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Network neighborhood for query Sequence : GCYB1_MOUSE

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GCYB1_MOUSE
SwissProt Accessions	O54865	Gene names	Gucy1b3
Domain Architecture	No domain graphic available
Description	Guanylate cyclase soluble subunit beta-1 (EC 4.6.1.2) (GCS-beta-1) (Soluble guanylate cyclase small subunit).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

GCYB1_HUMAN
θ value	0 (rank : 1)	NC score	0.999884 (rank : 2)
Query Neighborhood Hits	40	Target Neighborhood Hits	41	Shared Neighborhood Hits	40
SwissProt Accessions	Q02153, Q86WY5	Gene names	GUCY1B3, GUC1B3, GUCSB3, GUCY1B1
Domain Architecture
Description	Guanylate cyclase soluble subunit beta-1 (EC 4.6.1.2) (GCS-beta-1) (Soluble guanylate cyclase small subunit) (GCS-beta-3).

GCYB1_MOUSE
θ value	0 (rank : 2)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	40	Target Neighborhood Hits	40	Shared Neighborhood Hits	40
SwissProt Accessions	O54865	Gene names	Gucy1b3
Domain Architecture	No domain graphic available
Description	Guanylate cyclase soluble subunit beta-1 (EC 4.6.1.2) (GCS-beta-1) (Soluble guanylate cyclase small subunit).

GCYA2_HUMAN
θ value	7.66637e-92 (rank : 3)	NC score	0.968924 (rank : 3)
Query Neighborhood Hits	40	Target Neighborhood Hits	50	Shared Neighborhood Hits	31
SwissProt Accessions	P33402	Gene names	GUCY1A2, GUC1A2, GUCSA2
Domain Architecture
Description	Guanylate cyclase soluble subunit alpha-2 (EC 4.6.1.2) (GCS-alpha-2).

GCYA3_HUMAN
θ value	4.36332e-79 (rank : 4)	NC score	0.959328 (rank : 5)
Query Neighborhood Hits	40	Target Neighborhood Hits	36	Shared Neighborhood Hits	31
SwissProt Accessions	Q02108, O43843, Q8TAH3	Gene names	GUCY1A3, GUC1A3, GUCSA3, GUCY1A1
Domain Architecture
Description	Guanylate cyclase soluble subunit alpha-3 (EC 4.6.1.2) (GCS-alpha-3) (Soluble guanylate cyclase large subunit) (GCS-alpha-1).

GCYA3_MOUSE
θ value	1.5519e-76 (rank : 5)	NC score	0.957991 (rank : 6)
Query Neighborhood Hits	40	Target Neighborhood Hits	41	Shared Neighborhood Hits	31
SwissProt Accessions	Q9ERL9, Q9DBQ3	Gene names	Gucy1a3, Gucy1a1
Domain Architecture
Description	Guanylate cyclase soluble subunit alpha-3 (EC 4.6.1.2) (GCS-alpha-3) (Soluble guanylate cyclase large subunit) (GCS-alpha-1).

GCYB2_HUMAN
θ value	1.71583e-75 (rank : 6)	NC score	0.964452 (rank : 4)
Query Neighborhood Hits	40	Target Neighborhood Hits	61	Shared Neighborhood Hits	31
SwissProt Accessions	O75343, Q9NZ64	Gene names	GUCY1B2
Domain Architecture
Description	Guanylate cyclase soluble subunit beta-2 (EC 4.6.1.2) (GCS-beta-2).

ANPRA_MOUSE
θ value	1.01529e-43 (rank : 7)	NC score	0.535348 (rank : 27)
Query Neighborhood Hits	40	Target Neighborhood Hits	600	Shared Neighborhood Hits	31
SwissProt Accessions	P18293	Gene names	Npr1, Npra
Domain Architecture
Description	Atrial natriuretic peptide receptor A precursor (ANP-A) (ANPRA) (GC-A) (Guanylate cyclase) (EC 4.6.1.2) (NPR-A) (Atrial natriuretic peptide A-type receptor).

ANPRB_HUMAN
θ value	1.91475e-42 (rank : 8)	NC score	0.528695 (rank : 29)
Query Neighborhood Hits	40	Target Neighborhood Hits	646	Shared Neighborhood Hits	31
SwissProt Accessions	P20594, O60871, Q9UQ50	Gene names	NPR2, ANPRB
Domain Architecture
Description	Atrial natriuretic peptide receptor B precursor (ANP-B) (ANPRB) (GC-B) (Guanylate cyclase B) (EC 4.6.1.2) (NPR-B) (Atrial natriuretic peptide B-type receptor).

ANPRB_MOUSE
θ value	2.50074e-42 (rank : 9)	NC score	0.545381 (rank : 26)
Query Neighborhood Hits	40	Target Neighborhood Hits	607	Shared Neighborhood Hits	31
SwissProt Accessions	Q6VVW5, Q6VVW3, Q6VVW4, Q8CGA9	Gene names	Npr2
Domain Architecture	No domain graphic available
Description	Atrial natriuretic peptide receptor B precursor (ANP-B) (ANPRB) (GC-B) (Guanylate cyclase B) (EC 4.6.1.2) (NPR-B) (Atrial natriuretic peptide B-type receptor).

ANPRA_HUMAN
θ value	3.26607e-42 (rank : 10)	NC score	0.534259 (rank : 28)
Query Neighborhood Hits	40	Target Neighborhood Hits	612	Shared Neighborhood Hits	31
SwissProt Accessions	P16066, Q6P4Q3	Gene names	NPR1, ANPRA
Domain Architecture
Description	Atrial natriuretic peptide receptor A precursor (ANP-A) (ANPRA) (GC-A) (Guanylate cyclase) (EC 4.6.1.2) (NPR-A) (Atrial natriuretic peptide A-type receptor).

GUC2E_MOUSE
θ value	1.98146e-39 (rank : 11)	NC score	0.590337 (rank : 23)
Query Neighborhood Hits	40	Target Neighborhood Hits	692	Shared Neighborhood Hits	31
SwissProt Accessions	P52785	Gene names	Gucy2e, Guc2e
Domain Architecture
Description	Guanylyl cyclase GC-E precursor (EC 4.6.1.2) (Guanylate cyclase 2E).

GUC2F_HUMAN
θ value	4.41421e-39 (rank : 12)	NC score	0.498180 (rank : 31)
Query Neighborhood Hits	40	Target Neighborhood Hits	740	Shared Neighborhood Hits	31
SwissProt Accessions	P51841, Q9UJF1	Gene names	GUCY2F, GUC2F, RETGC2
Domain Architecture
Description	Retinal guanylyl cyclase 2 precursor (EC 4.6.1.2) (Guanylate cyclase 2F, retinal) (RETGC-2) (Rod outer segment membrane guanylate cyclase 2) (ROS-GC2) (Guanylate cyclase F) (GC-F).

GUC2D_HUMAN
θ value	5.76516e-39 (rank : 13)	NC score	0.588137 (rank : 24)
Query Neighborhood Hits	40	Target Neighborhood Hits	715	Shared Neighborhood Hits	31
SwissProt Accessions	Q02846, Q6LEA7	Gene names	GUCY2D, CORD6, GUC1A4, GUC2D, RETGC, RETGC1
Domain Architecture
Description	Retinal guanylyl cyclase 1 precursor (EC 4.6.1.2) (Guanylate cyclase 2D, retinal) (RETGC-1) (Rod outer segment membrane guanylate cyclase) (ROS-GC).

GUC2G_MOUSE
θ value	1.6774e-38 (rank : 14)	NC score	0.547358 (rank : 25)
Query Neighborhood Hits	40	Target Neighborhood Hits	644	Shared Neighborhood Hits	31
SwissProt Accessions	Q6TL19, Q8BWU7	Gene names	Gucy2g
Domain Architecture	No domain graphic available
Description	Guanylate cyclase 2G precursor (EC 4.6.1.2) (Guanylyl cyclase receptor G) (mGC-G).

GUC2C_HUMAN
θ value	1.73584e-35 (rank : 15)	NC score	0.515250 (rank : 30)
Query Neighborhood Hits	40	Target Neighborhood Hits	624	Shared Neighborhood Hits	31
SwissProt Accessions	P25092	Gene names	GUCY2C, GUC2C, STAR
Domain Architecture
Description	Heat-stable enterotoxin receptor precursor (GC-C) (Intestinal guanylate cyclase) (EC 4.6.1.2) (STA receptor) (hSTAR).

ADCY1_HUMAN
θ value	1.62847e-25 (rank : 16)	NC score	0.793630 (rank : 9)
Query Neighborhood Hits	40	Target Neighborhood Hits	42	Shared Neighborhood Hits	31
SwissProt Accessions	Q08828, Q75MI1	Gene names	ADCY1
Domain Architecture	No domain graphic available
Description	Adenylate cyclase type 1 (EC 4.6.1.1) (Adenylate cyclase type I) (ATP pyrophosphate-lyase 1) (Ca(2+)/calmodulin-activated adenylyl cyclase).

ADCY1_MOUSE
θ value	1.62847e-25 (rank : 17)	NC score	0.790751 (rank : 10)
Query Neighborhood Hits	40	Target Neighborhood Hits	40	Shared Neighborhood Hits	31
SwissProt Accessions	O88444, Q5SS89	Gene names	Adcy1
Domain Architecture	No domain graphic available
Description	Adenylate cyclase type 1 (EC 4.6.1.1) (Adenylate cyclase type I) (ATP pyrophosphate-lyase 1) (Ca(2+)/calmodulin-activated adenylyl cyclase).

ADCY8_HUMAN
θ value	6.84181e-24 (rank : 18)	NC score	0.778812 (rank : 14)
Query Neighborhood Hits	40	Target Neighborhood Hits	41	Shared Neighborhood Hits	31
SwissProt Accessions	P40145	Gene names	ADCY8
Domain Architecture
Description	Adenylate cyclase type 8 (EC 4.6.1.1) (Adenylate cyclase type VIII) (ATP pyrophosphate-lyase 8) (Ca(2+)/calmodulin-activated adenylyl cyclase).

ADCY8_MOUSE
θ value	6.84181e-24 (rank : 19)	NC score	0.778445 (rank : 15)
Query Neighborhood Hits	40	Target Neighborhood Hits	42	Shared Neighborhood Hits	31
SwissProt Accessions	P97490	Gene names	Adcy8
Domain Architecture
Description	Adenylate cyclase type 8 (EC 4.6.1.1) (Adenylate cyclase type VIII) (ATP pyrophosphate-lyase 8) (Ca(2+)/calmodulin-activated adenylyl cyclase).

ADCY9_HUMAN
θ value	9.87957e-23 (rank : 20)	NC score	0.803164 (rank : 7)
Query Neighborhood Hits	40	Target Neighborhood Hits	51	Shared Neighborhood Hits	31
SwissProt Accessions	O60503, O60273, Q4ZHT9, Q4ZIR5, Q9BWT4, Q9UGP2	Gene names	ADCY9, KIAA0520
Domain Architecture
Description	Adenylate cyclase type 9 (EC 4.6.1.1) (Adenylate cyclase type IX) (ATP pyrophosphate-lyase 9) (Adenylyl cyclase 9).

ADCY9_MOUSE
θ value	9.87957e-23 (rank : 21)	NC score	0.802874 (rank : 8)
Query Neighborhood Hits	40	Target Neighborhood Hits	46	Shared Neighborhood Hits	31
SwissProt Accessions	P51830, Q61279	Gene names	Adcy9
Domain Architecture
Description	Adenylate cyclase type 9 (EC 4.6.1.1) (Adenylate cyclase type IX) (ATP pyrophosphate-lyase 9) (Adenylyl cyclase 9) (Adenylyl cyclase type 10) (ACTP10).

ADCY6_HUMAN
θ value	1.6852e-22 (rank : 22)	NC score	0.780336 (rank : 13)
Query Neighborhood Hits	40	Target Neighborhood Hits	52	Shared Neighborhood Hits	31
SwissProt Accessions	O43306, Q9NR75	Gene names	ADCY6, KIAA0422
Domain Architecture
Description	Adenylate cyclase type 6 (EC 4.6.1.1) (Adenylate cyclase type VI) (ATP pyrophosphate-lyase 6) (Ca(2+)-inhibitable adenylyl cyclase).

ADCY4_MOUSE
θ value	3.75424e-22 (rank : 23)	NC score	0.778203 (rank : 16)
Query Neighborhood Hits	40	Target Neighborhood Hits	40	Shared Neighborhood Hits	31
SwissProt Accessions	Q91WF3	Gene names	Adcy4
Domain Architecture
Description	Adenylate cyclase type 4 (EC 4.6.1.1) (Adenylate cyclase type IV) (ATP pyrophosphate-lyase 4) (Adenylyl cyclase 4).

ADCY7_MOUSE
θ value	3.75424e-22 (rank : 24)	NC score	0.778116 (rank : 17)
Query Neighborhood Hits	40	Target Neighborhood Hits	37	Shared Neighborhood Hits	31
SwissProt Accessions	P51829	Gene names	Adcy7
Domain Architecture
Description	Adenylate cyclase type 7 (EC 4.6.1.1) (Adenylate cyclase type VII) (ATP pyrophosphate-lyase 7) (Adenylyl cyclase 7).

ADCY3_HUMAN
θ value	1.09232e-21 (rank : 25)	NC score	0.784381 (rank : 12)
Query Neighborhood Hits	40	Target Neighborhood Hits	58	Shared Neighborhood Hits	31
SwissProt Accessions	O60266, Q9UDB1	Gene names	ADCY3, KIAA0511
Domain Architecture
Description	Adenylate cyclase type 3 (EC 4.6.1.1) (Adenylate cyclase type III) (Adenylate cyclase, olfactive type) (ATP pyrophosphate-lyase 3) (Adenylyl cyclase 3) (AC-III) (AC3).

ADCY7_HUMAN
θ value	1.09232e-21 (rank : 26)	NC score	0.776377 (rank : 19)
Query Neighborhood Hits	40	Target Neighborhood Hits	44	Shared Neighborhood Hits	31
SwissProt Accessions	P51828	Gene names	ADCY7, KIAA0037
Domain Architecture	No domain graphic available
Description	Adenylate cyclase type 7 (EC 4.6.1.1) (Adenylate cyclase type VII) (ATP pyrophosphate-lyase 7) (Adenylyl cyclase 7).

ADCY3_MOUSE
θ value	2.43343e-21 (rank : 27)	NC score	0.787020 (rank : 11)
Query Neighborhood Hits	40	Target Neighborhood Hits	47	Shared Neighborhood Hits	31
SwissProt Accessions	Q8VHH7	Gene names	Adcy3
Domain Architecture
Description	Adenylate cyclase type 3 (EC 4.6.1.1) (Adenylate cyclase type III) (Adenylate cyclase, olfactive type) (ATP pyrophosphate-lyase 3) (Adenylyl cyclase 3) (AC-III) (AC3).

ADCY2_HUMAN
θ value	5.42112e-21 (rank : 28)	NC score	0.772086 (rank : 21)
Query Neighborhood Hits	40	Target Neighborhood Hits	38	Shared Neighborhood Hits	31
SwissProt Accessions	Q08462, Q9UPU2	Gene names	ADCY2, KIAA1060
Domain Architecture
Description	Adenylate cyclase type 2 (EC 4.6.1.1) (Adenylate cyclase type II) (ATP pyrophosphate-lyase 2) (Adenylyl cyclase 2).

ADCY2_MOUSE
θ value	5.42112e-21 (rank : 29)	NC score	0.769247 (rank : 22)
Query Neighborhood Hits	40	Target Neighborhood Hits	38	Shared Neighborhood Hits	31
SwissProt Accessions	Q80TL1, Q8CFU6	Gene names	Adcy2, Kiaa1060
Domain Architecture	No domain graphic available
Description	Adenylate cyclase type 2 (EC 4.6.1.1) (Adenylate cyclase type II) (ATP pyrophosphate-lyase 2) (Adenylyl cyclase 2).

ADCY6_MOUSE
θ value	5.42112e-21 (rank : 30)	NC score	0.777313 (rank : 18)
Query Neighborhood Hits	40	Target Neighborhood Hits	57	Shared Neighborhood Hits	31
SwissProt Accessions	Q01341	Gene names	Adcy6
Domain Architecture
Description	Adenylate cyclase type 6 (EC 4.6.1.1) (Adenylate cyclase type VI) (ATP pyrophosphate-lyase 6) (Ca(2+)-inhibitable adenylyl cyclase).

ADCY4_HUMAN
θ value	9.24701e-21 (rank : 31)	NC score	0.776249 (rank : 20)
Query Neighborhood Hits	40	Target Neighborhood Hits	41	Shared Neighborhood Hits	31
SwissProt Accessions	Q8NFM4, Q96ML7	Gene names	ADCY4
Domain Architecture
Description	Adenylate cyclase type 4 (EC 4.6.1.1) (Adenylate cyclase type IV) (ATP pyrophosphate-lyase 4) (Adenylyl cyclase 4).

FRAS1_MOUSE
θ value	0.47712 (rank : 32)	NC score	0.010793 (rank : 57)
Query Neighborhood Hits	40	Target Neighborhood Hits	747	Shared Neighborhood Hits	3
SwissProt Accessions	Q80T14, Q80TC7, Q811H8, Q8BPZ4	Gene names	Fras1, Kiaa1500
Domain Architecture	No domain graphic available
Description	Extracellular matrix protein FRAS1 precursor.

CF152_HUMAN
θ value	1.06291 (rank : 33)	NC score	0.014409 (rank : 56)
Query Neighborhood Hits	40	Target Neighborhood Hits	704	Shared Neighborhood Hits	4
SwissProt Accessions	Q86VQ0, Q9BWX7	Gene names	C6orf152
Domain Architecture	No domain graphic available
Description	Protein C6orf152.

CCD24_HUMAN
θ value	2.36792 (rank : 34)	NC score	0.040000 (rank : 55)
Query Neighborhood Hits	40	Target Neighborhood Hits	23	Shared Neighborhood Hits	3
SwissProt Accessions	Q8N4L8, Q6RWT2	Gene names	CCDC24
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 24.

CARD9_HUMAN
θ value	4.03905 (rank : 35)	NC score	0.005404 (rank : 61)
Query Neighborhood Hits	40	Target Neighborhood Hits	602	Shared Neighborhood Hits	4
SwissProt Accessions	Q9H257, Q5SXM6, Q9H854	Gene names	CARD9
Domain Architecture
Description	Caspase recruitment domain-containing protein 9 (hCARD9).

GP120_HUMAN
θ value	4.03905 (rank : 36)	NC score	0.003313 (rank : 62)
Query Neighborhood Hits	40	Target Neighborhood Hits	458	Shared Neighborhood Hits	3
SwissProt Accessions	Q5NUL3, Q5VY25, Q5VY26, Q7Z605, Q86SM7	Gene names	GPR120, GPR129, PGR4
Domain Architecture	No domain graphic available
Description	G-protein coupled receptor 120 (G-protein coupled receptor PGR4) (G- protein coupled receptor GT01) (G-protein coupled receptor 129).

MCF2_HUMAN
θ value	6.88961 (rank : 37)	NC score	0.007948 (rank : 59)
Query Neighborhood Hits	40	Target Neighborhood Hits	166	Shared Neighborhood Hits	3
SwissProt Accessions	P10911, P14919, Q5JYJ4, Q8IUF3, Q8IUF4, Q9UJB3	Gene names	MCF2, DBL
Domain Architecture
Description	Proto-oncogene DBL (Proto-oncogene MCF-2) [Contains: MCF2-transforming protein; DBL-transforming protein].

NOL8_HUMAN
θ value	6.88961 (rank : 38)	NC score	0.009759 (rank : 58)
Query Neighborhood Hits	40	Target Neighborhood Hits	297	Shared Neighborhood Hits	3
SwissProt Accessions	Q76FK4, Q5TCC7, Q5TCC8, Q5TCD3, Q5TCD5, Q5TCD6, Q5TCD7, Q76D35, Q7L3E2, Q9H586, Q9H795, Q9H7W7, Q9H9J6, Q9NWA4, Q9NWM4	Gene names	NOL8, NOP132
Domain Architecture	No domain graphic available
Description	Nucleolar protein 8 (Nucleolar protein Nop132).

IFIH1_MOUSE
θ value	8.99809 (rank : 39)	NC score	0.006148 (rank : 60)
Query Neighborhood Hits	40	Target Neighborhood Hits	126	Shared Neighborhood Hits	3
SwissProt Accessions	Q8R5F7, Q3U6S2, Q68EM4, Q8BYC9, Q8BZ01, Q8K5C7, Q8R144, Q8VE79, Q99KS4, Q9D2Z5	Gene names	Ifih1
Domain Architecture	No domain graphic available
Description	Interferon-induced helicase C domain-containing protein 1 (EC 3.6.1.-) (Interferon induced with helicase C domain protein 1) (Helicase with 2 CARD domains) (Helicard) (Melanoma differentiation-associated protein 5) (MDA-5).

TLR10_HUMAN
θ value	8.99809 (rank : 40)	NC score	0.002644 (rank : 63)
Query Neighborhood Hits	40	Target Neighborhood Hits	295	Shared Neighborhood Hits	3
SwissProt Accessions	Q9BXR5, Q5FWG4, Q6UXL3	Gene names	TLR10
Domain Architecture
Description	Toll-like receptor 10 precursor.

ANPRC_HUMAN
θ value	θ > 10 (rank : 41)	NC score	0.264403 (rank : 32)
Query Neighborhood Hits	40	Target Neighborhood Hits	27	Shared Neighborhood Hits	8
SwissProt Accessions	P17342	Gene names	NPR3, ANPRC
Domain Architecture
Description	Atrial natriuretic peptide clearance receptor precursor (ANP-C) (ANPRC) (NPR-C) (Atrial natriuretic peptide C-type receptor).

ANPRC_MOUSE
θ value	θ > 10 (rank : 42)	NC score	0.258829 (rank : 33)
Query Neighborhood Hits	40	Target Neighborhood Hits	27	Shared Neighborhood Hits	8
SwissProt Accessions	P70180, P97804, Q9R025, Q9R027, Q9R028	Gene names	Npr3
Domain Architecture
Description	Atrial natriuretic peptide clearance receptor precursor (ANP-C) (ANPRC) (NPR-C) (Atrial natriuretic peptide C-type receptor) (EF-2).

GABR1_HUMAN
θ value	θ > 10 (rank : 43)	NC score	0.074179 (rank : 35)
Query Neighborhood Hits	40	Target Neighborhood Hits	142	Shared Neighborhood Hits	6
SwissProt Accessions	Q9UBS5, O95375, O95468, O95975, O96022, Q86W60, Q9UQQ0	Gene names	GABBR1, GPRC3A
Domain Architecture
Description	Gamma-aminobutyric acid type B receptor, subunit 1 precursor (GABA-B receptor 1) (GABA-B-R1) (Gb1).

GABR1_MOUSE
θ value	θ > 10 (rank : 44)	NC score	0.076442 (rank : 34)
Query Neighborhood Hits	40	Target Neighborhood Hits	139	Shared Neighborhood Hits	6
SwissProt Accessions	Q9WV18, Q9WU48, Q9WV15, Q9WV16, Q9WV17	Gene names	Gabbr1
Domain Architecture
Description	Gamma-aminobutyric acid type B receptor, subunit 1 precursor (GABA-B receptor 1) (GABA-B-R1) (Gb1).

ILK1_HUMAN
θ value	θ > 10 (rank : 45)	NC score	0.058478 (rank : 48)
Query Neighborhood Hits	40	Target Neighborhood Hits	857	Shared Neighborhood Hits	9
SwissProt Accessions	Q13418	Gene names	ILK, ILK1
Domain Architecture
Description	Integrin-linked protein kinase 1 (EC 2.7.11.1) (ILK-1) (59 kDa serine/threonine-protein kinase) (p59ILK).

ILK_MOUSE
θ value	θ > 10 (rank : 46)	NC score	0.058762 (rank : 47)
Query Neighborhood Hits	40	Target Neighborhood Hits	858	Shared Neighborhood Hits	9
SwissProt Accessions	O55222	Gene names	Ilk
Domain Architecture
Description	Integrin-linked protein kinase (EC 2.7.11.1).

IRAK3_HUMAN
θ value	θ > 10 (rank : 47)	NC score	0.071207 (rank : 36)
Query Neighborhood Hits	40	Target Neighborhood Hits	644	Shared Neighborhood Hits	9
SwissProt Accessions	Q9Y616	Gene names	IRAK3
Domain Architecture	No domain graphic available
Description	Interleukin-1 receptor-associated kinase 3 (EC 2.7.11.1) (IRAK-3) (IL- 1 receptor-associated kinase M) (IRAK-M).

IRAK3_MOUSE
θ value	θ > 10 (rank : 48)	NC score	0.069038 (rank : 40)
Query Neighborhood Hits	40	Target Neighborhood Hits	628	Shared Neighborhood Hits	9
SwissProt Accessions	Q8K4B2, Q8C7U8, Q8CE40, Q8K1S8	Gene names	Irak3
Domain Architecture	No domain graphic available
Description	Interleukin-1 receptor-associated kinase 3 (EC 2.7.11.1) (IRAK-3) (IL- 1 receptor-associated kinase M) (IRAK-M).

KSR1_HUMAN
θ value	θ > 10 (rank : 49)	NC score	0.069351 (rank : 39)
Query Neighborhood Hits	40	Target Neighborhood Hits	867	Shared Neighborhood Hits	9
SwissProt Accessions	Q8IVT5, Q13476	Gene names	KSR1, KSR
Domain Architecture	No domain graphic available
Description	Kinase suppressor of ras-1 (Kinase suppressor of ras).

KSR1_MOUSE
θ value	θ > 10 (rank : 50)	NC score	0.068414 (rank : 42)
Query Neighborhood Hits	40	Target Neighborhood Hits	870	Shared Neighborhood Hits	9
SwissProt Accessions	Q61097, Q61648, Q78DX8	Gene names	Ksr1, Ksr
Domain Architecture	No domain graphic available
Description	Kinase suppressor of ras-1 (Kinase suppressor of ras) (mKSR1) (Hb protein).

KSR2_HUMAN
θ value	θ > 10 (rank : 51)	NC score	0.062185 (rank : 44)
Query Neighborhood Hits	40	Target Neighborhood Hits	920	Shared Neighborhood Hits	9
SwissProt Accessions	Q6VAB6, Q8N775	Gene names	KSR2
Domain Architecture	No domain graphic available
Description	Kinase suppressor of ras-2 (hKSR2).

MLKL_HUMAN
θ value	θ > 10 (rank : 52)	NC score	0.068809 (rank : 41)
Query Neighborhood Hits	40	Target Neighborhood Hits	600	Shared Neighborhood Hits	9
SwissProt Accessions	Q8NB16, Q8N6V0	Gene names	MLKL
Domain Architecture	No domain graphic available
Description	Mixed lineage kinase domain-like protein.

MLKL_MOUSE
θ value	θ > 10 (rank : 53)	NC score	0.067892 (rank : 43)
Query Neighborhood Hits	40	Target Neighborhood Hits	707	Shared Neighborhood Hits	9
SwissProt Accessions	Q9D2Y4, Q8CIJ5	Gene names	Mlkl
Domain Architecture	No domain graphic available
Description	Mixed lineage kinase domain-like protein.

MLTK_HUMAN
θ value	θ > 10 (rank : 54)	NC score	0.050890 (rank : 54)
Query Neighborhood Hits	40	Target Neighborhood Hits	911	Shared Neighborhood Hits	9
SwissProt Accessions	Q9NYL2, Q53SX1, Q580W8, Q59GY5, Q86YW8, Q9HCC4, Q9HCC5, Q9HDD2, Q9NYE9	Gene names	MLTK, ZAK
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase MLT (EC 2.7.11.25) (MLK-like mitogen-activated protein triple kinase) (Leucine zipper- and sterile alpha motif-containing kinase) (Sterile alpha motif- and leucine zipper-containing kinase AZK) (Mixed lineage kinase-related kinase) (MLK-related kinase) (MRK) (Cervical cancer suppressor gene 4 protein).

MLTK_MOUSE
θ value	θ > 10 (rank : 55)	NC score	0.051202 (rank : 53)
Query Neighborhood Hits	40	Target Neighborhood Hits	874	Shared Neighborhood Hits	9
SwissProt Accessions	Q9ESL4, Q3V1X8, Q8BR73, Q9ESL3	Gene names	Mltk
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase MLT (EC 2.7.11.25) (MLK-like mitogen-activated protein triple kinase) (Leucine zipper- and sterile alpha motif kinase ZAK) (Sterile alpha motif- and leucine zipper-containing kinase AZK) (Mixed lineage kinase-related kinase) (MLK-related kinase) (MRK).

RIPK1_HUMAN
θ value	θ > 10 (rank : 56)	NC score	0.059325 (rank : 46)
Query Neighborhood Hits	40	Target Neighborhood Hits	891	Shared Neighborhood Hits	9
SwissProt Accessions	Q13546, Q13180	Gene names	RIPK1, RIP
Domain Architecture
Description	Receptor-interacting serine/threonine-protein kinase 1 (EC 2.7.11.1) (Serine/threonine-protein kinase RIP) (Cell death protein RIP) (Receptor-interacting protein).

RIPK1_MOUSE
θ value	θ > 10 (rank : 57)	NC score	0.061420 (rank : 45)
Query Neighborhood Hits	40	Target Neighborhood Hits	874	Shared Neighborhood Hits	9
SwissProt Accessions	Q60855, Q3U0J3, Q8CD90	Gene names	Ripk1, Rinp, Rip
Domain Architecture
Description	Receptor-interacting serine/threonine-protein kinase 1 (EC 2.7.11.1) (Serine/threonine-protein kinase RIP) (Cell death protein RIP) (Receptor-interacting protein).

RIPK2_HUMAN
θ value	θ > 10 (rank : 58)	NC score	0.070913 (rank : 37)
Query Neighborhood Hits	40	Target Neighborhood Hits	774	Shared Neighborhood Hits	9
SwissProt Accessions	O43353, Q6UWF0	Gene names	RIPK2, CARDIAK, RICK, RIP2
Domain Architecture
Description	Receptor-interacting serine/threonine-protein kinase 2 (EC 2.7.11.1) (RIP-like-interacting CLARP kinase) (Receptor-interacting protein 2) (RIP-2) (CARD-containing interleukin-1 beta-converting enzyme- associated kinase) (CARD-containing IL-1 beta ICE-kinase).

RIPK2_MOUSE
θ value	θ > 10 (rank : 59)	NC score	0.069365 (rank : 38)
Query Neighborhood Hits	40	Target Neighborhood Hits	776	Shared Neighborhood Hits	9
SwissProt Accessions	P58801	Gene names	Ripk2
Domain Architecture
Description	Receptor-interacting serine/threonine-protein kinase 2 (EC 2.7.11.1).

RIPK3_HUMAN
θ value	θ > 10 (rank : 60)	NC score	0.051333 (rank : 52)
Query Neighborhood Hits	40	Target Neighborhood Hits	828	Shared Neighborhood Hits	9
SwissProt Accessions	Q9Y572	Gene names	RIPK3, RIP3
Domain Architecture
Description	Receptor-interacting serine/threonine-protein kinase 3 (EC 2.7.11.1) (RIP-like protein kinase 3) (Receptor-interacting protein 3) (RIP-3).

RIPK3_MOUSE
θ value	θ > 10 (rank : 61)	NC score	0.052608 (rank : 51)
Query Neighborhood Hits	40	Target Neighborhood Hits	867	Shared Neighborhood Hits	9
SwissProt Accessions	Q9QZL0	Gene names	Ripk3, Rip3
Domain Architecture
Description	Receptor-interacting serine/threonine-protein kinase 3 (EC 2.7.11.1) (RIP-like protein kinase 3) (Receptor-interacting protein 3) (RIP-3) (mRIP3).

TOPK_HUMAN
θ value	θ > 10 (rank : 62)	NC score	0.055452 (rank : 49)
Query Neighborhood Hits	40	Target Neighborhood Hits	605	Shared Neighborhood Hits	9
SwissProt Accessions	Q96KB5, Q9NPD9, Q9NYL7, Q9NZK6	Gene names	PBK, TOPK
Domain Architecture	No domain graphic available
Description	T-lymphokine-activated killer cell-originated protein kinase (EC 2.7.12.2) (T-LAK cell-originated protein kinase) (PDZ-binding kinase) (Spermatogenesis-related protein kinase) (SPK) (MAPKK-like protein kinase) (Nori-3).

TOPK_MOUSE
θ value	θ > 10 (rank : 63)	NC score	0.052902 (rank : 50)
Query Neighborhood Hits	40	Target Neighborhood Hits	618	Shared Neighborhood Hits	9
SwissProt Accessions	Q9JJ78, Q922V2, Q9D184	Gene names	Pbk, Topk
Domain Architecture	No domain graphic available
Description	T-lymphokine-activated killer cell-originated protein kinase (EC 2.7.12.2) (T-LAK cell-originated protein kinase) (PDZ-binding kinase).

Hits sorted by NC score

GCYB1_MOUSE
NC score	0.999962 (rank : 1)	θ value	0 (rank : 2)
Query Neighborhood Hits	40	Target Neighborhood Hits	40	Shared Neighborhood Hits	40
SwissProt Accessions	O54865	Gene names	Gucy1b3
Domain Architecture	No domain graphic available
Description	Guanylate cyclase soluble subunit beta-1 (EC 4.6.1.2) (GCS-beta-1) (Soluble guanylate cyclase small subunit).

GCYB1_HUMAN
NC score	0.999884 (rank : 2)	θ value	0 (rank : 1)
Query Neighborhood Hits	40	Target Neighborhood Hits	41	Shared Neighborhood Hits	40
SwissProt Accessions	Q02153, Q86WY5	Gene names	GUCY1B3, GUC1B3, GUCSB3, GUCY1B1
Domain Architecture
Description	Guanylate cyclase soluble subunit beta-1 (EC 4.6.1.2) (GCS-beta-1) (Soluble guanylate cyclase small subunit) (GCS-beta-3).

GCYA2_HUMAN
NC score	0.968924 (rank : 3)	θ value	7.66637e-92 (rank : 3)
Query Neighborhood Hits	40	Target Neighborhood Hits	50	Shared Neighborhood Hits	31
SwissProt Accessions	P33402	Gene names	GUCY1A2, GUC1A2, GUCSA2
Domain Architecture
Description	Guanylate cyclase soluble subunit alpha-2 (EC 4.6.1.2) (GCS-alpha-2).

GCYB2_HUMAN
NC score	0.964452 (rank : 4)	θ value	1.71583e-75 (rank : 6)
Query Neighborhood Hits	40	Target Neighborhood Hits	61	Shared Neighborhood Hits	31
SwissProt Accessions	O75343, Q9NZ64	Gene names	GUCY1B2
Domain Architecture
Description	Guanylate cyclase soluble subunit beta-2 (EC 4.6.1.2) (GCS-beta-2).

GCYA3_HUMAN
NC score	0.959328 (rank : 5)	θ value	4.36332e-79 (rank : 4)
Query Neighborhood Hits	40	Target Neighborhood Hits	36	Shared Neighborhood Hits	31
SwissProt Accessions	Q02108, O43843, Q8TAH3	Gene names	GUCY1A3, GUC1A3, GUCSA3, GUCY1A1
Domain Architecture
Description	Guanylate cyclase soluble subunit alpha-3 (EC 4.6.1.2) (GCS-alpha-3) (Soluble guanylate cyclase large subunit) (GCS-alpha-1).

GCYA3_MOUSE
NC score	0.957991 (rank : 6)	θ value	1.5519e-76 (rank : 5)
Query Neighborhood Hits	40	Target Neighborhood Hits	41	Shared Neighborhood Hits	31
SwissProt Accessions	Q9ERL9, Q9DBQ3	Gene names	Gucy1a3, Gucy1a1
Domain Architecture
Description	Guanylate cyclase soluble subunit alpha-3 (EC 4.6.1.2) (GCS-alpha-3) (Soluble guanylate cyclase large subunit) (GCS-alpha-1).

ADCY9_HUMAN
NC score	0.803164 (rank : 7)	θ value	9.87957e-23 (rank : 20)
Query Neighborhood Hits	40	Target Neighborhood Hits	51	Shared Neighborhood Hits	31
SwissProt Accessions	O60503, O60273, Q4ZHT9, Q4ZIR5, Q9BWT4, Q9UGP2	Gene names	ADCY9, KIAA0520
Domain Architecture
Description	Adenylate cyclase type 9 (EC 4.6.1.1) (Adenylate cyclase type IX) (ATP pyrophosphate-lyase 9) (Adenylyl cyclase 9).

ADCY9_MOUSE
NC score	0.802874 (rank : 8)	θ value	9.87957e-23 (rank : 21)
Query Neighborhood Hits	40	Target Neighborhood Hits	46	Shared Neighborhood Hits	31
SwissProt Accessions	P51830, Q61279	Gene names	Adcy9
Domain Architecture
Description	Adenylate cyclase type 9 (EC 4.6.1.1) (Adenylate cyclase type IX) (ATP pyrophosphate-lyase 9) (Adenylyl cyclase 9) (Adenylyl cyclase type 10) (ACTP10).

ADCY1_HUMAN
NC score	0.793630 (rank : 9)	θ value	1.62847e-25 (rank : 16)
Query Neighborhood Hits	40	Target Neighborhood Hits	42	Shared Neighborhood Hits	31
SwissProt Accessions	Q08828, Q75MI1	Gene names	ADCY1
Domain Architecture	No domain graphic available
Description	Adenylate cyclase type 1 (EC 4.6.1.1) (Adenylate cyclase type I) (ATP pyrophosphate-lyase 1) (Ca(2+)/calmodulin-activated adenylyl cyclase).

ADCY1_MOUSE
NC score	0.790751 (rank : 10)	θ value	1.62847e-25 (rank : 17)
Query Neighborhood Hits	40	Target Neighborhood Hits	40	Shared Neighborhood Hits	31
SwissProt Accessions	O88444, Q5SS89	Gene names	Adcy1
Domain Architecture	No domain graphic available
Description	Adenylate cyclase type 1 (EC 4.6.1.1) (Adenylate cyclase type I) (ATP pyrophosphate-lyase 1) (Ca(2+)/calmodulin-activated adenylyl cyclase).

ADCY3_MOUSE
NC score	0.787020 (rank : 11)	θ value	2.43343e-21 (rank : 27)
Query Neighborhood Hits	40	Target Neighborhood Hits	47	Shared Neighborhood Hits	31
SwissProt Accessions	Q8VHH7	Gene names	Adcy3
Domain Architecture
Description	Adenylate cyclase type 3 (EC 4.6.1.1) (Adenylate cyclase type III) (Adenylate cyclase, olfactive type) (ATP pyrophosphate-lyase 3) (Adenylyl cyclase 3) (AC-III) (AC3).

ADCY3_HUMAN
NC score	0.784381 (rank : 12)	θ value	1.09232e-21 (rank : 25)
Query Neighborhood Hits	40	Target Neighborhood Hits	58	Shared Neighborhood Hits	31
SwissProt Accessions	O60266, Q9UDB1	Gene names	ADCY3, KIAA0511
Domain Architecture
Description	Adenylate cyclase type 3 (EC 4.6.1.1) (Adenylate cyclase type III) (Adenylate cyclase, olfactive type) (ATP pyrophosphate-lyase 3) (Adenylyl cyclase 3) (AC-III) (AC3).

ADCY6_HUMAN
NC score	0.780336 (rank : 13)	θ value	1.6852e-22 (rank : 22)
Query Neighborhood Hits	40	Target Neighborhood Hits	52	Shared Neighborhood Hits	31
SwissProt Accessions	O43306, Q9NR75	Gene names	ADCY6, KIAA0422
Domain Architecture
Description	Adenylate cyclase type 6 (EC 4.6.1.1) (Adenylate cyclase type VI) (ATP pyrophosphate-lyase 6) (Ca(2+)-inhibitable adenylyl cyclase).

ADCY8_HUMAN
NC score	0.778812 (rank : 14)	θ value	6.84181e-24 (rank : 18)
Query Neighborhood Hits	40	Target Neighborhood Hits	41	Shared Neighborhood Hits	31
SwissProt Accessions	P40145	Gene names	ADCY8
Domain Architecture
Description	Adenylate cyclase type 8 (EC 4.6.1.1) (Adenylate cyclase type VIII) (ATP pyrophosphate-lyase 8) (Ca(2+)/calmodulin-activated adenylyl cyclase).

ADCY8_MOUSE
NC score	0.778445 (rank : 15)	θ value	6.84181e-24 (rank : 19)
Query Neighborhood Hits	40	Target Neighborhood Hits	42	Shared Neighborhood Hits	31
SwissProt Accessions	P97490	Gene names	Adcy8
Domain Architecture
Description	Adenylate cyclase type 8 (EC 4.6.1.1) (Adenylate cyclase type VIII) (ATP pyrophosphate-lyase 8) (Ca(2+)/calmodulin-activated adenylyl cyclase).

ADCY4_MOUSE
NC score	0.778203 (rank : 16)	θ value	3.75424e-22 (rank : 23)
Query Neighborhood Hits	40	Target Neighborhood Hits	40	Shared Neighborhood Hits	31
SwissProt Accessions	Q91WF3	Gene names	Adcy4
Domain Architecture
Description	Adenylate cyclase type 4 (EC 4.6.1.1) (Adenylate cyclase type IV) (ATP pyrophosphate-lyase 4) (Adenylyl cyclase 4).

ADCY7_MOUSE
NC score	0.778116 (rank : 17)	θ value	3.75424e-22 (rank : 24)
Query Neighborhood Hits	40	Target Neighborhood Hits	37	Shared Neighborhood Hits	31
SwissProt Accessions	P51829	Gene names	Adcy7
Domain Architecture
Description	Adenylate cyclase type 7 (EC 4.6.1.1) (Adenylate cyclase type VII) (ATP pyrophosphate-lyase 7) (Adenylyl cyclase 7).

ADCY6_MOUSE
NC score	0.777313 (rank : 18)	θ value	5.42112e-21 (rank : 30)
Query Neighborhood Hits	40	Target Neighborhood Hits	57	Shared Neighborhood Hits	31
SwissProt Accessions	Q01341	Gene names	Adcy6
Domain Architecture
Description	Adenylate cyclase type 6 (EC 4.6.1.1) (Adenylate cyclase type VI) (ATP pyrophosphate-lyase 6) (Ca(2+)-inhibitable adenylyl cyclase).

ADCY7_HUMAN
NC score	0.776377 (rank : 19)	θ value	1.09232e-21 (rank : 26)
Query Neighborhood Hits	40	Target Neighborhood Hits	44	Shared Neighborhood Hits	31
SwissProt Accessions	P51828	Gene names	ADCY7, KIAA0037
Domain Architecture	No domain graphic available
Description	Adenylate cyclase type 7 (EC 4.6.1.1) (Adenylate cyclase type VII) (ATP pyrophosphate-lyase 7) (Adenylyl cyclase 7).

ADCY4_HUMAN
NC score	0.776249 (rank : 20)	θ value	9.24701e-21 (rank : 31)
Query Neighborhood Hits	40	Target Neighborhood Hits	41	Shared Neighborhood Hits	31
SwissProt Accessions	Q8NFM4, Q96ML7	Gene names	ADCY4
Domain Architecture
Description	Adenylate cyclase type 4 (EC 4.6.1.1) (Adenylate cyclase type IV) (ATP pyrophosphate-lyase 4) (Adenylyl cyclase 4).

ADCY2_HUMAN
NC score	0.772086 (rank : 21)	θ value	5.42112e-21 (rank : 28)
Query Neighborhood Hits	40	Target Neighborhood Hits	38	Shared Neighborhood Hits	31
SwissProt Accessions	Q08462, Q9UPU2	Gene names	ADCY2, KIAA1060
Domain Architecture
Description	Adenylate cyclase type 2 (EC 4.6.1.1) (Adenylate cyclase type II) (ATP pyrophosphate-lyase 2) (Adenylyl cyclase 2).

ADCY2_MOUSE
NC score	0.769247 (rank : 22)	θ value	5.42112e-21 (rank : 29)
Query Neighborhood Hits	40	Target Neighborhood Hits	38	Shared Neighborhood Hits	31
SwissProt Accessions	Q80TL1, Q8CFU6	Gene names	Adcy2, Kiaa1060
Domain Architecture	No domain graphic available
Description	Adenylate cyclase type 2 (EC 4.6.1.1) (Adenylate cyclase type II) (ATP pyrophosphate-lyase 2) (Adenylyl cyclase 2).

GUC2E_MOUSE
NC score	0.590337 (rank : 23)	θ value	1.98146e-39 (rank : 11)
Query Neighborhood Hits	40	Target Neighborhood Hits	692	Shared Neighborhood Hits	31
SwissProt Accessions	P52785	Gene names	Gucy2e, Guc2e
Domain Architecture
Description	Guanylyl cyclase GC-E precursor (EC 4.6.1.2) (Guanylate cyclase 2E).

GUC2D_HUMAN
NC score	0.588137 (rank : 24)	θ value	5.76516e-39 (rank : 13)
Query Neighborhood Hits	40	Target Neighborhood Hits	715	Shared Neighborhood Hits	31
SwissProt Accessions	Q02846, Q6LEA7	Gene names	GUCY2D, CORD6, GUC1A4, GUC2D, RETGC, RETGC1
Domain Architecture
Description	Retinal guanylyl cyclase 1 precursor (EC 4.6.1.2) (Guanylate cyclase 2D, retinal) (RETGC-1) (Rod outer segment membrane guanylate cyclase) (ROS-GC).

GUC2G_MOUSE
NC score	0.547358 (rank : 25)	θ value	1.6774e-38 (rank : 14)
Query Neighborhood Hits	40	Target Neighborhood Hits	644	Shared Neighborhood Hits	31
SwissProt Accessions	Q6TL19, Q8BWU7	Gene names	Gucy2g
Domain Architecture	No domain graphic available
Description	Guanylate cyclase 2G precursor (EC 4.6.1.2) (Guanylyl cyclase receptor G) (mGC-G).

ANPRB_MOUSE
NC score	0.545381 (rank : 26)	θ value	2.50074e-42 (rank : 9)
Query Neighborhood Hits	40	Target Neighborhood Hits	607	Shared Neighborhood Hits	31
SwissProt Accessions	Q6VVW5, Q6VVW3, Q6VVW4, Q8CGA9	Gene names	Npr2
Domain Architecture	No domain graphic available
Description	Atrial natriuretic peptide receptor B precursor (ANP-B) (ANPRB) (GC-B) (Guanylate cyclase B) (EC 4.6.1.2) (NPR-B) (Atrial natriuretic peptide B-type receptor).

ANPRA_MOUSE
NC score	0.535348 (rank : 27)	θ value	1.01529e-43 (rank : 7)
Query Neighborhood Hits	40	Target Neighborhood Hits	600	Shared Neighborhood Hits	31
SwissProt Accessions	P18293	Gene names	Npr1, Npra
Domain Architecture
Description	Atrial natriuretic peptide receptor A precursor (ANP-A) (ANPRA) (GC-A) (Guanylate cyclase) (EC 4.6.1.2) (NPR-A) (Atrial natriuretic peptide A-type receptor).

ANPRA_HUMAN
NC score	0.534259 (rank : 28)	θ value	3.26607e-42 (rank : 10)
Query Neighborhood Hits	40	Target Neighborhood Hits	612	Shared Neighborhood Hits	31
SwissProt Accessions	P16066, Q6P4Q3	Gene names	NPR1, ANPRA
Domain Architecture
Description	Atrial natriuretic peptide receptor A precursor (ANP-A) (ANPRA) (GC-A) (Guanylate cyclase) (EC 4.6.1.2) (NPR-A) (Atrial natriuretic peptide A-type receptor).

ANPRB_HUMAN
NC score	0.528695 (rank : 29)	θ value	1.91475e-42 (rank : 8)
Query Neighborhood Hits	40	Target Neighborhood Hits	646	Shared Neighborhood Hits	31
SwissProt Accessions	P20594, O60871, Q9UQ50	Gene names	NPR2, ANPRB
Domain Architecture
Description	Atrial natriuretic peptide receptor B precursor (ANP-B) (ANPRB) (GC-B) (Guanylate cyclase B) (EC 4.6.1.2) (NPR-B) (Atrial natriuretic peptide B-type receptor).

GUC2C_HUMAN
NC score	0.515250 (rank : 30)	θ value	1.73584e-35 (rank : 15)
Query Neighborhood Hits	40	Target Neighborhood Hits	624	Shared Neighborhood Hits	31
SwissProt Accessions	P25092	Gene names	GUCY2C, GUC2C, STAR
Domain Architecture
Description	Heat-stable enterotoxin receptor precursor (GC-C) (Intestinal guanylate cyclase) (EC 4.6.1.2) (STA receptor) (hSTAR).

GUC2F_HUMAN
NC score	0.498180 (rank : 31)	θ value	4.41421e-39 (rank : 12)
Query Neighborhood Hits	40	Target Neighborhood Hits	740	Shared Neighborhood Hits	31
SwissProt Accessions	P51841, Q9UJF1	Gene names	GUCY2F, GUC2F, RETGC2
Domain Architecture
Description	Retinal guanylyl cyclase 2 precursor (EC 4.6.1.2) (Guanylate cyclase 2F, retinal) (RETGC-2) (Rod outer segment membrane guanylate cyclase 2) (ROS-GC2) (Guanylate cyclase F) (GC-F).

ANPRC_HUMAN
NC score	0.264403 (rank : 32)	θ value	θ > 10 (rank : 41)
Query Neighborhood Hits	40	Target Neighborhood Hits	27	Shared Neighborhood Hits	8
SwissProt Accessions	P17342	Gene names	NPR3, ANPRC
Domain Architecture
Description	Atrial natriuretic peptide clearance receptor precursor (ANP-C) (ANPRC) (NPR-C) (Atrial natriuretic peptide C-type receptor).

ANPRC_MOUSE
NC score	0.258829 (rank : 33)	θ value	θ > 10 (rank : 42)
Query Neighborhood Hits	40	Target Neighborhood Hits	27	Shared Neighborhood Hits	8
SwissProt Accessions	P70180, P97804, Q9R025, Q9R027, Q9R028	Gene names	Npr3
Domain Architecture
Description	Atrial natriuretic peptide clearance receptor precursor (ANP-C) (ANPRC) (NPR-C) (Atrial natriuretic peptide C-type receptor) (EF-2).

GABR1_MOUSE
NC score	0.076442 (rank : 34)	θ value	θ > 10 (rank : 44)
Query Neighborhood Hits	40	Target Neighborhood Hits	139	Shared Neighborhood Hits	6
SwissProt Accessions	Q9WV18, Q9WU48, Q9WV15, Q9WV16, Q9WV17	Gene names	Gabbr1
Domain Architecture
Description	Gamma-aminobutyric acid type B receptor, subunit 1 precursor (GABA-B receptor 1) (GABA-B-R1) (Gb1).

GABR1_HUMAN
NC score	0.074179 (rank : 35)	θ value	θ > 10 (rank : 43)
Query Neighborhood Hits	40	Target Neighborhood Hits	142	Shared Neighborhood Hits	6
SwissProt Accessions	Q9UBS5, O95375, O95468, O95975, O96022, Q86W60, Q9UQQ0	Gene names	GABBR1, GPRC3A
Domain Architecture
Description	Gamma-aminobutyric acid type B receptor, subunit 1 precursor (GABA-B receptor 1) (GABA-B-R1) (Gb1).

IRAK3_HUMAN
NC score	0.071207 (rank : 36)	θ value	θ > 10 (rank : 47)
Query Neighborhood Hits	40	Target Neighborhood Hits	644	Shared Neighborhood Hits	9
SwissProt Accessions	Q9Y616	Gene names	IRAK3
Domain Architecture	No domain graphic available
Description	Interleukin-1 receptor-associated kinase 3 (EC 2.7.11.1) (IRAK-3) (IL- 1 receptor-associated kinase M) (IRAK-M).

RIPK2_HUMAN
NC score	0.070913 (rank : 37)	θ value	θ > 10 (rank : 58)
Query Neighborhood Hits	40	Target Neighborhood Hits	774	Shared Neighborhood Hits	9
SwissProt Accessions	O43353, Q6UWF0	Gene names	RIPK2, CARDIAK, RICK, RIP2
Domain Architecture
Description	Receptor-interacting serine/threonine-protein kinase 2 (EC 2.7.11.1) (RIP-like-interacting CLARP kinase) (Receptor-interacting protein 2) (RIP-2) (CARD-containing interleukin-1 beta-converting enzyme- associated kinase) (CARD-containing IL-1 beta ICE-kinase).

RIPK2_MOUSE
NC score	0.069365 (rank : 38)	θ value	θ > 10 (rank : 59)
Query Neighborhood Hits	40	Target Neighborhood Hits	776	Shared Neighborhood Hits	9
SwissProt Accessions	P58801	Gene names	Ripk2
Domain Architecture
Description	Receptor-interacting serine/threonine-protein kinase 2 (EC 2.7.11.1).

KSR1_HUMAN
NC score	0.069351 (rank : 39)	θ value	θ > 10 (rank : 49)
Query Neighborhood Hits	40	Target Neighborhood Hits	867	Shared Neighborhood Hits	9
SwissProt Accessions	Q8IVT5, Q13476	Gene names	KSR1, KSR
Domain Architecture	No domain graphic available
Description	Kinase suppressor of ras-1 (Kinase suppressor of ras).

IRAK3_MOUSE
NC score	0.069038 (rank : 40)	θ value	θ > 10 (rank : 48)
Query Neighborhood Hits	40	Target Neighborhood Hits	628	Shared Neighborhood Hits	9
SwissProt Accessions	Q8K4B2, Q8C7U8, Q8CE40, Q8K1S8	Gene names	Irak3
Domain Architecture	No domain graphic available
Description	Interleukin-1 receptor-associated kinase 3 (EC 2.7.11.1) (IRAK-3) (IL- 1 receptor-associated kinase M) (IRAK-M).

MLKL_HUMAN
NC score	0.068809 (rank : 41)	θ value	θ > 10 (rank : 52)
Query Neighborhood Hits	40	Target Neighborhood Hits	600	Shared Neighborhood Hits	9
SwissProt Accessions	Q8NB16, Q8N6V0	Gene names	MLKL
Domain Architecture	No domain graphic available
Description	Mixed lineage kinase domain-like protein.

KSR1_MOUSE
NC score	0.068414 (rank : 42)	θ value	θ > 10 (rank : 50)
Query Neighborhood Hits	40	Target Neighborhood Hits	870	Shared Neighborhood Hits	9
SwissProt Accessions	Q61097, Q61648, Q78DX8	Gene names	Ksr1, Ksr
Domain Architecture	No domain graphic available
Description	Kinase suppressor of ras-1 (Kinase suppressor of ras) (mKSR1) (Hb protein).

MLKL_MOUSE
NC score	0.067892 (rank : 43)	θ value	θ > 10 (rank : 53)
Query Neighborhood Hits	40	Target Neighborhood Hits	707	Shared Neighborhood Hits	9
SwissProt Accessions	Q9D2Y4, Q8CIJ5	Gene names	Mlkl
Domain Architecture	No domain graphic available
Description	Mixed lineage kinase domain-like protein.

KSR2_HUMAN
NC score	0.062185 (rank : 44)	θ value	θ > 10 (rank : 51)
Query Neighborhood Hits	40	Target Neighborhood Hits	920	Shared Neighborhood Hits	9
SwissProt Accessions	Q6VAB6, Q8N775	Gene names	KSR2
Domain Architecture	No domain graphic available
Description	Kinase suppressor of ras-2 (hKSR2).

RIPK1_MOUSE
NC score	0.061420 (rank : 45)	θ value	θ > 10 (rank : 57)
Query Neighborhood Hits	40	Target Neighborhood Hits	874	Shared Neighborhood Hits	9
SwissProt Accessions	Q60855, Q3U0J3, Q8CD90	Gene names	Ripk1, Rinp, Rip
Domain Architecture
Description	Receptor-interacting serine/threonine-protein kinase 1 (EC 2.7.11.1) (Serine/threonine-protein kinase RIP) (Cell death protein RIP) (Receptor-interacting protein).

RIPK1_HUMAN
NC score	0.059325 (rank : 46)	θ value	θ > 10 (rank : 56)
Query Neighborhood Hits	40	Target Neighborhood Hits	891	Shared Neighborhood Hits	9
SwissProt Accessions	Q13546, Q13180	Gene names	RIPK1, RIP
Domain Architecture
Description	Receptor-interacting serine/threonine-protein kinase 1 (EC 2.7.11.1) (Serine/threonine-protein kinase RIP) (Cell death protein RIP) (Receptor-interacting protein).

ILK_MOUSE
NC score	0.058762 (rank : 47)	θ value	θ > 10 (rank : 46)
Query Neighborhood Hits	40	Target Neighborhood Hits	858	Shared Neighborhood Hits	9
SwissProt Accessions	O55222	Gene names	Ilk
Domain Architecture
Description	Integrin-linked protein kinase (EC 2.7.11.1).

ILK1_HUMAN
NC score	0.058478 (rank : 48)	θ value	θ > 10 (rank : 45)
Query Neighborhood Hits	40	Target Neighborhood Hits	857	Shared Neighborhood Hits	9
SwissProt Accessions	Q13418	Gene names	ILK, ILK1
Domain Architecture
Description	Integrin-linked protein kinase 1 (EC 2.7.11.1) (ILK-1) (59 kDa serine/threonine-protein kinase) (p59ILK).

TOPK_HUMAN
NC score	0.055452 (rank : 49)	θ value	θ > 10 (rank : 62)
Query Neighborhood Hits	40	Target Neighborhood Hits	605	Shared Neighborhood Hits	9
SwissProt Accessions	Q96KB5, Q9NPD9, Q9NYL7, Q9NZK6	Gene names	PBK, TOPK
Domain Architecture	No domain graphic available
Description	T-lymphokine-activated killer cell-originated protein kinase (EC 2.7.12.2) (T-LAK cell-originated protein kinase) (PDZ-binding kinase) (Spermatogenesis-related protein kinase) (SPK) (MAPKK-like protein kinase) (Nori-3).

TOPK_MOUSE
NC score	0.052902 (rank : 50)	θ value	θ > 10 (rank : 63)
Query Neighborhood Hits	40	Target Neighborhood Hits	618	Shared Neighborhood Hits	9
SwissProt Accessions	Q9JJ78, Q922V2, Q9D184	Gene names	Pbk, Topk
Domain Architecture	No domain graphic available
Description	T-lymphokine-activated killer cell-originated protein kinase (EC 2.7.12.2) (T-LAK cell-originated protein kinase) (PDZ-binding kinase).

RIPK3_MOUSE
NC score	0.052608 (rank : 51)	θ value	θ > 10 (rank : 61)
Query Neighborhood Hits	40	Target Neighborhood Hits	867	Shared Neighborhood Hits	9
SwissProt Accessions	Q9QZL0	Gene names	Ripk3, Rip3
Domain Architecture
Description	Receptor-interacting serine/threonine-protein kinase 3 (EC 2.7.11.1) (RIP-like protein kinase 3) (Receptor-interacting protein 3) (RIP-3) (mRIP3).

RIPK3_HUMAN
NC score	0.051333 (rank : 52)	θ value	θ > 10 (rank : 60)
Query Neighborhood Hits	40	Target Neighborhood Hits	828	Shared Neighborhood Hits	9
SwissProt Accessions	Q9Y572	Gene names	RIPK3, RIP3
Domain Architecture
Description	Receptor-interacting serine/threonine-protein kinase 3 (EC 2.7.11.1) (RIP-like protein kinase 3) (Receptor-interacting protein 3) (RIP-3).

MLTK_MOUSE
NC score	0.051202 (rank : 53)	θ value	θ > 10 (rank : 55)
Query Neighborhood Hits	40	Target Neighborhood Hits	874	Shared Neighborhood Hits	9
SwissProt Accessions	Q9ESL4, Q3V1X8, Q8BR73, Q9ESL3	Gene names	Mltk
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase MLT (EC 2.7.11.25) (MLK-like mitogen-activated protein triple kinase) (Leucine zipper- and sterile alpha motif kinase ZAK) (Sterile alpha motif- and leucine zipper-containing kinase AZK) (Mixed lineage kinase-related kinase) (MLK-related kinase) (MRK).

MLTK_HUMAN
NC score	0.050890 (rank : 54)	θ value	θ > 10 (rank : 54)
Query Neighborhood Hits	40	Target Neighborhood Hits	911	Shared Neighborhood Hits	9
SwissProt Accessions	Q9NYL2, Q53SX1, Q580W8, Q59GY5, Q86YW8, Q9HCC4, Q9HCC5, Q9HDD2, Q9NYE9	Gene names	MLTK, ZAK
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase MLT (EC 2.7.11.25) (MLK-like mitogen-activated protein triple kinase) (Leucine zipper- and sterile alpha motif-containing kinase) (Sterile alpha motif- and leucine zipper-containing kinase AZK) (Mixed lineage kinase-related kinase) (MLK-related kinase) (MRK) (Cervical cancer suppressor gene 4 protein).

CCD24_HUMAN
NC score	0.040000 (rank : 55)	θ value	2.36792 (rank : 34)
Query Neighborhood Hits	40	Target Neighborhood Hits	23	Shared Neighborhood Hits	3
SwissProt Accessions	Q8N4L8, Q6RWT2	Gene names	CCDC24
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 24.

CF152_HUMAN
NC score	0.014409 (rank : 56)	θ value	1.06291 (rank : 33)
Query Neighborhood Hits	40	Target Neighborhood Hits	704	Shared Neighborhood Hits	4
SwissProt Accessions	Q86VQ0, Q9BWX7	Gene names	C6orf152
Domain Architecture	No domain graphic available
Description	Protein C6orf152.

FRAS1_MOUSE
NC score	0.010793 (rank : 57)	θ value	0.47712 (rank : 32)
Query Neighborhood Hits	40	Target Neighborhood Hits	747	Shared Neighborhood Hits	3
SwissProt Accessions	Q80T14, Q80TC7, Q811H8, Q8BPZ4	Gene names	Fras1, Kiaa1500
Domain Architecture	No domain graphic available
Description	Extracellular matrix protein FRAS1 precursor.

NOL8_HUMAN
NC score	0.009759 (rank : 58)	θ value	6.88961 (rank : 38)
Query Neighborhood Hits	40	Target Neighborhood Hits	297	Shared Neighborhood Hits	3
SwissProt Accessions	Q76FK4, Q5TCC7, Q5TCC8, Q5TCD3, Q5TCD5, Q5TCD6, Q5TCD7, Q76D35, Q7L3E2, Q9H586, Q9H795, Q9H7W7, Q9H9J6, Q9NWA4, Q9NWM4	Gene names	NOL8, NOP132
Domain Architecture	No domain graphic available
Description	Nucleolar protein 8 (Nucleolar protein Nop132).

MCF2_HUMAN
NC score	0.007948 (rank : 59)	θ value	6.88961 (rank : 37)
Query Neighborhood Hits	40	Target Neighborhood Hits	166	Shared Neighborhood Hits	3
SwissProt Accessions	P10911, P14919, Q5JYJ4, Q8IUF3, Q8IUF4, Q9UJB3	Gene names	MCF2, DBL
Domain Architecture
Description	Proto-oncogene DBL (Proto-oncogene MCF-2) [Contains: MCF2-transforming protein; DBL-transforming protein].

IFIH1_MOUSE
NC score	0.006148 (rank : 60)	θ value	8.99809 (rank : 39)
Query Neighborhood Hits	40	Target Neighborhood Hits	126	Shared Neighborhood Hits	3
SwissProt Accessions	Q8R5F7, Q3U6S2, Q68EM4, Q8BYC9, Q8BZ01, Q8K5C7, Q8R144, Q8VE79, Q99KS4, Q9D2Z5	Gene names	Ifih1
Domain Architecture	No domain graphic available
Description	Interferon-induced helicase C domain-containing protein 1 (EC 3.6.1.-) (Interferon induced with helicase C domain protein 1) (Helicase with 2 CARD domains) (Helicard) (Melanoma differentiation-associated protein 5) (MDA-5).

CARD9_HUMAN
NC score	0.005404 (rank : 61)	θ value	4.03905 (rank : 35)
Query Neighborhood Hits	40	Target Neighborhood Hits	602	Shared Neighborhood Hits	4
SwissProt Accessions	Q9H257, Q5SXM6, Q9H854	Gene names	CARD9
Domain Architecture
Description	Caspase recruitment domain-containing protein 9 (hCARD9).

GP120_HUMAN
NC score	0.003313 (rank : 62)	θ value	4.03905 (rank : 36)
Query Neighborhood Hits	40	Target Neighborhood Hits	458	Shared Neighborhood Hits	3
SwissProt Accessions	Q5NUL3, Q5VY25, Q5VY26, Q7Z605, Q86SM7	Gene names	GPR120, GPR129, PGR4
Domain Architecture	No domain graphic available
Description	G-protein coupled receptor 120 (G-protein coupled receptor PGR4) (G- protein coupled receptor GT01) (G-protein coupled receptor 129).

TLR10_HUMAN
NC score	0.002644 (rank : 63)	θ value	8.99809 (rank : 40)
Query Neighborhood Hits	40	Target Neighborhood Hits	295	Shared Neighborhood Hits	3
SwissProt Accessions	Q9BXR5, Q5FWG4, Q6UXL3	Gene names	TLR10
Domain Architecture
Description	Toll-like receptor 10 precursor.