitochondrial precursor (EC 1.1.1.35) (HCDH) (Medium and short chain L-3-hydroxyacyl-coenzyme A dehydrogenase).

HCDH_MOUSE
θ value	8.32485e-38 (rank : 5)	NC score	0.685374 (rank : 9)
Query Neighborhood Hits	28	Target Neighborhood Hits	13	Shared Neighborhood Hits	6
SwissProt Accessions	Q61425, Q3TF75, Q3THK8, Q3UFI0, Q8K149, Q925U9	Gene names	Hadhsc, Hadh, Mschad, Schad
Domain Architecture
Description	Short chain 3-hydroxyacyl-CoA dehydrogenase, mitochondrial precursor (EC 1.1.1.35) (HCDH) (Medium and short chain L-3-hydroxyacyl-coenzyme A dehydrogenase).

AUMH_HUMAN
θ value	2.20094e-22 (rank : 6)	NC score	0.736142 (rank : 7)
Query Neighborhood Hits	28	Target Neighborhood Hits	21	Shared Neighborhood Hits	18
SwissProt Accessions	Q13825, Q8WUE4	Gene names	AUH
Domain Architecture
Description	Methylglutaconyl-CoA hydratase, mitochondrial precursor (EC 4.2.1.18) (AU-specific RNA-binding enoyl-CoA hydratase) (AU-binding protein/enoyl-CoA hydratase).

ECHM_MOUSE
θ value	4.9032e-22 (rank : 7)	NC score	0.748255 (rank : 4)
Query Neighborhood Hits	28	Target Neighborhood Hits	18	Shared Neighborhood Hits	18
SwissProt Accessions	Q8BH95, Q3TJK2, Q6GQS2, Q6PEN1, Q99LX7	Gene names	Echs1
Domain Architecture	No domain graphic available
Description	Enoyl-CoA hydratase, mitochondrial precursor (EC 4.2.1.17) (Short chain enoyl-CoA hydratase) (SCEH) (Enoyl-CoA hydratase 1).

AUHM_MOUSE
θ value	8.36355e-22 (rank : 8)	NC score	0.739024 (rank : 5)
Query Neighborhood Hits	28	Target Neighborhood Hits	19	Shared Neighborhood Hits	18
SwissProt Accessions	Q9JLZ3, Q80YD7, Q8QZS0, Q9CY78, Q9D155	Gene names	Auh
Domain Architecture
Description	Methylglutaconyl-CoA hydratase, mitochondrial precursor (EC 4.2.1.18) (AU-specific RNA-binding enoyl-CoA hydratase) (AU-binding enoyl-CoA hydratase) (muAUH).

ECHM_HUMAN
θ value	4.58923e-20 (rank : 9)	NC score	0.738782 (rank : 6)
Query Neighborhood Hits	28	Target Neighborhood Hits	23	Shared Neighborhood Hits	18
SwissProt Accessions	P30084, O00739, Q5VWY1, Q96H54	Gene names	ECHS1
Domain Architecture
Description	Enoyl-CoA hydratase, mitochondrial precursor (EC 4.2.1.17) (Short chain enoyl-CoA hydratase) (SCEH) (Enoyl-CoA hydratase 1).

ECH1_HUMAN
θ value	3.76295e-14 (rank : 10)	NC score	0.667992 (rank : 10)
Query Neighborhood Hits	28	Target Neighborhood Hits	18	Shared Neighborhood Hits	18
SwissProt Accessions	Q13011, Q8WVX0, Q96EZ9	Gene names	ECH1
Domain Architecture
Description	Delta3,5-delta2,4-dienoyl-CoA isomerase, mitochondrial precursor (EC 5.3.3.-).

ECH1_MOUSE
θ value	3.18553e-13 (rank : 11)	NC score	0.648135 (rank : 11)
Query Neighborhood Hits	28	Target Neighborhood Hits	19	Shared Neighborhood Hits	18
SwissProt Accessions	O35459, Q5M8P6	Gene names	Ech1
Domain Architecture
Description	Delta3,5-delta2,4-dienoyl-CoA isomerase, mitochondrial precursor (EC 5.3.3.-).

D3D2_HUMAN
θ value	7.09661e-13 (rank : 12)	NC score	0.587735 (rank : 12)
Query Neighborhood Hits	28	Target Neighborhood Hits	15	Shared Neighborhood Hits	13
SwissProt Accessions	P42126, Q13290, Q7Z2L6, Q9BUB8, Q9BW05	Gene names	DCI
Domain Architecture
Description	3,2-trans-enoyl-CoA isomerase, mitochondrial precursor (EC 5.3.3.8) (Dodecenoyl-CoA isomerase) (Delta(3),delta(2)-enoyl-CoA isomerase) (D3,D2-enoyl-CoA isomerase).

D3D2_MOUSE
θ value	6.00763e-12 (rank : 13)	NC score	0.578353 (rank : 13)
Query Neighborhood Hits	28	Target Neighborhood Hits	14	Shared Neighborhood Hits	13
SwissProt Accessions	P42125	Gene names	Dci
Domain Architecture
Description	3,2-trans-enoyl-CoA isomerase, mitochondrial precursor (EC 5.3.3.8) (Dodecenoyl-CoA isomerase) (Delta(3),delta(2)-enoyl-CoA isomerase) (D3,D2-enoyl-CoA isomerase).

CDYL1_HUMAN
θ value	6.64225e-11 (rank : 14)	NC score	0.474191 (rank : 15)
Query Neighborhood Hits	28	Target Neighborhood Hits	92	Shared Neighborhood Hits	16
SwissProt Accessions	Q9Y232	Gene names	CDYL, CDYL1
Domain Architecture
Description	Chromodomain Y-like protein (CDY-like).

CDYL_MOUSE
θ value	2.52405e-10 (rank : 15)	NC score	0.477684 (rank : 14)
Query Neighborhood Hits	28	Target Neighborhood Hits	69	Shared Neighborhood Hits	16
SwissProt Accessions	Q9WTK2	Gene names	Cdyl
Domain Architecture
Description	Chromodomain Y-like protein (CDY-like).

CDYL2_HUMAN
θ value	9.59137e-10 (rank : 16)	NC score	0.463429 (rank : 18)
Query Neighborhood Hits	28	Target Neighborhood Hits	53	Shared Neighborhood Hits	15
SwissProt Accessions	Q8N8U2	Gene names	CDYL2
Domain Architecture
Description	Chromodomain Y-like protein 2 (CDY-like 2).

CDY1_HUMAN
θ value	5.26297e-08 (rank : 17)	NC score	0.467369 (rank : 16)
Query Neighborhood Hits	28	Target Neighborhood Hits	48	Shared Neighborhood Hits	16
SwissProt Accessions	Q9Y6F8, O14600	Gene names	CDY1
Domain Architecture
Description	Testis-specific chromodomain protein Y 1.

CDY2_HUMAN
θ value	5.26297e-08 (rank : 18)	NC score	0.464938 (rank : 17)
Query Neighborhood Hits	28	Target Neighborhood Hits	49	Shared Neighborhood Hits	16
SwissProt Accessions	Q9Y6F7	Gene names	CDY2A, CDY2
Domain Architecture
Description	Testis-specific chromodomain protein Y 2.

CRYL1_HUMAN
θ value	8.97725e-08 (rank : 19)	NC score	0.403564 (rank : 20)
Query Neighborhood Hits	28	Target Neighborhood Hits	12	Shared Neighborhood Hits	6
SwissProt Accessions	Q9Y2S2, Q7Z4Z9	Gene names	CRYL1, CRY
Domain Architecture
Description	Lambda-crystallin homolog.

PECI_MOUSE
θ value	0.000158464 (rank : 20)	NC score	0.459400 (rank : 19)
Query Neighborhood Hits	28	Target Neighborhood Hits	28	Shared Neighborhood Hits	18
SwissProt Accessions	Q9WUR2	Gene names	Peci
Domain Architecture
Description	Peroxisomal 3,2-trans-enoyl-CoA isomerase (EC 5.3.3.8) (Dodecenoyl-CoA isomerase) (Delta(3),delta(2)-enoyl-CoA isomerase) (D3,D2-enoyl-CoA isomerase).

PECI_HUMAN
θ value	0.0252991 (rank : 21)	NC score	0.374155 (rank : 21)
Query Neighborhood Hits	28	Target Neighborhood Hits	26	Shared Neighborhood Hits	16
SwissProt Accessions	O75521, Q5JYK5, Q8N0X0, Q9BUE9, Q9H0T9, Q9NQH1, Q9NYH7, Q9UN55	Gene names	PECI, DRS1, HCA88
Domain Architecture
Description	Peroxisomal 3,2-trans-enoyl-CoA isomerase (EC 5.3.3.8) (Dodecenoyl-CoA isomerase) (Delta(3),delta(2)-enoyl-CoA isomerase) (D3,D2-enoyl-CoA isomerase) (DBI-related protein 1) (DRS-1) (Hepatocellular carcinoma- associated antigen 88) (NY-REN-1 antigen).

ULK2_HUMAN
θ value	0.163984 (rank : 22)	NC score	0.007638 (rank : 36)
Query Neighborhood Hits	28	Target Neighborhood Hits	979	Shared Neighborhood Hits	3
SwissProt Accessions	Q8IYT8, O75119	Gene names	ULK2, KIAA0623
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase ULK2 (EC 2.7.11.1) (Unc-51-like kinase 2).

ULK2_MOUSE
θ value	0.21417 (rank : 23)	NC score	0.007439 (rank : 37)
Query Neighborhood Hits	28	Target Neighborhood Hits	943	Shared Neighborhood Hits	3
SwissProt Accessions	Q9QY01, Q80TV7, Q9WTP4	Gene names	Ulk2, Kiaa0623
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase ULK2 (EC 2.7.11.1) (Unc-51-like kinase 2) (Serine/threonine-protein kinase Unc51.2).

PAD5_MOUSE
θ value	1.06291 (rank : 24)	NC score	0.025915 (rank : 31)
Query Neighborhood Hits	28	Target Neighborhood Hits	32	Shared Neighborhood Hits	2
SwissProt Accessions	Q68ED3, Q8C0K6	Gene names	Papd5
Domain Architecture	No domain graphic available
Description	PAP-associated domain-containing protein 5 (EC 2.7.7.-) (Topoisomerase-related function protein 4-2) (TRF4-2).

MAGB3_HUMAN
θ value	1.81305 (rank : 25)	NC score	0.010611 (rank : 34)
Query Neighborhood Hits	28	Target Neighborhood Hits	45	Shared Neighborhood Hits	2
SwissProt Accessions	O15480, O75861	Gene names	MAGEB3
Domain Architecture
Description	Melanoma-associated antigen B3 (MAGE-B3 antigen).

REV1_MOUSE
θ value	3.0926 (rank : 26)	NC score	0.018903 (rank : 32)
Query Neighborhood Hits	28	Target Neighborhood Hits	67	Shared Neighborhood Hits	2
SwissProt Accessions	Q920Q2, Q9QXV2	Gene names	Rev1l, Rev1
Domain Architecture	No domain graphic available
Description	DNA repair protein REV1 (EC 2.7.7.-) (Rev1-like terminal deoxycytidyl transferase).

CF146_MOUSE
θ value	8.99809 (rank : 27)	NC score	0.014006 (rank : 33)
Query Neighborhood Hits	28	Target Neighborhood Hits	31	Shared Neighborhood Hits	2
SwissProt Accessions	Q9D9W6	Gene names
Domain Architecture	No domain graphic available
Description	Protein C6orf146 homolog.

WDR60_MOUSE
θ value	8.99809 (rank : 28)	NC score	0.007657 (rank : 35)
Query Neighborhood Hits	28	Target Neighborhood Hits	344	Shared Neighborhood Hits	2
SwissProt Accessions	Q8C761, Q3UNM4	Gene names	Wdr60
Domain Architecture	No domain graphic available
Description	WD repeat protein 60.

CBX1_HUMAN
θ value	θ > 10 (rank : 29)	NC score	0.062442 (rank : 27)
Query Neighborhood Hits	28	Target Neighborhood Hits	44	Shared Neighborhood Hits	5
SwissProt Accessions	P83916, P23197	Gene names	CBX1, CBX
Domain Architecture
Description	Chromobox protein homolog 1 (Heterochromatin protein 1 homolog beta) (HP1 beta) (Modifier 1 protein) (M31) (Heterochromatin protein p25) (HP1Hsbeta) (p25beta).

CBX1_MOUSE
θ value	θ > 10 (rank : 30)	NC score	0.062442 (rank : 28)
Query Neighborhood Hits	28	Target Neighborhood Hits	44	Shared Neighborhood Hits	5
SwissProt Accessions	P83917, P23197	Gene names	Cbx1, Cbx
Domain Architecture
Description	Chromobox protein homolog 1 (Heterochromatin protein 1 homolog beta) (HP1 beta) (Modifier 1 protein) (M31) (Heterochromatin protein p25).

CBX3_HUMAN
θ value	θ > 10 (rank : 31)	NC score	0.062606 (rank : 26)
Query Neighborhood Hits	28	Target Neighborhood Hits	36	Shared Neighborhood Hits	5
SwissProt Accessions	Q13185, Q96CD7, Q99409, Q9BVS3, Q9P0Z6	Gene names	CBX3
Domain Architecture
Description	Chromobox protein homolog 3 (Heterochromatin protein 1 homolog gamma) (HP1 gamma) (Modifier 2 protein) (HECH).

CBX3_MOUSE
θ value	θ > 10 (rank : 32)	NC score	0.067255 (rank : 23)
Query Neighborhood Hits	28	Target Neighborhood Hits	39	Shared Neighborhood Hits	5
SwissProt Accessions	P23198, Q921C4	Gene names	Cbx3
Domain Architecture
Description	Chromobox protein homolog 3 (Heterochromatin protein 1 homolog gamma) (HP1 gamma) (Modifier 2 protein) (M32).

CBX5_HUMAN
θ value	θ > 10 (rank : 33)	NC score	0.062692 (rank : 25)
Query Neighborhood Hits	28	Target Neighborhood Hits	70	Shared Neighborhood Hits	5
SwissProt Accessions	P45973	Gene names	CBX5, HP1A
Domain Architecture
Description	Chromobox protein homolog 5 (Heterochromatin protein 1 homolog alpha) (HP1 alpha) (Antigen p25).

CBX5_MOUSE
θ value	θ > 10 (rank : 34)	NC score	0.063401 (rank : 24)
Query Neighborhood Hits	28	Target Neighborhood Hits	67	Shared Neighborhood Hits	5
SwissProt Accessions	Q61686, Q9CS35, Q9CXD1	Gene names	Cbx5, Hp1a
Domain Architecture
Description	Chromobox protein homolog 5 (Heterochromatin protein 1 homolog alpha) (HP1 alpha).

CBX7_HUMAN
θ value	θ > 10 (rank : 35)	NC score	0.052984 (rank : 30)
Query Neighborhood Hits	28	Target Neighborhood Hits	48	Shared Neighborhood Hits	5
SwissProt Accessions	O95931, Q86T17	Gene names	CBX7
Domain Architecture
Description	Chromobox protein homolog 7.

CBX7_MOUSE
θ value	θ > 10 (rank : 36)	NC score	0.057111 (rank : 29)
Query Neighborhood Hits	28	Target Neighborhood Hits	38	Shared Neighborhood Hits	5
SwissProt Accessions	Q8VDS3	Gene names	Cbx7, D15Ertd417e
Domain Architecture
Description	Chromobox protein homolog 7.

CRYL1_MOUSE
θ value	θ > 10 (rank : 37)	NC score	0.313764 (rank : 22)
Query Neighborhood Hits	28	Target Neighborhood Hits	12	Shared Neighborhood Hits	5
SwissProt Accessions	Q99KP3, Q542R9, Q8R4W7	Gene names	Cryl1, Cry
Domain Architecture
Description	Lambda-crystallin homolog.

Hits sorted by NC score

ECHA_HUMAN
NC score	0.999962 (rank : 1)	θ value	0 (rank : 1)
Query Neighborhood Hits	28	Target Neighborhood Hits	28	Shared Neighborhood Hits	28
SwissProt Accessions	P40939, Q16679, Q96GT7	Gene names	HADHA, HADH
Domain Architecture
Description	Trifunctional enzyme subunit alpha, mitochondrial precursor (TP-alpha) (78 kDa gastrin-binding protein) [Includes: Long-chain enoyl-CoA hydratase (EC 4.2.1.17); Long chain 3-hydroxyacyl-CoA dehydrogenase (EC 1.1.1.211)].

ECHP_MOUSE
NC score	0.909881 (rank : 2)	θ value	7.45998e-71 (rank : 3)
Query Neighborhood Hits	28	Target Neighborhood Hits	26	Shared Neighborhood Hits	20
SwissProt Accessions	Q9DBM2	Gene names	Ehhadh
Domain Architecture
Description	Peroxisomal bifunctional enzyme (PBE) (PBFE) [Includes: Enoyl-CoA hydratase (EC 4.2.1.17); 3,2-trans-enoyl-CoA isomerase (EC 5.3.3.8); 3-hydroxyacyl-CoA dehydrogenase (EC 1.1.1.35)].

ECHP_HUMAN
NC score	0.909260 (rank : 3)	θ value	1.50314e-71 (rank : 2)
Query Neighborhood Hits	28	Target Neighborhood Hits	28	Shared Neighborhood Hits	19
SwissProt Accessions	Q08426	Gene names	EHHADH, ECHD
Domain Architecture
Description	Peroxisomal bifunctional enzyme (PBE) (PBFE) [Includes: Enoyl-CoA hydratase (EC 4.2.1.17); 3,2-trans-enoyl-CoA isomerase (EC 5.3.3.8); 3-hydroxyacyl-CoA dehydrogenase (EC 1.1.1.35)].

ECHM_MOUSE
NC score	0.748255 (rank : 4)	θ value	4.9032e-22 (rank : 7)
Query Neighborhood Hits	28	Target Neighborhood Hits	18	Shared Neighborhood Hits	18
SwissProt Accessions	Q8BH95, Q3TJK2, Q6GQS2, Q6PEN1, Q99LX7	Gene names	Echs1
Domain Architecture	No domain graphic available
Description	Enoyl-CoA hydratase, mitochondrial precursor (EC 4.2.1.17) (Short chain enoyl-CoA hydratase) (SCEH) (Enoyl-CoA hydratase 1).

AUHM_MOUSE
NC score	0.739024 (rank : 5)	θ value	8.36355e-22 (rank : 8)
Query Neighborhood Hits	28	Target Neighborhood Hits	19	Shared Neighborhood Hits	18
SwissProt Accessions	Q9JLZ3, Q80YD7, Q8QZS0, Q9CY78, Q9D155	Gene names	Auh
Domain Architecture
Description	Methylglutaconyl-CoA hydratase, mitochondrial precursor (EC 4.2.1.18) (AU-specific RNA-binding enoyl-CoA hydratase) (AU-binding enoyl-CoA hydratase) (muAUH).

ECHM_HUMAN
NC score	0.738782 (rank : 6)	θ value	4.58923e-20 (rank : 9)
Query Neighborhood Hits	28	Target Neighborhood Hits	23	Shared Neighborhood Hits	18
SwissProt Accessions	P30084, O00739, Q5VWY1, Q96H54	Gene names	ECHS1
Domain Architecture
Description	Enoyl-CoA hydratase, mitochondrial precursor (EC 4.2.1.17) (Short chain enoyl-CoA hydratase) (SCEH) (Enoyl-CoA hydratase 1).

AUMH_HUMAN
NC score	0.736142 (rank : 7)	θ value	2.20094e-22 (rank : 6)
Query Neighborhood Hits	28	Target Neighborhood Hits	21	Shared Neighborhood Hits	18
SwissProt Accessions	Q13825, Q8WUE4	Gene names	AUH
Domain Architecture
Description	Methylglutaconyl-CoA hydratase, mitochondrial precursor (EC 4.2.1.18) (AU-specific RNA-binding enoyl-CoA hydratase) (AU-binding protein/enoyl-CoA hydratase).

HCDH_HUMAN
NC score	0.689856 (rank : 8)	θ value	1.16164e-39 (rank : 4)
Query Neighborhood Hits	28	Target Neighborhood Hits	13	Shared Neighborhood Hits	6
SwissProt Accessions	Q16836, O00324, O00397, O00753	Gene names	HADHSC, HAD, SCHAD
Domain Architecture
Description	Short chain 3-hydroxyacyl-CoA dehydrogenase, mitochondrial precursor (EC 1.1.1.35) (HCDH) (Medium and short chain L-3-hydroxyacyl-coenzyme A dehydrogenase).

HCDH_MOUSE
NC score	0.685374 (rank : 9)	θ value	8.32485e-38 (rank : 5)
Query Neighborhood Hits	28	Target Neighborhood Hits	13	Shared Neighborhood Hits	6
SwissProt Accessions	Q61425, Q3TF75, Q3THK8, Q3UFI0, Q8K149, Q925U9	Gene names	Hadhsc, Hadh, Mschad, Schad
Domain Architecture
Description	Short chain 3-hydroxyacyl-CoA dehydrogenase, mitochondrial precursor (EC 1.1.1.35) (HCDH) (Medium and short chain L-3-hydroxyacyl-coenzyme A dehydrogenase).

ECH1_HUMAN
NC score	0.667992 (rank : 10)	θ value	3.76295e-14 (rank : 10)
Query Neighborhood Hits	28	Target Neighborhood Hits	18	Shared Neighborhood Hits	18
SwissProt Accessions	Q13011, Q8WVX0, Q96EZ9	Gene names	ECH1
Domain Architecture
Description	Delta3,5-delta2,4-dienoyl-CoA isomerase, mitochondrial precursor (EC 5.3.3.-).

ECH1_MOUSE
NC score	0.648135 (rank : 11)	θ value	3.18553e-13 (rank : 11)
Query Neighborhood Hits	28	Target Neighborhood Hits	19	Shared Neighborhood Hits	18
SwissProt Accessions	O35459, Q5M8P6	Gene names	Ech1
Domain Architecture
Description	Delta3,5-delta2,4-dienoyl-CoA isomerase, mitochondrial precursor (EC 5.3.3.-).

D3D2_HUMAN
NC score	0.587735 (rank : 12)	θ value	7.09661e-13 (rank : 12)
Query Neighborhood Hits	28	Target Neighborhood Hits	15	Shared Neighborhood Hits	13
SwissProt Accessions	P42126, Q13290, Q7Z2L6, Q9BUB8, Q9BW05	Gene names	DCI
Domain Architecture
Description	3,2-trans-enoyl-CoA isomerase, mitochondrial precursor (EC 5.3.3.8) (Dodecenoyl-CoA isomerase) (Delta(3),delta(2)-enoyl-CoA isomerase) (D3,D2-enoyl-CoA isomerase).

D3D2_MOUSE
NC score	0.578353 (rank : 13)	θ value	6.00763e-12 (rank : 13)
Query Neighborhood Hits	28	Target Neighborhood Hits	14	Shared Neighborhood Hits	13
SwissProt Accessions	P42125	Gene names	Dci
Domain Architecture
Description	3,2-trans-enoyl-CoA isomerase, mitochondrial precursor (EC 5.3.3.8) (Dodecenoyl-CoA isomerase) (Delta(3),delta(2)-enoyl-CoA isomerase) (D3,D2-enoyl-CoA isomerase).

CDYL_MOUSE
NC score	0.477684 (rank : 14)	θ value	2.52405e-10 (rank : 15)
Query Neighborhood Hits	28	Target Neighborhood Hits	69	Shared Neighborhood Hits	16
SwissProt Accessions	Q9WTK2	Gene names	Cdyl
Domain Architecture
Description	Chromodomain Y-like protein (CDY-like).

CDYL1_HUMAN
NC score	0.474191 (rank : 15)	θ value	6.64225e-11 (rank : 14)
Query Neighborhood Hits	28	Target Neighborhood Hits	92	Shared Neighborhood Hits	16
SwissProt Accessions	Q9Y232	Gene names	CDYL, CDYL1
Domain Architecture
Description	Chromodomain Y-like protein (CDY-like).

CDY1_HUMAN
NC score	0.467369 (rank : 16)	θ value	5.26297e-08 (rank : 17)
Query Neighborhood Hits	28	Target Neighborhood Hits	48	Shared Neighborhood Hits	16
SwissProt Accessions	Q9Y6F8, O14600	Gene names	CDY1
Domain Architecture
Description	Testis-specific chromodomain protein Y 1.

CDY2_HUMAN
NC score	0.464938 (rank : 17)	θ value	5.26297e-08 (rank : 18)
Query Neighborhood Hits	28	Target Neighborhood Hits	49	Shared Neighborhood Hits	16
SwissProt Accessions	Q9Y6F7	Gene names	CDY2A, CDY2
Domain Architecture
Description	Testis-specific chromodomain protein Y 2.

CDYL2_HUMAN
NC score	0.463429 (rank : 18)	θ value	9.59137e-10 (rank : 16)
Query Neighborhood Hits	28	Target Neighborhood Hits	53	Shared Neighborhood Hits	15
SwissProt Accessions	Q8N8U2	Gene names	CDYL2
Domain Architecture
Description	Chromodomain Y-like protein 2 (CDY-like 2).

PECI_MOUSE
NC score	0.459400 (rank : 19)	θ value	0.000158464 (rank : 20)
Query Neighborhood Hits	28	Target Neighborhood Hits	28	Shared Neighborhood Hits	18
SwissProt Accessions	Q9WUR2	Gene names	Peci
Domain Architecture
Description	Peroxisomal 3,2-trans-enoyl-CoA isomerase (EC 5.3.3.8) (Dodecenoyl-CoA isomerase) (Delta(3),delta(2)-enoyl-CoA isomerase) (D3,D2-enoyl-CoA isomerase).

CRYL1_HUMAN
NC score	0.403564 (rank : 20)	θ value	8.97725e-08 (rank : 19)
Query Neighborhood Hits	28	Target Neighborhood Hits	12	Shared Neighborhood Hits	6
SwissProt Accessions	Q9Y2S2, Q7Z4Z9	Gene names	CRYL1, CRY
Domain Architecture
Description	Lambda-crystallin homolog.

PECI_HUMAN
NC score	0.374155 (rank : 21)	θ value	0.0252991 (rank : 21)
Query Neighborhood Hits	28	Target Neighborhood Hits	26	Shared Neighborhood Hits	16
SwissProt Accessions	O75521, Q5JYK5, Q8N0X0, Q9BUE9, Q9H0T9, Q9NQH1, Q9NYH7, Q9UN55	Gene names	PECI, DRS1, HCA88
Domain Architecture
Description	Peroxisomal 3,2-trans-enoyl-CoA isomerase (EC 5.3.3.8) (Dodecenoyl-CoA isomerase) (Delta(3),delta(2)-enoyl-CoA isomerase) (D3,D2-enoyl-CoA isomerase) (DBI-related protein 1) (DRS-1) (Hepatocellular carcinoma- associated antigen 88) (NY-REN-1 antigen).

CRYL1_MOUSE
NC score	0.313764 (rank : 22)	θ value	θ > 10 (rank : 37)
Query Neighborhood Hits	28	Target Neighborhood Hits	12	Shared Neighborhood Hits	5
SwissProt Accessions	Q99KP3, Q542R9, Q8R4W7	Gene names	Cryl1, Cry
Domain Architecture
Description	Lambda-crystallin homolog.

CBX3_MOUSE
NC score	0.067255 (rank : 23)	θ value	θ > 10 (rank : 32)
Query Neighborhood Hits	28	Target Neighborhood Hits	39	Shared Neighborhood Hits	5
SwissProt Accessions	P23198, Q921C4	Gene names	Cbx3
Domain Architecture
Description	Chromobox protein homolog 3 (Heterochromatin protein 1 homolog gamma) (HP1 gamma) (Modifier 2 protein) (M32).

CBX5_MOUSE
NC score	0.063401 (rank : 24)	θ value	θ > 10 (rank : 34)
Query Neighborhood Hits	28	Target Neighborhood Hits	67	Shared Neighborhood Hits	5
SwissProt Accessions	Q61686, Q9CS35, Q9CXD1	Gene names	Cbx5, Hp1a
Domain Architecture
Description	Chromobox protein homolog 5 (Heterochromatin protein 1 homolog alpha) (HP1 alpha).

CBX5_HUMAN
NC score	0.062692 (rank : 25)	θ value	θ > 10 (rank : 33)
Query Neighborhood Hits	28	Target Neighborhood Hits	70	Shared Neighborhood Hits	5
SwissProt Accessions	P45973	Gene names	CBX5, HP1A
Domain Architecture
Description	Chromobox protein homolog 5 (Heterochromatin protein 1 homolog alpha) (HP1 alpha) (Antigen p25).

CBX3_HUMAN
NC score	0.062606 (rank : 26)	θ value	θ > 10 (rank : 31)
Query Neighborhood Hits	28	Target Neighborhood Hits	36	Shared Neighborhood Hits	5
SwissProt Accessions	Q13185, Q96CD7, Q99409, Q9BVS3, Q9P0Z6	Gene names	CBX3
Domain Architecture
Description	Chromobox protein homolog 3 (Heterochromatin protein 1 homolog gamma) (HP1 gamma) (Modifier 2 protein) (HECH).

CBX1_HUMAN
NC score	0.062442 (rank : 27)	θ value	θ > 10 (rank : 29)
Query Neighborhood Hits	28	Target Neighborhood Hits	44	Shared Neighborhood Hits	5
SwissProt Accessions	P83916, P23197	Gene names	CBX1, CBX
Domain Architecture
Description	Chromobox protein homolog 1 (Heterochromatin protein 1 homolog beta) (HP1 beta) (Modifier 1 protein) (M31) (Heterochromatin protein p25) (HP1Hsbeta) (p25beta).

CBX1_MOUSE
NC score	0.062442 (rank : 28)	θ value	θ > 10 (rank : 30)
Query Neighborhood Hits	28	Target Neighborhood Hits	44	Shared Neighborhood Hits	5
SwissProt Accessions	P83917, P23197	Gene names	Cbx1, Cbx
Domain Architecture
Description	Chromobox protein homolog 1 (Heterochromatin protein 1 homolog beta) (HP1 beta) (Modifier 1 protein) (M31) (Heterochromatin protein p25).

CBX7_MOUSE
NC score	0.057111 (rank : 29)	θ value	θ > 10 (rank : 36)
Query Neighborhood Hits	28	Target Neighborhood Hits	38	Shared Neighborhood Hits	5
SwissProt Accessions	Q8VDS3	Gene names	Cbx7, D15Ertd417e
Domain Architecture
Description	Chromobox protein homolog 7.

CBX7_HUMAN
NC score	0.052984 (rank : 30)	θ value	θ > 10 (rank : 35)
Query Neighborhood Hits	28	Target Neighborhood Hits	48	Shared Neighborhood Hits	5
SwissProt Accessions	O95931, Q86T17	Gene names	CBX7
Domain Architecture
Description	Chromobox protein homolog 7.

PAD5_MOUSE
NC score	0.025915 (rank : 31)	θ value	1.06291 (rank : 24)
Query Neighborhood Hits	28	Target Neighborhood Hits	32	Shared Neighborhood Hits	2
SwissProt Accessions	Q68ED3, Q8C0K6	Gene names	Papd5
Domain Architecture	No domain graphic available
Description	PAP-associated domain-containing protein 5 (EC 2.7.7.-) (Topoisomerase-related function protein 4-2) (TRF4-2).

REV1_MOUSE
NC score	0.018903 (rank : 32)	θ value	3.0926 (rank : 26)
Query Neighborhood Hits	28	Target Neighborhood Hits	67	Shared Neighborhood Hits	2
SwissProt Accessions	Q920Q2, Q9QXV2	Gene names	Rev1l, Rev1
Domain Architecture	No domain graphic available
Description	DNA repair protein REV1 (EC 2.7.7.-) (Rev1-like terminal deoxycytidyl transferase).

CF146_MOUSE
NC score	0.014006 (rank : 33)	θ value	8.99809 (rank : 27)
Query Neighborhood Hits	28	Target Neighborhood Hits	31	Shared Neighborhood Hits	2
SwissProt Accessions	Q9D9W6	Gene names
Domain Architecture	No domain graphic available
Description	Protein C6orf146 homolog.

MAGB3_HUMAN
NC score	0.010611 (rank : 34)	θ value	1.81305 (rank : 25)
Query Neighborhood Hits	28	Target Neighborhood Hits	45	Shared Neighborhood Hits	2
SwissProt Accessions	O15480, O75861	Gene names	MAGEB3
Domain Architecture
Description	Melanoma-associated antigen B3 (MAGE-B3 antigen).

WDR60_MOUSE
NC score	0.007657 (rank : 35)	θ value	8.99809 (rank : 28)
Query Neighborhood Hits	28	Target Neighborhood Hits	344	Shared Neighborhood Hits	2
SwissProt Accessions	Q8C761, Q3UNM4	Gene names	Wdr60
Domain Architecture	No domain graphic available
Description	WD repeat protein 60.

ULK2_HUMAN
NC score	0.007638 (rank : 36)	θ value	0.163984 (rank : 22)
Query Neighborhood Hits	28	Target Neighborhood Hits	979	Shared Neighborhood Hits	3
SwissProt Accessions	Q8IYT8, O75119	Gene names	ULK2, KIAA0623
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase ULK2 (EC 2.7.11.1) (Unc-51-like kinase 2).

ULK2_MOUSE
NC score	0.007439 (rank : 37)	θ value	0.21417 (rank : 23)
Query Neighborhood Hits	28	Target Neighborhood Hits	943	Shared Neighborhood Hits	3
SwissProt Accessions	Q9QY01, Q80TV7, Q9WTP4	Gene names	Ulk2, Kiaa0623
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase ULK2 (EC 2.7.11.1) (Unc-51-like kinase 2) (Serine/threonine-protein kinase Unc51.2).