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Network neighborhood for query Sequence : DOK5_MOUSE

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DOK5_MOUSE
SwissProt Accessions	Q91ZM9, Q8BRI3, Q9CSM6	Gene names	Dok5
Domain Architecture
Description	Docking protein 5 (Downstream of tyrosine kinase 5) (Protein dok-5).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

DOK5_MOUSE
θ value	1.96665e-180 (rank : 1)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	27	Target Neighborhood Hits	27	Shared Neighborhood Hits	27
SwissProt Accessions	Q91ZM9, Q8BRI3, Q9CSM6	Gene names	Dok5
Domain Architecture
Description	Docking protein 5 (Downstream of tyrosine kinase 5) (Protein dok-5).

DOK5_HUMAN
θ value	2.03516e-177 (rank : 2)	NC score	0.999831 (rank : 2)
Query Neighborhood Hits	27	Target Neighborhood Hits	28	Shared Neighborhood Hits	27
SwissProt Accessions	Q9P104, Q5T7Y0, Q5TE53, Q8TEW7, Q96H13, Q9BZ24, Q9NQF4, Q9Y411	Gene names	DOK5, C20orf180
Domain Architecture
Description	Docking protein 5 (Downstream of tyrosine kinase 5) (IRS6) (Protein dok-5).

DOK6_HUMAN
θ value	1.93155e-127 (rank : 3)	NC score	0.994241 (rank : 3)
Query Neighborhood Hits	27	Target Neighborhood Hits	25	Shared Neighborhood Hits	23
SwissProt Accessions	Q6PKX4, Q4V9S3, Q8WUZ8, Q96HI2, Q96LU2	Gene names	DOK6, DOK5L
Domain Architecture	No domain graphic available
Description	Docking protein 6 (Downstream of tyrosine kinase 6).

DOK4_MOUSE
θ value	6.68496e-104 (rank : 4)	NC score	0.983307 (rank : 5)
Query Neighborhood Hits	27	Target Neighborhood Hits	30	Shared Neighborhood Hits	21
SwissProt Accessions	Q99KE3, Q3U0X3	Gene names	Dok4
Domain Architecture	No domain graphic available
Description	Docking protein 4 (Downstream of tyrosine kinase 4).

DOK4_HUMAN
θ value	2.54029e-103 (rank : 5)	NC score	0.984119 (rank : 4)
Query Neighborhood Hits	27	Target Neighborhood Hits	28	Shared Neighborhood Hits	21
SwissProt Accessions	Q8TEW6, O75209, Q9BTP2, Q9NVV3	Gene names	DOK4
Domain Architecture	No domain graphic available
Description	Docking protein 4 (Downstream of tyrosine kinase 4).

DOK1_HUMAN
θ value	2.0648e-12 (rank : 6)	NC score	0.582621 (rank : 7)
Query Neighborhood Hits	27	Target Neighborhood Hits	85	Shared Neighborhood Hits	18
SwissProt Accessions	Q99704, O43204, Q9UHG6	Gene names	DOK1
Domain Architecture
Description	Docking protein 1 (Downstream of tyrosine kinase 1) (p62(dok)) (pp62).

DOK2_MOUSE
θ value	2.28291e-11 (rank : 7)	NC score	0.543308 (rank : 9)
Query Neighborhood Hits	27	Target Neighborhood Hits	244	Shared Neighborhood Hits	20
SwissProt Accessions	O70469, O70272, Q99KL1	Gene names	Dok2, Frip
Domain Architecture
Description	Docking protein 2 (Downstream of tyrosine kinase 2) (p56(dok-2)) (Dok- related protein) (Dok-R) (IL-four receptor-interacting protein) (FRIP).

DOK2_HUMAN
θ value	1.133e-10 (rank : 8)	NC score	0.585577 (rank : 6)
Query Neighborhood Hits	27	Target Neighborhood Hits	46	Shared Neighborhood Hits	18
SwissProt Accessions	O60496	Gene names	DOK2
Domain Architecture
Description	Docking protein 2 (Downstream of tyrosine kinase 2) (p56(dok-2)).

DOK1_MOUSE
θ value	7.34386e-10 (rank : 9)	NC score	0.568768 (rank : 8)
Query Neighborhood Hits	27	Target Neighborhood Hits	82	Shared Neighborhood Hits	17
SwissProt Accessions	P97465, Q9R213	Gene names	Dok1, Dok
Domain Architecture
Description	Docking protein 1 (Downstream of tyrosine kinase 1) (p62(dok)).

IRS1_MOUSE
θ value	1.80886e-08 (rank : 10)	NC score	0.309853 (rank : 16)
Query Neighborhood Hits	27	Target Neighborhood Hits	112	Shared Neighborhood Hits	12
SwissProt Accessions	P35569	Gene names	Irs1, Irs-1
Domain Architecture
Description	Insulin receptor substrate 1 (IRS-1).

DOK3_HUMAN
θ value	3.08544e-08 (rank : 11)	NC score	0.509146 (rank : 11)
Query Neighborhood Hits	27	Target Neighborhood Hits	60	Shared Neighborhood Hits	17
SwissProt Accessions	Q7L591, Q8N864, Q9BQB3, Q9H666	Gene names	DOK3
Domain Architecture	No domain graphic available
Description	Docking protein 3 (Downstream of tyrosine kinase 3).

DOK3_MOUSE
θ value	6.87365e-08 (rank : 12)	NC score	0.533334 (rank : 10)
Query Neighborhood Hits	27	Target Neighborhood Hits	25	Shared Neighborhood Hits	18
SwissProt Accessions	Q9QZK7	Gene names	Dok3, Dokl
Domain Architecture	No domain graphic available
Description	Docking protein 3 (Downstream of tyrosine kinase 3) (P62(dok)-like protein) (DOK-L).

FRS3_HUMAN
θ value	3.41135e-07 (rank : 13)	NC score	0.453841 (rank : 12)
Query Neighborhood Hits	27	Target Neighborhood Hits	76	Shared Neighborhood Hits	17
SwissProt Accessions	O43559, Q5T3D5	Gene names	FRS3
Domain Architecture	No domain graphic available
Description	Fibroblast growth factor receptor substrate 3 (FGFR substrate 3) (Suc1-associated neurotrophic factor target 2) (SNT-2) (FGFR signaling adaptor SNT2).

FRS3_MOUSE
θ value	7.59969e-07 (rank : 14)	NC score	0.437842 (rank : 13)
Query Neighborhood Hits	27	Target Neighborhood Hits	168	Shared Neighborhood Hits	18
SwissProt Accessions	Q91WJ0	Gene names	Frs3, Frs2b
Domain Architecture	No domain graphic available
Description	Fibroblast growth factor receptor substrate 3 (FGFR substrate 3) (FRS2-beta).

FRS2_MOUSE
θ value	4.92598e-06 (rank : 15)	NC score	0.427712 (rank : 14)
Query Neighborhood Hits	27	Target Neighborhood Hits	41	Shared Neighborhood Hits	17
SwissProt Accessions	Q8C180	Gene names	Frs2, Frs2a
Domain Architecture	No domain graphic available
Description	Fibroblast growth factor receptor substrate 2 (FGFR substrate 2) (Suc1-associated neurotrophic factor target 1) (SNT-1) (FGFR signaling adaptor SNT) (FRS2 alpha).

IRS1_HUMAN
θ value	4.92598e-06 (rank : 16)	NC score	0.284636 (rank : 18)
Query Neighborhood Hits	27	Target Neighborhood Hits	109	Shared Neighborhood Hits	11
SwissProt Accessions	P35568	Gene names	IRS1
Domain Architecture
Description	Insulin receptor substrate 1 (IRS-1).

FRS2_HUMAN
θ value	6.43352e-06 (rank : 17)	NC score	0.427509 (rank : 15)
Query Neighborhood Hits	27	Target Neighborhood Hits	40	Shared Neighborhood Hits	19
SwissProt Accessions	Q8WU20, O43558, Q7LDQ6	Gene names	FRS2
Domain Architecture	No domain graphic available
Description	Fibroblast growth factor receptor substrate 2 (FGFR substrate 2) (Suc1-associated neurotrophic factor target 1) (SNT-1) (FGFR signaling adaptor SNT).

DOK7_HUMAN
θ value	0.00298849 (rank : 18)	NC score	0.295254 (rank : 17)
Query Neighborhood Hits	27	Target Neighborhood Hits	51	Shared Neighborhood Hits	17
SwissProt Accessions	Q18PE1, Q6P6A6, Q86XG5, Q8N2J3, Q8NBC1	Gene names	DOK7, C4orf25
Domain Architecture	No domain graphic available
Description	Protein Dok-7 (Downstream of tyrosine kinase 7).

DOK7_MOUSE
θ value	0.00390308 (rank : 19)	NC score	0.270934 (rank : 19)
Query Neighborhood Hits	27	Target Neighborhood Hits	169	Shared Neighborhood Hits	17
SwissProt Accessions	Q18PE0, Q3TCZ6, Q5FW70, Q8C8U7	Gene names	Dok7
Domain Architecture	No domain graphic available
Description	Protein Dok-7 (Downstream of tyrosine kinase 7).

IRS2_MOUSE
θ value	0.21417 (rank : 20)	NC score	0.145245 (rank : 20)
Query Neighborhood Hits	27	Target Neighborhood Hits	248	Shared Neighborhood Hits	9
SwissProt Accessions	P81122	Gene names	Irs2
Domain Architecture	No domain graphic available
Description	Insulin receptor substrate 2 (IRS-2) (4PS).

CDCP1_HUMAN
θ value	2.36792 (rank : 21)	NC score	0.031310 (rank : 24)
Query Neighborhood Hits	27	Target Neighborhood Hits	33	Shared Neighborhood Hits	3
SwissProt Accessions	Q9H5V8, Q49UB4, Q6NT71, Q6U9Y2, Q8WU91, Q96QU7, Q9H676, Q9H8C2	Gene names	CDCP1, TRASK
Domain Architecture	No domain graphic available
Description	CUB domain-containing protein 1 precursor (Transmembrane and associated with src kinases) (Membrane glycoprotein gp140) (Subtractive immunization M plus HEp3-associated 135 kDa protein) (SIMA135) (CD318 antigen).

GRB14_MOUSE
θ value	4.03905 (rank : 22)	NC score	0.015650 (rank : 25)
Query Neighborhood Hits	27	Target Neighborhood Hits	149	Shared Neighborhood Hits	4
SwissProt Accessions	Q9JLM9, Q3UI77, Q8VDI2, Q9CR03	Gene names	Grb14
Domain Architecture
Description	Growth factor receptor-bound protein 14 (GRB14 adapter protein).

IRS2_HUMAN
θ value	4.03905 (rank : 23)	NC score	0.123487 (rank : 21)
Query Neighborhood Hits	27	Target Neighborhood Hits	262	Shared Neighborhood Hits	9
SwissProt Accessions	Q9Y4H2, Q96RR2, Q9BZG0, Q9Y6I5	Gene names	IRS2
Domain Architecture
Description	Insulin receptor substrate 2 (IRS-2).

DPEP3_MOUSE
θ value	5.27518 (rank : 24)	NC score	0.015418 (rank : 26)
Query Neighborhood Hits	27	Target Neighborhood Hits	16	Shared Neighborhood Hits	3
SwissProt Accessions	Q9DA79	Gene names	Dpep3, Mbd3
Domain Architecture	No domain graphic available
Description	Dipeptidase 3 precursor (EC 3.4.13.19) (Membrane-bound dipeptidase 3) (MBD-3).

TLN2_HUMAN
θ value	5.27518 (rank : 25)	NC score	0.040688 (rank : 22)
Query Neighborhood Hits	27	Target Neighborhood Hits	157	Shared Neighborhood Hits	7
SwissProt Accessions	Q9Y4G6	Gene names	TLN2, KIAA0320
Domain Architecture
Description	Talin-2.

TLN2_MOUSE
θ value	5.27518 (rank : 26)	NC score	0.040007 (rank : 23)
Query Neighborhood Hits	27	Target Neighborhood Hits	149	Shared Neighborhood Hits	7
SwissProt Accessions	Q71LX4, Q8BWK0	Gene names	Tln2
Domain Architecture	No domain graphic available
Description	Talin-2.

GRB14_HUMAN
θ value	8.99809 (rank : 27)	NC score	0.012178 (rank : 27)
Query Neighborhood Hits	27	Target Neighborhood Hits	137	Shared Neighborhood Hits	4
SwissProt Accessions	Q14449, Q7Z6I1	Gene names	GRB14
Domain Architecture
Description	Growth factor receptor-bound protein 14 (GRB14 adapter protein).

Hits sorted by NC score

DOK5_MOUSE
NC score	0.999962 (rank : 1)	θ value	1.96665e-180 (rank : 1)
Query Neighborhood Hits	27	Target Neighborhood Hits	27	Shared Neighborhood Hits	27
SwissProt Accessions	Q91ZM9, Q8BRI3, Q9CSM6	Gene names	Dok5
Domain Architecture
Description	Docking protein 5 (Downstream of tyrosine kinase 5) (Protein dok-5).

DOK5_HUMAN
NC score	0.999831 (rank : 2)	θ value	2.03516e-177 (rank : 2)
Query Neighborhood Hits	27	Target Neighborhood Hits	28	Shared Neighborhood Hits	27
SwissProt Accessions	Q9P104, Q5T7Y0, Q5TE53, Q8TEW7, Q96H13, Q9BZ24, Q9NQF4, Q9Y411	Gene names	DOK5, C20orf180
Domain Architecture
Description	Docking protein 5 (Downstream of tyrosine kinase 5) (IRS6) (Protein dok-5).

DOK6_HUMAN
NC score	0.994241 (rank : 3)	θ value	1.93155e-127 (rank : 3)
Query Neighborhood Hits	27	Target Neighborhood Hits	25	Shared Neighborhood Hits	23
SwissProt Accessions	Q6PKX4, Q4V9S3, Q8WUZ8, Q96HI2, Q96LU2	Gene names	DOK6, DOK5L
Domain Architecture	No domain graphic available
Description	Docking protein 6 (Downstream of tyrosine kinase 6).

DOK4_HUMAN
NC score	0.984119 (rank : 4)	θ value	2.54029e-103 (rank : 5)
Query Neighborhood Hits	27	Target Neighborhood Hits	28	Shared Neighborhood Hits	21
SwissProt Accessions	Q8TEW6, O75209, Q9BTP2, Q9NVV3	Gene names	DOK4
Domain Architecture	No domain graphic available
Description	Docking protein 4 (Downstream of tyrosine kinase 4).

DOK4_MOUSE
NC score	0.983307 (rank : 5)	θ value	6.68496e-104 (rank : 4)
Query Neighborhood Hits	27	Target Neighborhood Hits	30	Shared Neighborhood Hits	21
SwissProt Accessions	Q99KE3, Q3U0X3	Gene names	Dok4
Domain Architecture	No domain graphic available
Description	Docking protein 4 (Downstream of tyrosine kinase 4).

DOK2_HUMAN
NC score	0.585577 (rank : 6)	θ value	1.133e-10 (rank : 8)
Query Neighborhood Hits	27	Target Neighborhood Hits	46	Shared Neighborhood Hits	18
SwissProt Accessions	O60496	Gene names	DOK2
Domain Architecture
Description	Docking protein 2 (Downstream of tyrosine kinase 2) (p56(dok-2)).

DOK1_HUMAN
NC score	0.582621 (rank : 7)	θ value	2.0648e-12 (rank : 6)
Query Neighborhood Hits	27	Target Neighborhood Hits	85	Shared Neighborhood Hits	18
SwissProt Accessions	Q99704, O43204, Q9UHG6	Gene names	DOK1
Domain Architecture
Description	Docking protein 1 (Downstream of tyrosine kinase 1) (p62(dok)) (pp62).

DOK1_MOUSE
NC score	0.568768 (rank : 8)	θ value	7.34386e-10 (rank : 9)
Query Neighborhood Hits	27	Target Neighborhood Hits	82	Shared Neighborhood Hits	17
SwissProt Accessions	P97465, Q9R213	Gene names	Dok1, Dok
Domain Architecture
Description	Docking protein 1 (Downstream of tyrosine kinase 1) (p62(dok)).

DOK2_MOUSE
NC score	0.543308 (rank : 9)	θ value	2.28291e-11 (rank : 7)
Query Neighborhood Hits	27	Target Neighborhood Hits	244	Shared Neighborhood Hits	20
SwissProt Accessions	O70469, O70272, Q99KL1	Gene names	Dok2, Frip
Domain Architecture
Description	Docking protein 2 (Downstream of tyrosine kinase 2) (p56(dok-2)) (Dok- related protein) (Dok-R) (IL-four receptor-interacting protein) (FRIP).

DOK3_MOUSE
NC score	0.533334 (rank : 10)	θ value	6.87365e-08 (rank : 12)
Query Neighborhood Hits	27	Target Neighborhood Hits	25	Shared Neighborhood Hits	18
SwissProt Accessions	Q9QZK7	Gene names	Dok3, Dokl
Domain Architecture	No domain graphic available
Description	Docking protein 3 (Downstream of tyrosine kinase 3) (P62(dok)-like protein) (DOK-L).

DOK3_HUMAN
NC score	0.509146 (rank : 11)	θ value	3.08544e-08 (rank : 11)
Query Neighborhood Hits	27	Target Neighborhood Hits	60	Shared Neighborhood Hits	17
SwissProt Accessions	Q7L591, Q8N864, Q9BQB3, Q9H666	Gene names	DOK3
Domain Architecture	No domain graphic available
Description	Docking protein 3 (Downstream of tyrosine kinase 3).

FRS3_HUMAN
NC score	0.453841 (rank : 12)	θ value	3.41135e-07 (rank : 13)
Query Neighborhood Hits	27	Target Neighborhood Hits	76	Shared Neighborhood Hits	17
SwissProt Accessions	O43559, Q5T3D5	Gene names	FRS3
Domain Architecture	No domain graphic available
Description	Fibroblast growth factor receptor substrate 3 (FGFR substrate 3) (Suc1-associated neurotrophic factor target 2) (SNT-2) (FGFR signaling adaptor SNT2).

FRS3_MOUSE
NC score	0.437842 (rank : 13)	θ value	7.59969e-07 (rank : 14)
Query Neighborhood Hits	27	Target Neighborhood Hits	168	Shared Neighborhood Hits	18
SwissProt Accessions	Q91WJ0	Gene names	Frs3, Frs2b
Domain Architecture	No domain graphic available
Description	Fibroblast growth factor receptor substrate 3 (FGFR substrate 3) (FRS2-beta).

FRS2_MOUSE
NC score	0.427712 (rank : 14)	θ value	4.92598e-06 (rank : 15)
Query Neighborhood Hits	27	Target Neighborhood Hits	41	Shared Neighborhood Hits	17
SwissProt Accessions	Q8C180	Gene names	Frs2, Frs2a
Domain Architecture	No domain graphic available
Description	Fibroblast growth factor receptor substrate 2 (FGFR substrate 2) (Suc1-associated neurotrophic factor target 1) (SNT-1) (FGFR signaling adaptor SNT) (FRS2 alpha).

FRS2_HUMAN
NC score	0.427509 (rank : 15)	θ value	6.43352e-06 (rank : 17)
Query Neighborhood Hits	27	Target Neighborhood Hits	40	Shared Neighborhood Hits	19
SwissProt Accessions	Q8WU20, O43558, Q7LDQ6	Gene names	FRS2
Domain Architecture	No domain graphic available
Description	Fibroblast growth factor receptor substrate 2 (FGFR substrate 2) (Suc1-associated neurotrophic factor target 1) (SNT-1) (FGFR signaling adaptor SNT).

IRS1_MOUSE
NC score	0.309853 (rank : 16)	θ value	1.80886e-08 (rank : 10)
Query Neighborhood Hits	27	Target Neighborhood Hits	112	Shared Neighborhood Hits	12
SwissProt Accessions	P35569	Gene names	Irs1, Irs-1
Domain Architecture
Description	Insulin receptor substrate 1 (IRS-1).

DOK7_HUMAN
NC score	0.295254 (rank : 17)	θ value	0.00298849 (rank : 18)
Query Neighborhood Hits	27	Target Neighborhood Hits	51	Shared Neighborhood Hits	17
SwissProt Accessions	Q18PE1, Q6P6A6, Q86XG5, Q8N2J3, Q8NBC1	Gene names	DOK7, C4orf25
Domain Architecture	No domain graphic available
Description	Protein Dok-7 (Downstream of tyrosine kinase 7).

IRS1_HUMAN
NC score	0.284636 (rank : 18)	θ value	4.92598e-06 (rank : 16)
Query Neighborhood Hits	27	Target Neighborhood Hits	109	Shared Neighborhood Hits	11
SwissProt Accessions	P35568	Gene names	IRS1
Domain Architecture
Description	Insulin receptor substrate 1 (IRS-1).

DOK7_MOUSE
NC score	0.270934 (rank : 19)	θ value	0.00390308 (rank : 19)
Query Neighborhood Hits	27	Target Neighborhood Hits	169	Shared Neighborhood Hits	17
SwissProt Accessions	Q18PE0, Q3TCZ6, Q5FW70, Q8C8U7	Gene names	Dok7
Domain Architecture	No domain graphic available
Description	Protein Dok-7 (Downstream of tyrosine kinase 7).

IRS2_MOUSE
NC score	0.145245 (rank : 20)	θ value	0.21417 (rank : 20)
Query Neighborhood Hits	27	Target Neighborhood Hits	248	Shared Neighborhood Hits	9
SwissProt Accessions	P81122	Gene names	Irs2
Domain Architecture	No domain graphic available
Description	Insulin receptor substrate 2 (IRS-2) (4PS).

IRS2_HUMAN
NC score	0.123487 (rank : 21)	θ value	4.03905 (rank : 23)
Query Neighborhood Hits	27	Target Neighborhood Hits	262	Shared Neighborhood Hits	9
SwissProt Accessions	Q9Y4H2, Q96RR2, Q9BZG0, Q9Y6I5	Gene names	IRS2
Domain Architecture
Description	Insulin receptor substrate 2 (IRS-2).

TLN2_HUMAN
NC score	0.040688 (rank : 22)	θ value	5.27518 (rank : 25)
Query Neighborhood Hits	27	Target Neighborhood Hits	157	Shared Neighborhood Hits	7
SwissProt Accessions	Q9Y4G6	Gene names	TLN2, KIAA0320
Domain Architecture
Description	Talin-2.

TLN2_MOUSE
NC score	0.040007 (rank : 23)	θ value	5.27518 (rank : 26)
Query Neighborhood Hits	27	Target Neighborhood Hits	149	Shared Neighborhood Hits	7
SwissProt Accessions	Q71LX4, Q8BWK0	Gene names	Tln2
Domain Architecture	No domain graphic available
Description	Talin-2.

CDCP1_HUMAN
NC score	0.031310 (rank : 24)	θ value	2.36792 (rank : 21)
Query Neighborhood Hits	27	Target Neighborhood Hits	33	Shared Neighborhood Hits	3
SwissProt Accessions	Q9H5V8, Q49UB4, Q6NT71, Q6U9Y2, Q8WU91, Q96QU7, Q9H676, Q9H8C2	Gene names	CDCP1, TRASK
Domain Architecture	No domain graphic available
Description	CUB domain-containing protein 1 precursor (Transmembrane and associated with src kinases) (Membrane glycoprotein gp140) (Subtractive immunization M plus HEp3-associated 135 kDa protein) (SIMA135) (CD318 antigen).

GRB14_MOUSE
NC score	0.015650 (rank : 25)	θ value	4.03905 (rank : 22)
Query Neighborhood Hits	27	Target Neighborhood Hits	149	Shared Neighborhood Hits	4
SwissProt Accessions	Q9JLM9, Q3UI77, Q8VDI2, Q9CR03	Gene names	Grb14
Domain Architecture
Description	Growth factor receptor-bound protein 14 (GRB14 adapter protein).

DPEP3_MOUSE
NC score	0.015418 (rank : 26)	θ value	5.27518 (rank : 24)
Query Neighborhood Hits	27	Target Neighborhood Hits	16	Shared Neighborhood Hits	3
SwissProt Accessions	Q9DA79	Gene names	Dpep3, Mbd3
Domain Architecture	No domain graphic available
Description	Dipeptidase 3 precursor (EC 3.4.13.19) (Membrane-bound dipeptidase 3) (MBD-3).

GRB14_HUMAN
NC score	0.012178 (rank : 27)	θ value	8.99809 (rank : 27)
Query Neighborhood Hits	27	Target Neighborhood Hits	137	Shared Neighborhood Hits	4
SwissProt Accessions	Q14449, Q7Z6I1	Gene names	GRB14
Domain Architecture
Description	Growth factor receptor-bound protein 14 (GRB14 adapter protein).