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Network neighborhood for query Sequence : TOPB1_MOUSE

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TOPB1_MOUSE
SwissProt Accessions	Q6ZQF0, Q6P6P0, Q80Y33, Q8BUI0, Q8BUK1, Q8R348, Q91VX3, Q922X8	Gene names	Topbp1, Kiaa0259
Domain Architecture	No domain graphic available
Description	DNA topoisomerase II-binding protein 1 (DNA topoisomerase IIbeta- binding protein 1) (TopBP1).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

TOPB1_HUMAN
θ value	0 (rank : 1)	NC score	0.973910 (rank : 2)
Query Neighborhood Hits	89	Target Neighborhood Hits	82	Shared Neighborhood Hits	16
SwissProt Accessions	Q92547, Q7LGC1, Q9UEB9	Gene names	TOPBP1, KIAA0259
Domain Architecture	No domain graphic available
Description	DNA topoisomerase 2-binding protein 1 (DNA topoisomerase II-binding protein 1) (DNA topoisomerase IIbeta-binding protein 1) (TopBP1).

TOPB1_MOUSE
θ value	0 (rank : 2)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	89	Target Neighborhood Hits	89	Shared Neighborhood Hits	89
SwissProt Accessions	Q6ZQF0, Q6P6P0, Q80Y33, Q8BUI0, Q8BUK1, Q8R348, Q91VX3, Q922X8	Gene names	Topbp1, Kiaa0259
Domain Architecture	No domain graphic available
Description	DNA topoisomerase II-binding protein 1 (DNA topoisomerase IIbeta- binding protein 1) (TopBP1).

ECT2_HUMAN
θ value	2.68423e-28 (rank : 3)	NC score	0.364553 (rank : 3)
Query Neighborhood Hits	89	Target Neighborhood Hits	98	Shared Neighborhood Hits	4
SwissProt Accessions	Q9H8V3, Q9NSV8, Q9NVW9	Gene names	ECT2
Domain Architecture
Description	ECT2 protein (Epithelial cell-transforming sequence 2 oncogene).

ECT2_MOUSE
θ value	1.74391e-19 (rank : 4)	NC score	0.322646 (rank : 4)
Query Neighborhood Hits	89	Target Neighborhood Hits	98	Shared Neighborhood Hits	4
SwissProt Accessions	Q07139	Gene names	Ect2
Domain Architecture
Description	ECT2 protein (Epithelial cell-transforming sequence 2 oncogene).

XRCC1_MOUSE
θ value	0.000121331 (rank : 5)	NC score	0.185723 (rank : 5)
Query Neighborhood Hits	89	Target Neighborhood Hits	242	Shared Neighborhood Hits	13
SwissProt Accessions	Q60596, Q3THC5, Q5U435, Q7TNQ5	Gene names	Xrcc1, Xrcc-1
Domain Architecture
Description	DNA-repair protein XRCC1 (X-ray repair cross-complementing protein 1).

MCPH1_HUMAN
θ value	0.00665767 (rank : 6)	NC score	0.171037 (rank : 6)
Query Neighborhood Hits	89	Target Neighborhood Hits	85	Shared Neighborhood Hits	7
SwissProt Accessions	Q8NEM0, Q66GU1, Q9H9C7	Gene names	MCPH1
Domain Architecture
Description	Microcephalin.

XRCC1_HUMAN
θ value	0.0431538 (rank : 7)	NC score	0.150710 (rank : 7)
Query Neighborhood Hits	89	Target Neighborhood Hits	131	Shared Neighborhood Hits	13
SwissProt Accessions	P18887, Q9HCB1	Gene names	XRCC1
Domain Architecture
Description	DNA-repair protein XRCC1 (X-ray repair cross-complementing protein 1).

MCPH1_MOUSE
θ value	0.0736092 (rank : 8)	NC score	0.129130 (rank : 8)
Query Neighborhood Hits	89	Target Neighborhood Hits	116	Shared Neighborhood Hits	7
SwissProt Accessions	Q7TT79, Q8BNI9, Q8C9I7	Gene names	Mcph1
Domain Architecture
Description	Microcephalin.

ZEP1_HUMAN
θ value	0.0961366 (rank : 9)	NC score	0.021574 (rank : 47)
Query Neighborhood Hits	89	Target Neighborhood Hits	1036	Shared Neighborhood Hits	18
SwissProt Accessions	P15822, Q14122	Gene names	HIVEP1, ZNF40
Domain Architecture	No domain graphic available
Description	Zinc finger protein 40 (Human immunodeficiency virus type I enhancer- binding protein 1) (HIV-EP1) (Major histocompatibility complex-binding protein 1) (MBP-1) (Positive regulatory domain II-binding factor 1) (PRDII-BF1).

ZHX2_HUMAN
θ value	0.0961366 (rank : 10)	NC score	0.037704 (rank : 19)
Query Neighborhood Hits	89	Target Neighborhood Hits	347	Shared Neighborhood Hits	7
SwissProt Accessions	Q9Y6X8	Gene names	ZHX2, AFR1, KIAA0854, RAF
Domain Architecture
Description	Zinc fingers and homeoboxes protein 2 (Zinc finger and homeodomain protein 2) (Alpha-fetoprotein regulator 1) (AFP regulator 1) (Regulator of AFP).

BARD1_HUMAN
θ value	0.125558 (rank : 11)	NC score	0.041321 (rank : 14)
Query Neighborhood Hits	89	Target Neighborhood Hits	427	Shared Neighborhood Hits	13
SwissProt Accessions	Q99728, O43574	Gene names	BARD1
Domain Architecture
Description	BRCA1-associated RING domain protein 1 (BARD-1).

BPA1_MOUSE
θ value	0.125558 (rank : 12)	NC score	0.018340 (rank : 55)
Query Neighborhood Hits	89	Target Neighborhood Hits	1477	Shared Neighborhood Hits	19
SwissProt Accessions	Q91ZU6, Q91ZU7	Gene names	Dst, Bpag1
Domain Architecture
Description	Bullous pemphigoid antigen 1, isoforms 1/2/3/4 (BPA) (Hemidesmosomal plaque protein) (Dystonia musculorum protein) (Dystonin).

SON_HUMAN
θ value	0.125558 (rank : 13)	NC score	0.035751 (rank : 20)
Query Neighborhood Hits	89	Target Neighborhood Hits	1568	Shared Neighborhood Hits	39
SwissProt Accessions	P18583, O14487, O95981, Q14120, Q9H7B1, Q9P070, Q9P072, Q9UKP9, Q9UPY0	Gene names	SON, C21orf50, DBP5, KIAA1019, NREBP
Domain Architecture
Description	SON protein (SON3) (Negative regulatory element-binding protein) (NRE- binding protein) (DBP-5) (Bax antagonist selected in saccharomyces 1) (BASS1).

SMC2_HUMAN
θ value	0.21417 (rank : 14)	NC score	0.024576 (rank : 38)
Query Neighborhood Hits	89	Target Neighborhood Hits	1405	Shared Neighborhood Hits	21
SwissProt Accessions	O95347, Q9P1P2	Gene names	SMC2L1, CAPE, SMC2
Domain Architecture
Description	Structural maintenance of chromosome 2-like 1 protein (Chromosome- associated protein E) (hCAP-E) (XCAP-E homolog).

REV1_MOUSE
θ value	0.365318 (rank : 15)	NC score	0.096992 (rank : 9)
Query Neighborhood Hits	89	Target Neighborhood Hits	67	Shared Neighborhood Hits	7
SwissProt Accessions	Q920Q2, Q9QXV2	Gene names	Rev1l, Rev1
Domain Architecture	No domain graphic available
Description	DNA repair protein REV1 (EC 2.7.7.-) (Rev1-like terminal deoxycytidyl transferase).

BAZ1B_HUMAN
θ value	0.47712 (rank : 16)	NC score	0.035025 (rank : 21)
Query Neighborhood Hits	89	Target Neighborhood Hits	701	Shared Neighborhood Hits	15
SwissProt Accessions	Q9UIG0, O95039, O95247, O95277	Gene names	BAZ1B, WBSC10, WBSCR9, WSTF
Domain Architecture
Description	Bromodomain adjacent to zinc finger domain protein 1B (Williams-Beuren syndrome chromosome region 9 protein) (Williams syndrome transcription factor) (hWALP2).

HIC1_MOUSE
θ value	0.47712 (rank : 17)	NC score	0.008260 (rank : 76)
Query Neighborhood Hits	89	Target Neighborhood Hits	863	Shared Neighborhood Hits	16
SwissProt Accessions	Q9R1Y5, Q9R1Y6, Q9R2B0	Gene names	Hic1
Domain Architecture
Description	Hypermethylated in cancer 1 protein (Hic-1).

ST5_HUMAN
θ value	0.47712 (rank : 18)	NC score	0.025897 (rank : 32)
Query Neighborhood Hits	89	Target Neighborhood Hits	151	Shared Neighborhood Hits	6
SwissProt Accessions	P78524, P78523, Q16492, Q7KYY2, Q7KZ12, Q8NE12, Q9BQQ6	Gene names	ST5, DENND2B, HTS1
Domain Architecture	No domain graphic available
Description	Suppression of tumorigenicity 5 (HeLa tumor suppression 1) (DENN domain-containing protein 2B).

ATP5S_MOUSE
θ value	0.62314 (rank : 19)	NC score	0.077590 (rank : 10)
Query Neighborhood Hits	89	Target Neighborhood Hits	15	Shared Neighborhood Hits	3
SwissProt Accessions	Q9CRA7, Q8R2M3	Gene names	Atp5s, Atpw
Domain Architecture	No domain graphic available
Description	ATP synthase subunit s, mitochondrial precursor (ATP synthase coupling factor B) (Mitochondrial ATP synthase regulatory component factor B).

EP400_MOUSE
θ value	0.62314 (rank : 20)	NC score	0.031077 (rank : 27)
Query Neighborhood Hits	89	Target Neighborhood Hits	592	Shared Neighborhood Hits	18
SwissProt Accessions	Q8CHI8, Q80TC8, Q8BXI5, Q8BYW3, Q8C0P6, Q8CHI7, Q8VDF4, Q9DA54	Gene names	Ep400, Kiaa1498
Domain Architecture	No domain graphic available
Description	E1A-binding protein p400 (EC 3.6.1.-) (p400 kDa SWI2/SNF2-related protein) (Domino homolog) (mDomino).

STAR8_HUMAN
θ value	0.62314 (rank : 21)	NC score	0.025847 (rank : 33)
Query Neighborhood Hits	89	Target Neighborhood Hits	216	Shared Neighborhood Hits	10
SwissProt Accessions	Q92502, Q5JST0	Gene names	STARD8, KIAA0189
Domain Architecture
Description	StAR-related lipid transfer protein 8 (StARD8) (START domain- containing protein 8).

CSKI2_MOUSE
θ value	0.813845 (rank : 22)	NC score	0.020876 (rank : 48)
Query Neighborhood Hits	89	Target Neighborhood Hits	812	Shared Neighborhood Hits	19
SwissProt Accessions	Q8VHK1, Q6ZPX1, Q7TS77	Gene names	Caskin2, Kiaa1139
Domain Architecture	No domain graphic available
Description	Caskin-2.

NFM_HUMAN
θ value	0.813845 (rank : 23)	NC score	0.011143 (rank : 69)
Query Neighborhood Hits	89	Target Neighborhood Hits	1328	Shared Neighborhood Hits	28
SwissProt Accessions	P07197	Gene names	NEF3, NEFM, NFM
Domain Architecture
Description	Neurofilament triplet M protein (160 kDa neurofilament protein) (Neurofilament medium polypeptide) (NF-M) (Neurofilament 3).

OBSCN_HUMAN
θ value	0.813845 (rank : 24)	NC score	0.007253 (rank : 79)
Query Neighborhood Hits	89	Target Neighborhood Hits	1931	Shared Neighborhood Hits	24
SwissProt Accessions	Q5VST9, Q2A664, Q5T7G8, Q5T7G9, Q5VSU2, Q86YC7, Q8NHN0, Q8NHN1, Q8NHN2, Q8NHN4, Q8NHN5, Q8NHN6, Q8NHN7, Q8NHN8, Q8NHN9, Q96AA2, Q9HCD3, Q9HCL6	Gene names	OBSCN, KIAA1556, KIAA1639
Domain Architecture	No domain graphic available
Description	Obscurin (Obscurin-myosin light chain kinase) (Obscurin-MLCK) (Obscurin-RhoGEF).

LAMP1_HUMAN
θ value	1.06291 (rank : 25)	NC score	0.033149 (rank : 22)
Query Neighborhood Hits	89	Target Neighborhood Hits	18	Shared Neighborhood Hits	2
SwissProt Accessions	P11279	Gene names	LAMP1
Domain Architecture
Description	Lysosome-associated membrane glycoprotein 1 precursor (LAMP-1) (CD107a antigen).

SPR1B_MOUSE
θ value	1.06291 (rank : 26)	NC score	0.032885 (rank : 23)
Query Neighborhood Hits	89	Target Neighborhood Hits	395	Shared Neighborhood Hits	20
SwissProt Accessions	Q62267	Gene names	Sprr1b
Domain Architecture
Description	Cornifin B (Small proline-rich protein 1B) (SPR1B) (SPR1 B).

HIC1_HUMAN
θ value	1.38821 (rank : 27)	NC score	0.006715 (rank : 82)
Query Neighborhood Hits	89	Target Neighborhood Hits	838	Shared Neighborhood Hits	11
SwissProt Accessions	Q14526	Gene names	HIC1, ZBTB29
Domain Architecture
Description	Hypermethylated in cancer 1 protein (Hic-1) (Zinc finger and BTB domain-containing protein 29).

KCNK4_MOUSE
θ value	1.38821 (rank : 28)	NC score	0.020357 (rank : 49)
Query Neighborhood Hits	89	Target Neighborhood Hits	118	Shared Neighborhood Hits	4
SwissProt Accessions	O88454	Gene names	Kcnk4, Traak
Domain Architecture	No domain graphic available
Description	Potassium channel subfamily K member 4 (TWIK-related arachidonic acid- stimulated potassium channel protein) (TRAAK).

MLL2_HUMAN
θ value	1.38821 (rank : 29)	NC score	0.040627 (rank : 15)
Query Neighborhood Hits	89	Target Neighborhood Hits	1788	Shared Neighborhood Hits	41
SwissProt Accessions	O14686, O14687	Gene names	MLL2, ALR
Domain Architecture
Description	Myeloid/lymphoid or mixed-lineage leukemia protein 2 (ALL1-related protein).

REV1_HUMAN
θ value	1.38821 (rank : 30)	NC score	0.074898 (rank : 11)
Query Neighborhood Hits	89	Target Neighborhood Hits	56	Shared Neighborhood Hits	4
SwissProt Accessions	Q9UBZ9, O95941, Q9C0J4, Q9NUP2	Gene names	REV1L, REV1
Domain Architecture	No domain graphic available
Description	DNA repair protein REV1 (EC 2.7.7.-) (Rev1-like terminal deoxycytidyl transferase) (Alpha integrin-binding protein 80) (AIBP80).

SPR1B_HUMAN
θ value	1.38821 (rank : 31)	NC score	0.039827 (rank : 16)
Query Neighborhood Hits	89	Target Neighborhood Hits	102	Shared Neighborhood Hits	8
SwissProt Accessions	P22528, P22529, P22530, Q5T524	Gene names	SPRR1B
Domain Architecture	No domain graphic available
Description	Cornifin B (Small proline-rich protein IB) (SPR-IB) (14.9 kDa pancornulin).

ZO1_HUMAN
θ value	1.38821 (rank : 32)	NC score	0.015059 (rank : 63)
Query Neighborhood Hits	89	Target Neighborhood Hits	474	Shared Neighborhood Hits	6
SwissProt Accessions	Q07157, Q4ZGJ6	Gene names	TJP1, ZO1
Domain Architecture
Description	Tight junction protein ZO-1 (Zonula occludens 1 protein) (Zona occludens 1 protein) (Tight junction protein 1).

ASPP2_HUMAN
θ value	1.81305 (rank : 33)	NC score	0.023534 (rank : 40)
Query Neighborhood Hits	89	Target Neighborhood Hits	1156	Shared Neighborhood Hits	26
SwissProt Accessions	Q13625, Q12892, Q86X75, Q96KQ3	Gene names	TP53BP2, ASPP2, BBP
Domain Architecture
Description	Apoptosis-stimulating of p53 protein 2 (Tumor suppressor p53-binding protein 2) (p53-binding protein 2) (p53BP2) (53BP2) (Bcl2-binding protein) (Bbp) (NY-REN-51 antigen).

CSPG3_MOUSE
θ value	1.81305 (rank : 34)	NC score	0.009781 (rank : 73)
Query Neighborhood Hits	89	Target Neighborhood Hits	657	Shared Neighborhood Hits	8
SwissProt Accessions	P55066, Q6P1E3, Q8C4F8	Gene names	Cspg3, Ncan
Domain Architecture
Description	Neurocan core protein precursor (Chondroitin sulfate proteoglycan 3).

K1802_MOUSE
θ value	1.81305 (rank : 35)	NC score	0.023869 (rank : 39)
Query Neighborhood Hits	89	Target Neighborhood Hits	1596	Shared Neighborhood Hits	39
SwissProt Accessions	Q8K327, Q3UZ85, Q6ZPI1	Gene names	Kiaa1802, D8Ertd457e
Domain Architecture	No domain graphic available
Description	Zinc finger protein KIAA1802.

K1949_MOUSE
θ value	1.81305 (rank : 36)	NC score	0.032764 (rank : 24)
Query Neighborhood Hits	89	Target Neighborhood Hits	134	Shared Neighborhood Hits	8
SwissProt Accessions	Q8BQ30, Q3UDS6, Q8CEY9, Q8R3D8	Gene names
Domain Architecture	No domain graphic available
Description	Protein KIAA1949 homolog.

MINT_MOUSE
θ value	1.81305 (rank : 37)	NC score	0.022331 (rank : 45)
Query Neighborhood Hits	89	Target Neighborhood Hits	1514	Shared Neighborhood Hits	34
SwissProt Accessions	Q62504, Q80TN9, Q99PS4, Q9QZW2	Gene names	Spen, Kiaa0929, Mint, Sharp
Domain Architecture
Description	Msx2-interacting protein (SPEN homolog) (SMART/HDAC1-associated repressor protein).

VGLL1_HUMAN
θ value	1.81305 (rank : 38)	NC score	0.038494 (rank : 17)
Query Neighborhood Hits	89	Target Neighborhood Hits	12	Shared Neighborhood Hits	2
SwissProt Accessions	Q99990	Gene names	VGLL1, TDU
Domain Architecture	No domain graphic available
Description	Transcription cofactor vestigial-like protein 1 (Vgl-1) (Protein TONDU).

ZN507_HUMAN
θ value	1.81305 (rank : 39)	NC score	0.006620 (rank : 83)
Query Neighborhood Hits	89	Target Neighborhood Hits	739	Shared Neighborhood Hits	8
SwissProt Accessions	Q8TCN5	Gene names	ZNF507
Domain Architecture	No domain graphic available
Description	Zinc finger protein 507.

BAZ1B_MOUSE
θ value	2.36792 (rank : 40)	NC score	0.030764 (rank : 28)
Query Neighborhood Hits	89	Target Neighborhood Hits	394	Shared Neighborhood Hits	8
SwissProt Accessions	Q9Z277, Q9CU68	Gene names	Baz1b, Wbscr9
Domain Architecture
Description	Bromodomain adjacent to zinc finger domain protein 1B (Williams-Beuren syndrome chromosome region 9 protein homolog) (WBRS9).

EP400_HUMAN
θ value	2.36792 (rank : 41)	NC score	0.028959 (rank : 29)
Query Neighborhood Hits	89	Target Neighborhood Hits	556	Shared Neighborhood Hits	21
SwissProt Accessions	Q96L91, O15411, Q6P2F5, Q8N8Q7, Q8NE05, Q96JK7, Q9P230	Gene names	EP400, CAGH32, KIAA1498, KIAA1818, TNRC12
Domain Architecture	No domain graphic available
Description	E1A-binding protein p400 (EC 3.6.1.-) (p400 kDa SWI2/SNF2-related protein) (Domino homolog) (hDomino) (CAG repeat protein 32) (Trinucleotide repeat-containing gene 12 protein).

RTN1_MOUSE
θ value	2.36792 (rank : 42)	NC score	0.022183 (rank : 46)
Query Neighborhood Hits	89	Target Neighborhood Hits	189	Shared Neighborhood Hits	12
SwissProt Accessions	Q8K0T0, Q8K4S4	Gene names	Rtn1, Nsp
Domain Architecture	No domain graphic available
Description	Reticulon-1 (Neuroendocrine-specific protein).

SNX19_HUMAN
θ value	2.36792 (rank : 43)	NC score	0.032193 (rank : 25)
Query Neighborhood Hits	89	Target Neighborhood Hits	123	Shared Neighborhood Hits	5
SwissProt Accessions	Q92543	Gene names	SNX19, KIAA0254
Domain Architecture
Description	Sorting nexin-19.

ANK2_HUMAN
θ value	3.0926 (rank : 44)	NC score	0.016752 (rank : 58)
Query Neighborhood Hits	89	Target Neighborhood Hits	1615	Shared Neighborhood Hits	39
SwissProt Accessions	Q01484, Q01485	Gene names	ANK2
Domain Architecture
Description	Ankyrin-2 (Brain ankyrin) (Ankyrin-B) (Ankyrin, nonerythroid).

CTDP1_MOUSE
θ value	3.0926 (rank : 45)	NC score	0.023524 (rank : 41)
Query Neighborhood Hits	89	Target Neighborhood Hits	146	Shared Neighborhood Hits	5
SwissProt Accessions	Q7TSG2, Q7TSS7, Q9D4S8	Gene names	Ctdp1, Fcp1
Domain Architecture
Description	RNA polymerase II subunit A C-terminal domain phosphatase (EC 3.1.3.16) (TFIIF-associating CTD phosphatase).

EVX1_HUMAN
θ value	3.0926 (rank : 46)	NC score	0.011312 (rank : 68)
Query Neighborhood Hits	89	Target Neighborhood Hits	349	Shared Neighborhood Hits	6
SwissProt Accessions	P49640	Gene names	EVX1
Domain Architecture
Description	Homeobox even-skipped homolog protein 1 (EVX-1).

EVX1_MOUSE
θ value	3.0926 (rank : 47)	NC score	0.011044 (rank : 70)
Query Neighborhood Hits	89	Target Neighborhood Hits	350	Shared Neighborhood Hits	5
SwissProt Accessions	P23683	Gene names	Evx1
Domain Architecture
Description	Homeobox even-skipped homolog protein 1 (EVX-1).

HD_HUMAN
θ value	3.0926 (rank : 48)	NC score	0.022815 (rank : 42)
Query Neighborhood Hits	89	Target Neighborhood Hits	165	Shared Neighborhood Hits	9
SwissProt Accessions	P42858, Q9UQB7	Gene names	HD, IT15
Domain Architecture
Description	Huntingtin (Huntington disease protein) (HD protein).

MLL4_HUMAN
θ value	3.0926 (rank : 49)	NC score	0.027283 (rank : 30)
Query Neighborhood Hits	89	Target Neighborhood Hits	722	Shared Neighborhood Hits	27
SwissProt Accessions	Q9UMN6, O15022, O95836, Q96GP2, Q96IP3, Q9UK25, Q9Y668, Q9Y669	Gene names	MLL4, HRX2, KIAA0304, MLL2, TRX2
Domain Architecture
Description	Myeloid/lymphoid or mixed-lineage leukemia protein 4 (Trithorax homolog 2).

OGFR_HUMAN
θ value	3.0926 (rank : 50)	NC score	0.024920 (rank : 36)
Query Neighborhood Hits	89	Target Neighborhood Hits	1582	Shared Neighborhood Hits	46
SwissProt Accessions	Q9NZT2, O96029, Q4VXW5, Q96CM2, Q9BQW1, Q9H4H0, Q9H7J5, Q9NZT3, Q9NZT4	Gene names	OGFR
Domain Architecture
Description	Opioid growth factor receptor (OGFr) (Zeta-type opioid receptor) (7-60 protein).

CCDC9_HUMAN
θ value	4.03905 (rank : 51)	NC score	0.025540 (rank : 35)
Query Neighborhood Hits	89	Target Neighborhood Hits	175	Shared Neighborhood Hits	9
SwissProt Accessions	Q9Y3X0	Gene names	CCDC9
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 9.

CD2L5_HUMAN
θ value	4.03905 (rank : 52)	NC score	0.003613 (rank : 90)
Query Neighborhood Hits	89	Target Neighborhood Hits	987	Shared Neighborhood Hits	7
SwissProt Accessions	Q14004, Q6DKQ9, Q75MH4, Q75MH5, Q96JN4, Q9H4A0, Q9H4A1, Q9UDR4	Gene names	CDC2L5, CDC2L, CHED, KIAA1791
Domain Architecture
Description	Cell division cycle 2-like protein kinase 5 (EC 2.7.11.22) (CDC2- related protein kinase 5) (Cholinesterase-related cell division controller).

CD2L5_MOUSE
θ value	4.03905 (rank : 53)	NC score	0.003774 (rank : 89)
Query Neighborhood Hits	89	Target Neighborhood Hits	1011	Shared Neighborhood Hits	10
SwissProt Accessions	Q69ZA1, Q80V11, Q8BZG1, Q8K0A4	Gene names	Cdc2l5, Kiaa1791
Domain Architecture	No domain graphic available
Description	Cell division cycle 2-like protein kinase 5 (EC 2.7.11.22) (CDC2- related protein kinase 5).

CNGB1_HUMAN
θ value	4.03905 (rank : 54)	NC score	0.012819 (rank : 66)
Query Neighborhood Hits	89	Target Neighborhood Hits	222	Shared Neighborhood Hits	12
SwissProt Accessions	Q14028, Q14029	Gene names	CNGB1, CNCG4
Domain Architecture
Description	Cyclic nucleotide-gated cation channel 4 (CNG channel 4) (CNG-4) (CNG4) (Cyclic nucleotide-gated cation channel modulatory subunit).

P53_HUMAN
θ value	4.03905 (rank : 55)	NC score	0.020261 (rank : 50)
Query Neighborhood Hits	89	Target Neighborhood Hits	42	Shared Neighborhood Hits	6
SwissProt Accessions	P04637, Q15086, Q15087, Q15088, Q16535, Q16807, Q16808, Q16809, Q16810, Q16811, Q16848, Q86UG1, Q8J016, Q99659, Q9BTM4, Q9HAQ8, Q9NP68, Q9NPJ2, Q9NZD0, Q9UBI2, Q9UQ61	Gene names	TP53, P53
Domain Architecture
Description	Cellular tumor antigen p53 (Tumor suppressor p53) (Phosphoprotein p53) (Antigen NY-CO-13).

PER3_HUMAN
θ value	4.03905 (rank : 56)	NC score	0.019457 (rank : 53)
Query Neighborhood Hits	89	Target Neighborhood Hits	479	Shared Neighborhood Hits	21
SwissProt Accessions	P56645, Q5H8X4, Q969K6, Q96S77, Q96S78, Q9C0J3, Q9NSP9, Q9UGU8	Gene names	PER3
Domain Architecture
Description	Period circadian protein 3 (hPER3).

TITIN_HUMAN
θ value	4.03905 (rank : 57)	NC score	0.007199 (rank : 80)
Query Neighborhood Hits	89	Target Neighborhood Hits	2923	Shared Neighborhood Hits	38
SwissProt Accessions	Q8WZ42, Q10465, Q10466, Q15598, Q2XUS3, Q32Q60, Q4U1Z6, Q6NSG0, Q6PDB1, Q6PJP0, Q7KYM2, Q7KYN4, Q7KYN5, Q7LDM3, Q7Z2X3, Q8TCG8, Q8WZ51, Q8WZ52, Q8WZ53, Q8WZB3, Q92761, Q92762, Q9UD97, Q9UP84, Q9Y6L9	Gene names	TTN
Domain Architecture	No domain graphic available
Description	Titin (EC 2.7.11.1) (Connectin) (Rhabdomyosarcoma antigen MU-RMS- 40.14).

ZN198_HUMAN
θ value	4.03905 (rank : 58)	NC score	0.015587 (rank : 62)
Query Neighborhood Hits	89	Target Neighborhood Hits	128	Shared Neighborhood Hits	2
SwissProt Accessions	Q9UBW7, O43212, O43434, O60898, Q5W0Q4, Q63HP0, Q8NE39, Q9H538, Q9UEU2	Gene names	ZNF198, FIM, RAMP, ZMYM2
Domain Architecture
Description	Zinc finger protein 198 (Zinc finger MYM-type protein 2) (Fused in myeloproliferative disorders protein) (Rearranged in atypical myeloproliferative disorder protein).

ACRO_HUMAN
θ value	5.27518 (rank : 59)	NC score	0.004251 (rank : 88)
Query Neighborhood Hits	89	Target Neighborhood Hits	291	Shared Neighborhood Hits	11
SwissProt Accessions	P10323, Q6ICK2	Gene names	ACR, ACRS
Domain Architecture
Description	Acrosin precursor (EC 3.4.21.10) [Contains: Acrosin light chain; Acrosin heavy chain].

ASPP1_MOUSE
θ value	5.27518 (rank : 60)	NC score	0.022619 (rank : 43)
Query Neighborhood Hits	89	Target Neighborhood Hits	1244	Shared Neighborhood Hits	39
SwissProt Accessions	Q62415	Gene names	Ppp1r13b, Aspp1
Domain Architecture
Description	Apoptosis-stimulating of p53 protein 1 (Protein phosphatase 1 regulatory subunit 13B).

BARD1_MOUSE
θ value	5.27518 (rank : 61)	NC score	0.038075 (rank : 18)
Query Neighborhood Hits	89	Target Neighborhood Hits	411	Shared Neighborhood Hits	12
SwissProt Accessions	O70445	Gene names	Bard1
Domain Architecture
Description	BRCA1-associated RING domain protein 1 (BARD-1).

TACC2_MOUSE
θ value	5.27518 (rank : 62)	NC score	0.016302 (rank : 60)
Query Neighborhood Hits	89	Target Neighborhood Hits	774	Shared Neighborhood Hits	20
SwissProt Accessions	Q9JJG0	Gene names	Tacc2
Domain Architecture
Description	Transforming acidic coiled-coil-containing protein 2.

TRXR1_HUMAN
θ value	5.27518 (rank : 63)	NC score	0.016252 (rank : 61)
Query Neighborhood Hits	89	Target Neighborhood Hits	20	Shared Neighborhood Hits	3
SwissProt Accessions	Q16881, Q76P53, Q7LA96, Q9UH79	Gene names	TXNRD1
Domain Architecture
Description	Thioredoxin reductase 1, cytoplasmic precursor (EC 1.8.1.9) (TR) (TR1).

CASB_MOUSE
θ value	6.88961 (rank : 64)	NC score	0.024881 (rank : 37)
Query Neighborhood Hits	89	Target Neighborhood Hits	18	Shared Neighborhood Hits	3
SwissProt Accessions	P10598, Q543D9, Q8VCT6, Q8VCU8, Q91VI5, Q922Y5, Q9D1U6, Q9D1U7	Gene names	Csn2, Csnb
Domain Architecture
Description	Beta-casein precursor.

CS016_HUMAN
θ value	6.88961 (rank : 65)	NC score	0.031513 (rank : 26)
Query Neighborhood Hits	89	Target Neighborhood Hits	310	Shared Neighborhood Hits	19
SwissProt Accessions	Q8ND99	Gene names	C19orf16
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C19orf16.

CSKI1_HUMAN
θ value	6.88961 (rank : 66)	NC score	0.017134 (rank : 57)
Query Neighborhood Hits	89	Target Neighborhood Hits	997	Shared Neighborhood Hits	30
SwissProt Accessions	Q8WXD9, Q9P2P0	Gene names	CASKIN1, KIAA1306
Domain Architecture	No domain graphic available
Description	Caskin-1 (CASK-interacting protein 1).

DEN1A_HUMAN
θ value	6.88961 (rank : 67)	NC score	0.019944 (rank : 52)
Query Neighborhood Hits	89	Target Neighborhood Hits	176	Shared Neighborhood Hits	11
SwissProt Accessions	Q8TEH3, Q5VWF0, Q8IVD6, Q9H796	Gene names	DENND1A
Domain Architecture	No domain graphic available
Description	DENN domain-containing protein 1A.

DREB_HUMAN
θ value	6.88961 (rank : 68)	NC score	0.017153 (rank : 56)
Query Neighborhood Hits	89	Target Neighborhood Hits	450	Shared Neighborhood Hits	13
SwissProt Accessions	Q16643	Gene names	DBN1
Domain Architecture
Description	Drebrin (Developmentally-regulated brain protein).

GPR64_HUMAN
θ value	6.88961 (rank : 69)	NC score	0.006984 (rank : 81)
Query Neighborhood Hits	89	Target Neighborhood Hits	207	Shared Neighborhood Hits	8
SwissProt Accessions	Q8IZP9, O00406, Q8IWT2, Q8IZE4, Q8IZE5, Q8IZE6, Q8IZE7, Q8IZP3, Q8IZP4	Gene names	GPR64, HE6, TM7LN2
Domain Architecture
Description	G-protein coupled receptor 64 precursor (Epididymis-specific protein 6) (He6 receptor).

GRAP1_MOUSE
θ value	6.88961 (rank : 70)	NC score	0.007360 (rank : 78)
Query Neighborhood Hits	89	Target Neighborhood Hits	1234	Shared Neighborhood Hits	16
SwissProt Accessions	Q8VD04, O35693, Q3T9C3, Q69ZP9	Gene names	Gripap1, DXImx47e, Kiaa1167
Domain Architecture	No domain graphic available
Description	GRIP1-associated protein 1 (GRASP-1) (HCMV-interacting protein).

KNTC2_MOUSE
θ value	6.88961 (rank : 71)	NC score	0.010207 (rank : 72)
Query Neighborhood Hits	89	Target Neighborhood Hits	692	Shared Neighborhood Hits	9
SwissProt Accessions	Q9D0F1, Q3TQT6, Q3UWM5, Q99P70	Gene names	Kntc2, Hec1
Domain Architecture	No domain graphic available
Description	Kinetochore protein Hec1 (Kinetochore-associated protein 2).

REPS2_HUMAN
θ value	6.88961 (rank : 72)	NC score	0.013445 (rank : 65)
Query Neighborhood Hits	89	Target Neighborhood Hits	131	Shared Neighborhood Hits	7
SwissProt Accessions	Q8NFH8, O43428, Q8NFI5	Gene names	REPS2, POB1
Domain Architecture
Description	RalBP1-associated Eps domain-containing protein 2 (RalBP1-interacting protein 2) (Partner of RalBP1).

SF3A1_HUMAN
θ value	6.88961 (rank : 73)	NC score	0.026201 (rank : 31)
Query Neighborhood Hits	89	Target Neighborhood Hits	199	Shared Neighborhood Hits	12
SwissProt Accessions	Q15459	Gene names	SF3A1, SAP114
Domain Architecture
Description	Splicing factor 3 subunit 1 (Spliceosome-associated protein 114) (SAP 114) (SF3a120).

SF3A1_MOUSE
θ value	6.88961 (rank : 74)	NC score	0.025846 (rank : 34)
Query Neighborhood Hits	89	Target Neighborhood Hits	198	Shared Neighborhood Hits	11
SwissProt Accessions	Q8K4Z5, Q8C0M7, Q8C128, Q8C175, Q921T3	Gene names	Sf3a1
Domain Architecture	No domain graphic available
Description	Splicing factor 3 subunit 1 (SF3a120).

UDB10_HUMAN
θ value	6.88961 (rank : 75)	NC score	0.005147 (rank : 87)
Query Neighborhood Hits	89	Target Neighborhood Hits	29	Shared Neighborhood Hits	2
SwissProt Accessions	P36537	Gene names	UGT2B10
Domain Architecture
Description	UDP-glucuronosyltransferase 2B10 precursor (EC 2.4.1.17) (UDPGT).

VINEX_MOUSE
θ value	6.88961 (rank : 76)	NC score	0.008367 (rank : 75)
Query Neighborhood Hits	89	Target Neighborhood Hits	286	Shared Neighborhood Hits	4
SwissProt Accessions	Q9R1Z8, Q62423	Gene names	Sorbs3, Scam1, Sh3d4
Domain Architecture
Description	Vinexin (Sorbin and SH3 domain-containing protein 3) (SH3-containing adapter molecule 1) (SCAM-1) (SH3 domain-containing protein SH3P3).

ACINU_MOUSE
θ value	8.99809 (rank : 77)	NC score	0.018690 (rank : 54)
Query Neighborhood Hits	89	Target Neighborhood Hits	712	Shared Neighborhood Hits	23
SwissProt Accessions	Q9JIX8, Q9CSN7, Q9CSR9, Q9CSX7, Q9R046, Q9R047	Gene names	Acin1, Acinus
Domain Architecture
Description	Apoptotic chromatin condensation inducer in the nucleus (Acinus).

ATBF1_MOUSE
θ value	8.99809 (rank : 78)	NC score	0.011031 (rank : 71)
Query Neighborhood Hits	89	Target Neighborhood Hits	1841	Shared Neighborhood Hits	37
SwissProt Accessions	Q61329	Gene names	Atbf1
Domain Architecture
Description	Alpha-fetoprotein enhancer-binding protein (AT motif-binding factor) (AT-binding transcription factor 1).

BL1S3_HUMAN
θ value	8.99809 (rank : 79)	NC score	0.019998 (rank : 51)
Query Neighborhood Hits	89	Target Neighborhood Hits	17	Shared Neighborhood Hits	3
SwissProt Accessions	Q6QNY0	Gene names	BLOC1S3, BLOS3
Domain Architecture	No domain graphic available
Description	Biogenesis of lysosome-related organelles complex-1 subunit 3 (BLOC subunit 3).

GRIK1_HUMAN
θ value	8.99809 (rank : 80)	NC score	0.005928 (rank : 86)
Query Neighborhood Hits	89	Target Neighborhood Hits	48	Shared Neighborhood Hits	3
SwissProt Accessions	P39086, Q13001, Q86SU9	Gene names	GRIK1, GLUR5
Domain Architecture
Description	Glutamate receptor, ionotropic kainate 1 precursor (Glutamate receptor 5) (GluR-5) (GluR5) (Excitatory amino acid receptor 3) (EAA3).

GRIK1_MOUSE
θ value	8.99809 (rank : 81)	NC score	0.006395 (rank : 85)
Query Neighborhood Hits	89	Target Neighborhood Hits	46	Shared Neighborhood Hits	3
SwissProt Accessions	Q60934	Gene names	Grik1, Glur5
Domain Architecture
Description	Glutamate receptor, ionotropic kainate 1 precursor (Glutamate receptor 5) (GluR-5) (GluR5).

JHD3B_HUMAN
θ value	8.99809 (rank : 82)	NC score	0.007841 (rank : 77)
Query Neighborhood Hits	89	Target Neighborhood Hits	128	Shared Neighborhood Hits	8
SwissProt Accessions	O94953, O75274, Q6P3R5, Q9P1V1, Q9UF40	Gene names	JMJD2B, JHDM3B, KIAA0876
Domain Architecture
Description	JmjC domain-containing histone demethylation protein 3B (EC 1.14.11.-) (Jumonji domain-containing protein 2B).

LAMA5_HUMAN
θ value	8.99809 (rank : 83)	NC score	0.003304 (rank : 91)
Query Neighborhood Hits	89	Target Neighborhood Hits	976	Shared Neighborhood Hits	12
SwissProt Accessions	O15230, Q8WZA7, Q9H1P1	Gene names	LAMA5, KIAA0533, KIAA1907
Domain Architecture
Description	Laminin alpha-5 chain precursor.

MDC1_MOUSE
θ value	8.99809 (rank : 84)	NC score	0.022476 (rank : 44)
Query Neighborhood Hits	89	Target Neighborhood Hits	998	Shared Neighborhood Hits	33
SwissProt Accessions	Q5PSV9, Q5U4D3, Q6ZQH7	Gene names	Mdc1, Kiaa0170
Domain Architecture	No domain graphic available
Description	Mediator of DNA damage checkpoint protein 1.

SC24C_HUMAN
θ value	8.99809 (rank : 85)	NC score	0.012034 (rank : 67)
Query Neighborhood Hits	89	Target Neighborhood Hits	662	Shared Neighborhood Hits	15
SwissProt Accessions	P53992, Q8WV25	Gene names	SEC24C, KIAA0079
Domain Architecture
Description	Protein transport protein Sec24C (SEC24-related protein C).

STAR8_MOUSE
θ value	8.99809 (rank : 86)	NC score	0.016436 (rank : 59)
Query Neighborhood Hits	89	Target Neighborhood Hits	101	Shared Neighborhood Hits	3
SwissProt Accessions	Q8K031, Q3UZC7, Q6A0A8, Q6P5E0, Q8R3X8	Gene names	Stard8, Kiaa0189
Domain Architecture	No domain graphic available
Description	StAR-related lipid transfer protein 8 (StARD8) (START domain- containing protein 8).

TRXR1_MOUSE
θ value	8.99809 (rank : 87)	NC score	0.013875 (rank : 64)
Query Neighborhood Hits	89	Target Neighborhood Hits	16	Shared Neighborhood Hits	3
SwissProt Accessions	Q9JMH6	Gene names	Txnrd1, Trxr1
Domain Architecture
Description	Thioredoxin reductase 1, cytoplasmic (EC 1.8.1.9) (TR) (TR1).

UBP43_HUMAN
θ value	8.99809 (rank : 88)	NC score	0.006561 (rank : 84)
Query Neighborhood Hits	89	Target Neighborhood Hits	144	Shared Neighborhood Hits	5
SwissProt Accessions	Q70EL4, Q8N2C5, Q96DQ6	Gene names	USP43
Domain Architecture	No domain graphic available
Description	Ubiquitin carboxyl-terminal hydrolase 43 (EC 3.1.2.15) (Ubiquitin thioesterase 43) (Ubiquitin-specific-processing protease 43) (Deubiquitinating enzyme 43).

ZF106_HUMAN
θ value	8.99809 (rank : 89)	NC score	0.008941 (rank : 74)
Query Neighborhood Hits	89	Target Neighborhood Hits	470	Shared Neighborhood Hits	14
SwissProt Accessions	Q9H2Y7, Q6NSD9, Q6PEK1, Q86T43, Q86T45, Q86T50, Q86T58, Q86TA9, Q96M37, Q9H7B8	Gene names	ZFP106, ZNF474
Domain Architecture	No domain graphic available
Description	Zinc finger protein 106 homolog (Zfp-106) (Zinc finger protein 474).

ARHGA_HUMAN
θ value	θ > 10 (rank : 90)	NC score	0.056129 (rank : 13)
Query Neighborhood Hits	89	Target Neighborhood Hits	187	Shared Neighborhood Hits	4
SwissProt Accessions	O15013, O14665, Q68D55, Q8IWD9, Q8IY77	Gene names	ARHGEF10, KIAA0294
Domain Architecture
Description	Rho guanine nucleotide exchange factor 10.

ARHGA_MOUSE
θ value	θ > 10 (rank : 91)	NC score	0.059261 (rank : 12)
Query Neighborhood Hits	89	Target Neighborhood Hits	125	Shared Neighborhood Hits	6
SwissProt Accessions	Q8C033, Q5DU38, Q80VH8, Q8BW76, Q922S7	Gene names	Arhgef10, Kiaa0294
Domain Architecture
Description	Rho guanine nucleotide exchange factor 10.

Hits sorted by NC score

TOPB1_MOUSE
NC score	0.999962 (rank : 1)	θ value	0 (rank : 2)
Query Neighborhood Hits	89	Target Neighborhood Hits	89	Shared Neighborhood Hits	89
SwissProt Accessions	Q6ZQF0, Q6P6P0, Q80Y33, Q8BUI0, Q8BUK1, Q8R348, Q91VX3, Q922X8	Gene names	Topbp1, Kiaa0259
Domain Architecture	No domain graphic available
Description	DNA topoisomerase II-binding protein 1 (DNA topoisomerase IIbeta- binding protein 1) (TopBP1).

TOPB1_HUMAN
NC score	0.973910 (rank : 2)	θ value	0 (rank : 1)
Query Neighborhood Hits	89	Target Neighborhood Hits	82	Shared Neighborhood Hits	16
SwissProt Accessions	Q92547, Q7LGC1, Q9UEB9	Gene names	TOPBP1, KIAA0259
Domain Architecture	No domain graphic available
Description	DNA topoisomerase 2-binding protein 1 (DNA topoisomerase II-binding protein 1) (DNA topoisomerase IIbeta-binding protein 1) (TopBP1).

ECT2_HUMAN
NC score	0.364553 (rank : 3)	θ value	2.68423e-28 (rank : 3)
Query Neighborhood Hits	89	Target Neighborhood Hits	98	Shared Neighborhood Hits	4
SwissProt Accessions	Q9H8V3, Q9NSV8, Q9NVW9	Gene names	ECT2
Domain Architecture
Description	ECT2 protein (Epithelial cell-transforming sequence 2 oncogene).

ECT2_MOUSE
NC score	0.322646 (rank : 4)	θ value	1.74391e-19 (rank : 4)
Query Neighborhood Hits	89	Target Neighborhood Hits	98	Shared Neighborhood Hits	4
SwissProt Accessions	Q07139	Gene names	Ect2
Domain Architecture
Description	ECT2 protein (Epithelial cell-transforming sequence 2 oncogene).

XRCC1_MOUSE
NC score	0.185723 (rank : 5)	θ value	0.000121331 (rank : 5)
Query Neighborhood Hits	89	Target Neighborhood Hits	242	Shared Neighborhood Hits	13
SwissProt Accessions	Q60596, Q3THC5, Q5U435, Q7TNQ5	Gene names	Xrcc1, Xrcc-1
Domain Architecture
Description	DNA-repair protein XRCC1 (X-ray repair cross-complementing protein 1).

MCPH1_HUMAN
NC score	0.171037 (rank : 6)	θ value	0.00665767 (rank : 6)
Query Neighborhood Hits	89	Target Neighborhood Hits	85	Shared Neighborhood Hits	7
SwissProt Accessions	Q8NEM0, Q66GU1, Q9H9C7	Gene names	MCPH1
Domain Architecture
Description	Microcephalin.

XRCC1_HUMAN
NC score	0.150710 (rank : 7)	θ value	0.0431538 (rank : 7)
Query Neighborhood Hits	89	Target Neighborhood Hits	131	Shared Neighborhood Hits	13
SwissProt Accessions	P18887, Q9HCB1	Gene names	XRCC1
Domain Architecture
Description	DNA-repair protein XRCC1 (X-ray repair cross-complementing protein 1).

MCPH1_MOUSE
NC score	0.129130 (rank : 8)	θ value	0.0736092 (rank : 8)
Query Neighborhood Hits	89	Target Neighborhood Hits	116	Shared Neighborhood Hits	7
SwissProt Accessions	Q7TT79, Q8BNI9, Q8C9I7	Gene names	Mcph1
Domain Architecture
Description	Microcephalin.

REV1_MOUSE
NC score	0.096992 (rank : 9)	θ value	0.365318 (rank : 15)
Query Neighborhood Hits	89	Target Neighborhood Hits	67	Shared Neighborhood Hits	7
SwissProt Accessions	Q920Q2, Q9QXV2	Gene names	Rev1l, Rev1
Domain Architecture	No domain graphic available
Description	DNA repair protein REV1 (EC 2.7.7.-) (Rev1-like terminal deoxycytidyl transferase).

ATP5S_MOUSE
NC score	0.077590 (rank : 10)	θ value	0.62314 (rank : 19)
Query Neighborhood Hits	89	Target Neighborhood Hits	15	Shared Neighborhood Hits	3
SwissProt Accessions	Q9CRA7, Q8R2M3	Gene names	Atp5s, Atpw
Domain Architecture	No domain graphic available
Description	ATP synthase subunit s, mitochondrial precursor (ATP synthase coupling factor B) (Mitochondrial ATP synthase regulatory component factor B).

REV1_HUMAN
NC score	0.074898 (rank : 11)	θ value	1.38821 (rank : 30)
Query Neighborhood Hits	89	Target Neighborhood Hits	56	Shared Neighborhood Hits	4
SwissProt Accessions	Q9UBZ9, O95941, Q9C0J4, Q9NUP2	Gene names	REV1L, REV1
Domain Architecture	No domain graphic available
Description	DNA repair protein REV1 (EC 2.7.7.-) (Rev1-like terminal deoxycytidyl transferase) (Alpha integrin-binding protein 80) (AIBP80).

ARHGA_MOUSE
NC score	0.059261 (rank : 12)	θ value	θ > 10 (rank : 91)
Query Neighborhood Hits	89	Target Neighborhood Hits	125	Shared Neighborhood Hits	6
SwissProt Accessions	Q8C033, Q5DU38, Q80VH8, Q8BW76, Q922S7	Gene names	Arhgef10, Kiaa0294
Domain Architecture
Description	Rho guanine nucleotide exchange factor 10.

ARHGA_HUMAN
NC score	0.056129 (rank : 13)	θ value	θ > 10 (rank : 90)
Query Neighborhood Hits	89	Target Neighborhood Hits	187	Shared Neighborhood Hits	4
SwissProt Accessions	O15013, O14665, Q68D55, Q8IWD9, Q8IY77	Gene names	ARHGEF10, KIAA0294
Domain Architecture
Description	Rho guanine nucleotide exchange factor 10.

BARD1_HUMAN
NC score	0.041321 (rank : 14)	θ value	0.125558 (rank : 11)
Query Neighborhood Hits	89	Target Neighborhood Hits	427	Shared Neighborhood Hits	13
SwissProt Accessions	Q99728, O43574	Gene names	BARD1
Domain Architecture
Description	BRCA1-associated RING domain protein 1 (BARD-1).

MLL2_HUMAN
NC score	0.040627 (rank : 15)	θ value	1.38821 (rank : 29)
Query Neighborhood Hits	89	Target Neighborhood Hits	1788	Shared Neighborhood Hits	41
SwissProt Accessions	O14686, O14687	Gene names	MLL2, ALR
Domain Architecture
Description	Myeloid/lymphoid or mixed-lineage leukemia protein 2 (ALL1-related protein).

SPR1B_HUMAN
NC score	0.039827 (rank : 16)	θ value	1.38821 (rank : 31)
Query Neighborhood Hits	89	Target Neighborhood Hits	102	Shared Neighborhood Hits	8
SwissProt Accessions	P22528, P22529, P22530, Q5T524	Gene names	SPRR1B
Domain Architecture	No domain graphic available
Description	Cornifin B (Small proline-rich protein IB) (SPR-IB) (14.9 kDa pancornulin).

VGLL1_HUMAN
NC score	0.038494 (rank : 17)	θ value	1.81305 (rank : 38)
Query Neighborhood Hits	89	Target Neighborhood Hits	12	Shared Neighborhood Hits	2
SwissProt Accessions	Q99990	Gene names	VGLL1, TDU
Domain Architecture	No domain graphic available
Description	Transcription cofactor vestigial-like protein 1 (Vgl-1) (Protein TONDU).

BARD1_MOUSE
NC score	0.038075 (rank : 18)	θ value	5.27518 (rank : 61)
Query Neighborhood Hits	89	Target Neighborhood Hits	411	Shared Neighborhood Hits	12
SwissProt Accessions	O70445	Gene names	Bard1
Domain Architecture
Description	BRCA1-associated RING domain protein 1 (BARD-1).

ZHX2_HUMAN
NC score	0.037704 (rank : 19)	θ value	0.0961366 (rank : 10)
Query Neighborhood Hits	89	Target Neighborhood Hits	347	Shared Neighborhood Hits	7
SwissProt Accessions	Q9Y6X8	Gene names	ZHX2, AFR1, KIAA0854, RAF
Domain Architecture
Description	Zinc fingers and homeoboxes protein 2 (Zinc finger and homeodomain protein 2) (Alpha-fetoprotein regulator 1) (AFP regulator 1) (Regulator of AFP).

SON_HUMAN
NC score	0.035751 (rank : 20)	θ value	0.125558 (rank : 13)
Query Neighborhood Hits	89	Target Neighborhood Hits	1568	Shared Neighborhood Hits	39
SwissProt Accessions	P18583, O14487, O95981, Q14120, Q9H7B1, Q9P070, Q9P072, Q9UKP9, Q9UPY0	Gene names	SON, C21orf50, DBP5, KIAA1019, NREBP
Domain Architecture
Description	SON protein (SON3) (Negative regulatory element-binding protein) (NRE- binding protein) (DBP-5) (Bax antagonist selected in saccharomyces 1) (BASS1).

BAZ1B_HUMAN
NC score	0.035025 (rank : 21)	θ value	0.47712 (rank : 16)
Query Neighborhood Hits	89	Target Neighborhood Hits	701	Shared Neighborhood Hits	15
SwissProt Accessions	Q9UIG0, O95039, O95247, O95277	Gene names	BAZ1B, WBSC10, WBSCR9, WSTF
Domain Architecture
Description	Bromodomain adjacent to zinc finger domain protein 1B (Williams-Beuren syndrome chromosome region 9 protein) (Williams syndrome transcription factor) (hWALP2).

LAMP1_HUMAN
NC score	0.033149 (rank : 22)	θ value	1.06291 (rank : 25)
Query Neighborhood Hits	89	Target Neighborhood Hits	18	Shared Neighborhood Hits	2
SwissProt Accessions	P11279	Gene names	LAMP1
Domain Architecture
Description	Lysosome-associated membrane glycoprotein 1 precursor (LAMP-1) (CD107a antigen).

SPR1B_MOUSE
NC score	0.032885 (rank : 23)	θ value	1.06291 (rank : 26)
Query Neighborhood Hits	89	Target Neighborhood Hits	395	Shared Neighborhood Hits	20
SwissProt Accessions	Q62267	Gene names	Sprr1b
Domain Architecture
Description	Cornifin B (Small proline-rich protein 1B) (SPR1B) (SPR1 B).

K1949_MOUSE
NC score	0.032764 (rank : 24)	θ value	1.81305 (rank : 36)
Query Neighborhood Hits	89	Target Neighborhood Hits	134	Shared Neighborhood Hits	8
SwissProt Accessions	Q8BQ30, Q3UDS6, Q8CEY9, Q8R3D8	Gene names
Domain Architecture	No domain graphic available
Description	Protein KIAA1949 homolog.

SNX19_HUMAN
NC score	0.032193 (rank : 25)	θ value	2.36792 (rank : 43)
Query Neighborhood Hits	89	Target Neighborhood Hits	123	Shared Neighborhood Hits	5
SwissProt Accessions	Q92543	Gene names	SNX19, KIAA0254
Domain Architecture
Description	Sorting nexin-19.

CS016_HUMAN
NC score	0.031513 (rank : 26)	θ value	6.88961 (rank : 65)
Query Neighborhood Hits	89	Target Neighborhood Hits	310	Shared Neighborhood Hits	19
SwissProt Accessions	Q8ND99	Gene names	C19orf16
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C19orf16.

EP400_MOUSE
NC score	0.031077 (rank : 27)	θ value	0.62314 (rank : 20)
Query Neighborhood Hits	89	Target Neighborhood Hits	592	Shared Neighborhood Hits	18
SwissProt Accessions	Q8CHI8, Q80TC8, Q8BXI5, Q8BYW3, Q8C0P6, Q8CHI7, Q8VDF4, Q9DA54	Gene names	Ep400, Kiaa1498
Domain Architecture	No domain graphic available
Description	E1A-binding protein p400 (EC 3.6.1.-) (p400 kDa SWI2/SNF2-related protein) (Domino homolog) (mDomino).

BAZ1B_MOUSE
NC score	0.030764 (rank : 28)	θ value	2.36792 (rank : 40)
Query Neighborhood Hits	89	Target Neighborhood Hits	394	Shared Neighborhood Hits	8
SwissProt Accessions	Q9Z277, Q9CU68	Gene names	Baz1b, Wbscr9
Domain Architecture
Description	Bromodomain adjacent to zinc finger domain protein 1B (Williams-Beuren syndrome chromosome region 9 protein homolog) (WBRS9).

EP400_HUMAN
NC score	0.028959 (rank : 29)	θ value	2.36792 (rank : 41)
Query Neighborhood Hits	89	Target Neighborhood Hits	556	Shared Neighborhood Hits	21
SwissProt Accessions	Q96L91, O15411, Q6P2F5, Q8N8Q7, Q8NE05, Q96JK7, Q9P230	Gene names	EP400, CAGH32, KIAA1498, KIAA1818, TNRC12
Domain Architecture	No domain graphic available
Description	E1A-binding protein p400 (EC 3.6.1.-) (p400 kDa SWI2/SNF2-related protein) (Domino homolog) (hDomino) (CAG repeat protein 32) (Trinucleotide repeat-containing gene 12 protein).

MLL4_HUMAN
NC score	0.027283 (rank : 30)	θ value	3.0926 (rank : 49)
Query Neighborhood Hits	89	Target Neighborhood Hits	722	Shared Neighborhood Hits	27
SwissProt Accessions	Q9UMN6, O15022, O95836, Q96GP2, Q96IP3, Q9UK25, Q9Y668, Q9Y669	Gene names	MLL4, HRX2, KIAA0304, MLL2, TRX2
Domain Architecture
Description	Myeloid/lymphoid or mixed-lineage leukemia protein 4 (Trithorax homolog 2).

SF3A1_HUMAN
NC score	0.026201 (rank : 31)	θ value	6.88961 (rank : 73)
Query Neighborhood Hits	89	Target Neighborhood Hits	199	Shared Neighborhood Hits	12
SwissProt Accessions	Q15459	Gene names	SF3A1, SAP114
Domain Architecture
Description	Splicing factor 3 subunit 1 (Spliceosome-associated protein 114) (SAP 114) (SF3a120).

ST5_HUMAN
NC score	0.025897 (rank : 32)	θ value	0.47712 (rank : 18)
Query Neighborhood Hits	89	Target Neighborhood Hits	151	Shared Neighborhood Hits	6
SwissProt Accessions	P78524, P78523, Q16492, Q7KYY2, Q7KZ12, Q8NE12, Q9BQQ6	Gene names	ST5, DENND2B, HTS1
Domain Architecture	No domain graphic available
Description	Suppression of tumorigenicity 5 (HeLa tumor suppression 1) (DENN domain-containing protein 2B).

STAR8_HUMAN
NC score	0.025847 (rank : 33)	θ value	0.62314 (rank : 21)
Query Neighborhood Hits	89	Target Neighborhood Hits	216	Shared Neighborhood Hits	10
SwissProt Accessions	Q92502, Q5JST0	Gene names	STARD8, KIAA0189
Domain Architecture
Description	StAR-related lipid transfer protein 8 (StARD8) (START domain- containing protein 8).

SF3A1_MOUSE
NC score	0.025846 (rank : 34)	θ value	6.88961 (rank : 74)
Query Neighborhood Hits	89	Target Neighborhood Hits	198	Shared Neighborhood Hits	11
SwissProt Accessions	Q8K4Z5, Q8C0M7, Q8C128, Q8C175, Q921T3	Gene names	Sf3a1
Domain Architecture	No domain graphic available
Description	Splicing factor 3 subunit 1 (SF3a120).

CCDC9_HUMAN
NC score	0.025540 (rank : 35)	θ value	4.03905 (rank : 51)
Query Neighborhood Hits	89	Target Neighborhood Hits	175	Shared Neighborhood Hits	9
SwissProt Accessions	Q9Y3X0	Gene names	CCDC9
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 9.

OGFR_HUMAN
NC score	0.024920 (rank : 36)	θ value	3.0926 (rank : 50)
Query Neighborhood Hits	89	Target Neighborhood Hits	1582	Shared Neighborhood Hits	46
SwissProt Accessions	Q9NZT2, O96029, Q4VXW5, Q96CM2, Q9BQW1, Q9H4H0, Q9H7J5, Q9NZT3, Q9NZT4	Gene names	OGFR
Domain Architecture
Description	Opioid growth factor receptor (OGFr) (Zeta-type opioid receptor) (7-60 protein).

CASB_MOUSE
NC score	0.024881 (rank : 37)	θ value	6.88961 (rank : 64)
Query Neighborhood Hits	89	Target Neighborhood Hits	18	Shared Neighborhood Hits	3
SwissProt Accessions	P10598, Q543D9, Q8VCT6, Q8VCU8, Q91VI5, Q922Y5, Q9D1U6, Q9D1U7	Gene names	Csn2, Csnb
Domain Architecture
Description	Beta-casein precursor.

SMC2_HUMAN
NC score	0.024576 (rank : 38)	θ value	0.21417 (rank : 14)
Query Neighborhood Hits	89	Target Neighborhood Hits	1405	Shared Neighborhood Hits	21
SwissProt Accessions	O95347, Q9P1P2	Gene names	SMC2L1, CAPE, SMC2
Domain Architecture
Description	Structural maintenance of chromosome 2-like 1 protein (Chromosome- associated protein E) (hCAP-E) (XCAP-E homolog).

K1802_MOUSE
NC score	0.023869 (rank : 39)	θ value	1.81305 (rank : 35)
Query Neighborhood Hits	89	Target Neighborhood Hits	1596	Shared Neighborhood Hits	39
SwissProt Accessions	Q8K327, Q3UZ85, Q6ZPI1	Gene names	Kiaa1802, D8Ertd457e
Domain Architecture	No domain graphic available
Description	Zinc finger protein KIAA1802.

ASPP2_HUMAN
NC score	0.023534 (rank : 40)	θ value	1.81305 (rank : 33)
Query Neighborhood Hits	89	Target Neighborhood Hits	1156	Shared Neighborhood Hits	26
SwissProt Accessions	Q13625, Q12892, Q86X75, Q96KQ3	Gene names	TP53BP2, ASPP2, BBP
Domain Architecture
Description	Apoptosis-stimulating of p53 protein 2 (Tumor suppressor p53-binding protein 2) (p53-binding protein 2) (p53BP2) (53BP2) (Bcl2-binding protein) (Bbp) (NY-REN-51 antigen).

CTDP1_MOUSE
NC score	0.023524 (rank : 41)	θ value	3.0926 (rank : 45)
Query Neighborhood Hits	89	Target Neighborhood Hits	146	Shared Neighborhood Hits	5
SwissProt Accessions	Q7TSG2, Q7TSS7, Q9D4S8	Gene names	Ctdp1, Fcp1
Domain Architecture
Description	RNA polymerase II subunit A C-terminal domain phosphatase (EC 3.1.3.16) (TFIIF-associating CTD phosphatase).

HD_HUMAN
NC score	0.022815 (rank : 42)	θ value	3.0926 (rank : 48)
Query Neighborhood Hits	89	Target Neighborhood Hits	165	Shared Neighborhood Hits	9
SwissProt Accessions	P42858, Q9UQB7	Gene names	HD, IT15
Domain Architecture
Description	Huntingtin (Huntington disease protein) (HD protein).

ASPP1_MOUSE
NC score	0.022619 (rank : 43)	θ value	5.27518 (rank : 60)
Query Neighborhood Hits	89	Target Neighborhood Hits	1244	Shared Neighborhood Hits	39
SwissProt Accessions	Q62415	Gene names	Ppp1r13b, Aspp1
Domain Architecture
Description	Apoptosis-stimulating of p53 protein 1 (Protein phosphatase 1 regulatory subunit 13B).

MDC1_MOUSE
NC score	0.022476 (rank : 44)	θ value	8.99809 (rank : 84)
Query Neighborhood Hits	89	Target Neighborhood Hits	998	Shared Neighborhood Hits	33
SwissProt Accessions	Q5PSV9, Q5U4D3, Q6ZQH7	Gene names	Mdc1, Kiaa0170
Domain Architecture	No domain graphic available
Description	Mediator of DNA damage checkpoint protein 1.

MINT_MOUSE
NC score	0.022331 (rank : 45)	θ value	1.81305 (rank : 37)
Query Neighborhood Hits	89	Target Neighborhood Hits	1514	Shared Neighborhood Hits	34
SwissProt Accessions	Q62504, Q80TN9, Q99PS4, Q9QZW2	Gene names	Spen, Kiaa0929, Mint, Sharp
Domain Architecture
Description	Msx2-interacting protein (SPEN homolog) (SMART/HDAC1-associated repressor protein).

RTN1_MOUSE
NC score	0.022183 (rank : 46)	θ value	2.36792 (rank : 42)
Query Neighborhood Hits	89	Target Neighborhood Hits	189	Shared Neighborhood Hits	12
SwissProt Accessions	Q8K0T0, Q8K4S4	Gene names	Rtn1, Nsp
Domain Architecture	No domain graphic available
Description	Reticulon-1 (Neuroendocrine-specific protein).

ZEP1_HUMAN
NC score	0.021574 (rank : 47)	θ value	0.0961366 (rank : 9)
Query Neighborhood Hits	89	Target Neighborhood Hits	1036	Shared Neighborhood Hits	18
SwissProt Accessions	P15822, Q14122	Gene names	HIVEP1, ZNF40
Domain Architecture	No domain graphic available
Description	Zinc finger protein 40 (Human immunodeficiency virus type I enhancer- binding protein 1) (HIV-EP1) (Major histocompatibility complex-binding protein 1) (MBP-1) (Positive regulatory domain II-binding factor 1) (PRDII-BF1).

CSKI2_MOUSE
NC score	0.020876 (rank : 48)	θ value	0.813845 (rank : 22)
Query Neighborhood Hits	89	Target Neighborhood Hits	812	Shared Neighborhood Hits	19
SwissProt Accessions	Q8VHK1, Q6ZPX1, Q7TS77	Gene names	Caskin2, Kiaa1139
Domain Architecture	No domain graphic available
Description	Caskin-2.

KCNK4_MOUSE
NC score	0.020357 (rank : 49)	θ value	1.38821 (rank : 28)
Query Neighborhood Hits	89	Target Neighborhood Hits	118	Shared Neighborhood Hits	4
SwissProt Accessions	O88454	Gene names	Kcnk4, Traak
Domain Architecture	No domain graphic available
Description	Potassium channel subfamily K member 4 (TWIK-related arachidonic acid- stimulated potassium channel protein) (TRAAK).

P53_HUMAN
NC score	0.020261 (rank : 50)	θ value	4.03905 (rank : 55)
Query Neighborhood Hits	89	Target Neighborhood Hits	42	Shared Neighborhood Hits	6
SwissProt Accessions	P04637, Q15086, Q15087, Q15088, Q16535, Q16807, Q16808, Q16809, Q16810, Q16811, Q16848, Q86UG1, Q8J016, Q99659, Q9BTM4, Q9HAQ8, Q9NP68, Q9NPJ2, Q9NZD0, Q9UBI2, Q9UQ61	Gene names	TP53, P53
Domain Architecture
Description	Cellular tumor antigen p53 (Tumor suppressor p53) (Phosphoprotein p53) (Antigen NY-CO-13).

BL1S3_HUMAN
NC score	0.019998 (rank : 51)	θ value	8.99809 (rank : 79)
Query Neighborhood Hits	89	Target Neighborhood Hits	17	Shared Neighborhood Hits	3
SwissProt Accessions	Q6QNY0	Gene names	BLOC1S3, BLOS3
Domain Architecture	No domain graphic available
Description	Biogenesis of lysosome-related organelles complex-1 subunit 3 (BLOC subunit 3).

DEN1A_HUMAN
NC score	0.019944 (rank : 52)	θ value	6.88961 (rank : 67)
Query Neighborhood Hits	89	Target Neighborhood Hits	176	Shared Neighborhood Hits	11
SwissProt Accessions	Q8TEH3, Q5VWF0, Q8IVD6, Q9H796	Gene names	DENND1A
Domain Architecture	No domain graphic available
Description	DENN domain-containing protein 1A.

PER3_HUMAN
NC score	0.019457 (rank : 53)	θ value	4.03905 (rank : 56)
Query Neighborhood Hits	89	Target Neighborhood Hits	479	Shared Neighborhood Hits	21
SwissProt Accessions	P56645, Q5H8X4, Q969K6, Q96S77, Q96S78, Q9C0J3, Q9NSP9, Q9UGU8	Gene names	PER3
Domain Architecture
Description	Period circadian protein 3 (hPER3).

ACINU_MOUSE
NC score	0.018690 (rank : 54)	θ value	8.99809 (rank : 77)
Query Neighborhood Hits	89	Target Neighborhood Hits	712	Shared Neighborhood Hits	23
SwissProt Accessions	Q9JIX8, Q9CSN7, Q9CSR9, Q9CSX7, Q9R046, Q9R047	Gene names	Acin1, Acinus
Domain Architecture
Description	Apoptotic chromatin condensation inducer in the nucleus (Acinus).

BPA1_MOUSE
NC score	0.018340 (rank : 55)	θ value	0.125558 (rank : 12)
Query Neighborhood Hits	89	Target Neighborhood Hits	1477	Shared Neighborhood Hits	19
SwissProt Accessions	Q91ZU6, Q91ZU7	Gene names	Dst, Bpag1
Domain Architecture
Description	Bullous pemphigoid antigen 1, isoforms 1/2/3/4 (BPA) (Hemidesmosomal plaque protein) (Dystonia musculorum protein) (Dystonin).

DREB_HUMAN
NC score	0.017153 (rank : 56)	θ value	6.88961 (rank : 68)
Query Neighborhood Hits	89	Target Neighborhood Hits	450	Shared Neighborhood Hits	13
SwissProt Accessions	Q16643	Gene names	DBN1
Domain Architecture
Description	Drebrin (Developmentally-regulated brain protein).

CSKI1_HUMAN
NC score	0.017134 (rank : 57)	θ value	6.88961 (rank : 66)
Query Neighborhood Hits	89	Target Neighborhood Hits	997	Shared Neighborhood Hits	30
SwissProt Accessions	Q8WXD9, Q9P2P0	Gene names	CASKIN1, KIAA1306
Domain Architecture	No domain graphic available
Description	Caskin-1 (CASK-interacting protein 1).

ANK2_HUMAN
NC score	0.016752 (rank : 58)	θ value	3.0926 (rank : 44)
Query Neighborhood Hits	89	Target Neighborhood Hits	1615	Shared Neighborhood Hits	39
SwissProt Accessions	Q01484, Q01485	Gene names	ANK2
Domain Architecture
Description	Ankyrin-2 (Brain ankyrin) (Ankyrin-B) (Ankyrin, nonerythroid).

STAR8_MOUSE
NC score	0.016436 (rank : 59)	θ value	8.99809 (rank : 86)
Query Neighborhood Hits	89	Target Neighborhood Hits	101	Shared Neighborhood Hits	3
SwissProt Accessions	Q8K031, Q3UZC7, Q6A0A8, Q6P5E0, Q8R3X8	Gene names	Stard8, Kiaa0189
Domain Architecture	No domain graphic available
Description	StAR-related lipid transfer protein 8 (StARD8) (START domain- containing protein 8).

TACC2_MOUSE
NC score	0.016302 (rank : 60)	θ value	5.27518 (rank : 62)
Query Neighborhood Hits	89	Target Neighborhood Hits	774	Shared Neighborhood Hits	20
SwissProt Accessions	Q9JJG0	Gene names	Tacc2
Domain Architecture
Description	Transforming acidic coiled-coil-containing protein 2.

TRXR1_HUMAN
NC score	0.016252 (rank : 61)	θ value	5.27518 (rank : 63)
Query Neighborhood Hits	89	Target Neighborhood Hits	20	Shared Neighborhood Hits	3
SwissProt Accessions	Q16881, Q76P53, Q7LA96, Q9UH79	Gene names	TXNRD1
Domain Architecture
Description	Thioredoxin reductase 1, cytoplasmic precursor (EC 1.8.1.9) (TR) (TR1).

ZN198_HUMAN
NC score	0.015587 (rank : 62)	θ value	4.03905 (rank : 58)
Query Neighborhood Hits	89	Target Neighborhood Hits	128	Shared Neighborhood Hits	2
SwissProt Accessions	Q9UBW7, O43212, O43434, O60898, Q5W0Q4, Q63HP0, Q8NE39, Q9H538, Q9UEU2	Gene names	ZNF198, FIM, RAMP, ZMYM2
Domain Architecture
Description	Zinc finger protein 198 (Zinc finger MYM-type protein 2) (Fused in myeloproliferative disorders protein) (Rearranged in atypical myeloproliferative disorder protein).

ZO1_HUMAN
NC score	0.015059 (rank : 63)	θ value	1.38821 (rank : 32)
Query Neighborhood Hits	89	Target Neighborhood Hits	474	Shared Neighborhood Hits	6
SwissProt Accessions	Q07157, Q4ZGJ6	Gene names	TJP1, ZO1
Domain Architecture
Description	Tight junction protein ZO-1 (Zonula occludens 1 protein) (Zona occludens 1 protein) (Tight junction protein 1).

TRXR1_MOUSE
NC score	0.013875 (rank : 64)	θ value	8.99809 (rank : 87)
Query Neighborhood Hits	89	Target Neighborhood Hits	16	Shared Neighborhood Hits	3
SwissProt Accessions	Q9JMH6	Gene names	Txnrd1, Trxr1
Domain Architecture
Description	Thioredoxin reductase 1, cytoplasmic (EC 1.8.1.9) (TR) (TR1).

REPS2_HUMAN
NC score	0.013445 (rank : 65)	θ value	6.88961 (rank : 72)
Query Neighborhood Hits	89	Target Neighborhood Hits	131	Shared Neighborhood Hits	7
SwissProt Accessions	Q8NFH8, O43428, Q8NFI5	Gene names	REPS2, POB1
Domain Architecture
Description	RalBP1-associated Eps domain-containing protein 2 (RalBP1-interacting protein 2) (Partner of RalBP1).

CNGB1_HUMAN
NC score	0.012819 (rank : 66)	θ value	4.03905 (rank : 54)
Query Neighborhood Hits	89	Target Neighborhood Hits	222	Shared Neighborhood Hits	12
SwissProt Accessions	Q14028, Q14029	Gene names	CNGB1, CNCG4
Domain Architecture
Description	Cyclic nucleotide-gated cation channel 4 (CNG channel 4) (CNG-4) (CNG4) (Cyclic nucleotide-gated cation channel modulatory subunit).

SC24C_HUMAN
NC score	0.012034 (rank : 67)	θ value	8.99809 (rank : 85)
Query Neighborhood Hits	89	Target Neighborhood Hits	662	Shared Neighborhood Hits	15
SwissProt Accessions	P53992, Q8WV25	Gene names	SEC24C, KIAA0079
Domain Architecture
Description	Protein transport protein Sec24C (SEC24-related protein C).

EVX1_HUMAN
NC score	0.011312 (rank : 68)	θ value	3.0926 (rank : 46)
Query Neighborhood Hits	89	Target Neighborhood Hits	349	Shared Neighborhood Hits	6
SwissProt Accessions	P49640	Gene names	EVX1
Domain Architecture
Description	Homeobox even-skipped homolog protein 1 (EVX-1).

NFM_HUMAN
NC score	0.011143 (rank : 69)	θ value	0.813845 (rank : 23)
Query Neighborhood Hits	89	Target Neighborhood Hits	1328	Shared Neighborhood Hits	28
SwissProt Accessions	P07197	Gene names	NEF3, NEFM, NFM
Domain Architecture
Description	Neurofilament triplet M protein (160 kDa neurofilament protein) (Neurofilament medium polypeptide) (NF-M) (Neurofilament 3).

EVX1_MOUSE
NC score	0.011044 (rank : 70)	θ value	3.0926 (rank : 47)
Query Neighborhood Hits	89	Target Neighborhood Hits	350	Shared Neighborhood Hits	5
SwissProt Accessions	P23683	Gene names	Evx1
Domain Architecture
Description	Homeobox even-skipped homolog protein 1 (EVX-1).

ATBF1_MOUSE
NC score	0.011031 (rank : 71)	θ value	8.99809 (rank : 78)
Query Neighborhood Hits	89	Target Neighborhood Hits	1841	Shared Neighborhood Hits	37
SwissProt Accessions	Q61329	Gene names	Atbf1
Domain Architecture
Description	Alpha-fetoprotein enhancer-binding protein (AT motif-binding factor) (AT-binding transcription factor 1).

KNTC2_MOUSE
NC score	0.010207 (rank : 72)	θ value	6.88961 (rank : 71)
Query Neighborhood Hits	89	Target Neighborhood Hits	692	Shared Neighborhood Hits	9
SwissProt Accessions	Q9D0F1, Q3TQT6, Q3UWM5, Q99P70	Gene names	Kntc2, Hec1
Domain Architecture	No domain graphic available
Description	Kinetochore protein Hec1 (Kinetochore-associated protein 2).

CSPG3_MOUSE
NC score	0.009781 (rank : 73)	θ value	1.81305 (rank : 34)
Query Neighborhood Hits	89	Target Neighborhood Hits	657	Shared Neighborhood Hits	8
SwissProt Accessions	P55066, Q6P1E3, Q8C4F8	Gene names	Cspg3, Ncan
Domain Architecture
Description	Neurocan core protein precursor (Chondroitin sulfate proteoglycan 3).

ZF106_HUMAN
NC score	0.008941 (rank : 74)	θ value	8.99809 (rank : 89)
Query Neighborhood Hits	89	Target Neighborhood Hits	470	Shared Neighborhood Hits	14
SwissProt Accessions	Q9H2Y7, Q6NSD9, Q6PEK1, Q86T43, Q86T45, Q86T50, Q86T58, Q86TA9, Q96M37, Q9H7B8	Gene names	ZFP106, ZNF474
Domain Architecture	No domain graphic available
Description	Zinc finger protein 106 homolog (Zfp-106) (Zinc finger protein 474).

VINEX_MOUSE
NC score	0.008367 (rank : 75)	θ value	6.88961 (rank : 76)
Query Neighborhood Hits	89	Target Neighborhood Hits	286	Shared Neighborhood Hits	4
SwissProt Accessions	Q9R1Z8, Q62423	Gene names	Sorbs3, Scam1, Sh3d4
Domain Architecture
Description	Vinexin (Sorbin and SH3 domain-containing protein 3) (SH3-containing adapter molecule 1) (SCAM-1) (SH3 domain-containing protein SH3P3).

HIC1_MOUSE
NC score	0.008260 (rank : 76)	θ value	0.47712 (rank : 17)
Query Neighborhood Hits	89	Target Neighborhood Hits	863	Shared Neighborhood Hits	16
SwissProt Accessions	Q9R1Y5, Q9R1Y6, Q9R2B0	Gene names	Hic1
Domain Architecture
Description	Hypermethylated in cancer 1 protein (Hic-1).

JHD3B_HUMAN
NC score	0.007841 (rank : 77)	θ value	8.99809 (rank : 82)
Query Neighborhood Hits	89	Target Neighborhood Hits	128	Shared Neighborhood Hits	8
SwissProt Accessions	O94953, O75274, Q6P3R5, Q9P1V1, Q9UF40	Gene names	JMJD2B, JHDM3B, KIAA0876
Domain Architecture
Description	JmjC domain-containing histone demethylation protein 3B (EC 1.14.11.-) (Jumonji domain-containing protein 2B).

GRAP1_MOUSE
NC score	0.007360 (rank : 78)	θ value	6.88961 (rank : 70)
Query Neighborhood Hits	89	Target Neighborhood Hits	1234	Shared Neighborhood Hits	16
SwissProt Accessions	Q8VD04, O35693, Q3T9C3, Q69ZP9	Gene names	Gripap1, DXImx47e, Kiaa1167
Domain Architecture	No domain graphic available
Description	GRIP1-associated protein 1 (GRASP-1) (HCMV-interacting protein).

OBSCN_HUMAN
NC score	0.007253 (rank : 79)	θ value	0.813845 (rank : 24)
Query Neighborhood Hits	89	Target Neighborhood Hits	1931	Shared Neighborhood Hits	24
SwissProt Accessions	Q5VST9, Q2A664, Q5T7G8, Q5T7G9, Q5VSU2, Q86YC7, Q8NHN0, Q8NHN1, Q8NHN2, Q8NHN4, Q8NHN5, Q8NHN6, Q8NHN7, Q8NHN8, Q8NHN9, Q96AA2, Q9HCD3, Q9HCL6	Gene names	OBSCN, KIAA1556, KIAA1639
Domain Architecture	No domain graphic available
Description	Obscurin (Obscurin-myosin light chain kinase) (Obscurin-MLCK) (Obscurin-RhoGEF).

TITIN_HUMAN
NC score	0.007199 (rank : 80)	θ value	4.03905 (rank : 57)
Query Neighborhood Hits	89	Target Neighborhood Hits	2923	Shared Neighborhood Hits	38
SwissProt Accessions	Q8WZ42, Q10465, Q10466, Q15598, Q2XUS3, Q32Q60, Q4U1Z6, Q6NSG0, Q6PDB1, Q6PJP0, Q7KYM2, Q7KYN4, Q7KYN5, Q7LDM3, Q7Z2X3, Q8TCG8, Q8WZ51, Q8WZ52, Q8WZ53, Q8WZB3, Q92761, Q92762, Q9UD97, Q9UP84, Q9Y6L9	Gene names	TTN
Domain Architecture	No domain graphic available
Description	Titin (EC 2.7.11.1) (Connectin) (Rhabdomyosarcoma antigen MU-RMS- 40.14).

GPR64_HUMAN
NC score	0.006984 (rank : 81)	θ value	6.88961 (rank : 69)
Query Neighborhood Hits	89	Target Neighborhood Hits	207	Shared Neighborhood Hits	8
SwissProt Accessions	Q8IZP9, O00406, Q8IWT2, Q8IZE4, Q8IZE5, Q8IZE6, Q8IZE7, Q8IZP3, Q8IZP4	Gene names	GPR64, HE6, TM7LN2
Domain Architecture
Description	G-protein coupled receptor 64 precursor (Epididymis-specific protein 6) (He6 receptor).

HIC1_HUMAN
NC score	0.006715 (rank : 82)	θ value	1.38821 (rank : 27)
Query Neighborhood Hits	89	Target Neighborhood Hits	838	Shared Neighborhood Hits	11
SwissProt Accessions	Q14526	Gene names	HIC1, ZBTB29
Domain Architecture
Description	Hypermethylated in cancer 1 protein (Hic-1) (Zinc finger and BTB domain-containing protein 29).

ZN507_HUMAN
NC score	0.006620 (rank : 83)	θ value	1.81305 (rank : 39)
Query Neighborhood Hits	89	Target Neighborhood Hits	739	Shared Neighborhood Hits	8
SwissProt Accessions	Q8TCN5	Gene names	ZNF507
Domain Architecture	No domain graphic available
Description	Zinc finger protein 507.

UBP43_HUMAN
NC score	0.006561 (rank : 84)	θ value	8.99809 (rank : 88)
Query Neighborhood Hits	89	Target Neighborhood Hits	144	Shared Neighborhood Hits	5
SwissProt Accessions	Q70EL4, Q8N2C5, Q96DQ6	Gene names	USP43
Domain Architecture	No domain graphic available
Description	Ubiquitin carboxyl-terminal hydrolase 43 (EC 3.1.2.15) (Ubiquitin thioesterase 43) (Ubiquitin-specific-processing protease 43) (Deubiquitinating enzyme 43).

GRIK1_MOUSE
NC score	0.006395 (rank : 85)	θ value	8.99809 (rank : 81)
Query Neighborhood Hits	89	Target Neighborhood Hits	46	Shared Neighborhood Hits	3
SwissProt Accessions	Q60934	Gene names	Grik1, Glur5
Domain Architecture
Description	Glutamate receptor, ionotropic kainate 1 precursor (Glutamate receptor 5) (GluR-5) (GluR5).

GRIK1_HUMAN
NC score	0.005928 (rank : 86)	θ value	8.99809 (rank : 80)
Query Neighborhood Hits	89	Target Neighborhood Hits	48	Shared Neighborhood Hits	3
SwissProt Accessions	P39086, Q13001, Q86SU9	Gene names	GRIK1, GLUR5
Domain Architecture
Description	Glutamate receptor, ionotropic kainate 1 precursor (Glutamate receptor 5) (GluR-5) (GluR5) (Excitatory amino acid receptor 3) (EAA3).

UDB10_HUMAN
NC score	0.005147 (rank : 87)	θ value	6.88961 (rank : 75)
Query Neighborhood Hits	89	Target Neighborhood Hits	29	Shared Neighborhood Hits	2
SwissProt Accessions	P36537	Gene names	UGT2B10
Domain Architecture
Description	UDP-glucuronosyltransferase 2B10 precursor (EC 2.4.1.17) (UDPGT).

ACRO_HUMAN
NC score	0.004251 (rank : 88)	θ value	5.27518 (rank : 59)
Query Neighborhood Hits	89	Target Neighborhood Hits	291	Shared Neighborhood Hits	11
SwissProt Accessions	P10323, Q6ICK2	Gene names	ACR, ACRS
Domain Architecture
Description	Acrosin precursor (EC 3.4.21.10) [Contains: Acrosin light chain; Acrosin heavy chain].

CD2L5_MOUSE
NC score	0.003774 (rank : 89)	θ value	4.03905 (rank : 53)
Query Neighborhood Hits	89	Target Neighborhood Hits	1011	Shared Neighborhood Hits	10
SwissProt Accessions	Q69ZA1, Q80V11, Q8BZG1, Q8K0A4	Gene names	Cdc2l5, Kiaa1791
Domain Architecture	No domain graphic available
Description	Cell division cycle 2-like protein kinase 5 (EC 2.7.11.22) (CDC2- related protein kinase 5).

CD2L5_HUMAN
NC score	0.003613 (rank : 90)	θ value	4.03905 (rank : 52)
Query Neighborhood Hits	89	Target Neighborhood Hits	987	Shared Neighborhood Hits	7
SwissProt Accessions	Q14004, Q6DKQ9, Q75MH4, Q75MH5, Q96JN4, Q9H4A0, Q9H4A1, Q9UDR4	Gene names	CDC2L5, CDC2L, CHED, KIAA1791
Domain Architecture
Description	Cell division cycle 2-like protein kinase 5 (EC 2.7.11.22) (CDC2- related protein kinase 5) (Cholinesterase-related cell division controller).

LAMA5_HUMAN
NC score	0.003304 (rank : 91)	θ value	8.99809 (rank : 83)
Query Neighborhood Hits	89	Target Neighborhood Hits	976	Shared Neighborhood Hits	12
SwissProt Accessions	O15230, Q8WZA7, Q9H1P1	Gene names	LAMA5, KIAA0533, KIAA1907
Domain Architecture
Description	Laminin alpha-5 chain precursor.