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Network neighborhood for query Sequence : DOK2_HUMAN

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DOK2_HUMAN
SwissProt Accessions	O60496	Gene names	DOK2
Domain Architecture
Description	Docking protein 2 (Downstream of tyrosine kinase 2) (p56(dok-2)).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

DOK2_HUMAN
θ value	0 (rank : 1)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	46	Target Neighborhood Hits	46	Shared Neighborhood Hits	46
SwissProt Accessions	O60496	Gene names	DOK2
Domain Architecture
Description	Docking protein 2 (Downstream of tyrosine kinase 2) (p56(dok-2)).

DOK2_MOUSE
θ value	5.36813e-170 (rank : 2)	NC score	0.928016 (rank : 2)
Query Neighborhood Hits	46	Target Neighborhood Hits	244	Shared Neighborhood Hits	22
SwissProt Accessions	O70469, O70272, Q99KL1	Gene names	Dok2, Frip
Domain Architecture
Description	Docking protein 2 (Downstream of tyrosine kinase 2) (p56(dok-2)) (Dok- related protein) (Dok-R) (IL-four receptor-interacting protein) (FRIP).

DOK3_HUMAN
θ value	5.20228e-48 (rank : 3)	NC score	0.890790 (rank : 4)
Query Neighborhood Hits	46	Target Neighborhood Hits	60	Shared Neighborhood Hits	19
SwissProt Accessions	Q7L591, Q8N864, Q9BQB3, Q9H666	Gene names	DOK3
Domain Architecture	No domain graphic available
Description	Docking protein 3 (Downstream of tyrosine kinase 3).

DOK1_HUMAN
θ value	2.58187e-47 (rank : 4)	NC score	0.883370 (rank : 6)
Query Neighborhood Hits	46	Target Neighborhood Hits	85	Shared Neighborhood Hits	18
SwissProt Accessions	Q99704, O43204, Q9UHG6	Gene names	DOK1
Domain Architecture
Description	Docking protein 1 (Downstream of tyrosine kinase 1) (p62(dok)) (pp62).

DOK1_MOUSE
θ value	4.122e-45 (rank : 5)	NC score	0.889051 (rank : 5)
Query Neighborhood Hits	46	Target Neighborhood Hits	82	Shared Neighborhood Hits	18
SwissProt Accessions	P97465, Q9R213	Gene names	Dok1, Dok
Domain Architecture
Description	Docking protein 1 (Downstream of tyrosine kinase 1) (p62(dok)).

DOK3_MOUSE
θ value	4.55743e-44 (rank : 6)	NC score	0.899447 (rank : 3)
Query Neighborhood Hits	46	Target Neighborhood Hits	25	Shared Neighborhood Hits	19
SwissProt Accessions	Q9QZK7	Gene names	Dok3, Dokl
Domain Architecture	No domain graphic available
Description	Docking protein 3 (Downstream of tyrosine kinase 3) (P62(dok)-like protein) (DOK-L).

DOK6_HUMAN
θ value	9.26847e-13 (rank : 7)	NC score	0.591871 (rank : 7)
Query Neighborhood Hits	46	Target Neighborhood Hits	25	Shared Neighborhood Hits	18
SwissProt Accessions	Q6PKX4, Q4V9S3, Q8WUZ8, Q96HI2, Q96LU2	Gene names	DOK6, DOK5L
Domain Architecture	No domain graphic available
Description	Docking protein 6 (Downstream of tyrosine kinase 6).

DOK5_HUMAN
θ value	1.133e-10 (rank : 8)	NC score	0.584501 (rank : 9)
Query Neighborhood Hits	46	Target Neighborhood Hits	28	Shared Neighborhood Hits	18
SwissProt Accessions	Q9P104, Q5T7Y0, Q5TE53, Q8TEW7, Q96H13, Q9BZ24, Q9NQF4, Q9Y411	Gene names	DOK5, C20orf180
Domain Architecture
Description	Docking protein 5 (Downstream of tyrosine kinase 5) (IRS6) (Protein dok-5).

DOK5_MOUSE
θ value	1.133e-10 (rank : 9)	NC score	0.585577 (rank : 8)
Query Neighborhood Hits	46	Target Neighborhood Hits	27	Shared Neighborhood Hits	18
SwissProt Accessions	Q91ZM9, Q8BRI3, Q9CSM6	Gene names	Dok5
Domain Architecture
Description	Docking protein 5 (Downstream of tyrosine kinase 5) (Protein dok-5).

DOK4_HUMAN
θ value	2.52405e-10 (rank : 10)	NC score	0.571915 (rank : 10)
Query Neighborhood Hits	46	Target Neighborhood Hits	28	Shared Neighborhood Hits	17
SwissProt Accessions	Q8TEW6, O75209, Q9BTP2, Q9NVV3	Gene names	DOK4
Domain Architecture	No domain graphic available
Description	Docking protein 4 (Downstream of tyrosine kinase 4).

DOK4_MOUSE
θ value	2.52405e-10 (rank : 11)	NC score	0.570716 (rank : 11)
Query Neighborhood Hits	46	Target Neighborhood Hits	30	Shared Neighborhood Hits	17
SwissProt Accessions	Q99KE3, Q3U0X3	Gene names	Dok4
Domain Architecture	No domain graphic available
Description	Docking protein 4 (Downstream of tyrosine kinase 4).

FRS3_MOUSE
θ value	2.79066e-09 (rank : 12)	NC score	0.503670 (rank : 13)
Query Neighborhood Hits	46	Target Neighborhood Hits	168	Shared Neighborhood Hits	17
SwissProt Accessions	Q91WJ0	Gene names	Frs3, Frs2b
Domain Architecture	No domain graphic available
Description	Fibroblast growth factor receptor substrate 3 (FGFR substrate 3) (FRS2-beta).

FRS3_HUMAN
θ value	2.36244e-08 (rank : 13)	NC score	0.508692 (rank : 12)
Query Neighborhood Hits	46	Target Neighborhood Hits	76	Shared Neighborhood Hits	17
SwissProt Accessions	O43559, Q5T3D5	Gene names	FRS3
Domain Architecture	No domain graphic available
Description	Fibroblast growth factor receptor substrate 3 (FGFR substrate 3) (Suc1-associated neurotrophic factor target 2) (SNT-2) (FGFR signaling adaptor SNT2).

FRS2_MOUSE
θ value	5.81887e-07 (rank : 14)	NC score	0.482808 (rank : 14)
Query Neighborhood Hits	46	Target Neighborhood Hits	41	Shared Neighborhood Hits	18
SwissProt Accessions	Q8C180	Gene names	Frs2, Frs2a
Domain Architecture	No domain graphic available
Description	Fibroblast growth factor receptor substrate 2 (FGFR substrate 2) (Suc1-associated neurotrophic factor target 1) (SNT-1) (FGFR signaling adaptor SNT) (FRS2 alpha).

FRS2_HUMAN
θ value	1.69304e-06 (rank : 15)	NC score	0.480450 (rank : 15)
Query Neighborhood Hits	46	Target Neighborhood Hits	40	Shared Neighborhood Hits	17
SwissProt Accessions	Q8WU20, O43558, Q7LDQ6	Gene names	FRS2
Domain Architecture	No domain graphic available
Description	Fibroblast growth factor receptor substrate 2 (FGFR substrate 2) (Suc1-associated neurotrophic factor target 1) (SNT-1) (FGFR signaling adaptor SNT).

IRS2_MOUSE
θ value	0.0431538 (rank : 16)	NC score	0.080123 (rank : 19)
Query Neighborhood Hits	46	Target Neighborhood Hits	248	Shared Neighborhood Hits	13
SwissProt Accessions	P81122	Gene names	Irs2
Domain Architecture	No domain graphic available
Description	Insulin receptor substrate 2 (IRS-2) (4PS).

ETV5_MOUSE
θ value	0.21417 (rank : 17)	NC score	0.020819 (rank : 31)
Query Neighborhood Hits	46	Target Neighborhood Hits	328	Shared Neighborhood Hits	5
SwissProt Accessions	Q9CXC9, Q3TG49, Q8C0F3, Q9JHB1	Gene names	Etv5
Domain Architecture	No domain graphic available
Description	ETS translocation variant 5.

HCLS1_HUMAN
θ value	0.365318 (rank : 18)	NC score	0.023712 (rank : 28)
Query Neighborhood Hits	46	Target Neighborhood Hits	358	Shared Neighborhood Hits	6
SwissProt Accessions	P14317	Gene names	HCLS1, HS1
Domain Architecture
Description	Hematopoietic lineage cell-specific protein (Hematopoietic cell- specific LYN substrate 1) (LckBP1) (p75).

P73_HUMAN
θ value	0.365318 (rank : 19)	NC score	0.032765 (rank : 25)
Query Neighborhood Hits	46	Target Neighborhood Hits	71	Shared Neighborhood Hits	2
SwissProt Accessions	O15350, O15351, Q5TBV5, Q5TBV6, Q8NHW9, Q8TDY5, Q8TDY6, Q9NTK8	Gene names	TP73, P73
Domain Architecture
Description	Tumor protein p73 (p53-like transcription factor) (p53-related protein).

PDXL2_MOUSE
θ value	0.365318 (rank : 20)	NC score	0.040170 (rank : 22)
Query Neighborhood Hits	46	Target Neighborhood Hits	213	Shared Neighborhood Hits	3
SwissProt Accessions	Q8CAE9, Q8CFW3	Gene names	Podxl2
Domain Architecture	No domain graphic available
Description	Podocalyxin-like protein 2 precursor (Endoglycan).

TXND2_HUMAN
θ value	0.365318 (rank : 21)	NC score	0.021634 (rank : 30)
Query Neighborhood Hits	46	Target Neighborhood Hits	793	Shared Neighborhood Hits	8
SwissProt Accessions	Q86VQ3, Q8N7U4, Q96RX3, Q9H0L8	Gene names	TXNDC2, SPTRX, SPTRX1
Domain Architecture	No domain graphic available
Description	Thioredoxin domain-containing protein 2 (Spermatid-specific thioredoxin-1) (Sptrx-1).

DOK7_MOUSE
θ value	0.813845 (rank : 22)	NC score	0.168546 (rank : 17)
Query Neighborhood Hits	46	Target Neighborhood Hits	169	Shared Neighborhood Hits	20
SwissProt Accessions	Q18PE0, Q3TCZ6, Q5FW70, Q8C8U7	Gene names	Dok7
Domain Architecture	No domain graphic available
Description	Protein Dok-7 (Downstream of tyrosine kinase 7).

RTKN_HUMAN
θ value	0.813845 (rank : 23)	NC score	0.033925 (rank : 23)
Query Neighborhood Hits	46	Target Neighborhood Hits	97	Shared Neighborhood Hits	2
SwissProt Accessions	Q9BST9, Q8WVN1, Q96PT6, Q9HB05	Gene names	RTKN
Domain Architecture	No domain graphic available
Description	Rhotekin.

F120C_MOUSE
θ value	1.38821 (rank : 24)	NC score	0.023702 (rank : 29)
Query Neighborhood Hits	46	Target Neighborhood Hits	98	Shared Neighborhood Hits	3
SwissProt Accessions	Q8C3F2	Gene names	Fam120c, ORF34
Domain Architecture	No domain graphic available
Description	UPF0318 protein FAM120C.

GAB2_MOUSE
θ value	2.36792 (rank : 25)	NC score	0.033238 (rank : 24)
Query Neighborhood Hits	46	Target Neighborhood Hits	220	Shared Neighborhood Hits	7
SwissProt Accessions	Q9Z1S8, Q9R1X3	Gene names	Gab2
Domain Architecture
Description	GRB2-associated-binding protein 2 (GRB2-associated binder 2) (PH domain-containing adaptor molecule p97).

ANR11_HUMAN
θ value	3.0926 (rank : 26)	NC score	0.007845 (rank : 41)
Query Neighborhood Hits	46	Target Neighborhood Hits	1289	Shared Neighborhood Hits	10
SwissProt Accessions	Q6UB99, Q6NTG1, Q6QMF8	Gene names	ANKRD11, ANCO1
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 11 (Ankyrin repeat-containing cofactor 1).

DC1L2_MOUSE
θ value	3.0926 (rank : 27)	NC score	0.016092 (rank : 33)
Query Neighborhood Hits	46	Target Neighborhood Hits	173	Shared Neighborhood Hits	3
SwissProt Accessions	Q6PDL0	Gene names	Dync1li2, Dncli2, Dnclic2
Domain Architecture	No domain graphic available
Description	Cytoplasmic dynein 1 light intermediate chain 2 (Dynein light intermediate chain 2, cytosolic).

MLL3_HUMAN
θ value	3.0926 (rank : 28)	NC score	0.010550 (rank : 38)
Query Neighborhood Hits	46	Target Neighborhood Hits	1644	Shared Neighborhood Hits	11
SwissProt Accessions	Q8NEZ4, Q8NC02, Q8NDF6, Q9H9P4, Q9NR13, Q9P222, Q9UDR7	Gene names	MLL3, HALR, KIAA1506
Domain Architecture
Description	Myeloid/lymphoid or mixed-lineage leukemia protein 3 homolog (EC 2.1.1.43) (Histone-lysine N-methyltransferase, H3 lysine-4 specific MLL3) (Homologous to ALR protein).

K0460_HUMAN
θ value	4.03905 (rank : 29)	NC score	0.023877 (rank : 27)
Query Neighborhood Hits	46	Target Neighborhood Hits	357	Shared Neighborhood Hits	9
SwissProt Accessions	Q5VT52, O75048, Q5VT53, Q6MZL4, Q86XD2	Gene names	KIAA0460
Domain Architecture	No domain graphic available
Description	Protein KIAA0460.

PELP1_MOUSE
θ value	4.03905 (rank : 30)	NC score	0.051534 (rank : 21)
Query Neighborhood Hits	46	Target Neighborhood Hits	709	Shared Neighborhood Hits	14
SwissProt Accessions	Q9DBD5, Q5F2E2, Q6PEM0, Q91YM9	Gene names	Pelp1, Mnar
Domain Architecture	No domain graphic available
Description	Proline-, glutamic acid- and leucine-rich protein 1 (Modulator of nongenomic activity of estrogen receptor).

YETS2_HUMAN
θ value	4.03905 (rank : 31)	NC score	0.016048 (rank : 34)
Query Neighborhood Hits	46	Target Neighborhood Hits	212	Shared Neighborhood Hits	2
SwissProt Accessions	Q9ULM3, Q641P6, Q9NW96	Gene names	YEATS2, KIAA1197
Domain Architecture	No domain graphic available
Description	YEATS domain-containing protein 2.

ZN467_MOUSE
θ value	4.03905 (rank : 32)	NC score	-0.001534 (rank : 47)
Query Neighborhood Hits	46	Target Neighborhood Hits	794	Shared Neighborhood Hits	2
SwissProt Accessions	Q8JZL0, Q9JJ98	Gene names	Znf467, Ezi, Zfp467
Domain Architecture	No domain graphic available
Description	Zinc finger protein 467 (Endothelial cell-derived zinc finger protein) (EZI).

CHST8_HUMAN
θ value	5.27518 (rank : 33)	NC score	0.013371 (rank : 35)
Query Neighborhood Hits	46	Target Neighborhood Hits	20	Shared Neighborhood Hits	3
SwissProt Accessions	Q9H2A9, Q9H3N2	Gene names	CHST8
Domain Architecture	No domain graphic available
Description	Carbohydrate sulfotransferase 8 (EC 2.8.2.-) (N-acetylgalactosamine-4- O-sulfotransferase 1) (GalNAc-4-O-sulfotransferase 1) (GalNAc-4-ST1) (GalNAc4ST-1).

DUET_HUMAN
θ value	5.27518 (rank : 34)	NC score	-0.000640 (rank : 46)
Query Neighborhood Hits	46	Target Neighborhood Hits	1220	Shared Neighborhood Hits	4
SwissProt Accessions	Q9Y2A5, Q8TBQ5, Q9NSZ4	Gene names	DUET, TRAD
Domain Architecture
Description	Serine/threonine-protein kinase Duet (EC 2.7.11.1) (Serine/threonine kinase with Dbl- and pleckstrin homology domain).

EFS_MOUSE
θ value	6.88961 (rank : 35)	NC score	0.011308 (rank : 37)
Query Neighborhood Hits	46	Target Neighborhood Hits	389	Shared Neighborhood Hits	8
SwissProt Accessions	Q64355	Gene names	Efs, Sin
Domain Architecture
Description	Embryonal Fyn-associated substrate (SRC-interacting protein) (Signal- integrating protein).

FA50A_HUMAN
θ value	6.88961 (rank : 36)	NC score	0.009766 (rank : 39)
Query Neighborhood Hits	46	Target Neighborhood Hits	264	Shared Neighborhood Hits	5
SwissProt Accessions	Q14320, Q5HY37	Gene names	FAM50A, DXS9928E, HXC26, XAP5
Domain Architecture
Description	Protein FAM50A (Protein XAP-5) (Protein HXC-26).

GAB2_HUMAN
θ value	6.88961 (rank : 37)	NC score	0.030763 (rank : 26)
Query Neighborhood Hits	46	Target Neighborhood Hits	188	Shared Neighborhood Hits	8
SwissProt Accessions	Q9UQC2, O60317	Gene names	GAB2, KIAA0571
Domain Architecture
Description	GRB2-associated-binding protein 2 (GRB2-associated binder 2) (pp100).

K0460_MOUSE
θ value	6.88961 (rank : 38)	NC score	0.019791 (rank : 32)
Query Neighborhood Hits	46	Target Neighborhood Hits	374	Shared Neighborhood Hits	6
SwissProt Accessions	Q6NXI6, Q3U3L8, Q6ZQA7	Gene names	Kiaa0460
Domain Architecture	No domain graphic available
Description	Protein KIAA0460.

SIG10_HUMAN
θ value	6.88961 (rank : 39)	NC score	0.004363 (rank : 43)
Query Neighborhood Hits	46	Target Neighborhood Hits	363	Shared Neighborhood Hits	2
SwissProt Accessions	Q96LC7, Q6UXI8, Q96G54, Q96LC8	Gene names	SIGLEC10, SLG2
Domain Architecture
Description	Sialic acid-binding Ig-like lectin 10 precursor (Siglec-10) (Siglec- like protein 2).

TCGAP_HUMAN
θ value	6.88961 (rank : 40)	NC score	0.012792 (rank : 36)
Query Neighborhood Hits	46	Target Neighborhood Hits	872	Shared Neighborhood Hits	12
SwissProt Accessions	O14559, O14552, O14560, Q6ZSP6, Q96CP3, Q9NT23	Gene names	SNX26, TCGAP
Domain Architecture
Description	TC10/CDC42 GTPase-activating protein (Sorting nexin-26).

AATK_HUMAN
θ value	8.99809 (rank : 41)	NC score	-0.000248 (rank : 45)
Query Neighborhood Hits	46	Target Neighborhood Hits	1243	Shared Neighborhood Hits	9
SwissProt Accessions	Q6ZMQ8, O75136, Q6ZN31, Q86X28	Gene names	AATK, KIAA0641
Domain Architecture	No domain graphic available
Description	Apoptosis-associated tyrosine-protein kinase (EC 2.7.10.2) (AATYK) (Brain apoptosis-associated tyrosine kinase) (CDK5-binding protein) (p35-binding protein) (p35BP).

DKK2_MOUSE
θ value	8.99809 (rank : 42)	NC score	0.009274 (rank : 40)
Query Neighborhood Hits	46	Target Neighborhood Hits	34	Shared Neighborhood Hits	2
SwissProt Accessions	Q9QYZ8	Gene names	Dkk2
Domain Architecture
Description	Dickkopf-related protein 2 precursor (Dkk-2) (Dickkopf-2) (mDkk-2).

DOK7_HUMAN
θ value	8.99809 (rank : 43)	NC score	0.179780 (rank : 16)
Query Neighborhood Hits	46	Target Neighborhood Hits	51	Shared Neighborhood Hits	17
SwissProt Accessions	Q18PE1, Q6P6A6, Q86XG5, Q8N2J3, Q8NBC1	Gene names	DOK7, C4orf25
Domain Architecture	No domain graphic available
Description	Protein Dok-7 (Downstream of tyrosine kinase 7).

MRCKB_MOUSE
θ value	8.99809 (rank : 44)	NC score	-0.002480 (rank : 48)
Query Neighborhood Hits	46	Target Neighborhood Hits	2180	Shared Neighborhood Hits	6
SwissProt Accessions	Q7TT50, Q69ZR5, Q80W33	Gene names	Cdc42bpb, Kiaa1124
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MRCK beta (EC 2.7.11.1) (CDC42-binding protein kinase beta) (Myotonic dystrophy kinase-related CDC42-binding kinase beta) (Myotonic dystrophy protein kinase-like beta) (MRCK beta) (DMPK-like beta).

OSBP2_MOUSE
θ value	8.99809 (rank : 45)	NC score	0.006115 (rank : 42)
Query Neighborhood Hits	46	Target Neighborhood Hits	150	Shared Neighborhood Hits	4
SwissProt Accessions	Q5QNQ6, Q8CF21	Gene names	Osbp2
Domain Architecture	No domain graphic available
Description	Oxysterol-binding protein 2.

TEX14_MOUSE
θ value	8.99809 (rank : 46)	NC score	0.000939 (rank : 44)
Query Neighborhood Hits	46	Target Neighborhood Hits	1333	Shared Neighborhood Hits	5
SwissProt Accessions	Q7M6U3, Q3UT36, Q5NC10, Q5NC11, Q8CGK1, Q8CGK2, Q99MV8	Gene names	Tex14
Domain Architecture	No domain graphic available
Description	Testis-expressed protein 14 (Testis-expressed sequence 14).

IRS1_HUMAN
θ value	θ > 10 (rank : 47)	NC score	0.076541 (rank : 20)
Query Neighborhood Hits	46	Target Neighborhood Hits	109	Shared Neighborhood Hits	11
SwissProt Accessions	P35568	Gene names	IRS1
Domain Architecture
Description	Insulin receptor substrate 1 (IRS-1).

IRS1_MOUSE
θ value	θ > 10 (rank : 48)	NC score	0.094267 (rank : 18)
Query Neighborhood Hits	46	Target Neighborhood Hits	112	Shared Neighborhood Hits	12
SwissProt Accessions	P35569	Gene names	Irs1, Irs-1
Domain Architecture
Description	Insulin receptor substrate 1 (IRS-1).

Hits sorted by NC score

DOK2_HUMAN
NC score	0.999962 (rank : 1)	θ value	0 (rank : 1)
Query Neighborhood Hits	46	Target Neighborhood Hits	46	Shared Neighborhood Hits	46
SwissProt Accessions	O60496	Gene names	DOK2
Domain Architecture
Description	Docking protein 2 (Downstream of tyrosine kinase 2) (p56(dok-2)).

DOK2_MOUSE
NC score	0.928016 (rank : 2)	θ value	5.36813e-170 (rank : 2)
Query Neighborhood Hits	46	Target Neighborhood Hits	244	Shared Neighborhood Hits	22
SwissProt Accessions	O70469, O70272, Q99KL1	Gene names	Dok2, Frip
Domain Architecture
Description	Docking protein 2 (Downstream of tyrosine kinase 2) (p56(dok-2)) (Dok- related protein) (Dok-R) (IL-four receptor-interacting protein) (FRIP).

DOK3_MOUSE
NC score	0.899447 (rank : 3)	θ value	4.55743e-44 (rank : 6)
Query Neighborhood Hits	46	Target Neighborhood Hits	25	Shared Neighborhood Hits	19
SwissProt Accessions	Q9QZK7	Gene names	Dok3, Dokl
Domain Architecture	No domain graphic available
Description	Docking protein 3 (Downstream of tyrosine kinase 3) (P62(dok)-like protein) (DOK-L).

DOK3_HUMAN
NC score	0.890790 (rank : 4)	θ value	5.20228e-48 (rank : 3)
Query Neighborhood Hits	46	Target Neighborhood Hits	60	Shared Neighborhood Hits	19
SwissProt Accessions	Q7L591, Q8N864, Q9BQB3, Q9H666	Gene names	DOK3
Domain Architecture	No domain graphic available
Description	Docking protein 3 (Downstream of tyrosine kinase 3).

DOK1_MOUSE
NC score	0.889051 (rank : 5)	θ value	4.122e-45 (rank : 5)
Query Neighborhood Hits	46	Target Neighborhood Hits	82	Shared Neighborhood Hits	18
SwissProt Accessions	P97465, Q9R213	Gene names	Dok1, Dok
Domain Architecture
Description	Docking protein 1 (Downstream of tyrosine kinase 1) (p62(dok)).

DOK1_HUMAN
NC score	0.883370 (rank : 6)	θ value	2.58187e-47 (rank : 4)
Query Neighborhood Hits	46	Target Neighborhood Hits	85	Shared Neighborhood Hits	18
SwissProt Accessions	Q99704, O43204, Q9UHG6	Gene names	DOK1
Domain Architecture
Description	Docking protein 1 (Downstream of tyrosine kinase 1) (p62(dok)) (pp62).

DOK6_HUMAN
NC score	0.591871 (rank : 7)	θ value	9.26847e-13 (rank : 7)
Query Neighborhood Hits	46	Target Neighborhood Hits	25	Shared Neighborhood Hits	18
SwissProt Accessions	Q6PKX4, Q4V9S3, Q8WUZ8, Q96HI2, Q96LU2	Gene names	DOK6, DOK5L
Domain Architecture	No domain graphic available
Description	Docking protein 6 (Downstream of tyrosine kinase 6).

DOK5_MOUSE
NC score	0.585577 (rank : 8)	θ value	1.133e-10 (rank : 9)
Query Neighborhood Hits	46	Target Neighborhood Hits	27	Shared Neighborhood Hits	18
SwissProt Accessions	Q91ZM9, Q8BRI3, Q9CSM6	Gene names	Dok5
Domain Architecture
Description	Docking protein 5 (Downstream of tyrosine kinase 5) (Protein dok-5).

DOK5_HUMAN
NC score	0.584501 (rank : 9)	θ value	1.133e-10 (rank : 8)
Query Neighborhood Hits	46	Target Neighborhood Hits	28	Shared Neighborhood Hits	18
SwissProt Accessions	Q9P104, Q5T7Y0, Q5TE53, Q8TEW7, Q96H13, Q9BZ24, Q9NQF4, Q9Y411	Gene names	DOK5, C20orf180
Domain Architecture
Description	Docking protein 5 (Downstream of tyrosine kinase 5) (IRS6) (Protein dok-5).

DOK4_HUMAN
NC score	0.571915 (rank : 10)	θ value	2.52405e-10 (rank : 10)
Query Neighborhood Hits	46	Target Neighborhood Hits	28	Shared Neighborhood Hits	17
SwissProt Accessions	Q8TEW6, O75209, Q9BTP2, Q9NVV3	Gene names	DOK4
Domain Architecture	No domain graphic available
Description	Docking protein 4 (Downstream of tyrosine kinase 4).

DOK4_MOUSE
NC score	0.570716 (rank : 11)	θ value	2.52405e-10 (rank : 11)
Query Neighborhood Hits	46	Target Neighborhood Hits	30	Shared Neighborhood Hits	17
SwissProt Accessions	Q99KE3, Q3U0X3	Gene names	Dok4
Domain Architecture	No domain graphic available
Description	Docking protein 4 (Downstream of tyrosine kinase 4).

FRS3_HUMAN
NC score	0.508692 (rank : 12)	θ value	2.36244e-08 (rank : 13)
Query Neighborhood Hits	46	Target Neighborhood Hits	76	Shared Neighborhood Hits	17
SwissProt Accessions	O43559, Q5T3D5	Gene names	FRS3
Domain Architecture	No domain graphic available
Description	Fibroblast growth factor receptor substrate 3 (FGFR substrate 3) (Suc1-associated neurotrophic factor target 2) (SNT-2) (FGFR signaling adaptor SNT2).

FRS3_MOUSE
NC score	0.503670 (rank : 13)	θ value	2.79066e-09 (rank : 12)
Query Neighborhood Hits	46	Target Neighborhood Hits	168	Shared Neighborhood Hits	17
SwissProt Accessions	Q91WJ0	Gene names	Frs3, Frs2b
Domain Architecture	No domain graphic available
Description	Fibroblast growth factor receptor substrate 3 (FGFR substrate 3) (FRS2-beta).

FRS2_MOUSE
NC score	0.482808 (rank : 14)	θ value	5.81887e-07 (rank : 14)
Query Neighborhood Hits	46	Target Neighborhood Hits	41	Shared Neighborhood Hits	18
SwissProt Accessions	Q8C180	Gene names	Frs2, Frs2a
Domain Architecture	No domain graphic available
Description	Fibroblast growth factor receptor substrate 2 (FGFR substrate 2) (Suc1-associated neurotrophic factor target 1) (SNT-1) (FGFR signaling adaptor SNT) (FRS2 alpha).

FRS2_HUMAN
NC score	0.480450 (rank : 15)	θ value	1.69304e-06 (rank : 15)
Query Neighborhood Hits	46	Target Neighborhood Hits	40	Shared Neighborhood Hits	17
SwissProt Accessions	Q8WU20, O43558, Q7LDQ6	Gene names	FRS2
Domain Architecture	No domain graphic available
Description	Fibroblast growth factor receptor substrate 2 (FGFR substrate 2) (Suc1-associated neurotrophic factor target 1) (SNT-1) (FGFR signaling adaptor SNT).

DOK7_HUMAN
NC score	0.179780 (rank : 16)	θ value	8.99809 (rank : 43)
Query Neighborhood Hits	46	Target Neighborhood Hits	51	Shared Neighborhood Hits	17
SwissProt Accessions	Q18PE1, Q6P6A6, Q86XG5, Q8N2J3, Q8NBC1	Gene names	DOK7, C4orf25
Domain Architecture	No domain graphic available
Description	Protein Dok-7 (Downstream of tyrosine kinase 7).

DOK7_MOUSE
NC score	0.168546 (rank : 17)	θ value	0.813845 (rank : 22)
Query Neighborhood Hits	46	Target Neighborhood Hits	169	Shared Neighborhood Hits	20
SwissProt Accessions	Q18PE0, Q3TCZ6, Q5FW70, Q8C8U7	Gene names	Dok7
Domain Architecture	No domain graphic available
Description	Protein Dok-7 (Downstream of tyrosine kinase 7).

IRS1_MOUSE
NC score	0.094267 (rank : 18)	θ value	θ > 10 (rank : 48)
Query Neighborhood Hits	46	Target Neighborhood Hits	112	Shared Neighborhood Hits	12
SwissProt Accessions	P35569	Gene names	Irs1, Irs-1
Domain Architecture
Description	Insulin receptor substrate 1 (IRS-1).

IRS2_MOUSE
NC score	0.080123 (rank : 19)	θ value	0.0431538 (rank : 16)
Query Neighborhood Hits	46	Target Neighborhood Hits	248	Shared Neighborhood Hits	13
SwissProt Accessions	P81122	Gene names	Irs2
Domain Architecture	No domain graphic available
Description	Insulin receptor substrate 2 (IRS-2) (4PS).

IRS1_HUMAN
NC score	0.076541 (rank : 20)	θ value	θ > 10 (rank : 47)
Query Neighborhood Hits	46	Target Neighborhood Hits	109	Shared Neighborhood Hits	11
SwissProt Accessions	P35568	Gene names	IRS1
Domain Architecture
Description	Insulin receptor substrate 1 (IRS-1).

PELP1_MOUSE
NC score	0.051534 (rank : 21)	θ value	4.03905 (rank : 30)
Query Neighborhood Hits	46	Target Neighborhood Hits	709	Shared Neighborhood Hits	14
SwissProt Accessions	Q9DBD5, Q5F2E2, Q6PEM0, Q91YM9	Gene names	Pelp1, Mnar
Domain Architecture	No domain graphic available
Description	Proline-, glutamic acid- and leucine-rich protein 1 (Modulator of nongenomic activity of estrogen receptor).

PDXL2_MOUSE
NC score	0.040170 (rank : 22)	θ value	0.365318 (rank : 20)
Query Neighborhood Hits	46	Target Neighborhood Hits	213	Shared Neighborhood Hits	3
SwissProt Accessions	Q8CAE9, Q8CFW3	Gene names	Podxl2
Domain Architecture	No domain graphic available
Description	Podocalyxin-like protein 2 precursor (Endoglycan).

RTKN_HUMAN
NC score	0.033925 (rank : 23)	θ value	0.813845 (rank : 23)
Query Neighborhood Hits	46	Target Neighborhood Hits	97	Shared Neighborhood Hits	2
SwissProt Accessions	Q9BST9, Q8WVN1, Q96PT6, Q9HB05	Gene names	RTKN
Domain Architecture	No domain graphic available
Description	Rhotekin.

GAB2_MOUSE
NC score	0.033238 (rank : 24)	θ value	2.36792 (rank : 25)
Query Neighborhood Hits	46	Target Neighborhood Hits	220	Shared Neighborhood Hits	7
SwissProt Accessions	Q9Z1S8, Q9R1X3	Gene names	Gab2
Domain Architecture
Description	GRB2-associated-binding protein 2 (GRB2-associated binder 2) (PH domain-containing adaptor molecule p97).

P73_HUMAN
NC score	0.032765 (rank : 25)	θ value	0.365318 (rank : 19)
Query Neighborhood Hits	46	Target Neighborhood Hits	71	Shared Neighborhood Hits	2
SwissProt Accessions	O15350, O15351, Q5TBV5, Q5TBV6, Q8NHW9, Q8TDY5, Q8TDY6, Q9NTK8	Gene names	TP73, P73
Domain Architecture
Description	Tumor protein p73 (p53-like transcription factor) (p53-related protein).

GAB2_HUMAN
NC score	0.030763 (rank : 26)	θ value	6.88961 (rank : 37)
Query Neighborhood Hits	46	Target Neighborhood Hits	188	Shared Neighborhood Hits	8
SwissProt Accessions	Q9UQC2, O60317	Gene names	GAB2, KIAA0571
Domain Architecture
Description	GRB2-associated-binding protein 2 (GRB2-associated binder 2) (pp100).

K0460_HUMAN
NC score	0.023877 (rank : 27)	θ value	4.03905 (rank : 29)
Query Neighborhood Hits	46	Target Neighborhood Hits	357	Shared Neighborhood Hits	9
SwissProt Accessions	Q5VT52, O75048, Q5VT53, Q6MZL4, Q86XD2	Gene names	KIAA0460
Domain Architecture	No domain graphic available
Description	Protein KIAA0460.

HCLS1_HUMAN
NC score	0.023712 (rank : 28)	θ value	0.365318 (rank : 18)
Query Neighborhood Hits	46	Target Neighborhood Hits	358	Shared Neighborhood Hits	6
SwissProt Accessions	P14317	Gene names	HCLS1, HS1
Domain Architecture
Description	Hematopoietic lineage cell-specific protein (Hematopoietic cell- specific LYN substrate 1) (LckBP1) (p75).

F120C_MOUSE
NC score	0.023702 (rank : 29)	θ value	1.38821 (rank : 24)
Query Neighborhood Hits	46	Target Neighborhood Hits	98	Shared Neighborhood Hits	3
SwissProt Accessions	Q8C3F2	Gene names	Fam120c, ORF34
Domain Architecture	No domain graphic available
Description	UPF0318 protein FAM120C.

TXND2_HUMAN
NC score	0.021634 (rank : 30)	θ value	0.365318 (rank : 21)
Query Neighborhood Hits	46	Target Neighborhood Hits	793	Shared Neighborhood Hits	8
SwissProt Accessions	Q86VQ3, Q8N7U4, Q96RX3, Q9H0L8	Gene names	TXNDC2, SPTRX, SPTRX1
Domain Architecture	No domain graphic available
Description	Thioredoxin domain-containing protein 2 (Spermatid-specific thioredoxin-1) (Sptrx-1).

ETV5_MOUSE
NC score	0.020819 (rank : 31)	θ value	0.21417 (rank : 17)
Query Neighborhood Hits	46	Target Neighborhood Hits	328	Shared Neighborhood Hits	5
SwissProt Accessions	Q9CXC9, Q3TG49, Q8C0F3, Q9JHB1	Gene names	Etv5
Domain Architecture	No domain graphic available
Description	ETS translocation variant 5.

K0460_MOUSE
NC score	0.019791 (rank : 32)	θ value	6.88961 (rank : 38)
Query Neighborhood Hits	46	Target Neighborhood Hits	374	Shared Neighborhood Hits	6
SwissProt Accessions	Q6NXI6, Q3U3L8, Q6ZQA7	Gene names	Kiaa0460
Domain Architecture	No domain graphic available
Description	Protein KIAA0460.

DC1L2_MOUSE
NC score	0.016092 (rank : 33)	θ value	3.0926 (rank : 27)
Query Neighborhood Hits	46	Target Neighborhood Hits	173	Shared Neighborhood Hits	3
SwissProt Accessions	Q6PDL0	Gene names	Dync1li2, Dncli2, Dnclic2
Domain Architecture	No domain graphic available
Description	Cytoplasmic dynein 1 light intermediate chain 2 (Dynein light intermediate chain 2, cytosolic).

YETS2_HUMAN
NC score	0.016048 (rank : 34)	θ value	4.03905 (rank : 31)
Query Neighborhood Hits	46	Target Neighborhood Hits	212	Shared Neighborhood Hits	2
SwissProt Accessions	Q9ULM3, Q641P6, Q9NW96	Gene names	YEATS2, KIAA1197
Domain Architecture	No domain graphic available
Description	YEATS domain-containing protein 2.

CHST8_HUMAN
NC score	0.013371 (rank : 35)	θ value	5.27518 (rank : 33)
Query Neighborhood Hits	46	Target Neighborhood Hits	20	Shared Neighborhood Hits	3
SwissProt Accessions	Q9H2A9, Q9H3N2	Gene names	CHST8
Domain Architecture	No domain graphic available
Description	Carbohydrate sulfotransferase 8 (EC 2.8.2.-) (N-acetylgalactosamine-4- O-sulfotransferase 1) (GalNAc-4-O-sulfotransferase 1) (GalNAc-4-ST1) (GalNAc4ST-1).

TCGAP_HUMAN
NC score	0.012792 (rank : 36)	θ value	6.88961 (rank : 40)
Query Neighborhood Hits	46	Target Neighborhood Hits	872	Shared Neighborhood Hits	12
SwissProt Accessions	O14559, O14552, O14560, Q6ZSP6, Q96CP3, Q9NT23	Gene names	SNX26, TCGAP
Domain Architecture
Description	TC10/CDC42 GTPase-activating protein (Sorting nexin-26).

EFS_MOUSE
NC score	0.011308 (rank : 37)	θ value	6.88961 (rank : 35)
Query Neighborhood Hits	46	Target Neighborhood Hits	389	Shared Neighborhood Hits	8
SwissProt Accessions	Q64355	Gene names	Efs, Sin
Domain Architecture
Description	Embryonal Fyn-associated substrate (SRC-interacting protein) (Signal- integrating protein).

MLL3_HUMAN
NC score	0.010550 (rank : 38)	θ value	3.0926 (rank : 28)
Query Neighborhood Hits	46	Target Neighborhood Hits	1644	Shared Neighborhood Hits	11
SwissProt Accessions	Q8NEZ4, Q8NC02, Q8NDF6, Q9H9P4, Q9NR13, Q9P222, Q9UDR7	Gene names	MLL3, HALR, KIAA1506
Domain Architecture
Description	Myeloid/lymphoid or mixed-lineage leukemia protein 3 homolog (EC 2.1.1.43) (Histone-lysine N-methyltransferase, H3 lysine-4 specific MLL3) (Homologous to ALR protein).

FA50A_HUMAN
NC score	0.009766 (rank : 39)	θ value	6.88961 (rank : 36)
Query Neighborhood Hits	46	Target Neighborhood Hits	264	Shared Neighborhood Hits	5
SwissProt Accessions	Q14320, Q5HY37	Gene names	FAM50A, DXS9928E, HXC26, XAP5
Domain Architecture
Description	Protein FAM50A (Protein XAP-5) (Protein HXC-26).

DKK2_MOUSE
NC score	0.009274 (rank : 40)	θ value	8.99809 (rank : 42)
Query Neighborhood Hits	46	Target Neighborhood Hits	34	Shared Neighborhood Hits	2
SwissProt Accessions	Q9QYZ8	Gene names	Dkk2
Domain Architecture
Description	Dickkopf-related protein 2 precursor (Dkk-2) (Dickkopf-2) (mDkk-2).

ANR11_HUMAN
NC score	0.007845 (rank : 41)	θ value	3.0926 (rank : 26)
Query Neighborhood Hits	46	Target Neighborhood Hits	1289	Shared Neighborhood Hits	10
SwissProt Accessions	Q6UB99, Q6NTG1, Q6QMF8	Gene names	ANKRD11, ANCO1
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 11 (Ankyrin repeat-containing cofactor 1).

OSBP2_MOUSE
NC score	0.006115 (rank : 42)	θ value	8.99809 (rank : 45)
Query Neighborhood Hits	46	Target Neighborhood Hits	150	Shared Neighborhood Hits	4
SwissProt Accessions	Q5QNQ6, Q8CF21	Gene names	Osbp2
Domain Architecture	No domain graphic available
Description	Oxysterol-binding protein 2.

SIG10_HUMAN
NC score	0.004363 (rank : 43)	θ value	6.88961 (rank : 39)
Query Neighborhood Hits	46	Target Neighborhood Hits	363	Shared Neighborhood Hits	2
SwissProt Accessions	Q96LC7, Q6UXI8, Q96G54, Q96LC8	Gene names	SIGLEC10, SLG2
Domain Architecture
Description	Sialic acid-binding Ig-like lectin 10 precursor (Siglec-10) (Siglec- like protein 2).

TEX14_MOUSE
NC score	0.000939 (rank : 44)	θ value	8.99809 (rank : 46)
Query Neighborhood Hits	46	Target Neighborhood Hits	1333	Shared Neighborhood Hits	5
SwissProt Accessions	Q7M6U3, Q3UT36, Q5NC10, Q5NC11, Q8CGK1, Q8CGK2, Q99MV8	Gene names	Tex14
Domain Architecture	No domain graphic available
Description	Testis-expressed protein 14 (Testis-expressed sequence 14).

AATK_HUMAN
NC score	-0.000248 (rank : 45)	θ value	8.99809 (rank : 41)
Query Neighborhood Hits	46	Target Neighborhood Hits	1243	Shared Neighborhood Hits	9
SwissProt Accessions	Q6ZMQ8, O75136, Q6ZN31, Q86X28	Gene names	AATK, KIAA0641
Domain Architecture	No domain graphic available
Description	Apoptosis-associated tyrosine-protein kinase (EC 2.7.10.2) (AATYK) (Brain apoptosis-associated tyrosine kinase) (CDK5-binding protein) (p35-binding protein) (p35BP).

DUET_HUMAN
NC score	-0.000640 (rank : 46)	θ value	5.27518 (rank : 34)
Query Neighborhood Hits	46	Target Neighborhood Hits	1220	Shared Neighborhood Hits	4
SwissProt Accessions	Q9Y2A5, Q8TBQ5, Q9NSZ4	Gene names	DUET, TRAD
Domain Architecture
Description	Serine/threonine-protein kinase Duet (EC 2.7.11.1) (Serine/threonine kinase with Dbl- and pleckstrin homology domain).

ZN467_MOUSE
NC score	-0.001534 (rank : 47)	θ value	4.03905 (rank : 32)
Query Neighborhood Hits	46	Target Neighborhood Hits	794	Shared Neighborhood Hits	2
SwissProt Accessions	Q8JZL0, Q9JJ98	Gene names	Znf467, Ezi, Zfp467
Domain Architecture	No domain graphic available
Description	Zinc finger protein 467 (Endothelial cell-derived zinc finger protein) (EZI).

MRCKB_MOUSE
NC score	-0.002480 (rank : 48)	θ value	8.99809 (rank : 44)
Query Neighborhood Hits	46	Target Neighborhood Hits	2180	Shared Neighborhood Hits	6
SwissProt Accessions	Q7TT50, Q69ZR5, Q80W33	Gene names	Cdc42bpb, Kiaa1124
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MRCK beta (EC 2.7.11.1) (CDC42-binding protein kinase beta) (Myotonic dystrophy kinase-related CDC42-binding kinase beta) (Myotonic dystrophy protein kinase-like beta) (MRCK beta) (DMPK-like beta).