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Network neighborhood for query Sequence : ANPRC_MOUSE

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ANPRC_MOUSE
SwissProt Accessions	P70180, P97804, Q9R025, Q9R027, Q9R028	Gene names	Npr3
Domain Architecture
Description	Atrial natriuretic peptide clearance receptor precursor (ANP-C) (ANPRC) (NPR-C) (Atrial natriuretic peptide C-type receptor) (EF-2).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

ANPRC_HUMAN
θ value	0 (rank : 1)	NC score	0.996091 (rank : 2)
Query Neighborhood Hits	27	Target Neighborhood Hits	27	Shared Neighborhood Hits	22
SwissProt Accessions	P17342	Gene names	NPR3, ANPRC
Domain Architecture
Description	Atrial natriuretic peptide clearance receptor precursor (ANP-C) (ANPRC) (NPR-C) (Atrial natriuretic peptide C-type receptor).

ANPRC_MOUSE
θ value	0 (rank : 2)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	27	Target Neighborhood Hits	27	Shared Neighborhood Hits	27
SwissProt Accessions	P70180, P97804, Q9R025, Q9R027, Q9R028	Gene names	Npr3
Domain Architecture
Description	Atrial natriuretic peptide clearance receptor precursor (ANP-C) (ANPRC) (NPR-C) (Atrial natriuretic peptide C-type receptor) (EF-2).

ANPRA_MOUSE
θ value	7.49467e-55 (rank : 3)	NC score	0.379782 (rank : 5)
Query Neighborhood Hits	27	Target Neighborhood Hits	600	Shared Neighborhood Hits	14
SwissProt Accessions	P18293	Gene names	Npr1, Npra
Domain Architecture
Description	Atrial natriuretic peptide receptor A precursor (ANP-A) (ANPRA) (GC-A) (Guanylate cyclase) (EC 4.6.1.2) (NPR-A) (Atrial natriuretic peptide A-type receptor).

ANPRA_HUMAN
θ value	4.85792e-54 (rank : 4)	NC score	0.380231 (rank : 4)
Query Neighborhood Hits	27	Target Neighborhood Hits	612	Shared Neighborhood Hits	16
SwissProt Accessions	P16066, Q6P4Q3	Gene names	NPR1, ANPRA
Domain Architecture
Description	Atrial natriuretic peptide receptor A precursor (ANP-A) (ANPRA) (GC-A) (Guanylate cyclase) (EC 4.6.1.2) (NPR-A) (Atrial natriuretic peptide A-type receptor).

ANPRB_MOUSE
θ value	2.3352e-48 (rank : 5)	NC score	0.386577 (rank : 3)
Query Neighborhood Hits	27	Target Neighborhood Hits	607	Shared Neighborhood Hits	14
SwissProt Accessions	Q6VVW5, Q6VVW3, Q6VVW4, Q8CGA9	Gene names	Npr2
Domain Architecture	No domain graphic available
Description	Atrial natriuretic peptide receptor B precursor (ANP-B) (ANPRB) (GC-B) (Guanylate cyclase B) (EC 4.6.1.2) (NPR-B) (Atrial natriuretic peptide B-type receptor).

ANPRB_HUMAN
θ value	6.7944e-48 (rank : 6)	NC score	0.372398 (rank : 6)
Query Neighborhood Hits	27	Target Neighborhood Hits	646	Shared Neighborhood Hits	14
SwissProt Accessions	P20594, O60871, Q9UQ50	Gene names	NPR2, ANPRB
Domain Architecture
Description	Atrial natriuretic peptide receptor B precursor (ANP-B) (ANPRB) (GC-B) (Guanylate cyclase B) (EC 4.6.1.2) (NPR-B) (Atrial natriuretic peptide B-type receptor).

GUC2G_MOUSE
θ value	1.99529e-15 (rank : 7)	NC score	0.309747 (rank : 9)
Query Neighborhood Hits	27	Target Neighborhood Hits	644	Shared Neighborhood Hits	23
SwissProt Accessions	Q6TL19, Q8BWU7	Gene names	Gucy2g
Domain Architecture	No domain graphic available
Description	Guanylate cyclase 2G precursor (EC 4.6.1.2) (Guanylyl cyclase receptor G) (mGC-G).

GUC2F_HUMAN
θ value	7.59969e-07 (rank : 8)	NC score	0.244596 (rank : 18)
Query Neighborhood Hits	27	Target Neighborhood Hits	740	Shared Neighborhood Hits	15
SwissProt Accessions	P51841, Q9UJF1	Gene names	GUCY2F, GUC2F, RETGC2
Domain Architecture
Description	Retinal guanylyl cyclase 2 precursor (EC 4.6.1.2) (Guanylate cyclase 2F, retinal) (RETGC-2) (Rod outer segment membrane guanylate cyclase 2) (ROS-GC2) (Guanylate cyclase F) (GC-F).

MGR1_MOUSE
θ value	2.21117e-06 (rank : 9)	NC score	0.157327 (rank : 25)
Query Neighborhood Hits	27	Target Neighborhood Hits	90	Shared Neighborhood Hits	20
SwissProt Accessions	P97772, Q6AXG4, Q9EPV6	Gene names	Grm1, Gprc1a, Mglur1
Domain Architecture
Description	Metabotropic glutamate receptor 1 precursor (mGluR1).

MGR1_HUMAN
θ value	3.77169e-06 (rank : 10)	NC score	0.155895 (rank : 26)
Query Neighborhood Hits	27	Target Neighborhood Hits	85	Shared Neighborhood Hits	20
SwissProt Accessions	Q13255, Q13256, Q14757, Q14758, Q5VTF7, Q5VTF8, Q9NU10, Q9UGS9, Q9UGT0	Gene names	GRM1, GPRC1A, MGLUR1
Domain Architecture
Description	Metabotropic glutamate receptor 1 precursor (mGluR1).

GABR1_MOUSE
θ value	6.43352e-06 (rank : 11)	NC score	0.349740 (rank : 7)
Query Neighborhood Hits	27	Target Neighborhood Hits	139	Shared Neighborhood Hits	21
SwissProt Accessions	Q9WV18, Q9WU48, Q9WV15, Q9WV16, Q9WV17	Gene names	Gabbr1
Domain Architecture
Description	Gamma-aminobutyric acid type B receptor, subunit 1 precursor (GABA-B receptor 1) (GABA-B-R1) (Gb1).

GABR1_HUMAN
θ value	1.09739e-05 (rank : 12)	NC score	0.343154 (rank : 8)
Query Neighborhood Hits	27	Target Neighborhood Hits	142	Shared Neighborhood Hits	21
SwissProt Accessions	Q9UBS5, O95375, O95468, O95975, O96022, Q86W60, Q9UQQ0	Gene names	GABBR1, GPRC3A
Domain Architecture
Description	Gamma-aminobutyric acid type B receptor, subunit 1 precursor (GABA-B receptor 1) (GABA-B-R1) (Gb1).

GABR2_HUMAN
θ value	3.19293e-05 (rank : 13)	NC score	0.247306 (rank : 17)
Query Neighborhood Hits	27	Target Neighborhood Hits	101	Shared Neighborhood Hits	20
SwissProt Accessions	O75899, O75974, O75975, Q5VXZ2, Q8WX04, Q9P1R2, Q9UNR1, Q9UNS9	Gene names	GABBR2, GPR51, GPRC3B
Domain Architecture
Description	Gamma-aminobutyric acid type B receptor, subunit 2 precursor (GABA-B receptor 2) (GABA-B-R2) (Gb2) (GABABR2) (G-protein coupled receptor 51) (HG20).

MGR5_HUMAN
θ value	0.000158464 (rank : 14)	NC score	0.146310 (rank : 37)
Query Neighborhood Hits	27	Target Neighborhood Hits	72	Shared Neighborhood Hits	20
SwissProt Accessions	P41594	Gene names	GRM5, GPRC1E, MGLUR5
Domain Architecture
Description	Metabotropic glutamate receptor 5 precursor (mGluR5).

NMDZ1_HUMAN
θ value	0.00869519 (rank : 15)	NC score	0.086693 (rank : 59)
Query Neighborhood Hits	27	Target Neighborhood Hits	77	Shared Neighborhood Hits	20
SwissProt Accessions	Q05586, P35437, Q12867, Q12868	Gene names	GRIN1, NMDAR1
Domain Architecture
Description	Glutamate [NMDA] receptor subunit zeta 1 precursor (N-methyl-D- aspartate receptor subunit NR1).

NMDZ1_MOUSE
θ value	0.00869519 (rank : 16)	NC score	0.087017 (rank : 57)
Query Neighborhood Hits	27	Target Neighborhood Hits	76	Shared Neighborhood Hits	19
SwissProt Accessions	P35438, Q8CFS4	Gene names	Grin1, Glurz1
Domain Architecture
Description	Glutamate [NMDA] receptor subunit zeta 1 precursor (N-methyl-D- aspartate receptor subunit NR1).

MGR4_HUMAN
θ value	0.0736092 (rank : 17)	NC score	0.123566 (rank : 40)
Query Neighborhood Hits	27	Target Neighborhood Hits	63	Shared Neighborhood Hits	18
SwissProt Accessions	Q14833, Q5SZ84	Gene names	GRM4, GPRC1D, MGLUR4
Domain Architecture
Description	Metabotropic glutamate receptor 4 precursor (mGluR4).

GUC2D_HUMAN
θ value	0.125558 (rank : 18)	NC score	0.250806 (rank : 16)
Query Neighborhood Hits	27	Target Neighborhood Hits	715	Shared Neighborhood Hits	10
SwissProt Accessions	Q02846, Q6LEA7	Gene names	GUCY2D, CORD6, GUC1A4, GUC2D, RETGC, RETGC1
Domain Architecture
Description	Retinal guanylyl cyclase 1 precursor (EC 4.6.1.2) (Guanylate cyclase 2D, retinal) (RETGC-1) (Rod outer segment membrane guanylate cyclase) (ROS-GC).

GRIK1_HUMAN
θ value	1.06291 (rank : 19)	NC score	0.040299 (rank : 94)
Query Neighborhood Hits	27	Target Neighborhood Hits	48	Shared Neighborhood Hits	10
SwissProt Accessions	P39086, Q13001, Q86SU9	Gene names	GRIK1, GLUR5
Domain Architecture
Description	Glutamate receptor, ionotropic kainate 1 precursor (Glutamate receptor 5) (GluR-5) (GluR5) (Excitatory amino acid receptor 3) (EAA3).

TS1R2_MOUSE
θ value	1.38821 (rank : 20)	NC score	0.112788 (rank : 42)
Query Neighborhood Hits	27	Target Neighborhood Hits	69	Shared Neighborhood Hits	22
SwissProt Accessions	Q925I4, Q923J8	Gene names	Tas1r2, Gpr71, T1r2, Tr2
Domain Architecture	No domain graphic available
Description	Taste receptor type 1 member 2 precursor (G-protein coupled receptor 71) (Sweet taste receptor T1R2).

MGR6_MOUSE
θ value	2.36792 (rank : 21)	NC score	0.107534 (rank : 45)
Query Neighborhood Hits	27	Target Neighborhood Hits	56	Shared Neighborhood Hits	17
SwissProt Accessions	Q5NCH9	Gene names	Grm6, Gprc1f, Mglur6
Domain Architecture	No domain graphic available
Description	Metabotropic glutamate receptor 6 precursor (mGluR6).

GRIK1_MOUSE
θ value	3.0926 (rank : 22)	NC score	0.037689 (rank : 95)
Query Neighborhood Hits	27	Target Neighborhood Hits	46	Shared Neighborhood Hits	10
SwissProt Accessions	Q60934	Gene names	Grik1, Glur5
Domain Architecture
Description	Glutamate receptor, ionotropic kainate 1 precursor (Glutamate receptor 5) (GluR-5) (GluR5).

MGR6_HUMAN
θ value	3.0926 (rank : 23)	NC score	0.107027 (rank : 46)
Query Neighborhood Hits	27	Target Neighborhood Hits	58	Shared Neighborhood Hits	17
SwissProt Accessions	O15303	Gene names	GRM6, GPRC1F, MGLUR6
Domain Architecture
Description	Metabotropic glutamate receptor 6 precursor (mGluR6).

GUC2E_MOUSE
θ value	4.03905 (rank : 24)	NC score	0.241782 (rank : 19)
Query Neighborhood Hits	27	Target Neighborhood Hits	692	Shared Neighborhood Hits	9
SwissProt Accessions	P52785	Gene names	Gucy2e, Guc2e
Domain Architecture
Description	Guanylyl cyclase GC-E precursor (EC 4.6.1.2) (Guanylate cyclase 2E).

MGR8_HUMAN
θ value	4.03905 (rank : 25)	NC score	0.108421 (rank : 43)
Query Neighborhood Hits	27	Target Neighborhood Hits	49	Shared Neighborhood Hits	17
SwissProt Accessions	O00222, O15493, O95945, O95946, Q3MIV9, Q52M02, Q6J165	Gene names	GRM8, GPRC1H, MGLUR8
Domain Architecture
Description	Metabotropic glutamate receptor 8 precursor (mGluR8).

MGR8_MOUSE
θ value	4.03905 (rank : 26)	NC score	0.108274 (rank : 44)
Query Neighborhood Hits	27	Target Neighborhood Hits	44	Shared Neighborhood Hits	17
SwissProt Accessions	P47743, Q6B964	Gene names	Grm8, Gprc1h, Mglur8
Domain Architecture
Description	Metabotropic glutamate receptor 8 precursor (mGluR8).

TS1R1_HUMAN
θ value	4.03905 (rank : 27)	NC score	0.115279 (rank : 41)
Query Neighborhood Hits	27	Target Neighborhood Hits	72	Shared Neighborhood Hits	22
SwissProt Accessions	Q7RTX1, Q8NGZ7, Q8TDJ7, Q8TDJ8, Q8TDJ9, Q8TDK0	Gene names	TAS1R1, GPR70, T1R1, TR1
Domain Architecture	No domain graphic available
Description	Taste receptor type 1 member 1 precursor (G-protein coupled receptor 70) (Gm148).

ADCY1_HUMAN
θ value	θ > 10 (rank : 28)	NC score	0.154128 (rank : 29)
Query Neighborhood Hits	27	Target Neighborhood Hits	42	Shared Neighborhood Hits	8
SwissProt Accessions	Q08828, Q75MI1	Gene names	ADCY1
Domain Architecture	No domain graphic available
Description	Adenylate cyclase type 1 (EC 4.6.1.1) (Adenylate cyclase type I) (ATP pyrophosphate-lyase 1) (Ca(2+)/calmodulin-activated adenylyl cyclase).

ADCY1_MOUSE
θ value	θ > 10 (rank : 29)	NC score	0.152746 (rank : 32)
Query Neighborhood Hits	27	Target Neighborhood Hits	40	Shared Neighborhood Hits	8
SwissProt Accessions	O88444, Q5SS89	Gene names	Adcy1
Domain Architecture	No domain graphic available
Description	Adenylate cyclase type 1 (EC 4.6.1.1) (Adenylate cyclase type I) (ATP pyrophosphate-lyase 1) (Ca(2+)/calmodulin-activated adenylyl cyclase).

ADCY2_HUMAN
θ value	θ > 10 (rank : 30)	NC score	0.145947 (rank : 38)
Query Neighborhood Hits	27	Target Neighborhood Hits	38	Shared Neighborhood Hits	8
SwissProt Accessions	Q08462, Q9UPU2	Gene names	ADCY2, KIAA1060
Domain Architecture
Description	Adenylate cyclase type 2 (EC 4.6.1.1) (Adenylate cyclase type II) (ATP pyrophosphate-lyase 2) (Adenylyl cyclase 2).

ADCY2_MOUSE
θ value	θ > 10 (rank : 31)	NC score	0.143895 (rank : 39)
Query Neighborhood Hits	27	Target Neighborhood Hits	38	Shared Neighborhood Hits	8
SwissProt Accessions	Q80TL1, Q8CFU6	Gene names	Adcy2, Kiaa1060
Domain Architecture	No domain graphic available
Description	Adenylate cyclase type 2 (EC 4.6.1.1) (Adenylate cyclase type II) (ATP pyrophosphate-lyase 2) (Adenylyl cyclase 2).

ADCY3_HUMAN
θ value	θ > 10 (rank : 32)	NC score	0.160455 (rank : 24)
Query Neighborhood Hits	27	Target Neighborhood Hits	58	Shared Neighborhood Hits	8
SwissProt Accessions	O60266, Q9UDB1	Gene names	ADCY3, KIAA0511
Domain Architecture
Description	Adenylate cyclase type 3 (EC 4.6.1.1) (Adenylate cyclase type III) (Adenylate cyclase, olfactive type) (ATP pyrophosphate-lyase 3) (Adenylyl cyclase 3) (AC-III) (AC3).

ADCY3_MOUSE
θ value	θ > 10 (rank : 33)	NC score	0.162850 (rank : 23)
Query Neighborhood Hits	27	Target Neighborhood Hits	47	Shared Neighborhood Hits	8
SwissProt Accessions	Q8VHH7	Gene names	Adcy3
Domain Architecture
Description	Adenylate cyclase type 3 (EC 4.6.1.1) (Adenylate cyclase type III) (Adenylate cyclase, olfactive type) (ATP pyrophosphate-lyase 3) (Adenylyl cyclase 3) (AC-III) (AC3).

ADCY4_HUMAN
θ value	θ > 10 (rank : 34)	NC score	0.149652 (rank : 36)
Query Neighborhood Hits	27	Target Neighborhood Hits	41	Shared Neighborhood Hits	8
SwissProt Accessions	Q8NFM4, Q96ML7	Gene names	ADCY4
Domain Architecture
Description	Adenylate cyclase type 4 (EC 4.6.1.1) (Adenylate cyclase type IV) (ATP pyrophosphate-lyase 4) (Adenylyl cyclase 4).

ADCY4_MOUSE
θ value	θ > 10 (rank : 35)	NC score	0.151798 (rank : 33)
Query Neighborhood Hits	27	Target Neighborhood Hits	40	Shared Neighborhood Hits	8
SwissProt Accessions	Q91WF3	Gene names	Adcy4
Domain Architecture
Description	Adenylate cyclase type 4 (EC 4.6.1.1) (Adenylate cyclase type IV) (ATP pyrophosphate-lyase 4) (Adenylyl cyclase 4).

ADCY6_HUMAN
θ value	θ > 10 (rank : 36)	NC score	0.153913 (rank : 31)
Query Neighborhood Hits	27	Target Neighborhood Hits	52	Shared Neighborhood Hits	8
SwissProt Accessions	O43306, Q9NR75	Gene names	ADCY6, KIAA0422
Domain Architecture
Description	Adenylate cyclase type 6 (EC 4.6.1.1) (Adenylate cyclase type VI) (ATP pyrophosphate-lyase 6) (Ca(2+)-inhibitable adenylyl cyclase).

ADCY6_MOUSE
θ value	θ > 10 (rank : 37)	NC score	0.154065 (rank : 30)
Query Neighborhood Hits	27	Target Neighborhood Hits	57	Shared Neighborhood Hits	8
SwissProt Accessions	Q01341	Gene names	Adcy6
Domain Architecture
Description	Adenylate cyclase type 6 (EC 4.6.1.1) (Adenylate cyclase type VI) (ATP pyrophosphate-lyase 6) (Ca(2+)-inhibitable adenylyl cyclase).

ADCY7_HUMAN
θ value	θ > 10 (rank : 38)	NC score	0.150192 (rank : 35)
Query Neighborhood Hits	27	Target Neighborhood Hits	44	Shared Neighborhood Hits	8
SwissProt Accessions	P51828	Gene names	ADCY7, KIAA0037
Domain Architecture	No domain graphic available
Description	Adenylate cyclase type 7 (EC 4.6.1.1) (Adenylate cyclase type VII) (ATP pyrophosphate-lyase 7) (Adenylyl cyclase 7).

ADCY7_MOUSE
θ value	θ > 10 (rank : 39)	NC score	0.150685 (rank : 34)
Query Neighborhood Hits	27	Target Neighborhood Hits	37	Shared Neighborhood Hits	8
SwissProt Accessions	P51829	Gene names	Adcy7
Domain Architecture
Description	Adenylate cyclase type 7 (EC 4.6.1.1) (Adenylate cyclase type VII) (ATP pyrophosphate-lyase 7) (Adenylyl cyclase 7).

ADCY8_HUMAN
θ value	θ > 10 (rank : 40)	NC score	0.154504 (rank : 27)
Query Neighborhood Hits	27	Target Neighborhood Hits	41	Shared Neighborhood Hits	8
SwissProt Accessions	P40145	Gene names	ADCY8
Domain Architecture
Description	Adenylate cyclase type 8 (EC 4.6.1.1) (Adenylate cyclase type VIII) (ATP pyrophosphate-lyase 8) (Ca(2+)/calmodulin-activated adenylyl cyclase).

ADCY8_MOUSE
θ value	θ > 10 (rank : 41)	NC score	0.154500 (rank : 28)
Query Neighborhood Hits	27	Target Neighborhood Hits	42	Shared Neighborhood Hits	8
SwissProt Accessions	P97490	Gene names	Adcy8
Domain Architecture
Description	Adenylate cyclase type 8 (EC 4.6.1.1) (Adenylate cyclase type VIII) (ATP pyrophosphate-lyase 8) (Ca(2+)/calmodulin-activated adenylyl cyclase).

ADCY9_HUMAN
θ value	θ > 10 (rank : 42)	NC score	0.179721 (rank : 21)
Query Neighborhood Hits	27	Target Neighborhood Hits	51	Shared Neighborhood Hits	8
SwissProt Accessions	O60503, O60273, Q4ZHT9, Q4ZIR5, Q9BWT4, Q9UGP2	Gene names	ADCY9, KIAA0520
Domain Architecture
Description	Adenylate cyclase type 9 (EC 4.6.1.1) (Adenylate cyclase type IX) (ATP pyrophosphate-lyase 9) (Adenylyl cyclase 9).

ADCY9_MOUSE
θ value	θ > 10 (rank : 43)	NC score	0.179237 (rank : 22)
Query Neighborhood Hits	27	Target Neighborhood Hits	46	Shared Neighborhood Hits	8
SwissProt Accessions	P51830, Q61279	Gene names	Adcy9
Domain Architecture
Description	Adenylate cyclase type 9 (EC 4.6.1.1) (Adenylate cyclase type IX) (ATP pyrophosphate-lyase 9) (Adenylyl cyclase 9) (Adenylyl cyclase type 10) (ACTP10).

ANKK1_HUMAN
θ value	θ > 10 (rank : 44)	NC score	0.054697 (rank : 83)
Query Neighborhood Hits	27	Target Neighborhood Hits	1075	Shared Neighborhood Hits	8
SwissProt Accessions	Q8NFD2	Gene names	ANKK1, PKK2
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and protein kinase domain-containing protein 1 (EC 2.7.11.1) (Protein kinase PKK2) (X-kinase) (SgK288).

ANKK1_MOUSE
θ value	θ > 10 (rank : 45)	NC score	0.050193 (rank : 93)
Query Neighborhood Hits	27	Target Neighborhood Hits	1072	Shared Neighborhood Hits	8
SwissProt Accessions	Q8BZ25	Gene names	Ankk1
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and protein kinase domain-containing protein 1 (EC 2.7.11.1).

CASR_HUMAN
θ value	θ > 10 (rank : 46)	NC score	0.091967 (rank : 54)
Query Neighborhood Hits	27	Target Neighborhood Hits	71	Shared Neighborhood Hits	18
SwissProt Accessions	P41180, Q13912, Q16108, Q16109, Q16110, Q16379, Q4PJ19	Gene names	CASR, GPRC2A, PCAR1
Domain Architecture
Description	Extracellular calcium-sensing receptor precursor (CaSR) (Parathyroid Cell calcium-sensing receptor).

CASR_MOUSE
θ value	θ > 10 (rank : 47)	NC score	0.091685 (rank : 55)
Query Neighborhood Hits	27	Target Neighborhood Hits	72	Shared Neighborhood Hits	18
SwissProt Accessions	Q9QY96, O08968, O88519, Q9QY95, Q9QZU8, Q9R1D6, Q9R1Y2	Gene names	Casr, Gprc2a
Domain Architecture
Description	Extracellular calcium-sensing receptor precursor (CaSR) (Parathyroid Cell calcium-sensing receptor).

GCYA2_HUMAN
θ value	θ > 10 (rank : 48)	NC score	0.260992 (rank : 11)
Query Neighborhood Hits	27	Target Neighborhood Hits	50	Shared Neighborhood Hits	8
SwissProt Accessions	P33402	Gene names	GUCY1A2, GUC1A2, GUCSA2
Domain Architecture
Description	Guanylate cyclase soluble subunit alpha-2 (EC 4.6.1.2) (GCS-alpha-2).

GCYA3_HUMAN
θ value	θ > 10 (rank : 49)	NC score	0.254069 (rank : 15)
Query Neighborhood Hits	27	Target Neighborhood Hits	36	Shared Neighborhood Hits	8
SwissProt Accessions	Q02108, O43843, Q8TAH3	Gene names	GUCY1A3, GUC1A3, GUCSA3, GUCY1A1
Domain Architecture
Description	Guanylate cyclase soluble subunit alpha-3 (EC 4.6.1.2) (GCS-alpha-3) (Soluble guanylate cyclase large subunit) (GCS-alpha-1).

GCYA3_MOUSE
θ value	θ > 10 (rank : 50)	NC score	0.254607 (rank : 14)
Query Neighborhood Hits	27	Target Neighborhood Hits	41	Shared Neighborhood Hits	8
SwissProt Accessions	Q9ERL9, Q9DBQ3	Gene names	Gucy1a3, Gucy1a1
Domain Architecture
Description	Guanylate cyclase soluble subunit alpha-3 (EC 4.6.1.2) (GCS-alpha-3) (Soluble guanylate cyclase large subunit) (GCS-alpha-1).

GCYB1_HUMAN
θ value	θ > 10 (rank : 51)	NC score	0.258534 (rank : 13)
Query Neighborhood Hits	27	Target Neighborhood Hits	41	Shared Neighborhood Hits	8
SwissProt Accessions	Q02153, Q86WY5	Gene names	GUCY1B3, GUC1B3, GUCSB3, GUCY1B1
Domain Architecture
Description	Guanylate cyclase soluble subunit beta-1 (EC 4.6.1.2) (GCS-beta-1) (Soluble guanylate cyclase small subunit) (GCS-beta-3).

GCYB1_MOUSE
θ value	θ > 10 (rank : 52)	NC score	0.258829 (rank : 12)
Query Neighborhood Hits	27	Target Neighborhood Hits	40	Shared Neighborhood Hits	8
SwissProt Accessions	O54865	Gene names	Gucy1b3
Domain Architecture	No domain graphic available
Description	Guanylate cyclase soluble subunit beta-1 (EC 4.6.1.2) (GCS-beta-1) (Soluble guanylate cyclase small subunit).

GCYB2_HUMAN
θ value	θ > 10 (rank : 53)	NC score	0.284352 (rank : 10)
Query Neighborhood Hits	27	Target Neighborhood Hits	61	Shared Neighborhood Hits	8
SwissProt Accessions	O75343, Q9NZ64	Gene names	GUCY1B2
Domain Architecture
Description	Guanylate cyclase soluble subunit beta-2 (EC 4.6.1.2) (GCS-beta-2).

GP156_HUMAN
θ value	θ > 10 (rank : 54)	NC score	0.057407 (rank : 79)
Query Neighborhood Hits	27	Target Neighborhood Hits	84	Shared Neighborhood Hits	7
SwissProt Accessions	Q8NFN8, Q86SN6	Gene names	GPR156, GABABL, PGR28
Domain Architecture	No domain graphic available
Description	Probable G-protein coupled receptor 156 (GABAB-related G-protein coupled receptor) (G-protein coupled receptor PGR28).

GPC6A_HUMAN
θ value	θ > 10 (rank : 55)	NC score	0.082124 (rank : 61)
Query Neighborhood Hits	27	Target Neighborhood Hits	53	Shared Neighborhood Hits	16
SwissProt Accessions	Q5T6X5, Q6JK43, Q6JK44, Q8NGU8, Q8NHZ9, Q8TDT6	Gene names	GPRC6A, GPCR33
Domain Architecture	No domain graphic available
Description	G-protein coupled receptor family C group 6 member A precursor (hGPRC6A) (G-protein coupled receptor 33) (hGPCR33).

GPC6A_MOUSE
θ value	θ > 10 (rank : 56)	NC score	0.081381 (rank : 62)
Query Neighborhood Hits	27	Target Neighborhood Hits	57	Shared Neighborhood Hits	16
SwissProt Accessions	Q8K4Z6, Q5DK51, Q5DK52	Gene names	Gprc6a
Domain Architecture	No domain graphic available
Description	G-protein coupled receptor family C group 6 member A precursor.

GUC2C_HUMAN
θ value	θ > 10 (rank : 57)	NC score	0.217898 (rank : 20)
Query Neighborhood Hits	27	Target Neighborhood Hits	624	Shared Neighborhood Hits	9
SwissProt Accessions	P25092	Gene names	GUCY2C, GUC2C, STAR
Domain Architecture
Description	Heat-stable enterotoxin receptor precursor (GC-C) (Intestinal guanylate cyclase) (EC 4.6.1.2) (STA receptor) (hSTAR).

ILK1_HUMAN
θ value	θ > 10 (rank : 58)	NC score	0.066408 (rank : 73)
Query Neighborhood Hits	27	Target Neighborhood Hits	857	Shared Neighborhood Hits	8
SwissProt Accessions	Q13418	Gene names	ILK, ILK1
Domain Architecture
Description	Integrin-linked protein kinase 1 (EC 2.7.11.1) (ILK-1) (59 kDa serine/threonine-protein kinase) (p59ILK).

ILK_MOUSE
θ value	θ > 10 (rank : 59)	NC score	0.066050 (rank : 74)
Query Neighborhood Hits	27	Target Neighborhood Hits	858	Shared Neighborhood Hits	8
SwissProt Accessions	O55222	Gene names	Ilk
Domain Architecture
Description	Integrin-linked protein kinase (EC 2.7.11.1).

IRAK1_HUMAN
θ value	θ > 10 (rank : 60)	NC score	0.053302 (rank : 89)
Query Neighborhood Hits	27	Target Neighborhood Hits	820	Shared Neighborhood Hits	8
SwissProt Accessions	P51617, Q7Z5V4, Q96RL2	Gene names	IRAK1, IRAK
Domain Architecture
Description	Interleukin-1 receptor-associated kinase 1 (EC 2.7.11.1) (IRAK-1).

IRAK1_MOUSE
θ value	θ > 10 (rank : 61)	NC score	0.053370 (rank : 88)
Query Neighborhood Hits	27	Target Neighborhood Hits	784	Shared Neighborhood Hits	8
SwissProt Accessions	Q62406, Q6Y3Z5, Q6Y3Z6	Gene names	Irak1, Il1rak
Domain Architecture
Description	Interleukin-1 receptor-associated kinase 1 (EC 2.7.11.1) (IRAK-1) (IRAK) (Pelle-like protein kinase) (mPLK).

IRAK3_HUMAN
θ value	θ > 10 (rank : 62)	NC score	0.075976 (rank : 65)
Query Neighborhood Hits	27	Target Neighborhood Hits	644	Shared Neighborhood Hits	8
SwissProt Accessions	Q9Y616	Gene names	IRAK3
Domain Architecture	No domain graphic available
Description	Interleukin-1 receptor-associated kinase 3 (EC 2.7.11.1) (IRAK-3) (IL- 1 receptor-associated kinase M) (IRAK-M).

IRAK3_MOUSE
θ value	θ > 10 (rank : 63)	NC score	0.073688 (rank : 69)
Query Neighborhood Hits	27	Target Neighborhood Hits	628	Shared Neighborhood Hits	8
SwissProt Accessions	Q8K4B2, Q8C7U8, Q8CE40, Q8K1S8	Gene names	Irak3
Domain Architecture	No domain graphic available
Description	Interleukin-1 receptor-associated kinase 3 (EC 2.7.11.1) (IRAK-3) (IL- 1 receptor-associated kinase M) (IRAK-M).

IRAK4_HUMAN
θ value	θ > 10 (rank : 64)	NC score	0.053473 (rank : 87)
Query Neighborhood Hits	27	Target Neighborhood Hits	816	Shared Neighborhood Hits	8
SwissProt Accessions	Q9NWZ3, Q8TDF7, Q9Y589	Gene names	IRAK4
Domain Architecture	No domain graphic available
Description	Interleukin-1 receptor-associated kinase 4 (EC 2.7.11.1) (IRAK-4) (NY- REN-64 antigen).

IRAK4_MOUSE
θ value	θ > 10 (rank : 65)	NC score	0.053489 (rank : 86)
Query Neighborhood Hits	27	Target Neighborhood Hits	820	Shared Neighborhood Hits	8
SwissProt Accessions	Q8R4K2, Q80WW1	Gene names	Irak4
Domain Architecture	No domain graphic available
Description	Interleukin-1 receptor-associated kinase 4 (EC 2.7.11.1) (IRAK-4).

KSR1_HUMAN
θ value	θ > 10 (rank : 66)	NC score	0.074918 (rank : 67)
Query Neighborhood Hits	27	Target Neighborhood Hits	867	Shared Neighborhood Hits	8
SwissProt Accessions	Q8IVT5, Q13476	Gene names	KSR1, KSR
Domain Architecture	No domain graphic available
Description	Kinase suppressor of ras-1 (Kinase suppressor of ras).

KSR1_MOUSE
θ value	θ > 10 (rank : 67)	NC score	0.074854 (rank : 68)
Query Neighborhood Hits	27	Target Neighborhood Hits	870	Shared Neighborhood Hits	8
SwissProt Accessions	Q61097, Q61648, Q78DX8	Gene names	Ksr1, Ksr
Domain Architecture	No domain graphic available
Description	Kinase suppressor of ras-1 (Kinase suppressor of ras) (mKSR1) (Hb protein).

KSR2_HUMAN
θ value	θ > 10 (rank : 68)	NC score	0.067970 (rank : 72)
Query Neighborhood Hits	27	Target Neighborhood Hits	920	Shared Neighborhood Hits	8
SwissProt Accessions	Q6VAB6, Q8N775	Gene names	KSR2
Domain Architecture	No domain graphic available
Description	Kinase suppressor of ras-2 (hKSR2).

MGR2_HUMAN
θ value	θ > 10 (rank : 69)	NC score	0.098873 (rank : 52)
Query Neighborhood Hits	27	Target Neighborhood Hits	56	Shared Neighborhood Hits	18
SwissProt Accessions	Q14416, Q52MC6, Q9H3N6	Gene names	GRM2, GPRC1B, MGLUR2
Domain Architecture
Description	Metabotropic glutamate receptor 2 precursor (mGluR2).

MGR3_HUMAN
θ value	θ > 10 (rank : 70)	NC score	0.102685 (rank : 48)
Query Neighborhood Hits	27	Target Neighborhood Hits	58	Shared Neighborhood Hits	19
SwissProt Accessions	Q14832, Q75MV4, Q75N17, Q86YG6, Q8TBH9	Gene names	GRM3, GPRC1C, MGLUR3
Domain Architecture
Description	Metabotropic glutamate receptor 3 precursor (mGluR3).

MGR3_MOUSE
θ value	θ > 10 (rank : 71)	NC score	0.105970 (rank : 47)
Query Neighborhood Hits	27	Target Neighborhood Hits	54	Shared Neighborhood Hits	20
SwissProt Accessions	Q9QYS2	Gene names	Grm3, Gprc1c, Mglur3
Domain Architecture
Description	Metabotropic glutamate receptor 3 precursor (mGluR3).

MGR7_HUMAN
θ value	θ > 10 (rank : 72)	NC score	0.099699 (rank : 51)
Query Neighborhood Hits	27	Target Neighborhood Hits	52	Shared Neighborhood Hits	16
SwissProt Accessions	Q14831, Q8NFS2, Q8NFS3, Q8NFS4	Gene names	GRM7, GPRC1G, MGLUR7
Domain Architecture
Description	Metabotropic glutamate receptor 7 precursor (mGluR7).

MGR7_MOUSE
θ value	θ > 10 (rank : 73)	NC score	0.099753 (rank : 50)
Query Neighborhood Hits	27	Target Neighborhood Hits	53	Shared Neighborhood Hits	16
SwissProt Accessions	Q68ED2	Gene names	Grm7, Gprc1g, Mglur7
Domain Architecture	No domain graphic available
Description	Metabotropic glutamate receptor 7 precursor (mGluR7).

MLKL_HUMAN
θ value	θ > 10 (rank : 74)	NC score	0.077311 (rank : 63)
Query Neighborhood Hits	27	Target Neighborhood Hits	600	Shared Neighborhood Hits	8
SwissProt Accessions	Q8NB16, Q8N6V0	Gene names	MLKL
Domain Architecture	No domain graphic available
Description	Mixed lineage kinase domain-like protein.

MLKL_MOUSE
θ value	θ > 10 (rank : 75)	NC score	0.076139 (rank : 64)
Query Neighborhood Hits	27	Target Neighborhood Hits	707	Shared Neighborhood Hits	8
SwissProt Accessions	Q9D2Y4, Q8CIJ5	Gene names	Mlkl
Domain Architecture	No domain graphic available
Description	Mixed lineage kinase domain-like protein.

MLTK_HUMAN
θ value	θ > 10 (rank : 76)	NC score	0.054848 (rank : 82)
Query Neighborhood Hits	27	Target Neighborhood Hits	911	Shared Neighborhood Hits	8
SwissProt Accessions	Q9NYL2, Q53SX1, Q580W8, Q59GY5, Q86YW8, Q9HCC4, Q9HCC5, Q9HDD2, Q9NYE9	Gene names	MLTK, ZAK
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase MLT (EC 2.7.11.25) (MLK-like mitogen-activated protein triple kinase) (Leucine zipper- and sterile alpha motif-containing kinase) (Sterile alpha motif- and leucine zipper-containing kinase AZK) (Mixed lineage kinase-related kinase) (MLK-related kinase) (MRK) (Cervical cancer suppressor gene 4 protein).

MLTK_MOUSE
θ value	θ > 10 (rank : 77)	NC score	0.054980 (rank : 81)
Query Neighborhood Hits	27	Target Neighborhood Hits	874	Shared Neighborhood Hits	8
SwissProt Accessions	Q9ESL4, Q3V1X8, Q8BR73, Q9ESL3	Gene names	Mltk
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase MLT (EC 2.7.11.25) (MLK-like mitogen-activated protein triple kinase) (Leucine zipper- and sterile alpha motif kinase ZAK) (Sterile alpha motif- and leucine zipper-containing kinase AZK) (Mixed lineage kinase-related kinase) (MLK-related kinase) (MRK).

MOS_HUMAN
θ value	θ > 10 (rank : 78)	NC score	0.050589 (rank : 92)
Query Neighborhood Hits	27	Target Neighborhood Hits	829	Shared Neighborhood Hits	8
SwissProt Accessions	P00540	Gene names	MOS
Domain Architecture
Description	Proto-oncogene serine/threonine-protein kinase mos (EC 2.7.11.1) (c- mos) (Oocyte maturation factor mos).

RIPK1_HUMAN
θ value	θ > 10 (rank : 79)	NC score	0.058528 (rank : 77)
Query Neighborhood Hits	27	Target Neighborhood Hits	891	Shared Neighborhood Hits	8
SwissProt Accessions	Q13546, Q13180	Gene names	RIPK1, RIP
Domain Architecture
Description	Receptor-interacting serine/threonine-protein kinase 1 (EC 2.7.11.1) (Serine/threonine-protein kinase RIP) (Cell death protein RIP) (Receptor-interacting protein).

RIPK1_MOUSE
θ value	θ > 10 (rank : 80)	NC score	0.061657 (rank : 75)
Query Neighborhood Hits	27	Target Neighborhood Hits	874	Shared Neighborhood Hits	8
SwissProt Accessions	Q60855, Q3U0J3, Q8CD90	Gene names	Ripk1, Rinp, Rip
Domain Architecture
Description	Receptor-interacting serine/threonine-protein kinase 1 (EC 2.7.11.1) (Serine/threonine-protein kinase RIP) (Cell death protein RIP) (Receptor-interacting protein).

RIPK2_HUMAN
θ value	θ > 10 (rank : 81)	NC score	0.075690 (rank : 66)
Query Neighborhood Hits	27	Target Neighborhood Hits	774	Shared Neighborhood Hits	8
SwissProt Accessions	O43353, Q6UWF0	Gene names	RIPK2, CARDIAK, RICK, RIP2
Domain Architecture
Description	Receptor-interacting serine/threonine-protein kinase 2 (EC 2.7.11.1) (RIP-like-interacting CLARP kinase) (Receptor-interacting protein 2) (RIP-2) (CARD-containing interleukin-1 beta-converting enzyme- associated kinase) (CARD-containing IL-1 beta ICE-kinase).

RIPK2_MOUSE
θ value	θ > 10 (rank : 82)	NC score	0.073112 (rank : 70)
Query Neighborhood Hits	27	Target Neighborhood Hits	776	Shared Neighborhood Hits	8
SwissProt Accessions	P58801	Gene names	Ripk2
Domain Architecture
Description	Receptor-interacting serine/threonine-protein kinase 2 (EC 2.7.11.1).

RIPK3_HUMAN
θ value	θ > 10 (rank : 83)	NC score	0.058403 (rank : 78)
Query Neighborhood Hits	27	Target Neighborhood Hits	828	Shared Neighborhood Hits	8
SwissProt Accessions	Q9Y572	Gene names	RIPK3, RIP3
Domain Architecture
Description	Receptor-interacting serine/threonine-protein kinase 3 (EC 2.7.11.1) (RIP-like protein kinase 3) (Receptor-interacting protein 3) (RIP-3).

RIPK3_MOUSE
θ value	θ > 10 (rank : 84)	NC score	0.059300 (rank : 76)
Query Neighborhood Hits	27	Target Neighborhood Hits	867	Shared Neighborhood Hits	8
SwissProt Accessions	Q9QZL0	Gene names	Ripk3, Rip3
Domain Architecture
Description	Receptor-interacting serine/threonine-protein kinase 3 (EC 2.7.11.1) (RIP-like protein kinase 3) (Receptor-interacting protein 3) (RIP-3) (mRIP3).

RIPK4_HUMAN
θ value	θ > 10 (rank : 85)	NC score	0.054323 (rank : 85)
Query Neighborhood Hits	27	Target Neighborhood Hits	1094	Shared Neighborhood Hits	8
SwissProt Accessions	P57078, Q96KH0	Gene names	RIPK4, ANKRD3, DIK
Domain Architecture
Description	Receptor-interacting serine/threonine-protein kinase 4 (EC 2.7.11.1) (Ankyrin repeat domain protein 3) (PKC-delta-interacting protein kinase).

TESK2_HUMAN
θ value	θ > 10 (rank : 86)	NC score	0.051443 (rank : 90)
Query Neighborhood Hits	27	Target Neighborhood Hits	851	Shared Neighborhood Hits	8
SwissProt Accessions	Q96S53, Q8N520, Q9Y3Q6	Gene names	TESK2
Domain Architecture
Description	Dual specificity testis-specific protein kinase 2 (EC 2.7.12.1) (Testicular protein kinase 2).

TESK2_MOUSE
θ value	θ > 10 (rank : 87)	NC score	0.051024 (rank : 91)
Query Neighborhood Hits	27	Target Neighborhood Hits	833	Shared Neighborhood Hits	8
SwissProt Accessions	Q8VCT9	Gene names	Tesk2
Domain Architecture
Description	Dual specificity testis-specific protein kinase 2 (EC 2.7.12.1) (Testicular protein kinase 2).

TOPK_HUMAN
θ value	θ > 10 (rank : 88)	NC score	0.055335 (rank : 80)
Query Neighborhood Hits	27	Target Neighborhood Hits	605	Shared Neighborhood Hits	8
SwissProt Accessions	Q96KB5, Q9NPD9, Q9NYL7, Q9NZK6	Gene names	PBK, TOPK
Domain Architecture	No domain graphic available
Description	T-lymphokine-activated killer cell-originated protein kinase (EC 2.7.12.2) (T-LAK cell-originated protein kinase) (PDZ-binding kinase) (Spermatogenesis-related protein kinase) (SPK) (MAPKK-like protein kinase) (Nori-3).

TOPK_MOUSE
θ value	θ > 10 (rank : 89)	NC score	0.054414 (rank : 84)
Query Neighborhood Hits	27	Target Neighborhood Hits	618	Shared Neighborhood Hits	8
SwissProt Accessions	Q9JJ78, Q922V2, Q9D184	Gene names	Pbk, Topk
Domain Architecture	No domain graphic available
Description	T-lymphokine-activated killer cell-originated protein kinase (EC 2.7.12.2) (T-LAK cell-originated protein kinase) (PDZ-binding kinase).

TS1R1_MOUSE
θ value	θ > 10 (rank : 90)	NC score	0.086971 (rank : 58)
Query Neighborhood Hits	27	Target Neighborhood Hits	57	Shared Neighborhood Hits	18
SwissProt Accessions	Q99PG6, Q6NS58, Q923J9, Q925I5, Q99PG5	Gene names	Tas1r1, Gpr70, T1r1, Tr1
Domain Architecture	No domain graphic available
Description	Taste receptor type 1 member 1 precursor (G-protein coupled receptor 70).

TS1R2_HUMAN
θ value	θ > 10 (rank : 91)	NC score	0.093291 (rank : 53)
Query Neighborhood Hits	27	Target Neighborhood Hits	48	Shared Neighborhood Hits	19
SwissProt Accessions	Q8TE23, Q5TZ19	Gene names	TAS1R2, GPR71, T1R2, TR2
Domain Architecture	No domain graphic available
Description	Taste receptor type 1 member 2 precursor (G-protein coupled receptor 71) (Sweet taste receptor T1R2).

TS1R3_HUMAN
θ value	θ > 10 (rank : 92)	NC score	0.085439 (rank : 60)
Query Neighborhood Hits	27	Target Neighborhood Hits	46	Shared Neighborhood Hits	16
SwissProt Accessions	Q7RTX0, Q5TA49, Q8NGW9	Gene names	TAS1R3, T1R3, TR3
Domain Architecture	No domain graphic available
Description	Taste receptor type 1 member 3 precursor (Sweet taste receptor T1R3).

TS1R3_MOUSE
θ value	θ > 10 (rank : 93)	NC score	0.101571 (rank : 49)
Query Neighborhood Hits	27	Target Neighborhood Hits	49	Shared Neighborhood Hits	22
SwissProt Accessions	Q925D8, Q91VA4, Q923K0, Q925A4, Q925D9	Gene names	Tas1r3, Sac, T1r3, Tr3
Domain Architecture	No domain graphic available
Description	Taste receptor type 1 member 3 precursor (Sweet taste receptor T1R3) (Saccharin preference protein).

V2R1B_MOUSE
θ value	θ > 10 (rank : 94)	NC score	0.071156 (rank : 71)
Query Neighborhood Hits	27	Target Neighborhood Hits	39	Shared Neighborhood Hits	11
SwissProt Accessions	Q6TAC4, O70409	Gene names	V2r1b
Domain Architecture	No domain graphic available
Description	Vomeronasal type-2 receptor 1b precursor (Putative pheromone receptor V2R1b).

V2RX_MOUSE
θ value	θ > 10 (rank : 95)	NC score	0.089506 (rank : 56)
Query Neighborhood Hits	27	Target Neighborhood Hits	45	Shared Neighborhood Hits	16
SwissProt Accessions	O70410	Gene names
Domain Architecture	No domain graphic available
Description	Vomeronasal type-2 receptor X precursor (Putative pheromone receptor V2RX).

Hits sorted by NC score

ANPRC_MOUSE
NC score	0.999962 (rank : 1)	θ value	0 (rank : 2)
Query Neighborhood Hits	27	Target Neighborhood Hits	27	Shared Neighborhood Hits	27
SwissProt Accessions	P70180, P97804, Q9R025, Q9R027, Q9R028	Gene names	Npr3
Domain Architecture
Description	Atrial natriuretic peptide clearance receptor precursor (ANP-C) (ANPRC) (NPR-C) (Atrial natriuretic peptide C-type receptor) (EF-2).

ANPRC_HUMAN
NC score	0.996091 (rank : 2)	θ value	0 (rank : 1)
Query Neighborhood Hits	27	Target Neighborhood Hits	27	Shared Neighborhood Hits	22
SwissProt Accessions	P17342	Gene names	NPR3, ANPRC
Domain Architecture
Description	Atrial natriuretic peptide clearance receptor precursor (ANP-C) (ANPRC) (NPR-C) (Atrial natriuretic peptide C-type receptor).

ANPRB_MOUSE
NC score	0.386577 (rank : 3)	θ value	2.3352e-48 (rank : 5)
Query Neighborhood Hits	27	Target Neighborhood Hits	607	Shared Neighborhood Hits	14
SwissProt Accessions	Q6VVW5, Q6VVW3, Q6VVW4, Q8CGA9	Gene names	Npr2
Domain Architecture	No domain graphic available
Description	Atrial natriuretic peptide receptor B precursor (ANP-B) (ANPRB) (GC-B) (Guanylate cyclase B) (EC 4.6.1.2) (NPR-B) (Atrial natriuretic peptide B-type receptor).

ANPRA_HUMAN
NC score	0.380231 (rank : 4)	θ value	4.85792e-54 (rank : 4)
Query Neighborhood Hits	27	Target Neighborhood Hits	612	Shared Neighborhood Hits	16
SwissProt Accessions	P16066, Q6P4Q3	Gene names	NPR1, ANPRA
Domain Architecture
Description	Atrial natriuretic peptide receptor A precursor (ANP-A) (ANPRA) (GC-A) (Guanylate cyclase) (EC 4.6.1.2) (NPR-A) (Atrial natriuretic peptide A-type receptor).

ANPRA_MOUSE
NC score	0.379782 (rank : 5)	θ value	7.49467e-55 (rank : 3)
Query Neighborhood Hits	27	Target Neighborhood Hits	600	Shared Neighborhood Hits	14
SwissProt Accessions	P18293	Gene names	Npr1, Npra
Domain Architecture
Description	Atrial natriuretic peptide receptor A precursor (ANP-A) (ANPRA) (GC-A) (Guanylate cyclase) (EC 4.6.1.2) (NPR-A) (Atrial natriuretic peptide A-type receptor).

ANPRB_HUMAN
NC score	0.372398 (rank : 6)	θ value	6.7944e-48 (rank : 6)
Query Neighborhood Hits	27	Target Neighborhood Hits	646	Shared Neighborhood Hits	14
SwissProt Accessions	P20594, O60871, Q9UQ50	Gene names	NPR2, ANPRB
Domain Architecture
Description	Atrial natriuretic peptide receptor B precursor (ANP-B) (ANPRB) (GC-B) (Guanylate cyclase B) (EC 4.6.1.2) (NPR-B) (Atrial natriuretic peptide B-type receptor).

GABR1_MOUSE
NC score	0.349740 (rank : 7)	θ value	6.43352e-06 (rank : 11)
Query Neighborhood Hits	27	Target Neighborhood Hits	139	Shared Neighborhood Hits	21
SwissProt Accessions	Q9WV18, Q9WU48, Q9WV15, Q9WV16, Q9WV17	Gene names	Gabbr1
Domain Architecture
Description	Gamma-aminobutyric acid type B receptor, subunit 1 precursor (GABA-B receptor 1) (GABA-B-R1) (Gb1).

GABR1_HUMAN
NC score	0.343154 (rank : 8)	θ value	1.09739e-05 (rank : 12)
Query Neighborhood Hits	27	Target Neighborhood Hits	142	Shared Neighborhood Hits	21
SwissProt Accessions	Q9UBS5, O95375, O95468, O95975, O96022, Q86W60, Q9UQQ0	Gene names	GABBR1, GPRC3A
Domain Architecture
Description	Gamma-aminobutyric acid type B receptor, subunit 1 precursor (GABA-B receptor 1) (GABA-B-R1) (Gb1).

GUC2G_MOUSE
NC score	0.309747 (rank : 9)	θ value	1.99529e-15 (rank : 7)
Query Neighborhood Hits	27	Target Neighborhood Hits	644	Shared Neighborhood Hits	23
SwissProt Accessions	Q6TL19, Q8BWU7	Gene names	Gucy2g
Domain Architecture	No domain graphic available
Description	Guanylate cyclase 2G precursor (EC 4.6.1.2) (Guanylyl cyclase receptor G) (mGC-G).

GCYB2_HUMAN
NC score	0.284352 (rank : 10)	θ value	θ > 10 (rank : 53)
Query Neighborhood Hits	27	Target Neighborhood Hits	61	Shared Neighborhood Hits	8
SwissProt Accessions	O75343, Q9NZ64	Gene names	GUCY1B2
Domain Architecture
Description	Guanylate cyclase soluble subunit beta-2 (EC 4.6.1.2) (GCS-beta-2).

GCYA2_HUMAN
NC score	0.260992 (rank : 11)	θ value	θ > 10 (rank : 48)
Query Neighborhood Hits	27	Target Neighborhood Hits	50	Shared Neighborhood Hits	8
SwissProt Accessions	P33402	Gene names	GUCY1A2, GUC1A2, GUCSA2
Domain Architecture
Description	Guanylate cyclase soluble subunit alpha-2 (EC 4.6.1.2) (GCS-alpha-2).

GCYB1_MOUSE
NC score	0.258829 (rank : 12)	θ value	θ > 10 (rank : 52)
Query Neighborhood Hits	27	Target Neighborhood Hits	40	Shared Neighborhood Hits	8
SwissProt Accessions	O54865	Gene names	Gucy1b3
Domain Architecture	No domain graphic available
Description	Guanylate cyclase soluble subunit beta-1 (EC 4.6.1.2) (GCS-beta-1) (Soluble guanylate cyclase small subunit).

GCYB1_HUMAN
NC score	0.258534 (rank : 13)	θ value	θ > 10 (rank : 51)
Query Neighborhood Hits	27	Target Neighborhood Hits	41	Shared Neighborhood Hits	8
SwissProt Accessions	Q02153, Q86WY5	Gene names	GUCY1B3, GUC1B3, GUCSB3, GUCY1B1
Domain Architecture
Description	Guanylate cyclase soluble subunit beta-1 (EC 4.6.1.2) (GCS-beta-1) (Soluble guanylate cyclase small subunit) (GCS-beta-3).

GCYA3_MOUSE
NC score	0.254607 (rank : 14)	θ value	θ > 10 (rank : 50)
Query Neighborhood Hits	27	Target Neighborhood Hits	41	Shared Neighborhood Hits	8
SwissProt Accessions	Q9ERL9, Q9DBQ3	Gene names	Gucy1a3, Gucy1a1
Domain Architecture
Description	Guanylate cyclase soluble subunit alpha-3 (EC 4.6.1.2) (GCS-alpha-3) (Soluble guanylate cyclase large subunit) (GCS-alpha-1).

GCYA3_HUMAN
NC score	0.254069 (rank : 15)	θ value	θ > 10 (rank : 49)
Query Neighborhood Hits	27	Target Neighborhood Hits	36	Shared Neighborhood Hits	8
SwissProt Accessions	Q02108, O43843, Q8TAH3	Gene names	GUCY1A3, GUC1A3, GUCSA3, GUCY1A1
Domain Architecture
Description	Guanylate cyclase soluble subunit alpha-3 (EC 4.6.1.2) (GCS-alpha-3) (Soluble guanylate cyclase large subunit) (GCS-alpha-1).

GUC2D_HUMAN
NC score	0.250806 (rank : 16)	θ value	0.125558 (rank : 18)
Query Neighborhood Hits	27	Target Neighborhood Hits	715	Shared Neighborhood Hits	10
SwissProt Accessions	Q02846, Q6LEA7	Gene names	GUCY2D, CORD6, GUC1A4, GUC2D, RETGC, RETGC1
Domain Architecture
Description	Retinal guanylyl cyclase 1 precursor (EC 4.6.1.2) (Guanylate cyclase 2D, retinal) (RETGC-1) (Rod outer segment membrane guanylate cyclase) (ROS-GC).

GABR2_HUMAN
NC score	0.247306 (rank : 17)	θ value	3.19293e-05 (rank : 13)
Query Neighborhood Hits	27	Target Neighborhood Hits	101	Shared Neighborhood Hits	20
SwissProt Accessions	O75899, O75974, O75975, Q5VXZ2, Q8WX04, Q9P1R2, Q9UNR1, Q9UNS9	Gene names	GABBR2, GPR51, GPRC3B
Domain Architecture
Description	Gamma-aminobutyric acid type B receptor, subunit 2 precursor (GABA-B receptor 2) (GABA-B-R2) (Gb2) (GABABR2) (G-protein coupled receptor 51) (HG20).

GUC2F_HUMAN
NC score	0.244596 (rank : 18)	θ value	7.59969e-07 (rank : 8)
Query Neighborhood Hits	27	Target Neighborhood Hits	740	Shared Neighborhood Hits	15
SwissProt Accessions	P51841, Q9UJF1	Gene names	GUCY2F, GUC2F, RETGC2
Domain Architecture
Description	Retinal guanylyl cyclase 2 precursor (EC 4.6.1.2) (Guanylate cyclase 2F, retinal) (RETGC-2) (Rod outer segment membrane guanylate cyclase 2) (ROS-GC2) (Guanylate cyclase F) (GC-F).

GUC2E_MOUSE
NC score	0.241782 (rank : 19)	θ value	4.03905 (rank : 24)
Query Neighborhood Hits	27	Target Neighborhood Hits	692	Shared Neighborhood Hits	9
SwissProt Accessions	P52785	Gene names	Gucy2e, Guc2e
Domain Architecture
Description	Guanylyl cyclase GC-E precursor (EC 4.6.1.2) (Guanylate cyclase 2E).

GUC2C_HUMAN
NC score	0.217898 (rank : 20)	θ value	θ > 10 (rank : 57)
Query Neighborhood Hits	27	Target Neighborhood Hits	624	Shared Neighborhood Hits	9
SwissProt Accessions	P25092	Gene names	GUCY2C, GUC2C, STAR
Domain Architecture
Description	Heat-stable enterotoxin receptor precursor (GC-C) (Intestinal guanylate cyclase) (EC 4.6.1.2) (STA receptor) (hSTAR).

ADCY9_HUMAN
NC score	0.179721 (rank : 21)	θ value	θ > 10 (rank : 42)
Query Neighborhood Hits	27	Target Neighborhood Hits	51	Shared Neighborhood Hits	8
SwissProt Accessions	O60503, O60273, Q4ZHT9, Q4ZIR5, Q9BWT4, Q9UGP2	Gene names	ADCY9, KIAA0520
Domain Architecture
Description	Adenylate cyclase type 9 (EC 4.6.1.1) (Adenylate cyclase type IX) (ATP pyrophosphate-lyase 9) (Adenylyl cyclase 9).

ADCY9_MOUSE
NC score	0.179237 (rank : 22)	θ value	θ > 10 (rank : 43)
Query Neighborhood Hits	27	Target Neighborhood Hits	46	Shared Neighborhood Hits	8
SwissProt Accessions	P51830, Q61279	Gene names	Adcy9
Domain Architecture
Description	Adenylate cyclase type 9 (EC 4.6.1.1) (Adenylate cyclase type IX) (ATP pyrophosphate-lyase 9) (Adenylyl cyclase 9) (Adenylyl cyclase type 10) (ACTP10).

ADCY3_MOUSE
NC score	0.162850 (rank : 23)	θ value	θ > 10 (rank : 33)
Query Neighborhood Hits	27	Target Neighborhood Hits	47	Shared Neighborhood Hits	8
SwissProt Accessions	Q8VHH7	Gene names	Adcy3
Domain Architecture
Description	Adenylate cyclase type 3 (EC 4.6.1.1) (Adenylate cyclase type III) (Adenylate cyclase, olfactive type) (ATP pyrophosphate-lyase 3) (Adenylyl cyclase 3) (AC-III) (AC3).

ADCY3_HUMAN
NC score	0.160455 (rank : 24)	θ value	θ > 10 (rank : 32)
Query Neighborhood Hits	27	Target Neighborhood Hits	58	Shared Neighborhood Hits	8
SwissProt Accessions	O60266, Q9UDB1	Gene names	ADCY3, KIAA0511
Domain Architecture
Description	Adenylate cyclase type 3 (EC 4.6.1.1) (Adenylate cyclase type III) (Adenylate cyclase, olfactive type) (ATP pyrophosphate-lyase 3) (Adenylyl cyclase 3) (AC-III) (AC3).

MGR1_MOUSE
NC score	0.157327 (rank : 25)	θ value	2.21117e-06 (rank : 9)
Query Neighborhood Hits	27	Target Neighborhood Hits	90	Shared Neighborhood Hits	20
SwissProt Accessions	P97772, Q6AXG4, Q9EPV6	Gene names	Grm1, Gprc1a, Mglur1
Domain Architecture
Description	Metabotropic glutamate receptor 1 precursor (mGluR1).

MGR1_HUMAN
NC score	0.155895 (rank : 26)	θ value	3.77169e-06 (rank : 10)
Query Neighborhood Hits	27	Target Neighborhood Hits	85	Shared Neighborhood Hits	20
SwissProt Accessions	Q13255, Q13256, Q14757, Q14758, Q5VTF7, Q5VTF8, Q9NU10, Q9UGS9, Q9UGT0	Gene names	GRM1, GPRC1A, MGLUR1
Domain Architecture
Description	Metabotropic glutamate receptor 1 precursor (mGluR1).

ADCY8_HUMAN
NC score	0.154504 (rank : 27)	θ value	θ > 10 (rank : 40)
Query Neighborhood Hits	27	Target Neighborhood Hits	41	Shared Neighborhood Hits	8
SwissProt Accessions	P40145	Gene names	ADCY8
Domain Architecture
Description	Adenylate cyclase type 8 (EC 4.6.1.1) (Adenylate cyclase type VIII) (ATP pyrophosphate-lyase 8) (Ca(2+)/calmodulin-activated adenylyl cyclase).

ADCY8_MOUSE
NC score	0.154500 (rank : 28)	θ value	θ > 10 (rank : 41)
Query Neighborhood Hits	27	Target Neighborhood Hits	42	Shared Neighborhood Hits	8
SwissProt Accessions	P97490	Gene names	Adcy8
Domain Architecture
Description	Adenylate cyclase type 8 (EC 4.6.1.1) (Adenylate cyclase type VIII) (ATP pyrophosphate-lyase 8) (Ca(2+)/calmodulin-activated adenylyl cyclase).

ADCY1_HUMAN
NC score	0.154128 (rank : 29)	θ value	θ > 10 (rank : 28)
Query Neighborhood Hits	27	Target Neighborhood Hits	42	Shared Neighborhood Hits	8
SwissProt Accessions	Q08828, Q75MI1	Gene names	ADCY1
Domain Architecture	No domain graphic available
Description	Adenylate cyclase type 1 (EC 4.6.1.1) (Adenylate cyclase type I) (ATP pyrophosphate-lyase 1) (Ca(2+)/calmodulin-activated adenylyl cyclase).

ADCY6_MOUSE
NC score	0.154065 (rank : 30)	θ value	θ > 10 (rank : 37)
Query Neighborhood Hits	27	Target Neighborhood Hits	57	Shared Neighborhood Hits	8
SwissProt Accessions	Q01341	Gene names	Adcy6
Domain Architecture
Description	Adenylate cyclase type 6 (EC 4.6.1.1) (Adenylate cyclase type VI) (ATP pyrophosphate-lyase 6) (Ca(2+)-inhibitable adenylyl cyclase).

ADCY6_HUMAN
NC score	0.153913 (rank : 31)	θ value	θ > 10 (rank : 36)
Query Neighborhood Hits	27	Target Neighborhood Hits	52	Shared Neighborhood Hits	8
SwissProt Accessions	O43306, Q9NR75	Gene names	ADCY6, KIAA0422
Domain Architecture
Description	Adenylate cyclase type 6 (EC 4.6.1.1) (Adenylate cyclase type VI) (ATP pyrophosphate-lyase 6) (Ca(2+)-inhibitable adenylyl cyclase).

ADCY1_MOUSE
NC score	0.152746 (rank : 32)	θ value	θ > 10 (rank : 29)
Query Neighborhood Hits	27	Target Neighborhood Hits	40	Shared Neighborhood Hits	8
SwissProt Accessions	O88444, Q5SS89	Gene names	Adcy1
Domain Architecture	No domain graphic available
Description	Adenylate cyclase type 1 (EC 4.6.1.1) (Adenylate cyclase type I) (ATP pyrophosphate-lyase 1) (Ca(2+)/calmodulin-activated adenylyl cyclase).

ADCY4_MOUSE
NC score	0.151798 (rank : 33)	θ value	θ > 10 (rank : 35)
Query Neighborhood Hits	27	Target Neighborhood Hits	40	Shared Neighborhood Hits	8
SwissProt Accessions	Q91WF3	Gene names	Adcy4
Domain Architecture
Description	Adenylate cyclase type 4 (EC 4.6.1.1) (Adenylate cyclase type IV) (ATP pyrophosphate-lyase 4) (Adenylyl cyclase 4).

ADCY7_MOUSE
NC score	0.150685 (rank : 34)	θ value	θ > 10 (rank : 39)
Query Neighborhood Hits	27	Target Neighborhood Hits	37	Shared Neighborhood Hits	8
SwissProt Accessions	P51829	Gene names	Adcy7
Domain Architecture
Description	Adenylate cyclase type 7 (EC 4.6.1.1) (Adenylate cyclase type VII) (ATP pyrophosphate-lyase 7) (Adenylyl cyclase 7).

ADCY7_HUMAN
NC score	0.150192 (rank : 35)	θ value	θ > 10 (rank : 38)
Query Neighborhood Hits	27	Target Neighborhood Hits	44	Shared Neighborhood Hits	8
SwissProt Accessions	P51828	Gene names	ADCY7, KIAA0037
Domain Architecture	No domain graphic available
Description	Adenylate cyclase type 7 (EC 4.6.1.1) (Adenylate cyclase type VII) (ATP pyrophosphate-lyase 7) (Adenylyl cyclase 7).

ADCY4_HUMAN
NC score	0.149652 (rank : 36)	θ value	θ > 10 (rank : 34)
Query Neighborhood Hits	27	Target Neighborhood Hits	41	Shared Neighborhood Hits	8
SwissProt Accessions	Q8NFM4, Q96ML7	Gene names	ADCY4
Domain Architecture
Description	Adenylate cyclase type 4 (EC 4.6.1.1) (Adenylate cyclase type IV) (ATP pyrophosphate-lyase 4) (Adenylyl cyclase 4).

MGR5_HUMAN
NC score	0.146310 (rank : 37)	θ value	0.000158464 (rank : 14)
Query Neighborhood Hits	27	Target Neighborhood Hits	72	Shared Neighborhood Hits	20
SwissProt Accessions	P41594	Gene names	GRM5, GPRC1E, MGLUR5
Domain Architecture
Description	Metabotropic glutamate receptor 5 precursor (mGluR5).

ADCY2_HUMAN
NC score	0.145947 (rank : 38)	θ value	θ > 10 (rank : 30)
Query Neighborhood Hits	27	Target Neighborhood Hits	38	Shared Neighborhood Hits	8
SwissProt Accessions	Q08462, Q9UPU2	Gene names	ADCY2, KIAA1060
Domain Architecture
Description	Adenylate cyclase type 2 (EC 4.6.1.1) (Adenylate cyclase type II) (ATP pyrophosphate-lyase 2) (Adenylyl cyclase 2).

ADCY2_MOUSE
NC score	0.143895 (rank : 39)	θ value	θ > 10 (rank : 31)
Query Neighborhood Hits	27	Target Neighborhood Hits	38	Shared Neighborhood Hits	8
SwissProt Accessions	Q80TL1, Q8CFU6	Gene names	Adcy2, Kiaa1060
Domain Architecture	No domain graphic available
Description	Adenylate cyclase type 2 (EC 4.6.1.1) (Adenylate cyclase type II) (ATP pyrophosphate-lyase 2) (Adenylyl cyclase 2).

MGR4_HUMAN
NC score	0.123566 (rank : 40)	θ value	0.0736092 (rank : 17)
Query Neighborhood Hits	27	Target Neighborhood Hits	63	Shared Neighborhood Hits	18
SwissProt Accessions	Q14833, Q5SZ84	Gene names	GRM4, GPRC1D, MGLUR4
Domain Architecture
Description	Metabotropic glutamate receptor 4 precursor (mGluR4).

TS1R1_HUMAN
NC score	0.115279 (rank : 41)	θ value	4.03905 (rank : 27)
Query Neighborhood Hits	27	Target Neighborhood Hits	72	Shared Neighborhood Hits	22
SwissProt Accessions	Q7RTX1, Q8NGZ7, Q8TDJ7, Q8TDJ8, Q8TDJ9, Q8TDK0	Gene names	TAS1R1, GPR70, T1R1, TR1
Domain Architecture	No domain graphic available
Description	Taste receptor type 1 member 1 precursor (G-protein coupled receptor 70) (Gm148).

TS1R2_MOUSE
NC score	0.112788 (rank : 42)	θ value	1.38821 (rank : 20)
Query Neighborhood Hits	27	Target Neighborhood Hits	69	Shared Neighborhood Hits	22
SwissProt Accessions	Q925I4, Q923J8	Gene names	Tas1r2, Gpr71, T1r2, Tr2
Domain Architecture	No domain graphic available
Description	Taste receptor type 1 member 2 precursor (G-protein coupled receptor 71) (Sweet taste receptor T1R2).

MGR8_HUMAN
NC score	0.108421 (rank : 43)	θ value	4.03905 (rank : 25)
Query Neighborhood Hits	27	Target Neighborhood Hits	49	Shared Neighborhood Hits	17
SwissProt Accessions	O00222, O15493, O95945, O95946, Q3MIV9, Q52M02, Q6J165	Gene names	GRM8, GPRC1H, MGLUR8
Domain Architecture
Description	Metabotropic glutamate receptor 8 precursor (mGluR8).

MGR8_MOUSE
NC score	0.108274 (rank : 44)	θ value	4.03905 (rank : 26)
Query Neighborhood Hits	27	Target Neighborhood Hits	44	Shared Neighborhood Hits	17
SwissProt Accessions	P47743, Q6B964	Gene names	Grm8, Gprc1h, Mglur8
Domain Architecture
Description	Metabotropic glutamate receptor 8 precursor (mGluR8).

MGR6_MOUSE
NC score	0.107534 (rank : 45)	θ value	2.36792 (rank : 21)
Query Neighborhood Hits	27	Target Neighborhood Hits	56	Shared Neighborhood Hits	17
SwissProt Accessions	Q5NCH9	Gene names	Grm6, Gprc1f, Mglur6
Domain Architecture	No domain graphic available
Description	Metabotropic glutamate receptor 6 precursor (mGluR6).

MGR6_HUMAN
NC score	0.107027 (rank : 46)	θ value	3.0926 (rank : 23)
Query Neighborhood Hits	27	Target Neighborhood Hits	58	Shared Neighborhood Hits	17
SwissProt Accessions	O15303	Gene names	GRM6, GPRC1F, MGLUR6
Domain Architecture
Description	Metabotropic glutamate receptor 6 precursor (mGluR6).

MGR3_MOUSE
NC score	0.105970 (rank : 47)	θ value	θ > 10 (rank : 71)
Query Neighborhood Hits	27	Target Neighborhood Hits	54	Shared Neighborhood Hits	20
SwissProt Accessions	Q9QYS2	Gene names	Grm3, Gprc1c, Mglur3
Domain Architecture
Description	Metabotropic glutamate receptor 3 precursor (mGluR3).

MGR3_HUMAN
NC score	0.102685 (rank : 48)	θ value	θ > 10 (rank : 70)
Query Neighborhood Hits	27	Target Neighborhood Hits	58	Shared Neighborhood Hits	19
SwissProt Accessions	Q14832, Q75MV4, Q75N17, Q86YG6, Q8TBH9	Gene names	GRM3, GPRC1C, MGLUR3
Domain Architecture
Description	Metabotropic glutamate receptor 3 precursor (mGluR3).

TS1R3_MOUSE
NC score	0.101571 (rank : 49)	θ value	θ > 10 (rank : 93)
Query Neighborhood Hits	27	Target Neighborhood Hits	49	Shared Neighborhood Hits	22
SwissProt Accessions	Q925D8, Q91VA4, Q923K0, Q925A4, Q925D9	Gene names	Tas1r3, Sac, T1r3, Tr3
Domain Architecture	No domain graphic available
Description	Taste receptor type 1 member 3 precursor (Sweet taste receptor T1R3) (Saccharin preference protein).

MGR7_MOUSE
NC score	0.099753 (rank : 50)	θ value	θ > 10 (rank : 73)
Query Neighborhood Hits	27	Target Neighborhood Hits	53	Shared Neighborhood Hits	16
SwissProt Accessions	Q68ED2	Gene names	Grm7, Gprc1g, Mglur7
Domain Architecture	No domain graphic available
Description	Metabotropic glutamate receptor 7 precursor (mGluR7).

MGR7_HUMAN
NC score	0.099699 (rank : 51)	θ value	θ > 10 (rank : 72)
Query Neighborhood Hits	27	Target Neighborhood Hits	52	Shared Neighborhood Hits	16
SwissProt Accessions	Q14831, Q8NFS2, Q8NFS3, Q8NFS4	Gene names	GRM7, GPRC1G, MGLUR7
Domain Architecture
Description	Metabotropic glutamate receptor 7 precursor (mGluR7).

MGR2_HUMAN
NC score	0.098873 (rank : 52)	θ value	θ > 10 (rank : 69)
Query Neighborhood Hits	27	Target Neighborhood Hits	56	Shared Neighborhood Hits	18
SwissProt Accessions	Q14416, Q52MC6, Q9H3N6	Gene names	GRM2, GPRC1B, MGLUR2
Domain Architecture
Description	Metabotropic glutamate receptor 2 precursor (mGluR2).

TS1R2_HUMAN
NC score	0.093291 (rank : 53)	θ value	θ > 10 (rank : 91)
Query Neighborhood Hits	27	Target Neighborhood Hits	48	Shared Neighborhood Hits	19
SwissProt Accessions	Q8TE23, Q5TZ19	Gene names	TAS1R2, GPR71, T1R2, TR2
Domain Architecture	No domain graphic available
Description	Taste receptor type 1 member 2 precursor (G-protein coupled receptor 71) (Sweet taste receptor T1R2).

CASR_HUMAN
NC score	0.091967 (rank : 54)	θ value	θ > 10 (rank : 46)
Query Neighborhood Hits	27	Target Neighborhood Hits	71	Shared Neighborhood Hits	18
SwissProt Accessions	P41180, Q13912, Q16108, Q16109, Q16110, Q16379, Q4PJ19	Gene names	CASR, GPRC2A, PCAR1
Domain Architecture
Description	Extracellular calcium-sensing receptor precursor (CaSR) (Parathyroid Cell calcium-sensing receptor).

CASR_MOUSE
NC score	0.091685 (rank : 55)	θ value	θ > 10 (rank : 47)
Query Neighborhood Hits	27	Target Neighborhood Hits	72	Shared Neighborhood Hits	18
SwissProt Accessions	Q9QY96, O08968, O88519, Q9QY95, Q9QZU8, Q9R1D6, Q9R1Y2	Gene names	Casr, Gprc2a
Domain Architecture
Description	Extracellular calcium-sensing receptor precursor (CaSR) (Parathyroid Cell calcium-sensing receptor).

V2RX_MOUSE
NC score	0.089506 (rank : 56)	θ value	θ > 10 (rank : 95)
Query Neighborhood Hits	27	Target Neighborhood Hits	45	Shared Neighborhood Hits	16
SwissProt Accessions	O70410	Gene names
Domain Architecture	No domain graphic available
Description	Vomeronasal type-2 receptor X precursor (Putative pheromone receptor V2RX).

NMDZ1_MOUSE
NC score	0.087017 (rank : 57)	θ value	0.00869519 (rank : 16)
Query Neighborhood Hits	27	Target Neighborhood Hits	76	Shared Neighborhood Hits	19
SwissProt Accessions	P35438, Q8CFS4	Gene names	Grin1, Glurz1
Domain Architecture
Description	Glutamate [NMDA] receptor subunit zeta 1 precursor (N-methyl-D- aspartate receptor subunit NR1).

TS1R1_MOUSE
NC score	0.086971 (rank : 58)	θ value	θ > 10 (rank : 90)
Query Neighborhood Hits	27	Target Neighborhood Hits	57	Shared Neighborhood Hits	18
SwissProt Accessions	Q99PG6, Q6NS58, Q923J9, Q925I5, Q99PG5	Gene names	Tas1r1, Gpr70, T1r1, Tr1
Domain Architecture	No domain graphic available
Description	Taste receptor type 1 member 1 precursor (G-protein coupled receptor 70).

NMDZ1_HUMAN
NC score	0.086693 (rank : 59)	θ value	0.00869519 (rank : 15)
Query Neighborhood Hits	27	Target Neighborhood Hits	77	Shared Neighborhood Hits	20
SwissProt Accessions	Q05586, P35437, Q12867, Q12868	Gene names	GRIN1, NMDAR1
Domain Architecture
Description	Glutamate [NMDA] receptor subunit zeta 1 precursor (N-methyl-D- aspartate receptor subunit NR1).

TS1R3_HUMAN
NC score	0.085439 (rank : 60)	θ value	θ > 10 (rank : 92)
Query Neighborhood Hits	27	Target Neighborhood Hits	46	Shared Neighborhood Hits	16
SwissProt Accessions	Q7RTX0, Q5TA49, Q8NGW9	Gene names	TAS1R3, T1R3, TR3
Domain Architecture	No domain graphic available
Description	Taste receptor type 1 member 3 precursor (Sweet taste receptor T1R3).

GPC6A_HUMAN
NC score	0.082124 (rank : 61)	θ value	θ > 10 (rank : 55)
Query Neighborhood Hits	27	Target Neighborhood Hits	53	Shared Neighborhood Hits	16
SwissProt Accessions	Q5T6X5, Q6JK43, Q6JK44, Q8NGU8, Q8NHZ9, Q8TDT6	Gene names	GPRC6A, GPCR33
Domain Architecture	No domain graphic available
Description	G-protein coupled receptor family C group 6 member A precursor (hGPRC6A) (G-protein coupled receptor 33) (hGPCR33).

GPC6A_MOUSE
NC score	0.081381 (rank : 62)	θ value	θ > 10 (rank : 56)
Query Neighborhood Hits	27	Target Neighborhood Hits	57	Shared Neighborhood Hits	16
SwissProt Accessions	Q8K4Z6, Q5DK51, Q5DK52	Gene names	Gprc6a
Domain Architecture	No domain graphic available
Description	G-protein coupled receptor family C group 6 member A precursor.

MLKL_HUMAN
NC score	0.077311 (rank : 63)	θ value	θ > 10 (rank : 74)
Query Neighborhood Hits	27	Target Neighborhood Hits	600	Shared Neighborhood Hits	8
SwissProt Accessions	Q8NB16, Q8N6V0	Gene names	MLKL
Domain Architecture	No domain graphic available
Description	Mixed lineage kinase domain-like protein.

MLKL_MOUSE
NC score	0.076139 (rank : 64)	θ value	θ > 10 (rank : 75)
Query Neighborhood Hits	27	Target Neighborhood Hits	707	Shared Neighborhood Hits	8
SwissProt Accessions	Q9D2Y4, Q8CIJ5	Gene names	Mlkl
Domain Architecture	No domain graphic available
Description	Mixed lineage kinase domain-like protein.

IRAK3_HUMAN
NC score	0.075976 (rank : 65)	θ value	θ > 10 (rank : 62)
Query Neighborhood Hits	27	Target Neighborhood Hits	644	Shared Neighborhood Hits	8
SwissProt Accessions	Q9Y616	Gene names	IRAK3
Domain Architecture	No domain graphic available
Description	Interleukin-1 receptor-associated kinase 3 (EC 2.7.11.1) (IRAK-3) (IL- 1 receptor-associated kinase M) (IRAK-M).

RIPK2_HUMAN
NC score	0.075690 (rank : 66)	θ value	θ > 10 (rank : 81)
Query Neighborhood Hits	27	Target Neighborhood Hits	774	Shared Neighborhood Hits	8
SwissProt Accessions	O43353, Q6UWF0	Gene names	RIPK2, CARDIAK, RICK, RIP2
Domain Architecture
Description	Receptor-interacting serine/threonine-protein kinase 2 (EC 2.7.11.1) (RIP-like-interacting CLARP kinase) (Receptor-interacting protein 2) (RIP-2) (CARD-containing interleukin-1 beta-converting enzyme- associated kinase) (CARD-containing IL-1 beta ICE-kinase).

KSR1_HUMAN
NC score	0.074918 (rank : 67)	θ value	θ > 10 (rank : 66)
Query Neighborhood Hits	27	Target Neighborhood Hits	867	Shared Neighborhood Hits	8
SwissProt Accessions	Q8IVT5, Q13476	Gene names	KSR1, KSR
Domain Architecture	No domain graphic available
Description	Kinase suppressor of ras-1 (Kinase suppressor of ras).

KSR1_MOUSE
NC score	0.074854 (rank : 68)	θ value	θ > 10 (rank : 67)
Query Neighborhood Hits	27	Target Neighborhood Hits	870	Shared Neighborhood Hits	8
SwissProt Accessions	Q61097, Q61648, Q78DX8	Gene names	Ksr1, Ksr
Domain Architecture	No domain graphic available
Description	Kinase suppressor of ras-1 (Kinase suppressor of ras) (mKSR1) (Hb protein).

IRAK3_MOUSE
NC score	0.073688 (rank : 69)	θ value	θ > 10 (rank : 63)
Query Neighborhood Hits	27	Target Neighborhood Hits	628	Shared Neighborhood Hits	8
SwissProt Accessions	Q8K4B2, Q8C7U8, Q8CE40, Q8K1S8	Gene names	Irak3
Domain Architecture	No domain graphic available
Description	Interleukin-1 receptor-associated kinase 3 (EC 2.7.11.1) (IRAK-3) (IL- 1 receptor-associated kinase M) (IRAK-M).

RIPK2_MOUSE
NC score	0.073112 (rank : 70)	θ value	θ > 10 (rank : 82)
Query Neighborhood Hits	27	Target Neighborhood Hits	776	Shared Neighborhood Hits	8
SwissProt Accessions	P58801	Gene names	Ripk2
Domain Architecture
Description	Receptor-interacting serine/threonine-protein kinase 2 (EC 2.7.11.1).

V2R1B_MOUSE
NC score	0.071156 (rank : 71)	θ value	θ > 10 (rank : 94)
Query Neighborhood Hits	27	Target Neighborhood Hits	39	Shared Neighborhood Hits	11
SwissProt Accessions	Q6TAC4, O70409	Gene names	V2r1b
Domain Architecture	No domain graphic available
Description	Vomeronasal type-2 receptor 1b precursor (Putative pheromone receptor V2R1b).

KSR2_HUMAN
NC score	0.067970 (rank : 72)	θ value	θ > 10 (rank : 68)
Query Neighborhood Hits	27	Target Neighborhood Hits	920	Shared Neighborhood Hits	8
SwissProt Accessions	Q6VAB6, Q8N775	Gene names	KSR2
Domain Architecture	No domain graphic available
Description	Kinase suppressor of ras-2 (hKSR2).

ILK1_HUMAN
NC score	0.066408 (rank : 73)	θ value	θ > 10 (rank : 58)
Query Neighborhood Hits	27	Target Neighborhood Hits	857	Shared Neighborhood Hits	8
SwissProt Accessions	Q13418	Gene names	ILK, ILK1
Domain Architecture
Description	Integrin-linked protein kinase 1 (EC 2.7.11.1) (ILK-1) (59 kDa serine/threonine-protein kinase) (p59ILK).

ILK_MOUSE
NC score	0.066050 (rank : 74)	θ value	θ > 10 (rank : 59)
Query Neighborhood Hits	27	Target Neighborhood Hits	858	Shared Neighborhood Hits	8
SwissProt Accessions	O55222	Gene names	Ilk
Domain Architecture
Description	Integrin-linked protein kinase (EC 2.7.11.1).

RIPK1_MOUSE
NC score	0.061657 (rank : 75)	θ value	θ > 10 (rank : 80)
Query Neighborhood Hits	27	Target Neighborhood Hits	874	Shared Neighborhood Hits	8
SwissProt Accessions	Q60855, Q3U0J3, Q8CD90	Gene names	Ripk1, Rinp, Rip
Domain Architecture
Description	Receptor-interacting serine/threonine-protein kinase 1 (EC 2.7.11.1) (Serine/threonine-protein kinase RIP) (Cell death protein RIP) (Receptor-interacting protein).

RIPK3_MOUSE
NC score	0.059300 (rank : 76)	θ value	θ > 10 (rank : 84)
Query Neighborhood Hits	27	Target Neighborhood Hits	867	Shared Neighborhood Hits	8
SwissProt Accessions	Q9QZL0	Gene names	Ripk3, Rip3
Domain Architecture
Description	Receptor-interacting serine/threonine-protein kinase 3 (EC 2.7.11.1) (RIP-like protein kinase 3) (Receptor-interacting protein 3) (RIP-3) (mRIP3).

RIPK1_HUMAN
NC score	0.058528 (rank : 77)	θ value	θ > 10 (rank : 79)
Query Neighborhood Hits	27	Target Neighborhood Hits	891	Shared Neighborhood Hits	8
SwissProt Accessions	Q13546, Q13180	Gene names	RIPK1, RIP
Domain Architecture
Description	Receptor-interacting serine/threonine-protein kinase 1 (EC 2.7.11.1) (Serine/threonine-protein kinase RIP) (Cell death protein RIP) (Receptor-interacting protein).

RIPK3_HUMAN
NC score	0.058403 (rank : 78)	θ value	θ > 10 (rank : 83)
Query Neighborhood Hits	27	Target Neighborhood Hits	828	Shared Neighborhood Hits	8
SwissProt Accessions	Q9Y572	Gene names	RIPK3, RIP3
Domain Architecture
Description	Receptor-interacting serine/threonine-protein kinase 3 (EC 2.7.11.1) (RIP-like protein kinase 3) (Receptor-interacting protein 3) (RIP-3).

GP156_HUMAN
NC score	0.057407 (rank : 79)	θ value	θ > 10 (rank : 54)
Query Neighborhood Hits	27	Target Neighborhood Hits	84	Shared Neighborhood Hits	7
SwissProt Accessions	Q8NFN8, Q86SN6	Gene names	GPR156, GABABL, PGR28
Domain Architecture	No domain graphic available
Description	Probable G-protein coupled receptor 156 (GABAB-related G-protein coupled receptor) (G-protein coupled receptor PGR28).

TOPK_HUMAN
NC score	0.055335 (rank : 80)	θ value	θ > 10 (rank : 88)
Query Neighborhood Hits	27	Target Neighborhood Hits	605	Shared Neighborhood Hits	8
SwissProt Accessions	Q96KB5, Q9NPD9, Q9NYL7, Q9NZK6	Gene names	PBK, TOPK
Domain Architecture	No domain graphic available
Description	T-lymphokine-activated killer cell-originated protein kinase (EC 2.7.12.2) (T-LAK cell-originated protein kinase) (PDZ-binding kinase) (Spermatogenesis-related protein kinase) (SPK) (MAPKK-like protein kinase) (Nori-3).

MLTK_MOUSE
NC score	0.054980 (rank : 81)	θ value	θ > 10 (rank : 77)
Query Neighborhood Hits	27	Target Neighborhood Hits	874	Shared Neighborhood Hits	8
SwissProt Accessions	Q9ESL4, Q3V1X8, Q8BR73, Q9ESL3	Gene names	Mltk
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase MLT (EC 2.7.11.25) (MLK-like mitogen-activated protein triple kinase) (Leucine zipper- and sterile alpha motif kinase ZAK) (Sterile alpha motif- and leucine zipper-containing kinase AZK) (Mixed lineage kinase-related kinase) (MLK-related kinase) (MRK).

MLTK_HUMAN
NC score	0.054848 (rank : 82)	θ value	θ > 10 (rank : 76)
Query Neighborhood Hits	27	Target Neighborhood Hits	911	Shared Neighborhood Hits	8
SwissProt Accessions	Q9NYL2, Q53SX1, Q580W8, Q59GY5, Q86YW8, Q9HCC4, Q9HCC5, Q9HDD2, Q9NYE9	Gene names	MLTK, ZAK
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase MLT (EC 2.7.11.25) (MLK-like mitogen-activated protein triple kinase) (Leucine zipper- and sterile alpha motif-containing kinase) (Sterile alpha motif- and leucine zipper-containing kinase AZK) (Mixed lineage kinase-related kinase) (MLK-related kinase) (MRK) (Cervical cancer suppressor gene 4 protein).

ANKK1_HUMAN
NC score	0.054697 (rank : 83)	θ value	θ > 10 (rank : 44)
Query Neighborhood Hits	27	Target Neighborhood Hits	1075	Shared Neighborhood Hits	8
SwissProt Accessions	Q8NFD2	Gene names	ANKK1, PKK2
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and protein kinase domain-containing protein 1 (EC 2.7.11.1) (Protein kinase PKK2) (X-kinase) (SgK288).

TOPK_MOUSE
NC score	0.054414 (rank : 84)	θ value	θ > 10 (rank : 89)
Query Neighborhood Hits	27	Target Neighborhood Hits	618	Shared Neighborhood Hits	8
SwissProt Accessions	Q9JJ78, Q922V2, Q9D184	Gene names	Pbk, Topk
Domain Architecture	No domain graphic available
Description	T-lymphokine-activated killer cell-originated protein kinase (EC 2.7.12.2) (T-LAK cell-originated protein kinase) (PDZ-binding kinase).

RIPK4_HUMAN
NC score	0.054323 (rank : 85)	θ value	θ > 10 (rank : 85)
Query Neighborhood Hits	27	Target Neighborhood Hits	1094	Shared Neighborhood Hits	8
SwissProt Accessions	P57078, Q96KH0	Gene names	RIPK4, ANKRD3, DIK
Domain Architecture
Description	Receptor-interacting serine/threonine-protein kinase 4 (EC 2.7.11.1) (Ankyrin repeat domain protein 3) (PKC-delta-interacting protein kinase).

IRAK4_MOUSE
NC score	0.053489 (rank : 86)	θ value	θ > 10 (rank : 65)
Query Neighborhood Hits	27	Target Neighborhood Hits	820	Shared Neighborhood Hits	8
SwissProt Accessions	Q8R4K2, Q80WW1	Gene names	Irak4
Domain Architecture	No domain graphic available
Description	Interleukin-1 receptor-associated kinase 4 (EC 2.7.11.1) (IRAK-4).

IRAK4_HUMAN
NC score	0.053473 (rank : 87)	θ value	θ > 10 (rank : 64)
Query Neighborhood Hits	27	Target Neighborhood Hits	816	Shared Neighborhood Hits	8
SwissProt Accessions	Q9NWZ3, Q8TDF7, Q9Y589	Gene names	IRAK4
Domain Architecture	No domain graphic available
Description	Interleukin-1 receptor-associated kinase 4 (EC 2.7.11.1) (IRAK-4) (NY- REN-64 antigen).

IRAK1_MOUSE
NC score	0.053370 (rank : 88)	θ value	θ > 10 (rank : 61)
Query Neighborhood Hits	27	Target Neighborhood Hits	784	Shared Neighborhood Hits	8
SwissProt Accessions	Q62406, Q6Y3Z5, Q6Y3Z6	Gene names	Irak1, Il1rak
Domain Architecture
Description	Interleukin-1 receptor-associated kinase 1 (EC 2.7.11.1) (IRAK-1) (IRAK) (Pelle-like protein kinase) (mPLK).

IRAK1_HUMAN
NC score	0.053302 (rank : 89)	θ value	θ > 10 (rank : 60)
Query Neighborhood Hits	27	Target Neighborhood Hits	820	Shared Neighborhood Hits	8
SwissProt Accessions	P51617, Q7Z5V4, Q96RL2	Gene names	IRAK1, IRAK
Domain Architecture
Description	Interleukin-1 receptor-associated kinase 1 (EC 2.7.11.1) (IRAK-1).

TESK2_HUMAN
NC score	0.051443 (rank : 90)	θ value	θ > 10 (rank : 86)
Query Neighborhood Hits	27	Target Neighborhood Hits	851	Shared Neighborhood Hits	8
SwissProt Accessions	Q96S53, Q8N520, Q9Y3Q6	Gene names	TESK2
Domain Architecture
Description	Dual specificity testis-specific protein kinase 2 (EC 2.7.12.1) (Testicular protein kinase 2).

TESK2_MOUSE
NC score	0.051024 (rank : 91)	θ value	θ > 10 (rank : 87)
Query Neighborhood Hits	27	Target Neighborhood Hits	833	Shared Neighborhood Hits	8
SwissProt Accessions	Q8VCT9	Gene names	Tesk2
Domain Architecture
Description	Dual specificity testis-specific protein kinase 2 (EC 2.7.12.1) (Testicular protein kinase 2).

MOS_HUMAN
NC score	0.050589 (rank : 92)	θ value	θ > 10 (rank : 78)
Query Neighborhood Hits	27	Target Neighborhood Hits	829	Shared Neighborhood Hits	8
SwissProt Accessions	P00540	Gene names	MOS
Domain Architecture
Description	Proto-oncogene serine/threonine-protein kinase mos (EC 2.7.11.1) (c- mos) (Oocyte maturation factor mos).

ANKK1_MOUSE
NC score	0.050193 (rank : 93)	θ value	θ > 10 (rank : 45)
Query Neighborhood Hits	27	Target Neighborhood Hits	1072	Shared Neighborhood Hits	8
SwissProt Accessions	Q8BZ25	Gene names	Ankk1
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and protein kinase domain-containing protein 1 (EC 2.7.11.1).

GRIK1_HUMAN
NC score	0.040299 (rank : 94)	θ value	1.06291 (rank : 19)
Query Neighborhood Hits	27	Target Neighborhood Hits	48	Shared Neighborhood Hits	10
SwissProt Accessions	P39086, Q13001, Q86SU9	Gene names	GRIK1, GLUR5
Domain Architecture
Description	Glutamate receptor, ionotropic kainate 1 precursor (Glutamate receptor 5) (GluR-5) (GluR5) (Excitatory amino acid receptor 3) (EAA3).

GRIK1_MOUSE
NC score	0.037689 (rank : 95)	θ value	3.0926 (rank : 22)
Query Neighborhood Hits	27	Target Neighborhood Hits	46	Shared Neighborhood Hits	10
SwissProt Accessions	Q60934	Gene names	Grik1, Glur5
Domain Architecture
Description	Glutamate receptor, ionotropic kainate 1 precursor (Glutamate receptor 5) (GluR-5) (GluR5).