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Network neighborhood for query Sequence : TRXR1_HUMAN

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TRXR1_HUMAN
SwissProt Accessions	Q16881, Q76P53, Q7LA96, Q9UH79	Gene names	TXNRD1
Domain Architecture
Description	Thioredoxin reductase 1, cytoplasmic precursor (EC 1.8.1.9) (TR) (TR1).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

TRXR1_HUMAN
θ value	0 (rank : 1)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	20	Target Neighborhood Hits	20	Shared Neighborhood Hits	20
SwissProt Accessions	Q16881, Q76P53, Q7LA96, Q9UH79	Gene names	TXNRD1
Domain Architecture
Description	Thioredoxin reductase 1, cytoplasmic precursor (EC 1.8.1.9) (TR) (TR1).

TRXR1_MOUSE
θ value	0 (rank : 2)	NC score	0.999561 (rank : 2)
Query Neighborhood Hits	20	Target Neighborhood Hits	16	Shared Neighborhood Hits	15
SwissProt Accessions	Q9JMH6	Gene names	Txnrd1, Trxr1
Domain Architecture
Description	Thioredoxin reductase 1, cytoplasmic (EC 1.8.1.9) (TR) (TR1).

TRXR2_MOUSE
θ value	3.05528e-157 (rank : 3)	NC score	0.986136 (rank : 4)
Query Neighborhood Hits	20	Target Neighborhood Hits	23	Shared Neighborhood Hits	10
SwissProt Accessions	Q9JLT4, Q91YX4, Q9JHA7, Q9JMH5	Gene names	Txnrd2, Trxr2
Domain Architecture
Description	Thioredoxin reductase 2, mitochondrial precursor (EC 1.8.1.9) (TR3).

TRXR2_HUMAN
θ value	5.96274e-153 (rank : 4)	NC score	0.986632 (rank : 3)
Query Neighborhood Hits	20	Target Neighborhood Hits	18	Shared Neighborhood Hits	10
SwissProt Accessions	Q9NNW7, O95840, Q96IJ2, Q9H2Z5, Q9NZV3, Q9NZV4, Q9P2Y0, Q9P2Y1, Q9UQU8	Gene names	TXNRD2, TRXR2
Domain Architecture
Description	Thioredoxin reductase 2, mitochondrial precursor (EC 1.8.1.9) (TR3) (TR-beta) (Selenoprotein Z) (SelZ).

GSHR_MOUSE
θ value	6.76295e-64 (rank : 5)	NC score	0.928325 (rank : 5)
Query Neighborhood Hits	20	Target Neighborhood Hits	19	Shared Neighborhood Hits	10
SwissProt Accessions	P47791, Q7TNC2, Q8BN97, Q8C9Z6	Gene names	Gsr, Gr1
Domain Architecture
Description	Glutathione reductase, mitochondrial precursor (EC 1.8.1.7) (GR) (GRase).

GSHR_HUMAN
θ value	4.84666e-62 (rank : 6)	NC score	0.927246 (rank : 6)
Query Neighborhood Hits	20	Target Neighborhood Hits	24	Shared Neighborhood Hits	10
SwissProt Accessions	P00390, Q7Z5C9, Q9NP63	Gene names	GSR, GLUR, GRD1
Domain Architecture
Description	Glutathione reductase, mitochondrial precursor (EC 1.8.1.7) (GR) (GRase).

DLDH_HUMAN
θ value	2.3352e-48 (rank : 7)	NC score	0.872623 (rank : 7)
Query Neighborhood Hits	20	Target Neighborhood Hits	34	Shared Neighborhood Hits	9
SwissProt Accessions	P09622, Q14131, Q14167	Gene names	DLD, GCSL, LAD, PHE3
Domain Architecture
Description	Dihydrolipoyl dehydrogenase, mitochondrial precursor (EC 1.8.1.4) (Dihydrolipoamide dehydrogenase) (Glycine cleavage system L protein).

DLDH_MOUSE
θ value	7.51208e-47 (rank : 8)	NC score	0.870021 (rank : 8)
Query Neighborhood Hits	20	Target Neighborhood Hits	35	Shared Neighborhood Hits	9
SwissProt Accessions	O08749	Gene names	Dld
Domain Architecture
Description	Dihydrolipoyl dehydrogenase, mitochondrial precursor (EC 1.8.1.4) (Dihydrolipoamide dehydrogenase).

AOFA_MOUSE
θ value	0.163984 (rank : 9)	NC score	0.058439 (rank : 11)
Query Neighborhood Hits	20	Target Neighborhood Hits	37	Shared Neighborhood Hits	6
SwissProt Accessions	Q64133, Q8K0Z8	Gene names	Maoa
Domain Architecture	No domain graphic available
Description	Amine oxidase [flavin-containing] A (EC 1.4.3.4) (Monoamine oxidase type A) (MAO-A).

ADPN_HUMAN
θ value	0.365318 (rank : 10)	NC score	0.082949 (rank : 9)
Query Neighborhood Hits	20	Target Neighborhood Hits	11	Shared Neighborhood Hits	5
SwissProt Accessions	Q9NST1, Q6P1A1, Q96CB4	Gene names	PNPLA3, ADPN, C22orf20
Domain Architecture
Description	Adiponutrin (iPLA2-epsilon) (Calcium-independent phospholipase A2- epsilon) (Patatin-like phospholipase domain-containing protein 3) [Includes: Triacylglycerol lipase (EC 3.1.1.3); Acylglycerol O- acyltransferase (EC 2.3.1.-)].

AOFB_HUMAN
θ value	4.03905 (rank : 11)	NC score	0.024892 (rank : 15)
Query Neighborhood Hits	20	Target Neighborhood Hits	38	Shared Neighborhood Hits	3
SwissProt Accessions	P27338, Q7Z6S2	Gene names	MAOB
Domain Architecture
Description	Amine oxidase [flavin-containing] B (EC 1.4.3.4) (Monoamine oxidase type B) (MAO-B).

FZD4_HUMAN
θ value	4.03905 (rank : 12)	NC score	0.016207 (rank : 20)
Query Neighborhood Hits	20	Target Neighborhood Hits	54	Shared Neighborhood Hits	6
SwissProt Accessions	Q9ULV1, Q6S9E4	Gene names	FZD4
Domain Architecture
Description	Frizzled-4 precursor (Fz-4) (hFz4) (FzE4).

FZD4_MOUSE
θ value	4.03905 (rank : 13)	NC score	0.016254 (rank : 18)
Query Neighborhood Hits	20	Target Neighborhood Hits	52	Shared Neighborhood Hits	6
SwissProt Accessions	Q61088	Gene names	Fzd4
Domain Architecture
Description	Frizzled-4 precursor (Fz-4) (mFz4).

ICLN_HUMAN
θ value	4.03905 (rank : 14)	NC score	0.032607 (rank : 14)
Query Neighborhood Hits	20	Target Neighborhood Hits	6	Shared Neighborhood Hits	3
SwissProt Accessions	P54105, Q9NRD2, Q9NRD3	Gene names	CLNS1A, ICLN
Domain Architecture
Description	Methylosome subunit pICln (Chloride conductance regulatory protein ICln) (I(Cln)) (Chloride channel, nucleotide sensitive 1A) (Chloride ion current inducer protein) (ClCI) (Reticulocyte pICln).

M2GD_HUMAN
θ value	4.03905 (rank : 15)	NC score	0.021876 (rank : 16)
Query Neighborhood Hits	20	Target Neighborhood Hits	28	Shared Neighborhood Hits	5
SwissProt Accessions	Q9UI17	Gene names	DMGDH
Domain Architecture
Description	Dimethylglycine dehydrogenase, mitochondrial precursor (EC 1.5.99.2) (ME2GLYDH).

FZD8_HUMAN
θ value	5.27518 (rank : 16)	NC score	0.012178 (rank : 22)
Query Neighborhood Hits	20	Target Neighborhood Hits	88	Shared Neighborhood Hits	5
SwissProt Accessions	Q9H461	Gene names	FZD8
Domain Architecture
Description	Frizzled-8 precursor (Fz-8) (hFz8).

FZD8_MOUSE
θ value	5.27518 (rank : 17)	NC score	0.012496 (rank : 21)
Query Neighborhood Hits	20	Target Neighborhood Hits	89	Shared Neighborhood Hits	5
SwissProt Accessions	Q61091	Gene names	Fzd8
Domain Architecture
Description	Frizzled-8 precursor (Fz-8) (mFz8).

TOPB1_MOUSE
θ value	5.27518 (rank : 18)	NC score	0.016252 (rank : 19)
Query Neighborhood Hits	20	Target Neighborhood Hits	89	Shared Neighborhood Hits	3
SwissProt Accessions	Q6ZQF0, Q6P6P0, Q80Y33, Q8BUI0, Q8BUK1, Q8R348, Q91VX3, Q922X8	Gene names	Topbp1, Kiaa0259
Domain Architecture	No domain graphic available
Description	DNA topoisomerase II-binding protein 1 (DNA topoisomerase IIbeta- binding protein 1) (TopBP1).

M2GD_MOUSE
θ value	6.88961 (rank : 19)	NC score	0.016763 (rank : 17)
Query Neighborhood Hits	20	Target Neighborhood Hits	21	Shared Neighborhood Hits	4
SwissProt Accessions	Q9DBT9, Q8R1S7	Gene names	Dmgdh
Domain Architecture
Description	Dimethylglycine dehydrogenase, mitochondrial precursor (EC 1.5.99.2) (ME2GLYDH).

GPDM_HUMAN
θ value	8.99809 (rank : 20)	NC score	0.062273 (rank : 10)
Query Neighborhood Hits	20	Target Neighborhood Hits	116	Shared Neighborhood Hits	10
SwissProt Accessions	P43304, Q59FR1, Q9HAP9	Gene names	GPD2
Domain Architecture
Description	Glycerol-3-phosphate dehydrogenase, mitochondrial precursor (EC 1.1.99.5) (GPD-M) (GPDH-M) (mtGPD).

CJ033_HUMAN
θ value	θ > 10 (rank : 21)	NC score	0.054164 (rank : 13)
Query Neighborhood Hits	20	Target Neighborhood Hits	26	Shared Neighborhood Hits	7
SwissProt Accessions	Q8N2H3, Q5TAA9, Q9BRQ1	Gene names	C10orf33
Domain Architecture	No domain graphic available
Description	Probable oxidoreductase C10orf33 (EC 1.-.-.-).

GPDM_MOUSE
θ value	θ > 10 (rank : 22)	NC score	0.057728 (rank : 12)
Query Neighborhood Hits	20	Target Neighborhood Hits	101	Shared Neighborhood Hits	8
SwissProt Accessions	Q64521, Q61507	Gene names	Gpd2, Gdm1
Domain Architecture
Description	Glycerol-3-phosphate dehydrogenase, mitochondrial precursor (EC 1.1.99.5) (GPD-M) (GPDH-M).

Hits sorted by NC score

TRXR1_HUMAN
NC score	0.999962 (rank : 1)	θ value	0 (rank : 1)
Query Neighborhood Hits	20	Target Neighborhood Hits	20	Shared Neighborhood Hits	20
SwissProt Accessions	Q16881, Q76P53, Q7LA96, Q9UH79	Gene names	TXNRD1
Domain Architecture
Description	Thioredoxin reductase 1, cytoplasmic precursor (EC 1.8.1.9) (TR) (TR1).

TRXR1_MOUSE
NC score	0.999561 (rank : 2)	θ value	0 (rank : 2)
Query Neighborhood Hits	20	Target Neighborhood Hits	16	Shared Neighborhood Hits	15
SwissProt Accessions	Q9JMH6	Gene names	Txnrd1, Trxr1
Domain Architecture
Description	Thioredoxin reductase 1, cytoplasmic (EC 1.8.1.9) (TR) (TR1).

TRXR2_HUMAN
NC score	0.986632 (rank : 3)	θ value	5.96274e-153 (rank : 4)
Query Neighborhood Hits	20	Target Neighborhood Hits	18	Shared Neighborhood Hits	10
SwissProt Accessions	Q9NNW7, O95840, Q96IJ2, Q9H2Z5, Q9NZV3, Q9NZV4, Q9P2Y0, Q9P2Y1, Q9UQU8	Gene names	TXNRD2, TRXR2
Domain Architecture
Description	Thioredoxin reductase 2, mitochondrial precursor (EC 1.8.1.9) (TR3) (TR-beta) (Selenoprotein Z) (SelZ).

TRXR2_MOUSE
NC score	0.986136 (rank : 4)	θ value	3.05528e-157 (rank : 3)
Query Neighborhood Hits	20	Target Neighborhood Hits	23	Shared Neighborhood Hits	10
SwissProt Accessions	Q9JLT4, Q91YX4, Q9JHA7, Q9JMH5	Gene names	Txnrd2, Trxr2
Domain Architecture
Description	Thioredoxin reductase 2, mitochondrial precursor (EC 1.8.1.9) (TR3).

GSHR_MOUSE
NC score	0.928325 (rank : 5)	θ value	6.76295e-64 (rank : 5)
Query Neighborhood Hits	20	Target Neighborhood Hits	19	Shared Neighborhood Hits	10
SwissProt Accessions	P47791, Q7TNC2, Q8BN97, Q8C9Z6	Gene names	Gsr, Gr1
Domain Architecture
Description	Glutathione reductase, mitochondrial precursor (EC 1.8.1.7) (GR) (GRase).

GSHR_HUMAN
NC score	0.927246 (rank : 6)	θ value	4.84666e-62 (rank : 6)
Query Neighborhood Hits	20	Target Neighborhood Hits	24	Shared Neighborhood Hits	10
SwissProt Accessions	P00390, Q7Z5C9, Q9NP63	Gene names	GSR, GLUR, GRD1
Domain Architecture
Description	Glutathione reductase, mitochondrial precursor (EC 1.8.1.7) (GR) (GRase).

DLDH_HUMAN
NC score	0.872623 (rank : 7)	θ value	2.3352e-48 (rank : 7)
Query Neighborhood Hits	20	Target Neighborhood Hits	34	Shared Neighborhood Hits	9
SwissProt Accessions	P09622, Q14131, Q14167	Gene names	DLD, GCSL, LAD, PHE3
Domain Architecture
Description	Dihydrolipoyl dehydrogenase, mitochondrial precursor (EC 1.8.1.4) (Dihydrolipoamide dehydrogenase) (Glycine cleavage system L protein).

DLDH_MOUSE
NC score	0.870021 (rank : 8)	θ value	7.51208e-47 (rank : 8)
Query Neighborhood Hits	20	Target Neighborhood Hits	35	Shared Neighborhood Hits	9
SwissProt Accessions	O08749	Gene names	Dld
Domain Architecture
Description	Dihydrolipoyl dehydrogenase, mitochondrial precursor (EC 1.8.1.4) (Dihydrolipoamide dehydrogenase).

ADPN_HUMAN
NC score	0.082949 (rank : 9)	θ value	0.365318 (rank : 10)
Query Neighborhood Hits	20	Target Neighborhood Hits	11	Shared Neighborhood Hits	5
SwissProt Accessions	Q9NST1, Q6P1A1, Q96CB4	Gene names	PNPLA3, ADPN, C22orf20
Domain Architecture
Description	Adiponutrin (iPLA2-epsilon) (Calcium-independent phospholipase A2- epsilon) (Patatin-like phospholipase domain-containing protein 3) [Includes: Triacylglycerol lipase (EC 3.1.1.3); Acylglycerol O- acyltransferase (EC 2.3.1.-)].

GPDM_HUMAN
NC score	0.062273 (rank : 10)	θ value	8.99809 (rank : 20)
Query Neighborhood Hits	20	Target Neighborhood Hits	116	Shared Neighborhood Hits	10
SwissProt Accessions	P43304, Q59FR1, Q9HAP9	Gene names	GPD2
Domain Architecture
Description	Glycerol-3-phosphate dehydrogenase, mitochondrial precursor (EC 1.1.99.5) (GPD-M) (GPDH-M) (mtGPD).

AOFA_MOUSE
NC score	0.058439 (rank : 11)	θ value	0.163984 (rank : 9)
Query Neighborhood Hits	20	Target Neighborhood Hits	37	Shared Neighborhood Hits	6
SwissProt Accessions	Q64133, Q8K0Z8	Gene names	Maoa
Domain Architecture	No domain graphic available
Description	Amine oxidase [flavin-containing] A (EC 1.4.3.4) (Monoamine oxidase type A) (MAO-A).

GPDM_MOUSE
NC score	0.057728 (rank : 12)	θ value	θ > 10 (rank : 22)
Query Neighborhood Hits	20	Target Neighborhood Hits	101	Shared Neighborhood Hits	8
SwissProt Accessions	Q64521, Q61507	Gene names	Gpd2, Gdm1
Domain Architecture
Description	Glycerol-3-phosphate dehydrogenase, mitochondrial precursor (EC 1.1.99.5) (GPD-M) (GPDH-M).

CJ033_HUMAN
NC score	0.054164 (rank : 13)	θ value	θ > 10 (rank : 21)
Query Neighborhood Hits	20	Target Neighborhood Hits	26	Shared Neighborhood Hits	7
SwissProt Accessions	Q8N2H3, Q5TAA9, Q9BRQ1	Gene names	C10orf33
Domain Architecture	No domain graphic available
Description	Probable oxidoreductase C10orf33 (EC 1.-.-.-).

ICLN_HUMAN
NC score	0.032607 (rank : 14)	θ value	4.03905 (rank : 14)
Query Neighborhood Hits	20	Target Neighborhood Hits	6	Shared Neighborhood Hits	3
SwissProt Accessions	P54105, Q9NRD2, Q9NRD3	Gene names	CLNS1A, ICLN
Domain Architecture
Description	Methylosome subunit pICln (Chloride conductance regulatory protein ICln) (I(Cln)) (Chloride channel, nucleotide sensitive 1A) (Chloride ion current inducer protein) (ClCI) (Reticulocyte pICln).

AOFB_HUMAN
NC score	0.024892 (rank : 15)	θ value	4.03905 (rank : 11)
Query Neighborhood Hits	20	Target Neighborhood Hits	38	Shared Neighborhood Hits	3
SwissProt Accessions	P27338, Q7Z6S2	Gene names	MAOB
Domain Architecture
Description	Amine oxidase [flavin-containing] B (EC 1.4.3.4) (Monoamine oxidase type B) (MAO-B).

M2GD_HUMAN
NC score	0.021876 (rank : 16)	θ value	4.03905 (rank : 15)
Query Neighborhood Hits	20	Target Neighborhood Hits	28	Shared Neighborhood Hits	5
SwissProt Accessions	Q9UI17	Gene names	DMGDH
Domain Architecture
Description	Dimethylglycine dehydrogenase, mitochondrial precursor (EC 1.5.99.2) (ME2GLYDH).

M2GD_MOUSE
NC score	0.016763 (rank : 17)	θ value	6.88961 (rank : 19)
Query Neighborhood Hits	20	Target Neighborhood Hits	21	Shared Neighborhood Hits	4
SwissProt Accessions	Q9DBT9, Q8R1S7	Gene names	Dmgdh
Domain Architecture
Description	Dimethylglycine dehydrogenase, mitochondrial precursor (EC 1.5.99.2) (ME2GLYDH).

FZD4_MOUSE
NC score	0.016254 (rank : 18)	θ value	4.03905 (rank : 13)
Query Neighborhood Hits	20	Target Neighborhood Hits	52	Shared Neighborhood Hits	6
SwissProt Accessions	Q61088	Gene names	Fzd4
Domain Architecture
Description	Frizzled-4 precursor (Fz-4) (mFz4).

TOPB1_MOUSE
NC score	0.016252 (rank : 19)	θ value	5.27518 (rank : 18)
Query Neighborhood Hits	20	Target Neighborhood Hits	89	Shared Neighborhood Hits	3
SwissProt Accessions	Q6ZQF0, Q6P6P0, Q80Y33, Q8BUI0, Q8BUK1, Q8R348, Q91VX3, Q922X8	Gene names	Topbp1, Kiaa0259
Domain Architecture	No domain graphic available
Description	DNA topoisomerase II-binding protein 1 (DNA topoisomerase IIbeta- binding protein 1) (TopBP1).

FZD4_HUMAN
NC score	0.016207 (rank : 20)	θ value	4.03905 (rank : 12)
Query Neighborhood Hits	20	Target Neighborhood Hits	54	Shared Neighborhood Hits	6
SwissProt Accessions	Q9ULV1, Q6S9E4	Gene names	FZD4
Domain Architecture
Description	Frizzled-4 precursor (Fz-4) (hFz4) (FzE4).

FZD8_MOUSE
NC score	0.012496 (rank : 21)	θ value	5.27518 (rank : 17)
Query Neighborhood Hits	20	Target Neighborhood Hits	89	Shared Neighborhood Hits	5
SwissProt Accessions	Q61091	Gene names	Fzd8
Domain Architecture
Description	Frizzled-8 precursor (Fz-8) (mFz8).

FZD8_HUMAN
NC score	0.012178 (rank : 22)	θ value	5.27518 (rank : 16)
Query Neighborhood Hits	20	Target Neighborhood Hits	88	Shared Neighborhood Hits	5
SwissProt Accessions	Q9H461	Gene names	FZD8
Domain Architecture
Description	Frizzled-8 precursor (Fz-8) (hFz8).