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Network neighborhood for query Sequence : ACES_HUMAN

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ACES_HUMAN
SwissProt Accessions	P22303, Q16169, Q86TM9, Q9BXP7	Gene names	ACHE
Domain Architecture
Description	Acetylcholinesterase precursor (EC 3.1.1.7) (AChE).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

ACES_HUMAN
θ value	0 (rank : 1)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	35	Target Neighborhood Hits	35	Shared Neighborhood Hits	35
SwissProt Accessions	P22303, Q16169, Q86TM9, Q9BXP7	Gene names	ACHE
Domain Architecture
Description	Acetylcholinesterase precursor (EC 3.1.1.7) (AChE).

ACES_MOUSE
θ value	0 (rank : 2)	NC score	0.999428 (rank : 2)
Query Neighborhood Hits	35	Target Neighborhood Hits	29	Shared Neighborhood Hits	26
SwissProt Accessions	P21836	Gene names	Ache
Domain Architecture
Description	Acetylcholinesterase precursor (EC 3.1.1.7) (AChE).

CHLE_HUMAN
θ value	4.52334e-185 (rank : 3)	NC score	0.993595 (rank : 4)
Query Neighborhood Hits	35	Target Neighborhood Hits	35	Shared Neighborhood Hits	25
SwissProt Accessions	P06276	Gene names	BCHE, CHE1
Domain Architecture
Description	Cholinesterase precursor (EC 3.1.1.8) (Acylcholine acylhydrolase) (Choline esterase II) (Butyrylcholine esterase) (Pseudocholinesterase).

CHLE_MOUSE
θ value	4.23373e-183 (rank : 4)	NC score	0.994287 (rank : 3)
Query Neighborhood Hits	35	Target Neighborhood Hits	32	Shared Neighborhood Hits	24
SwissProt Accessions	Q03311	Gene names	Bche
Domain Architecture
Description	Cholinesterase precursor (EC 3.1.1.8) (Acylcholine acylhydrolase) (Choline esterase II) (Butyrylcholine esterase) (Pseudocholinesterase).

NLGN3_MOUSE
θ value	2.02215e-84 (rank : 5)	NC score	0.947251 (rank : 12)
Query Neighborhood Hits	35	Target Neighborhood Hits	48	Shared Neighborhood Hits	23
SwissProt Accessions	Q8BYM5, Q8BXR4	Gene names	Nlgn3
Domain Architecture
Description	Neuroligin-3 precursor (Gliotactin homolog).

NLGNX_HUMAN
θ value	1.71185e-83 (rank : 6)	NC score	0.947549 (rank : 11)
Query Neighborhood Hits	35	Target Neighborhood Hits	35	Shared Neighborhood Hits	23
SwissProt Accessions	Q8N0W4, Q6UX10, Q9ULG0	Gene names	NLGN4X, KIAA1260, NLGN4
Domain Architecture
Description	Neuroligin-4, X-linked precursor (Neuroligin X) (HNLX).

NLGNY_HUMAN
θ value	1.71185e-83 (rank : 7)	NC score	0.947735 (rank : 10)
Query Neighborhood Hits	35	Target Neighborhood Hits	37	Shared Neighborhood Hits	23
SwissProt Accessions	Q8NFZ3, Q7Z3T5, Q9Y2F8	Gene names	NLGN4Y, KIAA0951
Domain Architecture
Description	Neuroligin-4, Y-linked precursor (Neuroligin Y).

NLGN3_HUMAN
θ value	3.22841e-82 (rank : 8)	NC score	0.946449 (rank : 14)
Query Neighborhood Hits	35	Target Neighborhood Hits	45	Shared Neighborhood Hits	23
SwissProt Accessions	Q9NZ94, Q8NCD0, Q9NZ95, Q9NZ96, Q9NZ97, Q9P248	Gene names	NLGN3, KIAA1480, NL3
Domain Architecture
Description	Neuroligin-3 precursor (Gliotactin homolog).

NLGN2_MOUSE
θ value	1.35638e-80 (rank : 9)	NC score	0.949229 (rank : 8)
Query Neighborhood Hits	35	Target Neighborhood Hits	49	Shared Neighborhood Hits	23
SwissProt Accessions	Q69ZK9, Q5F288	Gene names	Nlgn2, Kiaa1366
Domain Architecture	No domain graphic available
Description	Neuroligin-2 precursor.

NLGN2_HUMAN
θ value	3.0217e-80 (rank : 10)	NC score	0.949148 (rank : 9)
Query Neighborhood Hits	35	Target Neighborhood Hits	55	Shared Neighborhood Hits	23
SwissProt Accessions	Q8NFZ4, Q9P2I1	Gene names	NLGN2, KIAA1366
Domain Architecture
Description	Neuroligin-2 precursor.

NLGN1_HUMAN
θ value	3.94648e-80 (rank : 11)	NC score	0.945467 (rank : 15)
Query Neighborhood Hits	35	Target Neighborhood Hits	37	Shared Neighborhood Hits	25
SwissProt Accessions	Q8N2Q7, Q9UPT2	Gene names	NLGN1, KIAA1070
Domain Architecture
Description	Neuroligin-1 precursor.

NLGN1_MOUSE
θ value	1.26953e-78 (rank : 12)	NC score	0.945334 (rank : 17)
Query Neighborhood Hits	35	Target Neighborhood Hits	34	Shared Neighborhood Hits	25
SwissProt Accessions	Q99K10	Gene names	Nlgn1, Kiaa1070
Domain Architecture
Description	Neuroligin-1 precursor.

EST2_HUMAN
θ value	4.08394e-77 (rank : 13)	NC score	0.963808 (rank : 6)
Query Neighborhood Hits	35	Target Neighborhood Hits	38	Shared Neighborhood Hits	27
SwissProt Accessions	O00748, Q16859, Q5MAB8, Q7Z366, Q8IUP4, Q8TCP8	Gene names	CES2, ICE
Domain Architecture
Description	Carboxylesterase 2 precursor (EC 3.1.1.1) (CE-2) (hCE-2).

CEL_MOUSE
θ value	1.22964e-73 (rank : 14)	NC score	0.965638 (rank : 5)
Query Neighborhood Hits	35	Target Neighborhood Hits	28	Shared Neighborhood Hits	25
SwissProt Accessions	Q64285	Gene names	Cel, Lip1
Domain Architecture
Description	Bile salt-activated lipase precursor (EC 3.1.1.3) (EC 3.1.1.13) (BAL) (Bile salt-stimulated lipase) (BSSL) (Carboxyl ester lipase) (Sterol esterase) (Cholesterol esterase) (Pancreatic lysophospholipase).

CEL_HUMAN
θ value	7.45998e-71 (rank : 15)	NC score	0.731713 (rank : 23)
Query Neighborhood Hits	35	Target Neighborhood Hits	896	Shared Neighborhood Hits	30
SwissProt Accessions	P19835, Q16398	Gene names	CEL, BAL
Domain Architecture
Description	Bile salt-activated lipase precursor (EC 3.1.1.3) (EC 3.1.1.13) (BAL) (Bile salt-stimulated lipase) (BSSL) (Carboxyl ester lipase) (Sterol esterase) (Cholesterol esterase) (Pancreatic lysophospholipase).

EST22_MOUSE
θ value	4.23606e-66 (rank : 16)	NC score	0.946819 (rank : 13)
Query Neighborhood Hits	35	Target Neighborhood Hits	34	Shared Neighborhood Hits	27
SwissProt Accessions	Q64176	Gene names	Es22
Domain Architecture
Description	Liver carboxylesterase 22 precursor (EC 3.1.1.1) (Egasyn) (Esterase- 22) (Es-22).

EST1_HUMAN
θ value	3.58603e-65 (rank : 17)	NC score	0.944956 (rank : 18)
Query Neighborhood Hits	35	Target Neighborhood Hits	30	Shared Neighborhood Hits	27
SwissProt Accessions	P23141, Q00015, Q13657, Q14062, Q16737, Q16788, Q86UK2, Q96EE8, Q9UK77, Q9ULY2	Gene names	CES1, CES2, SES1
Domain Architecture
Description	Liver carboxylesterase 1 precursor (EC 3.1.1.1) (Acyl coenzyme A:cholesterol acyltransferase) (ACAT) (Monocyte/macrophage serine esterase) (HMSE) (Serine esterase 1) (Brain carboxylesterase hBr1) (Triacylglycerol hydrolase) (TGH) (Egasyn).

ESTN_MOUSE
θ value	1.36269e-64 (rank : 18)	NC score	0.945423 (rank : 16)
Query Neighborhood Hits	35	Target Neighborhood Hits	34	Shared Neighborhood Hits	27
SwissProt Accessions	P23953, O54936, P11374, Q8K125	Gene names	Es1
Domain Architecture
Description	Liver carboxylesterase N precursor (EC 3.1.1.1) (PES-N) (Lung surfactant convertase).

EST1_MOUSE
θ value	3.35642e-63 (rank : 19)	NC score	0.942414 (rank : 20)
Query Neighborhood Hits	35	Target Neighborhood Hits	28	Shared Neighborhood Hits	27
SwissProt Accessions	Q8VCC2, O55136	Gene names	Ces1
Domain Architecture	No domain graphic available
Description	Liver carboxylesterase 1 precursor (EC 3.1.1.1) (Acyl coenzyme A:cholesterol acyltransferase) (ES-x).

CES3_MOUSE
θ value	3.71096e-62 (rank : 20)	NC score	0.944542 (rank : 19)
Query Neighborhood Hits	35	Target Neighborhood Hits	30	Shared Neighborhood Hits	27
SwissProt Accessions	Q8VCT4, Q91ZV9, Q924V8, Q9ULY1	Gene names	Ces3, Ces1
Domain Architecture	No domain graphic available
Description	Carboxylesterase 3 precursor (EC 3.1.1.1) (Triacylglycerol hydrolase) (TGH).

EST31_MOUSE
θ value	2.40537e-61 (rank : 21)	NC score	0.956874 (rank : 7)
Query Neighborhood Hits	35	Target Neighborhood Hits	31	Shared Neighborhood Hits	25
SwissProt Accessions	Q63880	Gene names	Es31
Domain Architecture
Description	Liver carboxylesterase 31 precursor (EC 3.1.1.1) (ES-Male) (Esterase- 31).

THYG_MOUSE
θ value	1.55911e-60 (rank : 22)	NC score	0.844364 (rank : 21)
Query Neighborhood Hits	35	Target Neighborhood Hits	161	Shared Neighborhood Hits	23
SwissProt Accessions	O08710, O88590, Q9QWY7	Gene names	Tg, Tgn
Domain Architecture
Description	Thyroglobulin precursor.

THYG_HUMAN
θ value	4.53632e-60 (rank : 23)	NC score	0.832330 (rank : 22)
Query Neighborhood Hits	35	Target Neighborhood Hits	154	Shared Neighborhood Hits	23
SwissProt Accessions	P01266, O15274, O43899, Q15593, Q15948, Q9NYR1, Q9NYR2, Q9UMZ0, Q9UNY3	Gene names	TG
Domain Architecture
Description	Thyroglobulin precursor.

AAAD_HUMAN
θ value	0.00665767 (rank : 24)	NC score	0.277583 (rank : 24)
Query Neighborhood Hits	35	Target Neighborhood Hits	22	Shared Neighborhood Hits	17
SwissProt Accessions	P22760, Q8N1A9	Gene names	AADAC, DAC
Domain Architecture
Description	Arylacetamide deacetylase (EC 3.1.1.-) (AADAC).

AAAD_MOUSE
θ value	0.47712 (rank : 25)	NC score	0.162769 (rank : 25)
Query Neighborhood Hits	35	Target Neighborhood Hits	24	Shared Neighborhood Hits	16
SwissProt Accessions	Q99PG0, Q8VCF2	Gene names	Aadac, Aada
Domain Architecture	No domain graphic available
Description	Arylacetamide deacetylase (EC 3.1.1.-) (AADAC).

M3K12_MOUSE
θ value	0.47712 (rank : 26)	NC score	0.000628 (rank : 35)
Query Neighborhood Hits	35	Target Neighborhood Hits	957	Shared Neighborhood Hits	4
SwissProt Accessions	Q60700, P70286, Q3TLL7, Q8C4N7, Q8CBX3, Q8CDL6	Gene names	Map3k12, Zpk
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 12 (EC 2.7.11.25) (Mixed lineage kinase) (Leucine-zipper protein kinase) (ZPK) (Dual leucine zipper bearing kinase) (DLK) (MAPK-upstream kinase) (MUK).

M3K12_HUMAN
θ value	3.0926 (rank : 27)	NC score	-0.000113 (rank : 36)
Query Neighborhood Hits	35	Target Neighborhood Hits	940	Shared Neighborhood Hits	4
SwissProt Accessions	Q12852, Q86VQ5, Q8WY25	Gene names	MAP3K12, ZPK
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 12 (EC 2.7.11.25) (Mixed lineage kinase) (Leucine-zipper protein kinase) (ZPK) (Dual leucine zipper bearing kinase) (DLK) (MAPK-upstream kinase) (MUK).

CPSF6_HUMAN
θ value	4.03905 (rank : 28)	NC score	0.051712 (rank : 28)
Query Neighborhood Hits	35	Target Neighborhood Hits	359	Shared Neighborhood Hits	10
SwissProt Accessions	Q16630, Q53ES1, Q9BSJ7, Q9BW18	Gene names	CPSF6, CFIM68
Domain Architecture	No domain graphic available
Description	Cleavage and polyadenylation specificity factor 6 (Cleavage and polyadenylation specificity factor 68 kDa subunit) (CPSF 68 kDa subunit) (Pre-mRNA cleavage factor Im 68 kDa subunit) (Protein HPBRII- 4/7).

CPSF6_MOUSE
θ value	4.03905 (rank : 29)	NC score	0.055174 (rank : 27)
Query Neighborhood Hits	35	Target Neighborhood Hits	356	Shared Neighborhood Hits	10
SwissProt Accessions	Q6NVF9, Q8BX86, Q8BXI8	Gene names	Cpsf6
Domain Architecture	No domain graphic available
Description	Cleavage and polyadenylation specificity factor 6.

SOX8_HUMAN
θ value	4.03905 (rank : 30)	NC score	0.003475 (rank : 34)
Query Neighborhood Hits	35	Target Neighborhood Hits	100	Shared Neighborhood Hits	2
SwissProt Accessions	P57073, Q9NZW2	Gene names	SOX8
Domain Architecture
Description	Transcription factor SOX-8.

CS007_MOUSE
θ value	6.88961 (rank : 31)	NC score	0.009895 (rank : 31)
Query Neighborhood Hits	35	Target Neighborhood Hits	464	Shared Neighborhood Hits	3
SwissProt Accessions	Q6ZPZ3	Gene names	Kiaa1064
Domain Architecture	No domain graphic available
Description	Zinc finger CCCH domain-containing protein C19orf7 homolog.

PHLD2_HUMAN
θ value	6.88961 (rank : 32)	NC score	0.007214 (rank : 32)
Query Neighborhood Hits	35	Target Neighborhood Hits	44	Shared Neighborhood Hits	3
SwissProt Accessions	Q15127	Gene names	GPLD2, PIGPLD2
Domain Architecture
Description	Phosphatidylinositol-glycan-specific phospholipase D 2 precursor (EC 3.1.4.50) (PI-G PLD) (Glycoprotein phospholipase D) (Glycosyl- phosphatidylinositol-specific phospholipase D).

PPGB_MOUSE
θ value	6.88961 (rank : 33)	NC score	0.010125 (rank : 30)
Query Neighborhood Hits	35	Target Neighborhood Hits	9	Shared Neighborhood Hits	3
SwissProt Accessions	P16675, Q8VEF6	Gene names	Ppgb
Domain Architecture
Description	Lysosomal protective protein precursor (EC 3.4.16.5) (Cathepsin A) (Carboxypeptidase C) (Protective protein for beta-galactosidase) [Contains: Lysosomal protective protein 32 kDa chain; Lysosomal protective protein 20 kDa chain].

PHLD1_HUMAN
θ value	8.99809 (rank : 34)	NC score	0.006685 (rank : 33)
Query Neighborhood Hits	35	Target Neighborhood Hits	48	Shared Neighborhood Hits	3
SwissProt Accessions	P80108, Q15128	Gene names	GPLD1, PIGPLD1
Domain Architecture
Description	Phosphatidylinositol-glycan-specific phospholipase D 1 precursor (EC 3.1.4.50) (PI-G PLD) (Glycoprotein phospholipase D) (Glycosyl- phosphatidylinositol-specific phospholipase D).

PPGB_HUMAN
θ value	8.99809 (rank : 35)	NC score	0.013793 (rank : 29)
Query Neighborhood Hits	35	Target Neighborhood Hits	10	Shared Neighborhood Hits	4
SwissProt Accessions	P10619, Q5JZH1, Q96KJ2, Q9BR08, Q9BW68	Gene names	PPGB
Domain Architecture
Description	Lysosomal protective protein precursor (EC 3.4.16.5) (Cathepsin A) (Carboxypeptidase C) (Protective protein for beta-galactosidase) [Contains: Lysosomal protective protein 32 kDa chain; Lysosomal protective protein 20 kDa chain].

SMR3B_HUMAN
θ value	θ > 10 (rank : 36)	NC score	0.075145 (rank : 26)
Query Neighborhood Hits	35	Target Neighborhood Hits	46	Shared Neighborhood Hits	3
SwissProt Accessions	P02814, Q9UBN0, Q9UCT0	Gene names	SMR3B, PBII, PROL3
Domain Architecture	No domain graphic available
Description	Submaxillary gland androgen-regulated protein 3 homolog B precursor (Proline-rich protein 3) (Proline-rich peptide P-B) [Contains: Peptide P-A; Peptide D1A].

Hits sorted by NC score

ACES_HUMAN
NC score	0.999962 (rank : 1)	θ value	0 (rank : 1)
Query Neighborhood Hits	35	Target Neighborhood Hits	35	Shared Neighborhood Hits	35
SwissProt Accessions	P22303, Q16169, Q86TM9, Q9BXP7	Gene names	ACHE
Domain Architecture
Description	Acetylcholinesterase precursor (EC 3.1.1.7) (AChE).

ACES_MOUSE
NC score	0.999428 (rank : 2)	θ value	0 (rank : 2)
Query Neighborhood Hits	35	Target Neighborhood Hits	29	Shared Neighborhood Hits	26
SwissProt Accessions	P21836	Gene names	Ache
Domain Architecture
Description	Acetylcholinesterase precursor (EC 3.1.1.7) (AChE).

CHLE_MOUSE
NC score	0.994287 (rank : 3)	θ value	4.23373e-183 (rank : 4)
Query Neighborhood Hits	35	Target Neighborhood Hits	32	Shared Neighborhood Hits	24
SwissProt Accessions	Q03311	Gene names	Bche
Domain Architecture
Description	Cholinesterase precursor (EC 3.1.1.8) (Acylcholine acylhydrolase) (Choline esterase II) (Butyrylcholine esterase) (Pseudocholinesterase).

CHLE_HUMAN
NC score	0.993595 (rank : 4)	θ value	4.52334e-185 (rank : 3)
Query Neighborhood Hits	35	Target Neighborhood Hits	35	Shared Neighborhood Hits	25
SwissProt Accessions	P06276	Gene names	BCHE, CHE1
Domain Architecture
Description	Cholinesterase precursor (EC 3.1.1.8) (Acylcholine acylhydrolase) (Choline esterase II) (Butyrylcholine esterase) (Pseudocholinesterase).

CEL_MOUSE
NC score	0.965638 (rank : 5)	θ value	1.22964e-73 (rank : 14)
Query Neighborhood Hits	35	Target Neighborhood Hits	28	Shared Neighborhood Hits	25
SwissProt Accessions	Q64285	Gene names	Cel, Lip1
Domain Architecture
Description	Bile salt-activated lipase precursor (EC 3.1.1.3) (EC 3.1.1.13) (BAL) (Bile salt-stimulated lipase) (BSSL) (Carboxyl ester lipase) (Sterol esterase) (Cholesterol esterase) (Pancreatic lysophospholipase).

EST2_HUMAN
NC score	0.963808 (rank : 6)	θ value	4.08394e-77 (rank : 13)
Query Neighborhood Hits	35	Target Neighborhood Hits	38	Shared Neighborhood Hits	27
SwissProt Accessions	O00748, Q16859, Q5MAB8, Q7Z366, Q8IUP4, Q8TCP8	Gene names	CES2, ICE
Domain Architecture
Description	Carboxylesterase 2 precursor (EC 3.1.1.1) (CE-2) (hCE-2).

EST31_MOUSE
NC score	0.956874 (rank : 7)	θ value	2.40537e-61 (rank : 21)
Query Neighborhood Hits	35	Target Neighborhood Hits	31	Shared Neighborhood Hits	25
SwissProt Accessions	Q63880	Gene names	Es31
Domain Architecture
Description	Liver carboxylesterase 31 precursor (EC 3.1.1.1) (ES-Male) (Esterase- 31).

NLGN2_MOUSE
NC score	0.949229 (rank : 8)	θ value	1.35638e-80 (rank : 9)
Query Neighborhood Hits	35	Target Neighborhood Hits	49	Shared Neighborhood Hits	23
SwissProt Accessions	Q69ZK9, Q5F288	Gene names	Nlgn2, Kiaa1366
Domain Architecture	No domain graphic available
Description	Neuroligin-2 precursor.

NLGN2_HUMAN
NC score	0.949148 (rank : 9)	θ value	3.0217e-80 (rank : 10)
Query Neighborhood Hits	35	Target Neighborhood Hits	55	Shared Neighborhood Hits	23
SwissProt Accessions	Q8NFZ4, Q9P2I1	Gene names	NLGN2, KIAA1366
Domain Architecture
Description	Neuroligin-2 precursor.

NLGNY_HUMAN
NC score	0.947735 (rank : 10)	θ value	1.71185e-83 (rank : 7)
Query Neighborhood Hits	35	Target Neighborhood Hits	37	Shared Neighborhood Hits	23
SwissProt Accessions	Q8NFZ3, Q7Z3T5, Q9Y2F8	Gene names	NLGN4Y, KIAA0951
Domain Architecture
Description	Neuroligin-4, Y-linked precursor (Neuroligin Y).

NLGNX_HUMAN
NC score	0.947549 (rank : 11)	θ value	1.71185e-83 (rank : 6)
Query Neighborhood Hits	35	Target Neighborhood Hits	35	Shared Neighborhood Hits	23
SwissProt Accessions	Q8N0W4, Q6UX10, Q9ULG0	Gene names	NLGN4X, KIAA1260, NLGN4
Domain Architecture
Description	Neuroligin-4, X-linked precursor (Neuroligin X) (HNLX).

NLGN3_MOUSE
NC score	0.947251 (rank : 12)	θ value	2.02215e-84 (rank : 5)
Query Neighborhood Hits	35	Target Neighborhood Hits	48	Shared Neighborhood Hits	23
SwissProt Accessions	Q8BYM5, Q8BXR4	Gene names	Nlgn3
Domain Architecture
Description	Neuroligin-3 precursor (Gliotactin homolog).

EST22_MOUSE
NC score	0.946819 (rank : 13)	θ value	4.23606e-66 (rank : 16)
Query Neighborhood Hits	35	Target Neighborhood Hits	34	Shared Neighborhood Hits	27
SwissProt Accessions	Q64176	Gene names	Es22
Domain Architecture
Description	Liver carboxylesterase 22 precursor (EC 3.1.1.1) (Egasyn) (Esterase- 22) (Es-22).

NLGN3_HUMAN
NC score	0.946449 (rank : 14)	θ value	3.22841e-82 (rank : 8)
Query Neighborhood Hits	35	Target Neighborhood Hits	45	Shared Neighborhood Hits	23
SwissProt Accessions	Q9NZ94, Q8NCD0, Q9NZ95, Q9NZ96, Q9NZ97, Q9P248	Gene names	NLGN3, KIAA1480, NL3
Domain Architecture
Description	Neuroligin-3 precursor (Gliotactin homolog).

NLGN1_HUMAN
NC score	0.945467 (rank : 15)	θ value	3.94648e-80 (rank : 11)
Query Neighborhood Hits	35	Target Neighborhood Hits	37	Shared Neighborhood Hits	25
SwissProt Accessions	Q8N2Q7, Q9UPT2	Gene names	NLGN1, KIAA1070
Domain Architecture
Description	Neuroligin-1 precursor.

ESTN_MOUSE
NC score	0.945423 (rank : 16)	θ value	1.36269e-64 (rank : 18)
Query Neighborhood Hits	35	Target Neighborhood Hits	34	Shared Neighborhood Hits	27
SwissProt Accessions	P23953, O54936, P11374, Q8K125	Gene names	Es1
Domain Architecture
Description	Liver carboxylesterase N precursor (EC 3.1.1.1) (PES-N) (Lung surfactant convertase).

NLGN1_MOUSE
NC score	0.945334 (rank : 17)	θ value	1.26953e-78 (rank : 12)
Query Neighborhood Hits	35	Target Neighborhood Hits	34	Shared Neighborhood Hits	25
SwissProt Accessions	Q99K10	Gene names	Nlgn1, Kiaa1070
Domain Architecture
Description	Neuroligin-1 precursor.

EST1_HUMAN
NC score	0.944956 (rank : 18)	θ value	3.58603e-65 (rank : 17)
Query Neighborhood Hits	35	Target Neighborhood Hits	30	Shared Neighborhood Hits	27
SwissProt Accessions	P23141, Q00015, Q13657, Q14062, Q16737, Q16788, Q86UK2, Q96EE8, Q9UK77, Q9ULY2	Gene names	CES1, CES2, SES1
Domain Architecture
Description	Liver carboxylesterase 1 precursor (EC 3.1.1.1) (Acyl coenzyme A:cholesterol acyltransferase) (ACAT) (Monocyte/macrophage serine esterase) (HMSE) (Serine esterase 1) (Brain carboxylesterase hBr1) (Triacylglycerol hydrolase) (TGH) (Egasyn).

CES3_MOUSE
NC score	0.944542 (rank : 19)	θ value	3.71096e-62 (rank : 20)
Query Neighborhood Hits	35	Target Neighborhood Hits	30	Shared Neighborhood Hits	27
SwissProt Accessions	Q8VCT4, Q91ZV9, Q924V8, Q9ULY1	Gene names	Ces3, Ces1
Domain Architecture	No domain graphic available
Description	Carboxylesterase 3 precursor (EC 3.1.1.1) (Triacylglycerol hydrolase) (TGH).

EST1_MOUSE
NC score	0.942414 (rank : 20)	θ value	3.35642e-63 (rank : 19)
Query Neighborhood Hits	35	Target Neighborhood Hits	28	Shared Neighborhood Hits	27
SwissProt Accessions	Q8VCC2, O55136	Gene names	Ces1
Domain Architecture	No domain graphic available
Description	Liver carboxylesterase 1 precursor (EC 3.1.1.1) (Acyl coenzyme A:cholesterol acyltransferase) (ES-x).

THYG_MOUSE
NC score	0.844364 (rank : 21)	θ value	1.55911e-60 (rank : 22)
Query Neighborhood Hits	35	Target Neighborhood Hits	161	Shared Neighborhood Hits	23
SwissProt Accessions	O08710, O88590, Q9QWY7	Gene names	Tg, Tgn
Domain Architecture
Description	Thyroglobulin precursor.

THYG_HUMAN
NC score	0.832330 (rank : 22)	θ value	4.53632e-60 (rank : 23)
Query Neighborhood Hits	35	Target Neighborhood Hits	154	Shared Neighborhood Hits	23
SwissProt Accessions	P01266, O15274, O43899, Q15593, Q15948, Q9NYR1, Q9NYR2, Q9UMZ0, Q9UNY3	Gene names	TG
Domain Architecture
Description	Thyroglobulin precursor.

CEL_HUMAN
NC score	0.731713 (rank : 23)	θ value	7.45998e-71 (rank : 15)
Query Neighborhood Hits	35	Target Neighborhood Hits	896	Shared Neighborhood Hits	30
SwissProt Accessions	P19835, Q16398	Gene names	CEL, BAL
Domain Architecture
Description	Bile salt-activated lipase precursor (EC 3.1.1.3) (EC 3.1.1.13) (BAL) (Bile salt-stimulated lipase) (BSSL) (Carboxyl ester lipase) (Sterol esterase) (Cholesterol esterase) (Pancreatic lysophospholipase).

AAAD_HUMAN
NC score	0.277583 (rank : 24)	θ value	0.00665767 (rank : 24)
Query Neighborhood Hits	35	Target Neighborhood Hits	22	Shared Neighborhood Hits	17
SwissProt Accessions	P22760, Q8N1A9	Gene names	AADAC, DAC
Domain Architecture
Description	Arylacetamide deacetylase (EC 3.1.1.-) (AADAC).

AAAD_MOUSE
NC score	0.162769 (rank : 25)	θ value	0.47712 (rank : 25)
Query Neighborhood Hits	35	Target Neighborhood Hits	24	Shared Neighborhood Hits	16
SwissProt Accessions	Q99PG0, Q8VCF2	Gene names	Aadac, Aada
Domain Architecture	No domain graphic available
Description	Arylacetamide deacetylase (EC 3.1.1.-) (AADAC).

SMR3B_HUMAN
NC score	0.075145 (rank : 26)	θ value	θ > 10 (rank : 36)
Query Neighborhood Hits	35	Target Neighborhood Hits	46	Shared Neighborhood Hits	3
SwissProt Accessions	P02814, Q9UBN0, Q9UCT0	Gene names	SMR3B, PBII, PROL3
Domain Architecture	No domain graphic available
Description	Submaxillary gland androgen-regulated protein 3 homolog B precursor (Proline-rich protein 3) (Proline-rich peptide P-B) [Contains: Peptide P-A; Peptide D1A].

CPSF6_MOUSE
NC score	0.055174 (rank : 27)	θ value	4.03905 (rank : 29)
Query Neighborhood Hits	35	Target Neighborhood Hits	356	Shared Neighborhood Hits	10
SwissProt Accessions	Q6NVF9, Q8BX86, Q8BXI8	Gene names	Cpsf6
Domain Architecture	No domain graphic available
Description	Cleavage and polyadenylation specificity factor 6.

CPSF6_HUMAN
NC score	0.051712 (rank : 28)	θ value	4.03905 (rank : 28)
Query Neighborhood Hits	35	Target Neighborhood Hits	359	Shared Neighborhood Hits	10
SwissProt Accessions	Q16630, Q53ES1, Q9BSJ7, Q9BW18	Gene names	CPSF6, CFIM68
Domain Architecture	No domain graphic available
Description	Cleavage and polyadenylation specificity factor 6 (Cleavage and polyadenylation specificity factor 68 kDa subunit) (CPSF 68 kDa subunit) (Pre-mRNA cleavage factor Im 68 kDa subunit) (Protein HPBRII- 4/7).

PPGB_HUMAN
NC score	0.013793 (rank : 29)	θ value	8.99809 (rank : 35)
Query Neighborhood Hits	35	Target Neighborhood Hits	10	Shared Neighborhood Hits	4
SwissProt Accessions	P10619, Q5JZH1, Q96KJ2, Q9BR08, Q9BW68	Gene names	PPGB
Domain Architecture
Description	Lysosomal protective protein precursor (EC 3.4.16.5) (Cathepsin A) (Carboxypeptidase C) (Protective protein for beta-galactosidase) [Contains: Lysosomal protective protein 32 kDa chain; Lysosomal protective protein 20 kDa chain].

PPGB_MOUSE
NC score	0.010125 (rank : 30)	θ value	6.88961 (rank : 33)
Query Neighborhood Hits	35	Target Neighborhood Hits	9	Shared Neighborhood Hits	3
SwissProt Accessions	P16675, Q8VEF6	Gene names	Ppgb
Domain Architecture
Description	Lysosomal protective protein precursor (EC 3.4.16.5) (Cathepsin A) (Carboxypeptidase C) (Protective protein for beta-galactosidase) [Contains: Lysosomal protective protein 32 kDa chain; Lysosomal protective protein 20 kDa chain].

CS007_MOUSE
NC score	0.009895 (rank : 31)	θ value	6.88961 (rank : 31)
Query Neighborhood Hits	35	Target Neighborhood Hits	464	Shared Neighborhood Hits	3
SwissProt Accessions	Q6ZPZ3	Gene names	Kiaa1064
Domain Architecture	No domain graphic available
Description	Zinc finger CCCH domain-containing protein C19orf7 homolog.

PHLD2_HUMAN
NC score	0.007214 (rank : 32)	θ value	6.88961 (rank : 32)
Query Neighborhood Hits	35	Target Neighborhood Hits	44	Shared Neighborhood Hits	3
SwissProt Accessions	Q15127	Gene names	GPLD2, PIGPLD2
Domain Architecture
Description	Phosphatidylinositol-glycan-specific phospholipase D 2 precursor (EC 3.1.4.50) (PI-G PLD) (Glycoprotein phospholipase D) (Glycosyl- phosphatidylinositol-specific phospholipase D).

PHLD1_HUMAN
NC score	0.006685 (rank : 33)	θ value	8.99809 (rank : 34)
Query Neighborhood Hits	35	Target Neighborhood Hits	48	Shared Neighborhood Hits	3
SwissProt Accessions	P80108, Q15128	Gene names	GPLD1, PIGPLD1
Domain Architecture
Description	Phosphatidylinositol-glycan-specific phospholipase D 1 precursor (EC 3.1.4.50) (PI-G PLD) (Glycoprotein phospholipase D) (Glycosyl- phosphatidylinositol-specific phospholipase D).

SOX8_HUMAN
NC score	0.003475 (rank : 34)	θ value	4.03905 (rank : 30)
Query Neighborhood Hits	35	Target Neighborhood Hits	100	Shared Neighborhood Hits	2
SwissProt Accessions	P57073, Q9NZW2	Gene names	SOX8
Domain Architecture
Description	Transcription factor SOX-8.

M3K12_MOUSE
NC score	0.000628 (rank : 35)	θ value	0.47712 (rank : 26)
Query Neighborhood Hits	35	Target Neighborhood Hits	957	Shared Neighborhood Hits	4
SwissProt Accessions	Q60700, P70286, Q3TLL7, Q8C4N7, Q8CBX3, Q8CDL6	Gene names	Map3k12, Zpk
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 12 (EC 2.7.11.25) (Mixed lineage kinase) (Leucine-zipper protein kinase) (ZPK) (Dual leucine zipper bearing kinase) (DLK) (MAPK-upstream kinase) (MUK).

M3K12_HUMAN
NC score	-0.000113 (rank : 36)	θ value	3.0926 (rank : 27)
Query Neighborhood Hits	35	Target Neighborhood Hits	940	Shared Neighborhood Hits	4
SwissProt Accessions	Q12852, Q86VQ5, Q8WY25	Gene names	MAP3K12, ZPK
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 12 (EC 2.7.11.25) (Mixed lineage kinase) (Leucine-zipper protein kinase) (ZPK) (Dual leucine zipper bearing kinase) (DLK) (MAPK-upstream kinase) (MUK).