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Network neighborhood for query Sequence : ADPN_HUMAN

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ADPN_HUMAN
SwissProt Accessions	Q9NST1, Q6P1A1, Q96CB4	Gene names	PNPLA3, ADPN, C22orf20
Domain Architecture
Description	Adiponutrin (iPLA2-epsilon) (Calcium-independent phospholipase A2- epsilon) (Patatin-like phospholipase domain-containing protein 3) [Includes: Triacylglycerol lipase (EC 3.1.1.3); Acylglycerol O- acyltransferase (EC 2.3.1.-)].
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

ADPN_HUMAN
θ value	0 (rank : 1)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	11	Target Neighborhood Hits	11	Shared Neighborhood Hits	11
SwissProt Accessions	Q9NST1, Q6P1A1, Q96CB4	Gene names	PNPLA3, ADPN, C22orf20
Domain Architecture
Description	Adiponutrin (iPLA2-epsilon) (Calcium-independent phospholipase A2- epsilon) (Patatin-like phospholipase domain-containing protein 3) [Includes: Triacylglycerol lipase (EC 3.1.1.3); Acylglycerol O- acyltransferase (EC 2.3.1.-)].

ADPN_MOUSE
θ value	8.88953e-157 (rank : 2)	NC score	0.985532 (rank : 2)
Query Neighborhood Hits	11	Target Neighborhood Hits	4	Shared Neighborhood Hits	3
SwissProt Accessions	Q91WW7	Gene names	Pnpla3, Adpn
Domain Architecture
Description	Adiponutrin (iPLA2-epsilon) (Calcium-independent phospholipase A2- epsilon) (Patatin-like phospholipase domain-containing protein 3) [Includes: Triacylglycerol lipase (EC 3.1.1.3); Acylglycerol O- acyltransferase (EC 2.3.1.-)].

PLPL4_HUMAN
θ value	4.41421e-39 (rank : 3)	NC score	0.874185 (rank : 3)
Query Neighborhood Hits	11	Target Neighborhood Hits	5	Shared Neighborhood Hits	3
SwissProt Accessions	P41247, Q8WW83	Gene names	PNPLA4, DXS1283E, GS2
Domain Architecture
Description	Patatin-like phospholipase domain-containing protein 4 (Protein GS2).

TRXR2_HUMAN
θ value	0.125558 (rank : 4)	NC score	0.085834 (rank : 4)
Query Neighborhood Hits	11	Target Neighborhood Hits	18	Shared Neighborhood Hits	5
SwissProt Accessions	Q9NNW7, O95840, Q96IJ2, Q9H2Z5, Q9NZV3, Q9NZV4, Q9P2Y0, Q9P2Y1, Q9UQU8	Gene names	TXNRD2, TRXR2
Domain Architecture
Description	Thioredoxin reductase 2, mitochondrial precursor (EC 1.8.1.9) (TR3) (TR-beta) (Selenoprotein Z) (SelZ).

TRXR1_HUMAN
θ value	0.365318 (rank : 5)	NC score	0.082949 (rank : 5)
Query Neighborhood Hits	11	Target Neighborhood Hits	20	Shared Neighborhood Hits	5
SwissProt Accessions	Q16881, Q76P53, Q7LA96, Q9UH79	Gene names	TXNRD1
Domain Architecture
Description	Thioredoxin reductase 1, cytoplasmic precursor (EC 1.8.1.9) (TR) (TR1).

TRXR1_MOUSE
θ value	0.365318 (rank : 6)	NC score	0.082682 (rank : 6)
Query Neighborhood Hits	11	Target Neighborhood Hits	16	Shared Neighborhood Hits	5
SwissProt Accessions	Q9JMH6	Gene names	Txnrd1, Trxr1
Domain Architecture
Description	Thioredoxin reductase 1, cytoplasmic (EC 1.8.1.9) (TR) (TR1).

MCR_MOUSE
θ value	2.36792 (rank : 7)	NC score	0.011909 (rank : 10)
Query Neighborhood Hits	11	Target Neighborhood Hits	162	Shared Neighborhood Hits	2
SwissProt Accessions	Q8VII8, Q8VII9	Gene names	Nr3c2, Mlr
Domain Architecture	No domain graphic available
Description	Mineralocorticoid receptor (MR).

TRXR2_MOUSE
θ value	3.0926 (rank : 8)	NC score	0.072433 (rank : 7)
Query Neighborhood Hits	11	Target Neighborhood Hits	23	Shared Neighborhood Hits	5
SwissProt Accessions	Q9JLT4, Q91YX4, Q9JHA7, Q9JMH5	Gene names	Txnrd2, Trxr2
Domain Architecture
Description	Thioredoxin reductase 2, mitochondrial precursor (EC 1.8.1.9) (TR3).

HUTH_HUMAN
θ value	5.27518 (rank : 9)	NC score	0.022462 (rank : 8)
Query Neighborhood Hits	11	Target Neighborhood Hits	9	Shared Neighborhood Hits	2
SwissProt Accessions	P42357	Gene names	HAL, HIS
Domain Architecture
Description	Histidine ammonia-lyase (EC 4.3.1.3) (Histidase).

PCX3_MOUSE
θ value	6.88961 (rank : 10)	NC score	0.017380 (rank : 9)
Query Neighborhood Hits	11	Target Neighborhood Hits	134	Shared Neighborhood Hits	2
SwissProt Accessions	Q8VI59	Gene names	Pcnxl3
Domain Architecture
Description	Pecanex-like protein 3.

BAG3_HUMAN
θ value	8.99809 (rank : 11)	NC score	0.011194 (rank : 11)
Query Neighborhood Hits	11	Target Neighborhood Hits	314	Shared Neighborhood Hits	2
SwissProt Accessions	O95817, Q9NT20, Q9P120	Gene names	BAG3, BIS
Domain Architecture
Description	BAG family molecular chaperone regulator 3 (BCL-2-binding athanogene- 3) (BAG-3) (Bcl-2-binding protein Bis) (Docking protein CAIR-1).

Hits sorted by NC score

ADPN_HUMAN
NC score	0.999962 (rank : 1)	θ value	0 (rank : 1)
Query Neighborhood Hits	11	Target Neighborhood Hits	11	Shared Neighborhood Hits	11
SwissProt Accessions	Q9NST1, Q6P1A1, Q96CB4	Gene names	PNPLA3, ADPN, C22orf20
Domain Architecture
Description	Adiponutrin (iPLA2-epsilon) (Calcium-independent phospholipase A2- epsilon) (Patatin-like phospholipase domain-containing protein 3) [Includes: Triacylglycerol lipase (EC 3.1.1.3); Acylglycerol O- acyltransferase (EC 2.3.1.-)].

ADPN_MOUSE
NC score	0.985532 (rank : 2)	θ value	8.88953e-157 (rank : 2)
Query Neighborhood Hits	11	Target Neighborhood Hits	4	Shared Neighborhood Hits	3
SwissProt Accessions	Q91WW7	Gene names	Pnpla3, Adpn
Domain Architecture
Description	Adiponutrin (iPLA2-epsilon) (Calcium-independent phospholipase A2- epsilon) (Patatin-like phospholipase domain-containing protein 3) [Includes: Triacylglycerol lipase (EC 3.1.1.3); Acylglycerol O- acyltransferase (EC 2.3.1.-)].

PLPL4_HUMAN
NC score	0.874185 (rank : 3)	θ value	4.41421e-39 (rank : 3)
Query Neighborhood Hits	11	Target Neighborhood Hits	5	Shared Neighborhood Hits	3
SwissProt Accessions	P41247, Q8WW83	Gene names	PNPLA4, DXS1283E, GS2
Domain Architecture
Description	Patatin-like phospholipase domain-containing protein 4 (Protein GS2).

TRXR2_HUMAN
NC score	0.085834 (rank : 4)	θ value	0.125558 (rank : 4)
Query Neighborhood Hits	11	Target Neighborhood Hits	18	Shared Neighborhood Hits	5
SwissProt Accessions	Q9NNW7, O95840, Q96IJ2, Q9H2Z5, Q9NZV3, Q9NZV4, Q9P2Y0, Q9P2Y1, Q9UQU8	Gene names	TXNRD2, TRXR2
Domain Architecture
Description	Thioredoxin reductase 2, mitochondrial precursor (EC 1.8.1.9) (TR3) (TR-beta) (Selenoprotein Z) (SelZ).

TRXR1_HUMAN
NC score	0.082949 (rank : 5)	θ value	0.365318 (rank : 5)
Query Neighborhood Hits	11	Target Neighborhood Hits	20	Shared Neighborhood Hits	5
SwissProt Accessions	Q16881, Q76P53, Q7LA96, Q9UH79	Gene names	TXNRD1
Domain Architecture
Description	Thioredoxin reductase 1, cytoplasmic precursor (EC 1.8.1.9) (TR) (TR1).

TRXR1_MOUSE
NC score	0.082682 (rank : 6)	θ value	0.365318 (rank : 6)
Query Neighborhood Hits	11	Target Neighborhood Hits	16	Shared Neighborhood Hits	5
SwissProt Accessions	Q9JMH6	Gene names	Txnrd1, Trxr1
Domain Architecture
Description	Thioredoxin reductase 1, cytoplasmic (EC 1.8.1.9) (TR) (TR1).

TRXR2_MOUSE
NC score	0.072433 (rank : 7)	θ value	3.0926 (rank : 8)
Query Neighborhood Hits	11	Target Neighborhood Hits	23	Shared Neighborhood Hits	5
SwissProt Accessions	Q9JLT4, Q91YX4, Q9JHA7, Q9JMH5	Gene names	Txnrd2, Trxr2
Domain Architecture
Description	Thioredoxin reductase 2, mitochondrial precursor (EC 1.8.1.9) (TR3).

HUTH_HUMAN
NC score	0.022462 (rank : 8)	θ value	5.27518 (rank : 9)
Query Neighborhood Hits	11	Target Neighborhood Hits	9	Shared Neighborhood Hits	2
SwissProt Accessions	P42357	Gene names	HAL, HIS
Domain Architecture
Description	Histidine ammonia-lyase (EC 4.3.1.3) (Histidase).

PCX3_MOUSE
NC score	0.017380 (rank : 9)	θ value	6.88961 (rank : 10)
Query Neighborhood Hits	11	Target Neighborhood Hits	134	Shared Neighborhood Hits	2
SwissProt Accessions	Q8VI59	Gene names	Pcnxl3
Domain Architecture
Description	Pecanex-like protein 3.

MCR_MOUSE
NC score	0.011909 (rank : 10)	θ value	2.36792 (rank : 7)
Query Neighborhood Hits	11	Target Neighborhood Hits	162	Shared Neighborhood Hits	2
SwissProt Accessions	Q8VII8, Q8VII9	Gene names	Nr3c2, Mlr
Domain Architecture	No domain graphic available
Description	Mineralocorticoid receptor (MR).

BAG3_HUMAN
NC score	0.011194 (rank : 11)	θ value	8.99809 (rank : 11)
Query Neighborhood Hits	11	Target Neighborhood Hits	314	Shared Neighborhood Hits	2
SwissProt Accessions	O95817, Q9NT20, Q9P120	Gene names	BAG3, BIS
Domain Architecture
Description	BAG family molecular chaperone regulator 3 (BCL-2-binding athanogene- 3) (BAG-3) (Bcl-2-binding protein Bis) (Docking protein CAIR-1).