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Network neighborhood for query Sequence : ADCY3_HUMAN

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ADCY3_HUMAN
SwissProt Accessions	O60266, Q9UDB1	Gene names	ADCY3, KIAA0511
Domain Architecture
Description	Adenylate cyclase type 3 (EC 4.6.1.1) (Adenylate cyclase type III) (Adenylate cyclase, olfactive type) (ATP pyrophosphate-lyase 3) (Adenylyl cyclase 3) (AC-III) (AC3).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

ADCY3_HUMAN
θ value	0 (rank : 1)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	58	Target Neighborhood Hits	58	Shared Neighborhood Hits	58
SwissProt Accessions	O60266, Q9UDB1	Gene names	ADCY3, KIAA0511
Domain Architecture
Description	Adenylate cyclase type 3 (EC 4.6.1.1) (Adenylate cyclase type III) (Adenylate cyclase, olfactive type) (ATP pyrophosphate-lyase 3) (Adenylyl cyclase 3) (AC-III) (AC3).

ADCY3_MOUSE
θ value	0 (rank : 2)	NC score	0.995171 (rank : 2)
Query Neighborhood Hits	58	Target Neighborhood Hits	47	Shared Neighborhood Hits	38
SwissProt Accessions	Q8VHH7	Gene names	Adcy3
Domain Architecture
Description	Adenylate cyclase type 3 (EC 4.6.1.1) (Adenylate cyclase type III) (Adenylate cyclase, olfactive type) (ATP pyrophosphate-lyase 3) (Adenylyl cyclase 3) (AC-III) (AC3).

ADCY8_HUMAN
θ value	0 (rank : 3)	NC score	0.979728 (rank : 3)
Query Neighborhood Hits	58	Target Neighborhood Hits	41	Shared Neighborhood Hits	31
SwissProt Accessions	P40145	Gene names	ADCY8
Domain Architecture
Description	Adenylate cyclase type 8 (EC 4.6.1.1) (Adenylate cyclase type VIII) (ATP pyrophosphate-lyase 8) (Ca(2+)/calmodulin-activated adenylyl cyclase).

ADCY8_MOUSE
θ value	0 (rank : 4)	NC score	0.979628 (rank : 4)
Query Neighborhood Hits	58	Target Neighborhood Hits	42	Shared Neighborhood Hits	31
SwissProt Accessions	P97490	Gene names	Adcy8
Domain Architecture
Description	Adenylate cyclase type 8 (EC 4.6.1.1) (Adenylate cyclase type VIII) (ATP pyrophosphate-lyase 8) (Ca(2+)/calmodulin-activated adenylyl cyclase).

ADCY6_HUMAN
θ value	2.25536e-168 (rank : 5)	NC score	0.977983 (rank : 5)
Query Neighborhood Hits	58	Target Neighborhood Hits	52	Shared Neighborhood Hits	31
SwissProt Accessions	O43306, Q9NR75	Gene names	ADCY6, KIAA0422
Domain Architecture
Description	Adenylate cyclase type 6 (EC 4.6.1.1) (Adenylate cyclase type VI) (ATP pyrophosphate-lyase 6) (Ca(2+)-inhibitable adenylyl cyclase).

ADCY6_MOUSE
θ value	2.25536e-168 (rank : 6)	NC score	0.977346 (rank : 6)
Query Neighborhood Hits	58	Target Neighborhood Hits	57	Shared Neighborhood Hits	31
SwissProt Accessions	Q01341	Gene names	Adcy6
Domain Architecture
Description	Adenylate cyclase type 6 (EC 4.6.1.1) (Adenylate cyclase type VI) (ATP pyrophosphate-lyase 6) (Ca(2+)-inhibitable adenylyl cyclase).

ADCY2_MOUSE
θ value	4.55495e-161 (rank : 7)	NC score	0.974533 (rank : 7)
Query Neighborhood Hits	58	Target Neighborhood Hits	38	Shared Neighborhood Hits	31
SwissProt Accessions	Q80TL1, Q8CFU6	Gene names	Adcy2, Kiaa1060
Domain Architecture	No domain graphic available
Description	Adenylate cyclase type 2 (EC 4.6.1.1) (Adenylate cyclase type II) (ATP pyrophosphate-lyase 2) (Adenylyl cyclase 2).

ADCY2_HUMAN
θ value	1.68038e-147 (rank : 8)	NC score	0.968018 (rank : 10)
Query Neighborhood Hits	58	Target Neighborhood Hits	38	Shared Neighborhood Hits	31
SwissProt Accessions	Q08462, Q9UPU2	Gene names	ADCY2, KIAA1060
Domain Architecture
Description	Adenylate cyclase type 2 (EC 4.6.1.1) (Adenylate cyclase type II) (ATP pyrophosphate-lyase 2) (Adenylyl cyclase 2).

ADCY7_MOUSE
θ value	3.06949e-141 (rank : 9)	NC score	0.973711 (rank : 9)
Query Neighborhood Hits	58	Target Neighborhood Hits	37	Shared Neighborhood Hits	31
SwissProt Accessions	P51829	Gene names	Adcy7
Domain Architecture
Description	Adenylate cyclase type 7 (EC 4.6.1.1) (Adenylate cyclase type VII) (ATP pyrophosphate-lyase 7) (Adenylyl cyclase 7).

ADCY7_HUMAN
θ value	1.52337e-140 (rank : 10)	NC score	0.974282 (rank : 8)
Query Neighborhood Hits	58	Target Neighborhood Hits	44	Shared Neighborhood Hits	31
SwissProt Accessions	P51828	Gene names	ADCY7, KIAA0037
Domain Architecture	No domain graphic available
Description	Adenylate cyclase type 7 (EC 4.6.1.1) (Adenylate cyclase type VII) (ATP pyrophosphate-lyase 7) (Adenylyl cyclase 7).

ADCY4_MOUSE
θ value	1.02182e-136 (rank : 11)	NC score	0.967085 (rank : 11)
Query Neighborhood Hits	58	Target Neighborhood Hits	40	Shared Neighborhood Hits	31
SwissProt Accessions	Q91WF3	Gene names	Adcy4
Domain Architecture
Description	Adenylate cyclase type 4 (EC 4.6.1.1) (Adenylate cyclase type IV) (ATP pyrophosphate-lyase 4) (Adenylyl cyclase 4).

ADCY4_HUMAN
θ value	8.9516e-133 (rank : 12)	NC score	0.966242 (rank : 12)
Query Neighborhood Hits	58	Target Neighborhood Hits	41	Shared Neighborhood Hits	31
SwissProt Accessions	Q8NFM4, Q96ML7	Gene names	ADCY4
Domain Architecture
Description	Adenylate cyclase type 4 (EC 4.6.1.1) (Adenylate cyclase type IV) (ATP pyrophosphate-lyase 4) (Adenylyl cyclase 4).

ADCY1_HUMAN
θ value	8.79181e-80 (rank : 13)	NC score	0.956498 (rank : 14)
Query Neighborhood Hits	58	Target Neighborhood Hits	42	Shared Neighborhood Hits	31
SwissProt Accessions	Q08828, Q75MI1	Gene names	ADCY1
Domain Architecture	No domain graphic available
Description	Adenylate cyclase type 1 (EC 4.6.1.1) (Adenylate cyclase type I) (ATP pyrophosphate-lyase 1) (Ca(2+)/calmodulin-activated adenylyl cyclase).

ADCY1_MOUSE
θ value	1.14825e-79 (rank : 14)	NC score	0.963602 (rank : 13)
Query Neighborhood Hits	58	Target Neighborhood Hits	40	Shared Neighborhood Hits	31
SwissProt Accessions	O88444, Q5SS89	Gene names	Adcy1
Domain Architecture	No domain graphic available
Description	Adenylate cyclase type 1 (EC 4.6.1.1) (Adenylate cyclase type I) (ATP pyrophosphate-lyase 1) (Ca(2+)/calmodulin-activated adenylyl cyclase).

ADCY9_MOUSE
θ value	1.51013e-55 (rank : 15)	NC score	0.907819 (rank : 16)
Query Neighborhood Hits	58	Target Neighborhood Hits	46	Shared Neighborhood Hits	31
SwissProt Accessions	P51830, Q61279	Gene names	Adcy9
Domain Architecture
Description	Adenylate cyclase type 9 (EC 4.6.1.1) (Adenylate cyclase type IX) (ATP pyrophosphate-lyase 9) (Adenylyl cyclase 9) (Adenylyl cyclase type 10) (ACTP10).

ADCY9_HUMAN
θ value	1.97229e-55 (rank : 16)	NC score	0.907891 (rank : 15)
Query Neighborhood Hits	58	Target Neighborhood Hits	51	Shared Neighborhood Hits	31
SwissProt Accessions	O60503, O60273, Q4ZHT9, Q4ZIR5, Q9BWT4, Q9UGP2	Gene names	ADCY9, KIAA0520
Domain Architecture
Description	Adenylate cyclase type 9 (EC 4.6.1.1) (Adenylate cyclase type IX) (ATP pyrophosphate-lyase 9) (Adenylyl cyclase 9).

ANPRB_HUMAN
θ value	8.63488e-27 (rank : 17)	NC score	0.447701 (rank : 29)
Query Neighborhood Hits	58	Target Neighborhood Hits	646	Shared Neighborhood Hits	33
SwissProt Accessions	P20594, O60871, Q9UQ50	Gene names	NPR2, ANPRB
Domain Architecture
Description	Atrial natriuretic peptide receptor B precursor (ANP-B) (ANPRB) (GC-B) (Guanylate cyclase B) (EC 4.6.1.2) (NPR-B) (Atrial natriuretic peptide B-type receptor).

ANPRA_MOUSE
θ value	1.12775e-26 (rank : 18)	NC score	0.452511 (rank : 27)
Query Neighborhood Hits	58	Target Neighborhood Hits	600	Shared Neighborhood Hits	33
SwissProt Accessions	P18293	Gene names	Npr1, Npra
Domain Architecture
Description	Atrial natriuretic peptide receptor A precursor (ANP-A) (ANPRA) (GC-A) (Guanylate cyclase) (EC 4.6.1.2) (NPR-A) (Atrial natriuretic peptide A-type receptor).

ANPRA_HUMAN
θ value	1.47289e-26 (rank : 19)	NC score	0.451334 (rank : 28)
Query Neighborhood Hits	58	Target Neighborhood Hits	612	Shared Neighborhood Hits	33
SwissProt Accessions	P16066, Q6P4Q3	Gene names	NPR1, ANPRA
Domain Architecture
Description	Atrial natriuretic peptide receptor A precursor (ANP-A) (ANPRA) (GC-A) (Guanylate cyclase) (EC 4.6.1.2) (NPR-A) (Atrial natriuretic peptide A-type receptor).

ANPRB_MOUSE
θ value	2.51237e-26 (rank : 20)	NC score	0.460433 (rank : 26)
Query Neighborhood Hits	58	Target Neighborhood Hits	607	Shared Neighborhood Hits	33
SwissProt Accessions	Q6VVW5, Q6VVW3, Q6VVW4, Q8CGA9	Gene names	Npr2
Domain Architecture	No domain graphic available
Description	Atrial natriuretic peptide receptor B precursor (ANP-B) (ANPRB) (GC-B) (Guanylate cyclase B) (EC 4.6.1.2) (NPR-B) (Atrial natriuretic peptide B-type receptor).

GCYA3_HUMAN
θ value	4.28545e-26 (rank : 21)	NC score	0.795078 (rank : 18)
Query Neighborhood Hits	58	Target Neighborhood Hits	36	Shared Neighborhood Hits	31
SwissProt Accessions	Q02108, O43843, Q8TAH3	Gene names	GUCY1A3, GUC1A3, GUCSA3, GUCY1A1
Domain Architecture
Description	Guanylate cyclase soluble subunit alpha-3 (EC 4.6.1.2) (GCS-alpha-3) (Soluble guanylate cyclase large subunit) (GCS-alpha-1).

GCYA3_MOUSE
θ value	1.24688e-25 (rank : 22)	NC score	0.793173 (rank : 20)
Query Neighborhood Hits	58	Target Neighborhood Hits	41	Shared Neighborhood Hits	31
SwissProt Accessions	Q9ERL9, Q9DBQ3	Gene names	Gucy1a3, Gucy1a1
Domain Architecture
Description	Guanylate cyclase soluble subunit alpha-3 (EC 4.6.1.2) (GCS-alpha-3) (Soluble guanylate cyclase large subunit) (GCS-alpha-1).

GUC2G_MOUSE
θ value	3.07116e-24 (rank : 23)	NC score	0.467258 (rank : 25)
Query Neighborhood Hits	58	Target Neighborhood Hits	644	Shared Neighborhood Hits	33
SwissProt Accessions	Q6TL19, Q8BWU7	Gene names	Gucy2g
Domain Architecture	No domain graphic available
Description	Guanylate cyclase 2G precursor (EC 4.6.1.2) (Guanylyl cyclase receptor G) (mGC-G).

GCYB2_HUMAN
θ value	4.01107e-24 (rank : 24)	NC score	0.814987 (rank : 17)
Query Neighborhood Hits	58	Target Neighborhood Hits	61	Shared Neighborhood Hits	31
SwissProt Accessions	O75343, Q9NZ64	Gene names	GUCY1B2
Domain Architecture
Description	Guanylate cyclase soluble subunit beta-2 (EC 4.6.1.2) (GCS-beta-2).

GCYA2_HUMAN
θ value	1.16704e-23 (rank : 25)	NC score	0.794950 (rank : 19)
Query Neighborhood Hits	58	Target Neighborhood Hits	50	Shared Neighborhood Hits	31
SwissProt Accessions	P33402	Gene names	GUCY1A2, GUC1A2, GUCSA2
Domain Architecture
Description	Guanylate cyclase soluble subunit alpha-2 (EC 4.6.1.2) (GCS-alpha-2).

GCYB1_HUMAN
θ value	6.40375e-22 (rank : 26)	NC score	0.784211 (rank : 22)
Query Neighborhood Hits	58	Target Neighborhood Hits	41	Shared Neighborhood Hits	31
SwissProt Accessions	Q02153, Q86WY5	Gene names	GUCY1B3, GUC1B3, GUCSB3, GUCY1B1
Domain Architecture
Description	Guanylate cyclase soluble subunit beta-1 (EC 4.6.1.2) (GCS-beta-1) (Soluble guanylate cyclase small subunit) (GCS-beta-3).

GUC2E_MOUSE
θ value	8.36355e-22 (rank : 27)	NC score	0.496878 (rank : 23)
Query Neighborhood Hits	58	Target Neighborhood Hits	692	Shared Neighborhood Hits	33
SwissProt Accessions	P52785	Gene names	Gucy2e, Guc2e
Domain Architecture
Description	Guanylyl cyclase GC-E precursor (EC 4.6.1.2) (Guanylate cyclase 2E).

GCYB1_MOUSE
θ value	1.09232e-21 (rank : 28)	NC score	0.784381 (rank : 21)
Query Neighborhood Hits	58	Target Neighborhood Hits	40	Shared Neighborhood Hits	31
SwissProt Accessions	O54865	Gene names	Gucy1b3
Domain Architecture	No domain graphic available
Description	Guanylate cyclase soluble subunit beta-1 (EC 4.6.1.2) (GCS-beta-1) (Soluble guanylate cyclase small subunit).

GUC2F_HUMAN
θ value	1.2077e-20 (rank : 29)	NC score	0.420535 (rank : 31)
Query Neighborhood Hits	58	Target Neighborhood Hits	740	Shared Neighborhood Hits	33
SwissProt Accessions	P51841, Q9UJF1	Gene names	GUCY2F, GUC2F, RETGC2
Domain Architecture
Description	Retinal guanylyl cyclase 2 precursor (EC 4.6.1.2) (Guanylate cyclase 2F, retinal) (RETGC-2) (Rod outer segment membrane guanylate cyclase 2) (ROS-GC2) (Guanylate cyclase F) (GC-F).

GUC2C_HUMAN
θ value	3.51386e-20 (rank : 30)	NC score	0.435917 (rank : 30)
Query Neighborhood Hits	58	Target Neighborhood Hits	624	Shared Neighborhood Hits	33
SwissProt Accessions	P25092	Gene names	GUCY2C, GUC2C, STAR
Domain Architecture
Description	Heat-stable enterotoxin receptor precursor (GC-C) (Intestinal guanylate cyclase) (EC 4.6.1.2) (STA receptor) (hSTAR).

GUC2D_HUMAN
θ value	7.82807e-20 (rank : 31)	NC score	0.493432 (rank : 24)
Query Neighborhood Hits	58	Target Neighborhood Hits	715	Shared Neighborhood Hits	33
SwissProt Accessions	Q02846, Q6LEA7	Gene names	GUCY2D, CORD6, GUC1A4, GUC2D, RETGC, RETGC1
Domain Architecture
Description	Retinal guanylyl cyclase 1 precursor (EC 4.6.1.2) (Guanylate cyclase 2D, retinal) (RETGC-1) (Rod outer segment membrane guanylate cyclase) (ROS-GC).

NUAK2_MOUSE
θ value	0.163984 (rank : 32)	NC score	0.012872 (rank : 39)
Query Neighborhood Hits	58	Target Neighborhood Hits	878	Shared Neighborhood Hits	13
SwissProt Accessions	Q8BZN4, Q80ZW3, Q8CIC0, Q9DBV0	Gene names	Nuak2
Domain Architecture	No domain graphic available
Description	NUAK family SNF1-like kinase 2 (EC 2.7.11.1).

JHD2B_HUMAN
θ value	0.62314 (rank : 33)	NC score	0.016923 (rank : 36)
Query Neighborhood Hits	58	Target Neighborhood Hits	171	Shared Neighborhood Hits	3
SwissProt Accessions	Q7LBC6, Q9BVH6, Q9BW93, Q9BZ52, Q9NYF4, Q9UPS0	Gene names	JMJD1B, C5orf7, JHDM2B, KIAA1082
Domain Architecture	No domain graphic available
Description	JmjC domain-containing histone demethylation protein 2B (EC 1.14.11.-) (Jumonji domain-containing protein 1B) (Nuclear protein 5qNCA).

JHD2B_MOUSE
θ value	0.813845 (rank : 34)	NC score	0.016832 (rank : 37)
Query Neighborhood Hits	58	Target Neighborhood Hits	115	Shared Neighborhood Hits	4
SwissProt Accessions	Q6ZPY7, Q2VPQ5, Q5U5V7, Q6P9K3, Q8CCE2, Q8K2A5, Q9CU57	Gene names	Jmjd1b, Jhdm2b, Kiaa1082
Domain Architecture	No domain graphic available
Description	JmjC domain-containing histone demethylation protein 2B (EC 1.14.11.-) (Jumonji domain-containing protein 1B).

SETD2_HUMAN
θ value	0.813845 (rank : 35)	NC score	0.015762 (rank : 38)
Query Neighborhood Hits	58	Target Neighborhood Hits	412	Shared Neighborhood Hits	4
SwissProt Accessions	Q9BYW2, O75397, O75405, Q17RW8, Q5BKS9, Q5QGN2, Q69YI5, Q6IN64, Q6ZN53, Q6ZS25, Q8N3R0, Q8TCN0, Q9C0D1, Q9H696, Q9NZW9	Gene names	SETD2, HIF1, HYPB, KIAA1732, SET2
Domain Architecture	No domain graphic available
Description	Histone-lysine N-methyltransferase, H3 lysine-36-specific (EC 2.1.1.43) (SET domain-containing protein 2) (hSET2) (Huntingtin- interacting protein HYPB) (Huntingtin-interacting protein 1) (HIF-1) (p231HBP).

UBE4B_MOUSE
θ value	0.813845 (rank : 36)	NC score	0.034602 (rank : 34)
Query Neighborhood Hits	58	Target Neighborhood Hits	42	Shared Neighborhood Hits	4
SwissProt Accessions	Q9ES00, Q9EQE0	Gene names	Ube4b, Ufd2
Domain Architecture
Description	Ubiquitin conjugation factor E4 B (Ubiquitin fusion degradation protein 2) (Ufd2a).

ASPN_MOUSE
θ value	1.06291 (rank : 37)	NC score	0.005960 (rank : 48)
Query Neighborhood Hits	58	Target Neighborhood Hits	277	Shared Neighborhood Hits	3
SwissProt Accessions	Q99MQ4, Q9D6A2	Gene names	Aspn
Domain Architecture
Description	Asporin precursor.

GNAS1_MOUSE
θ value	1.06291 (rank : 38)	NC score	0.004041 (rank : 50)
Query Neighborhood Hits	58	Target Neighborhood Hits	651	Shared Neighborhood Hits	5
SwissProt Accessions	Q6R0H7, Q6R0H4, Q6R0H5, Q6R2J5, Q9JJX0, Q9Z1N8	Gene names	Gnas, Gnas1
Domain Architecture	No domain graphic available
Description	Guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas (Adenylate cyclase-stimulating G alpha protein) (Extra large alphas protein) (XLalphas).

UBE4B_HUMAN
θ value	1.06291 (rank : 39)	NC score	0.031968 (rank : 35)
Query Neighborhood Hits	58	Target Neighborhood Hits	158	Shared Neighborhood Hits	4
SwissProt Accessions	O95155, O75169, O95338, Q5SZ12, Q5SZ16, Q96QD4, Q9BYI7	Gene names	UBE4B, HDNB1, KIAA0684, UFD2
Domain Architecture
Description	Ubiquitin conjugation factor E4 B (Ubiquitin fusion degradation protein 2) (Homozygously deleted in neuroblastoma 1).

DCX_HUMAN
θ value	1.38821 (rank : 40)	NC score	0.009400 (rank : 43)
Query Neighborhood Hits	58	Target Neighborhood Hits	141	Shared Neighborhood Hits	3
SwissProt Accessions	O43602, O43911	Gene names	DCX, DBCN, LISX
Domain Architecture
Description	Neuronal migration protein doublecortin (Lissencephalin-X) (Lis-X) (Doublin).

MBB1A_HUMAN
θ value	2.36792 (rank : 41)	NC score	0.007651 (rank : 45)
Query Neighborhood Hits	58	Target Neighborhood Hits	665	Shared Neighborhood Hits	4
SwissProt Accessions	Q9BQG0, Q86VM3, Q9BW49, Q9P0V5, Q9UF99	Gene names	MYBBP1A, P160
Domain Architecture	No domain graphic available
Description	Myb-binding protein 1A.

MTFR1_MOUSE
θ value	4.03905 (rank : 42)	NC score	0.010947 (rank : 41)
Query Neighborhood Hits	58	Target Neighborhood Hits	38	Shared Neighborhood Hits	2
SwissProt Accessions	Q99MB2, Q9CQZ4	Gene names	Mtfr1, Kiaa0009
Domain Architecture	No domain graphic available
Description	Mitochondrial fission regulator 1.

PCNT_MOUSE
θ value	4.03905 (rank : 43)	NC score	0.000111 (rank : 57)
Query Neighborhood Hits	58	Target Neighborhood Hits	1207	Shared Neighborhood Hits	4
SwissProt Accessions	P48725	Gene names	Pcnt, Pcnt2
Domain Architecture	No domain graphic available
Description	Pericentrin.

PRLPM_MOUSE
θ value	4.03905 (rank : 44)	NC score	0.010568 (rank : 42)
Query Neighborhood Hits	58	Target Neighborhood Hits	34	Shared Neighborhood Hits	3
SwissProt Accessions	Q9JHK0, Q9JI05	Gene names	Prlpm
Domain Architecture	No domain graphic available
Description	Placental prolactin-like protein M precursor (PRL-like protein M) (PLP-M).

SI1L3_HUMAN
θ value	4.03905 (rank : 45)	NC score	0.004765 (rank : 49)
Query Neighborhood Hits	58	Target Neighborhood Hits	305	Shared Neighborhood Hits	3
SwissProt Accessions	O60292, Q2TV87	Gene names	SIPA1L3, KIAA0545, SPAL3
Domain Architecture	No domain graphic available
Description	Signal-induced proliferation-associated 1-like protein 3 (SPA-1-like protein 3).

ADA12_HUMAN
θ value	5.27518 (rank : 46)	NC score	0.002391 (rank : 52)
Query Neighborhood Hits	58	Target Neighborhood Hits	224	Shared Neighborhood Hits	3
SwissProt Accessions	O43184, O60470	Gene names	ADAM12, MLTN
Domain Architecture
Description	ADAM 12 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase domain 12) (Meltrin alpha).

NAC1_MOUSE
θ value	5.27518 (rank : 47)	NC score	0.007387 (rank : 46)
Query Neighborhood Hits	58	Target Neighborhood Hits	41	Shared Neighborhood Hits	3
SwissProt Accessions	P70414	Gene names	Slc8a1, Ncx
Domain Architecture
Description	Sodium/calcium exchanger 1 precursor (Na(+)/Ca(2+)-exchange protein 1).

NEK11_HUMAN
θ value	5.27518 (rank : 48)	NC score	0.012837 (rank : 40)
Query Neighborhood Hits	58	Target Neighborhood Hits	1043	Shared Neighborhood Hits	12
SwissProt Accessions	Q8NG66, Q5JPC0, Q8NG65, Q8TBY1, Q9H5F4	Gene names	NEK11
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase Nek11 (EC 2.7.11.1) (NimA-related protein kinase 11) (Never in mitosis A-related kinase 11).

STEA1_MOUSE
θ value	5.27518 (rank : 49)	NC score	0.008172 (rank : 44)
Query Neighborhood Hits	58	Target Neighborhood Hits	5	Shared Neighborhood Hits	2
SwissProt Accessions	Q9CWR7, Q6P8X4	Gene names	Steap1, Steap
Domain Architecture	No domain graphic available
Description	Six transmembrane epithelial antigen of prostate 1.

NCOR2_HUMAN
θ value	6.88961 (rank : 50)	NC score	0.002084 (rank : 55)
Query Neighborhood Hits	58	Target Neighborhood Hits	870	Shared Neighborhood Hits	6
SwissProt Accessions	Q9Y618, O00613, O15416, Q13354, Q9Y5U0	Gene names	NCOR2, CTG26
Domain Architecture
Description	Nuclear receptor corepressor 2 (N-CoR2) (Silencing mediator of retinoic acid and thyroid hormone receptor) (SMRT) (SMRTe) (Thyroid-, retinoic-acid-receptor-associated corepressor) (T3 receptor- associating factor) (TRAC) (CTG repeat protein 26) (SMAP270).

ANR10_HUMAN
θ value	8.99809 (rank : 51)	NC score	-0.000207 (rank : 58)
Query Neighborhood Hits	58	Target Neighborhood Hits	289	Shared Neighborhood Hits	2
SwissProt Accessions	Q9NXR5	Gene names	ANKRD10
Domain Architecture
Description	Ankyrin repeat domain-containing protein 10.

BPTF_HUMAN
θ value	8.99809 (rank : 52)	NC score	0.000170 (rank : 56)
Query Neighborhood Hits	58	Target Neighborhood Hits	786	Shared Neighborhood Hits	4
SwissProt Accessions	Q12830, Q6NX67, Q7Z7D6, Q9UIG2	Gene names	FALZ, BPTF, FAC1
Domain Architecture
Description	Nucleosome remodeling factor subunit BPTF (Bromodomain and PHD finger- containing transcription factor) (Fetal Alzheimer antigen) (Fetal Alz- 50 clone 1 protein).

IRK4_HUMAN
θ value	8.99809 (rank : 53)	NC score	0.002145 (rank : 54)
Query Neighborhood Hits	58	Target Neighborhood Hits	39	Shared Neighborhood Hits	3
SwissProt Accessions	P48050	Gene names	KCNJ4
Domain Architecture
Description	Inward rectifier potassium channel 4 (Potassium channel, inwardly rectifying subfamily J member 4) (Inward rectifier K(+) channel Kir2.3) (Hippocampal inward rectifier) (HIR) (HRK1) (HIRK2).

IRK4_MOUSE
θ value	8.99809 (rank : 54)	NC score	0.002147 (rank : 53)
Query Neighborhood Hits	58	Target Neighborhood Hits	38	Shared Neighborhood Hits	3
SwissProt Accessions	P52189	Gene names	Kcnj4, Irk3
Domain Architecture
Description	Inward rectifier potassium channel 4 (Potassium channel, inwardly rectifying subfamily J member 4) (Inward rectifier K(+) channel Kir2.3) (IRK3).

NAC1_HUMAN
θ value	8.99809 (rank : 55)	NC score	0.006362 (rank : 47)
Query Neighborhood Hits	58	Target Neighborhood Hits	43	Shared Neighborhood Hits	3
SwissProt Accessions	P32418, O95849, Q9UBL8, Q9UDN1, Q9UDN2, Q9UKX6	Gene names	SLC8A1, CNC, NCX1
Domain Architecture
Description	Sodium/calcium exchanger 1 precursor (Na(+)/Ca(2+)-exchange protein 1).

PCNT_HUMAN
θ value	8.99809 (rank : 56)	NC score	-0.001769 (rank : 60)
Query Neighborhood Hits	58	Target Neighborhood Hits	1551	Shared Neighborhood Hits	7
SwissProt Accessions	O95613, O43152, Q7Z7C9	Gene names	PCNT, KIAA0402, PCNT2
Domain Architecture
Description	Pericentrin (Pericentrin B) (Kendrin).

TARA_HUMAN
θ value	8.99809 (rank : 57)	NC score	-0.001678 (rank : 59)
Query Neighborhood Hits	58	Target Neighborhood Hits	1626	Shared Neighborhood Hits	11
SwissProt Accessions	Q9H2D6, O94797, Q2PZW8, Q2Q3Z9, Q2Q400, Q5R3M6, Q96DW1, Q9BT77, Q9BTL7, Q9BY98, Q9Y3L4	Gene names	TRIOBP, KIAA1662, TARA
Domain Architecture
Description	TRIO and F-actin-binding protein (Protein Tara) (Trio-associated repeat on actin).

ZF106_MOUSE
θ value	8.99809 (rank : 58)	NC score	0.003155 (rank : 51)
Query Neighborhood Hits	58	Target Neighborhood Hits	472	Shared Neighborhood Hits	3
SwissProt Accessions	O88466, O55185, O88465, O88467, Q792M1, Q792P4, Q8CDZ8, Q8R3I4, Q9ESU3	Gene names	Zfp106, H3a, Sh3bp3, Sirm, Znf474
Domain Architecture	No domain graphic available
Description	Zinc finger protein 106 (Zfp-106) (Zinc finger protein 474) (H3a minor histocompatibility antigen) (Son of insulin receptor mutant).

ANPRC_HUMAN
θ value	θ > 10 (rank : 59)	NC score	0.163886 (rank : 32)
Query Neighborhood Hits	58	Target Neighborhood Hits	27	Shared Neighborhood Hits	8
SwissProt Accessions	P17342	Gene names	NPR3, ANPRC
Domain Architecture
Description	Atrial natriuretic peptide clearance receptor precursor (ANP-C) (ANPRC) (NPR-C) (Atrial natriuretic peptide C-type receptor).

ANPRC_MOUSE
θ value	θ > 10 (rank : 60)	NC score	0.160455 (rank : 33)
Query Neighborhood Hits	58	Target Neighborhood Hits	27	Shared Neighborhood Hits	8
SwissProt Accessions	P70180, P97804, Q9R025, Q9R027, Q9R028	Gene names	Npr3
Domain Architecture
Description	Atrial natriuretic peptide clearance receptor precursor (ANP-C) (ANPRC) (NPR-C) (Atrial natriuretic peptide C-type receptor) (EF-2).

Hits sorted by NC score

ADCY3_HUMAN
NC score	0.999962 (rank : 1)	θ value	0 (rank : 1)
Query Neighborhood Hits	58	Target Neighborhood Hits	58	Shared Neighborhood Hits	58
SwissProt Accessions	O60266, Q9UDB1	Gene names	ADCY3, KIAA0511
Domain Architecture
Description	Adenylate cyclase type 3 (EC 4.6.1.1) (Adenylate cyclase type III) (Adenylate cyclase, olfactive type) (ATP pyrophosphate-lyase 3) (Adenylyl cyclase 3) (AC-III) (AC3).

ADCY3_MOUSE
NC score	0.995171 (rank : 2)	θ value	0 (rank : 2)
Query Neighborhood Hits	58	Target Neighborhood Hits	47	Shared Neighborhood Hits	38
SwissProt Accessions	Q8VHH7	Gene names	Adcy3
Domain Architecture
Description	Adenylate cyclase type 3 (EC 4.6.1.1) (Adenylate cyclase type III) (Adenylate cyclase, olfactive type) (ATP pyrophosphate-lyase 3) (Adenylyl cyclase 3) (AC-III) (AC3).

ADCY8_HUMAN
NC score	0.979728 (rank : 3)	θ value	0 (rank : 3)
Query Neighborhood Hits	58	Target Neighborhood Hits	41	Shared Neighborhood Hits	31
SwissProt Accessions	P40145	Gene names	ADCY8
Domain Architecture
Description	Adenylate cyclase type 8 (EC 4.6.1.1) (Adenylate cyclase type VIII) (ATP pyrophosphate-lyase 8) (Ca(2+)/calmodulin-activated adenylyl cyclase).

ADCY8_MOUSE
NC score	0.979628 (rank : 4)	θ value	0 (rank : 4)
Query Neighborhood Hits	58	Target Neighborhood Hits	42	Shared Neighborhood Hits	31
SwissProt Accessions	P97490	Gene names	Adcy8
Domain Architecture
Description	Adenylate cyclase type 8 (EC 4.6.1.1) (Adenylate cyclase type VIII) (ATP pyrophosphate-lyase 8) (Ca(2+)/calmodulin-activated adenylyl cyclase).

ADCY6_HUMAN
NC score	0.977983 (rank : 5)	θ value	2.25536e-168 (rank : 5)
Query Neighborhood Hits	58	Target Neighborhood Hits	52	Shared Neighborhood Hits	31
SwissProt Accessions	O43306, Q9NR75	Gene names	ADCY6, KIAA0422
Domain Architecture
Description	Adenylate cyclase type 6 (EC 4.6.1.1) (Adenylate cyclase type VI) (ATP pyrophosphate-lyase 6) (Ca(2+)-inhibitable adenylyl cyclase).

ADCY6_MOUSE
NC score	0.977346 (rank : 6)	θ value	2.25536e-168 (rank : 6)
Query Neighborhood Hits	58	Target Neighborhood Hits	57	Shared Neighborhood Hits	31
SwissProt Accessions	Q01341	Gene names	Adcy6
Domain Architecture
Description	Adenylate cyclase type 6 (EC 4.6.1.1) (Adenylate cyclase type VI) (ATP pyrophosphate-lyase 6) (Ca(2+)-inhibitable adenylyl cyclase).

ADCY2_MOUSE
NC score	0.974533 (rank : 7)	θ value	4.55495e-161 (rank : 7)
Query Neighborhood Hits	58	Target Neighborhood Hits	38	Shared Neighborhood Hits	31
SwissProt Accessions	Q80TL1, Q8CFU6	Gene names	Adcy2, Kiaa1060
Domain Architecture	No domain graphic available
Description	Adenylate cyclase type 2 (EC 4.6.1.1) (Adenylate cyclase type II) (ATP pyrophosphate-lyase 2) (Adenylyl cyclase 2).

ADCY7_HUMAN
NC score	0.974282 (rank : 8)	θ value	1.52337e-140 (rank : 10)
Query Neighborhood Hits	58	Target Neighborhood Hits	44	Shared Neighborhood Hits	31
SwissProt Accessions	P51828	Gene names	ADCY7, KIAA0037
Domain Architecture	No domain graphic available
Description	Adenylate cyclase type 7 (EC 4.6.1.1) (Adenylate cyclase type VII) (ATP pyrophosphate-lyase 7) (Adenylyl cyclase 7).

ADCY7_MOUSE
NC score	0.973711 (rank : 9)	θ value	3.06949e-141 (rank : 9)
Query Neighborhood Hits	58	Target Neighborhood Hits	37	Shared Neighborhood Hits	31
SwissProt Accessions	P51829	Gene names	Adcy7
Domain Architecture
Description	Adenylate cyclase type 7 (EC 4.6.1.1) (Adenylate cyclase type VII) (ATP pyrophosphate-lyase 7) (Adenylyl cyclase 7).

ADCY2_HUMAN
NC score	0.968018 (rank : 10)	θ value	1.68038e-147 (rank : 8)
Query Neighborhood Hits	58	Target Neighborhood Hits	38	Shared Neighborhood Hits	31
SwissProt Accessions	Q08462, Q9UPU2	Gene names	ADCY2, KIAA1060
Domain Architecture
Description	Adenylate cyclase type 2 (EC 4.6.1.1) (Adenylate cyclase type II) (ATP pyrophosphate-lyase 2) (Adenylyl cyclase 2).

ADCY4_MOUSE
NC score	0.967085 (rank : 11)	θ value	1.02182e-136 (rank : 11)
Query Neighborhood Hits	58	Target Neighborhood Hits	40	Shared Neighborhood Hits	31
SwissProt Accessions	Q91WF3	Gene names	Adcy4
Domain Architecture
Description	Adenylate cyclase type 4 (EC 4.6.1.1) (Adenylate cyclase type IV) (ATP pyrophosphate-lyase 4) (Adenylyl cyclase 4).

ADCY4_HUMAN
NC score	0.966242 (rank : 12)	θ value	8.9516e-133 (rank : 12)
Query Neighborhood Hits	58	Target Neighborhood Hits	41	Shared Neighborhood Hits	31
SwissProt Accessions	Q8NFM4, Q96ML7	Gene names	ADCY4
Domain Architecture
Description	Adenylate cyclase type 4 (EC 4.6.1.1) (Adenylate cyclase type IV) (ATP pyrophosphate-lyase 4) (Adenylyl cyclase 4).

ADCY1_MOUSE
NC score	0.963602 (rank : 13)	θ value	1.14825e-79 (rank : 14)
Query Neighborhood Hits	58	Target Neighborhood Hits	40	Shared Neighborhood Hits	31
SwissProt Accessions	O88444, Q5SS89	Gene names	Adcy1
Domain Architecture	No domain graphic available
Description	Adenylate cyclase type 1 (EC 4.6.1.1) (Adenylate cyclase type I) (ATP pyrophosphate-lyase 1) (Ca(2+)/calmodulin-activated adenylyl cyclase).

ADCY1_HUMAN
NC score	0.956498 (rank : 14)	θ value	8.79181e-80 (rank : 13)
Query Neighborhood Hits	58	Target Neighborhood Hits	42	Shared Neighborhood Hits	31
SwissProt Accessions	Q08828, Q75MI1	Gene names	ADCY1
Domain Architecture	No domain graphic available
Description	Adenylate cyclase type 1 (EC 4.6.1.1) (Adenylate cyclase type I) (ATP pyrophosphate-lyase 1) (Ca(2+)/calmodulin-activated adenylyl cyclase).

ADCY9_HUMAN
NC score	0.907891 (rank : 15)	θ value	1.97229e-55 (rank : 16)
Query Neighborhood Hits	58	Target Neighborhood Hits	51	Shared Neighborhood Hits	31
SwissProt Accessions	O60503, O60273, Q4ZHT9, Q4ZIR5, Q9BWT4, Q9UGP2	Gene names	ADCY9, KIAA0520
Domain Architecture
Description	Adenylate cyclase type 9 (EC 4.6.1.1) (Adenylate cyclase type IX) (ATP pyrophosphate-lyase 9) (Adenylyl cyclase 9).

ADCY9_MOUSE
NC score	0.907819 (rank : 16)	θ value	1.51013e-55 (rank : 15)
Query Neighborhood Hits	58	Target Neighborhood Hits	46	Shared Neighborhood Hits	31
SwissProt Accessions	P51830, Q61279	Gene names	Adcy9
Domain Architecture
Description	Adenylate cyclase type 9 (EC 4.6.1.1) (Adenylate cyclase type IX) (ATP pyrophosphate-lyase 9) (Adenylyl cyclase 9) (Adenylyl cyclase type 10) (ACTP10).

GCYB2_HUMAN
NC score	0.814987 (rank : 17)	θ value	4.01107e-24 (rank : 24)
Query Neighborhood Hits	58	Target Neighborhood Hits	61	Shared Neighborhood Hits	31
SwissProt Accessions	O75343, Q9NZ64	Gene names	GUCY1B2
Domain Architecture
Description	Guanylate cyclase soluble subunit beta-2 (EC 4.6.1.2) (GCS-beta-2).

GCYA3_HUMAN
NC score	0.795078 (rank : 18)	θ value	4.28545e-26 (rank : 21)
Query Neighborhood Hits	58	Target Neighborhood Hits	36	Shared Neighborhood Hits	31
SwissProt Accessions	Q02108, O43843, Q8TAH3	Gene names	GUCY1A3, GUC1A3, GUCSA3, GUCY1A1
Domain Architecture
Description	Guanylate cyclase soluble subunit alpha-3 (EC 4.6.1.2) (GCS-alpha-3) (Soluble guanylate cyclase large subunit) (GCS-alpha-1).

GCYA2_HUMAN
NC score	0.794950 (rank : 19)	θ value	1.16704e-23 (rank : 25)
Query Neighborhood Hits	58	Target Neighborhood Hits	50	Shared Neighborhood Hits	31
SwissProt Accessions	P33402	Gene names	GUCY1A2, GUC1A2, GUCSA2
Domain Architecture
Description	Guanylate cyclase soluble subunit alpha-2 (EC 4.6.1.2) (GCS-alpha-2).

GCYA3_MOUSE
NC score	0.793173 (rank : 20)	θ value	1.24688e-25 (rank : 22)
Query Neighborhood Hits	58	Target Neighborhood Hits	41	Shared Neighborhood Hits	31
SwissProt Accessions	Q9ERL9, Q9DBQ3	Gene names	Gucy1a3, Gucy1a1
Domain Architecture
Description	Guanylate cyclase soluble subunit alpha-3 (EC 4.6.1.2) (GCS-alpha-3) (Soluble guanylate cyclase large subunit) (GCS-alpha-1).

GCYB1_MOUSE
NC score	0.784381 (rank : 21)	θ value	1.09232e-21 (rank : 28)
Query Neighborhood Hits	58	Target Neighborhood Hits	40	Shared Neighborhood Hits	31
SwissProt Accessions	O54865	Gene names	Gucy1b3
Domain Architecture	No domain graphic available
Description	Guanylate cyclase soluble subunit beta-1 (EC 4.6.1.2) (GCS-beta-1) (Soluble guanylate cyclase small subunit).

GCYB1_HUMAN
NC score	0.784211 (rank : 22)	θ value	6.40375e-22 (rank : 26)
Query Neighborhood Hits	58	Target Neighborhood Hits	41	Shared Neighborhood Hits	31
SwissProt Accessions	Q02153, Q86WY5	Gene names	GUCY1B3, GUC1B3, GUCSB3, GUCY1B1
Domain Architecture
Description	Guanylate cyclase soluble subunit beta-1 (EC 4.6.1.2) (GCS-beta-1) (Soluble guanylate cyclase small subunit) (GCS-beta-3).

GUC2E_MOUSE
NC score	0.496878 (rank : 23)	θ value	8.36355e-22 (rank : 27)
Query Neighborhood Hits	58	Target Neighborhood Hits	692	Shared Neighborhood Hits	33
SwissProt Accessions	P52785	Gene names	Gucy2e, Guc2e
Domain Architecture
Description	Guanylyl cyclase GC-E precursor (EC 4.6.1.2) (Guanylate cyclase 2E).

GUC2D_HUMAN
NC score	0.493432 (rank : 24)	θ value	7.82807e-20 (rank : 31)
Query Neighborhood Hits	58	Target Neighborhood Hits	715	Shared Neighborhood Hits	33
SwissProt Accessions	Q02846, Q6LEA7	Gene names	GUCY2D, CORD6, GUC1A4, GUC2D, RETGC, RETGC1
Domain Architecture
Description	Retinal guanylyl cyclase 1 precursor (EC 4.6.1.2) (Guanylate cyclase 2D, retinal) (RETGC-1) (Rod outer segment membrane guanylate cyclase) (ROS-GC).

GUC2G_MOUSE
NC score	0.467258 (rank : 25)	θ value	3.07116e-24 (rank : 23)
Query Neighborhood Hits	58	Target Neighborhood Hits	644	Shared Neighborhood Hits	33
SwissProt Accessions	Q6TL19, Q8BWU7	Gene names	Gucy2g
Domain Architecture	No domain graphic available
Description	Guanylate cyclase 2G precursor (EC 4.6.1.2) (Guanylyl cyclase receptor G) (mGC-G).

ANPRB_MOUSE
NC score	0.460433 (rank : 26)	θ value	2.51237e-26 (rank : 20)
Query Neighborhood Hits	58	Target Neighborhood Hits	607	Shared Neighborhood Hits	33
SwissProt Accessions	Q6VVW5, Q6VVW3, Q6VVW4, Q8CGA9	Gene names	Npr2
Domain Architecture	No domain graphic available
Description	Atrial natriuretic peptide receptor B precursor (ANP-B) (ANPRB) (GC-B) (Guanylate cyclase B) (EC 4.6.1.2) (NPR-B) (Atrial natriuretic peptide B-type receptor).

ANPRA_MOUSE
NC score	0.452511 (rank : 27)	θ value	1.12775e-26 (rank : 18)
Query Neighborhood Hits	58	Target Neighborhood Hits	600	Shared Neighborhood Hits	33
SwissProt Accessions	P18293	Gene names	Npr1, Npra
Domain Architecture
Description	Atrial natriuretic peptide receptor A precursor (ANP-A) (ANPRA) (GC-A) (Guanylate cyclase) (EC 4.6.1.2) (NPR-A) (Atrial natriuretic peptide A-type receptor).

ANPRA_HUMAN
NC score	0.451334 (rank : 28)	θ value	1.47289e-26 (rank : 19)
Query Neighborhood Hits	58	Target Neighborhood Hits	612	Shared Neighborhood Hits	33
SwissProt Accessions	P16066, Q6P4Q3	Gene names	NPR1, ANPRA
Domain Architecture
Description	Atrial natriuretic peptide receptor A precursor (ANP-A) (ANPRA) (GC-A) (Guanylate cyclase) (EC 4.6.1.2) (NPR-A) (Atrial natriuretic peptide A-type receptor).

ANPRB_HUMAN
NC score	0.447701 (rank : 29)	θ value	8.63488e-27 (rank : 17)
Query Neighborhood Hits	58	Target Neighborhood Hits	646	Shared Neighborhood Hits	33
SwissProt Accessions	P20594, O60871, Q9UQ50	Gene names	NPR2, ANPRB
Domain Architecture
Description	Atrial natriuretic peptide receptor B precursor (ANP-B) (ANPRB) (GC-B) (Guanylate cyclase B) (EC 4.6.1.2) (NPR-B) (Atrial natriuretic peptide B-type receptor).

GUC2C_HUMAN
NC score	0.435917 (rank : 30)	θ value	3.51386e-20 (rank : 30)
Query Neighborhood Hits	58	Target Neighborhood Hits	624	Shared Neighborhood Hits	33
SwissProt Accessions	P25092	Gene names	GUCY2C, GUC2C, STAR
Domain Architecture
Description	Heat-stable enterotoxin receptor precursor (GC-C) (Intestinal guanylate cyclase) (EC 4.6.1.2) (STA receptor) (hSTAR).

GUC2F_HUMAN
NC score	0.420535 (rank : 31)	θ value	1.2077e-20 (rank : 29)
Query Neighborhood Hits	58	Target Neighborhood Hits	740	Shared Neighborhood Hits	33
SwissProt Accessions	P51841, Q9UJF1	Gene names	GUCY2F, GUC2F, RETGC2
Domain Architecture
Description	Retinal guanylyl cyclase 2 precursor (EC 4.6.1.2) (Guanylate cyclase 2F, retinal) (RETGC-2) (Rod outer segment membrane guanylate cyclase 2) (ROS-GC2) (Guanylate cyclase F) (GC-F).

ANPRC_HUMAN
NC score	0.163886 (rank : 32)	θ value	θ > 10 (rank : 59)
Query Neighborhood Hits	58	Target Neighborhood Hits	27	Shared Neighborhood Hits	8
SwissProt Accessions	P17342	Gene names	NPR3, ANPRC
Domain Architecture
Description	Atrial natriuretic peptide clearance receptor precursor (ANP-C) (ANPRC) (NPR-C) (Atrial natriuretic peptide C-type receptor).

ANPRC_MOUSE
NC score	0.160455 (rank : 33)	θ value	θ > 10 (rank : 60)
Query Neighborhood Hits	58	Target Neighborhood Hits	27	Shared Neighborhood Hits	8
SwissProt Accessions	P70180, P97804, Q9R025, Q9R027, Q9R028	Gene names	Npr3
Domain Architecture
Description	Atrial natriuretic peptide clearance receptor precursor (ANP-C) (ANPRC) (NPR-C) (Atrial natriuretic peptide C-type receptor) (EF-2).

UBE4B_MOUSE
NC score	0.034602 (rank : 34)	θ value	0.813845 (rank : 36)
Query Neighborhood Hits	58	Target Neighborhood Hits	42	Shared Neighborhood Hits	4
SwissProt Accessions	Q9ES00, Q9EQE0	Gene names	Ube4b, Ufd2
Domain Architecture
Description	Ubiquitin conjugation factor E4 B (Ubiquitin fusion degradation protein 2) (Ufd2a).

UBE4B_HUMAN
NC score	0.031968 (rank : 35)	θ value	1.06291 (rank : 39)
Query Neighborhood Hits	58	Target Neighborhood Hits	158	Shared Neighborhood Hits	4
SwissProt Accessions	O95155, O75169, O95338, Q5SZ12, Q5SZ16, Q96QD4, Q9BYI7	Gene names	UBE4B, HDNB1, KIAA0684, UFD2
Domain Architecture
Description	Ubiquitin conjugation factor E4 B (Ubiquitin fusion degradation protein 2) (Homozygously deleted in neuroblastoma 1).

JHD2B_HUMAN
NC score	0.016923 (rank : 36)	θ value	0.62314 (rank : 33)
Query Neighborhood Hits	58	Target Neighborhood Hits	171	Shared Neighborhood Hits	3
SwissProt Accessions	Q7LBC6, Q9BVH6, Q9BW93, Q9BZ52, Q9NYF4, Q9UPS0	Gene names	JMJD1B, C5orf7, JHDM2B, KIAA1082
Domain Architecture	No domain graphic available
Description	JmjC domain-containing histone demethylation protein 2B (EC 1.14.11.-) (Jumonji domain-containing protein 1B) (Nuclear protein 5qNCA).

JHD2B_MOUSE
NC score	0.016832 (rank : 37)	θ value	0.813845 (rank : 34)
Query Neighborhood Hits	58	Target Neighborhood Hits	115	Shared Neighborhood Hits	4
SwissProt Accessions	Q6ZPY7, Q2VPQ5, Q5U5V7, Q6P9K3, Q8CCE2, Q8K2A5, Q9CU57	Gene names	Jmjd1b, Jhdm2b, Kiaa1082
Domain Architecture	No domain graphic available
Description	JmjC domain-containing histone demethylation protein 2B (EC 1.14.11.-) (Jumonji domain-containing protein 1B).

SETD2_HUMAN
NC score	0.015762 (rank : 38)	θ value	0.813845 (rank : 35)
Query Neighborhood Hits	58	Target Neighborhood Hits	412	Shared Neighborhood Hits	4
SwissProt Accessions	Q9BYW2, O75397, O75405, Q17RW8, Q5BKS9, Q5QGN2, Q69YI5, Q6IN64, Q6ZN53, Q6ZS25, Q8N3R0, Q8TCN0, Q9C0D1, Q9H696, Q9NZW9	Gene names	SETD2, HIF1, HYPB, KIAA1732, SET2
Domain Architecture	No domain graphic available
Description	Histone-lysine N-methyltransferase, H3 lysine-36-specific (EC 2.1.1.43) (SET domain-containing protein 2) (hSET2) (Huntingtin- interacting protein HYPB) (Huntingtin-interacting protein 1) (HIF-1) (p231HBP).

NUAK2_MOUSE
NC score	0.012872 (rank : 39)	θ value	0.163984 (rank : 32)
Query Neighborhood Hits	58	Target Neighborhood Hits	878	Shared Neighborhood Hits	13
SwissProt Accessions	Q8BZN4, Q80ZW3, Q8CIC0, Q9DBV0	Gene names	Nuak2
Domain Architecture	No domain graphic available
Description	NUAK family SNF1-like kinase 2 (EC 2.7.11.1).

NEK11_HUMAN
NC score	0.012837 (rank : 40)	θ value	5.27518 (rank : 48)
Query Neighborhood Hits	58	Target Neighborhood Hits	1043	Shared Neighborhood Hits	12
SwissProt Accessions	Q8NG66, Q5JPC0, Q8NG65, Q8TBY1, Q9H5F4	Gene names	NEK11
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase Nek11 (EC 2.7.11.1) (NimA-related protein kinase 11) (Never in mitosis A-related kinase 11).

MTFR1_MOUSE
NC score	0.010947 (rank : 41)	θ value	4.03905 (rank : 42)
Query Neighborhood Hits	58	Target Neighborhood Hits	38	Shared Neighborhood Hits	2
SwissProt Accessions	Q99MB2, Q9CQZ4	Gene names	Mtfr1, Kiaa0009
Domain Architecture	No domain graphic available
Description	Mitochondrial fission regulator 1.

PRLPM_MOUSE
NC score	0.010568 (rank : 42)	θ value	4.03905 (rank : 44)
Query Neighborhood Hits	58	Target Neighborhood Hits	34	Shared Neighborhood Hits	3
SwissProt Accessions	Q9JHK0, Q9JI05	Gene names	Prlpm
Domain Architecture	No domain graphic available
Description	Placental prolactin-like protein M precursor (PRL-like protein M) (PLP-M).

DCX_HUMAN
NC score	0.009400 (rank : 43)	θ value	1.38821 (rank : 40)
Query Neighborhood Hits	58	Target Neighborhood Hits	141	Shared Neighborhood Hits	3
SwissProt Accessions	O43602, O43911	Gene names	DCX, DBCN, LISX
Domain Architecture
Description	Neuronal migration protein doublecortin (Lissencephalin-X) (Lis-X) (Doublin).

STEA1_MOUSE
NC score	0.008172 (rank : 44)	θ value	5.27518 (rank : 49)
Query Neighborhood Hits	58	Target Neighborhood Hits	5	Shared Neighborhood Hits	2
SwissProt Accessions	Q9CWR7, Q6P8X4	Gene names	Steap1, Steap
Domain Architecture	No domain graphic available
Description	Six transmembrane epithelial antigen of prostate 1.

MBB1A_HUMAN
NC score	0.007651 (rank : 45)	θ value	2.36792 (rank : 41)
Query Neighborhood Hits	58	Target Neighborhood Hits	665	Shared Neighborhood Hits	4
SwissProt Accessions	Q9BQG0, Q86VM3, Q9BW49, Q9P0V5, Q9UF99	Gene names	MYBBP1A, P160
Domain Architecture	No domain graphic available
Description	Myb-binding protein 1A.

NAC1_MOUSE
NC score	0.007387 (rank : 46)	θ value	5.27518 (rank : 47)
Query Neighborhood Hits	58	Target Neighborhood Hits	41	Shared Neighborhood Hits	3
SwissProt Accessions	P70414	Gene names	Slc8a1, Ncx
Domain Architecture
Description	Sodium/calcium exchanger 1 precursor (Na(+)/Ca(2+)-exchange protein 1).

NAC1_HUMAN
NC score	0.006362 (rank : 47)	θ value	8.99809 (rank : 55)
Query Neighborhood Hits	58	Target Neighborhood Hits	43	Shared Neighborhood Hits	3
SwissProt Accessions	P32418, O95849, Q9UBL8, Q9UDN1, Q9UDN2, Q9UKX6	Gene names	SLC8A1, CNC, NCX1
Domain Architecture
Description	Sodium/calcium exchanger 1 precursor (Na(+)/Ca(2+)-exchange protein 1).

ASPN_MOUSE
NC score	0.005960 (rank : 48)	θ value	1.06291 (rank : 37)
Query Neighborhood Hits	58	Target Neighborhood Hits	277	Shared Neighborhood Hits	3
SwissProt Accessions	Q99MQ4, Q9D6A2	Gene names	Aspn
Domain Architecture
Description	Asporin precursor.

SI1L3_HUMAN
NC score	0.004765 (rank : 49)	θ value	4.03905 (rank : 45)
Query Neighborhood Hits	58	Target Neighborhood Hits	305	Shared Neighborhood Hits	3
SwissProt Accessions	O60292, Q2TV87	Gene names	SIPA1L3, KIAA0545, SPAL3
Domain Architecture	No domain graphic available
Description	Signal-induced proliferation-associated 1-like protein 3 (SPA-1-like protein 3).

GNAS1_MOUSE
NC score	0.004041 (rank : 50)	θ value	1.06291 (rank : 38)
Query Neighborhood Hits	58	Target Neighborhood Hits	651	Shared Neighborhood Hits	5
SwissProt Accessions	Q6R0H7, Q6R0H4, Q6R0H5, Q6R2J5, Q9JJX0, Q9Z1N8	Gene names	Gnas, Gnas1
Domain Architecture	No domain graphic available
Description	Guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas (Adenylate cyclase-stimulating G alpha protein) (Extra large alphas protein) (XLalphas).

ZF106_MOUSE
NC score	0.003155 (rank : 51)	θ value	8.99809 (rank : 58)
Query Neighborhood Hits	58	Target Neighborhood Hits	472	Shared Neighborhood Hits	3
SwissProt Accessions	O88466, O55185, O88465, O88467, Q792M1, Q792P4, Q8CDZ8, Q8R3I4, Q9ESU3	Gene names	Zfp106, H3a, Sh3bp3, Sirm, Znf474
Domain Architecture	No domain graphic available
Description	Zinc finger protein 106 (Zfp-106) (Zinc finger protein 474) (H3a minor histocompatibility antigen) (Son of insulin receptor mutant).

ADA12_HUMAN
NC score	0.002391 (rank : 52)	θ value	5.27518 (rank : 46)
Query Neighborhood Hits	58	Target Neighborhood Hits	224	Shared Neighborhood Hits	3
SwissProt Accessions	O43184, O60470	Gene names	ADAM12, MLTN
Domain Architecture
Description	ADAM 12 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase domain 12) (Meltrin alpha).

IRK4_MOUSE
NC score	0.002147 (rank : 53)	θ value	8.99809 (rank : 54)
Query Neighborhood Hits	58	Target Neighborhood Hits	38	Shared Neighborhood Hits	3
SwissProt Accessions	P52189	Gene names	Kcnj4, Irk3
Domain Architecture
Description	Inward rectifier potassium channel 4 (Potassium channel, inwardly rectifying subfamily J member 4) (Inward rectifier K(+) channel Kir2.3) (IRK3).

IRK4_HUMAN
NC score	0.002145 (rank : 54)	θ value	8.99809 (rank : 53)
Query Neighborhood Hits	58	Target Neighborhood Hits	39	Shared Neighborhood Hits	3
SwissProt Accessions	P48050	Gene names	KCNJ4
Domain Architecture
Description	Inward rectifier potassium channel 4 (Potassium channel, inwardly rectifying subfamily J member 4) (Inward rectifier K(+) channel Kir2.3) (Hippocampal inward rectifier) (HIR) (HRK1) (HIRK2).

NCOR2_HUMAN
NC score	0.002084 (rank : 55)	θ value	6.88961 (rank : 50)
Query Neighborhood Hits	58	Target Neighborhood Hits	870	Shared Neighborhood Hits	6
SwissProt Accessions	Q9Y618, O00613, O15416, Q13354, Q9Y5U0	Gene names	NCOR2, CTG26
Domain Architecture
Description	Nuclear receptor corepressor 2 (N-CoR2) (Silencing mediator of retinoic acid and thyroid hormone receptor) (SMRT) (SMRTe) (Thyroid-, retinoic-acid-receptor-associated corepressor) (T3 receptor- associating factor) (TRAC) (CTG repeat protein 26) (SMAP270).

BPTF_HUMAN
NC score	0.000170 (rank : 56)	θ value	8.99809 (rank : 52)
Query Neighborhood Hits	58	Target Neighborhood Hits	786	Shared Neighborhood Hits	4
SwissProt Accessions	Q12830, Q6NX67, Q7Z7D6, Q9UIG2	Gene names	FALZ, BPTF, FAC1
Domain Architecture
Description	Nucleosome remodeling factor subunit BPTF (Bromodomain and PHD finger- containing transcription factor) (Fetal Alzheimer antigen) (Fetal Alz- 50 clone 1 protein).

PCNT_MOUSE
NC score	0.000111 (rank : 57)	θ value	4.03905 (rank : 43)
Query Neighborhood Hits	58	Target Neighborhood Hits	1207	Shared Neighborhood Hits	4
SwissProt Accessions	P48725	Gene names	Pcnt, Pcnt2
Domain Architecture	No domain graphic available
Description	Pericentrin.

ANR10_HUMAN
NC score	-0.000207 (rank : 58)	θ value	8.99809 (rank : 51)
Query Neighborhood Hits	58	Target Neighborhood Hits	289	Shared Neighborhood Hits	2
SwissProt Accessions	Q9NXR5	Gene names	ANKRD10
Domain Architecture
Description	Ankyrin repeat domain-containing protein 10.

TARA_HUMAN
NC score	-0.001678 (rank : 59)	θ value	8.99809 (rank : 57)
Query Neighborhood Hits	58	Target Neighborhood Hits	1626	Shared Neighborhood Hits	11
SwissProt Accessions	Q9H2D6, O94797, Q2PZW8, Q2Q3Z9, Q2Q400, Q5R3M6, Q96DW1, Q9BT77, Q9BTL7, Q9BY98, Q9Y3L4	Gene names	TRIOBP, KIAA1662, TARA
Domain Architecture
Description	TRIO and F-actin-binding protein (Protein Tara) (Trio-associated repeat on actin).

PCNT_HUMAN
NC score	-0.001769 (rank : 60)	θ value	8.99809 (rank : 56)
Query Neighborhood Hits	58	Target Neighborhood Hits	1551	Shared Neighborhood Hits	7
SwissProt Accessions	O95613, O43152, Q7Z7C9	Gene names	PCNT, KIAA0402, PCNT2
Domain Architecture
Description	Pericentrin (Pericentrin B) (Kendrin).